                         SEQUENCE LISTING

<110>  Deisseroth, Karl A.
       Ramakrishnan, Charu
       Zalocusky, Kelly
 
<120>  DOPAMINE RECEPTOR TYPE 2 SPECIFIC PROMOTER AND METHODS OF USE 
       THEREOF

<130>  STAN-1158WO

<150>  US 62/087,603
<151>  2014-12-04

<160>  66    

<170>  PatentIn version 3.5

<210>  1
<211>  1552
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid

<400>  1
ttatcctcgg tgcatctcag agaaataagc attgcttgga ccaatgtgga ccggatgtta       60

acacctagag ccagagagat taaaaaattt aatcaacatc tacaactggc aagggataga      120

cataggacac acgactgggt ggaaaacgta tagaggtgat gggttgagaa gaacaaaatc      180

cctgtttaag taggttattt cttgggaaga acatgtccag ggcacatagg aaaatagtgg      240

ggattcaacc atgtctgtaa tgtgtgagtg ccttaaaagc aaatgtgaaa aattctaatg      300

tttctggtag ttctaacact tccctaccat gcctatagag agccatgaat agaccatacc      360

ccaagaataa tgaatagggg aaggggaggc tagttcccct tttcttaaat gcctccataa      420

ctggccacat ctaagaaaaa tgtgctgtgt atagggactg ttccactgct ggttccccgt      480

gaggtttgga ggggcatgcc tctttgggtc ccagattcca cctttgaaat caaacagggg      540

ttagttgaat attagtgtct gtctttccaa ccttaatttt ccaggattgt gtggatcaat      600

ggaaggagtt tcttctttgt ggctaagtgg catgactgcc ggctatatgc agactgtcct      660

ctgtgctcct gcccttggaa ttctgtggtg ccttctcctt ggggacttga attggccaat      720

ggccagctcc tgtgaggtct ccggagctgt cggtactcca cagcacctat ttaagctaca      780

agtatttgga agactctact ctggattgac cccatgcatt ctgaatctca tgtagaagct      840

ggccaaggca ggacagaggg acagaaagca ccagctggat ttgagaagaa gaggatggaa      900

agggttgtag gttccctggg tgggagatga ccctggacag ggctgaagaa gatcacattt      960

ctcttcctcc tgctcctcag tgcagacgga agggtgagct agaattttca cggccttctt     1020

tatcattccc atcttagatc tgctctgccc aagtcttcct ctcagaaagc acaacagcag     1080

aacgaactgc tgtgattttc agacctgagg tctgtacacc gactctggat atccttccgg     1140

aatctatttc tcctttaaag acttgatgta ccacacgtag tgcttcagct agcccttggc     1200

cctgactcct caaaggaggg gatcgacccg ctggtgttgt gattgctaga ccagagtagg     1260

tttggatggg cagggtgtta cttaaaaagt ataggatgac accggcgagc agtccggagc     1320

acaggctatc cccactcaaa gccagagatg gattctcggt ctcagctctc aaggttcctt     1380

ccccaggccc cacagtgcag agatagttct ggggccctgg gtgggtgggg cctctgtaca     1440

aggggcgggg ttcccgggcg cctcgtggcc agggtgaccc cgccccctcc tcctgcgcag     1500

cgctctgatt ccgcggagct gtccagcctc agtgccgggg ggatccgcca cc             1552


<210>  2
<211>  1810
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid

<400>  2
ttatcctcgg tgcatctcag agaaataagc attgcttgga ccaatgtgga ccggatgtta       60

acacctagag ccagagagat taaaaaattt aatcaacatc tacaactggc aagggataga      120

cataggacac acgactgggt ggaaaacgta tagaggtgat gggttgagaa gaacaaaatc      180

cctgtttaag taggttattt cttgggaaga acatgtccag ggcacatagg aaaatagtgg      240

ggattcaacc atgtctgtaa tgtgtgagtg ccttaaaagc aaatgtgaaa aattctaatg      300

tttctggtag ttctaacact tccctaccat gcctatagag agccatgaat agaccatacc      360

ccaagaataa tgaatagggg aaggggaggc tagttcccct tttcttaaat gcctccataa      420

ctggccacat ctaagaaaaa tgtgctgtgt atagggactg ttccactgct ggttccccgt      480

gaggtttgga ggggcatgcc tctttgggtc ccagattcca cctttgaaat caaacagggg      540

ttagttgaat attagtgtct gtctttccaa ccttaatttt ccaggattgt gtggatcaat      600

ggaaggagtt tcttctttgt ggctaagtgg catgactgcc ggctatatgc agactgtcct      660

ctgtgctcct gcccttggaa ttctgtggtg ccttctcctt ggggacttga attggccaat      720

ggccagctcc tgtgaggtct ccggagctgt cggtactcca cagcacctat ttaagctaca      780

agtatttgga agactctact ctggattgac cccatgcatt ctgaatctca tgtagaagct      840

ggccaaggca ggacagaggg acagaaagca ccagctggat ttgagaagaa gaggatggaa      900

agggttgtag gttccctggg tgggagatga ccctggacag ggctgaagaa gatcacattt      960

ctcttcctcc tgctcctcag tgcagacgga agggtgagct agaattttca cggccttctt     1020

tatcattccc atcttagatc tgctctgccc aagtcttcct ctcagaaagc acaacagcag     1080

aacgaactgc tgtgattttc agacctgagg tctgtacacc gactctggat atccttccgg     1140

aatctatttc tcctttaaag acttgatgta ccacacgtag tgcttcagct agcccttggc     1200

cctgactcct caaaggaggg gatcgacccg ctggtgttgt gattgctaga ccagagtagg     1260

tttggatggg cagggtgtta cttaaaaagt ataggatgac accggcgagc agtccggagc     1320

acaggctatc cccactcaaa gccagagatg gattctcggt ctcagctctc aaggttcctt     1380

ccccaggccc cacagtgcag agatagttct ggggccctgg gtgggtgggg cctctgtaca     1440

aggggcgggg ttcccgggcg cctcgtggcc agggtgaccc cgccccctcc tcctgcgcag     1500

cgctctgatt ccgcggagct gtccagcctc agtgccgggg ctggtcccct cttgtgcgcg     1560

gcgcctcctg gccggcttcc cgcctggttc ccgcgctggg ctcccgtcct cccgccccgc     1620

cttcgtcctg ccccgccgcg gccggtctac tgctccccgc gggcccgagc cggccgagcg     1680

gctgcccgcc ggggatctga acggcgcggc ggggccggaa gccgagggac ccgcggaggg     1740

gaccggcggc cccggacggc tgccggaggg gcggccgtgc gtggatgcgg cgggagctgg     1800

aagcctcgag                                                            1810


<210>  3
<211>  313
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid

<400>  3
ctggtcccct cttgtgcgcg gcgcctcctg gccggcttcc cgcctggttc ccgcgctggg       60

ctcccgtcct cccgccccgc cttcgtcctg ccccgccgcg gccggtctac tgctccccgc      120

gggcccgagc cggccgagcg gctgcccgcc ggggatctga acggcgcggc ggggccggaa      180

gccgagggac ccgcggaggg gaccggcggc cccggacggc tgccggaggg gcggccgtgc      240

gtggatgcgg cgggagctgg aagcctcgag cagccggcgc cttctctggc cccgggcgcc      300

atatggcttg aag                                                         313


<210>  4
<211>  310
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Arg Glu Leu Leu Phe 
1               5                   10                  15      


Val Thr Asn Pro Val Val Val Asn Gly Ser Val Leu Val Pro Glu Asp 
            20                  25                  30          


Gln Cys Tyr Cys Ala Gly Trp Ile Glu Ser Arg Gly Thr Asn Gly Ala 
        35                  40                  45              


Gln Thr Ala Ser Asn Val Leu Gln Trp Leu Ala Ala Gly Phe Ser Ile 
    50                  55                  60                  


Leu Leu Leu Met Phe Tyr Ala Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Cys Ala Ile Glu Met Val Lys Val Ile Leu 
                85                  90                  95      


Glu Phe Phe Phe Glu Phe Lys Asn Pro Ser Met Leu Tyr Leu Ala Thr 
            100                 105                 110         


Gly His Arg Val Gln Trp Leu Arg Tyr Ala Glu Trp Leu Leu Thr Cys 
        115                 120                 125             


Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr Gly Leu Ser Asn Asp 
    130                 135                 140                 


Tyr Ser Arg Arg Thr Met Gly Leu Leu Val Ser Asp Ile Gly Thr Ile 
145                 150                 155                 160 


Val Trp Gly Ala Thr Ser Ala Met Ala Thr Gly Tyr Val Lys Val Ile 
                165                 170                 175     


Phe Phe Cys Leu Gly Leu Cys Tyr Gly Ala Asn Thr Phe Phe His Ala 
            180                 185                 190         


Ala Lys Ala Tyr Ile Glu Gly Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Val Tyr Gly Ser Thr Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Asn Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val Pro 
305                 310 


<210>  5
<211>  340
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Arg Glu Leu Leu Phe 
1               5                   10                  15      


Val Thr Asn Pro Val Val Val Asn Gly Ser Val Leu Val Pro Glu Asp 
            20                  25                  30          


Gln Cys Tyr Cys Ala Gly Trp Ile Glu Ser Arg Gly Thr Asn Gly Ala 
        35                  40                  45              


Gln Thr Ala Ser Asn Val Leu Gln Trp Leu Ala Ala Gly Phe Ser Ile 
    50                  55                  60                  


Leu Leu Leu Met Phe Tyr Ala Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Cys Ala Ile Glu Met Val Lys Val Ile Leu 
                85                  90                  95      


Glu Phe Phe Phe Glu Phe Lys Asn Pro Ser Met Leu Tyr Leu Ala Thr 
            100                 105                 110         


Gly His Arg Val Gln Trp Leu Arg Tyr Ala Glu Trp Leu Leu Thr Cys 
        115                 120                 125             


Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr Gly Leu Ser Asn Asp 
    130                 135                 140                 


Tyr Ser Arg Arg Thr Met Gly Leu Leu Val Ser Asp Ile Gly Thr Ile 
145                 150                 155                 160 


Val Trp Gly Ala Thr Ser Ala Met Ala Thr Gly Tyr Val Lys Val Ile 
                165                 170                 175     


Phe Phe Cys Leu Gly Leu Cys Tyr Gly Ala Asn Thr Phe Phe His Ala 
            180                 185                 190         


Ala Lys Ala Tyr Ile Glu Gly Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Val Tyr Gly Ser Thr Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Asn Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val Pro Ala Ala Ala Lys Ser Arg Ile Thr Ser Glu 
305                 310                 315                 320 


Gly Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asn Val Phe Cys Tyr 
                325                 330                 335     


Glu Asn Glu Val 
            340 


<210>  6
<211>  310
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Arg Glu Leu Leu Phe 
1               5                   10                  15      


Val Thr Asn Pro Val Val Val Asn Gly Ser Val Leu Val Pro Glu Asp 
            20                  25                  30          


Gln Cys Tyr Cys Ala Gly Trp Ile Glu Ser Arg Gly Thr Asn Gly Ala 
        35                  40                  45              


Gln Thr Ala Ser Asn Val Leu Gln Trp Leu Ala Ala Gly Phe Ser Ile 
    50                  55                  60                  


Leu Leu Leu Met Phe Tyr Ala Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Cys Ala Ile Glu Met Val Lys Val Ile Leu 
                85                  90                  95      


Glu Phe Phe Phe Glu Phe Lys Asn Pro Ser Met Leu Tyr Leu Ala Thr 
            100                 105                 110         


Gly His Arg Val Gln Trp Leu Arg Tyr Ala Glu Trp Leu Leu Thr Ser 
        115                 120                 125             


Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr Gly Leu Ser Asn Asp 
    130                 135                 140                 


Tyr Ser Arg Arg Thr Met Gly Leu Leu Val Ser Ala Ile Gly Thr Ile 
145                 150                 155                 160 


Val Trp Gly Ala Thr Ser Ala Met Ala Thr Gly Tyr Val Lys Val Ile 
                165                 170                 175     


Phe Phe Cys Leu Gly Leu Cys Tyr Gly Ala Asn Thr Phe Phe His Ala 
            180                 185                 190         


Ala Lys Ala Tyr Ile Glu Gly Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Val Tyr Gly Ser Thr Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Asn Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val Pro 
305                 310 


<210>  7
<211>  340
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Arg Glu Leu Leu Phe 
1               5                   10                  15      


Val Thr Asn Pro Val Val Val Asn Gly Ser Val Leu Val Pro Glu Asp 
            20                  25                  30          


Gln Cys Tyr Cys Ala Gly Trp Ile Glu Ser Arg Gly Thr Asn Gly Ala 
        35                  40                  45              


Gln Thr Ala Ser Asn Val Leu Gln Trp Leu Ala Ala Gly Phe Ser Ile 
    50                  55                  60                  


Leu Leu Leu Met Phe Tyr Ala Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Cys Ala Ile Glu Met Val Lys Val Ile Leu 
                85                  90                  95      


Glu Phe Phe Phe Glu Phe Lys Asn Pro Ser Met Leu Tyr Leu Ala Thr 
            100                 105                 110         


Gly His Arg Val Gln Trp Leu Arg Tyr Ala Glu Trp Leu Leu Thr Ser 
        115                 120                 125             


Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr Gly Leu Ser Asn Asp 
    130                 135                 140                 


Tyr Ser Arg Arg Thr Met Gly Leu Leu Val Ser Ala Ile Gly Thr Ile 
145                 150                 155                 160 


Val Trp Gly Ala Thr Ser Ala Met Ala Thr Gly Tyr Val Lys Val Ile 
                165                 170                 175     


Phe Phe Cys Leu Gly Leu Cys Tyr Gly Ala Asn Thr Phe Phe His Ala 
            180                 185                 190         


Ala Lys Ala Tyr Ile Glu Gly Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Val Tyr Gly Ser Thr Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Asn Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val Pro Ala Ala Ala Lys Ser Arg Ile Thr Ser Glu 
305                 310                 315                 320 


Gly Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asn Val Phe Cys Tyr 
                325                 330                 335     


Glu Asn Glu Val 
            340 


<210>  8
<211>  300
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Met Asp Tyr Pro Val Ala Arg Ser Leu Ile Val Arg Tyr Pro Thr Asp 
1               5                   10                  15      


Leu Gly Asn Gly Thr Val Cys Met Pro Arg Gly Gln Cys Tyr Cys Glu 
            20                  25                  30          


Gly Trp Leu Arg Ser Arg Gly Thr Ser Ile Glu Lys Thr Ile Ala Ile 
        35                  40                  45              


Thr Leu Gln Trp Val Val Phe Ala Leu Ser Val Ala Cys Leu Gly Trp 
    50                  55                  60                  


Tyr Ala Tyr Gln Ala Trp Arg Ala Thr Cys Gly Trp Glu Glu Val Tyr 
65                  70                  75                  80  


Val Ala Leu Ile Glu Met Met Lys Ser Ile Ile Glu Ala Phe His Glu 
                85                  90                  95      


Phe Asp Ser Pro Ala Thr Leu Trp Leu Ser Ser Gly Asn Gly Val Val 
            100                 105                 110         


Trp Met Arg Tyr Gly Glu Trp Leu Leu Thr Cys Pro Val Leu Leu Ile 
        115                 120                 125             


His Leu Ser Asn Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg Thr 
    130                 135                 140                 


Met Gly Leu Leu Val Ser Asp Val Gly Cys Ile Val Trp Gly Ala Thr 
145                 150                 155                 160 


Ser Ala Met Cys Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile Ser 
                165                 170                 175     


Leu Ser Tyr Gly Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr Ile 
            180                 185                 190         


Glu Ala Phe His Thr Val Pro Lys Gly Ile Cys Arg Glu Leu Val Arg 
        195                 200                 205             


Val Met Ala Trp Thr Phe Phe Val Ala Trp Gly Met Phe Pro Val Leu 
    210                 215                 220                 


Phe Leu Leu Gly Thr Glu Gly Phe Gly His Ile Ser Pro Tyr Gly Ser 
225                 230                 235                 240 


Ala Ile Gly His Ser Ile Leu Asp Leu Ile Ala Lys Asn Met Trp Gly 
                245                 250                 255     


Val Leu Gly Asn Tyr Leu Arg Val Lys Ile His Glu His Ile Leu Leu 
            260                 265                 270         


Tyr Gly Asp Ile Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln Glu 
        275                 280                 285             


Met Glu Val Glu Thr Leu Val Ala Glu Glu Glu Asp 
    290                 295                 300 


<210>  9
<211>  330
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Met Asp Tyr Pro Val Ala Arg Ser Leu Ile Val Arg Tyr Pro Thr Asp 
1               5                   10                  15      


Leu Gly Asn Gly Thr Val Cys Met Pro Arg Gly Gln Cys Tyr Cys Glu 
            20                  25                  30          


Gly Trp Leu Arg Ser Arg Gly Thr Ser Ile Glu Lys Thr Ile Ala Ile 
        35                  40                  45              


Thr Leu Gln Trp Val Val Phe Ala Leu Ser Val Ala Cys Leu Gly Trp 
    50                  55                  60                  


Tyr Ala Tyr Gln Ala Trp Arg Ala Thr Cys Gly Trp Glu Glu Val Tyr 
65                  70                  75                  80  


Val Ala Leu Ile Glu Met Met Lys Ser Ile Ile Glu Ala Phe His Glu 
                85                  90                  95      


Phe Asp Ser Pro Ala Thr Leu Trp Leu Ser Ser Gly Asn Gly Val Val 
            100                 105                 110         


Trp Met Arg Tyr Gly Glu Trp Leu Leu Thr Cys Pro Val Leu Leu Ile 
        115                 120                 125             


His Leu Ser Asn Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg Thr 
    130                 135                 140                 


Met Gly Leu Leu Val Ser Asp Val Gly Cys Ile Val Trp Gly Ala Thr 
145                 150                 155                 160 


Ser Ala Met Cys Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile Ser 
                165                 170                 175     


Leu Ser Tyr Gly Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr Ile 
            180                 185                 190         


Glu Ala Phe His Thr Val Pro Lys Gly Ile Cys Arg Glu Leu Val Arg 
        195                 200                 205             


Val Met Ala Trp Thr Phe Phe Val Ala Trp Gly Met Phe Pro Val Leu 
    210                 215                 220                 


