                               SEQUENCE LISTING

<110> SHIRE HUMAN GENETIC THERAPIES, INC.

<120> MESSENGER RNA THERAPY FOR TREATMENT OF ARTICULAR DISEASE

<130> 2006685-1291

<140>
<141>

<150> 62/088,141
<151> 2014-12-05

<160> 4     

<170> PatentIn version 3.5

<210> 1
<211> 1899
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> Variation
<222> (1794)..(1794)
<223> /replace=" "

<220>
<221> Variation
<222> (1896)..(1896)
<223> /replace=" "

<220>
<221> misc_feature
<222> (1)..(1899)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 1
ggacagaucg ccuggagacg ccauccacgc uguuuugacc uccauagaag acaccgggac       60

cgauccagcc uccgcggccg ggaacggugc auuggaacgc ggauuccccg ugccaagagu      120

gacucaccgu ccuugacacg auggaagaug ccaaaaacau uaagaagggc ccagcgccau      180

ucuacccacu cgaagacggg accgccggcg agcagcugca caaagccaug aagcgcuacg      240

cccuggugcc cggcaccauc gccuuuaccg acgcacauau cgagguggac auuaccuacg      300

ccgaguacuu cgagaugagc guucggcugg cagaagcuau gaagcgcuau gggcugaaua      360

caaaccaucg gaucguggug ugcagcgaga auagcuugca guucuucaug cccguguugg      420

gugcccuguu caucggugug gcuguggccc cagcuaacga caucuacaac gagcgcgagc      480

ugcugaacag caugggcauc agccagccca ccgucguauu cgugagcaag aaagggcugc      540

aaaagauccu caacgugcaa aagaagcuac cgaucauaca aaagaucauc aucauggaua      600

gcaagaccga cuaccagggc uuccaaagca uguacaccuu cgugacuucc cauuugccac      660

ccggcuucaa cgaguacgac uucgugcccg agagcuucga ccgggacaaa accaucgccc      720

ugaucaugaa caguaguggc aguaccggau ugcccaaggg cguagcccua ccgcaccgca      780

ccgcuugugu ccgauucagu caugcccgcg accccaucuu cggcaaccag aucauccccg      840

acaccgcuau ccucagcgug gugccauuuc accacggcuu cggcauguuc accacgcugg      900

gcuacuugau cugcggcuuu cgggucgugc ucauguaccg cuucgaggag gagcuauucu      960

ugcgcagcuu gcaagacuau aagauucaau cugcccugcu ggugcccaca cuauuuagcu     1020

ucuucgcuaa gagcacucuc aucgacaagu acgaccuaag caacuugcac gagaucgcca     1080

gcggcggggc gccgcucagc aaggagguag gugaggccgu ggccaaacgc uuccaccuac     1140

caggcauccg ccagggcuac ggccugacag aaacaaccag cgccauucug aucacccccg     1200

aaggggacga caagccuggc gcaguaggca agguggugcc cuucuucgag gcuaaggugg     1260

uggacuugga caccgguaag acacugggug ugaaccagcg cggcgagcug ugcguccgug     1320

gccccaugau caugagcggc uacguuaaca accccgaggc uacaaacgcu cucaucgaca     1380

aggacggcug gcugcacagc ggcgacaucg ccuacuggga cgaggacgag cacuucuuca     1440

ucguggaccg gcugaagagc cugaucaaau acaagggcua ccagguagcc ccagccgaac     1500

uggagagcau ccugcugcaa caccccaaca ucuucgacgc cggggucgcc ggccugcccg     1560

acgacgaugc cggcgagcug cccgccgcag ucgucgugcu ggaacacggu aaaaccauga     1620

ccgagaagga gaucguggac uauguggcca gccagguuac aaccgccaag aagcugcgcg     1680

gugguguugu guucguggac gaggugccua aaggacugac cggcaaguug gacgcccgca     1740

agauccgcga gauucucauu aaggccaaga agggcggcaa gaucgccgug uaacgggugg     1800

caucccugug accccucccc agugccucuc cuggcccugg aaguugccac uccagugccc     1860

accagccuug uccuaauaaa auuaaguugc aucaaagcu                            1899


<210> 2
<211> 140
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 2
ggacagaucg ccuggagacg ccauccacgc uguuuugacc uccauagaag acaccgggac       60

cgauccagcc uccgcggccg ggaacggugc auuggaacgc ggauuccccg ugccaagagu      120

gacucaccgu ccuugacacg                                                  140


<210> 3
<211> 105
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 3
cggguggcau cccugugacc ccuccccagu gccucuccug gcccuggaag uugccacucc       60

agugcccacc agccuugucc uaauaaaauu aaguugcauc aagcu                      105


<210> 4
<211> 105
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 4
ggguggcauc ccugugaccc cuccccagug ccucuccugg cccuggaagu ugccacucca       60

gugcccacca gccuuguccu aauaaaauua aguugcauca aagcu                      105


