                         SEQUENCE LISTING

<110>  MedImmune, LLC
 
<120>  ANTIBODIES TO ADAM17 AND USES THEREOF

<130>  TACE

<150>  GB1421430.8
<151>  2014-12-02

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial sequence of ADAM17/TACE

<400>  1

Asn Glu Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu 
1               5                   10                  15      


Glu Leu Val His Arg Arg Lys Arg Arg Ala Asp Pro Asp Pro Met Lys 
            20                  25                  30          


Asn Thr Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr 
        35                  40                  45              


Met Gly Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu 
    50                  55                  60                  


Ile Asp Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala 
65                  70                  75                  80  


Gly Phe Lys Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys 
                85                  90                  95      


Ser Pro Gln Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys 
            100                 105                 110         


Ser Tyr Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu 
        115                 120                 125             


Glu Gln Phe Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu 
    130                 135                 140                 


Ala His Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu 
145                 150                 155                 160 


Ala Tyr Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro 
                165                 170                 175     


Lys Ala Tyr Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser 
            180                 185                 190         


Gly Leu Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu 
        195                 200                 205             


Ala Asp Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu 
    210                 215                 220                 


His Asp Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly 
225                 230                 235                 240 


Gly Lys Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn 
                245                 250                 255     


Asn Lys Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile 
            260                 265                 270         


Glu Ser Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys 
        275                 280                 285             


Gly Asn 
    290 


<210>  2
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain amino acid sequence of the antibodies 
       designated B07, C06 and HBD-G05

<400>  2

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Pro Phe Gly Gly Met Thr Asp Tyr Ala Thr Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Met Arg Gly Ala Glu Val Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  3
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain amino acid sequence of the antibody 
       designated B07

<400>  3

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Ile Pro Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  4
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain amino acid sequence of the antibodies designated B07,
       C06 and HBD-G05

<400>  4

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Pro Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Pro Phe Gly Gly Met Thr Asp Tyr Ala Thr Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Met Arg Gly Ala Glu Val Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  5
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain amino acid sequence of the antibody designated B07

<400>  5

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Ile Pro Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  6
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain amino acid sequence of the antibody 
       designated 80PH3

<400>  6

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Pro Tyr 
            20                  25                  30          


Pro Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Pro Ser Gly Gly Met Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Met Arg Gly Gly Glu Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  7
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain amino acid sequence of the antibody designated 80PH3

<400>  7

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Pro Tyr 
            20                  25                  30          


Pro Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Pro Ser Gly Gly Met Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Met Arg Gly Gly Glu Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  8
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain amino acid sequence of the antibody 
       designated Combo8TS

<400>  8

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Pro Tyr 
            20                  25                  30          


Pro Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Pro Ser Gly Gly Met Thr Asp Tyr Ala Thr Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Met Arg Gly Ala Glu Val Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  9
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain amino acid sequence of the antibody 
       designated P5W-combo8TS

<400>  9

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Pro Tyr 
            20                  25                  30          


Pro Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Pro Trp Gly Gly Met Thr Asp Tyr Ala Thr Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Met Arg Gly Ala Glu Val Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  10
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain amino acid sequence of the antibodies 
       designated H9M-A08 and HBA-B04

<400>  10

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Pro Tyr 
            20                  25                  30          


Pro Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Pro Phe Gly Gly Met Thr Asp Tyr Ala Thr Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Met Arg Gly Ala Glu Val Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  11
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain amino acid sequence of the antibodies 
       designated 80PH3, Combo8TS and P5W-Combo8TS

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  12
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain amino acid sequence of the antibodies designated 
       80PH3, Combo8TS and P5W-Combo8TS

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  13
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain amino acid sequence of the antibody 
       designated C06

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Trp Thr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Thr Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  14
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain amino acid sequence of the antibody 
       designated HBD-G05

<400>  14

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Trp Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Arg Glu Gln Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  15
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain amino acid sequence of the antibody 
       designated H9M-A08

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Ile Trp Thr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  16
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain amino acid sequence of the antibody 
       designated HBA-B04

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Arg Glu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  17
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding heavy chain variable region of the
       antibody designated 80PH3

<400>  17
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt       60

tcttgcgctg cttccggatt cactttctct ccttacccta tgaattgggt tcgccaagct      120

cctggtaaag gtttggagtg ggtttcttat atctctcctt ctggtggcat gactgattat      180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagagacgct      300

atgagggggg gagagtttga ctactggggc cagggcaccc tggtcaccgt ctcaagc         357


<210>  18
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding heavy chain region of the antibody
       designated 80PH3

