                         SEQUENCE LISTING

<110>  University of Rochester
       Fasan, Rudi
 
<120>  MYOGLOBIN-BASED CATALYSTS FOR CARBENE TRANSFER REACTIONS

<130>  3400_009PCT

<150>  US 62/084,162
<151>  2014-11-25

<160>  116   

<170>  PatentIn version 3.5

<210>  1
<211>  154
<212>  PRT
<213>  Physeter catodon

<400>  1

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


His Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  2
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  2

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Ala Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


His Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  3
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  3

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Ala Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Val Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


His Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  4
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  4

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Ala Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Trp Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


His Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  5
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  5

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  6
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  6

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


His Gly Val Thr Ala Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  7
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  7

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


His Gly Val Thr Phe Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  8
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  8

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Ala Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  9
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  9

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Ala Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Val Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


His Gly Val Thr Ala Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  10
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  10

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Ala Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Val Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


His Gly Val Thr Phe Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  11
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  11

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Ala Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  12
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  12

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Ala Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Trp Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


His Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Met Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  13
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  13

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Ala Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


His Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ala Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  14
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  14

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


His Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser Ala Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  15
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  15

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


His Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser Asp Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  16
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  16

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


His Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser Glu Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  17
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  17

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


His Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser Tyr Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  18
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  18

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


His Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser Cys Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  19
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  19

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


His Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser Ser Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  20
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  20

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


His Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser Gly Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  21
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  21

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Ala Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser Ala Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  22
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  22

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Ala Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser Asp Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  23
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  23

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Ala Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser Glu Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  24
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  24

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Ala Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser Tyr Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  25
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  25

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Ala Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser Cys Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  26
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  26

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Ala Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser Ser Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  27
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  27

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Ala Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser Gly Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  28
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence


<220>
<221>  MOD_RES
<222>  (94)..(94)
<223>  para-amino-phenylalanine (pAmF)

<400>  28

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


His Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser Xaa Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  29
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence


<220>
<221>  MOD_RES
<222>  (94)..(94)
<223>  3-pyridyl-alanine (3PyA)

<400>  29

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


His Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser Xaa Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  30
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence


<220>
<221>  MOD_RES
<222>  (94)..(94)
<223>  3-methyl-histidine (3MeH)

<400>  30

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


His Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser Xaa Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  31
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence


<220>
<221>  MOD_RES
<222>  (94)..(94)
<223>  para-amino-phenylalanine (pAmF)

<400>  31

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Ala Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser Xaa Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  32
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence


<220>
<221>  MOD_RES
<222>  (94)..(94)
<223>  3-pyridyl-alanine (3PyA)

<400>  32

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Ala Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser Xaa Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  33
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence


<220>
<221>  MOD_RES
<222>  (94)..(94)
<223>  3-methyl-histidine (3MeH)

<400>  33

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Ala Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser Xaa Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  34
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  34

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Leu Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  35
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  35

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr His Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  36
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  36

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Tyr Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  37
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  37

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Cys Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  38
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  38

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Phe Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  39
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  39

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Asn Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  40
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  40

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Lys Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  41
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  41

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Gln Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  42
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  42

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Thr Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  43
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  43

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Trp Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  44
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  44

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Gly Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  45
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  45

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Ser Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  46
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  46

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Ile Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  47
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  47

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Met Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  48
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  48

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Asp Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  49
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  49

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Glu Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  50
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  50

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Pro Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  51
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  51

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Arg Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  52
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  52

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Ser Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  53
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  53

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Ala Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  54
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  54

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Thr Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  55
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  55

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Lys Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  56
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  56

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Asp Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  57
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  57

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Asn Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  58
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  58

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Gln Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  59
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  59

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Met Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  60
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  60

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Phe Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  61
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  61

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Ile Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  62
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  62

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Pro Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  63
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  63

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile His Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  64
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  64

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Tyr Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  65
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  65

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Cys Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  66
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  66

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Gly Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  67
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  67

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Trp Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  68
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  68

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Glu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  69
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  69

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Arg Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  70
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  70

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Tyr Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  71
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  71

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Val Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  72
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  72

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Thr Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  73
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  73

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe His Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  74
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  74

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ser Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  75
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  75

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Tyr Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  76
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  76

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Leu Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  77
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  77

