                         SEQUENCE LISTING

<110>  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
 
<120>  RECOMBINANT CLUSTERIN AND USE THEREOF IN THE TREATMENT AND 
       PREVENTION OF DISEASE

<130>  UTFH.P0306WO

<140>  Not Yet Assigned
<141>  2015-12-02

<150>  US 62/087,364
<151>  2014-12-04

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  1

Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn 
        35                  40                  45              


Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn 
    50                  55                  60                  


Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys 
65                  70                  75                  80  


Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys 
                85                  90                  95      


Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu 
            100                 105                 110         


Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val 
        115                 120                 125             


Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu 
    130                 135                 140                 


Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp 
145                 150                 155                 160 


Ser Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met Leu Asp Val Met 
                165                 170                 175     


Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln 
            180                 185                 190         


Asp Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro 
        195                 200                 205             


Phe Ser Leu Pro His Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg 
    210                 215                 220                 


Ile Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe 
225                 230                 235                 240 


His Ala Met Phe Gln Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln 
                245                 250                 255     


Ala Met Asp Ile His Phe His Ser Pro Ala Phe Gln His Pro Pro Thr 
            260                 265                 270         


Glu Phe Ile Arg Glu Gly Asp Asp Asp Arg Thr Val Cys Arg Glu Ile 
        275                 280                 285             


Arg His Asn Ser Thr Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys 
    290                 295                 300                 


Cys Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn Asn Pro Ser Gln 
305                 310                 315                 320 


Ala Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg 
                325                 330                 335     


Leu Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met 
            340                 345                 350         


Leu Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp 
        355                 360                 365             


Val Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr Leu 
    370                 375                 380                 


Arg Val Thr Thr Val Ala Ser His Thr Ser Asp Ser Asp Val Pro Ser 
385                 390                 395                 400 


Gly Val Thr Glu Val Val Val Lys Leu Phe Asp Ser Asp Pro Ile Thr 
                405                 410                 415     


Val Thr Val Pro Val Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu 
            420                 425                 430         


Thr Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu 
        435                 440                 445             


Glu 
    


<210>  2
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  2

Thr Trp Glu Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn 
1               5                   10                  15      


Glu Leu Gln Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu 
            20                  25                  30          


Ile Gln Asn Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu 
        35                  40                  45              


Lys Thr Asn Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala 
    50                  55                  60                  


Lys Lys Lys Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr 
65                  70                  75                  80  


Lys Leu Lys Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu 
                85                  90                  95      


Trp Glu Glu Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr 
            100                 105                 110         


Ala Arg Val Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu 
        115                 120                 125             


Glu Phe Leu Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp 
    130                 135                 140                 


Arg Ile Asp Ser Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met Leu 
145                 150                 155                 160 


Asp Val Met Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu 
                165                 170                 175     


Leu Phe Gln Asp Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr His 
            180                 185                 190         


Tyr Leu Pro Phe Ser Leu Pro His Arg Arg Pro His Phe Phe Phe Pro 
        195                 200                 205             


Lys Ser Arg Ile Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro 
    210                 215                 220                 


Leu Asn Phe His Ala Met Phe Gln Pro Phe Leu Glu Met Ile His Glu 
225                 230                 235                 240 


Ala Gln Gln Ala Met Asp Ile His Phe His Ser Pro Ala Phe Gln His 
                245                 250                 255     


Pro Pro Thr Glu Phe Ile Arg Glu Gly Asp Asp Asp Arg Thr Val Cys 
            260                 265                 270         


Arg Glu Ile Arg His Asn Ser Thr Gly Cys Leu Arg Met Lys Asp Gln 
        275                 280                 285             


Cys Asp Lys Cys Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn Asn 
    290                 295                 300                 


Pro Ser Gln Ala Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln Val 
305                 310                 315                 320 


Ala Glu Arg Leu Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr Gln 
                325                 330                 335     


Trp Lys Met Leu Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu Gln 
            340                 345                 350         


Phe Asn Trp Val Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp Gln 
        355                 360                 365             


Tyr Tyr Leu Arg Val Thr Thr Val Ala Ser His Thr Ser Asp Ser Asp 
    370                 375                 380                 


Val Pro Ser Gly Val Thr Glu Val Val Val Lys Leu Phe Asp Ser Asp 
385                 390                 395                 400 


Pro Ile Thr Val Thr Val Pro Val Glu Val Ser Arg Lys Asn Pro Lys 
                405                 410                 415     


Phe Met Glu Thr Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys Lys 
            420                 425                 430         


His Arg Glu Glu 
        435     


<210>  3
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  3

Thr Trp Glu Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn 
1               5                   10                  15      


Glu Leu Gln Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu 
            20                  25                  30          


Ile Gln Asn Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu 
        35                  40                  45              