<400>  18
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt       60

tcttgcgctg cttccggatt cactttctct ccttacccta tgaattgggt tcgccaagct      120

cctggtaaag gtttggagtg ggtttcttat atctctcctt ctggtggcat gactgattat      180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagagacgct      300

atgagggggg gagagtttga ctactggggc cagggcaccc tggtcaccgt ctcaagcgcg      360

tcgaccaagg gcccatccgt cttccccctg gcaccctcct ccaagagcac ctctgggggc      420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcctgg      480

aactcaggcg ctctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa      660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtc tacaccctgc ccccatcccg ggaggagatg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctatagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagagcttaa gcctgtctcc gggtaaa                                         1347


<210>  19
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding heavy chain variable region of the
       antibodies designated B07, C06 and HBD-G05

<400>  19
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt       60

tcttgcgctg cttccggatt cactttctct tcctacccta tgaattgggt tcgccaagct      120

cctggtaaag gtttggagtg ggtttcttat atctctccct tcggtggcat gactgattat      180

gctacctccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagagacgct      300

atgagggggg cagaggtgga ctactggggc cagggcaccc tggtcaccgt ctcaagc         357


<210>  20
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding heavy chain region of the 
       antibodies designated B07, C06 and HBD-G05

<400>  20
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt       60

tcttgcgctg cttccggatt cactttctct tcctacccta tgaattgggt tcgccaagct      120

cctggtaaag gtttggagtg ggtttcttat atctctccct tcggtggcat gactgattat      180

gctacctccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagagacgct      300

atgagggggg cagaggtgga ctactggggc cagggcaccc tggtcaccgt ctcaagcgcg      360

tcgaccaagg gcccatccgt cttccccctg gcaccctcct ccaagagcac ctctgggggc      420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcctgg      480

aactcaggcg ctctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa      660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtc tacaccctgc ccccatcccg ggaggagatg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctatagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagagcttaa gcctgtctcc gggtaaa                                         1347


<210>  21
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding heavy chain variable region of the
       antibody designated Combo8TS

<400>  21
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt       60

tcttgcgctg cttccggatt cactttctct ccttacccta tgaattgggt tcgccaagct      120

cctggtaaag gtttggagtg ggtttcttat atctctcctt ctggtggcat gactgattat      180

gctacctccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagagacgct      300

atgagggggg cagaggtgga ctactggggc cagggcaccc tggtcaccgt ctcaagc         357


<210>  22
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding heavy chain variable region of the
       antibody designated P5W-Combo8TS

<400>  22
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt       60

tcttgcgctg cttccggatt cactttctct ccttacccta tgaattgggt tcgccaagct      120

cctggtaaag gtttggagtg ggtttcttat atctctcctt ggggtggcat gactgattat      180

gctacctccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagagacgct      300

atgagggggg cagaggtgga ctactggggc cagggcaccc tggtcaccgt ctcaagc         357


<210>  23
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding heavy chain variable region of the
       antibodies designated H9M-A08 and HBA-B04

<400>  23
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt       60

tcttgcgctg cttccggatt cactttctct ccctacccta tgaattgggt tcgccaagct      120

cctggtaaag gtttggagtg ggtttcttat atctctccct tcggtggcat gactgattat      180

gctacctccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagagacgct      300

atgagggggg cagaggtgga ctactggggc cagggcaccc tggtcaccgt ctcaagc         357


<210>  24
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding light chain variable region of the
       antibodies designated 80PH3, Combo8TS and P5W-Combo8TS

<400>  24
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccccctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  25
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding light chain region of the 
       antibodies designated 80PH3, Combo8TS and P5W-Combo8TS

<400>  25
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccccctcac tttcggcgga      300

gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  26
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding light chain variable region of the
       antibody designated B07

<400>  26
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gatccagtca gagcattccc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatcccgtt tacaatccgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccccctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  27
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding light chain region of the antibody
       designated B07

<400>  27
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gatccagtca gagcattccc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatcccgtt tacaatccgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccccctcac tttcggcgga      300

gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  28
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding light chain variable region of the
       antibody designated C06

<400>  28
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gagccagtca gagcatttgg acctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatact gcatcccgtt tacaatccgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccccctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  29
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding light chain variable region of the
       antibody designated HBD-G05

<400>  29
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gagccagtca gagcatttgg agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatcccgtg agcaagaggg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccccctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  30
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding light chain variable region of the
       antibody designated H9M-A08