Phe Leu Leu Gly Thr Glu Gly Phe Gly His Ile Ser Pro Tyr Gly Ser 
225                 230                 235                 240 


Ala Ile Gly His Ser Ile Leu Asp Leu Ile Ala Lys Asn Met Trp Gly 
                245                 250                 255     


Val Leu Gly Asn Tyr Leu Arg Val Lys Ile His Glu His Ile Leu Leu 
            260                 265                 270         


Tyr Gly Asp Ile Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln Glu 
        275                 280                 285             


Met Glu Val Glu Thr Leu Val Ala Glu Glu Glu Asp Ala Ala Ala Lys 
    290                 295                 300                 


Ser Arg Ile Thr Ser Glu Gly Glu Tyr Ile Pro Leu Asp Gln Ile Asp 
305                 310                 315                 320 


Ile Asn Val Phe Cys Tyr Glu Asn Glu Val 
                325                 330 


<210>  10
<211>  344
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Met Ser Arg Arg Pro Trp Leu Leu Ala Leu Ala Leu Ala Val Ala Leu 
1               5                   10                  15      


Ala Ala Gly Ser Ala Gly Ala Ser Thr Gly Ser Asp Ala Thr Val Pro 
            20                  25                  30          


Val Ala Thr Gln Asp Gly Pro Asp Tyr Val Phe His Arg Ala His Glu 
        35                  40                  45              


Arg Met Leu Phe Gln Thr Ser Tyr Thr Leu Glu Asn Asn Gly Ser Val 
    50                  55                  60                  


Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys Leu Ala Trp Leu Lys 
65                  70                  75                  80  


Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala Asn Ile Leu Gln Trp 
                85                  90                  95      


Ile Thr Phe Ala Leu Ser Ala Leu Cys Leu Met Phe Tyr Gly Tyr Gln 
            100                 105                 110         


Thr Trp Lys Ser Thr Cys Gly Trp Glu Glu Ile Tyr Val Ala Thr Ile 
        115                 120                 125             


Glu Met Ile Lys Phe Ile Ile Glu Tyr Phe His Glu Phe Asp Glu Pro 
    130                 135                 140                 


Ala Val Ile Tyr Ser Ser Asn Gly Asn Lys Thr Val Trp Leu Arg Tyr 
145                 150                 155                 160 


Ala Glu Trp Leu Leu Thr Cys Pro Val Leu Leu Ile His Leu Ser Asn 
                165                 170                 175     


Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg Thr Met Gly Leu Leu 
            180                 185                 190         


Val Ser Asp Val Gly Cys Ile Val Trp Gly Ala Thr Ser Ala Met Cys 
        195                 200                 205             


Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile Ser Leu Ser Tyr Gly 
    210                 215                 220                 


Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr Ile Glu Ala Phe His 
225                 230                 235                 240 


Thr Val Pro Lys Gly Ile Cys Arg Glu Leu Val Arg Val Met Ala Trp 
                245                 250                 255     


Thr Phe Phe Val Ala Trp Gly Met Phe Pro Val Leu Phe Leu Leu Gly 
            260                 265                 270         


Thr Glu Gly Phe Gly His Ile Ser Pro Tyr Gly Ser Ala Ile Gly His 
        275                 280                 285             


Ser Ile Leu Asp Leu Ile Ala Lys Asn Met Trp Gly Val Leu Gly Asn 
    290                 295                 300                 


Tyr Leu Arg Val Lys Ile His Glu His Ile Leu Leu Tyr Gly Asp Ile 
305                 310                 315                 320 


Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln Glu Met Glu Val Glu 
                325                 330                 335     


Thr Leu Val Ala Glu Glu Glu Asp 
            340                 


<210>  11
<211>  374
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Met Ser Arg Arg Pro Trp Leu Leu Ala Leu Ala Leu Ala Val Ala Leu 
1               5                   10                  15      


Ala Ala Gly Ser Ala Gly Ala Ser Thr Gly Ser Asp Ala Thr Val Pro 
            20                  25                  30          


Val Ala Thr Gln Asp Gly Pro Asp Tyr Val Phe His Arg Ala His Glu 
        35                  40                  45              


Arg Met Leu Phe Gln Thr Ser Tyr Thr Leu Glu Asn Asn Gly Ser Val 
    50                  55                  60                  


Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys Leu Ala Trp Leu Lys 
65                  70                  75                  80  


Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala Asn Ile Leu Gln Trp 
                85                  90                  95      


Ile Thr Phe Ala Leu Ser Ala Leu Cys Leu Met Phe Tyr Gly Tyr Gln 
            100                 105                 110         


Thr Trp Lys Ser Thr Cys Gly Trp Glu Glu Ile Tyr Val Ala Thr Ile 
        115                 120                 125             


Glu Met Ile Lys Phe Ile Ile Glu Tyr Phe His Glu Phe Asp Glu Pro 
    130                 135                 140                 


Ala Val Ile Tyr Ser Ser Asn Gly Asn Lys Thr Val Trp Leu Arg Tyr 
145                 150                 155                 160 


Ala Glu Trp Leu Leu Thr Cys Pro Val Leu Leu Ile His Leu Ser Asn 
                165                 170                 175     


Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg Thr Met Gly Leu Leu 
            180                 185                 190         


Val Ser Asp Val Gly Cys Ile Val Trp Gly Ala Thr Ser Ala Met Cys 
        195                 200                 205             


Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile Ser Leu Ser Tyr Gly 
    210                 215                 220                 


Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr Ile Glu Ala Phe His 
225                 230                 235                 240 


Thr Val Pro Lys Gly Ile Cys Arg Glu Leu Val Arg Val Met Ala Trp 
                245                 250                 255     


Thr Phe Phe Val Ala Trp Gly Met Phe Pro Val Leu Phe Leu Leu Gly 
            260                 265                 270         


Thr Glu Gly Phe Gly His Ile Ser Pro Tyr Gly Ser Ala Ile Gly His 
        275                 280                 285             


Ser Ile Leu Asp Leu Ile Ala Lys Asn Met Trp Gly Val Leu Gly Asn 
    290                 295                 300                 


Tyr Leu Arg Val Lys Ile His Glu His Ile Leu Leu Tyr Gly Asp Ile 
305                 310                 315                 320 


Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln Glu Met Glu Val Glu 
                325                 330                 335     


Thr Leu Val Ala Glu Glu Glu Asp Ala Ala Ala Lys Ser Arg Ile Thr 
            340                 345                 350         


Ser Glu Gly Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asn Val Phe 
        355                 360                 365             


Cys Tyr Glu Asn Glu Val 
    370                 


<210>  12
<211>  348
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Met Ser Arg Arg Pro Trp Leu Leu Ala Leu Ala Leu Ala Val Ala Leu 
1               5                   10                  15      


Ala Ala Gly Ser Ala Gly Ala Ser Thr Gly Ser Asp Ala Thr Val Pro 
            20                  25                  30          


Val Ala Thr Gln Asp Gly Pro Asp Tyr Val Phe His Arg Ala His Glu 
        35                  40                  45              


Arg Met Leu Phe Gln Thr Ser Tyr Thr Leu Glu Asn Asn Gly Ser Val 
    50                  55                  60                  


Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys Leu Ala Trp Leu Lys 
65                  70                  75                  80  


Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala Asn Ile Leu Gln Trp 
                85                  90                  95      


Ile Thr Phe Ala Leu Ser Ala Leu Cys Leu Met Phe Tyr Gly Tyr Gln 
            100                 105                 110         


Thr Trp Lys Ser Thr Cys Gly Trp Glu Glu Ile Tyr Val Ala Thr Ile 
        115                 120                 125             


Glu Met Ile Lys Phe Ile Ile Glu Tyr Phe His Glu Phe Asp Glu Pro 
    130                 135                 140                 


Ala Val Ile Tyr Ser Ser Asn Gly Asn Lys Thr Val Trp Leu Arg Tyr 
145                 150                 155                 160 


Ala Glu Trp Leu Leu Thr Cys Pro Val Ile Leu Ile His Leu Ser Asn 
                165                 170                 175     


Leu Thr Gly Leu Ala Asn Asp Tyr Asn Lys Arg Thr Met Gly Leu Leu 
            180                 185                 190         


Val Ser Asp Ile Gly Thr Ile Val Trp Gly Thr Thr Ala Ala Leu Ser 
        195                 200                 205             


Lys Gly Tyr Val Arg Val Ile Phe Phe Leu Met Gly Leu Cys Tyr Gly 
    210                 215                 220                 


Ile Tyr Thr Phe Phe Asn Ala Ala Lys Val Tyr Ile Glu Ala Tyr His 
225                 230                 235                 240 


Thr Val Pro Lys Gly Arg Cys Arg Gln Val Val Thr Gly Met Ala Trp 
                245                 250                 255     


Leu Phe Phe Val Ser Trp Gly Met Phe Pro Ile Leu Phe Ile Leu Gly 
            260                 265                 270         


Pro Glu Gly Phe Gly Val Leu Ser Val Tyr Gly Ser Thr Val Gly His 
        275                 280                 285             


Thr Ile Ile Asp Leu Met Ser Lys Asn Cys Trp Gly Leu Leu Gly His 
    290                 295                 300                 


Tyr Leu Arg Val Leu Ile His Glu His Ile Leu Ile His Gly Asp Ile 
305                 310                 315                 320 


Arg Lys Thr Thr Lys Leu Asn Ile Gly Gly Thr Glu Ile Glu Val Glu 
                325                 330                 335     


Thr Leu Val Glu Asp Glu Ala Glu Ala Gly Ala Val 
            340                 345             


<210>  13
<211>  378
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  13

Met Ser Arg Arg Pro Trp Leu Leu Ala Leu Ala Leu Ala Val Ala Leu 
1               5                   10                  15      


Ala Ala Gly Ser Ala Gly Ala Ser Thr Gly Ser Asp Ala Thr Val Pro 
            20                  25                  30          


Val Ala Thr Gln Asp Gly Pro Asp Tyr Val Phe His Arg Ala His Glu 
        35                  40                  45              


Arg Met Leu Phe Gln Thr Ser Tyr Thr Leu Glu Asn Asn Gly Ser Val 
    50                  55                  60                  


Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys Leu Ala Trp Leu Lys 
65                  70                  75                  80  


Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala Asn Ile Leu Gln Trp 
                85                  90                  95      


Ile Thr Phe Ala Leu Ser Ala Leu Cys Leu Met Phe Tyr Gly Tyr Gln 
            100                 105                 110         


Thr Trp Lys Ser Thr Cys Gly Trp Glu Glu Ile Tyr Val Ala Thr Ile 
        115                 120                 125             


Glu Met Ile Lys Phe Ile Ile Glu Tyr Phe His Glu Phe Asp Glu Pro 
    130                 135                 140                 


Ala Val Ile Tyr Ser Ser Asn Gly Asn Lys Thr Val Trp Leu Arg Tyr 
145                 150                 155                 160 


Ala Glu Trp Leu Leu Thr Cys Pro Val Ile Leu Ile His Leu Ser Asn 
                165                 170                 175     


Leu Thr Gly Leu Ala Asn Asp Tyr Asn Lys Arg Thr Met Gly Leu Leu 
            180                 185                 190         


Val Ser Asp Ile Gly Thr Ile Val Trp Gly Thr Thr Ala Ala Leu Ser 
        195                 200                 205             


Lys Gly Tyr Val Arg Val Ile Phe Phe Leu Met Gly Leu Cys Tyr Gly 
    210                 215                 220                 


Ile Tyr Thr Phe Phe Asn Ala Ala Lys Val Tyr Ile Glu Ala Tyr His 
225                 230                 235                 240 


Thr Val Pro Lys Gly Arg Cys Arg Gln Val Val Thr Gly Met Ala Trp 
                245                 250                 255     


Leu Phe Phe Val Ser Trp Gly Met Phe Pro Ile Leu Phe Ile Leu Gly 
            260                 265                 270         


Pro Glu Gly Phe Gly Val Leu Ser Val Tyr Gly Ser Thr Val Gly His 
        275                 280                 285             


Thr Ile Ile Asp Leu Met Ser Lys Asn Cys Trp Gly Leu Leu Gly His 
    290                 295                 300                 


Tyr Leu Arg Val Leu Ile His Glu His Ile Leu Ile His Gly Asp Ile 
305                 310                 315                 320 


Arg Lys Thr Thr Lys Leu Asn Ile Gly Gly Thr Glu Ile Glu Val Glu 
                325                 330                 335     


Thr Leu Val Glu Asp Glu Ala Glu Ala Gly Ala Val Ala Ala Ala Lys 
            340                 345                 350         


Ser Arg Ile Thr Ser Glu Gly Glu Tyr Ile Pro Leu Asp Gln Ile Asp 
        355                 360                 365             


Ile Asn Val Phe Cys Tyr Glu Asn Glu Val 
    370                 375             


<210>  14
<211>  350
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  14

Met Val Ser Arg Arg Pro Trp Leu Leu Ala Leu Ala Leu Ala Val Ala 
1               5                   10                  15      


Leu Ala Ala Gly Ser Ala Gly Ala Ser Thr Gly Ser Asp Ala Thr Val 
            20                  25                  30          


Pro Val Ala Thr Gln Asp Gly Pro Asp Tyr Val Phe His Arg Ala His 
        35                  40                  45              


Glu Arg Met Leu Phe Gln Thr Ser Tyr Thr Leu Glu Asn Asn Gly Ser 
    50                  55                  60                  


Val Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys Leu Ala Trp Leu 
65                  70                  75                  80  


Lys Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala Asn Ile Leu Gln 
                85                  90                  95      


Trp Val Thr Phe Ala Leu Ser Val Ala Cys Leu Gly Trp Tyr Ala Tyr 
            100                 105                 110         


Gln Ala Trp Arg Ala Thr Cys Gly Trp Glu Glu Val Tyr Val Ala Leu 
        115                 120                 125             


Ile Glu Met Met Lys Ser Ile Ile Glu Ala Phe His Glu Phe Asp Ser 
    130                 135                 140                 


Pro Ala Thr Leu Trp Leu Ser Ser Gly Asn Gly Val Val Trp Met Arg 
145                 150                 155                 160 


Tyr Gly Glu Trp Leu Leu Thr Cys Pro Val Ile Leu Ile His Leu Ser 
                165                 170                 175     


Asn Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg Thr Met Gly Leu 
            180                 185                 190         


Leu Val Ser Asp Val Gly Cys Ile Val Trp Gly Ala Thr Ser Ala Met 
        195                 200                 205             


Cys Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile Ser Leu Ser Tyr 
    210                 215                 220                 


Gly Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr Ile Glu Ala Phe 
225                 230                 235                 240 


His Thr Val Pro Lys Gly Leu Cys Arg Gln Leu Val Arg Ala Met Ala 
                245                 250                 255     


Trp Leu Phe Phe Val Ser Trp Gly Met Phe Pro Val Leu Phe Leu Leu 
            260                 265                 270         


Gly Pro Glu Gly Phe Gly His Ile Ser Pro Tyr Gly Ser Ala Ile Gly 
        275                 280                 285             


His Ser Ile Leu Asp Leu Ile Ala Lys Asn Met Trp Gly Val Leu Gly 
    290                 295                 300                 


Asn Tyr Leu Arg Val Lys Ile His Glu His Ile Leu Leu Tyr Gly Asp 
305                 310                 315                 320 


Ile Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln Glu Met Glu Val 
                325                 330                 335     


Glu Thr Leu Val Ala Glu Glu Glu Asp Lys Tyr Glu Ser Ser 
            340                 345                 350 


<210>  15
<211>  380
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  15

Met Val Ser Arg Arg Pro Trp Leu Leu Ala Leu Ala Leu Ala Val Ala 
1               5                   10                  15      


Leu Ala Ala Gly Ser Ala Gly Ala Ser Thr Gly Ser Asp Ala Thr Val 
            20                  25                  30          


Pro Val Ala Thr Gln Asp Gly Pro Asp Tyr Val Phe His Arg Ala His 
        35                  40                  45              


Glu Arg Met Leu Phe Gln Thr Ser Tyr Thr Leu Glu Asn Asn Gly Ser 
    50                  55                  60                  


Val Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys Leu Ala Trp Leu 
65                  70                  75                  80  


Lys Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala Asn Ile Leu Gln 
                85                  90                  95      


Trp Val Thr Phe Ala Leu Ser Val Ala Cys Leu Gly Trp Tyr Ala Tyr 
            100                 105                 110         


Gln Ala Trp Arg Ala Thr Cys Gly Trp Glu Glu Val Tyr Val Ala Leu 
        115                 120                 125             


Ile Glu Met Met Lys Ser Ile Ile Glu Ala Phe His Glu Phe Asp Ser 
    130                 135                 140                 


Pro Ala Thr Leu Trp Leu Ser Ser Gly Asn Gly Val Val Trp Met Arg 
145                 150                 155                 160 


Tyr Gly Glu Trp Leu Leu Thr Cys Pro Val Ile Leu Ile His Leu Ser 
                165                 170                 175     


Asn Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg Thr Met Gly Leu 
            180                 185                 190         


Leu Val Ser Asp Val Gly Cys Ile Val Trp Gly Ala Thr Ser Ala Met 
        195                 200                 205             


Cys Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile Ser Leu Ser Tyr 
    210                 215                 220                 


Gly Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr Ile Glu Ala Phe 
225                 230                 235                 240 


His Thr Val Pro Lys Gly Leu Cys Arg Gln Leu Val Arg Ala Met Ala 
                245                 250                 255     


Trp Leu Phe Phe Val Ser Trp Gly Met Phe Pro Val Leu Phe Leu Leu 
            260                 265                 270         


Gly Pro Glu Gly Phe Gly His Ile Ser Pro Tyr Gly Ser Ala Ile Gly 
        275                 280                 285             


His Ser Ile Leu Asp Leu Ile Ala Lys Asn Met Trp Gly Val Leu Gly 
    290                 295                 300                 


Asn Tyr Leu Arg Val Lys Ile His Glu His Ile Leu Leu Tyr Gly Asp 
305                 310                 315                 320 


Ile Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln Glu Met Glu Val 
                325                 330                 335     


Glu Thr Leu Val Ala Glu Glu Glu Asp Lys Tyr Glu Ser Ser Ala Ala 
            340                 345                 350         


Ala Lys Ser Arg Ile Thr Ser Glu Gly Glu Tyr Ile Pro Leu Asp Gln 
        355                 360                 365             


