                         SEQUENCE LISTING

<110>  Glenmark Pharmaceuticals S.A.
 
<120>  ANTI-TRKA ANTIBODIES WITH ENHANCED INHIBITORY PROPERTIES AND 
       DERIVATIVES THEREOF FOR USE IN TREATING BONE ASSOCIATED PAIN

<130>  PCT

<160>  116   

<170>  PatentIn version 3.3

<210>  1
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  VH1 domain

<400>  1

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  2
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  VH2 domain

<400>  2

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  3
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  VH3 domain

<400>  3

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  4
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  VH4 domain

<400>  4

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  5
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  VH5 domain

<400>  5

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  6
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  VL1 domain

<400>  6

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Thr Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  7
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  VL2 domain

<400>  7

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Thr Thr Ser Asn Leu Ala Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Asp Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  8
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  VL3 domain

<400>  8

Gln Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Thr Thr Ser Asn Leu Ala Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Phe Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  9
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  VL4 domain

<400>  9

Gln Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Thr Thr Ser Asn Leu Ala Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Asp Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  10
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  VL5 domain

<400>  10

Gln Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Thr Thr Ser Asn Leu Ala Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Asp Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  11
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  VL6 domain

<400>  11

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Glu Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Thr Thr Ser Asn Leu Ala Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Phe Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Asp Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  12
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  VL7 domain

<400>  12

Gln Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Thr Thr Ser Asn Leu Ala Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Phe Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Asp Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  13
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  VL8 domain

<400>  13

Gln Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Glu Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Thr Thr Ser Asn Leu Ala Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Phe Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Asp Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  14
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDR1 of the heavy chain variable domain

<400>  14

Gly Phe Thr Phe Ser Thr Tyr Thr Met Ser 
1               5                   10  


<210>  15
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDR2 of the heavy chain variable domain

<400>  15

Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  16
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  CDR3 of the heavy chain variable domain

<400>  16

Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
1               5                   10                  


<210>  17
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDR1 of the light chain variable domain

<400>  17

Ser Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  18
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CDR2 of the light chain variable domain

<400>  18

Thr Thr Ser Asn Leu Ala Ser 
1               5           


<210>  19
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CDR3 of the light chain variable domain

<400>  19

His Gln Trp Ser Ser Tyr Pro Trp Thr Phe 
1               5                   10  


<210>  20
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  MNAC13 VH domain

<400>  20

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Ala Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  21
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  MNAC13 heavy chain

<400>  21

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Ala Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Lys Thr Thr Pro Pro 
        115                 120                 125             


Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met 
    130                 135                 140                 


Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Glu Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val 
            180                 185                 190         


Pro Ser Ser Pro Arg Pro Ser Glu Thr Val Thr Cys Asn Val Ala His 
        195                 200                 205             


Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys 
    210                 215                 220                 


Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe 
225                 230                 235                 240 


Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro 
                245                 250                 255     


Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr 
        275                 280                 285             


Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu 
    290                 295                 300                 


Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys 
305                 310                 315                 320 


Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro 
            340                 345                 350         


Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile 
        355                 360                 365             


Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly 
    370                 375                 380                 


Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asn Thr Asn 
385                 390                 395                 400 


Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp 
                405                 410                 415     


Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His 
            420                 425                 430         


Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440                 445     


<210>  22
<211>  212
<212>  PRT
<213>  Artificial

<220>
<223>  MNAC13 light chain

<400>  22

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Glu Ile Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Thr Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Phe Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Asp Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Asp Ala Ala Pro Thr 
            100                 105                 110         


Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala 
        115                 120                 125             


Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val 
    130                 135                 140                 


Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser 
145                 150                 155                 160 


Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr 
                165                 170                 175     


Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys 
            180                 185                 190         


Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn 
        195                 200                 205             


Arg Asn Glu Cys 
    210         


<210>  23
<211>  98
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VH3-23*01 domain
<222>  (1)..(98)

<400>  23

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys 
        


<210>  24
<211>  628
<212>  PRT
<213>  Artificial

<220>
<223>  human TrkA-Fc fusion protein

<400>  24

Ala Ala Pro Cys Pro Asp Ala Cys Cys Pro His Gly Ser Ser Gly Leu 
1               5                   10                  15      


Arg Cys Thr Arg Asp Gly Ala Leu Asp Ser Leu His His Leu Pro Gly 
            20                  25                  30          


Ala Glu Asn Leu Thr Glu Leu Tyr Ile Glu Asn Gln Gln His Leu Gln 
        35                  40                  45              


His Leu Glu Leu Arg Asp Leu Arg Gly Leu Gly Glu Leu Arg Asn Leu 
    50                  55                  60                  


Thr Ile Val Lys Ser Gly Leu Arg Phe Val Ala Pro Asp Ala Phe His 
65                  70                  75                  80  


Phe Thr Pro Arg Leu Ser Arg Leu Asn Leu Ser Phe Asn Ala Leu Glu 
                85                  90                  95      


Ser Leu Ser Trp Lys Thr Val Gln Gly Leu Ser Leu Gln Glu Leu Val 
            100                 105                 110         


Leu Ser Gly Asn Pro Leu His Cys Ser Cys Ala Leu Arg Trp Leu Gln 
        115                 120                 125             


Arg Trp Glu Glu Glu Gly Leu Gly Gly Val Pro Glu Gln Lys Leu Gln 
    130                 135                 140                 


Cys His Gly Gln Gly Pro Leu Ala His Met Pro Asn Ala Ser Cys Gly 
145                 150                 155                 160 


Val Pro Thr Leu Lys Val Gln Val Pro Asn Ala Ser Val Asp Val Gly 
                165                 170                 175     


Asp Asp Val Leu Leu Arg Cys Gln Val Glu Gly Arg Gly Leu Glu Gln 
            180                 185                 190         


Ala Gly Trp Ile Leu Thr Glu Leu Glu Gln Ser Ala Thr Val Met Lys 
        195                 200                 205             


Ser Gly Gly Leu Pro Ser Leu Gly Leu Thr Leu Ala Asn Val Thr Ser 
    210                 215                 220                 


Asp Leu Asn Arg Lys Asn Val Thr Cys Trp Ala Glu Asn Asp Val Gly 
225                 230                 235                 240 


Arg Ala Glu Val Ser Val Gln Val Asn Val Ser Phe Pro Ala Ser Val 
                245                 250                 255     


Gln Leu His Thr Ala Val Glu Met His His Trp Cys Ile Pro Phe Ser 
            260                 265                 270         


Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser 
        275                 280                 285             


Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Ala 
    290                 295                 300                 


Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr 
305                 310                 315                 320 


His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Phe Gly 
                325                 330                 335     


Gln Ala Ser Ala Ser Ile Met Ala Ala Phe Met Asp Asn Pro Phe Glu 
            340                 345                 350         


Phe Asn Pro Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr 
        355                 360                 365             


Asn Ser Thr Ser Gly Asp Pro Val Glu Lys Lys Asp Glu Thr Pro Phe 
    370                 375                 380                 


Gly Val Ser Val Ala Val Gly Ala Ala Ala Glu Asn Leu Tyr Phe Gln 
385                 390                 395                 400 


Ser Gly Ser Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                405                 410                 415     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            420                 425                 430         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        435                 440                 445             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    450                 455                 460                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
465                 470                 475                 480 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                485                 490                 495     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            500                 505                 510         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        515                 520                 525             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    530                 535                 540                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
545                 550                 555                 560 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                565                 570                 575     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            580                 585                 590         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        595                 600                 605             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    610                 615                 620                 


Ser Pro Gly Lys 
625             


<210>  25
<211>  391
<212>  PRT
<213>  Homo sapiens


<220>
<221>  human TrkA extracellular region
<222>  (1)..(391)

<400>  25

Ala Ala Pro Cys Pro Asp Ala Cys Cys Pro His Gly Ser Ser Gly Leu 
1               5                   10                  15      


Arg Cys Thr Arg Asp Gly Ala Leu Asp Ser Leu His His Leu Pro Gly 
            20                  25                  30          


Ala Glu Asn Leu Thr Glu Leu Tyr Ile Glu Asn Gln Gln His Leu Gln 
        35                  40                  45              


His Leu Glu Leu Arg Asp Leu Arg Gly Leu Gly Glu Leu Arg Asn Leu 
    50                  55                  60                  


Thr Ile Val Lys Ser Gly Leu Arg Phe Val Ala Pro Asp Ala Phe His 
65                  70                  75                  80  


Phe Thr Pro Arg Leu Ser Arg Leu Asn Leu Ser Phe Asn Ala Leu Glu 
                85                  90                  95      


