                               SEQUENCE LISTING

<110> ALNYLAM PHARMACEUTICALS, INC.
 
<120> TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF

<130> 121301-02920

<140>
<141>

<150> 62/083,691
<151> 2014-11-24

<160> 151   

<170> PatentIn version 3.5

<210> 1
<211> 3212
<212> DNA
<213> Homo sapiens

<400> 1
cttgagccag acccagtcca gctctggtgc ctgccctctg gtgcgagctg acctgagatg       60

cacttccctc ctctgtgagc tgtctcggca cccacttgca gtcactgccg cctgatgttg      120

ttactcttcc actccaaaag gatgcccgtg gccgaggccc cccaggtggc tggcgggcag      180

ggggacggag gtgatggcga ggaagcggag ccggagggga tgttcaaggc ctgtgaggac      240

tccaagagaa aagcccgggg ctacctccgc ctggtgcccc tgtttgtgct gctggccctg      300

ctcgtgctgg cttcggcggg ggtgctactc tggtatttcc tagggtacaa ggcggaggtg      360

atggtcagcc aggtgtactc aggcagtctg cgtgtactca atcgccactt ctcccaggat      420

cttacccgcc gggaatctag tgccttccgc agtgaaaccg ccaaagccca gaagatgctc      480

aaggagctca tcaccagcac ccgcctggga acttactaca actccagctc cgtctattcc      540

tttggggagg gacccctcac ctgcttcttc tggttcattc tccaaatccc cgagcaccgc      600

cggctgatgc tgagccccga ggtggtgcag gcactgctgg tggaggagct gctgtccaca      660

gtcaacagct cggctgccgt cccctacagg gccgagtacg aagtggaccc cgagggccta      720

gtgatcctgg aagccagtgt gaaagacata gctgcattga attccacgct gggttgttac      780

cgctacagct acgtgggcca gggccaggtc ctccggctga aggggcctga ccacctggcc      840

tccagctgcc tgtggcacct gcagggcccc aaggacctca tgctcaaact ccggctggag      900

tggacgctgg cagagtgccg ggaccgactg gccatgtatg acgtggccgg gcccctggag      960

aagaggctca tcacctcggt gtacggctgc agccgccagg agcccgtggt ggaggttctg     1020

gcgtcggggg ccatcatggc ggtcgtctgg aagaagggcc tgcacagcta ctacgacccc     1080

ttcgtgctct ccgtgcagcc ggtggtcttc caggcctgtg aagtgaacct gacgctggac     1140

aacaggctcg actcccaggg cgtcctcagc accccgtact tccccagcta ctactcgccc     1200

caaacccact gctcctggca cctcacggtg ccctctctgg actacggctt ggccctctgg     1260

tttgatgcct atgcactgag gaggcagaag tatgatttgc cgtgcaccca gggccagtgg     1320

acgatccaga acaggaggct gtgtggcttg cgcatcctgc agccctacgc cgagaggatc     1380

cccgtggtgg ccacggccgg gatcaccatc aacttcacct cccagatctc cctcaccggg     1440

cccggtgtgc gggtgcacta tggcttgtac aaccagtcgg acccctgccc tggagagttc     1500

ctctgttctg tgaatggact ctgtgtccct gcctgtgatg gggtcaagga ctgccccaac     1560

ggcctggatg agagaaactg cgtttgcaga gccacattcc agtgcaaaga ggacagcaca     1620

tgcatctcac tgcccaaggt ctgtgatggg cagcctgatt gtctcaacgg cagcgacgaa     1680

gagcagtgcc aggaaggggt gccatgtggg acattcacct tccagtgtga ggaccggagc     1740

tgcgtgaaga agcccaaccc gcagtgtgat gggcggcccg actgcaggga cggctcggat     1800

gaggagcact gtgactgtgg cctccagggc ccctccagcc gcattgttgg tggagctgtg     1860

tcctccgagg gtgagtggcc atggcaggcc agcctccagg ttcggggtcg acacatctgt     1920

gggggggccc tcatcgctga ccgctgggtg ataacagctg cccactgctt ccaggaggac     1980

agcatggcct ccacggtgct gtggaccgtg ttcctgggca aggtgtggca gaactcgcgc     2040

tggcctggag aggtgtcctt caaggtgagc cgcctgctcc tgcacccgta ccacgaagag     2100

gacagccatg actacgacgt ggcgctgctg cagctcgacc acccggtggt gcgctcggcc     2160

gccgtgcgcc ccgtctgcct gcccgcgcgc tcccacttct tcgagcccgg cctgcactgc     2220

tggattacgg gctggggcgc cttgcgcgag ggcggcccca tcagcaacgc tctgcagaaa     2280

gtggatgtgc agttgatccc acaggacctg tgcagcgagg tctatcgcta ccaggtgacg     2340

ccacgcatgc tgtgtgccgg ctaccgcaag ggcaagaagg atgcctgtca gggtgactca     2400

ggtggtccgc tggtgtgcaa ggcactcagt ggccgctggt tcctggcggg gctggtcagc     2460

tggggcctgg gctgtggccg gcctaactac ttcggcgtct acacccgcat cacaggtgtg     2520

atcagctgga tccagcaagt ggtgacctga ggaactgccc ccctgcaaag cagggcccac     2580

ctcctggact cagagagccc agggcaactg ccaagcaggg ggacaagtat tctggcgggg     2640

ggtgggggag agagcaggcc ctgtggtggc aggaggtggc atcttgtctc gtccctgatg     2700

tctgctccag tgatggcagg aggatggaga agtgccagca gctgggggtc aagacgtccc     2760

ctgaggaccc aggcccacac ccagcccttc tgcctcccaa ttctctctcc tccgtcccct     2820

tcctccactg ctgcctaatg caaggcagtg gctcagcagc aagaatgctg gttctacatc     2880

ccgaggagtg tctgaggtgc gccccactct gtacagaggc tgtttgggca gccttgcctc     2940

cagagagcag attccagctt cggaagcccc tggtctaact tgggatctgg gaatggaagg     3000

tgctcccatc ggaggggacc ctcagagccc tggagactgc caggtgggcc tgctgccact     3060

gtaagccaaa aggtggggaa gtcctgactc cagggtcctt gccccacccc tgcctgccac     3120

ctgggccctc acagcccaga ccctcactgg gaggtgagct cagctgccct ttggaataaa     3180

gctgcctgat caaaaaaaaa aaaaaaaaaa aa                                   3212


<210> 2
<211> 16
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      RFGF peptide"

<400> 2
Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


<210> 3
<211> 11
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      RFGF analogue peptide"

<400> 3
Ala Ala Leu Leu Pro Val Leu Leu Ala Ala Pro 
1               5                   10      


<210> 4
