                               SEQUENCE LISTING



<110> REGENERON PHARMACEUTICALS, INC.

 

<120> NON-HUMAN ANIMALS HAVING A HUMANIZED CLUSTER OF DIFFERENTIATION 

      47 GENE



<130> 32584 (10108WO01)



<140>

<141>



<150> 62/087,992

<151> 2014-12-05



<160> 36    



<170> PatentIn version 3.5



<210> 1

<211> 5591

<212> DNA

<213> Mus musculus



<400> 1

gcctacaccg ggagagcagg gaggaggagt tggactgagg ttgggcggct ccgaggtcca       60



gggcgagctt ggccagaggg agtagagagc agcggggctg cgcagggacg cgtgccgtga      120



gttccggtga gcgtgtgtgt cccatgctcc cgtctttcag gccggcccag gacacgaagc      180



cggaagagag ctggctggag ggacgggggc cgtgagcaga gagtgcaacc cgcgcagccc      240



cggggacagg ctgattcttg gcgctctccg ccggagcctg cccagggctg ggtgtgaggc      300



tggcgtcacg tcaacgagca gaggcggcca ggcggggcgg agtgcgcgtg cgcggggcgg      360



cgagcacgcg cgcgcgcgca cccccgggca gcctgggcgg ccgctcctgc ctgtcactgc      420



tgcggcgctg ctggtcggtc gtttcccttg aaggcagcag cggaggcggc ggctgctcca      480



gacacctgcg gcggcgaccc cccggcggcg cggagatgtg gcccttggcg gcggcgctgt      540



tgctgggctc ctgctgctgc ggttcagctc aactactgtt tagtaacgtc aactccatag      600



agttcacttc atgcaatgaa actgtggtca tcccttgcat cgtccgtaat gtggaggcgc      660



aaagcaccga agaaatgttt gtgaagtgga agttgaacaa atcgtatatt ttcatctatg      720



atggaaataa aaatagcact actacagatc aaaactttac cagtgcaaaa atctcagtct      780



cagacttaat caatggcatt gcctctttga aaatggataa gcgcgatgcc atggtgggaa      840



actacacttg cgaagtgaca gagttatcca gagaaggcaa aacagttata gagctgaaaa      900



accgcacggc cttcaacact gaccaaggat cagcctgttc ttacgaggag gagaaaggag      960



gttgcaaatt agtttcgtgg ttttctccaa atgaaaagat cctcattgtt attttcccaa     1020



ttttggctat actcctgttc tggggaaagt ttggtatttt aacactcaaa tataaatcca     1080



gccatacgaa taagagaatc attctgctgc tcgttgccgg gctggtgctc acagtcatcg     1140



tggttgttgg agccatcctt ctcatcccag gagaaaagcc cgtgaagaat gcttctggac     1200



ttggcctcat tgtaatctct acggggatat taatactact tcagtacaat gtgtttatga     1260



cagcttttgg aatgacctct ttcaccattg ccatattgat cactcaagtg ctgggctacg     1320



tccttgcttt ggtcgggctg tgtctctgca tcatggcatg tgagccagtg cacggccccc     1380



ttttgatttc aggtttgggg atcatagctc tagcagaact acttggatta gtttatatga     1440



agtttgtcga ataggtgaag ggaagtgacg gactgtaact tggaagtcag aaatggaaga     1500



atacagttgt ctaagcacca ggtcttcacg actcacagct ggaaggaaca gacaacagta     1560



actgacttcc atccaggaaa acatgtcaca taaatgatta ctaagtttat attcaaagca     1620



gctgtacttt acataataaa aaaaatatga tgtgctgtgt aaccaattgg aatcccattt     1680



ttctattgtt tctactcaac taggggcaaa cgtttcaggg gcaacttcca agaatgatgc     1740



ttgttagatc ctagagtctc tgaacactga gtttaaattg attccgagtg agactcgcca     1800



agcactaacc tgagggttag ttacccagag atacctatga aaaacagtgg tatccagcaa     1860



gccttagtaa actcaggttg ccagcagctt tgccacttcc gctgctagct gaataacaag     1920



actgccactt ctgggtcata gtgatagaga ctgaagtaga aaaacgaatg tggttgggca     1980



aatcccgtgt ggcccctctg tgtgctatga tattgatggc actggtgtct tcattcttgg     2040



gggttgccat cattcacaca cacccctttg acatacagtg caccccagtt ttgaatacat     2100



tttttttgca ccctgtcccg ttctgctact ttgatttgcg ttatgatata tatatatata     2160



tataatacct tttctcctct ttaaacatgg tcctgtgaca caatagtcag ttgcagaaag     2220



gagccagact tattcgcaaa gcactgtgct caaactcttc agaaaaaaag gaaaaaaaaa     2280



aaaagctata gttgtaacat atgtattcca gacctctggt ttaaaggcaa aagaaaaaaa     2340



atctacagtg tttcttctca tgttttctga tcggaggcat gacaaagcaa gactgaaatc     2400



tgaactgtgt ctcctgcatg gcaacacgtg tctccgtcag gccctcgcaa ggcccgggga     2460



gggggttcta cgcctcttgt ctctttgttg catgctgaac actcatcgcc ttcctactgt     2520



atcctgcctc ctgcagcctc cctcttcctc ctcctcttcc tcttcctcct cttcctcctc     2580



ctcctcctct tcctccaagt ttgaaaggtc aaacaaaact accacattcc ctacccagtt     2640



agaagaaaac caccgtcctg acagttgtga tcgcatggag tacttttaga ttattagcac     2700



ctgtttttac ctcgtttgtg ggcgtgtttg tatgtgcaca tgtatgaagt cggcacatgc     2760



accttctgta tgggcagagg cgtggcatct acagaagagc agatgccaac tttgtgcttt     2820



tagtgaatac attaaaaaaa aaaaaccaac ggtccttatt gagtggaatt ctatttgatg     2880



caaatatttg agctctttaa gactttaaaa ctagataatg tgccaagctt ttaggactgc     2940



tcaccagtgc cctctgaaga aacaccagta ctttttcctg tttgtgtaat aaaggcatat     3000



ttgtatttgt gtttgcatca ctaatggtta tttcttctta gtccactgaa tgtttccatg     3060



tgcctctcgt atgccaaact ttttgtcatc tttcatgtgg ggaccaaatg gtttgtctgt     3120



ggcaaaccta aacctatgac ctgctgaggc ctctcagaaa actgaccaca gtaccaagat     3180



agtacttcgc aaagaaaagt aggttccctc cctggttttg tagctgtcgc caatattagc     3240



gtaattccaa ggagctgaac gcctttatat aaatctgatg gcacctgatg cttttagttc     3300



tgaaaatatt tacactcgga tcatgttgtt gatgacttaa acaaagtttt gatgaagaga     3360



gcaaaaaaaa agcaggtgga tttggaacag tttcagggtt ttttttgttt tttgtttttt     3420



gtttttgttt tttttttttt atttttgttt ttctgttctc tgttagaaaa gtcaggtgtt     3480



ctctgtcagg ctatctttat agtcaatttt ttttacgaac taaagtagta ccttttaata     3540



tgtagtcaac gcccctctgc tcggggttca gttttgggtc ttaaccagct gtcatgttct     3600



ctatgctgcc tgccacttga ggcactgagt gccctagaca gtcccatcgg tggtagccag     3660



ggaaacgaaa gacgaactca actcttgctc ctaataatca actctctgta tgaaggatgg     3720



cagcattaag agtcctcctg cctgggcatt attgggccag ttcaccctct ttaaatcaaa     3780



cccgcagtgg ctcccagttc tcgtcccatc agatttaaat tgctaacagt atggggggca     3840



ccacgcatct gttttgtccc acaatgcgct tttctctccc aaatcccgat ttctgctgtc     3900



atagcctcta ttcaattttt atttattgtc tgccctccac ttatacaatc gtagagagca     3960



atgccatttg tcactttctg caacagtttt ttgagccttt atggctgaat cccatttttc     4020



ttctctttca aactgtttgc tccattgctc ctcccgcacg gctgtccgta cagtcatccc     4080



atccatctgg gggcctcttt catctctcac ccttcctggt gcttcgtgga tctctgctta     4140



cctctgtggg tttttttttt tttttttgac ttattcttct cactggactt taagattact     4200



tccacagcga aagtgctgcc tcccttttct gcccgcagtg ttctgcgtac tttagatact     4260



actcagtgct gacatttgat ggcaaaagtt gcctgcactt aaatttctct ttttaatagg     4320



gtgaactaga gttggagttt ttttctcttt tttctctttt ctctctctct ctctctctct     4380



ctctctctct ctctctctct ctccctccct ccctccctcc ctccctccct ccctctctct     4440



ctctttttct ttctttcttt ctttctttct ttctttcttt ctttctttct ttctttcttt     4500



ttttgacaaa tctcacaggc tttgagaatt ataaaaggtg acagttcacc tgaaaatcac     4560



aggtctggtc tgtttaaatt gttgagaaat atccgattaa aagtcttgtg gctgtgtcct     4620



aataggctct ctttcaggac gttgtagtca atagagtggc tgaaccatac ttgagtttat     4680



aaagctcaaa aactgatgca cccactctgc tattatcgtg ttagtaagag ttcagctgta     4740



tatcattgtc taggtttatc ttgtcctaca gtgggtattc aaatatggcc accagaggat     4800



atgtgtaaat ataagcacct gtatttgcct gttgttgaga actggaggga aaacaaaaaa     4860



tgtctggcaa ccctttgcct ttttaaccgt aattaattga cagtttattt agagataaga     4920



gttttcaaaa atctcttaac tgccacaacc cacagagggt cttgttttgc catcttcagt     4980



ggctcacaga tatgatccaa gttaacttga aagagatgag cagtacccag gaaattgtcc     5040



tgcctttaac tctggctgtc cttaattatg actgtttaat gctgaatttt ccatccgtct     5100



agtgtttgag ggtaaagaaa agcctttttt aaataagtat ttctgtaaaa cggcatcggt     5160



gggatcttct gtgttgctat cacgggtgaa agagggaaac atttcttatt tttattaagc     5220



agagcattat ttacagaaag ccattgttga gaattagttc ccacatcata taaatatcca     5280



ttaaccattc taaattgtaa gagaactcca gtgttgctat gcacaaggaa ctctcctggg     5340



ggcctttttt tgcatagcaa ttaaaggtat gctatttgtc agtagccatt ttttgcagtg     5400



atttaaagac caaagttgtt ttacagctgt gttaccctta aaggtttttt ttttatgtat     5460



taaatcaatt tatcactgtt tgaagctttg aatacctgca atctttgcca agatactttt     5520



ttatttaaaa aaataactgt gtaaatatta ccctgtaata ttatatatac ttaataaaac     5580



attttaagct a                                                          5591





<210> 2

<211> 312

<212> PRT

<213> Mus musculus



<400> 2

Met Trp Pro Leu Ala Ala Ala Leu Leu Leu Gly Ser Cys Cys Cys Gly 

1               5                   10                  15      





Ser Ala Gln Leu Leu Phe Ser Asn Val Asn Ser Ile Glu Phe Thr Ser 

            20                  25                  30          





Cys Asn Glu Thr Val Val Ile Pro Cys Ile Val Arg Asn Val Glu Ala 

        35                  40                  45              





Gln Ser Thr Glu Glu Met Phe Val Lys Trp Lys Leu Asn Lys Ser Tyr 

    50                  55                  60                  





Ile Phe Ile Tyr Asp Gly Asn Lys Asn Ser Thr Thr Thr Asp Gln Asn 

65                  70                  75                  80  





Phe Thr Ser Ala Lys Ile Ser Val Ser Asp Leu Ile Asn Gly Ile Ala 

                85                  90                  95      





Ser Leu Lys Met Asp Lys Arg Asp Ala Met Val Gly Asn Tyr Thr Cys 

            100                 105                 110         





Glu Val Thr Glu Leu Ser Arg Glu Gly Lys Thr Val Ile Glu Leu Lys 

        115                 120                 125             





Asn Arg Thr Ala Phe Asn Thr Asp Gln Gly Ser Ala Cys Ser Tyr Glu 

    130                 135                 140                 





Glu Glu Lys Gly Gly Cys Lys Leu Val Ser Trp Phe Ser Pro Asn Glu 

145                 150                 155                 160 





Lys Ile Leu Ile Val Ile Phe Pro Ile Leu Ala Ile Leu Leu Phe Trp 

                165                 170                 175     





Gly Lys Phe Gly Ile Leu Thr Leu Lys Tyr Lys Ser Ser His Thr Asn 

            180                 185                 190         





Lys Arg Ile Ile Leu Leu Leu Val Ala Gly Leu Val Leu Thr Val Ile 

        195                 200                 205             





Val Val Val Gly Ala Ile Leu Leu Ile Pro Gly Glu Lys Pro Val Lys 

    210                 215                 220                 





Asn Ala Ser Gly Leu Gly Leu Ile Val Ile Ser Thr Gly Ile Leu Ile 

225                 230                 235                 240 





Leu Leu Gln Tyr Asn Val Phe Met Thr Ala Phe Gly Met Thr Ser Phe 

                245                 250                 255     





Thr Ile Ala Ile Leu Ile Thr Gln Val Leu Gly Tyr Val Leu Ala Leu 

            260                 265                 270         





Val Gly Leu Cys Leu Cys Ile Met Ala Cys Glu Pro Val His Gly Pro 

        275                 280                 285             





