                               SEQUENCE LISTING

<110> SUMMA HEALTH
 
<120> CAMKK1 AS A NOVEL REGENERATIVE THERAPEUTIC

<130> 101521.000119

<140> PCT/US2015/063118
<141> 2015-12-01

<150> 62/086,026
<151> 2014-12-01

<160> 17    

<170> PatentIn version 3.5

<210> 1
<211> 1518
<212> DNA
<213> Homo sapiens

<400> 1
atggaggggg gtccagctgt ctgctgccag gatcctcggg cagagctggt agaacgggtg       60

gcagccatcg atgtgactca cttggaggag gcagatggtg gcccagagcc tactagaaac      120

ggtgtggacc ccccaccacg ggccagagct gcctctgtga tccctggcag tacttcaaga      180

ctgctcccag cccggcctag cctctcagcc aggaagcttt ccctacagga gcggccagca      240

ggaagctatc tggaggcgca ggctgggcct tatgccacgg ggcctgccag ccacatctcc      300

ccccgggcct ggcggaggcc caccatcgag tcccaccacg tggccatctc agatgcagag      360

gactgcgtgc agctgaacca gtacaagctg cagagtgaga ttggcaaggg tgcctacggt      420

gtggtgaggc tggcctacaa cgaaagtgaa gacagacact atgcaatgaa agtcctttcc      480

aaaaagaagt tactgaagca gtatggcttt ccacgtcgcc ctcccccgag agggtcccag      540

gctgcccagg gaggaccagc caagcagctg ctgcccctgg agcgggtgta ccaggagatt      600

gccatcctga agaagctgga ccacgtgaat gtggtcaaac tgatcgaggt cctggatgac      660

ccagctgagg acaacctcta tttggtgttt gacctcctga gaaaggggcc cgtcatggaa      720

gtgccctgtg acaagccctt ctcggaggag caagctcgcc tctacctgcg ggacgtcatc      780

ctgggcctcg agtacttgca ctgccagaag atcgtccaca gggacatcaa gccatccaac      840

ctgctcctgg gggatgatgg gcacgtgaag atcgccgact ttggcgtcag caaccagttt      900

gaggggaacg acgctcagct gtccagcacg gcgggaaccc cagcattcat ggcccccgag      960

gccatttctg attccggcca gagcttcagt gggaaggcct tggatgtatg ggccactggc     1020

gtcacgttgt actgctttgt ctatgggaag tgcccattca tcgacgattt catcctggcc     1080

ctccacagga agatcaagaa tgagcccgtg gtgtttcctg aggagccaga aatcagcgag     1140

gagctcaagg acctgatcct gaagatgtta gacaagaatc ccgagacgag aattggggtg     1200

ccagacatca agttgcaccc ttgggtgacc aagaacgggg aggagcccct tccttcggag     1260

gaggagcact gcagcgtggt ggaggtgaca gaggaggagg ttaagaactc agtcaggctc     1320

atccccagct ggaccacggt gatcctggtg aagtccatgc tgaggaagcg ttcctttggg     1380

aacccgtttg agccccaagc acggagggaa gagcgatcca tgtctgctcc aggaaaccta     1440

ctggtgaaag aagggtttgg tgaagggggc aagagcccag agctccccgg cgtccaggaa     1500

gacgaggctg catcctga                                                   1518


<210> 2
<211> 505
<212> PRT
<213> Homo sapiens

<400> 2
Met Glu Gly Gly Pro Ala Val Cys Cys Gln Asp Pro Arg Ala Glu Leu 
1               5                   10                  15      


Val Glu Arg Val Ala Ala Ile Asp Val Thr His Leu Glu Glu Ala Asp 
            20                  25                  30          


Gly Gly Pro Glu Pro Thr Arg Asn Gly Val Asp Pro Pro Pro Arg Ala 
        35                  40                  45              


Arg Ala Ala Ser Val Ile Pro Gly Ser Thr Ser Arg Leu Leu Pro Ala 
    50                  55                  60                  


Arg Pro Ser Leu Ser Ala Arg Lys Leu Ser Leu Gln Glu Arg Pro Ala 
65                  70                  75                  80  


Gly Ser Tyr Leu Glu Ala Gln Ala Gly Pro Tyr Ala Thr Gly Pro Ala 
                85                  90                  95      


Ser His Ile Ser Pro Arg Ala Trp Arg Arg Pro Thr Ile Glu Ser His 
            100                 105                 110         


His Val Ala Ile Ser Asp Ala Glu Asp Cys Val Gln Leu Asn Gln Tyr 
        115                 120                 125             


Lys Leu Gln Ser Glu Ile Gly Lys Gly Ala Tyr Gly Val Val Arg Leu 
    130                 135                 140                 


