                         SEQUENCE LISTING

<110>  NORTHWESTERN UNIVERSITY
 
<120>  IMPROVED WOUND HEALING THROUGH SIRT1 OVEREXPRESSION

<130>  NWEST-34248/WO-1/ORD

<150>  US 62/084,375
<151>  2014-11-25

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  4110
<212>  DNA
<213>  Homo sapiens

<400>  1
gtcgagcggg agcagaggag gcgagggagg agggccagag aggcagttgg aagatggcgg       60

acgaggcggc cctcgccctt cagcccggcg gctccccctc ggcggcgggg gccgacaggg      120

aggccgcgtc gtcccccgcc ggggagccgc tccgcaagag gccgcggaga gatggtcccg      180

gcctcgagcg gagcccgggc gagcccggtg gggcggcccc agagcgtgag gtgccggcgg      240

cggccagggg ctgcccgggt gcggcggcgg cggcgctgtg gcgggaggcg gaggcagagg      300

cggcggcggc aggcggggag caagaggccc aggcgactgc ggcggctggg gaaggagaca      360

atgggccggg cctgcagggc ccatctcggg agccaccgct ggccgacaac ttgtacgacg      420

aagacgacga cgacgagggc gaggaggagg aagaggcggc ggcggcggcg attgggtacc      480

gagataacct tctgttcggt gatgaaatta tcactaatgg ttttcattcc tgtgaaagtg      540

atgaggagga tagagcctca catgcaagct ctagtgactg gactccaagg ccacggatag      600

gtccatatac ttttgttcag caacatctta tgattggcac agatcctcga acaattctta      660

aagatttatt gccggaaaca atacctccac ctgagttgga tgatatgaca ctgtggcaga      720

ttgttattaa tatcctttca gaaccaccaa aaaggaaaaa aagaaaagat attaatacaa      780

ttgaagatgc tgtgaaatta ctgcaagagt gcaaaaaaat tatagttcta actggagctg      840

gggtgtctgt ttcatgtgga atacctgact tcaggtcaag ggatggtatt tatgctcgcc      900

ttgctgtaga cttcccagat cttccagatc ctcaagcgat gtttgatatt gaatatttca      960

gaaaagatcc aagaccattc ttcaagtttg caaaggaaat atatcctgga caattccagc     1020

catctctctg tcacaaattc atagccttgt cagataagga aggaaaacta cttcgcaact     1080

atacccagaa catagacacg ctggaacagg ttgcgggaat ccaaaggata attcagtgtc     1140

atggttcctt tgcaacagca tcttgcctga tttgtaaata caaagttgac tgtgaagctg     1200

tacgaggaga tatttttaat caggtagttc ctcgatgtcc taggtgccca gctgatgaac     1260

cgcttgctat catgaaacca gagattgtgt tttttggtga aaatttacca gaacagtttc     1320

atagagccat gaagtatgac aaagatgaag ttgacctcct cattgttatt gggtcttccc     1380

tcaaagtaag accagtagca ctaattccaa gttccatacc ccatgaagtg cctcagatat     1440

taattaatag agaacctttg cctcatctgc attttgatgt agagcttctt ggagactgtg     1500

atgtcataat taatgaattg tgtcataggt taggtggtga atatgccaaa ctttgctgta     1560

accctgtaaa gctttcagaa attactgaaa aacctccacg aacacaaaaa gaattggctt     1620

atttgtcaga gttgccaccc acacctcttc atgtttcaga agactcaagt tcaccagaaa     1680

gaacttcacc accagattct tcagtgattg tcacactttt agaccaagca gctaagagta     1740

atgatgattt agatgtgtct gaatcaaaag gttgtatgga agaaaaacca caggaagtac     1800

aaacttctag gaatgttgaa agtattgctg aacagatgga aaatccggat ttgaagaatg     1860

ttggttctag tactggggag aaaaatgaaa gaacttcagt ggctggaaca gtgagaaaat     1920

gctggcctaa tagagtggca aaggagcaga ttagtaggcg gcttgatggt aatcagtatc     1980

tgtttttgcc accaaatcgt tacattttcc atggcgctga ggtatattca gactctgaag     2040

atgacgtctt atcctctagt tcttgtggca gtaacagtga tagtgggaca tgccagagtc     2100

caagtttaga agaacccatg gaggatgaaa gtgaaattga agaattctac aatggcttag     2160

aagatgagcc tgatgttcca gagagagctg gaggagctgg atttgggact gatggagatg     2220

atcaagaggc aattaatgaa gctatatctg tgaaacagga agtaacagac atgaactatc     2280

catcaaacaa atcatagtgt aataattgtg caggtacagg aattgttcca ccagcattag     2340

gaactttagc atgtcaaaat gaatgtttac ttgtgaactc gatagagcaa ggaaaccaga     2400

aaggtgtaat atttataggt tggtaaaata gattgttttt catggataat ttttaacttc     2460

attatttctg tacttgtaca aactcaacac taactttttt ttttttaaaa aaaaaaaggt     2520

actaagtatc ttcaatcagc tgttggtcaa gactaacttt cttttaaagg ttcatttgta     2580