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Trp Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  78
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  78

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ala Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  79
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  79

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Glu Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  80
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  80

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Met Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  81
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  81

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Phe Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  82
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  82

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Cys Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  83
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  83

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Gly Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  84
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  84

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Gln Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  85
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  85

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Pro Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  86
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  86

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Lys Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  87
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  87

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Asp Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  88
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  88

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Arg Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  89
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  89

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Asn Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  90
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  90

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Met Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  91
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  91

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Ile Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  92
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  92

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Trp Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  93
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  93

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Tyr Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  94
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  94

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Ala Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  95
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  95

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Ser Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  96
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  96

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Lys Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  97
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  97

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Pro Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  98
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  98

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Gly Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  99
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  99

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Asn Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  100
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  100

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Asp Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  101
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  101

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Leu Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  102
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  102

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Val Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  103
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  103

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys His Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  104
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  104

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Thr Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  105
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  105

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Glu Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  106
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  106

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Arg Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  107
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  107

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Gln Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  108
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  108

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Cys Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  109
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  109

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Ser Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Leu Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  110
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered sequence

<400>  110

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Ser Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


Val Gly Val Thr Phe Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asn Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu Gly Tyr Gln Gly 
145                 150                 


<210>  111
<211>  1049
<212>  PRT
<213>  Bacillus megaterium

<400>  111

Met Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys 
1               5                   10                  15      


Asn Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys 
            20                  25                  30          


Ile Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Arg 
        35                  40                  45              


Val Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp 
    50                  55                  60                  


Glu Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Phe Val Arg 
65                  70                  75                  80  


Asp Phe Ala Gly Asp Gly Leu Phe Thr Ser Trp Thr His Glu Lys Asn 
                85                  90                  95      


Trp Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala 
            100                 105                 110         


Met Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val 
        115                 120                 125             


Gln Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Pro Glu 
    130                 135                 140                 


Asp Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn 
145                 150                 155                 160 


Tyr Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Thr 
                165                 170                 175     


Ser Met Val Arg Ala Leu Asp Glu Ala Met Asn Lys Leu Gln Arg Ala 
            180                 185                 190         


Asn Pro Asp Asp Pro Ala Tyr Asp Glu Asn Lys Arg Gln Phe Gln Glu 
        195                 200                 205             


Asp Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg 
    210                 215                 220                 


Lys Ala Ser Gly Glu Gln Ser Asp Asp Leu Leu Thr His Met Leu Asn 
225                 230                 235                 240 


Gly Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Glu Asn Ile Arg 
                245                 250                 255     


Tyr Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly 
            260                 265                 270         


Leu Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu 
        275                 280                 285             


Gln Lys Ala Ala Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro 
    290                 295                 300                 


Ser Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn 
305                 310                 315                 320 


Glu Ala Leu Arg Leu Trp Pro Thr Ala Pro Ala Phe Ser Leu Tyr Ala 
                325                 330                 335     


Lys Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp 
            340                 345                 350         


Glu Leu Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp 
        355                 360                 365             


Gly Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser 
    370                 375                 380                 


Ala Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala 
385                 390                 395                 400 


Cys Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly 
                405                 410                 415     


Met Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu 
            420                 425                 430         


Asp Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys 
        435                 440                 445             


Ala Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr 
    450                 455                 460                 


Glu Gln Ser Ala Lys Lys Val Arg Lys Lys Ala Glu Asn Ala His Asn 
465                 470                 475                 480 


Thr Pro Leu Leu Val Leu Tyr Gly Ser Asn Met Gly Thr Ala Glu Gly 
                485                 490                 495     


Thr Ala Arg Asp Leu Ala Asp Ile Ala Met Ser Lys Gly Phe Ala Pro 
            500                 505                 510         


Gln Val Ala Thr Leu Asp Ser His Ala Gly Asn Leu Pro Arg Glu Gly 
        515                 520                 525             


Ala Val Leu Ile Val Thr Ala Ser Tyr Asn Gly His Pro Pro Asp Asn 
    530                 535                 540                 


Ala Lys Gln Phe Val Asp Trp Leu Asp Gln Ala Ser Ala Asp Glu Val 
545                 550                 555                 560 


