                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
 
<120>  Non-Human Animals Expressing Humanized CD3 Complex

<130>  7310P1

<150>  62/083,653
<151>  2014-11-24

<150>  62/106,999
<151>  2015-01-23

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  223
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  1
cgactttctt gacttctatt tgttaaacac tgtgcattca catcgaatgc tagaagtttc       60

ctcgtcccgc ttcctcctga attgcctggg atcctctgct tgatgccctg taggaaacgt      120

cctttcctgt ggtatagaaa tgactgctcg agataacttc gtataatgta tgctatacga      180

agttatatgc atggcctccg cgccgggttt tggcgcctcc cgc                        223


<210>  2
<211>  224
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  2
tgtatcttat catgtctgga ataacttcgt ataatgtatg ctatacgaag ttatgctagt       60

aactataacg gtcctaaggt agcgagctag ccttccacag acaccaatgt tcaaaatgga      120

ggcttggggg caaaattctt ttgctatgtc tctagtcgtc caaaaaatgg tcctaacttt      180

ttctgactcc tgcttgtcaa aaattgtggg ctcatagtta atgc                       224


<210>  3
<211>  227
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  3
aggggagaat ggccttcatg cactccctcc tcacctccag cgccttgtgt tttccttgct       60

tagtgatttc ccctctcccc accccacccc ccacagtgtg tgagaactgc atggagatgg      120

atgtgatgtc ggtggccata atcatcattg ttgacatctg tatcactctg ggcttgctga      180

tggtcattta ttactggagc aagaatagga aggccaaggc caagcct                    227


<210>  4
<211>  220
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  4
gaaagagaga gtctttctgc taactaaccc ccagaaggcc ttccggtctc atgtcctgca       60

aagcagtaga cgcccaaagc caggagcaga gttgcgatga ggtcaatgaa gatgacacca      120

gccacggtgg ctggatccag ctccacacag ctctggcaca ctgtggggga agggaggaga      180

gaggagaggt tgagagcctt taagatcagg gaaccatcct                            220


<210>  5
<211>  226
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  5
caagagagac agaagtcaca agaaaaagcc ttcagaaagt tccccaccaa ctgcaggggt       60

caagggggac atgaggatgc cattcaagcg tcgacgagcg taggcagctt attgctctgc      120

atacttacag accatttgtg tagtaaggga catgatgccg agtgaaaggg gcaggagcaa      180

ccagagggag atttcaggaa gttctccagg gactcgaggt tcgtga                     226


<210>  6
<211>  224
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  6
gaagccccac ccagaaaggt aggacaaaga tcatagtcat atttacttca tccaggagag       60

aaacacagac acagccattg ccttggccat catctctctc catcttgacc tcacgtgatc      120

atggcgatcg cgagtgattt agtctacaat ccggaaaact aagtatagat actaccattt      180

tcatggattt ggatctttct tcatcttggc ctcaaataac catg                       224


<210>  7
<211>  216
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  7
gcattattgc agacaggcag gagaaaacga accaggaaaa acaactttcg caacctgaag       60

gtttgtctct ccttttccct acagtgtgtc agaactgcat tgaactaaat gcagccacca      120

tatctggctt tatcttcgct gaggtcatca gcatcttctt ccttgctctt ggtgtatatc      180

tcattgcggg acaggatgga caataccctg tcttaa                                216


<210>  8
<211>  356
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  8
cgactttctt gacttctatt tgttaaacac tgtgcattca catcgaatgc tagaagtttc       60

ctcgtcccgc ttcctcctga attgcctggg atcctctgct tgatgccctg taggaaacgt      120

cctttcctgt ggtatagaaa tgactgctcg agataacttc gtataatgta tgctatacga      180

agttatgcta gtaactataa cggtcctaag gtagcgagct agccttccac agacaccaat      240

gttcaaaatg gaggcttggg ggcaaaattc ttttgctatg tctctagtcg tccaaaaaat      300

ggtcctaact ttttctgact cctgcttgtc aaaaattgtg ggctcatagt taatgc          356


<210>  9
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  9
cctctgccat gtaggtttgt gtac                                              24


<210>  10
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  10
tgccgtgatg tttgttcaat gaccaaa                                           27


<210>  11
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  11
gttctgagaa aggcgttctt aagtg                                             25