Ser Leu Ser Trp Lys Thr Val Gln Gly Leu Ser Leu Gln Glu Leu Val 
            100                 105                 110         


Leu Ser Gly Asn Pro Leu His Cys Ser Cys Ala Leu Arg Trp Leu Gln 
        115                 120                 125             


Arg Trp Glu Glu Glu Gly Leu Gly Gly Val Pro Glu Gln Lys Leu Gln 
    130                 135                 140                 


Cys His Gly Gln Gly Pro Leu Ala His Met Pro Asn Ala Ser Cys Gly 
145                 150                 155                 160 


Val Pro Thr Leu Lys Val Gln Val Pro Asn Ala Ser Val Asp Val Gly 
                165                 170                 175     


Asp Asp Val Leu Leu Arg Cys Gln Val Glu Gly Arg Gly Leu Glu Gln 
            180                 185                 190         


Ala Gly Trp Ile Leu Thr Glu Leu Glu Gln Ser Ala Thr Val Met Lys 
        195                 200                 205             


Ser Gly Gly Leu Pro Ser Leu Gly Leu Thr Leu Ala Asn Val Thr Ser 
    210                 215                 220                 


Asp Leu Asn Arg Lys Asn Val Thr Cys Trp Ala Glu Asn Asp Val Gly 
225                 230                 235                 240 


Arg Ala Glu Val Ser Val Gln Val Asn Val Ser Phe Pro Ala Ser Val 
                245                 250                 255     


Gln Leu His Thr Ala Val Glu Met His His Trp Cys Ile Pro Phe Ser 
            260                 265                 270         


Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser 
        275                 280                 285             


Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Ala 
    290                 295                 300                 


Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr 
305                 310                 315                 320 


His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Phe Gly 
                325                 330                 335     


Gln Ala Ser Ala Ser Ile Met Ala Ala Phe Met Asp Asn Pro Phe Glu 
            340                 345                 350         


Phe Asn Pro Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr 
        355                 360                 365             


Asn Ser Thr Ser Gly Asp Pro Val Glu Lys Lys Asp Glu Thr Pro Phe 
    370                 375                 380                 


Gly Val Ser Val Ala Val Gly 
385                 390     


<210>  26
<211>  453
<212>  PRT
<213>  Artificial

<220>
<223>  BXhVH1 heavy chain

<400>  26

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  27
<211>  453
<212>  PRT
<213>  Artificial

<220>
<223>  BXhVH3 heavy chain

<400>  27

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  28
<211>  453
<212>  PRT
<213>  Artificial

<220>
<223>  BXhVH5 heavy chain

<400>  28

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  29
<211>  213
<212>  PRT
<213>  Artificial

<220>
<223>  BXhVL1 light chain

<400>  29

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Thr Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  30
<211>  213
<212>  PRT
<213>  Artificial

<220>
<223>  BXhVL3 light chain

<400>  30

Gln Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Thr Thr Ser Asn Leu Ala Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Phe Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  31
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(K3Q) heavy chain variable domain

<400>  31

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  32
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(V37A) heavy chain variable domain

<400>  32

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Ala Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  33
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(G42E) heavy chain variable domain

<400>  33

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  34
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(V89L) heavy chain variable domain

<400>  34

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  35
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(R94K) heavy chain variable domain

<400>  35

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  36
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,V37A) heavy chain variable domain

<400>  36

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Ala Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  37
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,T40A)  heavy chain variable domain

<400>  37

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  38
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(P60A,T62S) heavy chain variable domain

<400>  38

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  39
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,V37A,R44G) heavy chain variable domain

<400>  39

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Ala Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  40
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,A49S,Y50A) heavy chain variable domain

<400>  40

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  41
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,P60A,T62S) heavy chain variable domain

<400>  41

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  42
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,T40A,P60A,T62S) heavy chain variable domain

<400>  42

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  43
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,V37A,T40A,P60A,T62S) heavy chain variable domain

<400>  43

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Ala Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  44
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,T40A,R44G,A49S,Y50A) heavy chain variable domain

<400>  44

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  45
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,A49S,Y50A,P60A,T62S) heavy chain variable domain

<400>  45

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  46
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,T40A,R44G,A49S,Y50A,P60A,T62S) heavy chain variable 
       domain

<400>  46

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  47
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,T40A,R44G,A49S,Y50A,P60A,T62S,R94K) heavy chain 
       variable domain

<400>  47

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  48
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH1(V37A) heavy chain variable domain

<400>  48

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  49
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH3(V37A) heavy chain  variable domain

<400>  49

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Ala Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  50
<211>  453
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(K3Q) heavy chain IGHG1

<400>  50

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  51
<211>  453
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(V37A) heavy chain IGHG1

<400>  51

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Ala Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  52
<211>  450
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(V37A) heavy chain IGHG4 S228P

<400>  52

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Ala Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        435                 440                 445             


Gly Lys 
    450 


<210>  53
<211>  453
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(G42E) heavy chain IGHG1

<400>  53

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  54
<211>  453
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(V89L) heavy chain IGHG1

<400>  54

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  55
<211>  453
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(R94K) heavy chain IGHG1

<400>  55

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  56
<211>  453
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,V37A) heavy chain IGHG1

<400>  56

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Ala Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  57
<211>  450
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,V37A) heavy chain IGHG4 S228P

<400>  57

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Ala Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        435                 440                 445             


Gly Lys 
    450 


<210>  58
<211>  453
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,T40A)  heavy chain IGHG1

<400>  58

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  59
<211>  453
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(P60A,T62S) heavy chain IGHG1

<400>  59

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  60
<211>  453
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,V37A,R44G) heavy chain IGHG1

<400>  60

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Ala Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  61
<211>  453
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,A49S,Y50A) heavy chain IGHG1

<400>  61

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  62
<211>  453
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,P60A,T62S) heavy chain IGHG1

<400>  62

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  63
<211>  453
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,T40A,P60A,T62S) heavy chain IGHG1

<400>  63

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  64
<211>  453
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,V37A,T40A,P60A,T62S) heavy chain IGHG1

<400>  64

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Ala Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  65
<211>  453
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,T40A,R44G,A49S,Y50A) heavy chain IGHG1

<400>  65

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  66
<211>  453
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,A49S,Y50A,P60A,T62S) heavy chain IGHG1

<400>  66

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  67
<211>  453
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,T40A,R44G,A49S,Y50A,P60A,T62S) heavy chain IGHG1

<400>  67

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  68
<211>  453
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,T40A,R44G,A49S,Y50A,P60A,T62S,R94K) heavy chain IGHG1

<400>  68

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  69
<211>  453
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH1(V37A) heavy chain IGHG1

<400>  69

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  70
<211>  453
<212>  PRT
<213>  Artificial

<220>
<223>  GBR VH3(V37A) heavy chain IGHG1

<400>  70

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Ala Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  71
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  VH domain of humanized MNAC13

<400>  71

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Tyr Gly Asn Asp Phe Phe Tyr Pro Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  72
<211>  796
<212>  PRT
<213>  Homo sapiens


<220>
<221>  human TrkA
<222>  (1)..(796)

<400>  72

Met Leu Arg Gly Gly Arg Arg Gly Gln Leu Gly Trp His Ser Trp Ala 
1               5                   10                  15      


Ala Gly Pro Gly Ser Leu Leu Ala Trp Leu Ile Leu Ala Ser Ala Gly 
            20                  25                  30          


Ala Ala Pro Cys Pro Asp Ala Cys Cys Pro His Gly Ser Ser Gly Leu 
        35                  40                  45              


Arg Cys Thr Arg Asp Gly Ala Leu Asp Ser Leu His His Leu Pro Gly 
    50                  55                  60                  


Ala Glu Asn Leu Thr Glu Leu Tyr Ile Glu Asn Gln Gln His Leu Gln 
65                  70                  75                  80  


His Leu Glu Leu Arg Asp Leu Arg Gly Leu Gly Glu Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Lys Ser Gly Leu Arg Phe Val Ala Pro Asp Ala Phe His 
            100                 105                 110         


Phe Thr Pro Arg Leu Ser Arg Leu Asn Leu Ser Phe Asn Ala Leu Glu 
        115                 120                 125             


Ser Leu Ser Trp Lys Thr Val Gln Gly Leu Ser Leu Gln Glu Leu Val 
    130                 135                 140                 


Leu Ser Gly Asn Pro Leu His Cys Ser Cys Ala Leu Arg Trp Leu Gln 
145                 150                 155                 160 