Leu Leu Ile Ser Gly Leu Gly Ile Ile Ala Leu Ala Glu Leu Leu Gly 

    290                 295                 300                 





Leu Val Tyr Met Lys Phe Val Glu 

305                 310         





<210> 3

<211> 5560

<212> DNA

<213> Mus musculus



<400> 3

gcctacaccg ggagagcagg gaggaggagt tggactgagg ttgggcggct ccgaggtcca       60



gggcgagctt ggccagaggg agtagagagc agcggggctg cgcagggacg cgtgccgtga      120



gttccggtga gcgtgtgtgt cccatgctcc cgtctttcag gccggcccag gacacgaagc      180



cggaagagag ctggctggag ggacgggggc cgtgagcaga gagtgcaacc cgcgcagccc      240



cggggacagg ctgattcttg gcgctctccg ccggagcctg cccagggctg ggtgtgaggc      300



tggcgtcacg tcaacgagca gaggcggcca ggcggggcgg agtgcgcgtg cgcggggcgg      360



cgagcacgcg cgcgcgcgca cccccgggca gcctgggcgg ccgctcctgc ctgtcactgc      420



tgcggcgctg ctggtcggtc gtttcccttg aaggcagcag cggaggcggc ggctgctcca      480



gacacctgcg gcggcgaccc cccggcggcg cggagatgtg gcccttggcg gcggcgctgt      540



tgctgggctc ctgctgctgc ggttcagctc aactactgtt tagtaacgtc aactccatag      600



agttcacttc atgcaatgaa actgtggtca tcccttgcat cgtccgtaat gtggaggcgc      660



aaagcaccga agaaatgttt gtgaagtgga agttgaacaa atcgtatatt ttcatctatg      720



atggaaataa aaatagcact actacagatc aaaactttac cagtgcaaaa atctcagtct      780



cagacttaat caatggcatt gcctctttga aaatggataa gcgcgatgcc atggtgggaa      840



actacacttg cgaagtgaca gagttatcca gagaaggcaa aacagttata gagctgaaaa      900



accgcacggt ttcgtggttt tctccaaatg aaaagatcct cattgttatt ttcccaattt      960



tggctatact cctgttctgg ggaaagtttg gtattttaac actcaaatat aaatccagcc     1020



atacgaataa gagaatcatt ctgctgctcg ttgccgggct ggtgctcaca gtcatcgtgg     1080



ttgttggagc catccttctc atcccaggag aaaagcccgt gaagaatgct tctggacttg     1140



gcctcattgt aatctctacg gggatattaa tactacttca gtacaatgtg tttatgacag     1200



cttttggaat gacctctttc accattgcca tattgatcac tcaagtgctg ggctacgtcc     1260



ttgctttggt cgggctgtgt ctctgcatca tggcatgtga gccagtgcac ggcccccttt     1320



tgatttcagg tttggggatc atagctctag cagaactact tggattagtt tatatgaagt     1380



ttgtcgcttc caaccagagg actatccaac ctcctaggaa taggtgaagg gaagtgacgg     1440



actgtaactt ggaagtcaga aatggaagaa tacagttgtc taagcaccag gtcttcacga     1500



ctcacagctg gaaggaacag acaacagtaa ctgacttcca tccaggaaaa catgtcacat     1560



aaatgattac taagtttata ttcaaagcag ctgtacttta cataataaaa aaaatatgat     1620



gtgctgtgta accaattgga atcccatttt tctattgttt ctactcaact aggggcaaac     1680



gtttcagggg caacttccaa gaatgatgct tgttagatcc tagagtctct gaacactgag     1740



tttaaattga ttccgagtga gactcgccaa gcactaacct gagggttagt tacccagaga     1800



tacctatgaa aaacagtggt atccagcaag ccttagtaaa ctcaggttgc cagcagcttt     1860



gccacttccg ctgctagctg aataacaaga ctgccacttc tgggtcatag tgatagagac     1920



tgaagtagaa aaacgaatgt ggttgggcaa atcccgtgtg gcccctctgt gtgctatgat     1980



attgatggca ctggtgtctt cattcttggg ggttgccatc attcacacac acccctttga     2040



catacagtgc accccagttt tgaatacatt ttttttgcac cctgtcccgt tctgctactt     2100



tgatttgcgt tatgatatat atatatatat ataatacctt ttctcctctt taaacatggt     2160



cctgtgacac aatagtcagt tgcagaaagg agccagactt attcgcaaag cactgtgctc     2220



aaactcttca gaaaaaaagg aaaaaaaaaa aaagctatag ttgtaacata tgtattccag     2280



acctctggtt taaaggcaaa agaaaaaaaa tctacagtgt ttcttctcat gttttctgat     2340



cggaggcatg acaaagcaag actgaaatct gaactgtgtc tcctgcatgg caacacgtgt     2400



ctccgtcagg ccctcgcaag gcccggggag ggggttctac gcctcttgtc tctttgttgc     2460



atgctgaaca ctcatcgcct tcctactgta tcctgcctcc tgcagcctcc ctcttcctcc     2520



tcctcttcct cttcctcctc ttcctcctcc tcctcctctt cctccaagtt tgaaaggtca     2580



aacaaaacta ccacattccc tacccagtta gaagaaaacc accgtcctga cagttgtgat     2640



cgcatggagt acttttagat tattagcacc tgtttttacc tcgtttgtgg gcgtgtttgt     2700



atgtgcacat gtatgaagtc ggcacatgca ccttctgtat gggcagaggc gtggcatcta     2760



cagaagagca gatgccaact ttgtgctttt agtgaataca ttaaaaaaaa aaaaccaacg     2820



gtccttattg agtggaattc tatttgatgc aaatatttga gctctttaag actttaaaac     2880



tagataatgt gccaagcttt taggactgct caccagtgcc ctctgaagaa acaccagtac     2940



tttttcctgt ttgtgtaata aaggcatatt tgtatttgtg tttgcatcac taatggttat     3000



ttcttcttag tccactgaat gtttccatgt gcctctcgta tgccaaactt tttgtcatct     3060



ttcatgtggg gaccaaatgg tttgtctgtg gcaaacctaa acctatgacc tgctgaggcc     3120



tctcagaaaa ctgaccacag taccaagata gtacttcgca aagaaaagta ggttccctcc     3180



ctggttttgt agctgtcgcc aatattagcg taattccaag gagctgaacg cctttatata     3240



aatctgatgg cacctgatgc ttttagttct gaaaatattt acactcggat catgttgttg     3300



atgacttaaa caaagttttg atgaagagag caaaaaaaaa gcaggtggat ttggaacagt     3360



ttcagggttt tttttgtttt ttgttttttg tttttgtttt ttttttttta tttttgtttt     3420



tctgttctct gttagaaaag tcaggtgttc tctgtcaggc tatctttata gtcaattttt     3480



tttacgaact aaagtagtac cttttaatat gtagtcaacg cccctctgct cggggttcag     3540



ttttgggtct taaccagctg tcatgttctc tatgctgcct gccacttgag gcactgagtg     3600



ccctagacag tcccatcggt ggtagccagg gaaacgaaag acgaactcaa ctcttgctcc     3660



taataatcaa ctctctgtat gaaggatggc agcattaaga gtcctcctgc ctgggcatta     3720



ttgggccagt tcaccctctt taaatcaaac ccgcagtggc tcccagttct cgtcccatca     3780



gatttaaatt gctaacagta tggggggcac cacgcatctg ttttgtccca caatgcgctt     3840



ttctctccca aatcccgatt tctgctgtca tagcctctat tcaattttta tttattgtct     3900



gccctccact tatacaatcg tagagagcaa tgccatttgt cactttctgc aacagttttt     3960



tgagccttta tggctgaatc ccatttttct tctctttcaa actgtttgct ccattgctcc     4020



tcccgcacgg ctgtccgtac agtcatccca tccatctggg ggcctctttc atctctcacc     4080



cttcctggtg cttcgtggat ctctgcttac ctctgtgggt tttttttttt ttttttgact     4140



tattcttctc actggacttt aagattactt ccacagcgaa agtgctgcct cccttttctg     4200



cccgcagtgt tctgcgtact ttagatacta ctcagtgctg acatttgatg gcaaaagttg     4260



cctgcactta aatttctctt tttaataggg tgaactagag ttggagtttt tttctctttt     4320



ttctcttttc tctctctctc tctctctctc tctctctctc tctctctctc tccctccctc     4380



cctccctccc tccctccctc cctctctctc tctttttctt tctttctttc tttctttctt     4440



tctttctttc tttctttctt tctttctttt tttgacaaat ctcacaggct ttgagaatta     4500



taaaaggtga cagttcacct gaaaatcaca ggtctggtct gtttaaattg ttgagaaata     4560



tccgattaaa agtcttgtgg ctgtgtccta ataggctctc tttcaggacg ttgtagtcaa     4620



tagagtggct gaaccatact tgagtttata aagctcaaaa actgatgcac ccactctgct     4680



attatcgtgt tagtaagagt tcagctgtat atcattgtct aggtttatct tgtcctacag     4740



tgggtattca aatatggcca ccagaggata tgtgtaaata taagcacctg tatttgcctg     4800



ttgttgagaa ctggagggaa aacaaaaaat gtctggcaac cctttgcctt tttaaccgta     4860



attaattgac agtttattta gagataagag ttttcaaaaa tctcttaact gccacaaccc     4920



acagagggtc ttgttttgcc atcttcagtg gctcacagat atgatccaag ttaacttgaa     4980



agagatgagc agtacccagg aaattgtcct gcctttaact ctggctgtcc ttaattatga     5040



ctgtttaatg ctgaattttc catccgtcta gtgtttgagg gtaaagaaaa gcctttttta     5100



aataagtatt tctgtaaaac ggcatcggtg ggatcttctg tgttgctatc acgggtgaaa     5160



gagggaaaca tttcttattt ttattaagca gagcattatt tacagaaagc cattgttgag     5220



aattagttcc cacatcatat aaatatccat taaccattct aaattgtaag agaactccag     5280



tgttgctatg cacaaggaac tctcctgggg gccttttttt gcatagcaat taaaggtatg     5340



ctatttgtca gtagccattt tttgcagtga tttaaagacc aaagttgttt tacagctgtg     5400



ttacccttaa aggttttttt tttatgtatt aaatcaattt atcactgttt gaagctttga     5460



atacctgcaa tctttgccaa gatacttttt tatttaaaaa aataactgtg taaatattac     5520



cctgtaatat tatatatact taataaaaca ttttaagcta                           5560





<210> 4

<211> 303

<212> PRT

<213> Mus musculus



<400> 4

Met Trp Pro Leu Ala Ala Ala Leu Leu Leu Gly Ser Cys Cys Cys Gly 

1               5                   10                  15      





Ser Ala Gln Leu Leu Phe Ser Asn Val Asn Ser Ile Glu Phe Thr Ser 

            20                  25                  30          





Cys Asn Glu Thr Val Val Ile Pro Cys Ile Val Arg Asn Val Glu Ala 

        35                  40                  45              





Gln Ser Thr Glu Glu Met Phe Val Lys Trp Lys Leu Asn Lys Ser Tyr 

    50                  55                  60                  





Ile Phe Ile Tyr Asp Gly Asn Lys Asn Ser Thr Thr Thr Asp Gln Asn 

65                  70                  75                  80  





Phe Thr Ser Ala Lys Ile Ser Val Ser Asp Leu Ile Asn Gly Ile Ala 

                85                  90                  95      





Ser Leu Lys Met Asp Lys Arg Asp Ala Met Val Gly Asn Tyr Thr Cys 

            100                 105                 110         





Glu Val Thr Glu Leu Ser Arg Glu Gly Lys Thr Val Ile Glu Leu Lys 

        115                 120                 125             





Asn Arg Thr Val Ser Trp Phe Ser Pro Asn Glu Lys Ile Leu Ile Val 

    130                 135                 140                 





Ile Phe Pro Ile Leu Ala Ile Leu Leu Phe Trp Gly Lys Phe Gly Ile 

145                 150                 155                 160 





Leu Thr Leu Lys Tyr Lys Ser Ser His Thr Asn Lys Arg Ile Ile Leu 

                165                 170                 175     





Leu Leu Val Ala Gly Leu Val Leu Thr Val Ile Val Val Val Gly Ala 

            180                 185                 190         





Ile Leu Leu Ile Pro Gly Glu Lys Pro Val Lys Asn Ala Ser Gly Leu 

        195                 200                 205             





Gly Leu Ile Val Ile Ser Thr Gly Ile Leu Ile Leu Leu Gln Tyr Asn 

    210                 215                 220                 





Val Phe Met Thr Ala Phe Gly Met Thr Ser Phe Thr Ile Ala Ile Leu 

225                 230                 235                 240 





Ile Thr Gln Val Leu Gly Tyr Val Leu Ala Leu Val Gly Leu Cys Leu 

                245                 250                 255     





Cys Ile Met Ala Cys Glu Pro Val His Gly Pro Leu Leu Ile Ser Gly 

            260                 265                 270         





Leu Gly Ile Ile Ala Leu Ala Glu Leu Leu Gly Leu Val Tyr Met Lys 

        275                 280                 285             





Phe Val Ala Ser Asn Gln Arg Thr Ile Gln Pro Pro Arg Asn Arg 

    290                 295                 300             





<210> 5

<211> 5648

<212> DNA

<213> Mus musculus



<400> 5