Lys Thr Asn Glu Glu Arg Lys Thr Leu Leu Ser Asn Glu Asp Ala Leu 
    50                  55                  60                  


Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys Glu Leu Pro Gly Val 
65                  70                  75                  80  


Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu Cys Lys Pro Cys Leu 
                85                  90                  95      


Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val Cys Arg Ser Gly Ser 
            100                 105                 110         


Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu Asn Gln Ser Ser Pro 
        115                 120                 125             


Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp Ser Leu Leu Glu Asn 
    130                 135                 140                 


Asp Arg Gln Gln Thr His Met Leu Asp Val Met Gln Asp His Phe Ser 
145                 150                 155                 160 


Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln Asp Arg Phe Phe Thr 
                165                 170                 175     


Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro Phe Ser Leu Pro His 
            180                 185                 190         


Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg Ile Val Arg Ser Leu 
        195                 200                 205             


Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe His Ala Met Phe Gln 
    210                 215                 220                 


Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln Ala Met Asp Ile His 
225                 230                 235                 240 


Phe His Ser Pro Ala Phe Gln His Pro Pro Thr Glu Phe Ile Arg Glu 
                245                 250                 255     


Gly Asp Asp Asp Arg Thr Val Cys Arg Glu Ile Arg His Asn Ser Thr 
            260                 265                 270         


Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys Cys Arg Glu Ile Leu 
        275                 280                 285             


Ser Val Asp Cys Ser Thr Asn Asn Pro Ser Gln Ala Lys Leu Arg Arg 
    290                 295                 300                 


Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg Leu Thr Arg Lys Tyr 
305                 310                 315                 320 


Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met Leu Asn Thr Ser Ser 
                325                 330                 335     


Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp Val Ser Arg Leu Ala 
            340                 345                 350         


Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr Leu Arg Val Thr Thr Val 
        355                 360                 365             


Ala Ser His Thr Ser Asp Ser Asp Val Pro Ser Gly Val Thr Glu Val 
    370                 375                 380                 


Val Val Lys Leu Phe Asp Ser Asp Pro Ile Thr Val Thr Val Pro Val 
385                 390                 395                 400 


Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu Thr Val Ala Glu Lys 
                405                 410                 415     


Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu Glu 
            420                 425             


<210>  4
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  4

His His His His His His Leu Val Pro Arg Gly Ser Met Met Lys Thr 
1               5                   10                  15      


Leu Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu Ser Gly Gln Val 
            20                  25                  30          


Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln Glu Met Ser Asn 
        35                  40                  45              


Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn Ala Val Asn Gly 
    50                  55                  60                  


Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn Glu Glu Arg Lys 
65                  70                  75                  80  


Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys Lys Glu Asp Ala 
                85                  90                  95      


Leu Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys Glu Leu Pro Gly 
            100                 105                 110         


Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu Cys Lys Pro Cys 
        115                 120                 125             


Leu Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val Cys Arg Ser Gly 
    130                 135                 140                 


Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu Asn Gln Ser Ser 
145                 150                 155                 160 


Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp Ser Leu Leu Glu 
                165                 170                 175     


Asn Asp Arg Gln Gln Thr His Met Leu Asp Val Met Gln Asp His Phe 
            180                 185                 190         


Ser Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln Asp Arg Phe Phe 
        195                 200                 205             


Thr Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro Phe Ser Leu Pro 
    210                 215                 220                 


His Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg Ile Val Arg Ser 
225                 230                 235                 240 


Leu Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe His Ala Met Phe 
                245                 250                 255     


Gln Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln Ala Met Asp Ile 
            260                 265                 270         


His Phe His Ser Pro Ala Phe Gln His Pro Pro Thr Glu Phe Ile Arg 
        275                 280                 285             


Glu Gly Asp Asp Asp Arg Thr Val Cys Arg Glu Ile Arg His Asn Ser 
    290                 295                 300                 


Thr Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys Cys Arg Glu Ile 
305                 310                 315                 320 


Leu Ser Val Asp Cys Ser Thr Asn Asn Pro Ser Gln Ala Lys Leu Arg 
                325                 330                 335     


Arg Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg Leu Thr Arg Lys 
            340                 345                 350         


Tyr Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met Leu Asn Thr Ser 
        355                 360                 365             


Ser Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp Val Ser Arg Leu 
    370                 375                 380                 


Ala Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr Leu Arg Val Thr Thr 
385                 390                 395                 400 


Val Ala Ser His Thr Ser Asp Ser Asp Val Pro Ser Gly Val Thr Glu 
                405                 410                 415     


Val Val Val Lys Leu Phe Asp Ser Asp Pro Ile Thr Val Thr Val Pro 
            420                 425                 430         


Val Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu Thr Val Ala Glu 
        435                 440                 445             


Lys Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu Glu 
    450                 455                 460     