Arg Trp Glu Glu Glu Gly Leu Gly Gly Val Pro Glu Gln Lys Leu Gln 
                165                 170                 175     


Cys His Gly Gln Gly Pro Leu Ala His Met Pro Asn Ala Ser Cys Gly 
            180                 185                 190         


Val Pro Thr Leu Lys Val Gln Val Pro Asn Ala Ser Val Asp Val Gly 
        195                 200                 205             


Asp Asp Val Leu Leu Arg Cys Gln Val Glu Gly Arg Gly Leu Glu Gln 
    210                 215                 220                 


Ala Gly Trp Ile Leu Thr Glu Leu Glu Gln Ser Ala Thr Val Met Lys 
225                 230                 235                 240 


Ser Gly Gly Leu Pro Ser Leu Gly Leu Thr Leu Ala Asn Val Thr Ser 
                245                 250                 255     


Asp Leu Asn Arg Lys Asn Val Thr Cys Trp Ala Glu Asn Asp Val Gly 
            260                 265                 270         


Arg Ala Glu Val Ser Val Gln Val Asn Val Ser Phe Pro Ala Ser Val 
        275                 280                 285             


Gln Leu His Thr Ala Val Glu Met His His Trp Cys Ile Pro Phe Ser 
    290                 295                 300                 


Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser 
305                 310                 315                 320 


Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Ala 
                325                 330                 335     


Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr 
            340                 345                 350         


His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Phe Gly 
        355                 360                 365             


Gln Ala Ser Ala Ser Ile Met Ala Ala Phe Met Asp Asn Pro Phe Glu 
    370                 375                 380                 


Phe Asn Pro Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr 
385                 390                 395                 400 


Asn Ser Thr Ser Gly Asp Pro Val Glu Lys Lys Asp Glu Thr Pro Phe 
                405                 410                 415     


Gly Val Ser Val Ala Val Gly Leu Ala Val Phe Ala Cys Leu Phe Leu 
            420                 425                 430         


Ser Thr Leu Leu Leu Val Leu Asn Lys Cys Gly Arg Arg Asn Lys Phe 
        435                 440                 445             


Gly Ile Asn Arg Pro Ala Val Leu Ala Pro Glu Asp Gly Leu Ala Met 
    450                 455                 460                 


Ser Leu His Phe Met Thr Leu Gly Gly Ser Ser Leu Ser Pro Thr Glu 
465                 470                 475                 480 


Gly Lys Gly Ser Gly Leu Gln Gly His Ile Ile Glu Asn Pro Gln Tyr 
                485                 490                 495     


Phe Ser Asp Ala Cys Val His His Ile Lys Arg Arg Asp Ile Val Leu 
            500                 505                 510         


Lys Trp Glu Leu Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu 
        515                 520                 525             


Cys His Asn Leu Leu Pro Glu Gln Asp Lys Met Leu Val Ala Val Lys 
    530                 535                 540                 


Ala Leu Lys Glu Ala Ser Glu Ser Ala Arg Gln Asp Phe Gln Arg Glu 
545                 550                 555                 560 


Ala Glu Leu Leu Thr Met Leu Gln His Gln His Ile Val Arg Phe Phe 
                565                 570                 575     


Gly Val Cys Thr Glu Gly Arg Pro Leu Leu Met Val Phe Glu Tyr Met 
            580                 585                 590         


Arg His Gly Asp Leu Asn Arg Phe Leu Arg Ser His Gly Pro Asp Ala 
        595                 600                 605             


Lys Leu Leu Ala Gly Gly Glu Asp Val Ala Pro Gly Pro Leu Gly Leu 
    610                 615                 620                 


Gly Gln Leu Leu Ala Val Ala Ser Gln Val Ala Ala Gly Met Val Tyr 
625                 630                 635                 640 


Leu Ala Gly Leu His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys 
                645                 650                 655     


Leu Val Gly Gln Gly Leu Val Val Lys Ile Gly Asp Phe Gly Met Ser 
            660                 665                 670         


Arg Asp Ile Tyr Ser Thr Asp Tyr Tyr Arg Val Gly Gly Arg Thr Met 
        675                 680                 685             


Leu Pro Ile Arg Trp Met Pro Pro Glu Ser Ile Leu Tyr Arg Lys Phe 
    690                 695                 700                 


Thr Thr Glu Ser Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu Ile 
705                 710                 715                 720 


Phe Thr Tyr Gly Lys Gln Pro Trp Tyr Gln Leu Ser Asn Thr Glu Ala 
                725                 730                 735     


Ile Asp Cys Ile Thr Gln Gly Arg Glu Leu Glu Arg Pro Arg Ala Cys 
            740                 745                 750         


Pro Pro Glu Val Tyr Ala Ile Met Arg Gly Cys Trp Gln Arg Glu Pro 
        755                 760                 765             


Gln Gln Arg His Ser Ile Lys Asp Val His Ala Arg Leu Gln Ala Leu 
    770                 775                 780                 


Ala Gln Ala Pro Pro Val Tyr Leu Asp Val Leu Gly 
785                 790                 795     


<210>  73
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(K3Q) heavy chain variable domain cDNA

<400>  73
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggt ccgacagacc    120

cccggcaagc ggctggaatg ggtggcctac atcagcaagg gcggaggcag cacctactac    180

cccgacaccg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagc                                                            369


<210>  74
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(V37A) heavy chain variable domain cDNA

<400>  74
gaagtgaaac tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggc ccgacagacc    120

cccggcaagc ggctggaatg ggtggcctac atcagcaagg gcggaggcag cacctactac    180

cccgacaccg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagc                                                            369


<210>  75
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(G42E) heavy chain variable domain cDNA

<400>  75
gaagtgaaac tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggt ccgacagacc    120

cccgaaaagc ggctggaatg ggtggcctac atcagcaagg gcggaggcag cacctactac    180

cccgacaccg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagc                                                            369


<210>  76
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(V89L) heavy chain variable domain cDNA

<400>  76
gaagtgaaac tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggt ccgacagacc    120

cccggcaagc ggctggaatg ggtggcctac atcagcaagg gcggaggcag cacctactac    180

cccgacaccg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccctgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagc                                                            369


<210>  77
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(R94K) heavy chain variable domain cDNA

<400>  77
gaagtgaaac tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggt ccgacagacc    120

cccggcaagc ggctggaatg ggtggcctac atcagcaagg gcggaggcag cacctactac    180

cccgacaccg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc caagggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagc                                                            369


<210>  78
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,V37A) heavy chain variable domain cDNA

<400>  78
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggc ccgacagacc    120

cccggcaagc ggctggaatg ggtggcctac atcagcaagg gcggaggcag cacctactac    180

cccgacaccg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagc                                                            369


<210>  79
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,T40A)  heavy chain variable domain cDNA

<400>  79
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggt ccgacaggcc    120

cccggcaagc ggctggaatg ggtggcctac atcagcaagg gcggaggcag cacctactac    180

cccgacaccg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagc                                                            369


<210>  80
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(P60A,T62S) heavy chain variable domain cDNA

<400>  80
gaagtgaaac tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggt ccgacagacc    120

cccggcaagc ggctggaatg ggtggcctac atcagcaagg gcggaggcag cacctactac    180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagc                                                            369


<210>  81
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,V37A,R44G) heavy chain variable domain cDNA

<400>  81
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggc ccgacagacc    120

cccggcaagg ggctggaatg ggtggcctac atcagcaagg gcggaggcag cacctactac    180

cccgacaccg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagc                                                            369


<210>  82
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,A49S,Y50A) heavy chain variable domain cDNA

<400>  82
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggt ccgacagacc    120

cccggcaagc ggctggaatg ggtgagcgcc atcagcaagg gcggaggcag cacctactac    180

cccgacaccg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagc                                                            369


<210>  83
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,P60A,T62S) heavy chain variable domain cDNA

<400>  83
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggt ccgacagacc    120

cccggcaagc ggctggaatg ggtggcctac atcagcaagg gcggaggcag cacctactac    180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagc                                                            369


<210>  84
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,T40A,P60A,T62S) heavy chain variable domain cDNA

<400>  84
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggt ccgacaggcc    120

cccggcaagc ggctggaatg ggtggcctac atcagcaagg gcggaggcag cacctactac    180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagc                                                            369


<210>  85
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,V37A,T40A,P60A,T62S) heavy chain variable domain cDNA