Ile Asp Ile Asn Val Phe Cys Tyr Glu Asn Glu Val 
    370                 375                 380 


<210>  16
<211>  316
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  16

Met Gly Gly Ala Pro Ala Pro Asp Ala His Ser Ala Pro Pro Gly Asn 
1               5                   10                  15      


Asp Ser Ala Gly Gly Ser Glu Tyr His Ala Pro Ala Gly Tyr Gln Val 
            20                  25                  30          


Asn Pro Pro Tyr His Pro Val His Gly Tyr Glu Glu Gln Cys Ser Ser 
        35                  40                  45              


Ile Tyr Ile Tyr Tyr Gly Ala Leu Trp Glu Gln Glu Thr Ala Arg Gly 
    50                  55                  60                  


Phe Gln Trp Phe Ala Val Phe Leu Ser Ala Leu Phe Leu Ala Phe Tyr 
65                  70                  75                  80  


Gly Trp His Ala Tyr Lys Ala Ser Val Gly Trp Glu Glu Val Tyr Val 
                85                  90                  95      


Cys Ser Val Glu Leu Ile Lys Val Ile Leu Glu Ile Tyr Phe Glu Phe 
            100                 105                 110         


Thr Ser Pro Ala Met Leu Phe Leu Tyr Gly Gly Asn Ile Thr Pro Trp 
        115                 120                 125             


Leu Arg Tyr Ala Glu Trp Leu Leu Thr Cys Pro Val Ile Leu Ile His 
    130                 135                 140                 


Leu Ser Asn Ile Thr Gly Leu Ser Glu Glu Tyr Asn Lys Arg Thr Met 
145                 150                 155                 160 


Ala Leu Leu Val Ser Asp Leu Gly Thr Ile Cys Met Gly Val Thr Ala 
                165                 170                 175     


Ala Leu Ala Thr Gly Trp Val Lys Trp Leu Phe Tyr Cys Ile Gly Leu 
            180                 185                 190         


Val Tyr Gly Thr Gln Thr Phe Tyr Asn Ala Gly Ile Ile Tyr Val Glu 
        195                 200                 205             


Ser Tyr Tyr Ile Met Pro Ala Gly Gly Cys Lys Lys Leu Val Leu Ala 
    210                 215                 220                 


Met Thr Ala Val Tyr Tyr Ser Ser Trp Leu Met Phe Pro Gly Leu Phe 
225                 230                 235                 240 


Ile Phe Gly Pro Glu Gly Met His Thr Leu Ser Val Ala Gly Ser Thr 
                245                 250                 255     


Ile Gly His Thr Ile Ala Asp Leu Leu Ser Lys Asn Ile Trp Gly Leu 
            260                 265                 270         


Leu Gly His Phe Leu Arg Ile Lys Ile His Glu His Ile Ile Met Tyr 
        275                 280                 285             


Gly Asp Ile Arg Arg Pro Val Ser Ser Gln Phe Leu Gly Arg Lys Val 
    290                 295                 300                 


Asp Val Leu Ala Phe Val Thr Glu Glu Asp Lys Val 
305                 310                 315     


<210>  17
<211>  346
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Met Gly Gly Ala Pro Ala Pro Asp Ala His Ser Ala Pro Pro Gly Asn 
1               5                   10                  15      


Asp Ser Ala Gly Gly Ser Glu Tyr His Ala Pro Ala Gly Tyr Gln Val 
            20                  25                  30          


Asn Pro Pro Tyr His Pro Val His Gly Tyr Glu Glu Gln Cys Ser Ser 
        35                  40                  45              


Ile Tyr Ile Tyr Tyr Gly Ala Leu Trp Glu Gln Glu Thr Ala Arg Gly 
    50                  55                  60                  


Phe Gln Trp Phe Ala Val Phe Leu Ser Ala Leu Phe Leu Ala Phe Tyr 
65                  70                  75                  80  


Gly Trp His Ala Tyr Lys Ala Ser Val Gly Trp Glu Glu Val Tyr Val 
                85                  90                  95      


Cys Ser Val Glu Leu Ile Lys Val Ile Leu Glu Ile Tyr Phe Glu Phe 
            100                 105                 110         


Thr Ser Pro Ala Met Leu Phe Leu Tyr Gly Gly Asn Ile Thr Pro Trp 
        115                 120                 125             


Leu Arg Tyr Ala Glu Trp Leu Leu Thr Cys Pro Val Ile Leu Ile His 
    130                 135                 140                 


Leu Ser Asn Ile Thr Gly Leu Ser Glu Glu Tyr Asn Lys Arg Thr Met 
145                 150                 155                 160 


Ala Leu Leu Val Ser Asp Leu Gly Thr Ile Cys Met Gly Val Thr Ala 
                165                 170                 175     


Ala Leu Ala Thr Gly Trp Val Lys Trp Leu Phe Tyr Cys Ile Gly Leu 
            180                 185                 190         


Val Tyr Gly Thr Gln Thr Phe Tyr Asn Ala Gly Ile Ile Tyr Val Glu 
        195                 200                 205             


Ser Tyr Tyr Ile Met Pro Ala Gly Gly Cys Lys Lys Leu Val Leu Ala 
    210                 215                 220                 


Met Thr Ala Val Tyr Tyr Ser Ser Trp Leu Met Phe Pro Gly Leu Phe 
225                 230                 235                 240 


Ile Phe Gly Pro Glu Gly Met His Thr Leu Ser Val Ala Gly Ser Thr 
                245                 250                 255     


Ile Gly His Thr Ile Ala Asp Leu Leu Ser Lys Asn Ile Trp Gly Leu 
            260                 265                 270         


Leu Gly His Phe Leu Arg Ile Lys Ile His Glu His Ile Ile Met Tyr 
        275                 280                 285             


Gly Asp Ile Arg Arg Pro Val Ser Ser Gln Phe Leu Gly Arg Lys Val 
    290                 295                 300                 


Asp Val Leu Ala Phe Val Thr Glu Glu Asp Lys Val Ala Ala Ala Lys 
305                 310                 315                 320 


Ser Arg Ile Thr Ser Glu Gly Glu Tyr Ile Pro Leu Asp Gln Ile Asp 
                325                 330                 335     


Ile Asn Val Phe Cys Tyr Glu Asn Glu Val 
            340                 345     


<210>  18
<211>  350
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  18

Met Ala Glu Leu Ile Ser Ser Ala Thr Arg Ser Leu Phe Ala Ala Gly 
1               5                   10                  15      


Gly Ile Asn Pro Trp Pro Asn Pro Tyr His His Glu Asp Met Gly Cys 
            20                  25                  30          


Gly Gly Met Thr Pro Thr Gly Glu Cys Phe Ser Thr Glu Trp Trp Cys 
        35                  40                  45              


Asp Pro Ser Tyr Gly Leu Ser Asp Ala Gly Tyr Gly Tyr Cys Phe Val 
    50                  55                  60                  


Glu Ala Thr Gly Gly Tyr Leu Val Val Gly Val Glu Lys Lys Gln Ala 
65                  70                  75                  80  


Trp Leu His Ser Arg Gly Thr Pro Gly Glu Lys Ile Gly Ala Gln Val 
                85                  90                  95      


Cys Gln Trp Ile Ala Phe Ser Ile Ala Ile Ala Leu Leu Thr Phe Tyr 
            100                 105                 110         


Gly Phe Ser Ala Trp Lys Ala Thr Cys Gly Trp Glu Glu Val Tyr Val 
        115                 120                 125             


Cys Cys Val Glu Val Leu Phe Val Thr Leu Glu Ile Phe Lys Glu Phe 
    130                 135                 140                 


Ser Ser Pro Ala Thr Val Tyr Leu Ser Thr Gly Asn His Ala Tyr Cys 
145                 150                 155                 160 


Leu Arg Tyr Phe Glu Trp Leu Leu Ser Cys Pro Val Ile Leu Ile Lys 
                165                 170                 175     


Leu Ser Asn Leu Ser Gly Leu Lys Asn Asp Tyr Ser Lys Arg Thr Met 
            180                 185                 190         


Gly Leu Ile Val Ser Cys Val Gly Met Ile Val Phe Gly Met Ala Ala 
        195                 200                 205             


Gly Leu Ala Thr Asp Trp Leu Lys Trp Leu Leu Tyr Ile Val Ser Cys 
    210                 215                 220                 


Ile Tyr Gly Gly Tyr Met Tyr Phe Gln Ala Ala Lys Cys Tyr Val Glu 
225                 230                 235                 240 


Ala Asn His Ser Val Pro Lys Gly His Cys Arg Met Val Val Lys Leu 
                245                 250                 255     


Met Ala Tyr Ala Tyr Phe Ala Ser Trp Gly Ser Tyr Pro Ile Leu Trp 
            260                 265                 270         


Ala Val Gly Pro Glu Gly Leu Leu Lys Leu Ser Pro Tyr Ala Asn Ser 
        275                 280                 285             


Ile Gly His Ser Ile Cys Asp Ile Ile Ala Lys Glu Phe Trp Thr Phe 
    290                 295                 300                 


Leu Ala His His Leu Arg Ile Lys Ile His Glu His Ile Leu Ile His 
305                 310                 315                 320 


Gly Asp Ile Arg Lys Thr Thr Lys Met Glu Ile Gly Gly Glu Glu Val 
                325                 330                 335     


Glu Val Glu Glu Phe Val Glu Glu Glu Asp Glu Asp Thr Val 
            340                 345                 350 


<210>  19
<211>  380
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  19

Met Ala Glu Leu Ile Ser Ser Ala Thr Arg Ser Leu Phe Ala Ala Gly 
1               5                   10                  15      


Gly Ile Asn Pro Trp Pro Asn Pro Tyr His His Glu Asp Met Gly Cys 
            20                  25                  30          


Gly Gly Met Thr Pro Thr Gly Glu Cys Phe Ser Thr Glu Trp Trp Cys 
        35                  40                  45              


Asp Pro Ser Tyr Gly Leu Ser Asp Ala Gly Tyr Gly Tyr Cys Phe Val 
    50                  55                  60                  


Glu Ala Thr Gly Gly Tyr Leu Val Val Gly Val Glu Lys Lys Gln Ala 
65                  70                  75                  80  


Trp Leu His Ser Arg Gly Thr Pro Gly Glu Lys Ile Gly Ala Gln Val 
                85                  90                  95      


Cys Gln Trp Ile Ala Phe Ser Ile Ala Ile Ala Leu Leu Thr Phe Tyr 
            100                 105                 110         


Gly Phe Ser Ala Trp Lys Ala Thr Cys Gly Trp Glu Glu Val Tyr Val 
        115                 120                 125             


Cys Cys Val Glu Val Leu Phe Val Thr Leu Glu Ile Phe Lys Glu Phe 
    130                 135                 140                 


Ser Ser Pro Ala Thr Val Tyr Leu Ser Thr Gly Asn His Ala Tyr Cys 
145                 150                 155                 160 


Leu Arg Tyr Phe Glu Trp Leu Leu Ser Cys Pro Val Ile Leu Ile Lys 
                165                 170                 175     


Leu Ser Asn Leu Ser Gly Leu Lys Asn Asp Tyr Ser Lys Arg Thr Met 
            180                 185                 190         


Gly Leu Ile Val Ser Cys Val Gly Met Ile Val Phe Gly Met Ala Ala 
        195                 200                 205             


Gly Leu Ala Thr Asp Trp Leu Lys Trp Leu Leu Tyr Ile Val Ser Cys 
    210                 215                 220                 


Ile Tyr Gly Gly Tyr Met Tyr Phe Gln Ala Ala Lys Cys Tyr Val Glu 
225                 230                 235                 240 


Ala Asn His Ser Val Pro Lys Gly His Cys Arg Met Val Val Lys Leu 
                245                 250                 255     


Met Ala Tyr Ala Tyr Phe Ala Ser Trp Gly Ser Tyr Pro Ile Leu Trp 
            260                 265                 270         


Ala Val Gly Pro Glu Gly Leu Leu Lys Leu Ser Pro Tyr Ala Asn Ser 
        275                 280                 285             


Ile Gly His Ser Ile Cys Asp Ile Ile Ala Lys Glu Phe Trp Thr Phe 
    290                 295                 300                 


Leu Ala His His Leu Arg Ile Lys Ile His Glu His Ile Leu Ile His 
305                 310                 315                 320 


Gly Asp Ile Arg Lys Thr Thr Lys Met Glu Ile Gly Gly Glu Glu Val 
                325                 330                 335     


Glu Val Glu Glu Phe Val Glu Glu Glu Asp Glu Asp Thr Val Ala Ala 
            340                 345                 350         


Ala Lys Ser Arg Ile Thr Ser Glu Gly Glu Tyr Ile Pro Leu Asp Gln 
        355                 360                 365             


Ile Asp Ile Asn Val Phe Cys Tyr Glu Asn Glu Val 
    370                 375                 380 


<210>  20
<211>  345
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  20

Met Ser Arg Leu Val Ala Ala Ser Trp Leu Leu Ala Leu Leu Leu Cys 
1               5                   10                  15      


Gly Ile Thr Ser Thr Thr Thr Ala Ser Ser Ala Pro Ala Ala Ser Ser 
            20                  25                  30          


Thr Asp Gly Thr Ala Ala Ala Ala Val Ser His Tyr Ala Met Asn Gly 
        35                  40                  45              


Phe Asp Glu Leu Ala Lys Gly Ala Val Val Pro Glu Asp His Phe Val 
    50                  55                  60                  


Cys Gly Pro Ala Asp Lys Cys Tyr Cys Ser Ala Trp Leu His Ser Arg 
65                  70                  75                  80  


Gly Thr Pro Gly Glu Lys Ile Gly Ala Gln Val Cys Gln Trp Ile Ala 
                85                  90                  95      


Phe Ser Ile Ala Ile Ala Leu Leu Thr Phe Tyr Gly Phe Ser Ala Trp 
            100                 105                 110         


Lys Ala Thr Cys Gly Trp Glu Glu Val Tyr Val Cys Cys Val Glu Val 
        115                 120                 125             


Leu Phe Val Thr Leu Glu Ile Phe Lys Glu Phe Ser Ser Pro Ala Thr 
    130                 135                 140                 


Val Tyr Leu Ser Thr Gly Asn His Ala Tyr Cys Leu Arg Tyr Phe Glu 
145                 150                 155                 160 


Trp Leu Leu Ser Cys Pro Val Ile Leu Ile Lys Leu Ser Asn Leu Ser 
                165                 170                 175     


Gly Leu Lys Asn Asp Tyr Ser Lys Arg Thr Met Gly Leu Ile Val Ser 
            180                 185                 190         


Cys Val Gly Met Ile Val Phe Gly Met Ala Ala Gly Leu Ala Thr Asp 
        195                 200                 205             


Trp Leu Lys Trp Leu Leu Tyr Ile Val Ser Cys Ile Tyr Gly Gly Tyr 
    210                 215                 220                 


Met Tyr Phe Gln Ala Ala Lys Cys Tyr Val Glu Ala Asn His Ser Val 
225                 230                 235                 240 


Pro Lys Gly His Cys Arg Met Val Val Lys Leu Met Ala Tyr Ala Tyr 
                245                 250                 255     


Phe Ala Ser Trp Gly Ser Tyr Pro Ile Leu Trp Ala Val Gly Pro Glu 
            260                 265                 270         


Gly Leu Leu Lys Leu Ser Pro Tyr Ala Asn Ser Ile Gly His Ser Ile 
        275                 280                 285             


Cys Asp Ile Ile Ala Lys Glu Phe Trp Thr Phe Leu Ala His His Leu 
    290                 295                 300                 


Arg Ile Lys Ile His Glu His Ile Leu Ile His Gly Asp Ile Arg Lys 
305                 310                 315                 320 


Thr Thr Lys Met Glu Ile Gly Gly Glu Glu Val Glu Val Glu Glu Phe 
                325                 330                 335     


Val Glu Glu Glu Asp Glu Asp Thr Val 
            340                 345 


<210>  21
<211>  375
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  21

Met Ser Arg Leu Val Ala Ala Ser Trp Leu Leu Ala Leu Leu Leu Cys 
1               5                   10                  15      


Gly Ile Thr Ser Thr Thr Thr Ala Ser Ser Ala Pro Ala Ala Ser Ser 
            20                  25                  30          


Thr Asp Gly Thr Ala Ala Ala Ala Val Ser His Tyr Ala Met Asn Gly 
        35                  40                  45              


Phe Asp Glu Leu Ala Lys Gly Ala Val Val Pro Glu Asp His Phe Val 
    50                  55                  60                  


Cys Gly Pro Ala Asp Lys Cys Tyr Cys Ser Ala Trp Leu His Ser Arg 
65                  70                  75                  80  


Gly Thr Pro Gly Glu Lys Ile Gly Ala Gln Val Cys Gln Trp Ile Ala 
                85                  90                  95      


Phe Ser Ile Ala Ile Ala Leu Leu Thr Phe Tyr Gly Phe Ser Ala Trp 
            100                 105                 110         


Lys Ala Thr Cys Gly Trp Glu Glu Val Tyr Val Cys Cys Val Glu Val 
        115                 120                 125             


Leu Phe Val Thr Leu Glu Ile Phe Lys Glu Phe Ser Ser Pro Ala Thr 
    130                 135                 140                 


Val Tyr Leu Ser Thr Gly Asn His Ala Tyr Cys Leu Arg Tyr Phe Glu 
145                 150                 155                 160 


Trp Leu Leu Ser Cys Pro Val Ile Leu Ile Lys Leu Ser Asn Leu Ser 
                165                 170                 175     


Gly Leu Lys Asn Asp Tyr Ser Lys Arg Thr Met Gly Leu Ile Val Ser 
            180                 185                 190         


Cys Val Gly Met Ile Val Phe Gly Met Ala Ala Gly Leu Ala Thr Asp 
        195                 200                 205             


Trp Leu Lys Trp Leu Leu Tyr Ile Val Ser Cys Ile Tyr Gly Gly Tyr 
    210                 215                 220                 


Met Tyr Phe Gln Ala Ala Lys Cys Tyr Val Glu Ala Asn His Ser Val 
225                 230                 235                 240 


Pro Lys Gly His Cys Arg Met Val Val Lys Leu Met Ala Tyr Ala Tyr 
                245                 250                 255     