Ala Tyr Asn Glu Ser Glu Asp Arg His Tyr Ala Met Lys Val Leu Ser 
145                 150                 155                 160 


Lys Lys Lys Leu Leu Lys Gln Tyr Gly Phe Pro Arg Arg Pro Pro Pro 
                165                 170                 175     


Arg Gly Ser Gln Ala Ala Gln Gly Gly Pro Ala Lys Gln Leu Leu Pro 
            180                 185                 190         


Leu Glu Arg Val Tyr Gln Glu Ile Ala Ile Leu Lys Lys Leu Asp His 
        195                 200                 205             


Val Asn Val Val Lys Leu Ile Glu Val Leu Asp Asp Pro Ala Glu Asp 
    210                 215                 220                 


Asn Leu Tyr Leu Val Phe Asp Leu Leu Arg Lys Gly Pro Val Met Glu 
225                 230                 235                 240 


Val Pro Cys Asp Lys Pro Phe Ser Glu Glu Gln Ala Arg Leu Tyr Leu 
                245                 250                 255     


Arg Asp Val Ile Leu Gly Leu Glu Tyr Leu His Cys Gln Lys Ile Val 
            260                 265                 270         


His Arg Asp Ile Lys Pro Ser Asn Leu Leu Leu Gly Asp Asp Gly His 
        275                 280                 285             


Val Lys Ile Ala Asp Phe Gly Val Ser Asn Gln Phe Glu Gly Asn Asp 
    290                 295                 300                 


Ala Gln Leu Ser Ser Thr Ala Gly Thr Pro Ala Phe Met Ala Pro Glu 
305                 310                 315                 320 


Ala Ile Ser Asp Ser Gly Gln Ser Phe Ser Gly Lys Ala Leu Asp Val 
                325                 330                 335     


Trp Ala Thr Gly Val Thr Leu Tyr Cys Phe Val Tyr Gly Lys Cys Pro 
            340                 345                 350         


Phe Ile Asp Asp Phe Ile Leu Ala Leu His Arg Lys Ile Lys Asn Glu 
        355                 360                 365             


Pro Val Val Phe Pro Glu Glu Pro Glu Ile Ser Glu Glu Leu Lys Asp 
    370                 375                 380                 


Leu Ile Leu Lys Met Leu Asp Lys Asn Pro Glu Thr Arg Ile Gly Val 
385                 390                 395                 400 


Pro Asp Ile Lys Leu His Pro Trp Val Thr Lys Asn Gly Glu Glu Pro 
                405                 410                 415     


Leu Pro Ser Glu Glu Glu His Cys Ser Val Val Glu Val Thr Glu Glu 
            420                 425                 430         


Glu Val Lys Asn Ser Val Arg Leu Ile Pro Ser Trp Thr Thr Val Ile 
        435                 440                 445             


Leu Val Lys Ser Met Leu Arg Lys Arg Ser Phe Gly Asn Pro Phe Glu 
    450                 455                 460                 


Pro Gln Ala Arg Arg Glu Glu Arg Ser Met Ser Ala Pro Gly Asn Leu 
465                 470                 475                 480 


Leu Val Lys Glu Gly Phe Gly Glu Gly Gly Lys Ser Pro Glu Leu Pro 
                485                 490                 495     


Gly Val Gln Glu Asp Glu Ala Ala Ser 
            500                 505 


<210> 3
<211> 1242
<212> DNA
<213> Homo sapiens

<400> 3
atggaggggg gtccagctgt ctgctgccag gatcctcggg cagagctggt agaacgggtg       60