gcctacaccg ggagagcagg gaggaggagt tggactgagg ttgggcggct ccgaggtcca       60



gggcgagctt ggccagaggg agtagagagc agcggggctg cgcagggacg cgtgccgtga      120



gttccggtga gcgtgtgtgt cccatgctcc cgtctttcag gccggcccag gacacgaagc      180



cggaagagag ctggctggag ggacgggggc cgtgagcaga gagtgcaacc cgcgcagccc      240



cggggacagg ctgattcttg gcgctctccg ccggagcctg cccagggctg ggtgtgaggc      300



tggcgtcacg tcaacgagca gaggcggcca ggcggggcgg agtgcgcgtg cgcggggcgg      360



cgagcacgcg cgcgcgcgca cccccgggca gcctgggcgg ccgctcctgc ctgtcactgc      420



tgcggcgctg ctggtcggtc gtttcccttg aaggcagcag cggaggcggc ggctgctcca      480



gacacctgcg gcggcgaccc cccggcggcg cggagatgtg gcccttggcg gcggcgctgt      540



tgctgggctc ctgctgctgc ggttcagctc aactactgtt tagtaacgtc aactccatag      600



agttcacttc atgcaatgaa actgtggtca tcccttgcat cgtccgtaat gtggaggcgc      660



aaagcaccga agaaatgttt gtgaagtgga agttgaacaa atcgtatatt ttcatctatg      720



atggaaataa aaatagcact actacagatc aaaactttac cagtgcaaaa atctcagtct      780



cagacttaat caatggcatt gcctctttga aaatggataa gcgcgatgcc atggtgggaa      840



actacacttg cgaagtgaca gagttatcca gagaaggcaa aacagttata gagctgaaaa      900



accgcacggc cttcaacact gaccaaggat cagcctgttc ttacgaggag gagaaaggag      960



gttgcaaatt agtttcgtgg ttttctccaa atgaaaagat cctcattgtt attttcccaa     1020



ttttggctat actcctgttc tggggaaagt ttggtatttt aacactcaaa tataaatcca     1080



gccatacgaa taagagaatc attctgctgc tcgttgccgg gctggtgctc acagtcatcg     1140



tggttgttgg agccatcctt ctcatcccag gagaaaagcc cgtgaagaat gcttctggac     1200



ttggcctcat tgtaatctct acggggatat taatactact tcagtacaat gtgtttatga     1260



cagcttttgg aatgacctct ttcaccattg ccatattgat cactcaagtg ctgggctacg     1320



tccttgcttt ggtcgggctg tgtctctgca tcatggcatg tgagccagtg cacggccccc     1380



ttttgatttc aggtttgggg atcatagctc tagcagaact acttggatta gtttatatga     1440



agtttgtcgc ttccaaccag aggactatcc aacctcctag gaaagctgta gaggaacccc     1500



ttaacgaata ggtgaaggga agtgacggac tgtaacttgg aagtcagaaa tggaagaata     1560



cagttgtcta agcaccaggt cttcacgact cacagctgga aggaacagac aacagtaact     1620



gacttccatc caggaaaaca tgtcacataa atgattacta agtttatatt caaagcagct     1680



gtactttaca taataaaaaa aatatgatgt gctgtgtaac caattggaat cccatttttc     1740



tattgtttct actcaactag gggcaaacgt ttcaggggca acttccaaga atgatgcttg     1800



ttagatccta gagtctctga acactgagtt taaattgatt ccgagtgaga ctcgccaagc     1860



actaacctga gggttagtta cccagagata cctatgaaaa acagtggtat ccagcaagcc     1920



ttagtaaact caggttgcca gcagctttgc cacttccgct gctagctgaa taacaagact     1980



gccacttctg ggtcatagtg atagagactg aagtagaaaa acgaatgtgg ttgggcaaat     2040



cccgtgtggc ccctctgtgt gctatgatat tgatggcact ggtgtcttca ttcttggggg     2100



ttgccatcat tcacacacac ccctttgaca tacagtgcac cccagttttg aatacatttt     2160



ttttgcaccc tgtcccgttc tgctactttg atttgcgtta tgatatatat atatatatat     2220



aatacctttt ctcctcttta aacatggtcc tgtgacacaa tagtcagttg cagaaaggag     2280



ccagacttat tcgcaaagca ctgtgctcaa actcttcaga aaaaaaggaa aaaaaaaaaa     2340



agctatagtt gtaacatatg tattccagac ctctggttta aaggcaaaag aaaaaaaatc     2400



tacagtgttt cttctcatgt tttctgatcg gaggcatgac aaagcaagac tgaaatctga     2460



actgtgtctc ctgcatggca acacgtgtct ccgtcaggcc ctcgcaaggc ccggggaggg     2520



ggttctacgc ctcttgtctc tttgttgcat gctgaacact catcgccttc ctactgtatc     2580



ctgcctcctg cagcctccct cttcctcctc ctcttcctct tcctcctctt cctcctcctc     2640



ctcctcttcc tccaagtttg aaaggtcaaa caaaactacc acattcccta cccagttaga     2700



agaaaaccac cgtcctgaca gttgtgatcg catggagtac ttttagatta ttagcacctg     2760



tttttacctc gtttgtgggc gtgtttgtat gtgcacatgt atgaagtcgg cacatgcacc     2820



ttctgtatgg gcagaggcgt ggcatctaca gaagagcaga tgccaacttt gtgcttttag     2880



tgaatacatt aaaaaaaaaa aaccaacggt ccttattgag tggaattcta tttgatgcaa     2940



atatttgagc tctttaagac tttaaaacta gataatgtgc caagctttta ggactgctca     3000



ccagtgccct ctgaagaaac accagtactt tttcctgttt gtgtaataaa ggcatatttg     3060



tatttgtgtt tgcatcacta atggttattt cttcttagtc cactgaatgt ttccatgtgc     3120



ctctcgtatg ccaaactttt tgtcatcttt catgtgggga ccaaatggtt tgtctgtggc     3180



aaacctaaac ctatgacctg ctgaggcctc tcagaaaact gaccacagta ccaagatagt     3240



acttcgcaaa gaaaagtagg ttccctccct ggttttgtag ctgtcgccaa tattagcgta     3300



attccaagga gctgaacgcc tttatataaa tctgatggca cctgatgctt ttagttctga     3360



aaatatttac actcggatca tgttgttgat gacttaaaca aagttttgat gaagagagca     3420



aaaaaaaagc aggtggattt ggaacagttt cagggttttt tttgtttttt gttttttgtt     3480



tttgtttttt tttttttatt tttgtttttc tgttctctgt tagaaaagtc aggtgttctc     3540



tgtcaggcta tctttatagt caattttttt tacgaactaa agtagtacct tttaatatgt     3600



agtcaacgcc cctctgctcg gggttcagtt ttgggtctta accagctgtc atgttctcta     3660



tgctgcctgc cacttgaggc actgagtgcc ctagacagtc ccatcggtgg tagccaggga     3720



aacgaaagac gaactcaact cttgctccta ataatcaact ctctgtatga aggatggcag     3780



cattaagagt cctcctgcct gggcattatt gggccagttc accctcttta aatcaaaccc     3840



gcagtggctc ccagttctcg tcccatcaga tttaaattgc taacagtatg gggggcacca     3900



cgcatctgtt ttgtcccaca atgcgctttt ctctcccaaa tcccgatttc tgctgtcata     3960



gcctctattc aatttttatt tattgtctgc cctccactta tacaatcgta gagagcaatg     4020



ccatttgtca ctttctgcaa cagttttttg agcctttatg gctgaatccc atttttcttc     4080



tctttcaaac tgtttgctcc attgctcctc ccgcacggct gtccgtacag tcatcccatc     4140



catctggggg cctctttcat ctctcaccct tcctggtgct tcgtggatct ctgcttacct     4200



ctgtgggttt tttttttttt ttttgactta ttcttctcac tggactttaa gattacttcc     4260



acagcgaaag tgctgcctcc cttttctgcc cgcagtgttc tgcgtacttt agatactact     4320



cagtgctgac atttgatggc aaaagttgcc tgcacttaaa tttctctttt taatagggtg     4380



aactagagtt ggagtttttt tctctttttt ctcttttctc tctctctctc tctctctctc     4440



tctctctctc tctctctctc cctccctccc tccctccctc cctccctccc tctctctctc     4500



tttttctttc tttctttctt tctttctttc tttctttctt tctttctttc tttctttttt     4560



tgacaaatct cacaggcttt gagaattata aaaggtgaca gttcacctga aaatcacagg     4620



tctggtctgt ttaaattgtt gagaaatatc cgattaaaag tcttgtggct gtgtcctaat     4680



aggctctctt tcaggacgtt gtagtcaata gagtggctga accatacttg agtttataaa     4740



gctcaaaaac tgatgcaccc actctgctat tatcgtgtta gtaagagttc agctgtatat     4800



cattgtctag gtttatcttg tcctacagtg ggtattcaaa tatggccacc agaggatatg     4860



tgtaaatata agcacctgta tttgcctgtt gttgagaact ggagggaaaa caaaaaatgt     4920



ctggcaaccc tttgcctttt taaccgtaat taattgacag tttatttaga gataagagtt     4980



ttcaaaaatc tcttaactgc cacaacccac agagggtctt gttttgccat cttcagtggc     5040



tcacagatat gatccaagtt aacttgaaag agatgagcag tacccaggaa attgtcctgc     5100



ctttaactct ggctgtcctt aattatgact gtttaatgct gaattttcca tccgtctagt     5160



gtttgagggt aaagaaaagc cttttttaaa taagtatttc tgtaaaacgg catcggtggg     5220



atcttctgtg ttgctatcac gggtgaaaga gggaaacatt tcttattttt attaagcaga     5280



gcattattta cagaaagcca ttgttgagaa ttagttccca catcatataa atatccatta     5340



accattctaa attgtaagag aactccagtg ttgctatgca caaggaactc tcctgggggc     5400



ctttttttgc atagcaatta aaggtatgct atttgtcagt agccattttt tgcagtgatt     5460



taaagaccaa agttgtttta cagctgtgtt acccttaaag gttttttttt tatgtattaa     5520



atcaatttat cactgtttga agctttgaat acctgcaatc tttgccaaga tactttttta     5580



tttaaaaaaa taactgtgta aatattaccc tgtaatatta tatatactta ataaaacatt     5640



ttaagcta                                                              5648





<210> 6

<211> 331

<212> PRT

<213> Mus musculus



<400> 6

Met Trp Pro Leu Ala Ala Ala Leu Leu Leu Gly Ser Cys Cys Cys Gly 

1               5                   10                  15      





Ser Ala Gln Leu Leu Phe Ser Asn Val Asn Ser Ile Glu Phe Thr Ser 

            20                  25                  30          





Cys Asn Glu Thr Val Val Ile Pro Cys Ile Val Arg Asn Val Glu Ala 

        35                  40                  45              





Gln Ser Thr Glu Glu Met Phe Val Lys Trp Lys Leu Asn Lys Ser Tyr 

    50                  55                  60                  





Ile Phe Ile Tyr Asp Gly Asn Lys Asn Ser Thr Thr Thr Asp Gln Asn 

65                  70                  75                  80  





Phe Thr Ser Ala Lys Ile Ser Val Ser Asp Leu Ile Asn Gly Ile Ala 

                85                  90                  95      





Ser Leu Lys Met Asp Lys Arg Asp Ala Met Val Gly Asn Tyr Thr Cys 

            100                 105                 110         





Glu Val Thr Glu Leu Ser Arg Glu Gly Lys Thr Val Ile Glu Leu Lys 

        115                 120                 125             





Asn Arg Thr Ala Phe Asn Thr Asp Gln Gly Ser Ala Cys Ser Tyr Glu 

    130                 135                 140                 





Glu Glu Lys Gly Gly Cys Lys Leu Val Ser Trp Phe Ser Pro Asn Glu 

145                 150                 155                 160 





Lys Ile Leu Ile Val Ile Phe Pro Ile Leu Ala Ile Leu Leu Phe Trp 

                165                 170                 175     





Gly Lys Phe Gly Ile Leu Thr Leu Lys Tyr Lys Ser Ser His Thr Asn 

            180                 185                 190         





Lys Arg Ile Ile Leu Leu Leu Val Ala Gly Leu Val Leu Thr Val Ile 

        195                 200                 205             





Val Val Val Gly Ala Ile Leu Leu Ile Pro Gly Glu Lys Pro Val Lys 

    210                 215                 220                 





Asn Ala Ser Gly Leu Gly Leu Ile Val Ile Ser Thr Gly Ile Leu Ile 

225                 230                 235                 240 





Leu Leu Gln Tyr Asn Val Phe Met Thr Ala Phe Gly Met Thr Ser Phe 

                245                 250                 255     





Thr Ile Ala Ile Leu Ile Thr Gln Val Leu Gly Tyr Val Leu Ala Leu 

            260                 265                 270         





Val Gly Leu Cys Leu Cys Ile Met Ala Cys Glu Pro Val His Gly Pro 

        275                 280                 285             





Leu Leu Ile Ser Gly Leu Gly Ile Ile Ala Leu Ala Glu Leu Leu Gly 

    290                 295                 300                 





Leu Val Tyr Met Lys Phe Val Ala Ser Asn Gln Arg Thr Ile Gln Pro 

305                 310                 315                 320 





Pro Arg Lys Ala Val Glu Glu Pro Leu Asn Glu 