Phe Ala Ser Trp Gly Ser Tyr Pro Ile Leu Trp Ala Val Gly Pro Glu 
            260                 265                 270         


Gly Leu Leu Lys Leu Ser Pro Tyr Ala Asn Ser Ile Gly His Ser Ile 
        275                 280                 285             


Cys Asp Ile Ile Ala Lys Glu Phe Trp Thr Phe Leu Ala His His Leu 
    290                 295                 300                 


Arg Ile Lys Ile His Glu His Ile Leu Ile His Gly Asp Ile Arg Lys 
305                 310                 315                 320 


Thr Thr Lys Met Glu Ile Gly Gly Glu Glu Val Glu Val Glu Glu Phe 
                325                 330                 335     


Val Glu Glu Glu Asp Glu Asp Thr Val Ala Ala Ala Lys Ser Arg Ile 
            340                 345                 350         


Thr Ser Glu Gly Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asn Val 
        355                 360                 365             


Phe Cys Tyr Glu Asn Glu Val 
    370                 375 


<210>  22
<211>  325
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  22

Met Glu Thr Ala Ala Thr Met Thr His Ala Phe Ile Ser Ala Val Pro 
1               5                   10                  15      


Ser Ala Glu Ala Thr Ile Arg Gly Leu Leu Ser Ala Ala Ala Val Val 
            20                  25                  30          


Thr Pro Ala Ala Asp Ala His Gly Glu Thr Ser Asn Ala Thr Thr Ala 
        35                  40                  45              


Gly Ala Asp His Gly Cys Phe Pro His Ile Asn His Gly Thr Glu Leu 
    50                  55                  60                  


Gln His Lys Ile Ala Val Gly Leu Gln Trp Phe Thr Val Ile Val Ala 
65                  70                  75                  80  


Ile Val Gln Leu Ile Phe Tyr Gly Trp His Ser Phe Lys Ala Thr Thr 
                85                  90                  95      


Gly Trp Glu Glu Val Tyr Val Cys Val Ile Glu Leu Val Lys Cys Phe 
            100                 105                 110         


Ile Glu Leu Phe His Glu Val Asp Ser Pro Ala Thr Val Tyr Gln Thr 
        115                 120                 125             


Asn Gly Gly Ala Val Ile Trp Leu Arg Tyr Ser Met Trp Leu Leu Thr 
    130                 135                 140                 


Cys Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr Gly Leu His Glu 
145                 150                 155                 160 


Glu Tyr Ser Lys Arg Thr Met Thr Ile Leu Val Thr Asp Ile Gly Asn 
                165                 170                 175     


Ile Val Trp Gly Ile Thr Ala Ala Phe Thr Lys Gly Pro Leu Lys Ile 
            180                 185                 190         


Leu Phe Phe Met Ile Gly Leu Phe Tyr Gly Val Thr Cys Phe Phe Gln 
        195                 200                 205             


Ile Ala Lys Val Tyr Ile Glu Ser Tyr His Thr Leu Pro Lys Gly Val 
    210                 215                 220                 


Cys Arg Lys Ile Cys Lys Ile Met Ala Tyr Val Phe Phe Cys Ser Trp 
225                 230                 235                 240 


Leu Met Phe Pro Val Met Phe Ile Ala Gly His Glu Gly Leu Gly Leu 
                245                 250                 255     


Ile Thr Pro Tyr Thr Ser Gly Ile Gly His Leu Ile Leu Asp Leu Ile 
            260                 265                 270         


Ser Lys Asn Thr Trp Gly Phe Leu Gly His His Leu Arg Val Lys Ile 
        275                 280                 285             


His Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Thr Ile 
    290                 295                 300                 


Asn Val Ala Gly Glu Asn Met Glu Ile Glu Thr Phe Val Asp Glu Glu 
305                 310                 315                 320 


Glu Glu Gly Gly Val 
                325 


<210>  23
<211>  355
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  23

Met Glu Thr Ala Ala Thr Met Thr His Ala Phe Ile Ser Ala Val Pro 
1               5                   10                  15      


Ser Ala Glu Ala Thr Ile Arg Gly Leu Leu Ser Ala Ala Ala Val Val 
            20                  25                  30          


Thr Pro Ala Ala Asp Ala His Gly Glu Thr Ser Asn Ala Thr Thr Ala 
        35                  40                  45              


Gly Ala Asp His Gly Cys Phe Pro His Ile Asn His Gly Thr Glu Leu 
    50                  55                  60                  


Gln His Lys Ile Ala Val Gly Leu Gln Trp Phe Thr Val Ile Val Ala 
65                  70                  75                  80  


Ile Val Gln Leu Ile Phe Tyr Gly Trp His Ser Phe Lys Ala Thr Thr 
                85                  90                  95      


Gly Trp Glu Glu Val Tyr Val Cys Val Ile Glu Leu Val Lys Cys Phe 
            100                 105                 110         


Ile Glu Leu Phe His Glu Val Asp Ser Pro Ala Thr Val Tyr Gln Thr 
        115                 120                 125             


Asn Gly Gly Ala Val Ile Trp Leu Arg Tyr Ser Met Trp Leu Leu Thr 
    130                 135                 140                 


Cys Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr Gly Leu His Glu 
145                 150                 155                 160 


Glu Tyr Ser Lys Arg Thr Met Thr Ile Leu Val Thr Asp Ile Gly Asn 
                165                 170                 175     


Ile Val Trp Gly Ile Thr Ala Ala Phe Thr Lys Gly Pro Leu Lys Ile 
            180                 185                 190         


Leu Phe Phe Met Ile Gly Leu Phe Tyr Gly Val Thr Cys Phe Phe Gln 
        195                 200                 205             


Ile Ala Lys Val Tyr Ile Glu Ser Tyr His Thr Leu Pro Lys Gly Val 
    210                 215                 220                 


Cys Arg Lys Ile Cys Lys Ile Met Ala Tyr Val Phe Phe Cys Ser Trp 
225                 230                 235                 240 


Leu Met Phe Pro Val Met Phe Ile Ala Gly His Glu Gly Leu Gly Leu 
                245                 250                 255     


Ile Thr Pro Tyr Thr Ser Gly Ile Gly His Leu Ile Leu Asp Leu Ile 
            260                 265                 270         


Ser Lys Asn Thr Trp Gly Phe Leu Gly His His Leu Arg Val Lys Ile 
        275                 280                 285             


His Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Thr Ile 
    290                 295                 300                 


Asn Val Ala Gly Glu Asn Met Glu Ile Glu Thr Phe Val Asp Glu Glu 
305                 310                 315                 320 


Glu Glu Gly Gly Val Ala Ala Ala Lys Ser Arg Ile Thr Ser Glu Gly 
                325                 330                 335     


Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asn Val Phe Cys Tyr Glu 
            340                 345                 350         


Asn Glu Val 
        355 


<210>  24
<211>  258
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  24

Met Asp Pro Ile Ala Leu Gln Ala Gly Tyr Asp Leu Leu Gly Asp Gly 
1               5                   10                  15      


Arg Pro Glu Thr Leu Trp Leu Gly Ile Gly Thr Leu Leu Met Leu Ile 
            20                  25                  30          


Gly Thr Phe Tyr Phe Leu Val Arg Gly Trp Gly Val Thr Asp Lys Asp 
        35                  40                  45              


Ala Arg Glu Tyr Tyr Ala Val Thr Ile Leu Val Pro Gly Ile Ala Ser 
    50                  55                  60                  


Ala Ala Tyr Leu Ser Met Phe Phe Gly Ile Gly Leu Thr Glu Val Thr 
65                  70                  75                  80  


Val Gly Gly Glu Met Leu Asp Ile Tyr Tyr Ala Arg Tyr Ala Asp Trp 
                85                  90                  95      


Leu Phe Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Ala Lys 
            100                 105                 110         


Val Asp Arg Val Thr Ile Gly Thr Leu Val Gly Val Asp Ala Leu Met 
        115                 120                 125             


Ile Val Thr Gly Leu Ile Gly Ala Leu Ser His Thr Ala Ile Ala Arg 
    130                 135                 140                 


Tyr Ser Trp Trp Leu Phe Ser Thr Ile Cys Met Ile Val Val Leu Tyr 
145                 150                 155                 160 


Phe Leu Ala Thr Ser Leu Arg Ser Ala Ala Lys Glu Arg Gly Pro Glu 
                165                 170                 175     


Val Ala Ser Thr Phe Asn Thr Leu Thr Ala Leu Val Leu Val Leu Trp 
            180                 185                 190         


Thr Ala Tyr Pro Ile Leu Trp Ile Ile Gly Thr Glu Gly Ala Gly Val 
        195                 200                 205             


Val Gly Leu Gly Ile Glu Thr Leu Leu Phe Met Val Leu Asp Val Thr 
    210                 215                 220                 


Ala Lys Val Gly Phe Gly Phe Ile Leu Leu Arg Ser Arg Ala Ile Leu 
225                 230                 235                 240 


Gly Asp Thr Glu Ala Pro Glu Pro Ser Ala Gly Ala Asp Val Ser Ala 
                245                 250                 255     


Ala Asp 
        


<210>  25
<211>  293
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  25

Met Asp Pro Ile Ala Leu Gln Ala Gly Tyr Asp Leu Leu Gly Asp Gly 
1               5                   10                  15      


Arg Pro Glu Thr Leu Trp Leu Gly Ile Gly Thr Leu Leu Met Leu Ile 
            20                  25                  30          


Gly Thr Phe Tyr Phe Leu Val Arg Gly Trp Gly Val Thr Asp Lys Asp 
        35                  40                  45              


Ala Arg Glu Tyr Tyr Ala Val Thr Ile Leu Val Pro Gly Ile Ala Ser 
    50                  55                  60                  


Ala Ala Tyr Leu Ser Met Phe Phe Gly Ile Gly Leu Thr Glu Val Thr 
65                  70                  75                  80  


Val Gly Gly Glu Met Leu Asp Ile Tyr Tyr Ala Arg Tyr Ala Asp Trp 
                85                  90                  95      


Leu Phe Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Ala Lys 
            100                 105                 110         


Val Asp Arg Val Thr Ile Gly Thr Leu Val Gly Val Asp Ala Leu Met 
        115                 120                 125             


Ile Val Thr Gly Leu Ile Gly Ala Leu Ser His Thr Ala Ile Ala Arg 
    130                 135                 140                 


Tyr Ser Trp Trp Leu Phe Ser Thr Ile Cys Met Ile Val Val Leu Tyr 
145                 150                 155                 160 


Phe Leu Ala Thr Ser Leu Arg Ser Ala Ala Lys Glu Arg Gly Pro Glu 
                165                 170                 175     


Val Ala Ser Thr Phe Asn Thr Leu Thr Ala Leu Val Leu Val Leu Trp 
            180                 185                 190         


Thr Ala Tyr Pro Ile Leu Trp Ile Ile Gly Thr Glu Gly Ala Gly Val 
        195                 200                 205             


Val Gly Leu Gly Ile Glu Thr Leu Leu Phe Met Val Leu Asp Val Thr 
    210                 215                 220                 


Ala Lys Val Gly Phe Gly Phe Ile Leu Leu Arg Ser Arg Ala Ile Leu 
225                 230                 235                 240 


Gly Asp Thr Glu Ala Pro Glu Pro Ser Ala Gly Ala Asp Val Ser Ala 
                245                 250                 255     


Ala Asp Arg Pro Val Val Ala Ala Ala Ala Lys Ser Arg Ile Thr Ser 
            260                 265                 270         


Glu Gly Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asn Val Phe Cys 
        275                 280                 285             


Tyr Glu Asn Glu Val 
    290             


<210>  26
<211>  248
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  26

Met Asp Pro Ile Ala Leu Gln Ala Gly Tyr Asp Leu Leu Gly Asp Gly 
1               5                   10                  15      


Arg Pro Glu Thr Leu Trp Leu Gly Ile Gly Thr Leu Leu Met Leu Ile 
            20                  25                  30          


Gly Thr Phe Tyr Phe Ile Val Lys Gly Trp Gly Val Thr Asp Lys Glu 
        35                  40                  45              


Ala Arg Glu Tyr Tyr Ser Ile Thr Ile Leu Val Pro Gly Ile Ala Ser 
    50                  55                  60                  


Ala Ala Tyr Leu Ser Met Phe Phe Gly Ile Gly Leu Thr Glu Val Thr 
65                  70                  75                  80  


Val Ala Gly Glu Val Leu Asp Ile Tyr Tyr Ala Arg Tyr Ala Asp Trp 
                85                  90                  95      


Leu Phe Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Ala Lys 
            100                 105                 110         


Val Asp Arg Val Ser Ile Gly Thr Leu Val Gly Val Asp Ala Leu Met 
        115                 120                 125             


Ile Val Thr Gly Leu Ile Gly Ala Leu Ser His Thr Pro Leu Ala Arg 
    130                 135                 140                 


Tyr Ser Trp Trp Leu Phe Ser Thr Ile Cys Met Ile Val Val Leu Tyr 
145                 150                 155                 160 


Phe Leu Ala Thr Ser Leu Arg Ala Ala Ala Lys Glu Arg Gly Pro Glu 
                165                 170                 175     


Val Ala Ser Thr Phe Asn Thr Leu Thr Ala Leu Val Leu Val Leu Trp 
            180                 185                 190         


Thr Ala Tyr Pro Ile Leu Trp Ile Ile Gly Thr Glu Gly Ala Gly Val 
        195                 200                 205             


Val Gly Leu Gly Ile Glu Thr Leu Leu Phe Met Val Leu Asp Val Thr 
    210                 215                 220                 


Ala Lys Val Gly Phe Gly Phe Ile Leu Leu Arg Ser Arg Ala Ile Leu 
225                 230                 235                 240 


Gly Asp Thr Glu Ala Pro Glu Pro 
                245             


<210>  27
<211>  278
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  27

Met Asp Pro Ile Ala Leu Gln Ala Gly Tyr Asp Leu Leu Gly Asp Gly 
1               5                   10                  15      


Arg Pro Glu Thr Leu Trp Leu Gly Ile Gly Thr Leu Leu Met Leu Ile 
            20                  25                  30          


Gly Thr Phe Tyr Phe Ile Val Lys Gly Trp Gly Val Thr Asp Lys Glu 
        35                  40                  45              


Ala Arg Glu Tyr Tyr Ser Ile Thr Ile Leu Val Pro Gly Ile Ala Ser 
    50                  55                  60                  


Ala Ala Tyr Leu Ser Met Phe Phe Gly Ile Gly Leu Thr Glu Val Thr 
65                  70                  75                  80  


Val Ala Gly Glu Val Leu Asp Ile Tyr Tyr Ala Arg Tyr Ala Asp Trp 
                85                  90                  95      


Leu Phe Thr Thr Pro Leu Leu Leu Leu Asp Leu Ala Leu Leu Ala Lys 
            100                 105                 110         


Val Asp Arg Val Ser Ile Gly Thr Leu Val Gly Val Asp Ala Leu Met 
        115                 120                 125             


Ile Val Thr Gly Leu Ile Gly Ala Leu Ser His Thr Pro Leu Ala Arg 
    130                 135                 140                 


Tyr Ser Trp Trp Leu Phe Ser Thr Ile Cys Met Ile Val Val Leu Tyr 
145                 150                 155                 160 


Phe Leu Ala Thr Ser Leu Arg Ala Ala Ala Lys Glu Arg Gly Pro Glu 
                165                 170                 175     


Val Ala Ser Thr Phe Asn Thr Leu Thr Ala Leu Val Leu Val Leu Trp 
            180                 185                 190         


Thr Ala Tyr Pro Ile Leu Trp Ile Ile Gly Thr Glu Gly Ala Gly Val 
        195                 200                 205             


Val Gly Leu Gly Ile Glu Thr Leu Leu Phe Met Val Leu Asp Val Thr 
    210                 215                 220                 


Ala Lys Val Gly Phe Gly Phe Ile Leu Leu Arg Ser Arg Ala Ile Leu 
225                 230                 235                 240 


Gly Asp Thr Glu Ala Pro Glu Pro Ala Ala Ala Lys Ser Arg Ile Thr 
                245                 250                 255     


Ser Glu Gly Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asn Val Phe 
            260                 265                 270         


Cys Tyr Glu Asn Glu Val 
        275             


<210>  28
<211>  242
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  28

Met Leu Val Gly Glu Gly Ala Lys Leu Asp Val His Gly Cys Lys Thr 
1               5                   10                  15      


Val Asp Met Ala Ser Ser Phe Gly Lys Ala Leu Leu Glu Phe Val Phe 
            20                  25                  30          


Ile Val Phe Ala Cys Ile Thr Leu Leu Leu Gly Ile Asn Ala Ala Lys 
        35                  40                  45              


Ser Lys Ala Ala Ser Arg Val Leu Phe Pro Ala Thr Phe Val Thr Gly 
    50                  55                  60                  


Ile Ala Ser Ile Ala Tyr Phe Ser Met Ala Ser Gly Gly Gly Trp Val 
65                  70                  75                  80  


Ile Ala Pro Asp Cys Arg Gln Leu Phe Val Ala Arg Tyr Leu Asp Trp 
                85                  90                  95      


Leu Ile Thr Thr Pro Leu Leu Leu Ile Asp Leu Gly Leu Val Ala Gly 
            100                 105                 110         


Val Ser Arg Trp Asp Ile Met Ala Leu Cys Leu Ser Asp Val Leu Met 
        115                 120                 125             


Ile Ala Thr Gly Ala Phe Gly Ser Leu Thr Val Gly Asn Val Lys Trp 
    130                 135                 140                 


Val Trp Trp Phe Phe Gly Met Cys Trp Phe Leu His Ile Ile Phe Ala 
145                 150                 155                 160 


Leu Gly Lys Ser Trp Ala Glu Ala Ala Lys Ala Lys Gly Gly Asp Ser 
                165                 170                 175     


Ala Ser Val Tyr Ser Lys Ile Ala Gly Ile Thr Val Ile Thr Trp Phe 
            180                 185                 190         


Cys Tyr Pro Val Val Trp Val Phe Ala Glu Gly Phe Gly Asn Phe Ser 
        195                 200                 205             


Val Thr Phe Glu Val Leu Ile Tyr Gly Val Leu Asp Val Ile Ser Lys 
    210                 215                 220                 


Ala Val Phe Gly Leu Ile Leu Met Ser Gly Ala Ala Thr Gly Tyr Glu 
225                 230                 235                 240 