<210>  5
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  5

His His His His His His Leu Val Pro Arg Gly Ser Thr Trp Glu Ser 
1               5                   10                  15      


Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln Glu 
            20                  25                  30          


Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn Ala 
        35                  40                  45              


Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn Glu 
    50                  55                  60                  


Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys Lys 
65                  70                  75                  80  


Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys Glu 
                85                  90                  95      


Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu Cys 
            100                 105                 110         


Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val Cys 
        115                 120                 125             


Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu Asn 
    130                 135                 140                 


Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp Ser 
145                 150                 155                 160 


Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met Leu Asp Val Met Gln 
                165                 170                 175     


Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln Asp 
            180                 185                 190         


Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro Phe 
        195                 200                 205             


Ser Leu Pro His Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg Ile 
    210                 215                 220                 


Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe His 
225                 230                 235                 240 


Ala Met Phe Gln Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln Ala 
                245                 250                 255     


Met Asp Ile His Phe His Ser Pro Ala Phe Gln His Pro Pro Thr Glu 
            260                 265                 270         


Phe Ile Arg Glu Gly Asp Asp Asp Arg Thr Val Cys Arg Glu Ile Arg 
        275                 280                 285             


His Asn Ser Thr Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys Cys 
    290                 295                 300                 


Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn Asn Pro Ser Gln Ala 
305                 310                 315                 320 


Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg Leu 
                325                 330                 335     


Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met Leu 
            340                 345                 350         


Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp Val 
        355                 360                 365             


Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr Leu Arg 
    370                 375                 380                 


Val Thr Thr Val Ala Ser His Thr Ser Asp Ser Asp Val Pro Ser Gly 
385                 390                 395                 400 


Val Thr Glu Val Val Val Lys Leu Phe Asp Ser Asp Pro Ile Thr Val 
                405                 410                 415     


Thr Val Pro Val Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu Thr 
            420                 425                 430         


Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu Glu 
        435                 440                 445             


<210>  6
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  6

His His His His His His Leu Val Pro Arg Gly Ser Thr Trp Glu Ser 
1               5                   10                  15      


Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln Glu 
            20                  25                  30          


Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn Ala 
        35                  40                  45              


Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn Glu 
    50                  55                  60                  


Glu Arg Lys Thr Leu Leu Ser Asn Glu Asp Ala Leu Asn Glu Thr Arg 
65                  70                  75                  80  


Glu Ser Glu Thr Lys Leu Lys Glu Leu Pro Gly Val Cys Asn Glu Thr 
                85                  90                  95      


Met Met Ala Leu Trp Glu Glu Cys Lys Pro Cys Leu Lys Gln Thr Cys 
            100                 105                 110         


Met Lys Phe Tyr Ala Arg Val Cys Arg Ser Gly Ser Gly Leu Val Gly 
        115                 120                 125             


Arg Gln Leu Glu Glu Phe Leu Asn Gln Ser Ser Pro Phe Tyr Phe Trp 
    130                 135                 140                 


Met Asn Gly Asp Arg Ile Asp Ser Leu Leu Glu Asn Asp Arg Gln Gln 
145                 150                 155                 160 


Thr His Met Leu Asp Val Met Gln Asp His Phe Ser Arg Ala Ser Ser 
                165                 170                 175     


Ile Ile Asp Glu Leu Phe Gln Asp Arg Phe Phe Thr Arg Glu Pro Gln 
            180                 185                 190         


Asp Thr Tyr His Tyr Leu Pro Phe Ser Leu Pro His Arg Arg Pro His 
        195                 200                 205             


Phe Phe Phe Pro Lys Ser Arg Ile Val Arg Ser Leu Met Pro Phe Ser 
    210                 215                 220                 


Pro Tyr Glu Pro Leu Asn Phe His Ala Met Phe Gln Pro Phe Leu Glu 
225                 230                 235                 240 


Met Ile His Glu Ala Gln Gln Ala Met Asp Ile His Phe His Ser Pro 
                245                 250                 255     


Ala Phe Gln His Pro Pro Thr Glu Phe Ile Arg Glu Gly Asp Asp Asp 
            260                 265                 270         


Arg Thr Val Cys Arg Glu Ile Arg His Asn Ser Thr Gly Cys Leu Arg 
        275                 280                 285             


Met Lys Asp Gln Cys Asp Lys Cys Arg Glu Ile Leu Ser Val Asp Cys 
    290                 295                 300                 


Ser Thr Asn Asn Pro Ser Gln Ala Lys Leu Arg Arg Glu Leu Asp Glu 
305                 310                 315                 320 


Ser Leu Gln Val Ala Glu Arg Leu Thr Arg Lys Tyr Asn Glu Leu Leu 
                325                 330                 335     