                325                 330     





<210> 7

<211> 5618

<212> DNA

<213> Mus musculus



<400> 7

gcctacaccg ggagagcagg gaggaggagt tggactgagg ttgggcggct ccgaggtcca       60



gggcgagctt ggccagaggg agtagagagc agcggggctg cgcagggacg cgtgccgtga      120



gttccggtga gcgtgtgtgt cccatgctcc cgtctttcag gccggcccag gacacgaagc      180



cggaagagag ctggctggag ggacgggggc cgtgagcaga gagtgcaacc cgcgcagccc      240



cggggacagg ctgattcttg gcgctctccg ccggagcctg cccagggctg ggtgtgaggc      300



tggcgtcacg tcaacgagca gaggcggcca ggcggggcgg agtgcgcgtg cgcggggcgg      360



cgagcacgcg cgcgcgcgca cccccgggca gcctgggcgg ccgctcctgc ctgtcactgc      420



tgcggcgctg ctggtcggtc gtttcccttg aaggcagcag cggaggcggc ggctgctcca      480



gacacctgcg gcggcgaccc cccggcggcg cggagatgtg gcccttggcg gcggcgctgt      540



tgctgggctc ctgctgctgc ggttcagctc aactactgtt tagtaacgtc aactccatag      600



agttcacttc atgcaatgaa actgtggtca tcccttgcat cgtccgtaat gtggaggcgc      660



aaagcaccga agaaatgttt gtgaagtgga agttgaacaa atcgtatatt ttcatctatg      720



atggaaataa aaatagcact actacagatc aaaactttac cagtgcaaaa atctcagtct      780



cagacttaat caatggcatt gcctctttga aaatggataa gcgcgatgcc atggtgggaa      840



actacacttg cgaagtgaca gagttatcca gagaaggcaa aacagttata gagctgaaaa      900



accgcacggt ttcgtggttt tctccaaatg aaaagatcct cattgttatt ttcccaattt      960



tggctatact cctgttctgg ggaaagtttg gtattttaac actcaaatat aaatccagcc     1020



atacgaataa gagaatcatt ctgctgctcg ttgccgggct ggtgctcaca gtcatcgtgg     1080



ttgttggagc catccttctc atcccaggag aaaagcccgt gaagaatgct tctggacttg     1140



gcctcattgt aatctctacg gggatattaa tactacttca gtacaatgtg tttatgacag     1200



cttttggaat gacctctttc accattgcca tattgatcac tcaagtgctg ggctacgtcc     1260



ttgctttggt cgggctgtgt ctctgcatca tggcatgtga gccagtgcac ggcccccttt     1320



tgatttcagg tttggggatc atagctctag cagaactact tggattagtt tatatgaagt     1380



ttgtcgcttc caaccagagg actatccaac ctcctaggaa agctgtagag gaacccctta     1440



acgcatttaa agagtcaaaa ggaatgatga atgacgaata ggtgaaggga agtgacggac     1500



tgtaacttgg aagtcagaaa tggaagaata cagttgtcta agcaccaggt cttcacgact     1560



cacagctgga aggaacagac aacagtaact gacttccatc caggaaaaca tgtcacataa     1620



atgattacta agtttatatt caaagcagct gtactttaca taataaaaaa aatatgatgt     1680



gctgtgtaac caattggaat cccatttttc tattgtttct actcaactag gggcaaacgt     1740



ttcaggggca acttccaaga atgatgcttg ttagatccta gagtctctga acactgagtt     1800



taaattgatt ccgagtgaga ctcgccaagc actaacctga gggttagtta cccagagata     1860



cctatgaaaa acagtggtat ccagcaagcc ttagtaaact caggttgcca gcagctttgc     1920



cacttccgct gctagctgaa taacaagact gccacttctg ggtcatagtg atagagactg     1980



aagtagaaaa acgaatgtgg ttgggcaaat cccgtgtggc ccctctgtgt gctatgatat     2040



tgatggcact ggtgtcttca ttcttggggg ttgccatcat tcacacacac ccctttgaca     2100



tacagtgcac cccagttttg aatacatttt ttttgcaccc tgtcccgttc tgctactttg     2160



atttgcgtta tgatatatat atatatatat aatacctttt ctcctcttta aacatggtcc     2220



tgtgacacaa tagtcagttg cagaaaggag ccagacttat tcgcaaagca ctgtgctcaa     2280



actcttcaga aaaaaaggaa aaaaaaaaaa agctatagtt gtaacatatg tattccagac     2340



ctctggttta aaggcaaaag aaaaaaaatc tacagtgttt cttctcatgt tttctgatcg     2400



gaggcatgac aaagcaagac tgaaatctga actgtgtctc ctgcatggca acacgtgtct     2460



ccgtcaggcc ctcgcaaggc ccggggaggg ggttctacgc ctcttgtctc tttgttgcat     2520



gctgaacact catcgccttc ctactgtatc ctgcctcctg cagcctccct cttcctcctc     2580



ctcttcctct tcctcctctt cctcctcctc ctcctcttcc tccaagtttg aaaggtcaaa     2640



caaaactacc acattcccta cccagttaga agaaaaccac cgtcctgaca gttgtgatcg     2700



catggagtac ttttagatta ttagcacctg tttttacctc gtttgtgggc gtgtttgtat     2760



gtgcacatgt atgaagtcgg cacatgcacc ttctgtatgg gcagaggcgt ggcatctaca     2820



gaagagcaga tgccaacttt gtgcttttag tgaatacatt aaaaaaaaaa aaccaacggt     2880



ccttattgag tggaattcta tttgatgcaa atatttgagc tctttaagac tttaaaacta     2940



gataatgtgc caagctttta ggactgctca ccagtgccct ctgaagaaac accagtactt     3000



tttcctgttt gtgtaataaa ggcatatttg tatttgtgtt tgcatcacta atggttattt     3060



cttcttagtc cactgaatgt ttccatgtgc ctctcgtatg ccaaactttt tgtcatcttt     3120



catgtgggga ccaaatggtt tgtctgtggc aaacctaaac ctatgacctg ctgaggcctc     3180



tcagaaaact gaccacagta ccaagatagt acttcgcaaa gaaaagtagg ttccctccct     3240



ggttttgtag ctgtcgccaa tattagcgta attccaagga gctgaacgcc tttatataaa     3300



tctgatggca cctgatgctt ttagttctga aaatatttac actcggatca tgttgttgat     3360



gacttaaaca aagttttgat gaagagagca aaaaaaaagc aggtggattt ggaacagttt     3420



cagggttttt tttgtttttt gttttttgtt tttgtttttt tttttttatt tttgtttttc     3480



tgttctctgt tagaaaagtc aggtgttctc tgtcaggcta tctttatagt caattttttt     3540



tacgaactaa agtagtacct tttaatatgt agtcaacgcc cctctgctcg gggttcagtt     3600



ttgggtctta accagctgtc atgttctcta tgctgcctgc cacttgaggc actgagtgcc     3660



ctagacagtc ccatcggtgg tagccaggga aacgaaagac gaactcaact cttgctccta     3720



ataatcaact ctctgtatga aggatggcag cattaagagt cctcctgcct gggcattatt     3780



gggccagttc accctcttta aatcaaaccc gcagtggctc ccagttctcg tcccatcaga     3840



tttaaattgc taacagtatg gggggcacca cgcatctgtt ttgtcccaca atgcgctttt     3900



ctctcccaaa tcccgatttc tgctgtcata gcctctattc aatttttatt tattgtctgc     3960



cctccactta tacaatcgta gagagcaatg ccatttgtca ctttctgcaa cagttttttg     4020



agcctttatg gctgaatccc atttttcttc tctttcaaac tgtttgctcc attgctcctc     4080



ccgcacggct gtccgtacag tcatcccatc catctggggg cctctttcat ctctcaccct     4140



tcctggtgct tcgtggatct ctgcttacct ctgtgggttt tttttttttt ttttgactta     4200



ttcttctcac tggactttaa gattacttcc acagcgaaag tgctgcctcc cttttctgcc     4260



cgcagtgttc tgcgtacttt agatactact cagtgctgac atttgatggc aaaagttgcc     4320



tgcacttaaa tttctctttt taatagggtg aactagagtt ggagtttttt tctctttttt     4380



ctcttttctc tctctctctc tctctctctc tctctctctc tctctctctc cctccctccc     4440



tccctccctc cctccctccc tctctctctc tttttctttc tttctttctt tctttctttc     4500



tttctttctt tctttctttc tttctttttt tgacaaatct cacaggcttt gagaattata     4560



aaaggtgaca gttcacctga aaatcacagg tctggtctgt ttaaattgtt gagaaatatc     4620



cgattaaaag tcttgtggct gtgtcctaat aggctctctt tcaggacgtt gtagtcaata     4680



gagtggctga accatacttg agtttataaa gctcaaaaac tgatgcaccc actctgctat     4740



tatcgtgtta gtaagagttc agctgtatat cattgtctag gtttatcttg tcctacagtg     4800



ggtattcaaa tatggccacc agaggatatg tgtaaatata agcacctgta tttgcctgtt     4860



gttgagaact ggagggaaaa caaaaaatgt ctggcaaccc tttgcctttt taaccgtaat     4920



taattgacag tttatttaga gataagagtt ttcaaaaatc tcttaactgc cacaacccac     4980



agagggtctt gttttgccat cttcagtggc tcacagatat gatccaagtt aacttgaaag     5040



agatgagcag tacccaggaa attgtcctgc ctttaactct ggctgtcctt aattatgact     5100



gtttaatgct gaattttcca tccgtctagt gtttgagggt aaagaaaagc cttttttaaa     5160



taagtatttc tgtaaaacgg catcggtggg atcttctgtg ttgctatcac gggtgaaaga     5220



gggaaacatt tcttattttt attaagcaga gcattattta cagaaagcca ttgttgagaa     5280



ttagttccca catcatataa atatccatta accattctaa attgtaagag aactccagtg     5340



ttgctatgca caaggaactc tcctgggggc ctttttttgc atagcaatta aaggtatgct     5400



atttgtcagt agccattttt tgcagtgatt taaagaccaa agttgtttta cagctgtgtt     5460



acccttaaag gttttttttt tatgtattaa atcaatttat cactgtttga agctttgaat     5520



acctgcaatc tttgccaaga tactttttta tttaaaaaaa taactgtgta aatattaccc     5580



tgtaatatta tatatactta ataaaacatt ttaagcta                             5618





<210> 8

<211> 321

<212> PRT

<213> Mus musculus



<400> 8

Met Trp Pro Leu Ala Ala Ala Leu Leu Leu Gly Ser Cys Cys Cys Gly 

1               5                   10                  15      





Ser Ala Gln Leu Leu Phe Ser Asn Val Asn Ser Ile Glu Phe Thr Ser 

            20                  25                  30          





Cys Asn Glu Thr Val Val Ile Pro Cys Ile Val Arg Asn Val Glu Ala 

        35                  40                  45              





Gln Ser Thr Glu Glu Met Phe Val Lys Trp Lys Leu Asn Lys Ser Tyr 

    50                  55                  60                  





Ile Phe Ile Tyr Asp Gly Asn Lys Asn Ser Thr Thr Thr Asp Gln Asn 

65                  70                  75                  80  





Phe Thr Ser Ala Lys Ile Ser Val Ser Asp Leu Ile Asn Gly Ile Ala 

                85                  90                  95      





Ser Leu Lys Met Asp Lys Arg Asp Ala Met Val Gly Asn Tyr Thr Cys 

            100                 105                 110         





Glu Val Thr Glu Leu Ser Arg Glu Gly Lys Thr Val Ile Glu Leu Lys 

        115                 120                 125             





Asn Arg Thr Val Ser Trp Phe Ser Pro Asn Glu Lys Ile Leu Ile Val 

    130                 135                 140                 





Ile Phe Pro Ile Leu Ala Ile Leu Leu Phe Trp Gly Lys Phe Gly Ile 

145                 150                 155                 160 





Leu Thr Leu Lys Tyr Lys Ser Ser His Thr Asn Lys Arg Ile Ile Leu 

                165                 170                 175     





Leu Leu Val Ala Gly Leu Val Leu Thr Val Ile Val Val Val Gly Ala 

            180                 185                 190         





Ile Leu Leu Ile Pro Gly Glu Lys Pro Val Lys Asn Ala Ser Gly Leu 

        195                 200                 205             





Gly Leu Ile Val Ile Ser Thr Gly Ile Leu Ile Leu Leu Gln Tyr Asn 

    210                 215                 220                 





Val Phe Met Thr Ala Phe Gly Met Thr Ser Phe Thr Ile Ala Ile Leu 

225                 230                 235                 240 





Ile Thr Gln Val Leu Gly Tyr Val Leu Ala Leu Val Gly Leu Cys Leu 

                245                 250                 255     





Cys Ile Met Ala Cys Glu Pro Val His Gly Pro Leu Leu Ile Ser Gly 

            260                 265                 270         





Leu Gly Ile Ile Ala Leu Ala Glu Leu Leu Gly Leu Val Tyr Met Lys 

        275                 280                 285             





Phe Val Ala Ser Asn Gln Arg Thr Ile Gln Pro Pro Arg Lys Ala Val 

    290                 295                 300                 





Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met Asn Asp 

305                 310                 315                 320 





Glu 

    