<400>  85
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggc ccgacaggcc    120

cccggcaagc ggctggaatg ggtggcctac atcagcaagg gcggaggcag cacctactac    180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagc                                                            369


<210>  86
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,T40A,R44G,A49S,Y50A) heavy chain variable domain cDNA

<400>  86
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggt ccgacaggcc    120

cccggcaagg gcctggaatg ggtgagcgcc atcagcaagg gcggaggcag cacctactac    180

cccgacaccg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagc                                                            369


<210>  87
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,A49S,Y50A,P60A,T62S) heavy chain variable domain cDNA

<400>  87
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggt ccgacagacc    120

cccggcaagc ggctggaatg ggtgagcgcc atcagcaagg gcggaggcag cacctactac    180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagc                                                            369


<210>  88
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,T40A,R44G,A49S,Y50A,P60A,T62S) heavy chain variable 
       domain cDNA

<400>  88
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggt ccgacaggcc    120

cccggcaagg gcctggaatg ggtgagcgcc atcagcaagg gcggaggcag cacctactac    180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagc                                                            369


<210>  89
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,T40A,R44G,A49S,Y50A,P60A,T62S,R94K) heavy chain 
       variable domain cDNA

<400>  89
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggt ccgacaggcc    120

cccggcaagg gcctggaatg ggtgagcgcc atcagcaagg gcggaggcag cacctactac    180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc caagggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagc                                                            369


<210>  90
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH1(V37A) heavy chain variable domain cDNA

<400>  90
gaagtgcagc tgctggaaag cggcggaggg ctggtgcagc caggcggcag cctgaggctg     60

tcctgcgccg ccagcggctt caccttcagc acctacacca tgagctgggc ccgacaggcc    120

ccaggcaagg gcctggaatg ggtgtcctac atcagcaagg gcggaggaag cacctactac    180

cccgacaccg tgaagggcag gttcaccatc agcagggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgag ggccgaggac accgccgtgt actactgcgc caagggcgcc    300

atgtacggca acgacttttt ctaccccatg gactactggg ggcagggcac caccgtgacc    360

gtgtctagc                                                            369


<210>  91
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH3(V37A) heavy chain  variable domain cDNA

<400>  91
gaagtgcagc tgctggaaag cggcggaggg ctggtgcagc caggcggcag cctgaggctg     60

tcctgcgccg ccagcggctt caccttcagc acctacacca tgagctgggc ccgacagacc    120

cccggcaaga ggctggaatg ggtggcctac atcagcaagg gcggaggaag cacctactac    180

cccgacaccg tgaagggcag gttcaccatc agcagggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgag ggccgaggac accgccgtgt actactgcgc caagggcgcc    300

atgtacggca acgacttttt ctaccccatg gactactggg ggcagggcac caccgtgacc    360

gtgtctagc                                                            369


<210>  92
<211>  1359
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(K3Q) heavy chain IGHG1 cDNA

<400>  92
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggt ccgacagacc    120

cccggcaagc ggctggaatg ggtggcctac atcagcaagg gcggaggcag cacctactac    180

cccgacaccg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagcg cgtcgaccaa gggccccagc gtgttcccgc tagcccccag cagcaagagc    420

accagcggcg gcacagccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg    480

accgtgtcct ggaactctgg agccctgacc tccggcgtgc acaccttccc cgccgtgctc    540

cagagcagcg gcctgtacag cctgagcagc gtggtgacag tgcccagcag cagcctggga    600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag    660

gtggagccca agagctgcga caagacccac acctgccccc cctgccctgc ccctgagctg    720

ctgggcggac cctccgtgtt cctgttcccc cccaagccca aggacaccct gatgatcagc    780

cggacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc tgaggtgaag    840

ttcaattggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc ccgggaggaa    900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg    960

aacggcaagg aatacaagtg caaggtctcc aacaaggccc tgcctgcccc catcgaaaag   1020

accatcagca aggccaaggg ccagcccagg gagccccagg tgtacaccct gcccccctcc   1080

cgggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tggtgaaggg cttctacccc   1140

agcgacatcg ccgtggagtg ggagagcaac ggccagcccg agaacaacta caagaccacc   1200

ccccctgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag   1260

agccggtggc agcagggcaa cgtgttcagc tgctccgtga tgcacgaggc cctgcacaac   1320

cactacaccc agaagagcct gagcctgtcc cccggcaag                          1359


<210>  93
<211>  1359
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(V37A) heavy chain IGHG1 cDNA

<400>  93
gaagtgaaac tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggc ccgacagacc    120

cccggcaagc ggctggaatg ggtggcctac atcagcaagg gcggaggcag cacctactac    180

cccgacaccg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagcg cgtcgaccaa gggccccagc gtgttcccgc tagcccccag cagcaagagc    420

accagcggcg gcacagccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg    480

accgtgtcct ggaactctgg agccctgacc tccggcgtgc acaccttccc cgccgtgctc    540

cagagcagcg gcctgtacag cctgagcagc gtggtgacag tgcccagcag cagcctggga    600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag    660

gtggagccca agagctgcga caagacccac acctgccccc cctgccctgc ccctgagctg    720

ctgggcggac cctccgtgtt cctgttcccc cccaagccca aggacaccct gatgatcagc    780

cggacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc tgaggtgaag    840

ttcaattggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc ccgggaggaa    900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg    960

aacggcaagg aatacaagtg caaggtctcc aacaaggccc tgcctgcccc catcgaaaag   1020

accatcagca aggccaaggg ccagcccagg gagccccagg tgtacaccct gcccccctcc   1080

cgggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tggtgaaggg cttctacccc   1140

agcgacatcg ccgtggagtg ggagagcaac ggccagcccg agaacaacta caagaccacc   1200

ccccctgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag   1260

agccggtggc agcagggcaa cgtgttcagc tgctccgtga tgcacgaggc cctgcacaac   1320

cactacaccc agaagagcct gagcctgtcc cccggcaag                          1359


<210>  94
<211>  1350
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(V37A) heavy chain IGHG4 S228P cDNA

<400>  94
gaagtgaaac tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggc ccgacagacc    120

cccggcaagc ggctggaatg ggtggcctac atcagcaagg gcggaggcag cacctactac    180

cccgacaccg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagcg cgtcgaccaa gggccccagc gtgttccccc tggccccctg cagcagaagc    420

accagcgagt ccacagccgc cctgggctgt ctggtgaagg actacttccc cgagcccgtg    480

accgtgtcct ggaacagcgg agccctgacc agcggcgtgc acaccttccc cgccgtgctg    540

cagagcagcg gcctgtacag cctgagcagc gtggtgacag tgcccagcag cagcctgggc    600

accaagacct acacctgcaa cgtggaccac aagcccagca acaccaaggt ggacaagagg    660

gtggagagca agtacggccc accctgcccc ccatgcccag cccccgagtt cctgggcgga    720

ccctccgtgt tcctgttccc ccccaagccc aaggacaccc tgatgatcag caggaccccc    780

gaggtgacct gcgtggtggt ggacgtgagc caggaggacc cagaggtcca gttcaactgg    840

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc ccagagagga gcagtttaac    900

agcacctaca gggtggtgtc cgtgctgacc gtgctgcacc aggactggct gaacggcaag    960

gaatacaagt gcaaggtctc caacaagggc ctgcccagct ccatcgagaa aaccatcagc   1020

aaggccaagg gccagccacg ggagccccag gtgtacaccc tgccaccctc ccaggaggag   1080

atgaccaaga accaggtgtc cctgacctgc ctggtgaagg gcttctaccc cagcgacatc   1140

gccgtggagt gggagagcaa cggccagccc gagaacaact acaagaccac ccccccagtg   1200

ctggacagcg acggcagctt cttcctgtac agcaggctga ccgtggacaa gtccaggtgg   1260

caggagggca acgtctttag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc   1320

cagaagagcc tgagcctgtc cctgggcaag                                    1350


<210>  95
<211>  1359
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(G42E) heavy chain IGHG1 cDNA