Lys Ser Tyr Gln Trp Lys Met Leu Asn Thr Ser Ser Leu Leu Glu Gln 
            340                 345                 350         


Leu Asn Glu Gln Phe Asn Trp Val Ser Arg Leu Ala Asn Leu Thr Gln 
        355                 360                 365             


Gly Glu Asp Gln Tyr Tyr Leu Arg Val Thr Thr Val Ala Ser His Thr 
    370                 375                 380                 


Ser Asp Ser Asp Val Pro Ser Gly Val Thr Glu Val Val Val Lys Leu 
385                 390                 395                 400 


Phe Asp Ser Asp Pro Ile Thr Val Thr Val Pro Val Glu Val Ser Arg 
                405                 410                 415     


Lys Asn Pro Lys Phe Met Glu Thr Val Ala Glu Lys Ala Leu Gln Glu 
            420                 425                 430         


Tyr Arg Lys Lys His Arg Glu Glu 
        435                 440 


<210>  7
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  7

Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn 
        35                  40                  45              


Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn 
    50                  55                  60                  


Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys 
65                  70                  75                  80  


Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys 
                85                  90                  95      


Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu 
            100                 105                 110         


Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val 
        115                 120                 125             


Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu 
    130                 135                 140                 


Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp 
145                 150                 155                 160 


Ser Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met Leu Asp Val Met 
                165                 170                 175     


Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln 
            180                 185                 190         


Asp Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro 
        195                 200                 205             


Phe Ser Leu Pro His Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg 
    210                 215                 220                 


Ile Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe 
225                 230                 235                 240 


His Ala Met Phe Gln Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln 
                245                 250                 255     


Ala Met Asp Ile His Phe His Ser Pro Ala Phe Gln His Pro Pro Thr 
            260                 265                 270         


Glu Phe Ile Arg Glu Gly Asp Asp Asp Arg Thr Val Cys Arg Glu Ile 
        275                 280                 285             


Arg His Asn Ser Thr Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys 
    290                 295                 300                 


Cys Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn Asn Pro Ser Gln 
305                 310                 315                 320 


Ala Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg 
                325                 330                 335     


Leu Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met 
            340                 345                 350         


Leu Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp 
        355                 360                 365             


Val Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr Leu 
    370                 375                 380                 


Arg Val Thr Thr Val Ala Ser His Thr Ser Asp Ser Asp Val Pro Ser 
385                 390                 395                 400 


Gly Val Thr Glu Val Val Val Lys Leu Phe Asp Ser Asp Pro Ile Thr 
                405                 410                 415     


Val Thr Val Pro Val Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu 
            420                 425                 430         


Thr Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu 
        435                 440                 445             


Glu Leu Val Pro Arg Gly Ser His His His His His His 
    450                 455                 460     


<210>  8
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  8

Thr Trp Glu Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn 
1               5                   10                  15      


Glu Leu Gln Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu 
            20                  25                  30          


Ile Gln Asn Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu 
        35                  40                  45              


Lys Thr Asn Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala 
    50                  55                  60                  


Lys Lys Lys Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr 
65                  70                  75                  80  


Lys Leu Lys Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu 
                85                  90                  95      


Trp Glu Glu Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr 
            100                 105                 110         


Ala Arg Val Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu 
        115                 120                 125             


Glu Phe Leu Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp 
    130                 135                 140                 


Arg Ile Asp Ser Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met Leu 
145                 150                 155                 160 


Asp Val Met Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu 
                165                 170                 175     


Leu Phe Gln Asp Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr His 
            180                 185                 190         


Tyr Leu Pro Phe Ser Leu Pro His Arg Arg Pro His Phe Phe Phe Pro 
        195                 200                 205             


Lys Ser Arg Ile Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro 
    210                 215                 220                 


Leu Asn Phe His Ala Met Phe Gln Pro Phe Leu Glu Met Ile His Glu 
225                 230                 235                 240 


Ala Gln Gln Ala Met Asp Ile His Phe His Ser Pro Ala Phe Gln His 
                245                 250                 255     


Pro Pro Thr Glu Phe Ile Arg Glu Gly Asp Asp Asp Arg Thr Val Cys 
            260                 265                 270         


Arg Glu Ile Arg His Asn Ser Thr Gly Cys Leu Arg Met Lys Asp Gln 
        275                 280                 285             


Cys Asp Lys Cys Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn Asn 
    290                 295                 300                 


Pro Ser Gln Ala Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln Val 
305                 310                 315                 320 


Ala Glu Arg Leu Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr Gln 
                325                 330                 335     


Trp Lys Met Leu Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu Gln 
            340                 345                 350         


Phe Asn Trp Val Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp Gln 
        355                 360                 365             


Tyr Tyr Leu Arg Val Thr Thr Val Ala Ser His Thr Ser Asp Ser Asp 
    370                 375                 380                 