<210> 9

<211> 5021

<212> DNA

<213> Homo sapiens



<400> 9

agtgggagcg cgcgtgcgcg cggccgtgca gcctgggcag tgggtcctgc ctgtgacgcg       60



cggcggcggt cggtcctgcc tgtaacggcg gcggcggctg ctgctccgga cacctgcggc      120



ggcggcggcg accccgcggc gggcgcggag atgtggcccc tggtagcggc gctgttgctg      180



ggctcggcgt gctgcggatc agctcagcta ctatttaata aaacaaaatc tgtagaattc      240



acgttttgta atgacactgt cgtcattcca tgctttgtta ctaatatgga ggcacaaaac      300



actactgaag tatacgtaaa gtggaaattt aaaggaagag atatttacac ctttgatgga      360



gctctaaaca agtccactgt ccccactgac tttagtagtg caaaaattga agtctcacaa      420



ttactaaaag gagatgcctc tttgaagatg gataagagtg atgctgtctc acacacagga      480



aactacactt gtgaagtaac agaattaacc agagaaggtg aaacgatcat cgagctaaaa      540



tatcgtgttg tttcatggtt ttctccaaat gaaaatattc ttattgttat tttcccaatt      600



tttgctatac tcctgttctg gggacagttt ggtattaaaa cacttaaata tagatccggt      660



ggtatggatg agaaaacaat tgctttactt gttgctggac tagtgatcac tgtcattgtc      720



attgttggag ccattctttt cgtcccaggt gaatattcat taaagaatgc tactggcctt      780



ggtttaattg tgacttctac agggatatta atattacttc actactatgt gtttagtaca      840



gcgattggat taacctcctt cgtcattgcc atattggtta ttcaggtgat agcctatatc      900



ctcgctgtgg ttggactgag tctctgtatt gcggcgtgta taccaatgca tggccctctt      960



ctgatttcag gtttgagtat cttagctcta gcacaattac ttggactagt ttatatgaaa     1020



tttgtggaat aactgaagtg aagtgatgga ctccgatttg gagagtagta agacgtgaaa     1080



ggaatacact tgtgtttaag caccatggcc ttgatgattc actgttgggg agaagaaaca     1140



agaaaagtaa ctggttgtca cctatgagac ccttacgtga ttgttagtta agtttttatt     1200



caaagcagct gtaatttagt taataaaata attatgatct atgttgtttg cccaattgag     1260



atccagtttt ttgttgttat ttttaatcaa ttaggggcaa tagtagaatg gacaatttcc     1320



aagaatgatg cctttcaggt cctagggcct ctggcctcta ggtaaccagt ttaaattggt     1380



tcagggtgat aactacttag cactgccctg gtgattaccc agagatatct atgaaaacca     1440



gtggcttcca tcaaaccttt gccaactcag gttcacagca gctttgggca gttatggcag     1500



tatggcatta gctgagaggt gtctgccact tctgggtcaa tggaataata aattaagtac     1560



aggcaggaat ttggttggga gcatcttgta tgatctccgt atgatgtgat attgatggag     1620



atagtggtcc tcattcttgg gggttgccat tcccacattc ccccttcaac aaacagtgta     1680



acaggtcctt cccagattta gggtactttt attgatggat atgttttcct tttattcaca     1740



taaccccttg aaaccctgtc ttgtcctcct gttacttgct tctgctgtac aagatgtagc     1800



accttttctc ctctttgaac atggtctagt gacacggtag caccagttgc aggaaggagc     1860



cagacttgtt ctcagagcac tgtgttcaca cttttcagca aaaatagcta tggttgtaac     1920



atatgtattc ccttcctctg atttgaaggc aaaaatctac agtgtttctt cacttctttt     1980



ctgatctggg gcatgaaaaa agcaagattg aaatttgaac tatgagtctc ctgcatggca     2040



acaaaatgtg tgtcaccatc aggccaacag gccagccctt gaatggggat ttattactgt     2100



tgtatctatg ttgcatgata aacattcatc accttcctcc tgtagtcctg cctcgtactc     2160



cccttcccct atgattgaaa agtaaacaaa acccacattt cctatcctgg ttagaagaaa     2220



attaatgttc tgacagttgt gatcgcctgg agtactttta gacttttagc attcgttttt     2280



tacctgtttg tggatgtgtg tttgtatgtg catacgtatg agataggcac atgcatcttc     2340



tgtatggaca aaggtggggt acctacagga gagcaaaggt taattttgtg cttttagtaa     2400



aaacatttaa atacaaagtt ctttattggg tggaattata tttgatgcaa atatttgatc     2460



acttaaaact tttaaaactt ctaggtaatt tgccacgctt tttgactgct caccaatacc     2520



ctgtaaaaat acgtaattct tcctgtttgt gtaataagat attcatattt gtagttgcat     2580



taataatagt tatttcttag tccatcagat gttcccgtgt gcctctttta tgccaaattg     2640



attgtcatat ttcatgttgg gaccaagtag tttgcccatg gcaaacctaa atttatgacc     2700



tgctgaggcc tctcagaaaa ctgagcatac tagcaagaca gctcttcttg aaaaaaaaaa     2760



tatgtataca caaatatata cgtatatcta tatatacgta tgtatataca cacatgtata     2820



ttcttccttg attgtgtagc tgtccaaaat aataacatat atagagggag ctgtattcct     2880



ttatacaaat ctgatggctc ctgcagcact ttttccttct gaaaatattt acattttgct     2940



aacctagttt gttactttaa aaatcagttt tgatgaaagg agggaaaagc agatggactt     3000



gaaaaagatc caagctccta ttagaaaagg tatgaaaatc tttatagtaa aattttttat     3060



aaactaaagt tgtacctttt aatatgtagt aaactctcat ttatttgggg ttcgctcttg     3120



gatctcatcc atccattgtg ttctctttaa tgctgcctgc cttttgaggc attcactgcc     3180



ctagacaatg ccaccagaga tagtggggga aatgccagat gaaaccaact cttgctctca     3240



ctagttgtca gcttctctgg ataagtgacc acagaagcag gagtcctcct gcttgggcat     3300



cattgggcca gttccttctc tttaaatcag atttgtaatg gctcccaaat tccatcacat     3360



cacatttaaa ttgcagacag tgttttgcac atcatgtatc tgttttgtcc cataatatgc     3420



tttttactcc ctgatcccag tttctgctgt tgactcttcc attcagtttt atttattgtg     3480



tgttctcaca gtgacaccat ttgtcctttt ctgcaacaac ctttccagct acttttgcca     3540



aattctattt gtcttctcct tcaaaacatt ctcctttgca gttcctcttc atctgtgtag     3600



ctgctctttt gtctcttaac ttaccattcc tatagtactt tatgcatctc tgcttagttc     3660



tattagtttt ttggccttgc tcttctcctt gattttaaaa ttccttctat agctagagct     3720



tttctttctt tcattctctc ttcctgcagt gttttgcata catcagaagc taggtacata     3780



agttaaatga ttgagagttg gctgtattta gatttatcac tttttaatag ggtgagcttg     3840



agagttttct ttctttctgt tttttttttt tgtttttttt tttttttttt tttttttttt     3900



ttttgactaa tttcacatgc tctaaaaacc ttcaaaggtg attatttttc tcctggaaac     3960



tccaggtcca ttctgtttaa atccctaaga atgtcagaat taaaataaca gggctatccc     4020



gtaattggaa atatttcttt tttcaggatg ctatagtcaa tttagtaagt gaccaccaaa     4080



ttgttatttg cactaacaaa gctcaaaaca cgataagttt actcctccat ctcagtaata     4140



aaaattaagc tgtaatcaac cttctaggtt tctcttgtct taaaatgggt attcaaaaat     4200



ggggatctgt ggtgtatgta tggaaacaca tactccttaa tttacctgtt gttggaaact     4260



ggagaaatga ttgtcgggca accgtttatt ttttattgta ttttatttgg ttgagggatt     4320



tttttataaa cagttttact tgtgtcatat tttaaaatta ctaactgcca tcacctgctg     4380



gggtcctttg ttaggtcatt ttcagtgact aatagggata atccaggtaa ctttgaagag     4440



atgagcagtg agtgaccagg cagtttttct gcctttagct ttgacagttc ttaattaaga     4500



tcattgaaga ccagctttct cataaatttc tctttttgaa aaaaagaaag catttgtact     4560



aagctcctct gtaagacaac atcttaaatc ttaaaagtgt tgttatcatg actggtgaga     4620



gaagaaaaca ttttgttttt attaaatgga gcattattta caaaaagcca ttgttgagaa     4680



ttagatccca catcgtataa atatctatta accattctaa ataaagagaa ctccagtgtt     4740



gctatgtgca agatcctctc ttggagcttt tttgcatagc aattaaaggt gtgctatttg     4800



tcagtagcca tttttttgca gtgatttgaa gaccaaagtt gttttacagc tgtgttaccg     4860



ttaaaggttt ttttttttat atgtattaaa tcaatttatc actgtttaaa gctttgaata     4920



tctgcaatct ttgccaaggt acttttttat ttaaaaaaaa acataacttt gtaaatatta     4980



ccctgtaata ttatatatac ttaataaaac attttaagct a                         5021





<210> 10

<211> 293

<212> PRT

<213> Homo sapiens



<400> 10

Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 

1               5                   10                  15      





Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 

            20                  25                  30          





Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 

        35                  40                  45              





Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 

    50                  55                  60                  





Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 

65                  70                  75                  80  





Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 

                85                  90                  95      





Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 

            100                 105                 110         





Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 

        115                 120                 125             





Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 

    130                 135                 140                 





Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 

145                 150                 155                 160 





Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 

                165                 170                 175     





Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 

            180                 185                 190         





Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 

        195                 200                 205             





Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 

    210                 215                 220                 





Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 

225                 230                 235                 240 





Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 

                245                 250                 255     





Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 

            260                 265                 270         





Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 

        275                 280                 285             





Met Lys Phe Val Glu 

    290             





<210> 11

<211> 5288

<212> DNA

<213> Homo sapiens



<400> 11

ggggagcagg cgggggagcg ggcgggaagc agtgggagcg cgcgtgcgcg cggccgtgca       60



gcctgggcag tgggtcctgc ctgtgacgcg cggcggcggt cggtcctgcc tgtaacggcg      120



gcggcggctg ctgctccaga cacctgcggc ggcggcggcg accccgcggc gggcgcggag      180



atgtggcccc tggtagcggc gctgttgctg ggctcggcgt gctgcggatc agctcagcta      240



ctatttaata aaacaaaatc tgtagaattc acgttttgta atgacactgt cgtcattcca      300



tgctttgtta ctaatatgga ggcacaaaac actactgaag tatacgtaaa gtggaaattt      360



aaaggaagag atatttacac ctttgatgga gctctaaaca agtccactgt ccccactgac      420



tttagtagtg caaaaattga agtctcacaa ttactaaaag gagatgcctc tttgaagatg      480



gataagagtg atgctgtctc acacacagga aactacactt gtgaagtaac agaattaacc      540



agagaaggtg aaacgatcat cgagctaaaa tatcgtgttg tttcatggtt ttctccaaat      600



gaaaatattc ttattgttat tttcccaatt tttgctatac tcctgttctg gggacagttt      660



ggtattaaaa cacttaaata tagatccggt ggtatggatg agaaaacaat tgctttactt      720



gttgctggac tagtgatcac tgtcattgtc attgttggag ccattctttt cgtcccaggt      780



gaatattcat taaagaatgc tactggcctt ggtttaattg tgacttctac agggatatta      840



atattacttc actactatgt gtttagtaca gcgattggat taacctcctt cgtcattgcc      900



atattggtta ttcaggtgat agcctatatc ctcgctgtgg ttggactgag tctctgtatt      960



gcggcgtgta taccaatgca tggccctctt ctgatttcag gtttgagtat cttagctcta     1020



gcacaattac ttggactagt ttatatgaaa tttgtggctt ccaatcagaa gactatacaa     1080



cctcctagga ataactgaag tgaagtgatg gactccgatt tggagagtag taagacgtga     1140



aaggaataca cttgtgttta agcaccatgg ccttgatgat tcactgttgg ggagaagaaa     1200



caagaaaagt aactggttgt cacctatgag acccttacgt gattgttagt taagttttta     1260



ttcaaagcag ctgtaattta gttaataaaa taattatgat ctatgttgtt tgcccaattg     1320



agatccagtt ttttgttgtt atttttaatc aattaggggc aatagtagaa tggacaattt     1380



ccaagaatga tgcctttcag gtcctagggc ctctggcctc taggtaacca gtttaaattg     1440



gttcagggtg ataactactt agcactgccc tggtgattac ccagagatat ctatgaaaac     1500



cagtggcttc catcaaacct ttgccaactc aggttcacag cagctttggg cagttatggc     1560



agtatggcat tagctgagag gtgtctgcca cttctgggtc aatggaataa taaattaagt     1620



acaggcagga atttggttgg gagcatcttg tatgatctcc gtatgatgtg atattgatgg     1680



agatagtggt cctcattctt gggggttgcc attcccacat tcccccttca acaaacagtg     1740



taacaggtcc ttcccagatt tagggtactt ttattgatgg atatgttttc cttttattca     1800



cataacccct tgaaaccctg tcttgtcctc ctgttacttg cttctgctgt acaagatgta     1860



gcaccttttc tcctctttga acatggtcta gtgacacggt agcaccagtt gcaggaagga     1920



gccagacttg ttctcagagc actgtgttca cacttttcag caaaaatagc tatggttgta     1980



acatatgtat tcccttcctc tgatttgaag gcaaaaatct acagtgtttc ttcacttctt     2040



ttctgatctg gggcatgaaa aaagcaagat tgaaatttga actatgagtc tcctgcatgg     2100



caacaaaatg tgtgtcacca tcaggccaac aggccagccc ttgaatgggg atttattact     2160



gttgtatcta tgttgcatga taaacattca tcaccttcct cctgtagtcc tgcctcgtac     2220



tccccttccc ctatgattga aaagtaaaca aaacccacat ttcctatcct ggttagaaga     2280



aaattaatgt tctgacagtt gtgatcgcct ggagtacttt tagactttta gcattcgttt     2340



tttacctgtt tgtggatgtg tgtttgtatg tgcatacgta tgagataggc acatgcatct     2400



tctgtatgga caaaggtggg gtacctacag gagagcaaag gttaattttg tgcttttagt     2460



aaaaacattt aaatacaaag ttctttattg ggtggaatta tatttgatgc aaatatttga     2520



tcacttaaaa cttttaaaac ttctaggtaa tttgccacgc tttttgactg ctcaccaata     2580



ccctgtaaaa atacgtaatt cttcctgttt gtgtaataag atattcatat ttgtagttgc     2640



attaataata gttatttctt agtccatcag atgttcccgt gtgcctcttt tatgccaaat     2700



tgattgtcat atttcatgtt gggaccaagt agtttgccca tggcaaacct aaatttatga     2760



cctgctgagg cctctcagaa aactgagcat actagcaaga cagctcttct tgaaaaaaaa     2820



aatatgtata cacaaatata tacgtatatc tatatatacg tatgtatata cacacatgta     2880



tattcttcct tgattgtgta gctgtccaaa ataataacat atatagaggg agctgtattc     2940