<400>  95
gaagtgaaac tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggt ccgacagacc    120

cccgaaaagc ggctggaatg ggtggcctac atcagcaagg gcggaggcag cacctactac    180

cccgacaccg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagcg cgtcgaccaa gggccccagc gtgttcccgc tagcccccag cagcaagagc    420

accagcggcg gcacagccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg    480

accgtgtcct ggaactctgg agccctgacc tccggcgtgc acaccttccc cgccgtgctc    540

cagagcagcg gcctgtacag cctgagcagc gtggtgacag tgcccagcag cagcctggga    600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag    660

gtggagccca agagctgcga caagacccac acctgccccc cctgccctgc ccctgagctg    720

ctgggcggac cctccgtgtt cctgttcccc cccaagccca aggacaccct gatgatcagc    780

cggacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc tgaggtgaag    840

ttcaattggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc ccgggaggaa    900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg    960

aacggcaagg aatacaagtg caaggtctcc aacaaggccc tgcctgcccc catcgaaaag   1020

accatcagca aggccaaggg ccagcccagg gagccccagg tgtacaccct gcccccctcc   1080

cgggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tggtgaaggg cttctacccc   1140

agcgacatcg ccgtggagtg ggagagcaac ggccagcccg agaacaacta caagaccacc   1200

ccccctgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag   1260

agccggtggc agcagggcaa cgtgttcagc tgctccgtga tgcacgaggc cctgcacaac   1320

cactacaccc agaagagcct gagcctgtcc cccggcaag                          1359


<210>  96
<211>  1359
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(V89L) heavy chain IGHG1 cDNA

<400>  96
gaagtgaaac tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggt ccgacagacc    120

cccggcaagc ggctggaatg ggtggcctac atcagcaagg gcggaggcag cacctactac    180

cccgacaccg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccctgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagcg cgtcgaccaa gggccccagc gtgttcccgc tagcccccag cagcaagagc    420

accagcggcg gcacagccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg    480

accgtgtcct ggaactctgg agccctgacc tccggcgtgc acaccttccc cgccgtgctc    540

cagagcagcg gcctgtacag cctgagcagc gtggtgacag tgcccagcag cagcctggga    600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag    660

gtggagccca agagctgcga caagacccac acctgccccc cctgccctgc ccctgagctg    720

ctgggcggac cctccgtgtt cctgttcccc cccaagccca aggacaccct gatgatcagc    780

cggacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc tgaggtgaag    840

ttcaattggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc ccgggaggaa    900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg    960

aacggcaagg aatacaagtg caaggtctcc aacaaggccc tgcctgcccc catcgaaaag   1020

accatcagca aggccaaggg ccagcccagg gagccccagg tgtacaccct gcccccctcc   1080

cgggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tggtgaaggg cttctacccc   1140

agcgacatcg ccgtggagtg ggagagcaac ggccagcccg agaacaacta caagaccacc   1200

ccccctgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag   1260

agccggtggc agcagggcaa cgtgttcagc tgctccgtga tgcacgaggc cctgcacaac   1320

cactacaccc agaagagcct gagcctgtcc cccggcaag                          1359


<210>  97
<211>  1359
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(R94K) heavy chain IGHG1 cDNA

<400>  97
gaagtgaaac tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggt ccgacagacc    120

cccggcaagc ggctggaatg ggtggcctac atcagcaagg gcggaggcag cacctactac    180

cccgacaccg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc caagggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagcg cgtcgaccaa gggccccagc gtgttcccgc tagcccccag cagcaagagc    420

accagcggcg gcacagccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg    480

accgtgtcct ggaactctgg agccctgacc tccggcgtgc acaccttccc cgccgtgctc    540

cagagcagcg gcctgtacag cctgagcagc gtggtgacag tgcccagcag cagcctggga    600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag    660

gtggagccca agagctgcga caagacccac acctgccccc cctgccctgc ccctgagctg    720

ctgggcggac cctccgtgtt cctgttcccc cccaagccca aggacaccct gatgatcagc    780

cggacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc tgaggtgaag    840

ttcaattggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc ccgggaggaa    900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg    960

aacggcaagg aatacaagtg caaggtctcc aacaaggccc tgcctgcccc catcgaaaag   1020

accatcagca aggccaaggg ccagcccagg gagccccagg tgtacaccct gcccccctcc   1080

cgggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tggtgaaggg cttctacccc   1140

agcgacatcg ccgtggagtg ggagagcaac ggccagcccg agaacaacta caagaccacc   1200

ccccctgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag   1260

agccggtggc agcagggcaa cgtgttcagc tgctccgtga tgcacgaggc cctgcacaac   1320

cactacaccc agaagagcct gagcctgtcc cccggcaag                          1359


<210>  98
<211>  1359
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,V37A) heavy chain IGHG1 cDNA

<400>  98
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggc ccgacagacc    120

cccggcaagc ggctggaatg ggtggcctac atcagcaagg gcggaggcag cacctactac    180

cccgacaccg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagcg cgtcgaccaa gggccccagc gtgttcccgc tagcccccag cagcaagagc    420

accagcggcg gcacagccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg    480

accgtgtcct ggaactctgg agccctgacc tccggcgtgc acaccttccc cgccgtgctc    540

cagagcagcg gcctgtacag cctgagcagc gtggtgacag tgcccagcag cagcctggga    600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag    660

gtggagccca agagctgcga caagacccac acctgccccc cctgccctgc ccctgagctg    720

ctgggcggac cctccgtgtt cctgttcccc cccaagccca aggacaccct gatgatcagc    780

cggacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc tgaggtgaag    840

ttcaattggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc ccgggaggaa    900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg    960

aacggcaagg aatacaagtg caaggtctcc aacaaggccc tgcctgcccc catcgaaaag   1020

accatcagca aggccaaggg ccagcccagg gagccccagg tgtacaccct gcccccctcc   1080

cgggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tggtgaaggg cttctacccc   1140

agcgacatcg ccgtggagtg ggagagcaac ggccagcccg agaacaacta caagaccacc   1200

ccccctgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag   1260

agccggtggc agcagggcaa cgtgttcagc tgctccgtga tgcacgaggc cctgcacaac   1320

cactacaccc agaagagcct gagcctgtcc cccggcaag                          1359


<210>  99
<211>  1350
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,V37A) heavy chain IGHG4 S228P cDNA

<400>  99
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggc ccgacagacc    120

cccggcaagc ggctggaatg ggtggcctac atcagcaagg gcggaggcag cacctactac    180

cccgacaccg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagcg cgtcgaccaa gggccccagc gtgttccccc tggccccctg cagcagaagc    420

accagcgagt ccacagccgc cctgggctgt ctggtgaagg actacttccc cgagcccgtg    480

accgtgtcct ggaacagcgg agccctgacc agcggcgtgc acaccttccc cgccgtgctg    540

cagagcagcg gcctgtacag cctgagcagc gtggtgacag tgcccagcag cagcctgggc    600

accaagacct acacctgcaa cgtggaccac aagcccagca acaccaaggt ggacaagagg    660

gtggagagca agtacggccc accctgcccc ccatgcccag cccccgagtt cctgggcgga    720

ccctccgtgt tcctgttccc ccccaagccc aaggacaccc tgatgatcag caggaccccc    780

gaggtgacct gcgtggtggt ggacgtgagc caggaggacc cagaggtcca gttcaactgg    840

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc ccagagagga gcagtttaac    900

agcacctaca gggtggtgtc cgtgctgacc gtgctgcacc aggactggct gaacggcaag    960

gaatacaagt gcaaggtctc caacaagggc ctgcccagct ccatcgagaa aaccatcagc   1020

aaggccaagg gccagccacg ggagccccag gtgtacaccc tgccaccctc ccaggaggag   1080

atgaccaaga accaggtgtc cctgacctgc ctggtgaagg gcttctaccc cagcgacatc   1140

gccgtggagt gggagagcaa cggccagccc gagaacaact acaagaccac ccccccagtg   1200

ctggacagcg acggcagctt cttcctgtac agcaggctga ccgtggacaa gtccaggtgg   1260

caggagggca acgtctttag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc   1320

cagaagagcc tgagcctgtc cctgggcaag                                    1350


<210>  100
<211>  1359
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,T40A)  heavy chain IGHG1 cDNA