Val Pro Ser Gly Val Thr Glu Val Val Val Lys Leu Phe Asp Ser Asp 
385                 390                 395                 400 


Pro Ile Thr Val Thr Val Pro Val Glu Val Ser Arg Lys Asn Pro Lys 
                405                 410                 415     


Phe Met Glu Thr Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys Lys 
            420                 425                 430         


His Arg Glu Glu Leu Val Pro Arg Gly Ser His His His His His His 
        435                 440                 445             


<210>  9
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  9

Met Met Lys Thr Thr Trp Glu Ser Gly Gln Val Leu Gly Asp Gln Thr 
1               5                   10                  15      


Val Ser Asp Asn Glu Leu Gln Glu Met Ser Asn Gln Gly Ser Lys Tyr 
            20                  25                  30          


Val Asn Lys Glu Ile Gln Asn Ala Val Asn Gly Val Lys Gln Ile Lys 
        35                  40                  45              


Thr Leu Ile Glu Lys Thr Asn Glu Glu Arg Lys Thr Leu Leu Ser Asn 
    50                  55                  60                  


Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys Glu 
65                  70                  75                  80  


Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu Cys 
                85                  90                  95      


Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val Cys 
            100                 105                 110         


Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu Asn 
        115                 120                 125             


Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp Ser 
    130                 135                 140                 


Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met Leu Asp Val Met Gln 
145                 150                 155                 160 


Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln Asp 
                165                 170                 175     


Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro Phe 
            180                 185                 190         


Ser Leu Pro His Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg Ile 
        195                 200                 205             


Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe His 
    210                 215                 220                 


Ala Met Phe Gln Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln Ala 
225                 230                 235                 240 


Met Asp Ile His Phe His Ser Pro Ala Phe Gln His Pro Pro Thr Glu 
                245                 250                 255     


Phe Ile Arg Glu Gly Asp Asp Asp Arg Thr Val Cys Arg Glu Ile Arg 
            260                 265                 270         


His Asn Ser Thr Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys Cys 
        275                 280                 285             


Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn Asn Pro Ser Gln Ala 
    290                 295                 300                 


Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg Leu 
305                 310                 315                 320 


Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met Leu 
                325                 330                 335     


Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp Val 
            340                 345                 350         


Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr Leu Arg 
        355                 360                 365             


Val Thr Thr Val Ala Ser His Thr Ser Asp Ser Asp Val Pro Ser Gly 
    370                 375                 380                 


Val Thr Glu Val Val Val Lys Leu Phe Asp Ser Asp Pro Ile Thr Val 
385                 390                 395                 400 


Thr Val Pro Val Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu Thr 
                405                 410                 415     


Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu Glu 
            420                 425                 430         


Leu Val Pro Arg Gly Ser His His His His His His 
        435                 440                 


<210>  10
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  10

His His His His His His Asp Asp Asp Asp Lys Met Met Lys Thr Leu 
1               5                   10                  15      


Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu Ser Gly Gln Val Leu 
            20                  25                  30          


Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln Glu Met Ser Asn Gln 
        35                  40                  45              


Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn Ala Val Asn Gly Val 
    50                  55                  60                  


Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn Glu Glu Arg Lys Thr 
65                  70                  75                  80  


Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys Lys Glu Asp Ala Leu 
                85                  90                  95      


Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys Glu Leu Pro Gly Val 
            100                 105                 110         


Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu Cys Lys Pro Cys Leu 
        115                 120                 125             


Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val Cys Arg Ser Gly Ser 
    130                 135                 140                 


Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu Asn Gln Ser Ser Pro 
145                 150                 155                 160 


Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp Ser Leu Leu Glu Asn 
                165                 170                 175     


Asp Arg Gln Gln Thr His Met Leu Asp Val Met Gln Asp His Phe Ser 
            180                 185                 190         


Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln Asp Arg Phe Phe Thr 
        195                 200                 205             


Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro Phe Ser Leu Pro His 
    210                 215                 220                 


Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg Ile Val Arg Ser Leu 
225                 230                 235                 240 


Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe His Ala Met Phe Gln 
                245                 250                 255     


Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln Ala Met Asp Ile His 
            260                 265                 270         


Phe His Ser Pro Ala Phe Gln His Pro Pro Thr Glu Phe Ile Arg Glu 
        275                 280                 285             


Gly Asp Asp Asp Arg Thr Val Cys Arg Glu Ile Arg His Asn Ser Thr 
    290                 295                 300                 


Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys Cys Arg Glu Ile Leu 
305                 310                 315                 320 


Ser Val Asp Cys Ser Thr Asn Asn Pro Ser Gln Ala Lys Leu Arg Arg 
                325                 330                 335     


Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg Leu Thr Arg Lys Tyr 
            340                 345                 350         


Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met Leu Asn Thr Ser Ser 
        355                 360                 365             


Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp Val Ser Arg Leu Ala 
    370                 375                 380                 


Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr Leu Arg Val Thr Thr Val 
385                 390                 395                 400 


Ala Ser His Thr Ser Asp Ser Asp Val Pro Ser Gly Val Thr Glu Val 
                405                 410                 415     


Val Val Lys Leu Phe Asp Ser Asp Pro Ile Thr Val Thr Val Pro Val 
            420                 425                 430         


Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu Thr Val Ala Glu Lys 
        435                 440                 445             


Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu Glu 
    450                 455                 460 


<210>  11
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  11

His His His His His His Asp Asp Asp Asp Lys Thr Trp Glu Ser Gly 
1               5                   10                  15      


Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln Glu Met 
            20                  25                  30          


Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn Ala Val 
        35                  40                  45              


Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn Glu Glu 
    50                  55                  60                  


Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys Lys Glu 
65                  70                  75                  80  


Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys Glu Leu 
                85                  90                  95      


Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu Cys Lys 
            100                 105                 110         


Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val Cys Arg 
        115                 120                 125             


Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu Asn Gln 
    130                 135                 140                 


Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp Ser Leu 
145                 150                 155                 160 


Leu Glu Asn Asp Arg Gln Gln Thr His Met Leu Asp Val Met Gln Asp 
                165                 170                 175     


His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln Asp Arg 
            180                 185                 190         


Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro Phe Ser 
        195                 200                 205             


Leu Pro His Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg Ile Val 
    210                 215                 220                 


Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe His Ala 
225                 230                 235                 240 


Met Phe Gln Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln Ala Met 
                245                 250                 255     


Asp Ile His Phe His Ser Pro Ala Phe Gln His Pro Pro Thr Glu Phe 
            260                 265                 270         


Ile Arg Glu Gly Asp Asp Asp Arg Thr Val Cys Arg Glu Ile Arg His 
        275                 280                 285             


Asn Ser Thr Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys Cys Arg 
    290                 295                 300                 


Glu Ile Leu Ser Val Asp Cys Ser Thr Asn Asn Pro Ser Gln Ala Lys 
305                 310                 315                 320 


Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg Leu Thr 
                325                 330                 335     


Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met Leu Asn 
            340                 345                 350         


Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp Val Ser 
        355                 360                 365             


Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr Leu Arg Val 
    370                 375                 380                 


Thr Thr Val Ala Ser His Thr Ser Asp Ser Asp Val Pro Ser Gly Val 
385                 390                 395                 400 


Thr Glu Val Val Val Lys Leu Phe Asp Ser Asp Pro Ile Thr Val Thr 
                405                 410                 415     


Val Pro Val Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu Thr Val 
            420                 425                 430         


Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu Glu 
        435                 440                 445         


<210>  12
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  12

His His His His His His Asp Asp Asp Asp Lys Thr Trp Glu Ser Gly 
1               5                   10                  15      


Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln Glu Met 
            20                  25                  30          


Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn Ala Val 
        35                  40                  45              


Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn Glu Glu 
    50                  55                  60                  


Arg Lys Thr Leu Leu Ser Asn Glu Asp Ala Leu Asn Glu Thr Arg Glu 
65                  70                  75                  80  


Ser Glu Thr Lys Leu Lys Glu Leu Pro Gly Val Cys Asn Glu Thr Met 
                85                  90                  95      


Met Ala Leu Trp Glu Glu Cys Lys Pro Cys Leu Lys Gln Thr Cys Met 
            100                 105                 110         


Lys Phe Tyr Ala Arg Val Cys Arg Ser Gly Ser Gly Leu Val Gly Arg 
        115                 120                 125             


Gln Leu Glu Glu Phe Leu Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met 
    130                 135                 140                 


Asn Gly Asp Arg Ile Asp Ser Leu Leu Glu Asn Asp Arg Gln Gln Thr 
145                 150                 155                 160 


His Met Leu Asp Val Met Gln Asp His Phe Ser Arg Ala Ser Ser Ile 
                165                 170                 175     


Ile Asp Glu Leu Phe Gln Asp Arg Phe Phe Thr Arg Glu Pro Gln Asp 
            180                 185                 190         


Thr Tyr His Tyr Leu Pro Phe Ser Leu Pro His Arg Arg Pro His Phe 
        195                 200                 205             


Phe Phe Pro Lys Ser Arg Ile Val Arg Ser Leu Met Pro Phe Ser Pro 
    210                 215                 220                 


Tyr Glu Pro Leu Asn Phe His Ala Met Phe Gln Pro Phe Leu Glu Met 
225                 230                 235                 240 