Ser Ile 
        


<210>  29
<211>  272
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  29

Met Leu Val Gly Glu Gly Ala Lys Leu Asp Val His Gly Cys Lys Thr 
1               5                   10                  15      


Val Asp Met Ala Ser Ser Phe Gly Lys Ala Leu Leu Glu Phe Val Phe 
            20                  25                  30          


Ile Val Phe Ala Cys Ile Thr Leu Leu Leu Gly Ile Asn Ala Ala Lys 
        35                  40                  45              


Ser Lys Ala Ala Ser Arg Val Leu Phe Pro Ala Thr Phe Val Thr Gly 
    50                  55                  60                  


Ile Ala Ser Ile Ala Tyr Phe Ser Met Ala Ser Gly Gly Gly Trp Val 
65                  70                  75                  80  


Ile Ala Pro Asp Cys Arg Gln Leu Phe Val Ala Arg Tyr Leu Asp Trp 
                85                  90                  95      


Leu Ile Thr Thr Pro Leu Leu Leu Ile Asp Leu Gly Leu Val Ala Gly 
            100                 105                 110         


Val Ser Arg Trp Asp Ile Met Ala Leu Cys Leu Ser Asp Val Leu Met 
        115                 120                 125             


Ile Ala Thr Gly Ala Phe Gly Ser Leu Thr Val Gly Asn Val Lys Trp 
    130                 135                 140                 


Val Trp Trp Phe Phe Gly Met Cys Trp Phe Leu His Ile Ile Phe Ala 
145                 150                 155                 160 


Leu Gly Lys Ser Trp Ala Glu Ala Ala Lys Ala Lys Gly Gly Asp Ser 
                165                 170                 175     


Ala Ser Val Tyr Ser Lys Ile Ala Gly Ile Thr Val Ile Thr Trp Phe 
            180                 185                 190         


Cys Tyr Pro Val Val Trp Val Phe Ala Glu Gly Phe Gly Asn Phe Ser 
        195                 200                 205             


Val Thr Phe Glu Val Leu Ile Tyr Gly Val Leu Asp Val Ile Ser Lys 
    210                 215                 220                 


Ala Val Phe Gly Leu Ile Leu Met Ser Gly Ala Ala Thr Gly Tyr Glu 
225                 230                 235                 240 


Ser Ile Ala Ala Ala Lys Ser Arg Ile Thr Ser Glu Gly Glu Tyr Ile 
                245                 250                 255     


Pro Leu Asp Gln Ile Asp Ile Asn Val Phe Cys Tyr Glu Asn Glu Val 
            260                 265                 270         


<210>  30
<211>  262
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  30

Met Ala Pro Leu Ala Gln Asp Trp Thr Tyr Ala Glu Trp Ser Ala Val 
1               5                   10                  15      


Tyr Asn Ala Leu Ser Phe Gly Ile Ala Gly Met Gly Ser Ala Thr Ile 
            20                  25                  30          


Phe Phe Trp Leu Gln Leu Pro Asn Val Thr Lys Asn Tyr Arg Thr Ala 
        35                  40                  45              


Leu Thr Ile Thr Gly Ile Val Thr Leu Ile Ala Thr Tyr His Tyr Phe 
    50                  55                  60                  


Arg Ile Phe Asn Ser Trp Val Ala Ala Phe Asn Val Gly Leu Gly Val 
65                  70                  75                  80  


Asn Gly Ala Tyr Glu Val Thr Val Ser Gly Thr Pro Phe Asn Asp Ala 
                85                  90                  95      


Tyr Arg Tyr Val Asp Trp Leu Leu Thr Val Pro Leu Leu Leu Val Glu 
            100                 105                 110         


Leu Ile Leu Val Met Lys Leu Pro Ala Lys Glu Thr Val Cys Leu Ala 
        115                 120                 125             


Trp Thr Leu Gly Ile Ala Ser Ala Val Met Val Ala Leu Gly Tyr Pro 
    130                 135                 140                 


Gly Glu Ile Gln Asp Asp Leu Ser Val Arg Trp Phe Trp Trp Ala Cys 
145                 150                 155                 160 


Ala Met Val Pro Phe Val Tyr Val Val Gly Thr Leu Val Val Gly Leu 
                165                 170                 175     


Gly Ala Ala Thr Ala Lys Gln Pro Glu Gly Val Val Asp Leu Val Ser 
            180                 185                 190         


Ala Ala Arg Tyr Leu Thr Val Val Ser Trp Leu Thr Tyr Pro Phe Val 
        195                 200                 205             


Tyr Ile Val Lys Asn Ile Gly Leu Ala Gly Ser Thr Ala Thr Met Tyr 
    210                 215                 220                 


Glu Gln Ile Gly Tyr Ser Ala Ala Asp Val Thr Ala Lys Ala Val Phe 
225                 230                 235                 240 


Gly Val Leu Ile Trp Ala Ile Ala Asn Ala Lys Ser Arg Leu Glu Glu 
                245                 250                 255     


Glu Gly Lys Leu Arg Ala 
            260         


<210>  31
<211>  292
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  31

Met Ala Pro Leu Ala Gln Asp Trp Thr Tyr Ala Glu Trp Ser Ala Val 
1               5                   10                  15      


Tyr Asn Ala Leu Ser Phe Gly Ile Ala Gly Met Gly Ser Ala Thr Ile 
            20                  25                  30          


Phe Phe Trp Leu Gln Leu Pro Asn Val Thr Lys Asn Tyr Arg Thr Ala 
        35                  40                  45              


Leu Thr Ile Thr Gly Ile Val Thr Leu Ile Ala Thr Tyr His Tyr Phe 
    50                  55                  60                  


Arg Ile Phe Asn Ser Trp Val Ala Ala Phe Asn Val Gly Leu Gly Val 
65                  70                  75                  80  


Asn Gly Ala Tyr Glu Val Thr Val Ser Gly Thr Pro Phe Asn Asp Ala 
                85                  90                  95      


Tyr Arg Tyr Val Asp Trp Leu Leu Thr Val Pro Leu Leu Leu Val Glu 
            100                 105                 110         


Leu Ile Leu Val Met Lys Leu Pro Ala Lys Glu Thr Val Cys Leu Ala 
        115                 120                 125             


Trp Thr Leu Gly Ile Ala Ser Ala Val Met Val Ala Leu Gly Tyr Pro 
    130                 135                 140                 


Gly Glu Ile Gln Asp Asp Leu Ser Val Arg Trp Phe Trp Trp Ala Cys 
145                 150                 155                 160 


Ala Met Val Pro Phe Val Tyr Val Val Gly Thr Leu Val Val Gly Leu 
                165                 170                 175     


Gly Ala Ala Thr Ala Lys Gln Pro Glu Gly Val Val Asp Leu Val Ser 
            180                 185                 190         


Ala Ala Arg Tyr Leu Thr Val Val Ser Trp Leu Thr Tyr Pro Phe Val 
        195                 200                 205             


Tyr Ile Val Lys Asn Ile Gly Leu Ala Gly Ser Thr Ala Thr Met Tyr 
    210                 215                 220                 


Glu Gln Ile Gly Tyr Ser Ala Ala Asp Val Thr Ala Lys Ala Val Phe 
225                 230                 235                 240 


Gly Val Leu Ile Trp Ala Ile Ala Asn Ala Lys Ser Arg Leu Glu Glu 
                245                 250                 255     


Glu Gly Lys Leu Arg Ala Ala Ala Ala Lys Ser Arg Ile Thr Ser Glu 
            260                 265                 270         


Gly Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asn Val Phe Cys Tyr 
        275                 280                 285             


Glu Asn Glu Val 
    290         


<210>  32
<211>  313
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  32

Met Ile Val Asp Gln Phe Glu Glu Val Leu Met Lys Thr Ser Gln Leu 
1               5                   10                  15      


Phe Pro Leu Pro Thr Ala Thr Gln Ser Ala Gln Pro Thr His Val Ala 
            20                  25                  30          


Pro Val Pro Thr Val Leu Pro Asp Thr Pro Ile Tyr Glu Thr Val Gly 
        35                  40                  45              


Asp Ser Gly Ser Lys Thr Leu Trp Val Val Phe Val Leu Met Leu Ile 
    50                  55                  60                  


Ala Ser Ala Ala Phe Thr Ala Leu Ser Trp Lys Ile Pro Val Asn Arg 
65                  70                  75                  80  


Arg Leu Tyr His Val Ile Thr Thr Ile Ile Thr Leu Thr Ala Ala Leu 
                85                  90                  95      


Ser Tyr Phe Ala Met Ala Thr Gly His Gly Val Ala Leu Asn Lys Ile 
            100                 105                 110         


Val Ile Arg Thr Gln His Asp His Val Pro Asp Thr Tyr Glu Thr Val 
        115                 120                 125             


Tyr Arg Gln Val Tyr Tyr Ala Arg Tyr Ile Asp Trp Ala Ile Thr Thr 
    130                 135                 140                 


Pro Leu Leu Leu Leu Asp Leu Gly Leu Leu Ala Gly Met Ser Gly Ala 
145                 150                 155                 160 


His Ile Phe Met Ala Ile Val Ala Asp Leu Ile Met Val Leu Thr Gly 
                165                 170                 175     


Leu Phe Ala Ala Phe Gly Ser Glu Gly Thr Pro Gln Lys Trp Gly Trp 
            180                 185                 190         


Tyr Thr Ile Ala Cys Ile Ala Tyr Ile Phe Val Val Trp His Leu Val 
        195                 200                 205             


Leu Asn Gly Gly Ala Asn Ala Arg Val Lys Gly Glu Lys Leu Arg Ser 
    210                 215                 220                 


Phe Phe Val Ala Ile Gly Ala Tyr Thr Leu Ile Leu Trp Thr Ala Tyr 
225                 230                 235                 240 


Pro Ile Val Trp Gly Leu Ala Asp Gly Ala Arg Lys Ile Gly Val Asp 
                245                 250                 255     


Gly Glu Ile Ile Ala Tyr Ala Val Leu Asp Val Leu Ala Lys Gly Val 
            260                 265                 270         


Phe Gly Ala Trp Leu Leu Val Thr His Ala Asn Leu Arg Glu Ser Asp 
        275                 280                 285             


Val Glu Leu Asn Gly Phe Trp Ala Asn Gly Leu Asn Arg Glu Gly Ala 
    290                 295                 300                 


Ile Arg Ile Gly Glu Asp Asp Gly Ala 
305                 310             


<210>  33
<211>  351
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  33

Met Ile Val Asp Gln Phe Glu Glu Val Leu Met Lys Thr Ser Gln Leu 
1               5                   10                  15      


Phe Pro Leu Pro Thr Ala Thr Gln Ser Ala Gln Pro Thr His Val Ala 
            20                  25                  30          


Pro Val Pro Thr Val Leu Pro Asp Thr Pro Ile Tyr Glu Thr Val Gly 
        35                  40                  45              


Asp Ser Gly Ser Lys Thr Leu Trp Val Val Phe Val Leu Met Leu Ile 
    50                  55                  60                  


Ala Ser Ala Ala Phe Thr Ala Leu Ser Trp Lys Ile Pro Val Asn Arg 
65                  70                  75                  80  


Arg Leu Tyr His Val Ile Thr Thr Ile Ile Thr Leu Thr Ala Ala Leu 
                85                  90                  95      


Ser Tyr Phe Ala Met Ala Thr Gly His Gly Val Ala Leu Asn Lys Ile 
            100                 105                 110         


Val Ile Arg Thr Gln His Asp His Val Pro Asp Thr Tyr Glu Thr Val 
        115                 120                 125             


Tyr Arg Gln Val Tyr Tyr Ala Arg Tyr Ile Asp Trp Ala Ile Thr Thr 
    130                 135                 140                 


Pro Leu Leu Leu Leu Asp Leu Gly Leu Leu Ala Gly Met Ser Gly Ala 
145                 150                 155                 160 


His Ile Phe Met Ala Ile Val Ala Asp Leu Ile Met Val Leu Thr Gly 
                165                 170                 175     


Leu Phe Ala Ala Phe Gly Ser Glu Gly Thr Pro Gln Lys Trp Gly Trp 
            180                 185                 190         


Tyr Thr Ile Ala Cys Ile Ala Tyr Ile Phe Val Val Trp His Leu Val 
        195                 200                 205             


Leu Asn Gly Gly Ala Asn Ala Arg Val Lys Gly Glu Lys Leu Arg Ser 
    210                 215                 220                 


Phe Phe Val Ala Ile Gly Ala Tyr Thr Leu Ile Leu Trp Thr Ala Tyr 
225                 230                 235                 240 


Pro Ile Val Trp Gly Leu Ala Asp Gly Ala Arg Lys Ile Gly Val Asp 
                245                 250                 255     


Gly Glu Ile Ile Ala Tyr Ala Val Leu Asp Val Leu Ala Lys Gly Val 
            260                 265                 270         


Phe Gly Ala Trp Leu Leu Val Thr His Ala Asn Leu Arg Glu Ser Asp 
        275                 280                 285             


Val Glu Leu Asn Gly Phe Trp Ala Asn Gly Leu Asn Arg Glu Gly Ala 
    290                 295                 300                 


Ile Arg Ile Gly Glu Asp Asp Gly Ala Arg Pro Val Val Ala Val Ser 
305                 310                 315                 320 


Lys Ala Ala Ala Lys Ser Arg Ile Thr Ser Glu Gly Glu Tyr Ile Pro 
                325                 330                 335     


Leu Asp Gln Ile Asp Ile Asn Val Phe Cys Tyr Glu Asn Glu Val 
            340                 345                 350     


<210>  34
<211>  291
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  34

Met Thr Glu Thr Leu Pro Pro Val Thr Glu Ser Ala Val Ala Leu Gln 
1               5                   10                  15      


Ala Glu Val Thr Gln Arg Glu Leu Phe Glu Phe Val Leu Asn Asp Pro 
            20                  25                  30          


Leu Leu Ala Ser Ser Leu Tyr Ile Asn Ile Ala Leu Ala Gly Leu Ser 
        35                  40                  45              


Ile Leu Leu Phe Val Phe Met Thr Arg Gly Leu Asp Asp Pro Arg Ala 
    50                  55                  60                  


Lys Leu Ile Ala Val Ser Thr Ile Leu Val Pro Val Val Ser Ile Ala 
65                  70                  75                  80  


Ser Tyr Thr Gly Leu Ala Ser Gly Leu Thr Ile Ser Val Leu Glu Met 
                85                  90                  95      


Pro Ala Gly His Phe Ala Glu Gly Ser Ser Val Met Leu Gly Gly Glu 
            100                 105                 110         


Glu Val Asp Gly Val Val Thr Met Trp Gly Arg Tyr Leu Thr Trp Ala 
        115                 120                 125             


Leu Ser Thr Pro Met Ile Leu Leu Ala Leu Gly Leu Leu Ala Gly Ser 
    130                 135                 140                 


Asn Ala Thr Lys Leu Phe Thr Ala Ile Thr Phe Asp Ile Ala Met Cys 
145                 150                 155                 160 


Val Thr Gly Leu Ala Ala Ala Leu Thr Thr Ser Ser His Leu Met Arg 
                165                 170                 175     


Trp Phe Trp Tyr Ala Ile Ser Cys Ala Cys Phe Leu Val Val Leu Tyr 
            180                 185                 190         


Ile Leu Leu Val Glu Trp Ala Gln Asp Ala Lys Ala Ala Gly Thr Ala 
        195                 200                 205             


Asp Met Phe Asn Thr Leu Lys Leu Leu Thr Val Val Met Trp Leu Gly 
    210                 215                 220                 


Tyr Pro Ile Val Trp Ala Leu Gly Val Glu Gly Ile Ala Val Leu Pro 
225                 230                 235                 240 


Val Gly Val Thr Ser Trp Gly Tyr Ser Phe Leu Asp Ile Val Ala Lys 
                245                 250                 255     


Tyr Ile Phe Ala Phe Leu Leu Leu Asn Tyr Leu Thr Ser Asn Glu Ser 
            260                 265                 270         


Val Val Ser Gly Ser Ile Leu Asp Val Pro Ser Ala Ser Gly Thr Pro 
        275                 280                 285             


Ala Asp Asp 
    290     


<210>  35
<211>  320
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  35

Met Thr Glu Thr Leu Pro Pro Val Thr Glu Ser Ala Val Ala Leu Gln 
1               5                   10                  15      


Ala Glu Val Thr Gln Arg Glu Leu Phe Glu Phe Val Leu Asn Asp Pro 
            20                  25                  30          


Leu Leu Ala Ser Ser Leu Tyr Ile Asn Ile Ala Leu Ala Gly Leu Ser 
        35                  40                  45              


Ile Leu Leu Phe Val Phe Met Thr Arg Gly Leu Asp Asp Pro Arg Ala 
    50                  55                  60                  


Lys Leu Ile Ala Val Ser Thr Ile Leu Val Pro Val Val Ser Ile Ala 
65                  70                  75                  80  


Ser Tyr Thr Gly Leu Ala Ser Gly Leu Thr Ile Ser Val Leu Glu Met 
                85                  90                  95      


Pro Ala Gly His Phe Ala Glu Gly Ser Ser Val Met Leu Gly Gly Glu 
            100                 105                 110         


Glu Val Asp Gly Val Val Thr Met Trp Gly Arg Tyr Leu Thr Trp Ala 
        115                 120                 125             


Leu Ser Thr Pro Met Ile Leu Leu Ala Leu Gly Leu Leu Ala Gly Ser 
    130                 135                 140                 


Asn Ala Thr Lys Leu Phe Thr Ala Ile Thr Phe Asp Ile Ala Met Cys 
145                 150                 155                 160 


Val Thr Gly Leu Ala Ala Ala Leu Thr Thr Ser Ser His Leu Met Arg 
                165                 170                 175     


Trp Phe Trp Tyr Ala Ile Ser Cys Ala Cys Phe Leu Val Val Leu Tyr 
            180                 185                 190         


Ile Leu Leu Val Glu Trp Ala Gln Asp Ala Lys Ala Ala Gly Thr Ala 
        195                 200                 205             


Asp Met Phe Asn Thr Leu Lys Leu Leu Thr Val Val Met Trp Leu Gly 
    210                 215                 220                 