Lys Gly Val Arg Tyr Ser Val Phe Gly Cys Gly Asp Lys Asn Trp Ala 
                565                 570                 575     


Thr Thr Tyr Gln Lys Val Pro Ala Phe Ile Asp Glu Thr Leu Ala Ala 
            580                 585                 590         


Lys Gly Ala Glu Asn Ile Ala Asp Arg Gly Glu Ala Asp Ala Ser Asp 
        595                 600                 605             


Asp Phe Glu Gly Thr Tyr Glu Glu Trp Arg Glu His Met Trp Ser Asp 
    610                 615                 620                 


Val Ala Ala Tyr Phe Asn Leu Asp Ile Glu Asn Ser Glu Asp Asn Lys 
625                 630                 635                 640 


Ser Thr Leu Ser Leu Gln Phe Val Asp Ser Ala Ala Asp Met Pro Leu 
                645                 650                 655     


Ala Lys Met His Gly Ala Phe Ser Thr Asn Val Val Ala Ser Lys Glu 
            660                 665                 670         


Leu Gln Gln Pro Gly Ser Ala Arg Ser Thr Arg His Leu Glu Ile Glu 
        675                 680                 685             


Leu Pro Lys Glu Ala Ser Tyr Gln Glu Gly Asp His Leu Gly Val Ile 
    690                 695                 700                 


Pro Arg Asn Tyr Glu Gly Ile Val Asn Arg Val Thr Ala Arg Phe Gly 
705                 710                 715                 720 


Leu Asp Ala Ser Gln Gln Ile Arg Leu Glu Ala Glu Glu Glu Lys Leu 
                725                 730                 735     


Ala His Leu Pro Leu Ala Lys Thr Val Ser Val Glu Glu Leu Leu Gln 
            740                 745                 750         


Tyr Val Glu Leu Gln Asp Pro Val Thr Arg Thr Gln Leu Arg Ala Met 
        755                 760                 765             


Ala Ala Lys Thr Val Cys Pro Pro His Lys Val Glu Leu Glu Ala Leu 
    770                 775                 780                 


Leu Glu Lys Gln Ala Tyr Lys Glu Gln Val Leu Ala Lys Arg Leu Thr 
785                 790                 795                 800 


Met Leu Glu Leu Leu Glu Lys Tyr Pro Ala Cys Glu Met Lys Phe Ser 
                805                 810                 815     


Glu Phe Ile Ala Leu Leu Pro Ser Ile Arg Pro Arg Tyr Tyr Ser Ile 
            820                 825                 830         


Ser Ser Ser Pro Arg Val Asp Glu Lys Gln Ala Ser Ile Thr Val Ser 
        835                 840                 845             


Val Val Ser Gly Glu Ala Trp Ser Gly Tyr Gly Glu Tyr Lys Gly Ile 
    850                 855                 860                 


Ala Ser Asn Tyr Leu Ala Glu Leu Gln Glu Gly Asp Thr Ile Thr Cys 
865                 870                 875                 880 


Phe Ile Ser Thr Pro Gln Ser Glu Phe Thr Leu Pro Lys Asp Pro Glu 
                885                 890                 895     


Thr Pro Leu Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Arg 
            900                 905                 910         


Gly Phe Val Gln Ala Arg Lys Gln Leu Lys Glu Gln Gly Gln Ser Leu 
        915                 920                 925             


Gly Glu Ala His Leu Tyr Phe Gly Cys Arg Ser Pro His Glu Asp Tyr 
    930                 935                 940                 


Leu Tyr Gln Glu Glu Leu Glu Asn Ala Gln Ser Glu Gly Ile Ile Thr 
945                 950                 955                 960 


Leu His Thr Ala Phe Ser Arg Met Pro Asn Gln Pro Lys Thr Tyr Val 
                965                 970                 975     


Gln His Val Met Glu Gln Asp Gly Lys Lys Leu Ile Glu Leu Leu Asp 
            980                 985                 990         


Gln Gly Ala His Phe Tyr Ile Cys  Gly Asp Gly Ser Gln  Met Ala Pro 
        995                 1000                 1005             