Ile His Glu Ala Gln Gln Ala Met Asp Ile His Phe His Ser Pro Ala 
                245                 250                 255     


Phe Gln His Pro Pro Thr Glu Phe Ile Arg Glu Gly Asp Asp Asp Arg 
            260                 265                 270         


Thr Val Cys Arg Glu Ile Arg His Asn Ser Thr Gly Cys Leu Arg Met 
        275                 280                 285             


Lys Asp Gln Cys Asp Lys Cys Arg Glu Ile Leu Ser Val Asp Cys Ser 
    290                 295                 300                 


Thr Asn Asn Pro Ser Gln Ala Lys Leu Arg Arg Glu Leu Asp Glu Ser 
305                 310                 315                 320 


Leu Gln Val Ala Glu Arg Leu Thr Arg Lys Tyr Asn Glu Leu Leu Lys 
                325                 330                 335     


Ser Tyr Gln Trp Lys Met Leu Asn Thr Ser Ser Leu Leu Glu Gln Leu 
            340                 345                 350         


Asn Glu Gln Phe Asn Trp Val Ser Arg Leu Ala Asn Leu Thr Gln Gly 
        355                 360                 365             


Glu Asp Gln Tyr Tyr Leu Arg Val Thr Thr Val Ala Ser His Thr Ser 
    370                 375                 380                 


Asp Ser Asp Val Pro Ser Gly Val Thr Glu Val Val Val Lys Leu Phe 
385                 390                 395                 400 


Asp Ser Asp Pro Ile Thr Val Thr Val Pro Val Glu Val Ser Arg Lys 
                405                 410                 415     


Asn Pro Lys Phe Met Glu Thr Val Ala Glu Lys Ala Leu Gln Glu Tyr 
            420                 425                 430         


Arg Lys Lys His Arg Glu Glu 
        435                 


<210>  13
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  13

Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn 
        35                  40                  45              


Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn 
    50                  55                  60                  


Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys 
65                  70                  75                  80  


Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys 
                85                  90                  95      


Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu 
            100                 105                 110         


Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val 
        115                 120                 125             


Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu 
    130                 135                 140                 


Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp 
145                 150                 155                 160 


Ser Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met Leu Asp Val Met 
                165                 170                 175     


Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln 
            180                 185                 190         


Asp Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro 
        195                 200                 205             


Phe Ser Leu Pro His Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg 
    210                 215                 220                 


Ile Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe 
225                 230                 235                 240 


His Ala Met Phe Gln Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln 
                245                 250                 255     


Ala Met Asp Ile His Phe His Ser Pro Ala Phe Gln His Pro Pro Thr 
            260                 265                 270         


Glu Phe Ile Arg Glu Gly Asp Asp Asp Arg Thr Val Cys Arg Glu Ile 
        275                 280                 285             


Arg His Asn Ser Thr Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys 
    290                 295                 300                 


Cys Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn Asn Pro Ser Gln 
305                 310                 315                 320 


Ala Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg 
                325                 330                 335     


Leu Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met 
            340                 345                 350         


Leu Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp 
        355                 360                 365             


Val Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr Leu 
    370                 375                 380                 


Arg Val Thr Thr Val Ala Ser His Thr Ser Asp Ser Asp Val Pro Ser 
385                 390                 395                 400 


Gly Val Thr Glu Val Val Val Lys Leu Phe Asp Ser Asp Pro Ile Thr 
                405                 410                 415     


Val Thr Val Pro Val Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu 
            420                 425                 430         


Thr Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu 
        435                 440                 445             


Glu Leu Asp Asp Asp Asp Lys His His His His His His 
    450                 455                 460     


<210>  14
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  14

Thr Trp Glu Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn 
1               5                   10                  15      


Glu Leu Gln Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu 
            20                  25                  30          


Ile Gln Asn Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu 
        35                  40                  45              


Lys Thr Asn Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala 
    50                  55                  60                  


Lys Lys Lys Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr 
65                  70                  75                  80  


Lys Leu Lys Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu 
                85                  90                  95      


Trp Glu Glu Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr 
            100                 105                 110         


Ala Arg Val Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu 
        115                 120                 125             


Glu Phe Leu Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp 
    130                 135                 140                 


Arg Ile Asp Ser Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met Leu 
145                 150                 155                 160 


Asp Val Met Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu 
                165                 170                 175     


Leu Phe Gln Asp Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr His 
            180                 185                 190         


Tyr Leu Pro Phe Ser Leu Pro His Arg Arg Pro His Phe Phe Phe Pro 
        195                 200                 205             


Lys Ser Arg Ile Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro 
    210                 215                 220                 


Leu Asn Phe His Ala Met Phe Gln Pro Phe Leu Glu Met Ile His Glu 
225                 230                 235                 240 