<400>  100
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggt ccgacaggcc    120

cccggcaagc ggctggaatg ggtggcctac atcagcaagg gcggaggcag cacctactac    180

cccgacaccg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagcg cgtcgaccaa gggccccagc gtgttcccgc tagcccccag cagcaagagc    420

accagcggcg gcacagccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg    480

accgtgtcct ggaactctgg agccctgacc tccggcgtgc acaccttccc cgccgtgctc    540

cagagcagcg gcctgtacag cctgagcagc gtggtgacag tgcccagcag cagcctggga    600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag    660

gtggagccca agagctgcga caagacccac acctgccccc cctgccctgc ccctgagctg    720

ctgggcggac cctccgtgtt cctgttcccc cccaagccca aggacaccct gatgatcagc    780

cggacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc tgaggtgaag    840

ttcaattggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc ccgggaggaa    900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg    960

aacggcaagg aatacaagtg caaggtctcc aacaaggccc tgcctgcccc catcgaaaag   1020

accatcagca aggccaaggg ccagcccagg gagccccagg tgtacaccct gcccccctcc   1080

cgggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tggtgaaggg cttctacccc   1140

agcgacatcg ccgtggagtg ggagagcaac ggccagcccg agaacaacta caagaccacc   1200

ccccctgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag   1260

agccggtggc agcagggcaa cgtgttcagc tgctccgtga tgcacgaggc cctgcacaac   1320

cactacaccc agaagagcct gagcctgtcc cccggcaag                          1359


<210>  101
<211>  1359
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(P60A,T62S) heavy chain IGHG1 cDNA

<400>  101
gaagtgaaac tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggt ccgacagacc    120

cccggcaagc ggctggaatg ggtggcctac atcagcaagg gcggaggcag cacctactac    180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagcg cgtcgaccaa gggccccagc gtgttcccgc tagcccccag cagcaagagc    420

accagcggcg gcacagccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg    480

accgtgtcct ggaactctgg agccctgacc tccggcgtgc acaccttccc cgccgtgctc    540

cagagcagcg gcctgtacag cctgagcagc gtggtgacag tgcccagcag cagcctggga    600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag    660

gtggagccca agagctgcga caagacccac acctgccccc cctgccctgc ccctgagctg    720

ctgggcggac cctccgtgtt cctgttcccc cccaagccca aggacaccct gatgatcagc    780

cggacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc tgaggtgaag    840

ttcaattggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc ccgggaggaa    900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg    960

aacggcaagg aatacaagtg caaggtctcc aacaaggccc tgcctgcccc catcgaaaag   1020

accatcagca aggccaaggg ccagcccagg gagccccagg tgtacaccct gcccccctcc   1080

cgggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tggtgaaggg cttctacccc   1140

agcgacatcg ccgtggagtg ggagagcaac ggccagcccg agaacaacta caagaccacc   1200

ccccctgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag   1260

agccggtggc agcagggcaa cgtgttcagc tgctccgtga tgcacgaggc cctgcacaac   1320

cactacaccc agaagagcct gagcctgtcc cccggcaag                          1359


<210>  102
<211>  1359
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,V37A,R44G) heavy chain IGHG1 cDNA

<400>  102
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggc ccgacagacc    120

cccggcaagg ggctggaatg ggtggcctac atcagcaagg gcggaggcag cacctactac    180

cccgacaccg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagcg cgtcgaccaa gggccccagc gtgttcccgc tagcccccag cagcaagagc    420

accagcggcg gcacagccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg    480

accgtgtcct ggaactctgg agccctgacc tccggcgtgc acaccttccc cgccgtgctc    540

cagagcagcg gcctgtacag cctgagcagc gtggtgacag tgcccagcag cagcctggga    600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag    660

gtggagccca agagctgcga caagacccac acctgccccc cctgccctgc ccctgagctg    720

ctgggcggac cctccgtgtt cctgttcccc cccaagccca aggacaccct gatgatcagc    780

cggacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc tgaggtgaag    840

ttcaattggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc ccgggaggaa    900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg    960

aacggcaagg aatacaagtg caaggtctcc aacaaggccc tgcctgcccc catcgaaaag   1020

accatcagca aggccaaggg ccagcccagg gagccccagg tgtacaccct gcccccctcc   1080

cgggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tggtgaaggg cttctacccc   1140

agcgacatcg ccgtggagtg ggagagcaac ggccagcccg agaacaacta caagaccacc   1200

ccccctgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag   1260

agccggtggc agcagggcaa cgtgttcagc tgctccgtga tgcacgaggc cctgcacaac   1320

cactacaccc agaagagcct gagcctgtcc cccggcaag                          1359


<210>  103
<211>  1359
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,A49S,Y50A) heavy chain IGHG1 cDNA

<400>  103
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggt ccgacagacc    120

cccggcaagc ggctggaatg ggtgagcgcc atcagcaagg gcggaggcag cacctactac    180

cccgacaccg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagcg cgtcgaccaa gggccccagc gtgttcccgc tagcccccag cagcaagagc    420

accagcggcg gcacagccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg    480

accgtgtcct ggaactctgg agccctgacc tccggcgtgc acaccttccc cgccgtgctc    540

cagagcagcg gcctgtacag cctgagcagc gtggtgacag tgcccagcag cagcctggga    600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag    660

gtggagccca agagctgcga caagacccac acctgccccc cctgccctgc ccctgagctg    720

ctgggcggac cctccgtgtt cctgttcccc cccaagccca aggacaccct gatgatcagc    780

cggacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc tgaggtgaag    840

ttcaattggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc ccgggaggaa    900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg    960

aacggcaagg aatacaagtg caaggtctcc aacaaggccc tgcctgcccc catcgaaaag   1020

accatcagca aggccaaggg ccagcccagg gagccccagg tgtacaccct gcccccctcc   1080

cgggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tggtgaaggg cttctacccc   1140

agcgacatcg ccgtggagtg ggagagcaac ggccagcccg agaacaacta caagaccacc   1200

ccccctgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag   1260

agccggtggc agcagggcaa cgtgttcagc tgctccgtga tgcacgaggc cctgcacaac   1320

cactacaccc agaagagcct gagcctgtcc cccggcaag                          1359


<210>  104
<211>  1359
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,P60A,T62S) heavy chain IGHG1 cDNA

<400>  104
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggt ccgacagacc    120

cccggcaagc ggctggaatg ggtggcctac atcagcaagg gcggaggcag cacctactac    180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagcg cgtcgaccaa gggccccagc gtgttcccgc tagcccccag cagcaagagc    420

accagcggcg gcacagccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg    480

accgtgtcct ggaactctgg agccctgacc tccggcgtgc acaccttccc cgccgtgctc    540

cagagcagcg gcctgtacag cctgagcagc gtggtgacag tgcccagcag cagcctggga    600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag    660

gtggagccca agagctgcga caagacccac acctgccccc cctgccctgc ccctgagctg    720

ctgggcggac cctccgtgtt cctgttcccc cccaagccca aggacaccct gatgatcagc    780

cggacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc tgaggtgaag    840

ttcaattggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc ccgggaggaa    900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg    960

aacggcaagg aatacaagtg caaggtctcc aacaaggccc tgcctgcccc catcgaaaag   1020

accatcagca aggccaaggg ccagcccagg gagccccagg tgtacaccct gcccccctcc   1080

cgggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tggtgaaggg cttctacccc   1140

agcgacatcg ccgtggagtg ggagagcaac ggccagcccg agaacaacta caagaccacc   1200

ccccctgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag   1260

agccggtggc agcagggcaa cgtgttcagc tgctccgtga tgcacgaggc cctgcacaac   1320

cactacaccc agaagagcct gagcctgtcc cccggcaag                          1359


<210>  105
<211>  1359
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,T40A,P60A,T62S) heavy chain IGHG1 cDNA

<400>  105
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggt ccgacaggcc    120

cccggcaagc ggctggaatg ggtggcctac atcagcaagg gcggaggcag cacctactac    180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagcg cgtcgaccaa gggccccagc gtgttcccgc tagcccccag cagcaagagc    420

accagcggcg gcacagccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg    480

accgtgtcct ggaactctgg agccctgacc tccggcgtgc acaccttccc cgccgtgctc    540

cagagcagcg gcctgtacag cctgagcagc gtggtgacag tgcccagcag cagcctggga    600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag    660

gtggagccca agagctgcga caagacccac acctgccccc cctgccctgc ccctgagctg    720

ctgggcggac cctccgtgtt cctgttcccc cccaagccca aggacaccct gatgatcagc    780

cggacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc tgaggtgaag    840

ttcaattggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc ccgggaggaa    900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg    960

aacggcaagg aatacaagtg caaggtctcc aacaaggccc tgcctgcccc catcgaaaag   1020

accatcagca aggccaaggg ccagcccagg gagccccagg tgtacaccct gcccccctcc   1080

cgggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tggtgaaggg cttctacccc   1140

agcgacatcg ccgtggagtg ggagagcaac ggccagcccg agaacaacta caagaccacc   1200

ccccctgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag   1260

agccggtggc agcagggcaa cgtgttcagc tgctccgtga tgcacgaggc cctgcacaac   1320

cactacaccc agaagagcct gagcctgtcc cccggcaag                          1359


<210>  106
<211>  1359
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,V37A,T40A,P60A,T62S) heavy chain IGHG1 cDNA