gcagccatcg atgtgactca cttggaggag gcagatggtg gcccagagcc tactagaaac      120

ggtgtggacc ccccaccacg ggccagagct gcctctgtga tccctggcag tacttcaaga      180

ctgctcccag cccggcctag cctctcagcc aggaagcttt ccctacagga gcggccagca      240

ggaagctatc tggaggcgca ggctgggcct tatgccacgg ggcctgccag ccacatctcc      300

ccccgggcct ggcggaggcc caccatcgag tcccaccacg tggccatctc agatgcagag      360

gactgcgtgc agctgaacca gtacaagctg cagagtgaga ttggcaaggg tgcctacggt      420

gtggtgaggc tggcctacaa cgaaagtgaa gacagacact atgcaatgaa agtcctttcc      480

aaaaagaagt tactgaagca gtatggcttt ccacgtcgcc ctcccccgag agggtcccag      540

gctgcccagg gaggaccagc caagcagctg ctgcccctgg agcgggtgta ccaggagatt      600

gccatcctga agaagctgga ccacgtgaat gtggtcaaac tgatcgaggt cctggatgac      660

ccagctgagg acaacctcta tttggtgttt gacctcctga gaaaggggcc cgtcatggaa      720

gtgccctgtg acaagccctt ctcggaggag caagctcgcc tctacctgcg ggacgtcatc      780

ctgggcctcg agtacttgca ctgccagaag atcgtccaca gggacatcaa gccatccaac      840

ctgctcctgg gggatgatgg gcacgtgaag atcgccgact ttggcgtcag caaccagttt      900

gaggggaacg acgctcagct gtccagcacg gcgggaaccc cagcattcat ggcccccgag      960

gccatttctg attccggcca gagcttcagt gggaaggcct tggatgtatg ggccactggc     1020

gtcacgttgt actgctttgt ctatgggaag tgcccattca tcgacgattt catcctggcc     1080

ctccacagga agatcaagaa tgagcccgtg gtgtttcctg aggagccaga aatcagcgag     1140

gagctcaagg acctgatcct gaagatgtta gacaagaatc ccgagacgag aattggggtg     1200

ccagacatca agttgcaccc ttgggtgacc aagaacgggt ga                        1242


<210> 4
<211> 413
<212> PRT
<213> Homo sapiens

<400> 4
Met Glu Gly Gly Pro Ala Val Cys Cys Gln Asp Pro Arg Ala Glu Leu 
1               5                   10                  15      


Val Glu Arg Val Ala Ala Ile Asp Val Thr His Leu Glu Glu Ala Asp 
            20                  25                  30          


Gly Gly Pro Glu Pro Thr Arg Asn Gly Val Asp Pro Pro Pro Arg Ala 
        35                  40                  45              


Arg Ala Ala Ser Val Ile Pro Gly Ser Thr Ser Arg Leu Leu Pro Ala 
    50                  55                  60                  


Arg Pro Ser Leu Ser Ala Arg Lys Leu Ser Leu Gln Glu Arg Pro Ala 
65                  70                  75                  80  


Gly Ser Tyr Leu Glu Ala Gln Ala Gly Pro Tyr Ala Thr Gly Pro Ala 
                85                  90                  95      


Ser His Ile Ser Pro Arg Ala Trp Arg Arg Pro Thr Ile Glu Ser His 
            100                 105                 110         


His Val Ala Ile Ser Asp Ala Glu Asp Cys Val Gln Leu Asn Gln Tyr 
        115                 120                 125             


Lys Leu Gln Ser Glu Ile Gly Lys Gly Ala Tyr Gly Val Val Arg Leu 
    130                 135                 140                 


Ala Tyr Asn Glu Ser Glu Asp Arg His Tyr Ala Met Lys Val Leu Ser 
145                 150                 155                 160 


Lys Lys Lys Leu Leu Lys Gln Tyr Gly Phe Pro Arg Arg Pro Pro Pro 
                165                 170                 175     


Arg Gly Ser Gln Ala Ala Gln Gly Gly Pro Ala Lys Gln Leu Leu Pro 
            180                 185                 190         


Leu Glu Arg Val Tyr Gln Glu Ile Ala Ile Leu Lys Lys Leu Asp His 
        195                 200                 205             


Val Asn Val Val Lys Leu Ile Glu Val Leu Asp Asp Pro Ala Glu Asp 
    210                 215                 220                 


Asn Leu Tyr Leu Val Phe Asp Leu Leu Arg Lys Gly Pro Val Met Glu 
225                 230                 235                 240 


Val Pro Cys Asp Lys Pro Phe Ser Glu Glu Gln Ala Arg Leu Tyr Leu 
                245                 250                 255     


Arg Asp Val Ile Leu Gly Leu Glu Tyr Leu His Cys Gln Lys Ile Val 
            260                 265                 270         


His Arg Asp Ile Lys Pro Ser Asn Leu Leu Leu Gly Asp Asp Gly His 
        275                 280                 285             


Val Lys Ile Ala Asp Phe Gly Val Ser Asn Gln Phe Glu Gly Asn Asp 
    290                 295                 300                 


Ala Gln Leu Ser Ser Thr Ala Gly Thr Pro Ala Phe Met Ala Pro Glu 
305                 310                 315                 320 


Ala Ile Ser Asp Ser Gly Gln Ser Phe Ser Gly Lys Ala Leu Asp Val 
                325                 330                 335     


Trp Ala Thr Gly Val Thr Leu Tyr Cys Phe Val Tyr Gly Lys Cys Pro 
            340                 345                 350         


Phe Ile Asp Asp Phe Ile Leu Ala Leu His Arg Lys Ile Lys Asn Glu 
        355                 360                 365             


Pro Val Val Phe Pro Glu Glu Pro Glu Ile Ser Glu Glu Leu Lys Asp 
    370                 375                 380                 


Leu Ile Leu Lys Met Leu Asp Lys Asn Pro Glu Thr Arg Ile Gly Val 
385                 390                 395                 400 