Tyr Pro Ile Val Trp Ala Leu Gly Val Glu Gly Ile Ala Val Leu Pro 
225                 230                 235                 240 


Val Gly Val Thr Ser Trp Gly Tyr Ser Phe Leu Asp Ile Val Ala Lys 
                245                 250                 255     


Tyr Ile Phe Ala Phe Leu Leu Leu Asn Tyr Leu Thr Ser Asn Glu Ser 
            260                 265                 270         


Val Val Ser Gly Ser Ile Leu Asp Val Pro Ser Ala Ser Gly Thr Pro 
        275                 280                 285             


Ala Asp Asp Ala Ala Ala Lys Ser Arg Ile Thr Ser Glu Gly Glu Tyr 
    290                 295                 300                 


Ile Pro Leu Asp Gln Ile Asp Ile Asn Phe Cys Tyr Glu Asn Glu Val 
305                 310                 315                 320 


<210>  36
<211>  303
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  36

Met Val Thr Gln Arg Glu Leu Phe Glu Phe Val Leu Asn Asp Pro Leu 
1               5                   10                  15      


Leu Ala Ser Ser Leu Tyr Ile Asn Ile Ala Leu Ala Gly Leu Ser Ile 
            20                  25                  30          


Leu Leu Phe Val Phe Met Thr Arg Gly Leu Asp Asp Pro Arg Ala Lys 
        35                  40                  45              


Leu Ile Ala Val Ser Thr Ile Leu Val Pro Val Val Ser Ile Ala Ser 
    50                  55                  60                  


Tyr Thr Gly Leu Ala Ser Gly Leu Thr Ile Ser Val Leu Glu Met Pro 
65                  70                  75                  80  


Ala Gly His Phe Ala Glu Gly Ser Ser Val Met Leu Gly Gly Glu Glu 
                85                  90                  95      


Val Asp Gly Val Val Thr Met Trp Gly Arg Tyr Leu Thr Trp Ala Leu 
            100                 105                 110         


Ser Thr Pro Met Ile Leu Leu Ala Leu Gly Leu Leu Ala Gly Ser Asn 
        115                 120                 125             


Ala Thr Lys Leu Phe Thr Ala Ile Thr Phe Asp Ile Ala Met Cys Val 
    130                 135                 140                 


Thr Gly Leu Ala Ala Ala Leu Thr Thr Ser Ser His Leu Met Arg Trp 
145                 150                 155                 160 


Phe Trp Tyr Ala Ile Ser Cys Ala Cys Phe Leu Val Val Leu Tyr Ile 
                165                 170                 175     


Leu Leu Val Glu Trp Ala Gln Asp Ala Lys Ala Ala Gly Thr Ala Asp 
            180                 185                 190         


Met Phe Asn Thr Leu Lys Leu Leu Thr Val Val Met Trp Leu Gly Tyr 
        195                 200                 205             


Pro Ile Val Trp Ala Leu Gly Val Glu Gly Ile Ala Val Leu Pro Val 
    210                 215                 220                 


Gly Val Thr Ser Trp Gly Tyr Ser Phe Leu Asp Ile Val Ala Lys Tyr 
225                 230                 235                 240 


Ile Phe Ala Phe Leu Leu Leu Asn Tyr Leu Thr Ser Asn Glu Ser Val 
                245                 250                 255     


Val Ser Gly Ser Ile Leu Asp Val Pro Ser Ala Ser Gly Thr Pro Ala 
            260                 265                 270         


Asp Asp Ala Ala Ala Lys Ser Arg Ile Thr Ser Glu Gly Glu Tyr Ile 
        275                 280                 285             


Pro Leu Asp Gln Ile Asp Ile Asn Phe Cys Tyr Glu Asn Glu Val 
    290                 295                 300             


<210>  37
<211>  365
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  37

Met Arg Arg Arg Glu Ser Gln Leu Ala Tyr Leu Cys Leu Phe Val Leu 
1               5                   10                  15      


Ile Ala Gly Trp Ala Pro Arg Leu Thr Glu Ser Ala Pro Asp Leu Ala 
            20                  25                  30          


Glu Arg Arg Pro Pro Ser Glu Arg Asn Thr Pro Tyr Ala Asn Ile Lys 
        35                  40                  45              


Lys Val Pro Asn Ile Thr Glu Pro Asn Ala Asn Val Gln Leu Asp Gly 
    50                  55                  60                  


Trp Ala Leu Tyr Gln Asp Phe Tyr Tyr Leu Ala Gly Ser Asp Lys Glu 
65                  70                  75                  80  


Trp Val Val Gly Pro Ser Asp Gln Cys Tyr Cys Arg Ala Trp Ser Lys 
                85                  90                  95      


Ser His Gly Thr Asp Arg Glu Gly Glu Ala Ala Val Val Trp Ala Tyr 
            100                 105                 110         


Ile Val Phe Ala Ile Cys Ile Val Gln Leu Val Tyr Phe Met Phe Ala 
        115                 120                 125             


Ala Trp Lys Ala Thr Val Gly Trp Glu Glu Val Tyr Val Asn Ile Ile 
    130                 135                 140                 


Glu Leu Val His Ile Ala Leu Val Ile Trp Val Glu Phe Asp Lys Pro 
145                 150                 155                 160 


Ala Met Leu Tyr Leu Asn Asp Gly Gln Met Val Pro Trp Leu Arg Tyr 
                165                 170                 175     


Ser Ala Trp Leu Leu Ser Cys Pro Val Ile Leu Ile His Leu Ser Asn 
            180                 185                 190         


Leu Thr Gly Leu Lys Gly Asp Tyr Ser Lys Arg Thr Met Gly Leu Leu 
        195                 200                 205             


Val Ser Asp Ile Gly Thr Ile Val Phe Gly Thr Ser Ala Ala Leu Ala 
    210                 215                 220                 


Pro Pro Asn His Val Lys Val Ile Leu Phe Thr Ile Gly Leu Leu Tyr 
225                 230                 235                 240 


Gly Leu Phe Thr Phe Phe Thr Ala Ala Lys Val Tyr Ile Glu Ala Tyr 
                245                 250                 255     


His Thr Val Pro Lys Gly Gln Cys Arg Asn Leu Val Arg Ala Met Ala 
            260                 265                 270         


Trp Thr Tyr Phe Val Ser Trp Ala Met Phe Pro Ile Leu Phe Ile Leu 
        275                 280                 285             


Gly Arg Glu Gly Phe Gly His Ile Thr Tyr Phe Gly Ser Ser Ile Gly 
    290                 295                 300                 


His Phe Ile Leu Glu Ile Phe Ser Lys Asn Leu Trp Ser Leu Leu Gly 
305                 310                 315                 320 


His Gly Leu Arg Tyr Arg Ile Arg Gln His Ile Ile Ile His Gly Asn 
                325                 330                 335     


Leu Thr Lys Lys Asn Lys Ile Asn Ile Ala Gly Asp Asn Val Glu Val 
            340                 345                 350         


Glu Glu Tyr Val Asp Ser Asn Asp Lys Asp Ser Asp Val 
        355                 360                 365 


<210>  38
<211>  395
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  38

Met Arg Arg Arg Glu Ser Gln Leu Ala Tyr Leu Cys Leu Phe Val Leu 
1               5                   10                  15      


Ile Ala Gly Trp Ala Pro Arg Leu Thr Glu Ser Ala Pro Asp Leu Ala 
            20                  25                  30          


Glu Arg Arg Pro Pro Ser Glu Arg Asn Thr Pro Tyr Ala Asn Ile Lys 
        35                  40                  45              


Lys Val Pro Asn Ile Thr Glu Pro Asn Ala Asn Val Gln Leu Asp Gly 
    50                  55                  60                  


Trp Ala Leu Tyr Gln Asp Phe Tyr Tyr Leu Ala Gly Ser Asp Lys Glu 
65                  70                  75                  80  


Trp Val Val Gly Pro Ser Asp Gln Cys Tyr Cys Arg Ala Trp Ser Lys 
                85                  90                  95      


Ser His Gly Thr Asp Arg Glu Gly Glu Ala Ala Val Val Trp Ala Tyr 
            100                 105                 110         


Ile Val Phe Ala Ile Cys Ile Val Gln Leu Val Tyr Phe Met Phe Ala 
        115                 120                 125             


Ala Trp Lys Ala Thr Val Gly Trp Glu Glu Val Tyr Val Asn Ile Ile 
    130                 135                 140                 


Glu Leu Val His Ile Ala Leu Val Ile Trp Val Glu Phe Asp Lys Pro 
145                 150                 155                 160 


Ala Met Leu Tyr Leu Asn Asp Gly Gln Met Val Pro Trp Leu Arg Tyr 
                165                 170                 175     


Ser Ala Trp Leu Leu Ser Cys Pro Val Ile Leu Ile His Leu Ser Asn 
            180                 185                 190         


Leu Thr Gly Leu Lys Gly Asp Tyr Ser Lys Arg Thr Met Gly Leu Leu 
        195                 200                 205             


Val Ser Asp Ile Gly Thr Ile Val Phe Gly Thr Ser Ala Ala Leu Ala 
    210                 215                 220                 


Pro Pro Asn His Val Lys Val Ile Leu Phe Thr Ile Gly Leu Leu Tyr 
225                 230                 235                 240 


Gly Leu Phe Thr Phe Phe Thr Ala Ala Lys Val Tyr Ile Glu Ala Tyr 
                245                 250                 255     


His Thr Val Pro Lys Gly Gln Cys Arg Asn Leu Val Arg Ala Met Ala 
            260                 265                 270         


Trp Thr Tyr Phe Val Ser Trp Ala Met Phe Pro Ile Leu Phe Ile Leu 
        275                 280                 285             


Gly Arg Glu Gly Phe Gly His Ile Thr Tyr Phe Gly Ser Ser Ile Gly 
    290                 295                 300                 


His Phe Ile Leu Glu Ile Phe Ser Lys Asn Leu Trp Ser Leu Leu Gly 
305                 310                 315                 320 


His Gly Leu Arg Tyr Arg Ile Arg Gln His Ile Ile Ile His Gly Asn 
                325                 330                 335     


Leu Thr Lys Lys Asn Lys Ile Asn Ile Ala Gly Asp Asn Val Glu Val 
            340                 345                 350         


Glu Glu Tyr Val Asp Ser Asn Asp Lys Asp Ser Asp Val Ala Ala Ala 
        355                 360                 365             


Lys Ser Arg Ile Thr Ser Glu Gly Glu Tyr Ile Pro Leu Asp Gln Ile 
    370                 375                 380                 


Asp Ile Asn Val Phe Cys Tyr Glu Asn Glu Val 
385                 390                 395 


<210>  39
<211>  348
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  39

Met Ser Arg Arg Pro Trp Leu Leu Ala Leu Ala Leu Ala Val Ala Leu 
1               5                   10                  15      


Ala Ala Gly Ser Ala Gly Ala Ser Thr Gly Ser Asp Ala Thr Val Pro 
            20                  25                  30          


Val Ala Thr Gln Asp Gly Pro Asp Tyr Val Phe His Arg Ala His Glu 
        35                  40                  45              


Arg Met Leu Phe Gln Thr Ser Tyr Thr Leu Glu Asn Asn Gly Ser Val 
    50                  55                  60                  


Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys Leu Ala Trp Leu Lys 
65                  70                  75                  80  


Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala Asn Ile Leu Gln Trp 
                85                  90                  95      


Ile Ser Phe Ala Leu Ser Ala Leu Cys Leu Met Phe Tyr Gly Tyr Gln 
            100                 105                 110         


Thr Trp Lys Ser Thr Cys Gly Trp Glu Glu Ile Tyr Val Ala Thr Ile 
        115                 120                 125             


Ser Met Ile Lys Phe Ile Ile Glu Tyr Phe His Ser Phe Asp Glu Pro 
    130                 135                 140                 


Ala Val Ile Tyr Ser Ser Asn Gly Asn Lys Thr Lys Trp Leu Arg Tyr 
145                 150                 155                 160 


Ala Ser Trp Leu Leu Thr Cys Pro Val Ile Leu Ile Arg Leu Ser Asn 
                165                 170                 175     


Leu Thr Gly Leu Ala Asn Asp Tyr Asn Lys Arg Thr Met Gly Leu Leu 
            180                 185                 190         


Val Ser Asp Ile Gly Thr Ile Val Trp Gly Thr Thr Ala Ala Leu Ser 
        195                 200                 205             


Lys Gly Tyr Val Arg Val Ile Phe Phe Leu Met Gly Leu Cys Tyr Gly 
    210                 215                 220                 


Ile Tyr Thr Phe Phe Asn Ala Ala Lys Val Tyr Ile Glu Ala Tyr His 
225                 230                 235                 240 


Thr Val Pro Lys Gly Arg Cys Arg Gln Val Val Thr Gly Met Ala Trp 
                245                 250                 255     


Leu Phe Phe Val Ser Trp Gly Met Phe Pro Ile Leu Phe Ile Leu Gly 
            260                 265                 270         


Pro Glu Gly Phe Gly Val Leu Ser Lys Tyr Gly Ser Asn Val Gly His 
        275                 280                 285             


Thr Ile Ile Asp Leu Met Ser Lys Gln Cys Trp Gly Leu Leu Gly His 
    290                 295                 300                 


Tyr Leu Arg Val Leu Ile His Glu His Ile Leu Ile His Gly Asp Ile 
305                 310                 315                 320 


Arg Lys Thr Thr Lys Leu Asn Ile Gly Gly Thr Glu Ile Glu Val Glu 
                325                 330                 335     


Thr Leu Val Glu Asp Glu Ala Glu Ala Gly Ala Val 
            340                 345             


<210>  40
<211>  378
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  40

Met Ser Arg Arg Pro Trp Leu Leu Ala Leu Ala Leu Ala Val Ala Leu 
1               5                   10                  15      


Ala Ala Gly Ser Ala Gly Ala Ser Thr Gly Ser Asp Ala Thr Val Pro 
            20                  25                  30          


Val Ala Thr Gln Asp Gly Pro Asp Tyr Val Phe His Arg Ala His Glu 
        35                  40                  45              


Arg Met Leu Phe Gln Thr Ser Tyr Thr Leu Glu Asn Asn Gly Ser Val 
    50                  55                  60                  


Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys Leu Ala Trp Leu Lys 
65                  70                  75                  80  


Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala Asn Ile Leu Gln Trp 
                85                  90                  95      


Ile Ser Phe Ala Leu Ser Ala Leu Cys Leu Met Phe Tyr Gly Tyr Gln 
            100                 105                 110         


Thr Trp Lys Ser Thr Cys Gly Trp Glu Glu Ile Tyr Val Ala Thr Ile 
        115                 120                 125             


Ser Met Ile Lys Phe Ile Ile Glu Tyr Phe His Ser Phe Asp Glu Pro 
    130                 135                 140                 


Ala Val Ile Tyr Ser Ser Asn Gly Asn Lys Thr Lys Trp Leu Arg Tyr 
145                 150                 155                 160 


Ala Ser Trp Leu Leu Thr Cys Pro Val Ile Leu Ile Arg Leu Ser Asn 
                165                 170                 175     


Leu Thr Gly Leu Ala Asn Asp Tyr Asn Lys Arg Thr Met Gly Leu Leu 
            180                 185                 190         


Val Ser Asp Ile Gly Thr Ile Val Trp Gly Thr Thr Ala Ala Leu Ser 
        195                 200                 205             


Lys Gly Tyr Val Arg Val Ile Phe Phe Leu Met Gly Leu Cys Tyr Gly 
    210                 215                 220                 


Ile Tyr Thr Phe Phe Asn Ala Ala Lys Val Tyr Ile Glu Ala Tyr His 
225                 230                 235                 240 


Thr Val Pro Lys Gly Arg Cys Arg Gln Val Val Thr Gly Met Ala Trp 
                245                 250                 255     


Leu Phe Phe Val Ser Trp Gly Met Phe Pro Ile Leu Phe Ile Leu Gly 
            260                 265                 270         


Pro Glu Gly Phe Gly Val Leu Ser Lys Tyr Gly Ser Asn Val Gly His 
        275                 280                 285             


Thr Ile Ile Asp Leu Met Ser Lys Gln Cys Trp Gly Leu Leu Gly His 
    290                 295                 300                 


Tyr Leu Arg Val Leu Ile His Glu His Ile Leu Ile His Gly Asp Ile 
305                 310                 315                 320 


Arg Lys Thr Thr Lys Leu Asn Ile Gly Gly Thr Glu Ile Glu Val Glu 
                325                 330                 335     


Thr Leu Val Glu Asp Glu Ala Glu Ala Gly Ala Val Ala Ala Ala Lys 
            340                 345                 350         


Ser Arg Ile Thr Ser Glu Gly Glu Tyr Ile Pro Leu Asp Gln Ile Asp 
        355                 360                 365             


Ile Asn Val Phe Cys Tyr Glu Asn Glu Val 
    370                 375             


<210>  41
<211>  348
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<222>  (167)..(167)
<223>  Xaa can be any naturally occurring amino acid

<400>  41

Met Ser Arg Arg Pro Trp Leu Leu Ala Leu Ala Leu Ala Val Ala Leu 
1               5                   10                  15      


Ala Ala Gly Ser Ala Gly Ala Ser Thr Gly Ser Asp Ala Thr Val Pro 
            20                  25                  30          


Val Ala Thr Gln Asp Gly Pro Asp Tyr Val Phe His Arg Ala His Glu 
        35                  40                  45              


Arg Met Leu Phe Gln Thr Ser Tyr Thr Leu Glu Asn Asn Gly Ser Val 
    50                  55                  60                  


Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys Leu Ala Trp Leu Lys 
65                  70                  75                  80  


Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala Asn Ile Leu Gln Trp 
                85                  90                  95      


Ile Ser Phe Ala Leu Ser Ala Leu Cys Leu Met Phe Tyr Gly Tyr Gln 
            100                 105                 110         


Thr Trp Lys Ser Thr Cys Gly Trp Glu Glu Ile Tyr Val Ala Thr Ile 
        115                 120                 125             


Ser Met Ile Lys Phe Ile Ile Glu Tyr Phe His Ser Phe Asp Glu Pro 
    130                 135                 140                 


Ala Val Ile Tyr Ser Ser Asn Gly Asn Lys Thr Lys Trp Leu Arg Tyr 
145                 150                 155                 160 


Ala Ser Trp Leu Leu Thr Xaa Pro Val Ile Leu Ile Arg Leu Ser Asn 
                165                 170                 175     


Leu Thr Gly Leu Ala Asn Asp Tyr Asn Lys Arg Thr Met Gly Leu Leu 
            180                 185                 190         


Val Ser Asp Ile Gly Thr Ile Val Trp Gly Thr Thr Ala Ala Leu Ser 
        195                 200                 205             


Lys Gly Tyr Val Arg Val Ile Phe Phe Leu Met Gly Leu Cys Tyr Gly 
    210                 215                 220                 


Ile Tyr Thr Phe Phe Asn Ala Ala Lys Val Tyr Ile Glu Ala Tyr His 
225                 230                 235                 240 


Thr Val Pro Lys Gly Arg Cys Arg Gln Val Val Thr Gly Met Ala Trp 
                245                 250                 255     


Leu Phe Phe Val Ser Trp Gly Met Phe Pro Ile Leu Phe Ile Leu Gly 
            260                 265                 270         


Pro Glu Gly Phe Gly Val Leu Ser Lys Tyr Gly Ser Asn Val Gly His 
        275                 280                 285             


Thr Ile Ile Asp Leu Met Ser Lys Gln Cys Trp Gly Leu Leu Gly His 
    290                 295                 300                 


Tyr Leu Arg Val Leu Ile His Glu His Ile Leu Ile His Gly Asp Ile 
305                 310                 315                 320 


Arg Lys Thr Thr Lys Leu Asn Ile Gly Gly Thr Glu Ile Glu Val Glu 
                325                 330                 335     


Thr Leu Val Glu Asp Glu Ala Glu Ala Gly Ala Val 
            340                 345             


<210>  42
<211>  378
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (167)..(167)
<223>  Xaa is any amino acid.