<400>  30
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gatccagtca gagcatttgg acctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccccctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  31
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding light chain variable region of the
       antibody designated HBA-B04

<400>  31
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatcccgtg agcaatccgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccccctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  32
<211>  824
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino sequence of full-length ADAM17/TACE

<400>  32

Met Arg Gln Ser Leu Leu Phe Leu Thr Ser Val Val Pro Phe Val Leu 
1               5                   10                  15      


Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu 
            20                  25                  30          


Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
        35                  40                  45              


Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr 
    50                  55                  60                  


His Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
65                  70                  75                  80  


Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val 
                85                  90                  95      


Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln 
            100                 105                 110         


Asp Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
        115                 120                 125             


Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly 
    130                 135                 140                 


Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
145                 150                 155                 160 


Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser 
                165                 170                 175     


Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu 
            180                 185                 190         


Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu 
        195                 200                 205             


Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr 
    210                 215                 220                 


Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly 
225                 230                 235                 240 


Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                245                 250                 255     


Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
            260                 265                 270         


Lys Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
        275                 280                 285             


Gln Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr 
    290                 295                 300                 


Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
305                 310                 315                 320 


Phe Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                325                 330                 335     


Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr 
            340                 345                 350         


Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
        355                 360                 365             


Tyr Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
    370                 375                 380                 


Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp 
385                 390                 395                 400 


Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                405                 410                 415     


Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
            420                 425                 430         


Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
        435                 440                 445             


Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser 
    450                 455                 460                 


Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
465                 470                 475                 480 


Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                485                 490                 495     


Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val 
            500                 505                 510         


Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
        515                 520                 525             


Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly 
    530                 535                 540                 


Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn 
545                 550                 555                 560 


Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly 
                565                 570                 575     


Lys Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala 
            580                 585                 590         


Cys Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser 
        595                 600                 605             


Gly Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
    610                 615                 620                 


Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys 
625                 630                 635                 640 


Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                645                 650                 655     


Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile 
            660                 665                 670         


Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
        675                 680                 685             


Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
    690                 695                 700                 


Leu Ser Leu Phe His Pro Ser Asn Val Glu Met Leu Ser Ser Met Asp 
705                 710                 715                 720 


Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro 
                725                 730                 735     


Gly Arg Leu Gln Pro Ala Pro Val Ile Pro Ser Ala Pro Ala Ala Pro 
            740                 745                 750         


Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp Pro Ser Thr 
        755                 760                 765             


Asp Ser His Met Asp Glu Asp Gly Phe Glu Lys Asp Pro Phe Pro Asn 
    770                 775                 780                 


Ser Ser Thr Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp His Pro Val 
785                 790                 795                 800 


Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg Gln Asn Arg 
                805                 810                 815     


Val Asp Ser Lys Glu Thr Glu Cys 
            820                 


<210>  33
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  33

Ser Tyr Pro Met Asn 
1               5   


<210>  34
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  34

Tyr Ile Ser Pro Phe Gly Gly Met Thr Asp Tyr Ala Thr Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  35

Asp Ala Met Arg Gly Ala Glu Val Asp Tyr 
1               5                   10  


<210>  36
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  36

Arg Ser Ser Gln Ser Ile Pro Ser Tyr Leu Asn 
1               5                   10      


<210>  37
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  37

Ala Ala Ser Arg Leu Gln Ser 
1               5           


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  38

Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  39
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  39

Pro Tyr Pro Met Asn 
1               5   


<210>  40
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  40

Tyr Ile Ser Pro Ser Gly Gly Met Thr Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  41
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  41

Asp Ala Met Arg Gly Gly Glu Phe Asp Tyr 
1               5                   10  


<210>  42
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  42

Tyr Ile Ser Pro Ser Gly Gly Met Thr Asp Tyr Ala Thr Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  43
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  43

Tyr Ile Ser Pro Trp Gly Gly Met Thr Asp Tyr Ala Thr Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  44
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  44

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  45

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  46
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  46

Arg Ala Ser Gln Ser Ile Trp Thr Tyr Leu Asn 
1               5                   10      


<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  47

Thr Ala Ser Arg Leu Gln Ser 
1               5           


<210>  48
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  48

Arg Ala Ser Gln Ser Ile Trp Ser Tyr Leu Asn 
1               5                   10      


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  49

Ala Ala Ser Arg Glu Gln Glu 
1               5           


<210>  50
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  50

Arg Ser Ser Gln Ser Ile Trp Thr Tyr Leu Asn 
1               5                   10      


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  51

Ala Ala Ser Arg Glu Gln Ser 
1               5           