<211> 13
<212> PRT
<213> Human immunodeficiency virus

<400> 4
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210> 5
<211> 16
<212> PRT
<213> Drosophila sp.

<400> 5
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210> 6
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 6
cuuacgcuga guacuucgat t                                                 21


<210> 7
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 7
ucgaaguacu cagcguaagt t                                                 21


<210> 8
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 8
ucugguauuu ccuaggguac a                                                 21


<210> 9
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 9
uguacccuag gaaauaccag agu                                               23


<210> 10
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 10
ugguauuucc uaggguacat t                                                 21


<210> 11
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 11
uguacccuag gaaauaccat t                                                 21


<210> 12
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 12
ugguauuucc uaggguacat t                                                 21


<210> 13
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 13
ucugguauuu ccuaggguac a                                                 21


<210> 14
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 14
cugguauuuc cuaggguaca a                                                 21


<210> 15
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 15
ggugcuacuc ugguauuucc u                                                 21


<210> 16
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 16
cacugugacu guggccucca a                                                 21


<210> 17
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 17
caccucccag aucucccuca a                                                 21


<210> 18
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 18
ugguauuucc uaggguacaa a                                                 21


<210> 19
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 19
ccugcccugg agaguuccuc u                                                 21


<210> 20
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 20
uguacccuag gaaauaccat t                                                 21


<210> 21
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 21
uguacccuag gaaauaccag agu                                               23


<210> 22
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 22
uuguacccua ggaaauacca gag                                               23


<210> 23
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 23
aggaaauacc agaguagcac ccc                                               23


<210> 24
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 24
uuggaggcca cagucacagu gcu                                               23


<210> 25
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 25
uugagggaga ucugggaggu gaa                                               23


<210> 26
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 26
uuuguacccu aggaaauacc aga                                               23


<210> 27
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 27
agaggaacuc uccagggcag ggg                                               23


<210> 28
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 28
ugguauuucc uaggguacat t                                                 21


<210> 29
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 29
ucugguauuu ccuaggguac a                                                 21


<210> 30
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 30
cugguauuuc cuaggguaca a                                                 21


<210> 31
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 31
ggugcuacuc ugguauuucc u                                                 21


<210> 32
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 32
cacugugacu guggccucca a                                                 21


<210> 33
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 33
caccucccag aucucccuca a                                                 21


<210> 34
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 34
ugguauuucc uaggguacaa a                                                 21


<210> 35
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 35
ccugcccugg agaguuccuc u                                                 21


<210> 36
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 36
uguacccuag gaaauaccat t                                                 21


<210> 37
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 37
uguacccuag gaaauaccag agu                                               23