<400>  106
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggc ccgacaggcc    120

cccggcaagc ggctggaatg ggtggcctac atcagcaagg gcggaggcag cacctactac    180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagcg cgtcgaccaa gggccccagc gtgttcccgc tagcccccag cagcaagagc    420

accagcggcg gcacagccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg    480

accgtgtcct ggaactctgg agccctgacc tccggcgtgc acaccttccc cgccgtgctc    540

cagagcagcg gcctgtacag cctgagcagc gtggtgacag tgcccagcag cagcctggga    600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag    660

gtggagccca agagctgcga caagacccac acctgccccc cctgccctgc ccctgagctg    720

ctgggcggac cctccgtgtt cctgttcccc cccaagccca aggacaccct gatgatcagc    780

cggacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc tgaggtgaag    840

ttcaattggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc ccgggaggaa    900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg    960

aacggcaagg aatacaagtg caaggtctcc aacaaggccc tgcctgcccc catcgaaaag   1020

accatcagca aggccaaggg ccagcccagg gagccccagg tgtacaccct gcccccctcc   1080

cgggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tggtgaaggg cttctacccc   1140

agcgacatcg ccgtggagtg ggagagcaac ggccagcccg agaacaacta caagaccacc   1200

ccccctgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag   1260

agccggtggc agcagggcaa cgtgttcagc tgctccgtga tgcacgaggc cctgcacaac   1320

cactacaccc agaagagcct gagcctgtcc cccggcaag                          1359


<210>  107
<211>  1359
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,T40A,R44G,A49S,Y50A) heavy chain IGHG1 cDNA

<400>  107
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggt ccgacaggcc    120

cccggcaagg gcctggaatg ggtgagcgcc atcagcaagg gcggaggcag cacctactac    180

cccgacaccg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagcg cgtcgaccaa gggccccagc gtgttcccgc tagcccccag cagcaagagc    420

accagcggcg gcacagccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg    480

accgtgtcct ggaactctgg agccctgacc tccggcgtgc acaccttccc cgccgtgctc    540

cagagcagcg gcctgtacag cctgagcagc gtggtgacag tgcccagcag cagcctggga    600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag    660

gtggagccca agagctgcga caagacccac acctgccccc cctgccctgc ccctgagctg    720

ctgggcggac cctccgtgtt cctgttcccc cccaagccca aggacaccct gatgatcagc    780

cggacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc tgaggtgaag    840

ttcaattggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc ccgggaggaa    900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg    960

aacggcaagg aatacaagtg caaggtctcc aacaaggccc tgcctgcccc catcgaaaag   1020

accatcagca aggccaaggg ccagcccagg gagccccagg tgtacaccct gcccccctcc   1080

cgggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tggtgaaggg cttctacccc   1140

agcgacatcg ccgtggagtg ggagagcaac ggccagcccg agaacaacta caagaccacc   1200

ccccctgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag   1260

agccggtggc agcagggcaa cgtgttcagc tgctccgtga tgcacgaggc cctgcacaac   1320

cactacaccc agaagagcct gagcctgtcc cccggcaag                          1359


<210>  108
<211>  1359
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,A49S,Y50A,P60A,T62S) heavy chain IGHG1 cDNA

<400>  108
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggt ccgacagacc    120

cccggcaagc ggctggaatg ggtgagcgcc atcagcaagg gcggaggcag cacctactac    180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagcg cgtcgaccaa gggccccagc gtgttcccgc tagcccccag cagcaagagc    420

accagcggcg gcacagccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg    480

accgtgtcct ggaactctgg agccctgacc tccggcgtgc acaccttccc cgccgtgctc    540

cagagcagcg gcctgtacag cctgagcagc gtggtgacag tgcccagcag cagcctggga    600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag    660

gtggagccca agagctgcga caagacccac acctgccccc cctgccctgc ccctgagctg    720

ctgggcggac cctccgtgtt cctgttcccc cccaagccca aggacaccct gatgatcagc    780

cggacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc tgaggtgaag    840

ttcaattggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc ccgggaggaa    900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg    960

aacggcaagg aatacaagtg caaggtctcc aacaaggccc tgcctgcccc catcgaaaag   1020

accatcagca aggccaaggg ccagcccagg gagccccagg tgtacaccct gcccccctcc   1080

cgggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tggtgaaggg cttctacccc   1140

agcgacatcg ccgtggagtg ggagagcaac ggccagcccg agaacaacta caagaccacc   1200

ccccctgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag   1260

agccggtggc agcagggcaa cgtgttcagc tgctccgtga tgcacgaggc cctgcacaac   1320

cactacaccc agaagagcct gagcctgtcc cccggcaag                          1359


<210>  109
<211>  1359
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,T40A,R44G,A49S,Y50A,P60A,T62S) heavy chain IGHG1 cDNA

<400>  109
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggt ccgacaggcc    120

cccggcaagg gcctggaatg ggtgagcgcc atcagcaagg gcggaggcag cacctactac    180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc cagaggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagcg cgtcgaccaa gggccccagc gtgttcccgc tagcccccag cagcaagagc    420

accagcggcg gcacagccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg    480

accgtgtcct ggaactctgg agccctgacc tccggcgtgc acaccttccc cgccgtgctc    540

cagagcagcg gcctgtacag cctgagcagc gtggtgacag tgcccagcag cagcctggga    600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag    660

gtggagccca agagctgcga caagacccac acctgccccc cctgccctgc ccctgagctg    720

ctgggcggac cctccgtgtt cctgttcccc cccaagccca aggacaccct gatgatcagc    780

cggacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc tgaggtgaag    840

ttcaattggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc ccgggaggaa    900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg    960

aacggcaagg aatacaagtg caaggtctcc aacaaggccc tgcctgcccc catcgaaaag   1020

accatcagca aggccaaggg ccagcccagg gagccccagg tgtacaccct gcccccctcc   1080

cgggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tggtgaaggg cttctacccc   1140

agcgacatcg ccgtggagtg ggagagcaac ggccagcccg agaacaacta caagaccacc   1200

ccccctgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag   1260

agccggtggc agcagggcaa cgtgttcagc tgctccgtga tgcacgaggc cctgcacaac   1320

cactacaccc agaagagcct gagcctgtcc cccggcaag                          1359


<210>  110
<211>  1359
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH5(K3Q,T40A,R44G,A49S,Y50A,P60A,T62S,R94K) heavy chain IGHG1
       cDNA

<400>  110
gaagtgcagc tgctggaaag cggcggaggc ctggtgcagc ctggcggaag cctgagactg     60

agctgtgccg ccagcggctt caccttcagc acctacacca tgagctgggt ccgacaggcc    120

cccggcaagg gcctggaatg ggtgagcgcc atcagcaagg gcggaggcag cacctactac    180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc caagggcgct    300

atgtacggca acgacttctt ctaccctatg gactactggg gccagggcac caccgtgacc    360

gtgtctagcg cgtcgaccaa gggccccagc gtgttcccgc tagcccccag cagcaagagc    420

accagcggcg gcacagccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg    480

accgtgtcct ggaactctgg agccctgacc tccggcgtgc acaccttccc cgccgtgctc    540

cagagcagcg gcctgtacag cctgagcagc gtggtgacag tgcccagcag cagcctggga    600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag    660

gtggagccca agagctgcga caagacccac acctgccccc cctgccctgc ccctgagctg    720

ctgggcggac cctccgtgtt cctgttcccc cccaagccca aggacaccct gatgatcagc    780

cggacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc tgaggtgaag    840

ttcaattggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc ccgggaggaa    900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg    960

aacggcaagg aatacaagtg caaggtctcc aacaaggccc tgcctgcccc catcgaaaag   1020

accatcagca aggccaaggg ccagcccagg gagccccagg tgtacaccct gcccccctcc   1080

cgggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tggtgaaggg cttctacccc   1140