Pro Asp Ile Lys Leu His Pro Trp Val Thr Lys Asn Gly 
                405                 410             


<210> 5
<211> 1518
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
atggaggggg gtccagctgt ctgctgccag gatcctcggg cagagctggt agaacgggtg       60

gcagccatcg atgtgactca cttggaggag gcagatggtg gcccagagcc tactagaaac      120

ggtgtggacc ccccaccacg ggccagagct gcctctgtga tccctggcag tacttcaaga      180

ctgctcccag cccggcctag cctctcagcc aggaagcttt ccctacagga gcggccagca      240

ggaagctatc tggaggcgca ggctgggcct tatgccacgg ggcctgccag ccacatctcc      300

ccccgggcct ggcggaggcc cgacatcgag tcccaccacg tggccatctc agatgcagag      360

gactgcgtgc agctgaacca gtacaagctg cagagtgaga ttggcaaggg tgcctacggt      420

gtggtgaggc tggcctacaa cgaaagtgaa gacagacact atgcaatgaa agtcctttcc      480

aaaaagaagt tactgaagca gtatggcttt ccacgtcgcc ctcccccgag agggtcccag      540

gctgcccagg gaggaccagc caagcagctg ctgcccctgg agcgggtgta ccaggagatt      600

gccatcctga agaagctgga ccacgtgaat gtggtcaaac tgatcgaggt cctggatgac      660

ccagctgagg acaacctcta tttggtgttt gacctcctga gaaaggggcc cgtcatggaa      720

gtgccctgtg acaagccctt ctcggaggag caagctcgcc tctacctgcg ggacgtcatc      780

ctgggcctcg agtacttgca ctgccagaag atcgtccaca gggacatcaa gccatccaac      840

ctgctcctgg gggatgatgg gcacgtgaag atcgccgact ttggcgtcag caaccagttt      900

gaggggaacg acgctcagct gtccagcacg gcgggaaccc cagcattcat ggcccccgag      960

gccatttctg attccggcca gagcttcagt gggaaggcct tggatgtatg ggccactggc     1020

gtcacgttgt actgctttgt ctatgggaag tgcccattca tcgacgattt catcctggcc     1080

ctccacagga agatcaagaa tgagcccgtg gtgtttcctg aggagccaga aatcagcgag     1140

gagctcaagg acctgatcct gaagatgtta gacaagaatc ccgagacgag aattggggtg     1200

ccagacatca agttgcaccc ttgggtgacc aagaacgggg aggagcccct tccttcggag     1260

gaggagcact gcagcgtggt ggaggtgaca gaggaggagg ttaagaactc agtcaggctc     1320

atccccagct ggaccacggt gatcctggtg aagtccatgc tgaggaagcg ttcctttggg     1380

aacccgtttg agccccaagc acggagggaa gagcgatcca tgtctgctcc aggaaaccta     1440

ctggtgaaag aagggtttgg tgaagggggc aagagcccag agctccccgg cgtccaggaa     1500

gacgaggctg catcctga                                                   1518


<210> 6
<211> 505
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Met Glu Gly Gly Pro Ala Val Cys Cys Gln Asp Pro Arg Ala Glu Leu 
1               5                   10                  15      


Val Glu Arg Val Ala Ala Ile Asp Val Thr His Leu Glu Glu Ala Asp 
            20                  25                  30          


Gly Gly Pro Glu Pro Thr Arg Asn Gly Val Asp Pro Pro Pro Arg Ala 
        35                  40                  45              


Arg Ala Ala Ser Val Ile Pro Gly Ser Thr Ser Arg Leu Leu Pro Ala 
    50                  55                  60                  


Arg Pro Ser Leu Ser Ala Arg Lys Leu Ser Leu Gln Glu Arg Pro Ala 
65                  70                  75                  80  


Gly Ser Tyr Leu Glu Ala Gln Ala Gly Pro Tyr Ala Thr Gly Pro Ala 
                85                  90                  95      


Ser His Ile Ser Pro Arg Ala Trp Arg Arg Pro Asp Ile Glu Ser His 
            100                 105                 110         


His Val Ala Ile Ser Asp Ala Glu Asp Cys Val Gln Leu Asn Gln Tyr 
        115                 120                 125             


Lys Leu Gln Ser Glu Ile Gly Lys Gly Ala Tyr Gly Val Val Arg Leu 
    130                 135                 140                 


Ala Tyr Asn Glu Ser Glu Asp Arg His Tyr Ala Met Lys Val Leu Ser 
145                 150                 155                 160 


Lys Lys Lys Leu Leu Lys Gln Tyr Gly Phe Pro Arg Arg Pro Pro Pro 
                165                 170                 175     