tgataaattc atatgtgtat atataatttt ttttgttttg tctagtgagt ttcaacattt     2640

ttaaagtttt caaaaagcca tcggaatgtt aaattaatgt aaagggaaca gctaatctag     2700

accaaagaat ggtattttca cttttctttg taacattgaa tggtttgaag tactcaaaat     2760

ctgttacgct aaacttttga ttctttaaca caattatttt taaacactgg cattttccaa     2820

aactgtggca gctaactttt taaaatctca aatgacatgc agtgtgagta gaaggaagtc     2880

aacaatatgt ggggagagca ctcggttgtc tttactttta aaagtaatac ttggtgctaa     2940

gaatttcagg attattgtat ttacgttcaa atgaagatgg cttttgtact tcctgtggac     3000

atgtagtaat gtctatattg gctcataaaa ctaacctgaa aaacaaataa atgctttgga     3060

aatgtttcag ttgctttaga aacattagtg cctgcctgga tccccttagt tttgaaatat     3120

ttgccattgt tgtttaaata cctatcactg tggtagagct tgcattgatc ttttccacaa     3180

gtattaaact gccaaaatgt gaatatgcaa agcctttctg aatctataat aatggtactt     3240

ctactgggga gagtgtaata ttttggactg ctgttttcca ttaatgagga gagcaacagg     3300

cccctgatta tacagttcca aagtaataag atgttaattg taattcagcc agaaagtaca     3360

tgtctcccat tgggaggatt tggtgttaaa taccaaactg ctagccctag tattatggag     3420

atgaacatga tgatgtaact tgtaatagca gaatagttaa tgaatgaaac tagttcttat     3480

aatttatctt tatttaaaag cttagcctgc cttaaaacta gagatcaact ttctcagctg     3540

caaaagcttc tagtctttca agaagttcat actttatgaa attgcacagt aagcatttat     3600

ttttcagacc atttttgaac atcactccta aattaataaa gtattcctct gttgctttag     3660

tatttattac aataaaaagg gtttgaaata tagctgttct ttatgcataa aacacccagc     3720

taggaccatt actgccagag aaaaaaatcg tattgaatgg ccatttccct acttataaga     3780

tgtctcaatc tgaatttatt tggctacact aaagaatgca gtatatttag ttttccattt     3840

gcatgatgtt tgtgtgctat agatgatatt ttaaattgaa aagtttgttt taaattattt     3900

ttacagtgaa gactgttttc agctcttttt atattgtaca tagtctttta tgtaatttac     3960

tggcatatgt tttgtagact gtttaatgac tggatatctt ccttcaactt ttgaaataca     4020

aaaccagtgt tttttacttg tacactgttt taaagtctat taaaattgtc atttgacttt     4080

tttctgttaa cttaaaaaaa aaaaaaaaaa                                      4110


<210>  2
<211>  747
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Asp Glu Ala Ala Leu Ala Leu Gln Pro Gly Gly Ser Pro Ser 
1               5                   10                  15      


Ala Ala Gly Ala Asp Arg Glu Ala Ala Ser Ser Pro Ala Gly Glu Pro 
            20                  25                  30          


Leu Arg Lys Arg Pro Arg Arg Asp Gly Pro Gly Leu Glu Arg Ser Pro 
        35                  40                  45              


Gly Glu Pro Gly Gly Ala Ala Pro Glu Arg Glu Val Pro Ala Ala Ala 
    50                  55                  60                  


Arg Gly Cys Pro Gly Ala Ala Ala Ala Ala Leu Trp Arg Glu Ala Glu 
65                  70                  75                  80  


Ala Glu Ala Ala Ala Ala Gly Gly Glu Gln Glu Ala Gln Ala Thr Ala 
                85                  90                  95      


Ala Ala Gly Glu Gly Asp Asn Gly Pro Gly Leu Gln Gly Pro Ser Arg 
            100                 105                 110         


Glu Pro Pro Leu Ala Asp Asn Leu Tyr Asp Glu Asp Asp Asp Asp Glu 
        115                 120                 125             


Gly Glu Glu Glu Glu Glu Ala Ala Ala Ala Ala Ile Gly Tyr Arg Asp 
    130                 135                 140                 


Asn Leu Leu Phe Gly Asp Glu Ile Ile Thr Asn Gly Phe His Ser Cys 
145                 150                 155                 160 


Glu Ser Asp Glu Glu Asp Arg Ala Ser His Ala Ser Ser Ser Asp Trp 
                165                 170                 175     


Thr Pro Arg Pro Arg Ile Gly Pro Tyr Thr Phe Val Gln Gln His Leu 
            180                 185                 190         