<210>  12
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  12
ccaggcgtac ttgctgttct g                                                 21


<210>  13
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  13
tgggcttacc atccaggacg a                                                 21


<210>  14
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  14
gctactcttc ccacaaactg cttag                                             25


<210>  15
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  15
ccagcagtaa gttccactgt tctag                                             25


<210>  16
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  16
tgtagaaatg gctgtgaccc agca                                              24


<210>  17
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  17
gggctgtgtt gcagtatgac                                                   20


<210>  18
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  18
accgtgcaag ttcattatcg aag                                               23


<210>  19
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  19
acgtgcttcc tgaacccttt gggt                                              24


<210>  20
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  20
tctcacatcc agaagcccta tc                                                22


<210>  21
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  21
cgagggatgt atcagtgtaa agga                                              24


<210>  22
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  22
cacagaacaa gtcaaaacca ctccaagtg                                         29


<210>  23
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  23
gctcaccaga acagcaaata ctg                                               23


<210>  24
<211>  207
<212>  PRT
<213>  Artificial

<220>
<223>  chimeric protein

<400>  24

Met Arg Trp Asn Thr Phe Trp Gly Ile Leu Cys Leu Ser Leu Leu Ala 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Ile Ile Ile Ile Val Asp Ile Cys Ile Thr Leu Gly Leu 
    130                 135                 140                 


Leu Met Val Ile Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Thr Gly Ala Gly Ser Arg Pro Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Ala Val 
        195                 200                 205         


<210>  25
<211>  173
<212>  PRT
<213>  Artificial

<220>
<223>  chimeric protein

<400>  25

Met Glu His Ser Gly Ile Leu Ala Ser Leu Ile Leu Ile Ala Val Leu 
1               5                   10                  15      


Pro Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Val Ile Phe Ile Asp Leu 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Tyr Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Pro Ser Gly Ala Ala Glu Val Gln Ala Leu Leu Lys 
    130                 135                 140                 


Asn Glu Gln Leu Tyr Gln Pro Leu Arg Asp Arg Glu Asp Thr Gln Tyr 
145                 150                 155                 160 


Ser Arg Leu Gly Gly Asn Trp Pro Arg Asn Lys Lys Ser 
                165                 170             


<210>  26
<211>  182
<212>  PRT
<213>  Artificial

<220>
<223>  chimeric protein

<400>  26

Met Glu Gln Arg Lys Gly Leu Ala Gly Leu Phe Leu Val Ile Ser Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Ile Phe Ala Glu Val Ile Ser Ile Phe Phe 
        115                 120                 125             


Leu Ala Leu Gly Val Tyr Leu Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Gln Asn Glu Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Tyr Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Lys Lys 
            180         


<210>  27
<211>  189
<212>  PRT
<213>  Mus musculus

<400>  27

Met Arg Trp Asn Thr Phe Trp Gly Ile Leu Cys Leu Ser Leu Leu Ala 
1               5                   10                  15      


Val Gly Thr Cys Gln Asp Asp Ala Glu Asn Ile Glu Tyr Lys Val Ser 
            20                  25                  30          


Ile Ser Gly Thr Ser Val Glu Leu Thr Cys Pro Leu Asp Ser Asp Glu 
        35                  40                  45              


Asn Leu Lys Trp Glu Lys Asn Gly Gln Glu Leu Pro Gln Lys His Asp 
    50                  55                  60                  


Lys His Leu Val Leu Gln Asp Phe Ser Glu Val Glu Asp Ser Gly Tyr 
65                  70                  75                  80  


Tyr Val Cys Tyr Thr Pro Ala Ser Asn Lys Asn Thr Tyr Leu Tyr Leu 
                85                  90                  95      


Lys Ala Arg Val Cys Glu Tyr Cys Val Glu Val Asp Leu Thr Ala Val 
            100                 105                 110         


Ala Ile Ile Ile Ile Val Asp Ile Cys Ile Thr Leu Gly Leu Leu Met 
        115                 120                 125             


Val Ile Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys Pro Val 
    130                 135                 140                 


Thr Arg Gly Thr Gly Ala Gly Ser Arg Pro Arg Gly Gln Asn Lys Glu 
145                 150                 155                 160 


Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly 
                165                 170                 175     


Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Ala Val 
            180                 185                 