Arg Gly Ser Gln Ala Ala Gln Gly Gly Pro Ala Lys Gln Leu Leu Pro 
            180                 185                 190         


Leu Glu Arg Val Tyr Gln Glu Ile Ala Ile Leu Lys Lys Leu Asp His 
        195                 200                 205             


Val Asn Val Val Lys Leu Ile Glu Val Leu Asp Asp Pro Ala Glu Asp 
    210                 215                 220                 


Asn Leu Tyr Leu Val Phe Asp Leu Leu Arg Lys Gly Pro Val Met Glu 
225                 230                 235                 240 


Val Pro Cys Asp Lys Pro Phe Ser Glu Glu Gln Ala Arg Leu Tyr Leu 
                245                 250                 255     


Arg Asp Val Ile Leu Gly Leu Glu Tyr Leu His Cys Gln Lys Ile Val 
            260                 265                 270         


His Arg Asp Ile Lys Pro Ser Asn Leu Leu Leu Gly Asp Asp Gly His 
        275                 280                 285             


Val Lys Ile Ala Asp Phe Gly Val Ser Asn Gln Phe Glu Gly Asn Asp 
    290                 295                 300                 


Ala Gln Leu Ser Ser Thr Ala Gly Thr Pro Ala Phe Met Ala Pro Glu 
305                 310                 315                 320 


Ala Ile Ser Asp Ser Gly Gln Ser Phe Ser Gly Lys Ala Leu Asp Val 
                325                 330                 335     


Trp Ala Thr Gly Val Thr Leu Tyr Cys Phe Val Tyr Gly Lys Cys Pro 
            340                 345                 350         


Phe Ile Asp Asp Phe Ile Leu Ala Leu His Arg Lys Ile Lys Asn Glu 
        355                 360                 365             


Pro Val Val Phe Pro Glu Glu Pro Glu Ile Ser Glu Glu Leu Lys Asp 
    370                 375                 380                 


Leu Ile Leu Lys Met Leu Asp Lys Asn Pro Glu Thr Arg Ile Gly Val 
385                 390                 395                 400 


Pro Asp Ile Lys Leu His Pro Trp Val Thr Lys Asn Gly Glu Glu Pro 
                405                 410                 415     


Leu Pro Ser Glu Glu Glu His Cys Ser Val Val Glu Val Thr Glu Glu 
            420                 425                 430         


Glu Val Lys Asn Ser Val Arg Leu Ile Pro Ser Trp Thr Thr Val Ile 
        435                 440                 445             


Leu Val Lys Ser Met Leu Arg Lys Arg Ser Phe Gly Asn Pro Phe Glu 
    450                 455                 460                 


Pro Gln Ala Arg Arg Glu Glu Arg Ser Met Ser Ala Pro Gly Asn Leu 
465                 470                 475                 480 


Leu Val Lys Glu Gly Phe Gly Glu Gly Gly Lys Ser Pro Glu Leu Pro 
                485                 490                 495     


Gly Val Gln Glu Asp Glu Ala Ala Ser 
            500                 505 


<210> 7
<211> 1518
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
atggaggggg gtccagctgt ctgctgccag gatcctcggg cagagctggt agaacgggtg       60