Met Ile Gly Thr Asp Pro Arg Thr Ile Leu Lys Asp Leu Leu Pro Glu 
        195                 200                 205             


Thr Ile Pro Pro Pro Glu Leu Asp Asp Met Thr Leu Trp Gln Ile Val 
    210                 215                 220                 


Ile Asn Ile Leu Ser Glu Pro Pro Lys Arg Lys Lys Arg Lys Asp Ile 
225                 230                 235                 240 


Asn Thr Ile Glu Asp Ala Val Lys Leu Leu Gln Glu Cys Lys Lys Ile 
                245                 250                 255     


Ile Val Leu Thr Gly Ala Gly Val Ser Val Ser Cys Gly Ile Pro Asp 
            260                 265                 270         


Phe Arg Ser Arg Asp Gly Ile Tyr Ala Arg Leu Ala Val Asp Phe Pro 
        275                 280                 285             


Asp Leu Pro Asp Pro Gln Ala Met Phe Asp Ile Glu Tyr Phe Arg Lys 
    290                 295                 300                 


Asp Pro Arg Pro Phe Phe Lys Phe Ala Lys Glu Ile Tyr Pro Gly Gln 
305                 310                 315                 320 


Phe Gln Pro Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp Lys Glu 
                325                 330                 335     


Gly Lys Leu Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu Glu Gln 
            340                 345                 350         


Val Ala Gly Ile Gln Arg Ile Ile Gln Cys His Gly Ser Phe Ala Thr 
        355                 360                 365             


Ala Ser Cys Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala Val Arg 
    370                 375                 380                 


Gly Asp Ile Phe Asn Gln Val Val Pro Arg Cys Pro Arg Cys Pro Ala 
385                 390                 395                 400 


Asp Glu Pro Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe Gly Glu 
                405                 410                 415     


Asn Leu Pro Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys Asp Glu 
            420                 425                 430         


Val Asp Leu Leu Ile Val Ile Gly Ser Ser Leu Lys Val Arg Pro Val 
        435                 440                 445             


Ala Leu Ile Pro Ser Ser Ile Pro His Glu Val Pro Gln Ile Leu Ile 
    450                 455                 460                 


Asn Arg Glu Pro Leu Pro His Leu His Phe Asp Val Glu Leu Leu Gly 
465                 470                 475                 480 


Asp Cys Asp Val Ile Ile Asn Glu Leu Cys His Arg Leu Gly Gly Glu 
                485                 490                 495     


Tyr Ala Lys Leu Cys Cys Asn Pro Val Lys Leu Ser Glu Ile Thr Glu 
            500                 505                 510         


Lys Pro Pro Arg Thr Gln Lys Glu Leu Ala Tyr Leu Ser Glu Leu Pro 
        515                 520                 525             


Pro Thr Pro Leu His Val Ser Glu Asp Ser Ser Ser Pro Glu Arg Thr 
    530                 535                 540                 


Ser Pro Pro Asp Ser Ser Val Ile Val Thr Leu Leu Asp Gln Ala Ala 
545                 550                 555                 560 


Lys Ser Asn Asp Asp Leu Asp Val Ser Glu Ser Lys Gly Cys Met Glu 
                565                 570                 575     


Glu Lys Pro Gln Glu Val Gln Thr Ser Arg Asn Val Glu Ser Ile Ala 
            580                 585                 590         


Glu Gln Met Glu Asn Pro Asp Leu Lys Asn Val Gly Ser Ser Thr Gly 
        595                 600                 605             


Glu Lys Asn Glu Arg Thr Ser Val Ala Gly Thr Val Arg Lys Cys Trp 
    610                 615                 620                 


Pro Asn Arg Val Ala Lys Glu Gln Ile Ser Arg Arg Leu Asp Gly Asn 
625                 630                 635                 640 


Gln Tyr Leu Phe Leu Pro Pro Asn Arg Tyr Ile Phe His Gly Ala Glu 
                645                 650                 655     


Val Tyr Ser Asp Ser Glu Asp Asp Val Leu Ser Ser Ser Ser Cys Gly 
            660                 665                 670         


Ser Asn Ser Asp Ser Gly Thr Cys Gln Ser Pro Ser Leu Glu Glu Pro 
        675                 680                 685             


Met Glu Asp Glu Ser Glu Ile Glu Glu Phe Tyr Asn Gly Leu Glu Asp 
    690                 695                 700                 


Glu Pro Asp Val Pro Glu Arg Ala Gly Gly Ala Gly Phe Gly Thr Asp 
705                 710                 715                 720 


Gly Asp Asp Gln Glu Ala Ile Asn Glu Ala Ile Ser Val Lys Gln Glu 
                725                 730                 735     


Val Thr Asp Met Asn Tyr Pro Ser Asn Lys Ser 
            740                 745         