ctttatacaa atctgatggc tcctgcagca ctttttcctt ctgaaaatat ttacattttg     3000



ctaacctagt ttgttacttt aaaaatcagt tttgatgaaa ggagggaaaa gcagatggac     3060



ttgaaaaaga tccaagctcc tattagaaaa ggtatgaaaa tctttatagt aaaatttttt     3120



ataaactaaa gttgtacctt ttaatatgta gtaaactctc atttatttgg ggttcgctct     3180



tggatctcat ccatccattg tgttctcttt aatgctgcct gccttttgag gcattcactg     3240



ccctagacaa tgccaccaga gatagtgggg gaaatgccag atgaaaccaa ctcttgctct     3300



cactagttgt cagcttctct ggataagtga ccacagaagc aggagtcctc ctgcttgggc     3360



atcattgggc cagttccttc tctttaaatc agatttgtaa tggctcccaa attccatcac     3420



atcacattta aattgcagac agtgttttgc acatcatgta tctgttttgt cccataatat     3480



gctttttact ccctgatccc agtttctgct gttgactctt ccattcagtt ttatttattg     3540



tgtgttctca cagtgacacc atttgtcctt ttctgcaaca acctttccag ctacttttgc     3600



caaattctat ttgtcttctc cttcaaaaca ttctcctttg cagttcctct tcatctgtgt     3660



agctgctctt ttgtctctta acttaccatt cctatagtac tttatgcatc tctgcttagt     3720



tctattagtt ttttggcctt gctcttctcc ttgattttaa aattccttct atagctagag     3780



cttttctttc tttcattctc tcttcctgca gtgttttgca tacatcagaa gctaggtaca     3840



taagttaaat gattgagagt tggctgtatt tagatttatc actttttaat agggtgagct     3900



tgagagtttt ctttctttct gttttttttt tttgtttttt tttttttttt tttttttttt     3960



ttttttgact aatttcacat gctctaaaaa ccttcaaagg tgattatttt tctcctggaa     4020



actccaggtc cattctgttt aaatccctaa gaatgtcaga attaaaataa cagggctatc     4080



ccgtaattgg aaatatttct tttttcagga tgctatagtc aatttagtaa gtgaccacca     4140



aattgttatt tgcactaaca aagctcaaaa cacgataagt ttactcctcc atctcagtaa     4200



taaaaattaa gctgtaatca accttctagg tttctcttgt cttaaaatgg gtattcaaaa     4260



atggggatct gtggtgtatg tatggaaaca catactcctt aatttacctg ttgttggaaa     4320



ctggagaaat gattgtcggg caaccgttta ttttttattg tattttattt ggttgaggga     4380



tttttttata aacagtttta cttgtgtcat attttaaaat tactaactgc catcacctgc     4440



tggggtcctt tgttaggtca ttttcagtga ctaataggga taatccaggt aactttgaag     4500



agatgagcag tgagtgacca ggcagttttt ctgcctttag ctttgacagt tcttaattaa     4560



gatcattgaa gaccagcttt ctcataaatt tctctttttg aaaaaaagaa agcatttgta     4620



ctaagctcct ctgtaagaca acatcttaaa tcttaaaagt gttgttatca tgactggtga     4680



gagaagaaaa cattttgttt ttattaaatg gagcattatt tacaaaaagc cattgttgag     4740



aattagatcc cacatcgtat aaatatctat taaccattct aaataaagag aactccagtg     4800



ttgctatgtg caagatcctc tcttggagct tttttgcata gcaattaaag gtgtgctatt     4860



tgtcagtagc catttttttg cagtgatttg aagaccaaag ttgttttaca gctgtgttac     4920



cgttaaaggt tttttttttt atatgtatta aatcaattta tcactgttta aagctttgaa     4980



tatctgcaat ctttgccaag gtactttttt atttaaaaaa aaacataact ttgtaaatat     5040



taccctgtaa tattatatat acttaataaa acattttaag ctattttgtt gggctatttc     5100



tattgctgct acagcagacc acaagcacat ttctgaaaaa tttaatttat taatgtattt     5160



ttaagttgct tatattctag gtaacaatgt aaagaatgat ttaaaatatt aattatgaat     5220



tttttgagta taatacccaa taagctttta attagagcag agttttaatt aaaagtttta     5280



aatcagtc                                                              5288





<210> 12

<211> 305

<212> PRT

<213> Homo sapiens



<400> 12

Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 

1               5                   10                  15      





Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 

            20                  25                  30          





Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 

        35                  40                  45              





Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 

    50                  55                  60                  





Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 

65                  70                  75                  80  





Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 

                85                  90                  95      





Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 

            100                 105                 110         





Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 

        115                 120                 125             





Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 

    130                 135                 140                 





Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 

145                 150                 155                 160 





Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 

                165                 170                 175     





Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 

            180                 185                 190         





Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 

        195                 200                 205             





Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 

    210                 215                 220                 





Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 

225                 230                 235                 240 





Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 

                245                 250                 255     





Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 

            260                 265                 270         





Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 

        275                 280                 285             





Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Asn 

    290                 295                 300                 





Asn 

305 





<210> 13

<211> 5078

<212> DNA

<213> Homo sapiens



<400> 13

agtgggagcg cgcgtgcgcg cggccgtgca gcctgggcag tgggtcctgc ctgtgacgcg       60



cggcggcggt cggtcctgcc tgtaacggcg gcggcggctg ctgctccgga cacctgcggc      120



ggcggcggcg accccgcggc gggcgcggag atgtggcccc tggtagcggc gctgttgctg      180



ggctcggcgt gctgcggatc agctcagcta ctatttaata aaacaaaatc tgtagaattc      240



acgttttgta atgacactgt cgtcattcca tgctttgtta ctaatatgga ggcacaaaac      300



actactgaag tatacgtaaa gtggaaattt aaaggaagag atatttacac ctttgatgga      360



gctctaaaca agtccactgt ccccactgac tttagtagtg caaaaattga agtctcacaa      420



ttactaaaag gagatgcctc tttgaagatg gataagagtg atgctgtctc acacacagga      480



aactacactt gtgaagtaac agaattaacc agagaaggtg aaacgatcat cgagctaaaa      540



tatcgtgttg tttcatggtt ttctccaaat gaaaatattc ttattgttat tttcccaatt      600



tttgctatac tcctgttctg gggacagttt ggtattaaaa cacttaaata tagatccggt      660



ggtatggatg agaaaacaat tgctttactt gttgctggac tagtgatcac tgtcattgtc      720



attgttggag ccattctttt cgtcccaggt gaatattcat taaagaatgc tactggcctt      780



ggtttaattg tgacttctac agggatatta atattacttc actactatgt gtttagtaca      840



gcgattggat taacctcctt cgtcattgcc atattggtta ttcaggtgat agcctatatc      900



ctcgctgtgg ttggactgag tctctgtatt gcggcgtgta taccaatgca tggccctctt      960



ctgatttcag gtttgagtat cttagctcta gcacaattac ttggactagt ttatatgaaa     1020



tttgtggctt ccaatcagaa gactatacaa cctcctagga aagctgtaga ggaacccctt     1080



aatgaataac tgaagtgaag tgatggactc cgatttggag agtagtaaga cgtgaaagga     1140



atacacttgt gtttaagcac catggccttg atgattcact gttggggaga agaaacaaga     1200



aaagtaactg gttgtcacct atgagaccct tacgtgattg ttagttaagt ttttattcaa     1260



agcagctgta atttagttaa taaaataatt atgatctatg ttgtttgccc aattgagatc     1320



cagttttttg ttgttatttt taatcaatta ggggcaatag tagaatggac aatttccaag     1380



aatgatgcct ttcaggtcct agggcctctg gcctctaggt aaccagttta aattggttca     1440



gggtgataac tacttagcac tgccctggtg attacccaga gatatctatg aaaaccagtg     1500



gcttccatca aacctttgcc aactcaggtt cacagcagct ttgggcagtt atggcagtat     1560



ggcattagct gagaggtgtc tgccacttct gggtcaatgg aataataaat taagtacagg     1620



caggaatttg gttgggagca tcttgtatga tctccgtatg atgtgatatt gatggagata     1680



gtggtcctca ttcttggggg ttgccattcc cacattcccc cttcaacaaa cagtgtaaca     1740



ggtccttccc agatttaggg tacttttatt gatggatatg ttttcctttt attcacataa     1800



ccccttgaaa ccctgtcttg tcctcctgtt acttgcttct gctgtacaag atgtagcacc     1860



ttttctcctc tttgaacatg gtctagtgac acggtagcac cagttgcagg aaggagccag     1920



acttgttctc agagcactgt gttcacactt ttcagcaaaa atagctatgg ttgtaacata     1980



tgtattccct tcctctgatt tgaaggcaaa aatctacagt gtttcttcac ttcttttctg     2040



atctggggca tgaaaaaagc aagattgaaa tttgaactat gagtctcctg catggcaaca     2100



aaatgtgtgt caccatcagg ccaacaggcc agcccttgaa tggggattta ttactgttgt     2160



atctatgttg catgataaac attcatcacc ttcctcctgt agtcctgcct cgtactcccc     2220



ttcccctatg attgaaaagt aaacaaaacc cacatttcct atcctggtta gaagaaaatt     2280



aatgttctga cagttgtgat cgcctggagt acttttagac ttttagcatt cgttttttac     2340



ctgtttgtgg atgtgtgttt gtatgtgcat acgtatgaga taggcacatg catcttctgt     2400



atggacaaag gtggggtacc tacaggagag caaaggttaa ttttgtgctt ttagtaaaaa     2460



catttaaata caaagttctt tattgggtgg aattatattt gatgcaaata tttgatcact     2520



taaaactttt aaaacttcta ggtaatttgc cacgcttttt gactgctcac caataccctg     2580



taaaaatacg taattcttcc tgtttgtgta ataagatatt catatttgta gttgcattaa     2640



taatagttat ttcttagtcc atcagatgtt cccgtgtgcc tcttttatgc caaattgatt     2700



gtcatatttc atgttgggac caagtagttt gcccatggca aacctaaatt tatgacctgc     2760



tgaggcctct cagaaaactg agcatactag caagacagct cttcttgaaa aaaaaaatat     2820



gtatacacaa atatatacgt atatctatat atacgtatgt atatacacac atgtatattc     2880



ttccttgatt gtgtagctgt ccaaaataat aacatatata gagggagctg tattccttta     2940



tacaaatctg atggctcctg cagcactttt tccttctgaa aatatttaca ttttgctaac     3000



ctagtttgtt actttaaaaa tcagttttga tgaaaggagg gaaaagcaga tggacttgaa     3060



aaagatccaa gctcctatta gaaaaggtat gaaaatcttt atagtaaaat tttttataaa     3120



ctaaagttgt accttttaat atgtagtaaa ctctcattta tttggggttc gctcttggat     3180



ctcatccatc cattgtgttc tctttaatgc tgcctgcctt ttgaggcatt cactgcccta     3240



gacaatgcca ccagagatag tgggggaaat gccagatgaa accaactctt gctctcacta     3300



gttgtcagct tctctggata agtgaccaca gaagcaggag tcctcctgct tgggcatcat     3360



tgggccagtt ccttctcttt aaatcagatt tgtaatggct cccaaattcc atcacatcac     3420



atttaaattg cagacagtgt tttgcacatc atgtatctgt tttgtcccat aatatgcttt     3480



ttactccctg atcccagttt ctgctgttga ctcttccatt cagttttatt tattgtgtgt     3540



tctcacagtg acaccatttg tccttttctg caacaacctt tccagctact tttgccaaat     3600



tctatttgtc ttctccttca aaacattctc ctttgcagtt cctcttcatc tgtgtagctg     3660



ctcttttgtc tcttaactta ccattcctat agtactttat gcatctctgc ttagttctat     3720



tagttttttg gccttgctct tctccttgat tttaaaattc cttctatagc tagagctttt     3780



ctttctttca ttctctcttc ctgcagtgtt ttgcatacat cagaagctag gtacataagt     3840



taaatgattg agagttggct gtatttagat ttatcacttt ttaatagggt gagcttgaga     3900



gttttctttc tttctgtttt ttttttttgt tttttttttt tttttttttt tttttttttt     3960



tgactaattt cacatgctct aaaaaccttc aaaggtgatt atttttctcc tggaaactcc     4020



aggtccattc tgtttaaatc cctaagaatg tcagaattaa aataacaggg ctatcccgta     4080



attggaaata tttctttttt caggatgcta tagtcaattt agtaagtgac caccaaattg     4140



ttatttgcac taacaaagct caaaacacga taagtttact cctccatctc agtaataaaa     4200



attaagctgt aatcaacctt ctaggtttct cttgtcttaa aatgggtatt caaaaatggg     4260



gatctgtggt gtatgtatgg aaacacatac tccttaattt acctgttgtt ggaaactgga     4320



gaaatgattg tcgggcaacc gtttattttt tattgtattt tatttggttg agggattttt     4380



ttataaacag ttttacttgt gtcatatttt aaaattacta actgccatca cctgctgggg     4440



tcctttgtta ggtcattttc agtgactaat agggataatc caggtaactt tgaagagatg     4500



agcagtgagt gaccaggcag tttttctgcc tttagctttg acagttctta attaagatca     4560



ttgaagacca gctttctcat aaatttctct ttttgaaaaa aagaaagcat ttgtactaag     4620



ctcctctgta agacaacatc ttaaatctta aaagtgttgt tatcatgact ggtgagagaa     4680



gaaaacattt tgtttttatt aaatggagca ttatttacaa aaagccattg ttgagaatta     4740



gatcccacat cgtataaata tctattaacc attctaaata aagagaactc cagtgttgct     4800



atgtgcaaga tcctctcttg gagctttttt gcatagcaat taaaggtgtg ctatttgtca     4860



gtagccattt ttttgcagtg atttgaagac caaagttgtt ttacagctgt gttaccgtta     4920



aaggtttttt tttttatatg tattaaatca atttatcact gtttaaagct ttgaatatct     4980



gcaatctttg ccaaggtact tttttattta aaaaaaaaca taactttgta aatattaccc     5040



tgtaatatta tatatactta ataaaacatt ttaagcta                             5078





<210> 14

<211> 312

<212> PRT

<213> Homo sapiens



<400> 14

Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 

1               5                   10                  15      





Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 

            20                  25                  30          





Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 

        35                  40                  45              





Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 

    50                  55                  60                  





Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 

65                  70                  75                  80  





Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 

                85                  90                  95      





Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 

            100                 105                 110         





Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 

        115                 120                 125             





Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 

    130                 135                 140                 





Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 

145                 150                 155                 160 





Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 

                165                 170                 175     





Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 

            180                 185                 190         





Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 

        195                 200                 205             





Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 

    210                 215                 220                 





Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 

225                 230                 235                 240 





Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 

                245                 250                 255     





Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 

            260                 265                 270         





Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 

        275                 280                 285             





Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 

    290                 295                 300                 





Ala Val Glu Glu Pro Leu Asn Glu 

305                 310         





<210> 15

<211> 5346

<212> DNA

<213> Homo sapiens



<400> 15

ggggagcagg cgggggagcg ggcgggaagc agtgggagcg cgcgtgcgcg cggccgtgca       60



gcctgggcag tgggtcctgc ctgtgacgcg cggcggcggt cggtcctgcc tgtaacggcg      120



gcggcggctg ctgctccaga cacctgcggc ggcggcggcg accccgcggc gggcgcggag      180



atgtggcccc tggtagcggc gctgttgctg ggctcggcgt gctgcggatc agctcagcta      240



ctatttaata aaacaaaatc tgtagaattc acgttttgta atgacactgt cgtcattcca      300



tgctttgtta ctaatatgga ggcacaaaac actactgaag tatacgtaaa gtggaaattt      360



aaaggaagag atatttacac ctttgatgga gctctaaaca agtccactgt ccccactgac      420



tttagtagtg caaaaattga agtctcacaa ttactaaaag gagatgcctc tttgaagatg      480



gataagagtg atgctgtctc acacacagga aactacactt gtgaagtaac agaattaacc      540



agagaaggtg aaacgatcat cgagctaaaa tatcgtgttg tttcatggtt ttctccaaat      600



gaaaatattc ttattgttat tttcccaatt tttgctatac tcctgttctg gggacagttt      660



ggtattaaaa cacttaaata tagatccggt ggtatggatg agaaaacaat tgctttactt      720



gttgctggac tagtgatcac tgtcattgtc attgttggag ccattctttt cgtcccaggt      780



gaatattcat taaagaatgc tactggcctt ggtttaattg tgacttctac agggatatta      840



atattacttc actactatgt gtttagtaca gcgattggat taacctcctt cgtcattgcc      900



atattggtta ttcaggtgat agcctatatc ctcgctgtgg ttggactgag tctctgtatt      960



gcggcgtgta taccaatgca tggccctctt ctgatttcag gtttgagtat cttagctcta     1020



gcacaattac ttggactagt ttatatgaaa tttgtggctt ccaatcagaa gactatacaa     1080



cctcctagga aagctgtaga ggaacccctt aatgcattca aagaatcaaa aggaatgatg     1140



aatgatgaat aactgaagtg aagtgatgga ctccgatttg gagagtagta agacgtgaaa     1200



ggaatacact tgtgtttaag caccatggcc ttgatgattc actgttgggg agaagaaaca     1260



agaaaagtaa ctggttgtca cctatgagac ccttacgtga ttgttagtta agtttttatt     1320



caaagcagct gtaatttagt taataaaata attatgatct atgttgtttg cccaattgag     1380



atccagtttt ttgttgttat ttttaatcaa ttaggggcaa tagtagaatg gacaatttcc     1440



aagaatgatg cctttcaggt cctagggcct ctggcctcta ggtaaccagt ttaaattggt     1500



tcagggtgat aactacttag cactgccctg gtgattaccc agagatatct atgaaaacca     1560



gtggcttcca tcaaaccttt gccaactcag gttcacagca gctttgggca gttatggcag     1620



tatggcatta gctgagaggt gtctgccact tctgggtcaa tggaataata aattaagtac     1680



aggcaggaat ttggttggga gcatcttgta tgatctccgt atgatgtgat attgatggag     1740



atagtggtcc tcattcttgg gggttgccat tcccacattc ccccttcaac aaacagtgta     1800



acaggtcctt cccagattta gggtactttt attgatggat atgttttcct tttattcaca     1860



taaccccttg aaaccctgtc ttgtcctcct gttacttgct tctgctgtac aagatgtagc     1920



accttttctc ctctttgaac atggtctagt gacacggtag caccagttgc aggaaggagc     1980



cagacttgtt ctcagagcac tgtgttcaca cttttcagca aaaatagcta tggttgtaac     2040



atatgtattc ccttcctctg atttgaaggc aaaaatctac agtgtttctt cacttctttt     2100



ctgatctggg gcatgaaaaa agcaagattg aaatttgaac tatgagtctc ctgcatggca     2160



acaaaatgtg tgtcaccatc aggccaacag gccagccctt gaatggggat ttattactgt     2220



tgtatctatg ttgcatgata aacattcatc accttcctcc tgtagtcctg cctcgtactc     2280



cccttcccct atgattgaaa agtaaacaaa acccacattt cctatcctgg ttagaagaaa     2340



attaatgttc tgacagttgt gatcgcctgg agtactttta gacttttagc attcgttttt     2400



tacctgtttg tggatgtgtg tttgtatgtg catacgtatg agataggcac atgcatcttc     2460



tgtatggaca aaggtggggt acctacagga gagcaaaggt taattttgtg cttttagtaa     2520



aaacatttaa atacaaagtt ctttattggg tggaattata tttgatgcaa atatttgatc     2580



acttaaaact tttaaaactt ctaggtaatt tgccacgctt tttgactgct caccaatacc     2640



ctgtaaaaat acgtaattct tcctgtttgt gtaataagat attcatattt gtagttgcat     2700



taataatagt tatttcttag tccatcagat gttcccgtgt gcctctttta tgccaaattg     2760



attgtcatat ttcatgttgg gaccaagtag tttgcccatg gcaaacctaa atttatgacc     2820



tgctgaggcc tctcagaaaa ctgagcatac tagcaagaca gctcttcttg aaaaaaaaaa     2880



tatgtataca caaatatata cgtatatcta tatatacgta tgtatataca cacatgtata     2940



ttcttccttg attgtgtagc tgtccaaaat aataacatat atagagggag ctgtattcct     3000



ttatacaaat ctgatggctc ctgcagcact ttttccttct gaaaatattt acattttgct     3060



aacctagttt gttactttaa aaatcagttt tgatgaaagg agggaaaagc agatggactt     3120



gaaaaagatc caagctccta ttagaaaagg tatgaaaatc tttatagtaa aattttttat     3180



aaactaaagt tgtacctttt aatatgtagt aaactctcat ttatttgggg ttcgctcttg     3240



gatctcatcc atccattgtg ttctctttaa tgctgcctgc cttttgaggc attcactgcc     3300



ctagacaatg ccaccagaga tagtggggga aatgccagat gaaaccaact cttgctctca     3360



ctagttgtca gcttctctgg ataagtgacc acagaagcag gagtcctcct gcttgggcat     3420



cattgggcca gttccttctc tttaaatcag atttgtaatg gctcccaaat tccatcacat     3480



cacatttaaa ttgcagacag tgttttgcac atcatgtatc tgttttgtcc cataatatgc     3540



tttttactcc ctgatcccag tttctgctgt tgactcttcc attcagtttt atttattgtg     3600



tgttctcaca gtgacaccat ttgtcctttt ctgcaacaac ctttccagct acttttgcca     3660



aattctattt gtcttctcct tcaaaacatt ctcctttgca gttcctcttc atctgtgtag     3720



ctgctctttt gtctcttaac ttaccattcc tatagtactt tatgcatctc tgcttagttc     3780



tattagtttt ttggccttgc tcttctcctt gattttaaaa ttccttctat agctagagct     3840



tttctttctt tcattctctc ttcctgcagt gttttgcata catcagaagc taggtacata     3900



agttaaatga ttgagagttg gctgtattta gatttatcac tttttaatag ggtgagcttg     3960



agagttttct ttctttctgt tttttttttt tgtttttttt tttttttttt tttttttttt     4020



ttttgactaa tttcacatgc tctaaaaacc ttcaaaggtg attatttttc tcctggaaac     4080



tccaggtcca ttctgtttaa atccctaaga atgtcagaat taaaataaca gggctatccc     4140



gtaattggaa atatttcttt tttcaggatg ctatagtcaa tttagtaagt gaccaccaaa     4200



ttgttatttg cactaacaaa gctcaaaaca cgataagttt actcctccat ctcagtaata     4260



aaaattaagc tgtaatcaac cttctaggtt tctcttgtct taaaatgggt attcaaaaat     4320



ggggatctgt ggtgtatgta tggaaacaca tactccttaa tttacctgtt gttggaaact     4380



ggagaaatga ttgtcgggca accgtttatt ttttattgta ttttatttgg ttgagggatt     4440



tttttataaa cagttttact tgtgtcatat tttaaaatta ctaactgcca tcacctgctg     4500



gggtcctttg ttaggtcatt ttcagtgact aatagggata atccaggtaa ctttgaagag     4560



atgagcagtg agtgaccagg cagtttttct gcctttagct ttgacagttc ttaattaaga     4620



tcattgaaga ccagctttct cataaatttc tctttttgaa aaaaagaaag catttgtact     4680



aagctcctct gtaagacaac atcttaaatc ttaaaagtgt tgttatcatg actggtgaga     4740



gaagaaaaca ttttgttttt attaaatgga gcattattta caaaaagcca ttgttgagaa     4800



ttagatccca catcgtataa atatctatta accattctaa ataaagagaa ctccagtgtt     4860



gctatgtgca agatcctctc ttggagcttt tttgcatagc aattaaaggt gtgctatttg     4920



tcagtagcca tttttttgca gtgatttgaa gaccaaagtt gttttacagc tgtgttaccg     4980



ttaaaggttt ttttttttat atgtattaaa tcaatttatc actgtttaaa gctttgaata     5040



tctgcaatct ttgccaaggt acttttttat ttaaaaaaaa acataacttt gtaaatatta     5100



ccctgtaata ttatatatac ttaataaaac attttaagct attttgttgg gctatttcta     5160



ttgctgctac agcagaccac aagcacattt ctgaaaaatt taatttatta atgtattttt     5220



aagttgctta tattctaggt aacaatgtaa agaatgattt aaaatattaa ttatgaattt     5280



tttgagtata atacccaata agcttttaat tagagcagag ttttaattaa aagttttaaa     5340



tcagtc                                                                5346





<210> 16

<211> 323

<212> PRT

<213> Homo sapiens



<400> 16

Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 

1               5                   10                  15      





Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 

            20                  25                  30          





Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 

        35                  40                  45              





Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 

    50                  55                  60                  





Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 

65                  70                  75                  80  





Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 

                85                  90                  95      





Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 

            100                 105                 110         





Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 

        115                 120                 125             





Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 

    130                 135                 140                 





Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 

145                 150                 155                 160 





Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 

                165                 170                 175     





Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 

            180                 185                 190         





Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 

        195                 200                 205             





Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 

    210                 215                 220                 





Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 

225                 230                 235                 240 





Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 

                245                 250                 255     





Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 

            260                 265                 270         





Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 

        275                 280                 285             





Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 

    290                 295                 300                 





Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met 

305                 310                 315                 320 





Asn Asp Glu 

            





<210> 17

<211> 293

<212> PRT

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      polypeptide"



<400> 17

Met Trp Pro Leu Ala Ala Ala Leu Leu Leu Gly Ser Cys Cys Cys Gly 

1               5                   10                  15      





Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 

            20                  25                  30          





Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 

        35                  40                  45              





Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 

    50                  55                  60                  





Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 

65                  70                  75                  80  





Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 

                85                  90                  95      





Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 

            100                 105                 110         





Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 

        115                 120                 125             





Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 

    130                 135                 140                 





Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 

145                 150                 155                 160 





Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 

                165                 170                 175     





Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 

            180                 185                 190         





Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 

        195                 200                 205             





Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 

    210                 215                 220                 





Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 

225                 230                 235                 240 





Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 

                245                 250                 255     





Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 

            260                 265                 270         





Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 

        275                 280                 285             





Met Lys Phe Val Glu 

    290             





<210> 18

<211> 305

<212> PRT

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      polypeptide"



<400> 18

Met Trp Pro Leu Ala Ala Ala Leu Leu Leu Gly Ser Cys Cys Cys Gly 

1               5                   10                  15      





Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 

            20                  25                  30          





Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 

        35                  40                  45              





Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 

    50                  55                  60                  





Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 

65                  70                  75                  80  





Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 

                85                  90                  95      





Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 

            100                 105                 110         





Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 

        115                 120                 125             





Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 

    130                 135                 140                 





Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 

145                 150                 155                 160 





Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 

                165                 170                 175     





Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 

            180                 185                 190         





Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 

        195                 200                 205             





Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 

    210                 215                 220                 





Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 

225                 230                 235                 240 





Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 

                245                 250                 255     





Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 

            260                 265                 270         





Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 

        275                 280                 285             





Met Lys Phe Val Ala Ser Asn Gln Arg Thr Ile Gln Pro Pro Arg Asn 

    290                 295                 300                 





Arg 

305 





<210> 19

<211> 312

<212> PRT

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      polypeptide"



<400> 19

Met Trp Pro Leu Ala Ala Ala Leu Leu Leu Gly Ser Cys Cys Cys Gly 

1               5                   10                  15      





Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 

            20                  25                  30          





Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 

        35                  40                  45              





Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 

    50                  55                  60                  





Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 

65                  70                  75                  80  





Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 

                85                  90                  95      





Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 

            100                 105                 110         





Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 

        115                 120                 125             





Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 

    130                 135                 140                 





Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 

145                 150                 155                 160 





Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 

                165                 170                 175     





Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 

            180                 185                 190         





Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 

        195                 200                 205             





Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 

    210                 215                 220                 





Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 

225                 230                 235                 240 





Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 

                245                 250                 255     





Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 

            260                 265                 270         





Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 

        275                 280                 285             





Met Lys Phe Val Ala Ser Asn Gln Arg Thr Ile Gln Pro Pro Arg Lys 

    290                 295                 300                 





Ala Val Glu Glu Pro Leu Asn Glu 

305                 310         





<210> 20

<211> 323

<212> PRT

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      polypeptide"



<400> 20

Met Trp Pro Leu Ala Ala Ala Leu Leu Leu Gly Ser Cys Cys Cys Gly 

1               5                   10                  15      





Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 

            20                  25                  30          





Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 

        35                  40                  45              





Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 

    50                  55                  60                  





Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 

65                  70                  75                  80  





Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 

                85                  90                  95      





Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 

            100                 105                 110         





Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 

        115                 120                 125             





Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 

    130                 135                 140                 





Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 

145                 150                 155                 160 





Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 

                165                 170                 175     





Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 

            180                 185                 190         





Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 

        195                 200                 205             





Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 

    210                 215                 220                 





Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 

225                 230                 235                 240 





Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 

                245                 250                 255     





Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 

            260                 265                 270         





Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 

        275                 280                 285             





Met Lys Phe Val Ala Ser Asn Gln Arg Thr Ile Gln Pro Pro Arg Lys 

    290                 295                 300                 





Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met 

305                 310                 315                 320 





Asn Asp Glu 

            





<210> 21

<211> 22

<212> DNA

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      primer"



<400> 21

tgcagaagtc actaggagga at                                                22





<210> 22

<211> 27

<212> DNA

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      probe"



<400> 22

tcagtcaact tcttctgggt tgtttcc                                           27





<210> 23

<211> 23

<212> DNA

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      primer"



<400> 23

gtgccagact cactttctat cca                                               23





<210> 24

<211> 22

<212> DNA

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      primer"



<400> 24

tgctgccaat atacggcttc tg                                                22





<210> 25

<211> 26

<212> DNA

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      probe"



<400> 25

cagctctcat agccaactat ggtgcc                                            26





<210> 26

<211> 22

<212> DNA

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      primer"



<400> 26

tcaagcagag cctggttatc tg                                                22





<210> 27

<211> 23

<212> DNA

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      primer"



<400> 27

gtcgtcattc catgctttgt tac                                               23





<210> 28

<211> 30

<212> DNA

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      probe"



<400> 28

tggaggcaca aaacactact gaagtatacg                                        30





<210> 29

<211> 22

<212> DNA

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      primer"



<400> 29

ggacagtgga cttgtttaga gc                                                22





<210> 30

<211> 21

<212> DNA

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      primer"



<400> 30

ggcttggtgg ctgattgttc t                                                 21





<210> 31

<211> 28

<212> DNA

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      probe"



<400> 31

agcacccaaa ctgatatgcc tgtatttg                                          28





<210> 32

<211> 23

<212> DNA

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      primer"



<400> 32

tgggaactgg tgtttcaagt cta                                               23





<210> 33

<211> 158

<212> DNA

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      polynucleotide"



<400> 33

gcagacatga ttacttcaga gctttcaaag ctagatactg taccttgcat attccaacac       60



gcgatcgcat tttaagattt tccatcctag tggaaagata tgatttgatt catcctattt      120



actttgtata ttaaagtaca gtagaacctg ccactttt                              158





<210> 34

<211> 160

<212> DNA

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      polynucleotide"



<400> 34

ggatccattt taagtaatag aataggattt ttaattgttc cagtgtttct gtgatagagc       60



tgtcctgcac agacctgttt ctcgagataa cttcgtataa tgtatgctat acgaagttat      120



atgcatggcc tccgcgccgg gttttggcgc ctcccgcggg                            160





<210> 35

<211> 160

<212> DNA

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      polynucleotide"



<400> 35

catgtctgga ataacttcgt ataatgtatg ctatacgaag ttatgctagt aactataacg       60



gtcctaaggt agcgactagc attagtatgg aaggtccgtc cactgtccag gttcctcttg      120



cggagctctt tgtctctctg gactctgtat acactgcttg                            160





<210> 36

<211> 239

<212> DNA

<213> Artificial Sequence



<220>

<221> source

<223> /note="Description of Artificial Sequence: Synthetic

      polynucleotide"



<400> 36

ggatccattt taagtaatag aataggattt ttaattgttc cagtgtttct gtgatagagc       60



tgtcctgcac agacctgttt ctcgagataa cttcgtataa tgtatgctat acgaagttat      120



gctagtaact ataacggtcc taaggtagcg actagcatta gtatggaagg tccgtccact      180



gtccaggttc ctcttgcgga gctctttgtc tctctggact ctgtatacac tgcttgcat       239