Ala Gln Gln Ala Met Asp Ile His Phe His Ser Pro Ala Phe Gln His 
                245                 250                 255     


Pro Pro Thr Glu Phe Ile Arg Glu Gly Asp Asp Asp Arg Thr Val Cys 
            260                 265                 270         


Arg Glu Ile Arg His Asn Ser Thr Gly Cys Leu Arg Met Lys Asp Gln 
        275                 280                 285             


Cys Asp Lys Cys Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn Asn 
    290                 295                 300                 


Pro Ser Gln Ala Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln Val 
305                 310                 315                 320 


Ala Glu Arg Leu Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr Gln 
                325                 330                 335     


Trp Lys Met Leu Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu Gln 
            340                 345                 350         


Phe Asn Trp Val Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp Gln 
        355                 360                 365             


Tyr Tyr Leu Arg Val Thr Thr Val Ala Ser His Thr Ser Asp Ser Asp 
    370                 375                 380                 


Val Pro Ser Gly Val Thr Glu Val Val Val Lys Leu Phe Asp Ser Asp 
385                 390                 395                 400 


Pro Ile Thr Val Thr Val Pro Val Glu Val Ser Arg Lys Asn Pro Lys 
                405                 410                 415     


Phe Met Glu Thr Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys Lys 
            420                 425                 430         


His Arg Glu Glu Leu Asp Asp Asp Asp Lys His His His His His His 
        435                 440                 445             


<210>  15
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  15

Thr Trp Glu Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn 
1               5                   10                  15      


Glu Leu Gln Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu 
            20                  25                  30          


Ile Gln Asn Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu 
        35                  40                  45              


Lys Thr Asn Glu Glu Arg Lys Thr Leu Leu Ser Asn Glu Asp Ala Leu 
    50                  55                  60                  


Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys Glu Leu Pro Gly Val 
65                  70                  75                  80  


Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu Cys Lys Pro Cys Leu 
                85                  90                  95      


Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val Cys Arg Ser Gly Ser 
            100                 105                 110         


Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu Asn Gln Ser Ser Pro 
        115                 120                 125             


Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp Ser Leu Leu Glu Asn 
    130                 135                 140                 


Asp Arg Gln Gln Thr His Met Leu Asp Val Met Gln Asp His Phe Ser 
145                 150                 155                 160 


Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln Asp Arg Phe Phe Thr 
                165                 170                 175     


Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro Phe Ser Leu Pro His 
            180                 185                 190         


Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg Ile Val Arg Ser Leu 
        195                 200                 205             


Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe His Ala Met Phe Gln 
    210                 215                 220                 


Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln Ala Met Asp Ile His 
225                 230                 235                 240 


Phe His Ser Pro Ala Phe Gln His Pro Pro Thr Glu Phe Ile Arg Glu 
                245                 250                 255     


Gly Asp Asp Asp Arg Thr Val Cys Arg Glu Ile Arg His Asn Ser Thr 
            260                 265                 270         


Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys Cys Arg Glu Ile Leu 
        275                 280                 285             


Ser Val Asp Cys Ser Thr Asn Asn Pro Ser Gln Ala Lys Leu Arg Arg 
    290                 295                 300                 


Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg Leu Thr Arg Lys Tyr 
305                 310                 315                 320 


Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met Leu Asn Thr Ser Ser 
                325                 330                 335     


Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp Val Ser Arg Leu Ala 
            340                 345                 350         


Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr Leu Arg Val Thr Thr Val 
        355                 360                 365             


Ala Ser His Thr Ser Asp Ser Asp Val Pro Ser Gly Val Thr Glu Val 
    370                 375                 380                 


Val Val Lys Leu Phe Asp Ser Asp Pro Ile Thr Val Thr Val Pro Val 
385                 390                 395                 400 


Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu Thr Val Ala Glu Lys 
                405                 410                 415     


Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu Glu Leu Asp Asp Asp 
            420                 425                 430         


Asp Lys His His His His His His 
        435                 440 


<210>  16
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease cleavage site

<400>  16

Leu Val Pro Arg Gly Ser 
1               5       


<210>  17
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease cleavage site

<400>  17

Asp Asp Asp Asp Lys 
1               5   


<210>  18
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  18
cacaatatca aggatatcga cgtga                                             25


<210>  19
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  19
acatcagttc tgttcttcgg gtaca                                             25


<210>  20
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  20
ttgtatgtgg acttcagtga tgtg                                              24


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  21
agttcaggtg gtcagcaagg                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  22
tggctatagg atctgggtgc                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  23
atttgctttt gcctgtttgg                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  24
ttacctacac cccgccagtc                                                   20


<210>  25
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  25
tgctggtctg gaagggtcc                                                    19


<210>  26
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  26
gcccttggtg aaggg                                                        15