gcagccatcg atgtgactca cttggaggag gcagatggtg gcccagagcc tactagaaac      120

ggtgtggacc ccccaccacg ggccagagct gcctctgtga tccctggcag tacttcaaga      180

ctgctcccag cccggcctag cctctcagcc aggaagcttt ccctacagga gcggccagca      240

ggaagctatc tggaggcgca ggctgggcct tatgccacgg ggcctgccag ccacatctcc      300

ccccgggcct ggcggaggcc caccatcgag tcccaccacg tggccatctc agatgcagag      360

gactgcgtgc agctgaacca gtacaagctg cagagtgaga ttggcaaggg tgcctacggt      420

gtggtgaggc tggcctacaa cgaaagtgaa gacagacact atgcaatgaa agtcctttcc      480

aaaaagaagt tactgaagca gtatggcttt ccacgtcgcc ctcccccgag agggtcccag      540

gctgcccagg gaggaccagc caagcagctg ctgcccctgg agcgggtgta ccaggagatt      600

gccatcctga agaagctgga ccacgtgaat gtggtcaaac tgatcgaggt cctggatgac      660

ccagctgagg acaacctcta tttggtgttt gacctcctga gaaaggggcc cgtcatggaa      720

gtgccctgtg acaagccctt ctcggaggag caagctcgcc tctacctgcg ggacgtcatc      780

ctgggcctcg agtacttgca ctgccagaag atcgtccaca gggacatcaa gccatccaac      840

ctgctcctgg gggatgatgg gcacgtgaag atcgccgact ttggcgtcag caaccagttt      900

gaggggaacg acgctcagct gtccagcacg gcgggaaccc cagcattcat ggcccccgag      960

gccatttctg attccggcca gagcttcagt gggaaggcct tggatgtatg ggccactggc     1020

gtcacgttgt actgctttgt ctatgggaag tgcccattca tcgacgattt catcctggcc     1080

ctccacagga agatcaagaa tgagcccgtg gtgtttcctg aggagccaga aatcagcgag     1140

gagctcaagg acctgatcct gaagatgtta gacaagaatc ccgagacgag aattggggtg     1200

ccagacatca agttgcaccc ttgggtgacc aagaacgggg aggagcccct tccttcggag     1260

gaggagcact gcagcgtggt ggaggtgaca gaggaggagg ttaagaactc agtcaggctc     1320

atccccagct ggaccacggt gatcctggtg aagtccatgc tgaggaagcg tgactttggg     1380

aacccgtttg agccccaagc acggagggaa gagcgatcca tgtctgctcc aggaaaccta     1440

ctggtgaaag aagggtttgg tgaagggggc aagagcccag agctccccgg cgtccaggaa     1500

gacgaggctg catcctga                                                   1518


<210> 8
<211> 505
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Met Glu Gly Gly Pro Ala Val Cys Cys Gln Asp Pro Arg Ala Glu Leu 
1               5                   10                  15      


Val Glu Arg Val Ala Ala Ile Asp Val Thr His Leu Glu Glu Ala Asp 
            20                  25                  30          


Gly Gly Pro Glu Pro Thr Arg Asn Gly Val Asp Pro Pro Pro Arg Ala 
        35                  40                  45              


Arg Ala Ala Ser Val Ile Pro Gly Ser Thr Ser Arg Leu Leu Pro Ala 
    50                  55                  60                  


Arg Pro Ser Leu Ser Ala Arg Lys Leu Ser Leu Gln Glu Arg Pro Ala 
65                  70                  75                  80  


Gly Ser Tyr Leu Glu Ala Gln Ala Gly Pro Tyr Ala Thr Gly Pro Ala 
                85                  90                  95      


Ser His Ile Ser Pro Arg Ala Trp Arg Arg Pro Thr Ile Glu Ser His 
            100                 105                 110         


His Val Ala Ile Ser Asp Ala Glu Asp Cys Val Gln Leu Asn Gln Tyr 
        115                 120                 125             


Lys Leu Gln Ser Glu Ile Gly Lys Gly Ala Tyr Gly Val Val Arg Leu 
    130                 135                 140                 


Ala Tyr Asn Glu Ser Glu Asp Arg His Tyr Ala Met Lys Val Leu Ser 
145                 150                 155                 160 


Lys Lys Lys Leu Leu Lys Gln Tyr Gly Phe Pro Arg Arg Pro Pro Pro 
                165                 170                 175     


Arg Gly Ser Gln Ala Ala Gln Gly Gly Pro Ala Lys Gln Leu Leu Pro 
            180                 185                 190         


Leu Glu Arg Val Tyr Gln Glu Ile Ala Ile Leu Lys Lys Leu Asp His 
        195                 200                 205             


Val Asn Val Val Lys Leu Ile Glu Val Leu Asp Asp Pro Ala Glu Asp 
    210                 215                 220                 


Asn Leu Tyr Leu Val Phe Asp Leu Leu Arg Lys Gly Pro Val Met Glu 
225                 230                 235                 240 


Val Pro Cys Asp Lys Pro Phe Ser Glu Glu Gln Ala Arg Leu Tyr Leu 
                245                 250                 255     


Arg Asp Val Ile Leu Gly Leu Glu Tyr Leu His Cys Gln Lys Ile Val 
            260                 265                 270         


His Arg Asp Ile Lys Pro Ser Asn Leu Leu Leu Gly Asp Asp Gly His 
        275                 280                 285             


Val Lys Ile Ala Asp Phe Gly Val Ser Asn Gln Phe Glu Gly Asn Asp 
    290                 295                 300                 


Ala Gln Leu Ser Ser Thr Ala Gly Thr Pro Ala Phe Met Ala Pro Glu 
305                 310                 315                 320 


Ala Ile Ser Asp Ser Gly Gln Ser Phe Ser Gly Lys Ala Leu Asp Val 
                325                 330                 335     


Trp Ala Thr Gly Val Thr Leu Tyr Cys Phe Val Tyr Gly Lys Cys Pro 
            340                 345                 350         


Phe Ile Asp Asp Phe Ile Leu Ala Leu His Arg Lys Ile Lys Asn Glu 
        355                 360                 365             


Pro Val Val Phe Pro Glu Glu Pro Glu Ile Ser Glu Glu Leu Lys Asp 
    370                 375                 380                 