<210>  28
<211>  207
<212>  PRT
<213>  homo sapiens

<400>  28

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  29
<211>  173
<212>  PRT
<213>  mus musculus

<400>  29

Met Glu His Ser Gly Ile Leu Ala Ser Leu Ile Leu Ile Ala Val Leu 
1               5                   10                  15      


Pro Gln Gly Ser Pro Phe Lys Ile Gln Val Thr Glu Tyr Glu Asp Lys 
            20                  25                  30          


Val Phe Val Thr Cys Asn Thr Ser Val Met His Leu Asp Gly Thr Val 
        35                  40                  45              


Glu Gly Trp Phe Ala Lys Asn Lys Thr Leu Asn Leu Gly Lys Gly Val 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Leu Cys Asn Gly Thr Glu Gln Leu Ala 
65                  70                  75                  80  


Lys Val Val Ser Ser Val Gln Val His Tyr Arg Met Cys Gln Asn Cys 
                85                  90                  95      


Val Glu Leu Asp Ser Gly Thr Met Ala Gly Val Ile Phe Ile Asp Leu 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Tyr Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Pro Ser Gly Ala Ala Glu Val Gln Ala Leu Leu Lys 
    130                 135                 140                 


Asn Glu Gln Leu Tyr Gln Pro Leu Arg Asp Arg Glu Asp Thr Gln Tyr 
145                 150                 155                 160 


Ser Arg Leu Gly Gly Asn Trp Pro Arg Asn Lys Lys Ser 
                165                 170             


<210>  30
<211>  171
<212>  PRT
<213>  homo sapiens

<400>  30

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
                165                 170     


<210>  31
<211>  182
<212>  PRT
<213>  mus musculus

<400>  31

Met Glu Gln Arg Lys Gly Leu Ala Gly Leu Phe Leu Val Ile Ser Leu 
1               5                   10                  15      


Leu Gln Gly Thr Val Ala Gln Thr Asn Lys Ala Lys Asn Leu Val Gln 
            20                  25                  30          


Val Asp Gly Ser Arg Gly Asp Gly Ser Val Leu Leu Thr Cys Gly Leu 
        35                  40                  45              


Thr Asp Lys Thr Ile Lys Trp Leu Lys Asp Gly Ser Ile Ile Ser Pro 
    50                  55                  60                  


Leu Asn Ala Thr Lys Asn Thr Trp Asn Leu Gly Asn Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Thr Tyr Gln Cys Gln Gly Ala Lys Glu Thr Ser Asn Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Glu Asn Cys Ile Glu Leu Asn Ile 
            100                 105                 110         


Gly Thr Ile Ser Gly Phe Ile Phe Ala Glu Val Ile Ser Ile Phe Phe 
        115                 120                 125             


Leu Ala Leu Gly Val Tyr Leu Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Gln Asn Glu Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Tyr Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Lys Lys 
            180         


<210>  32
<211>  182
<212>  PRT
<213>  homo sapiens

<400>  32

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Arg Asn 
            180         


<210>  33
<211>  113
<212>  PRT
<213>  homo sapiens

<400>  33

Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln 
1               5                   10                  15      


Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys 
            20                  25                  30          


Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn 
        35                  40                  45              


Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His 
    50                  55                  60                  


Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val 
65                  70                  75                  80  


Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr 
                85                  90                  95      


Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met Ser 
            100                 105                 110         


Val 
    


<210>  34
<211>  87
<212>  PRT
<213>  homo sapiens

<400>  34

Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg Val Phe 
1               5                   10                  15      


Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val Gly Thr 
            20                  25                  30          


Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile Leu Asp 
        35                  40                  45              


Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys Asp Lys 
    50                  55                  60                  


Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys Val Glu 
65                  70                  75                  80  


Leu Asp Pro Ala Thr Val Ala 
                85          


<210>  35
<211>  97
<212>  PRT
<213>  homo sapiens

<400>  35

Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys Val Tyr Asp 
1               5                   10                  15      


Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala Glu Ala Lys 
            20                  25                  30          


Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe Leu Thr Glu 
        35                  40                  45              


Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp Pro Arg Gly 
    50                  55                  60                  


Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro Leu Gln Val 
65                  70                  75                  80  


Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala Ala Thr Ile 
                85                  90                  95      


Ser 
    