agcgacatcg ccgtggagtg ggagagcaac ggccagcccg agaacaacta caagaccacc   1200

ccccctgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag   1260

agccggtggc agcagggcaa cgtgttcagc tgctccgtga tgcacgaggc cctgcacaac   1320

cactacaccc agaagagcct gagcctgtcc cccggcaag                          1359


<210>  111
<211>  1359
<212>  DNA
<213>  Artificial

<220>
<223>  GBR VH1(V37A) heavy chain IGHG1 cDNA

<400>  111
gaagtgcagc tgctggaaag cggcggaggg ctggtgcagc caggcggcag cctgaggctg     60

tcctgcgccg ccagcggctt caccttcagc acctacacca tgagctgggc ccgacaggcc    120

ccaggcaagg gcctggaatg ggtgtcctac atcagcaagg gcggaggaag cacctactac    180

cccgacaccg tgaagggcag gttcaccatc agcagggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgag ggccgaggac accgccgtgt actactgcgc caagggcgcc    300

atgtacggca acgacttttt ctaccccatg gactactggg ggcagggcac caccgtgacc    360

gtgtctagcg cgtcgaccaa gggccccagc gtgttcccgc tagcccccag cagcaagagc    420

accagcggcg gcacagccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg    480

accgtgtcct ggaactctgg agccctgacc tccggcgtgc acaccttccc cgccgtgctc    540

cagagcagcg gcctgtacag cctgagcagc gtggtgacag tgcccagcag cagcctggga    600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag    660

gtggagccca agagctgcga caagacccac acctgccccc cctgccctgc ccctgagctg    720

ctgggcggac cctccgtgtt cctgttcccc cccaagccca aggacaccct gatgatcagc    780

cggacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc tgaggtgaag    840

ttcaattggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc ccgggaggaa    900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg    960

aacggcaagg aatacaagtg caaggtctcc aacaaggccc tgcctgcccc catcgaaaag   1020

accatcagca aggccaaggg ccagcccagg gagccccagg tgtacaccct gcccccctcc   1080

cgggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tggtgaaggg cttctacccc   1140

agcgacatcg ccgtggagtg ggagagcaac ggccagcccg agaacaacta caagaccacc   1200

ccccctgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag   1260

agccggtggc agcagggcaa cgtgttcagc tgctccgtga tgcacgaggc cctgcacaac   1320

cactacaccc agaagagcct gagcctgtcc cccggcaag                          1359


<210>  112
<211>  1359
<212>  DNA
<213>  Artificial

<220>
<223>  GBR900 VH3(V37A) heavy chain IGHG1 cDNA

<400>  112
gaagtgcagc tgctggaaag cggcggaggg ctggtgcagc caggcggcag cctgaggctg     60

tcctgcgccg ccagcggctt caccttcagc acctacacca tgagctgggc ccgacagacc    120

cccggcaaga ggctggaatg ggtggcctac atcagcaagg gcggaggaag cacctactac    180

cccgacaccg tgaagggcag gttcaccatc agcagggaca acagcaagaa caccctgtac    240

ctgcagatga acagcctgag ggccgaggac accgccgtgt actactgcgc caagggcgcc    300

atgtacggca acgacttttt ctaccccatg gactactggg ggcagggcac caccgtgacc    360

gtgtctagcg cgtcgaccaa gggccccagc gtgttcccgc tagcccccag cagcaagagc    420

accagcggcg gcacagccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg    480

accgtgtcct ggaactctgg agccctgacc tccggcgtgc acaccttccc cgccgtgctc    540

cagagcagcg gcctgtacag cctgagcagc gtggtgacag tgcccagcag cagcctggga    600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaag    660

gtggagccca agagctgcga caagacccac acctgccccc cctgccctgc ccctgagctg    720

ctgggcggac cctccgtgtt cctgttcccc cccaagccca aggacaccct gatgatcagc    780

cggacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc tgaggtgaag    840

ttcaattggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc ccgggaggaa    900

cagtacaaca gcacctaccg ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg    960

aacggcaagg aatacaagtg caaggtctcc aacaaggccc tgcctgcccc catcgaaaag   1020

accatcagca aggccaaggg ccagcccagg gagccccagg tgtacaccct gcccccctcc   1080

cgggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tggtgaaggg cttctacccc   1140

agcgacatcg ccgtggagtg ggagagcaac ggccagcccg agaacaacta caagaccacc   1200

ccccctgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag   1260

agccggtggc agcagggcaa cgtgttcagc tgctccgtga tgcacgaggc cctgcacaac   1320

cactacaccc agaagagcct gagcctgtcc cccggcaag                          1359


<210>  113
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  VL1 variable domain cDNA

<400>  113
gagatcgtgc tgacccagag ccccgccacc ctgtctctga gccctggcga gagagccacc     60

ctgagctgta gcgcctccag cagcgtgtcc tacatgcact ggtatcagca gaagcccggc    120

caggccccca gactgctgat ctacaccacc agcaacctgg ccagcggcat ccccgccaga    180

ttttctggca gcggcagcgg caccgacttc accctgacca tcagcagcct ggaacccgag    240

gatttcgccg tgtattattg ccaccagtgg tccagctacc cctggacctt cggccagggg    300

accaagctgg aaatcaag                                                  318


<210>  114
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  VL3 variable domain cDNA

<400>  114
cagatcgtgc tgacccagag ccccgccacc ctgagcctga gcccaggcga gagggccacc     60

ctgtcctgca gcgccagcag cagcgtgagc tacatgcact ggtaccagca gaagcccggc    120

cagagcccaa gactgctgat ctacaccacc tccaacctgg ccagcggcat ccccagcagg    180

ttcagcggca gcggctccgg caccttctac accctgacca tcagcagcct ggaacccgag    240

gacttcgccg tgtactactg ccaccagtgg agcagctacc cctggacctt cggcggcggg    300

accaagctgg aaatcaag                                                  318


<210>  115
<211>  639
<212>  DNA
<213>  Artificial

<220>
<223>  BXhVL1 light chain cDNA

<400>  115
gagatcgtgc tgacccagag ccccgccacc ctgtctctga gccctggcga gagagccacc     60

ctgagctgta gcgcctccag cagcgtgtcc tacatgcact ggtatcagca gaagcccggc    120

caggccccca gactgctgat ctacaccacc agcaacctgg ccagcggcat ccccgccaga    180

ttttctggca gcggcagcgg caccgacttc accctgacca tcagcagcct ggaacccgag    240

gatttcgccg tgtattattg ccaccagtgg tccagctacc cctggacctt cggccagggg    300

accaagctgg aaatcaagcg tacggtggcc gctcccagcg tgttcatctt cccccccagc    360

gacgagcagc tgaagagcgg caccgcctcc gtggtgtgcc tgctgaacaa cttctacccc    420

cgggaggcca aggtgcagtg gaaggtggac aacgccctcc agagcggcaa cagccaggaa    480

agcgtcaccg agcaggacag caaggactcc acctacagcc tgagcagcac cctgaccctg    540

agcaaggccg actacgagaa gcacaaggtg tacgcctgcg aggtgaccca ccagggcctg    600

tccagccccg tgaccaagag cttcaaccgg ggcgagtgc                           639


<210>  116
<211>  639
<212>  DNA
<213>  Artificial

<220>
<223>  BXhVL3 light chain cDNA

<400>  116
cagatcgtgc tgacccagag ccccgccacc ctgagcctga gcccaggcga gagggccacc     60

ctgtcctgca gcgccagcag cagcgtgagc tacatgcact ggtaccagca gaagcccggc    120

cagagcccaa gactgctgat ctacaccacc tccaacctgg ccagcggcat ccccagcagg    180

ttcagcggca gcggctccgg caccttctac accctgacca tcagcagcct ggaacccgag    240

gacttcgccg tgtactactg ccaccagtgg agcagctacc cctggacctt cggcggcggg    300

accaagctgg aaatcaagcg tacggtggcc gctcccagcg tgttcatctt cccccccagc    360

gacgagcagc tgaagagcgg caccgcctcc gtggtgtgcc tgctgaacaa cttctacccc    420

cgggaggcca aggtgcagtg gaaggtggac aacgccctcc agagcggcaa cagccaggaa    480

agcgtcaccg agcaggacag caaggactcc acctacagcc tgagcagcac cctgaccctg    540

agcaaggccg actacgagaa gcacaaggtg tacgcctgcg aggtgaccca ccagggcctg    600

tccagccccg tgaccaagag cttcaaccgg ggcgagtgc                           639