Ala Val  Glu Ala Thr Leu Met  Lys Ser Tyr Ala Asp  Val His Gln 
    1010                 1015                 1020             


Val Ser  Glu Ala Asp Ala Arg  Leu Trp Leu Gln Gln  Leu Glu Glu 
    1025                 1030                 1035             


Lys Gly  Arg Tyr Ala Lys Asp  Val Trp Ala Gly 
    1040                 1045                 


<210>  112
<211>  179
<212>  PRT
<213>  Xenopus laevis

<400>  112

Met Glu Lys Val Gln Gly Glu Asn Asp Met Glu Arg Trp Glu Arg Leu 
1               5                   10                  15      


Glu Glu Ile Thr Glu Ser Glu Arg Gly Val Ile Lys Glu Thr Trp Ala 
            20                  25                  30          


Arg Val Tyr Ala Asn Cys Glu Asp Val Gly Val Ser Ile Leu Ile Arg 
        35                  40                  45              


Phe Phe Val Asn Phe Pro Ser Ala Lys Gln His Phe Ser Gln Phe Lys 
    50                  55                  60                  


His Met Glu Asp Pro Leu Glu Met Glu Gly Ser Val Gln Leu Arg Lys 
65                  70                  75                  80  


His Gly Arg Arg Val Met Gly Ala Val Asn Ser Val Val Glu Asn Leu 
                85                  90                  95      


Gly Asp Pro Glu Lys Val Thr Thr Val Leu Ser Ile Val Gly Lys Ser 
            100                 105                 110         


His Ala Leu Lys His Lys Val Glu Pro Val Tyr Phe Lys Ile Leu Thr 
        115                 120                 125             


Gly Val Met Leu Glu Val Phe Ala Glu Glu Tyr Ala Lys Asp Phe Thr 
    130                 135                 140                 


Pro Asp Val Gln Leu Val Trp Asn Lys Leu Arg Ser Leu Ile Tyr Ser 
145                 150                 155                 160 


His Val Gln Ser Ala Tyr Lys Glu Val Gly Trp Thr Gln Tyr Pro Ser 
                165                 170                 175     


Asn Ser Val 
            


<210>  113
<211>  147
<212>  PRT
<213>  Channichthys rhinoceratus

<400>  113

Met Ala Asp Phe Asp Met Val Leu Lys Cys Trp Gly Pro Val Glu Ala 
1               5                   10                  15      


Asp His Ala Thr His Gly Ser Leu Val Leu Thr Arg Leu Phe Thr Glu 
            20                  25                  30          


His Pro Glu Thr Leu Lys Leu Phe Pro Lys Phe Ala Gly Ile Ala His 
        35                  40                  45              


Gly Asp Leu Ala Gly Asp Ala Gly Val Ser Ala His Gly Ala Thr Val 
    50                  55                  60                  


Leu Lys Lys Leu Gly Asp Leu Leu Lys Ala Arg Gly Gly His Ala Ala 
65                  70                  75                  80  


Leu Leu Lys Pro Leu Ser Ser Ser His Ala Thr Lys His Lys Ile Pro 
                85                  90                  95      


Ile Ile Asn Phe Lys Leu Ile Ala Glu Val Ile Gly Lys Val Met Glu 
            100                 105                 110         


Glu Lys Ala Gly Leu Asp Ala Ala Gly Gln Thr Ala Leu Arg Asn Val 
        115                 120                 125             


Met Ala Ile Ile Ile Thr Asp Met Glu Ala Asp Tyr Lys Glu Leu Gly 
    130                 135                 140                 


Phe Thr Glu 
145         


<210>  114
<211>  147
<212>  PRT
<213>  Thunnus alalunga

<400>  114

Met Ala Asp Phe Asp Ala Val Leu Lys Cys Trp Gly Pro Val Glu Ala 
1               5                   10                  15      


Asp Tyr Thr Thr Ile Gly Gly Leu Val Leu Thr Arg Leu Phe Lys Glu 
            20                  25                  30          