Leu Ile Leu Lys Met Leu Asp Lys Asn Pro Glu Thr Arg Ile Gly Val 
385                 390                 395                 400 


Pro Asp Ile Lys Leu His Pro Trp Val Thr Lys Asn Gly Glu Glu Pro 
                405                 410                 415     


Leu Pro Ser Glu Glu Glu His Cys Ser Val Val Glu Val Thr Glu Glu 
            420                 425                 430         


Glu Val Lys Asn Ser Val Arg Leu Ile Pro Ser Trp Thr Thr Val Ile 
        435                 440                 445             


Leu Val Lys Ser Met Leu Arg Lys Arg Asp Phe Gly Asn Pro Phe Glu 
    450                 455                 460                 


Pro Gln Ala Arg Arg Glu Glu Arg Ser Met Ser Ala Pro Gly Asn Leu 
465                 470                 475                 480 


Leu Val Lys Glu Gly Phe Gly Glu Gly Gly Lys Ser Pro Glu Leu Pro 
                485                 490                 495     


Gly Val Gln Glu Asp Glu Ala Ala Ser 
            500                 505 


<210> 9
<211> 1518
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 9
atggaggggg gtccagctgt ctgctgccag gatcctcggg cagagctggt agaacgggtg       60

gcagccatcg atgtgactca cttggaggag gcagatggtg gcccagagcc tactagaaac      120

ggtgtggacc ccccaccacg ggccagagct gcctctgtga tccctggcag tacttcaaga      180

ctgctcccag cccggcctag cctctcagcc aggaagcttt ccctacagga gcggccagca      240

ggaagctatc tggaggcgca ggctgggcct tatgccacgg ggcctgccag ccacatctcc      300

ccccgggcct ggcggaggcc cgacatcgag tcccaccacg tggccatctc agatgcagag      360

gactgcgtgc agctgaacca gtacaagctg cagagtgaga ttggcaaggg tgcctacggt      420

gtggtgaggc tggcctacaa cgaaagtgaa gacagacact atgcaatgaa agtcctttcc      480

aaaaagaagt tactgaagca gtatggcttt ccacgtcgcc ctcccccgag agggtcccag      540

gctgcccagg gaggaccagc caagcagctg ctgcccctgg agcgggtgta ccaggagatt      600

gccatcctga agaagctgga ccacgtgaat gtggtcaaac tgatcgaggt cctggatgac      660

ccagctgagg acaacctcta tttggtgttt gacctcctga gaaaggggcc cgtcatggaa      720

gtgccctgtg acaagccctt ctcggaggag caagctcgcc tctacctgcg ggacgtcatc      780

ctgggcctcg agtacttgca ctgccagaag atcgtccaca gggacatcaa gccatccaac      840

ctgctcctgg gggatgatgg gcacgtgaag atcgccgact ttggcgtcag caaccagttt      900

gaggggaacg acgctcagct gtccagcacg gcgggaaccc cagcattcat ggcccccgag      960

gccatttctg attccggcca gagcttcagt gggaaggcct tggatgtatg ggccactggc     1020

gtcacgttgt actgctttgt ctatgggaag tgcccattca tcgacgattt catcctggcc     1080

ctccacagga agatcaagaa tgagcccgtg gtgtttcctg aggagccaga aatcagcgag     1140

gagctcaagg acctgatcct gaagatgtta gacaagaatc ccgagacgag aattggggtg     1200

ccagacatca agttgcaccc ttgggtgacc aagaacgggg aggagcccct tccttcggag     1260

gaggagcact gcagcgtggt ggaggtgaca gaggaggagg ttaagaactc agtcaggctc     1320

atccccagct ggaccacggt gatcctggtg aagtccatgc tgaggaagcg tgactttggg     1380

aacccgtttg agccccaagc acggagggaa gagcgatcca tgtctgctcc aggaaaccta     1440

ctggtgaaag aagggtttgg tgaagggggc aagagcccag agctccccgg cgtccaggaa     1500

gacgaggctg catcctga                                                   1518


<210> 10
<211> 505
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Met Glu Gly Gly Pro Ala Val Cys Cys Gln Asp Pro Arg Ala Glu Leu 
1               5                   10                  15      


Val Glu Arg Val Ala Ala Ile Asp Val Thr His Leu Glu Glu Ala Asp 
            20                  25                  30          


Gly Gly Pro Glu Pro Thr Arg Asn Gly Val Asp Pro Pro Pro Arg Ala 
        35                  40                  45              


Arg Ala Ala Ser Val Ile Pro Gly Ser Thr Ser Arg Leu Leu Pro Ala 
    50                  55                  60                  