<400>  42

Met Ser Arg Arg Pro Trp Leu Leu Ala Leu Ala Leu Ala Val Ala Leu 
1               5                   10                  15      


Ala Ala Gly Ser Ala Gly Ala Ser Thr Gly Ser Asp Ala Thr Val Pro 
            20                  25                  30          


Val Ala Thr Gln Asp Gly Pro Asp Tyr Val Phe His Arg Ala His Glu 
        35                  40                  45              


Arg Met Leu Phe Gln Thr Ser Tyr Thr Leu Glu Asn Asn Gly Ser Val 
    50                  55                  60                  


Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys Leu Ala Trp Leu Lys 
65                  70                  75                  80  


Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala Asn Ile Leu Gln Trp 
                85                  90                  95      


Ile Ser Phe Ala Leu Ser Ala Leu Cys Leu Met Phe Tyr Gly Tyr Gln 
            100                 105                 110         


Thr Trp Lys Ser Thr Cys Gly Trp Glu Glu Ile Tyr Val Ala Thr Ile 
        115                 120                 125             


Ser Met Ile Lys Phe Ile Ile Glu Tyr Phe His Ser Phe Asp Glu Pro 
    130                 135                 140                 


Ala Val Ile Tyr Ser Ser Asn Gly Asn Lys Thr Lys Trp Leu Arg Tyr 
145                 150                 155                 160 


Ala Ser Trp Leu Leu Thr Xaa Pro Val Ile Leu Ile Arg Leu Ser Asn 
                165                 170                 175     


Leu Thr Gly Leu Ala Asn Asp Tyr Asn Lys Arg Thr Met Gly Leu Leu 
            180                 185                 190         


Val Ser Asp Ile Gly Thr Ile Val Trp Gly Thr Thr Ala Ala Leu Ser 
        195                 200                 205             


Lys Gly Tyr Val Arg Val Ile Phe Phe Leu Met Gly Leu Cys Tyr Gly 
    210                 215                 220                 


Ile Tyr Thr Phe Phe Asn Ala Ala Lys Val Tyr Ile Glu Ala Tyr His 
225                 230                 235                 240 


Thr Val Pro Lys Gly Arg Cys Arg Gln Val Val Thr Gly Met Ala Trp 
                245                 250                 255     


Leu Phe Phe Val Ser Trp Gly Met Phe Pro Ile Leu Phe Ile Leu Gly 
            260                 265                 270         


Pro Glu Gly Phe Gly Val Leu Ser Lys Tyr Gly Ser Asn Val Gly His 
        275                 280                 285             


Thr Ile Ile Asp Leu Met Ser Lys Gln Cys Trp Gly Leu Leu Gly His 
    290                 295                 300                 


Tyr Leu Arg Val Leu Ile His Glu His Ile Leu Ile His Gly Asp Ile 
305                 310                 315                 320 


Arg Lys Thr Thr Lys Leu Asn Ile Gly Gly Thr Glu Ile Glu Val Glu 
                325                 330                 335     


Thr Leu Val Glu Asp Glu Ala Glu Ala Gly Ala Val Ala Ala Ala Lys 
            340                 345                 350         


Ser Arg Ile Thr Ser Glu Gly Glu Tyr Ile Pro Leu Asp Gln Ile Asp 
        355                 360                 365             


Ile Asn Val Phe Cys Tyr Glu Asn Glu Val 
    370                 375             


<210>  43
<211>  309
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  43

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Leu Phe Gln Thr Ser 
1               5                   10                  15      


Tyr Thr Leu Glu Asn Asn Gly Ser Val Ile Cys Ile Pro Asn Asn Gly 
            20                  25                  30          


Gln Cys Phe Cys Leu Ala Trp Leu Lys Ser Asn Gly Thr Asn Ala Glu 
        35                  40                  45              


Lys Leu Ala Ala Asn Ile Leu Gln Trp Ile Ser Phe Ala Leu Ser Ala 
    50                  55                  60                  


Leu Cys Leu Met Phe Tyr Gly Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Ala Thr Ile Ser Met Ile Lys Phe Ile Ile 
                85                  90                  95      


Glu Tyr Phe His Ser Phe Asp Glu Pro Ala Val Ile Tyr Ser Ser Asn 
            100                 105                 110         


Gly Asn Lys Thr Lys Trp Leu Arg Tyr Ala Ser Trp Leu Leu Thr Cys 
        115                 120                 125             


Pro Val Ile Leu Ile Arg Leu Ser Asn Leu Thr Gly Leu Ala Asn Asp 
    130                 135                 140                 


Tyr Asn Lys Arg Thr Met Gly Leu Leu Val Ser Asp Ile Gly Thr Ile 
145                 150                 155                 160 


Val Trp Gly Thr Thr Ala Ala Leu Ser Lys Gly Tyr Val Arg Val Ile 
                165                 170                 175     


Phe Phe Leu Met Gly Leu Cys Tyr Gly Ile Tyr Thr Phe Phe Asn Ala 
            180                 185                 190         


Ala Lys Val Tyr Ile Glu Ala Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Lys Tyr Gly Ser Asn Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Gln Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val 
305                 


<210>  44
<211>  339
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  44

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Leu Phe Gln Thr Ser 
1               5                   10                  15      


Tyr Thr Leu Glu Asn Asn Gly Ser Val Ile Cys Ile Pro Asn Asn Gly 
            20                  25                  30          


Gln Cys Phe Cys Leu Ala Trp Leu Lys Ser Asn Gly Thr Asn Ala Glu 
        35                  40                  45              


Lys Leu Ala Ala Asn Ile Leu Gln Trp Ile Ser Phe Ala Leu Ser Ala 
    50                  55                  60                  


Leu Cys Leu Met Phe Tyr Gly Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Ala Thr Ile Ser Met Ile Lys Phe Ile Ile 
                85                  90                  95      


Glu Tyr Phe His Ser Phe Asp Glu Pro Ala Val Ile Tyr Ser Ser Asn 
            100                 105                 110         


Gly Asn Lys Thr Lys Trp Leu Arg Tyr Ala Ser Trp Leu Leu Thr Cys 
        115                 120                 125             


Pro Val Ile Leu Ile Arg Leu Ser Asn Leu Thr Gly Leu Ala Asn Asp 
    130                 135                 140                 


Tyr Asn Lys Arg Thr Met Gly Leu Leu Val Ser Asp Ile Gly Thr Ile 
145                 150                 155                 160 


Val Trp Gly Thr Thr Ala Ala Leu Ser Lys Gly Tyr Val Arg Val Ile 
                165                 170                 175     


Phe Phe Leu Met Gly Leu Cys Tyr Gly Ile Tyr Thr Phe Phe Asn Ala 
            180                 185                 190         


Ala Lys Val Tyr Ile Glu Ala Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Lys Tyr Gly Ser Asn Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Gln Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val Ala Ala Ala Lys Ser Arg Ile Thr Ser Glu Gly 
305                 310                 315                 320 


Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asn Val Phe Cys Tyr Glu 
                325                 330                 335     


Asn Glu Val 
            


<210>  45
<211>  310
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  45

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Arg Glu Leu Leu Phe 
1               5                   10                  15      


Val Thr Asn Pro Val Val Val Asn Gly Ser Val Leu Val Pro Glu Asp 
            20                  25                  30          


Gln Cys Tyr Cys Ala Gly Trp Ile Glu Ser Arg Gly Thr Asn Gly Ala 
        35                  40                  45              


Gln Thr Ala Ser Asn Val Leu Gln Trp Leu Ser Ala Gly Phe Ser Ile 
    50                  55                  60                  


Leu Leu Leu Met Phe Tyr Ala Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Cys Ala Ile Ser Met Val Lys Val Ile Leu 
                85                  90                  95      


Glu Phe Phe Phe Ser Phe Lys Asn Pro Ser Met Leu Tyr Leu Ala Thr 
            100                 105                 110         


Gly His Arg Val Lys Trp Leu Arg Tyr Ala Ser Trp Leu Leu Thr Cys 
        115                 120                 125             


Pro Val Ile Leu Ile Arg Leu Ser Asn Leu Thr Gly Leu Ser Asn Asp 
    130                 135                 140                 


Tyr Ser Arg Arg Thr Met Gly Leu Leu Val Ser Asp Ile Gly Thr Ile 
145                 150                 155                 160 


Val Trp Gly Ala Thr Ser Ala Met Ala Thr Gly Tyr Val Lys Val Ile 
                165                 170                 175     


Phe Phe Cys Leu Gly Leu Cys Tyr Gly Ala Asn Thr Phe Phe His Ala 
            180                 185                 190         


Ala Lys Ala Tyr Ile Glu Gly Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Lys Tyr Gly Ser Asn Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Gln Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val Pro 
305                 310 


<210>  46
<211>  340
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  46

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Arg Glu Leu Leu Phe 
1               5                   10                  15      


Val Thr Asn Pro Val Val Val Asn Gly Ser Val Leu Val Pro Glu Asp 
            20                  25                  30          


Gln Cys Tyr Cys Ala Gly Trp Ile Glu Ser Arg Gly Thr Asn Gly Ala 
        35                  40                  45              


Gln Thr Ala Ser Asn Val Leu Gln Trp Leu Ser Ala Gly Phe Ser Ile 
    50                  55                  60                  


Leu Leu Leu Met Phe Tyr Ala Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Cys Ala Ile Ser Met Val Lys Val Ile Leu 
                85                  90                  95      


Glu Phe Phe Phe Ser Phe Lys Asn Pro Ser Met Leu Tyr Leu Ala Thr 
            100                 105                 110         


Gly His Arg Val Lys Trp Leu Arg Tyr Ala Ser Trp Leu Leu Thr Cys 
        115                 120                 125             


Pro Val Ile Leu Ile Arg Leu Ser Asn Leu Thr Gly Leu Ser Asn Asp 
    130                 135                 140                 


Tyr Ser Arg Arg Thr Met Gly Leu Leu Val Ser Asp Ile Gly Thr Ile 
145                 150                 155                 160 


Val Trp Gly Ala Thr Ser Ala Met Ala Thr Gly Tyr Val Lys Val Ile 
                165                 170                 175     


Phe Phe Cys Leu Gly Leu Cys Tyr Gly Ala Asn Thr Phe Phe His Ala 
            180                 185                 190         


Ala Lys Ala Tyr Ile Glu Gly Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Lys Tyr Gly Ser Asn Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Gln Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val Pro Ala Ala Ala Lys Ser Arg Ile Thr Ser Glu 
305                 310                 315                 320 


Gly Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asn Val Phe Cys Tyr 
                325                 330                 335     


Glu Asn Glu Val 
            340 


<210>  47
<211>  344
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  47

Met Ser Arg Arg Pro Trp Leu Leu Ala Leu Ala Leu Ala Val Ala Leu 
1               5                   10                  15      


Ala Ala Gly Ser Ala Gly Ala Ser Thr Gly Ser Asp Ala Thr Val Pro 
            20                  25                  30          


Val Ala Thr Gln Asp Gly Pro Asp Tyr Val Phe His Arg Ala His Glu 
        35                  40                  45              


Arg Met Leu Phe Gln Thr Ser Tyr Thr Leu Glu Asn Asn Gly Ser Val 
    50                  55                  60                  


Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys Leu Ala Trp Leu Lys 
65                  70                  75                  80  


Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala Asn Ile Leu Gln Trp 
                85                  90                  95      


Ile Ser Phe Ala Leu Ser Ala Leu Cys Leu Met Phe Tyr Gly Tyr Gln 
            100                 105                 110         


Thr Trp Lys Ser Thr Cys Gly Trp Glu Glu Ile Tyr Val Ala Thr Ile 
        115                 120                 125             


Ser Met Ile Lys Phe Ile Ile Glu Tyr Phe His Ser Phe Asp Glu Pro 
    130                 135                 140                 


Ala Val Ile Tyr Ser Ser Asn Gly Asn Lys Thr Lys Trp Leu Arg Tyr 
145                 150                 155                 160 


Ala Ser Trp Leu Leu Thr Cys Pro Val Leu Leu Ile Arg Leu Ser Asn 
                165                 170                 175     


Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg Thr Met Gly Leu Leu 
            180                 185                 190         


Val Ser Asp Val Gly Cys Ile Val Trp Gly Ala Thr Ser Ala Met Cys 
        195                 200                 205             


Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile Ser Leu Ser Tyr Gly 
    210                 215                 220                 


Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr Ile Glu Ala Phe His 
225                 230                 235                 240 


Thr Val Pro Lys Gly Ile Cys Arg Glu Leu Val Arg Val Met Ala Trp 
                245                 250                 255     


Thr Phe Phe Val Ala Trp Gly Met Phe Pro Val Leu Phe Leu Leu Gly 
            260                 265                 270         


Thr Glu Gly Phe Gly His Ile Ser Lys Tyr Gly Ser Asn Ile Gly His 
        275                 280                 285             


Ser Ile Leu Asp Leu Ile Ala Lys Gln Met Trp Gly Val Leu Gly Asn 
    290                 295                 300                 


Tyr Leu Arg Val Lys Ile His Glu His Ile Leu Leu Tyr Gly Asp Ile 
305                 310                 315                 320 


Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln Glu Met Glu Val Glu 
                325                 330                 335     


Thr Leu Val Ala Glu Glu Glu Asp 
            340                 


<210>  48
<211>  374
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  48

Met Ser Arg Arg Pro Trp Leu Leu Ala Leu Ala Leu Ala Val Ala Leu 
1               5                   10                  15      


Ala Ala Gly Ser Ala Gly Ala Ser Thr Gly Ser Asp Ala Thr Val Pro 
            20                  25                  30          


Val Ala Thr Gln Asp Gly Pro Asp Tyr Val Phe His Arg Ala His Glu 
        35                  40                  45              


Arg Met Leu Phe Gln Thr Ser Tyr Thr Leu Glu Asn Asn Gly Ser Val 
    50                  55                  60                  


Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys Leu Ala Trp Leu Lys 
65                  70                  75                  80  


Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala Asn Ile Leu Gln Trp 
                85                  90                  95      


Ile Ser Phe Ala Leu Ser Ala Leu Cys Leu Met Phe Tyr Gly Tyr Gln 
            100                 105                 110         


Thr Trp Lys Ser Thr Cys Gly Trp Glu Glu Ile Tyr Val Ala Thr Ile 
        115                 120                 125             


Ser Met Ile Lys Phe Ile Ile Glu Tyr Phe His Ser Phe Asp Glu Pro 
    130                 135                 140                 


Ala Val Ile Tyr Ser Ser Asn Gly Asn Lys Thr Lys Trp Leu Arg Tyr 
145                 150                 155                 160 


Ala Ser Trp Leu Leu Thr Cys Pro Val Leu Leu Ile Arg Leu Ser Asn 
                165                 170                 175     


Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg Thr Met Gly Leu Leu 
            180                 185                 190         


Val Ser Asp Val Gly Cys Ile Val Trp Gly Ala Thr Ser Ala Met Cys 
        195                 200                 205             


Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile Ser Leu Ser Tyr Gly 
    210                 215                 220                 


Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr Ile Glu Ala Phe His 
225                 230                 235                 240 


Thr Val Pro Lys Gly Ile Cys Arg Glu Leu Val Arg Val Met Ala Trp 
                245                 250                 255     


Thr Phe Phe Val Ala Trp Gly Met Phe Pro Val Leu Phe Leu Leu Gly 
            260                 265                 270         


Thr Glu Gly Phe Gly His Ile Ser Lys Tyr Gly Ser Asn Ile Gly His 
        275                 280                 285             


Ser Ile Leu Asp Leu Ile Ala Lys Gln Met Trp Gly Val Leu Gly Asn 
    290                 295                 300                 


Tyr Leu Arg Val Lys Ile His Glu His Ile Leu Leu Tyr Gly Asp Ile 
305                 310                 315                 320 


Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln Glu Met Glu Val Glu 
                325                 330                 335     


Thr Leu Val Ala Glu Glu Glu Asp Ala Ala Ala Lys Ser Arg Ile Thr 
            340                 345                 350         


Ser Glu Gly Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asn Val Phe 
        355                 360                 365             


Cys Tyr Glu Asn Glu Val 
    370                 


<210>  49
<211>  305
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  49

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Leu Phe Gln Thr Ser 
1               5                   10                  15      


Tyr Thr Leu Glu Asn Asn Gly Ser Val Ile Cys Ile Pro Asn Asn Gly 
            20                  25                  30          


Gln Cys Phe Cys Leu Ala Trp Leu Lys Ser Asn Gly Thr Asn Ala Glu 
        35                  40                  45              


Lys Leu Ala Ala Asn Ile Leu Gln Trp Ile Ser Phe Ala Leu Ser Ala 
    50                  55                  60                  