His Pro Asp Thr Gln Lys Leu Phe Pro Lys Phe Ala Gly Ile Ala Gln 
        35                  40                  45              


Ala Asp Leu Ala Gly Asn Ala Ala Ile Ser Ala His Gly Ala Thr Val 
    50                  55                  60                  


Leu Lys Lys Leu Gly Glu Leu Leu Lys Ala Lys Gly Ser His Ala Ser 
65                  70                  75                  80  


Ile Leu Lys Pro Met Ala Asn Ser His Ala Thr Lys His Lys Ile Pro 
                85                  90                  95      


Ile Asn Asn Phe Lys Leu Ile Ser Glu Val Leu Val Lys Val Met Gln 
            100                 105                 110         


Glu Lys Ala Gly Leu Asp Ala Gly Gly Gln Thr Ala Leu Arg Asn Val 
        115                 120                 125             


Met Gly Ile Ile Ile Ala Asp Leu Glu Ala Asn Tyr Lys Glu Leu Gly 
    130                 135                 140                 


Phe Thr Gly 
145         


<210>  115
<211>  149
<212>  PRT
<213>  Clonorchis sinensis

<400>  115

Met Ala Pro Leu Thr Glu Ser Gln Ile Ala Gly Ile His Glu Glu Leu 
1               5                   10                  15      


Leu Pro His Ile Cys Ser Asp Glu Ala Lys Thr Ser Phe Gly Val Gly 
            20                  25                  30          


Ala Tyr Lys Ala Phe Leu Gly Ala His Pro Glu Tyr Ile Gln His Phe 
        35                  40                  45              


Ser Lys Leu Asn Gly Leu Thr Ile Asp Asn Val Phe Glu Ser Glu Gly 
    50                  55                  60                  


Ile Lys Tyr Tyr Gly Arg Thr Leu Val Asp Glu Ile Val Lys Met Leu 
65                  70                  75                  80  


Thr Ala Gly Ala Asp Asp Glu Lys Leu Gln Gln Leu Leu His Asp Ser 
                85                  90                  95      


Gly Lys Ala His Thr Ala Arg Asn Ile Asp Asn Ala Lys Phe Met Ser 
            100                 105                 110         


Gly Leu Pro Val Phe Val Asp Tyr Phe Asn Arg Ser Leu Thr Val Pro 
        115                 120                 125             


Glu Asn Gln Ile Ala Met Glu Ala Phe Leu Asn His Val Phe Pro Asn 
    130                 135                 140                 


Ile Ser Lys Asp Leu 
145                 


<210>  116
<211>  149
<212>  PRT
<213>  Schistosoma mansoni

<400>  116

Met Thr Ala Val Thr Gln Ser Gln Val Asp His Leu Ile Thr Glu Leu 
1               5                   10                  15      


Glu Pro Gln Val Asp Thr Glu Ala His Gln Glu Glu Leu Gly Leu Lys 
            20                  25                  30          


Val Tyr Glu Cys Phe Leu Lys Ala Arg Pro Glu Tyr Ile Cys Lys Phe 
        35                  40                  45              


Ser Arg Leu Gln Gly Leu Asp Val Ser Asn Phe Ala Gln Ser Glu Gly 
    50                  55                  60                  


Leu Lys Tyr Tyr Ala Arg Thr Phe Val Ser Ala Leu Leu Pro Met Ile 
65                  70                  75                  80  


Lys Ala Ala Ala Asn Lys Cys Glu Leu Asp Lys Leu Cys Leu Asn Glu 
                85                  90                  95      


Ala Val Val His Arg Asn Arg Gln Val Asn Glu Gln Ile Phe Leu Asp 
            100                 105                 110         


Ser Leu Pro Ile Phe Ile Asp Phe Phe Asn Asn Tyr Ile Asn Asp Gln 
        115                 120                 125             


Gln Asn Lys Glu Thr Met Ser Lys Ile Leu Thr Tyr Val Phe Lys Thr 
    130                 135                 140                 


Ile Gly Ser Gln Ile 
145                 