Arg Pro Ser Leu Ser Ala Arg Lys Leu Ser Leu Gln Glu Arg Pro Ala 
65                  70                  75                  80  


Gly Ser Tyr Leu Glu Ala Gln Ala Gly Pro Tyr Ala Thr Gly Pro Ala 
                85                  90                  95      


Ser His Ile Ser Pro Arg Ala Trp Arg Arg Pro Asp Ile Glu Ser His 
            100                 105                 110         


His Val Ala Ile Ser Asp Ala Glu Asp Cys Val Gln Leu Asn Gln Tyr 
        115                 120                 125             


Lys Leu Gln Ser Glu Ile Gly Lys Gly Ala Tyr Gly Val Val Arg Leu 
    130                 135                 140                 


Ala Tyr Asn Glu Ser Glu Asp Arg His Tyr Ala Met Lys Val Leu Ser 
145                 150                 155                 160 


Lys Lys Lys Leu Leu Lys Gln Tyr Gly Phe Pro Arg Arg Pro Pro Pro 
                165                 170                 175     


Arg Gly Ser Gln Ala Ala Gln Gly Gly Pro Ala Lys Gln Leu Leu Pro 
            180                 185                 190         


Leu Glu Arg Val Tyr Gln Glu Ile Ala Ile Leu Lys Lys Leu Asp His 
        195                 200                 205             


Val Asn Val Val Lys Leu Ile Glu Val Leu Asp Asp Pro Ala Glu Asp 
    210                 215                 220                 


Asn Leu Tyr Leu Val Phe Asp Leu Leu Arg Lys Gly Pro Val Met Glu 
225                 230                 235                 240 


Val Pro Cys Asp Lys Pro Phe Ser Glu Glu Gln Ala Arg Leu Tyr Leu 
                245                 250                 255     


Arg Asp Val Ile Leu Gly Leu Glu Tyr Leu His Cys Gln Lys Ile Val 
            260                 265                 270         


His Arg Asp Ile Lys Pro Ser Asn Leu Leu Leu Gly Asp Asp Gly His 
        275                 280                 285             


Val Lys Ile Ala Asp Phe Gly Val Ser Asn Gln Phe Glu Gly Asn Asp 
    290                 295                 300                 


Ala Gln Leu Ser Ser Thr Ala Gly Thr Pro Ala Phe Met Ala Pro Glu 
305                 310                 315                 320 


Ala Ile Ser Asp Ser Gly Gln Ser Phe Ser Gly Lys Ala Leu Asp Val 
                325                 330                 335     


Trp Ala Thr Gly Val Thr Leu Tyr Cys Phe Val Tyr Gly Lys Cys Pro 
            340                 345                 350         


Phe Ile Asp Asp Phe Ile Leu Ala Leu His Arg Lys Ile Lys Asn Glu 
        355                 360                 365             


Pro Val Val Phe Pro Glu Glu Pro Glu Ile Ser Glu Glu Leu Lys Asp 
    370                 375                 380                 


Leu Ile Leu Lys Met Leu Asp Lys Asn Pro Glu Thr Arg Ile Gly Val 
385                 390                 395                 400 


Pro Asp Ile Lys Leu His Pro Trp Val Thr Lys Asn Gly Glu Glu Pro 
                405                 410                 415     


Leu Pro Ser Glu Glu Glu His Cys Ser Val Val Glu Val Thr Glu Glu 
            420                 425                 430         


Glu Val Lys Asn Ser Val Arg Leu Ile Pro Ser Trp Thr Thr Val Ile 
        435                 440                 445             


Leu Val Lys Ser Met Leu Arg Lys Arg Asp Phe Gly Asn Pro Phe Glu 
    450                 455                 460                 


Pro Gln Ala Arg Arg Glu Glu Arg Ser Met Ser Ala Pro Gly Asn Leu 
465                 470                 475                 480 


Leu Val Lys Glu Gly Phe Gly Glu Gly Gly Lys Ser Pro Glu Leu Pro 
                485                 490                 495     


Gly Val Gln Glu Asp Glu Ala Ala Ser 
            500                 505 


<210> 11
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 11
ggauucuaug augaaacuct t                                                 21


<210> 12
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 12
gaguuucauc auagaaucct g                                                 21


<210> 13
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 13
gcaccaucaa agaaggaaat t                                                 21


<210> 14
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 14
uuuccuucuu ugauggugct t                                                 21


<210> 15
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 15
ggugauggug uaaaauacat t                                                 21


<210> 16
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 16
uguauuuuac accaucacct t                                                 21


<210> 17
<211> 88
<212> DNA
<213> Homo sapiens

<400> 17
caccttgtcc tcacggtcca gttttcccag gaatccctta gatgctaaga tggggattcc       60

tggaaatact gttcttgagg tcatggtt                                          88