Leu Cys Leu Met Phe Tyr Gly Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Ala Thr Ile Ser Met Ile Lys Phe Ile Ile 
                85                  90                  95      


Glu Tyr Phe His Ser Phe Asp Glu Pro Ala Val Ile Tyr Ser Ser Asn 
            100                 105                 110         


Gly Asn Lys Thr Lys Trp Leu Arg Tyr Ala Ser Trp Leu Leu Thr Cys 
        115                 120                 125             


Pro Val Leu Leu Ile Arg Leu Ser Asn Leu Thr Gly Leu Lys Asp Asp 
    130                 135                 140                 


Tyr Ser Lys Arg Thr Met Gly Leu Leu Val Ser Asp Val Gly Cys Ile 
145                 150                 155                 160 


Val Trp Gly Ala Thr Ser Ala Met Cys Thr Gly Trp Thr Lys Ile Leu 
                165                 170                 175     


Phe Phe Leu Ile Ser Leu Ser Tyr Gly Met Tyr Thr Tyr Phe His Ala 
            180                 185                 190         


Ala Lys Val Tyr Ile Glu Ala Phe His Thr Val Pro Lys Gly Ile Cys 
        195                 200                 205             


Arg Glu Leu Val Arg Val Met Ala Trp Thr Phe Phe Val Ala Trp Gly 
    210                 215                 220                 


Met Phe Pro Val Leu Phe Leu Leu Gly Thr Glu Gly Phe Gly His Ile 
225                 230                 235                 240 


Ser Lys Tyr Gly Ser Asn Ile Gly His Ser Ile Leu Asp Leu Ile Ala 
                245                 250                 255     


Lys Gln Met Trp Gly Val Leu Gly Asn Tyr Leu Arg Val Lys Ile His 
            260                 265                 270         


Glu His Ile Leu Leu Tyr Gly Asp Ile Arg Lys Lys Gln Lys Ile Thr 
        275                 280                 285             


Ile Ala Gly Gln Glu Met Glu Val Glu Thr Leu Val Ala Glu Glu Glu 
    290                 295                 300                 


Asp 
305 


<210>  50
<211>  335
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  50

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Leu Phe Gln Thr Ser 
1               5                   10                  15      


Tyr Thr Leu Glu Asn Asn Gly Ser Val Ile Cys Ile Pro Asn Asn Gly 
            20                  25                  30          


Gln Cys Phe Cys Leu Ala Trp Leu Lys Ser Asn Gly Thr Asn Ala Glu 
        35                  40                  45              


Lys Leu Ala Ala Asn Ile Leu Gln Trp Ile Ser Phe Ala Leu Ser Ala 
    50                  55                  60                  


Leu Cys Leu Met Phe Tyr Gly Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Ala Thr Ile Ser Met Ile Lys Phe Ile Ile 
                85                  90                  95      


Glu Tyr Phe His Ser Phe Asp Glu Pro Ala Val Ile Tyr Ser Ser Asn 
            100                 105                 110         


Gly Asn Lys Thr Lys Trp Leu Arg Tyr Ala Ser Trp Leu Leu Thr Cys 
        115                 120                 125             


Pro Val Leu Leu Ile Arg Leu Ser Asn Leu Thr Gly Leu Lys Asp Asp 
    130                 135                 140                 


Tyr Ser Lys Arg Thr Met Gly Leu Leu Val Ser Asp Val Gly Cys Ile 
145                 150                 155                 160 


Val Trp Gly Ala Thr Ser Ala Met Cys Thr Gly Trp Thr Lys Ile Leu 
                165                 170                 175     


Phe Phe Leu Ile Ser Leu Ser Tyr Gly Met Tyr Thr Tyr Phe His Ala 
            180                 185                 190         


Ala Lys Val Tyr Ile Glu Ala Phe His Thr Val Pro Lys Gly Ile Cys 
        195                 200                 205             


Arg Glu Leu Val Arg Val Met Ala Trp Thr Phe Phe Val Ala Trp Gly 
    210                 215                 220                 


Met Phe Pro Val Leu Phe Leu Leu Gly Thr Glu Gly Phe Gly His Ile 
225                 230                 235                 240 


Ser Lys Tyr Gly Ser Asn Ile Gly His Ser Ile Leu Asp Leu Ile Ala 
                245                 250                 255     


Lys Gln Met Trp Gly Val Leu Gly Asn Tyr Leu Arg Val Lys Ile His 
            260                 265                 270         


Glu His Ile Leu Leu Tyr Gly Asp Ile Arg Lys Lys Gln Lys Ile Thr 
        275                 280                 285             


Ile Ala Gly Gln Glu Met Glu Val Glu Thr Leu Val Ala Glu Glu Glu 
    290                 295                 300                 


Asp Ala Ala Ala Lys Ser Arg Ile Thr Ser Glu Gly Glu Tyr Ile Pro 
305                 310                 315                 320 


Leu Asp Gln Ile Asp Ile Asn Val Phe Cys Tyr Glu Asn Glu Val 
                325                 330                 335 


<210>  51
<211>  350
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  51

Met Val Ser Arg Arg Pro Trp Leu Leu Ala Leu Ala Leu Ala Val Ala 
1               5                   10                  15      


Leu Ala Ala Gly Ser Ala Gly Ala Ser Thr Gly Ser Asp Ala Thr Val 
            20                  25                  30          


Pro Val Ala Thr Gln Asp Gly Pro Asp Tyr Val Phe His Arg Ala His 
        35                  40                  45              


Glu Arg Met Leu Phe Gln Thr Ser Tyr Thr Leu Glu Asn Asn Gly Ser 
    50                  55                  60                  


Val Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys Leu Ala Trp Leu 
65                  70                  75                  80  


Lys Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala Asn Ile Leu Gln 
                85                  90                  95      


Trp Val Ser Phe Ala Leu Ser Val Ala Cys Leu Gly Trp Tyr Ala Tyr 
            100                 105                 110         


Gln Ala Trp Arg Ala Thr Cys Gly Trp Glu Glu Val Tyr Val Ala Leu 
        115                 120                 125             


Ile Ser Met Met Lys Ser Ile Ile Glu Ala Phe His Ser Phe Asp Ser 
    130                 135                 140                 


Pro Ala Thr Leu Trp Leu Ser Ser Gly Asn Gly Val Lys Trp Met Arg 
145                 150                 155                 160 


Tyr Gly Ser Trp Leu Leu Thr Cys Pro Val Ile Leu Ile Arg Leu Ser 
                165                 170                 175     


Asn Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg Thr Met Gly Leu 
            180                 185                 190         


Leu Val Ser Asp Val Gly Cys Ile Val Trp Gly Ala Thr Ser Ala Met 
        195                 200                 205             


Cys Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile Ser Leu Ser Tyr 
    210                 215                 220                 


Gly Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr Ile Glu Ala Phe 
225                 230                 235                 240 


His Thr Val Pro Lys Gly Leu Cys Arg Gln Leu Val Arg Ala Met Ala 
                245                 250                 255     


Trp Leu Phe Phe Val Ser Trp Gly Met Phe Pro Val Leu Phe Leu Leu 
            260                 265                 270         


Gly Pro Glu Gly Phe Gly His Ile Ser Lys Tyr Gly Ser Asn Ile Gly 
        275                 280                 285             


His Ser Ile Leu Asp Leu Ile Ala Lys Gln Met Trp Gly Val Leu Gly 
    290                 295                 300                 


Asn Tyr Leu Arg Val Lys Ile His Glu His Ile Leu Leu Tyr Gly Asp 
305                 310                 315                 320 


Ile Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln Glu Met Glu Val 
                325                 330                 335     


Glu Thr Leu Val Ala Glu Glu Glu Asp Lys Tyr Glu Ser Ser 
            340                 345                 350 


<210>  52
<211>  380
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  52

Met Val Ser Arg Arg Pro Trp Leu Leu Ala Leu Ala Leu Ala Val Ala 
1               5                   10                  15      


Leu Ala Ala Gly Ser Ala Gly Ala Ser Thr Gly Ser Asp Ala Thr Val 
            20                  25                  30          


Pro Val Ala Thr Gln Asp Gly Pro Asp Tyr Val Phe His Arg Ala His 
        35                  40                  45              


Glu Arg Met Leu Phe Gln Thr Ser Tyr Thr Leu Glu Asn Asn Gly Ser 
    50                  55                  60                  


Val Ile Cys Ile Pro Asn Asn Gly Gln Cys Phe Cys Leu Ala Trp Leu 
65                  70                  75                  80  


Lys Ser Asn Gly Thr Asn Ala Glu Lys Leu Ala Ala Asn Ile Leu Gln 
                85                  90                  95      


Trp Val Ser Phe Ala Leu Ser Val Ala Cys Leu Gly Trp Tyr Ala Tyr 
            100                 105                 110         


Gln Ala Trp Arg Ala Thr Cys Gly Trp Glu Glu Val Tyr Val Ala Leu 
        115                 120                 125             


Ile Ser Met Met Lys Ser Ile Ile Glu Ala Phe His Ser Phe Asp Ser 
    130                 135                 140                 


Pro Ala Thr Leu Trp Leu Ser Ser Gly Asn Gly Val Lys Trp Met Arg 
145                 150                 155                 160 


Tyr Gly Ser Trp Leu Leu Thr Cys Pro Val Ile Leu Ile Arg Leu Ser 
                165                 170                 175     


Asn Leu Thr Gly Leu Lys Asp Asp Tyr Ser Lys Arg Thr Met Gly Leu 
            180                 185                 190         


Leu Val Ser Asp Val Gly Cys Ile Val Trp Gly Ala Thr Ser Ala Met 
        195                 200                 205             


Cys Thr Gly Trp Thr Lys Ile Leu Phe Phe Leu Ile Ser Leu Ser Tyr 
    210                 215                 220                 


Gly Met Tyr Thr Tyr Phe His Ala Ala Lys Val Tyr Ile Glu Ala Phe 
225                 230                 235                 240 


His Thr Val Pro Lys Gly Leu Cys Arg Gln Leu Val Arg Ala Met Ala 
                245                 250                 255     


Trp Leu Phe Phe Val Ser Trp Gly Met Phe Pro Val Leu Phe Leu Leu 
            260                 265                 270         


Gly Pro Glu Gly Phe Gly His Ile Ser Lys Tyr Gly Ser Asn Ile Gly 
        275                 280                 285             


His Ser Ile Leu Asp Leu Ile Ala Lys Gln Met Trp Gly Val Leu Gly 
    290                 295                 300                 


Asn Tyr Leu Arg Val Lys Ile His Glu His Ile Leu Leu Tyr Gly Asp 
305                 310                 315                 320 


Ile Arg Lys Lys Gln Lys Ile Thr Ile Ala Gly Gln Glu Met Glu Val 
                325                 330                 335     


Glu Thr Leu Val Ala Glu Glu Glu Asp Lys Tyr Glu Ser Ser Ala Ala 
            340                 345                 350         


Ala Lys Ser Arg Ile Thr Ser Glu Gly Glu Tyr Ile Pro Leu Asp Gln 
        355                 360                 365             


Ile Asp Ile Asn Val Phe Cys Tyr Glu Asn Glu Val 
    370                 375                 380 


<210>  53
<211>  310
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  53

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Leu Phe Gln Thr Ser 
1               5                   10                  15      


Tyr Thr Leu Glu Asn Asn Gly Ser Val Ile Cys Ile Pro Asn Asn Gly 
            20                  25                  30          


Gln Cys Phe Cys Leu Ala Trp Leu Lys Ser Asn Gly Thr Asn Ala Glu 
        35                  40                  45              


Lys Leu Ala Ala Asn Ile Leu Gln Trp Val Ser Phe Ala Leu Ser Val 
    50                  55                  60                  


Ala Cys Leu Gly Trp Tyr Ala Tyr Gln Ala Trp Arg Ala Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Val Tyr Val Ala Leu Ile Ser Met Met Lys Ser Ile Ile 
                85                  90                  95      


Glu Ala Phe His Ser Phe Asp Ser Pro Ala Thr Leu Trp Leu Ser Ser 
            100                 105                 110         


Gly Asn Gly Val Lys Trp Met Arg Tyr Gly Ser Trp Leu Leu Thr Cys 
        115                 120                 125             


Pro Val Ile Leu Ile Arg Leu Ser Asn Leu Thr Gly Leu Lys Asp Asp 
    130                 135                 140                 


Tyr Ser Lys Arg Thr Met Gly Leu Leu Val Ser Asp Val Gly Cys Ile 
145                 150                 155                 160 


Val Trp Gly Ala Thr Ser Ala Met Cys Thr Gly Trp Thr Lys Ile Leu 
                165                 170                 175     


Phe Phe Leu Ile Ser Leu Ser Tyr Gly Met Tyr Thr Tyr Phe His Ala 
            180                 185                 190         


Ala Lys Val Tyr Ile Glu Ala Phe His Thr Val Pro Lys Gly Leu Cys 
        195                 200                 205             


Arg Gln Leu Val Arg Ala Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Val Leu Phe Leu Leu Gly Pro Glu Gly Phe Gly His Ile 
225                 230                 235                 240 


Ser Lys Tyr Gly Ser Asn Ile Gly His Ser Ile Leu Asp Leu Ile Ala 
                245                 250                 255     


Lys Gln Met Trp Gly Val Leu Gly Asn Tyr Leu Arg Val Lys Ile His 
            260                 265                 270         


Glu His Ile Leu Leu Tyr Gly Asp Ile Arg Lys Lys Gln Lys Ile Thr 
        275                 280                 285             


Ile Ala Gly Gln Glu Met Glu Val Glu Thr Leu Val Ala Glu Glu Glu 
    290                 295                 300                 


Asp Lys Tyr Glu Ser Ser 
305                 310 


<210>  54
<211>  340
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  54

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Leu Phe Gln Thr Ser 
1               5                   10                  15      


Tyr Thr Leu Glu Asn Asn Gly Ser Val Ile Cys Ile Pro Asn Asn Gly 
            20                  25                  30          


Gln Cys Phe Cys Leu Ala Trp Leu Lys Ser Asn Gly Thr Asn Ala Glu 
        35                  40                  45              


Lys Leu Ala Ala Asn Ile Leu Gln Trp Val Ser Phe Ala Leu Ser Val 
    50                  55                  60                  


Ala Cys Leu Gly Trp Tyr Ala Tyr Gln Ala Trp Arg Ala Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Val Tyr Val Ala Leu Ile Ser Met Met Lys Ser Ile Ile 
                85                  90                  95      


Glu Ala Phe His Ser Phe Asp Ser Pro Ala Thr Leu Trp Leu Ser Ser 
            100                 105                 110         


Gly Asn Gly Val Lys Trp Met Arg Tyr Gly Ser Trp Leu Leu Thr Cys 
        115                 120                 125             


Pro Val Ile Leu Ile Arg Leu Ser Asn Leu Thr Gly Leu Lys Asp Asp 
    130                 135                 140                 


Tyr Ser Lys Arg Thr Met Gly Leu Leu Val Ser Asp Val Gly Cys Ile 
145                 150                 155                 160 


Val Trp Gly Ala Thr Ser Ala Met Cys Thr Gly Trp Thr Lys Ile Leu 
                165                 170                 175     


Phe Phe Leu Ile Ser Leu Ser Tyr Gly Met Tyr Thr Tyr Phe His Ala 
            180                 185                 190         


Ala Lys Val Tyr Ile Glu Ala Phe His Thr Val Pro Lys Gly Leu Cys 
        195                 200                 205             


Arg Gln Leu Val Arg Ala Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Val Leu Phe Leu Leu Gly Pro Glu Gly Phe Gly His Ile 
225                 230                 235                 240 


Ser Lys Tyr Gly Ser Asn Ile Gly His Ser Ile Leu Asp Leu Ile Ala 
                245                 250                 255     


Lys Gln Met Trp Gly Val Leu Gly Asn Tyr Leu Arg Val Lys Ile His 
            260                 265                 270         


Glu His Ile Leu Leu Tyr Gly Asp Ile Arg Lys Lys Gln Lys Ile Thr 
        275                 280                 285             


Ile Ala Gly Gln Glu Met Glu Val Glu Thr Leu Val Ala Glu Glu Glu 
    290                 295                 300                 


Asp Lys Tyr Glu Ser Ser Ala Ala Ala Lys Ser Arg Ile Thr Ser Glu 
305                 310                 315                 320 


Gly Glu Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asn Val Phe Cys Tyr 
                325                 330                 335     


Glu Asn Glu Val 
            340 


<210>  55
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  55

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly 
1               5                   10      


<210>  56
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  56

Lys Ser Arg Ile Thr Ser Glu Gly Glu Tyr Ile Pro Leu Asp Gln Ile 
1               5                   10                  15      


Asp Ile Asn Val 
            20  


<210>  57
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  57

Val Lys Glu Ser Leu 
1               5   


<210>  58
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  58

Val Leu Gly Ser Leu 
1               5   


<210>  59
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  59

Asn Ala Asn Ser Phe Cys Tyr Glu Asn Glu Val Ala Leu Thr Ser Lys 
1               5                   10                  15      


<210>  60
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is any amino acid.

<400>  60

Phe Xaa Tyr Glu Asn Glu 
1               5       


<210>  61
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  61

Phe Cys Tyr Glu Asn Glu Val 
1               5           


<210>  62
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  62

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Arg Glu Leu Leu Phe 
1               5                   10                  15      


Val Thr Asn Pro Val Val Val Asn Gly Ser 
            20                  25      


<210>  63
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  63

Met Ala Gly His Ser Asn Ser Met Ala Leu Phe Ser Phe Ser Leu Leu 
1               5                   10                  15      


Trp Leu Cys Ser Gly Val Leu Gly Thr Glu Phe 
            20                  25          


<210>  64
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  64

Met Gly Leu Arg Ala Leu Met Leu Trp Leu Leu Ala Ala Ala Gly Leu 
1               5                   10                  15      


Val Arg Glu Ser Leu Gln Gly 
            20              


<210>  65
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  65

Met Arg Gly Thr Pro Leu Leu Leu Val Val Ser Leu Phe Ser Leu Leu 
1               5                   10                  15      


Gln Asp 
        


<210>  66
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  66

Met Thr Glu Thr Leu Pro Pro Val Thr Glu Ser Ala Val Ala Leu Gln 
1               5                   10                  15      


Ala Glu 
        