<210> 38
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 38
uuguacccua ggaaauacca gag                                               23


<210> 39
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 39
aggaaauacc agaguagcac ccc                                               23


<210> 40
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 40
uuggaggcca cagucacagu gcu                                               23


<210> 41
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 41
uugagggaga ucugggaggu gaa                                               23


<210> 42
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 42
uuuguacccu aggaaauacc aga                                               23


<210> 43
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 43
agaggaacuc uccagggcag ggg                                               23


<210> 44
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 44
cugguauuuc cuaggguaca a                                                 21


<210> 45
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 45
cugguauuuc cuagggtaca a                                                 21


<210> 46
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 46
cugguauuuc cuaggguaca a                                                 21


<210> 47
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 47
cugguauuuc cuaggguaca a                                                 21


<210> 48
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 48
cugguauuuc cuaggguaca a                                                 21


<210> 49
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 49
cugguauuuc cuaggguaca a                                                 21


<210> 50
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 50
cugguauuuc cuagggtaca a                                                 21


<210> 51
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 51
cugguauuuc cuaggguaca a                                                 21


<210> 52
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 52
cugguauuuc cuaggguaca a                                                 21


<210> 53
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 53
uuguacccua ggaaauacca gag                                               23


<210> 54
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 54
uuguacccua ggaaauacca gag                                               23


<210> 55
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 55
uuguacccua ggaaauacca gag                                               23


<210> 56
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 56
uuguacccua ggaaauacca gag                                               23


<210> 57
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 57
uuguacccua ggaaauacca gag                                               23


<210> 58
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 58
uuguacccua ggaaauacca gag                                               23


<210> 59
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 59
uuguacccua ggaaauacca gag                                               23


<210> 60
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 60
uuguacccua ggaaauacca gag                                               23


<210> 61
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 61
uuguacccua ggaaauacca gag                                               23


<210> 62
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 62
cugguauuuc cuaggguaca a                                                 21


<210> 63
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2-hydroxymethyl-tetrahydrofurane-5-phosphate

<400> 63
ncugguauuu ccuaggguac aa                                                22


<210> 64
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 64
cugguauuuc cuaggguaca a                                                 21


<210> 65
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2-hydroxymethyl-tetrahydrofurane-5-phosphate

<400> 65
ncugguauuu ccuaggguac aa                                                22


<210> 66
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 66
cugguauuuc cuaggguaca a                                                 21


<210> 67
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 67
cugguauuuc cuaggguaca a                                                 21


<210> 68
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2-hydroxymethyl-tetrahydrofurane-5-phosphate

<400> 68
ncugguauuu ccuaggguac aa                                                22


<210> 69
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2-hydroxymethyl-tetrahydrofurane-5-phosphate

<400> 69
ncugguauuu ccuaggguac aa                                                22


<210> 70
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 70
cugguauuuc cuagggtaca a                                                 21


<210> 71
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 71
cugguauuuc cuagggtaca a                                                 21


<210> 72
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 72
cugguauuuc cuagggtaca a                                                 21


<210> 73
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 73
cugguauuuc cuagggtaca a                                                 21


<210> 74
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 74
cugguauuuc cuagggtaca a                                                 21


<210> 75
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 75
cugguauuuc cuaggguaca a                                                 21


<210> 76
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 76
cugguauuuc cuaggguaca a                                                 21


<210> 77
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 77
cugguauuuc cuaggguaca a                                                 21


<210> 78
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 78
cugguauuuc cuaggguaca a                                                 21


<210> 79
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 79
cugguauuuc cuaggguaca a                                                 21


<210> 80
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 80
cugguauuuc cuaggguaca a                                                 21


<210> 81
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2-hydroxymethyl-tetrahydrofurane-5-phosphate

<400> 81
ncugguauuu ccuaggguac aa                                                22


<210> 82
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2-hydroxymethyl-tetrahydrofurane-5-phosphate

<400> 82
ncugguauuu ccuaggguac aa                                                22


<210> 83
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2-hydroxymethyl-tetrahydrofurane-5-phosphate

<400> 83
ncugguauuu ccuaggguac aa                                                22


<210> 84
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2-hydroxymethyl-tetrahydrofurane-5-phosphate

<400> 84
ncugguauuu ccuaggguac aa                                                22


<210> 85
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 2-hydroxymethyl-tetrahydrofurane-5-phosphate

<400> 85
ncugguauuu ccuaggguac aa                                                22


<210> 86
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 86
gguauuuccu aggguacaa                                                    19


<210> 87
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 87
uuguacccua ggaaauacca gag                                               23


<210> 88
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 88
uuguacccua ggaaauacca gag                                               23


<210> 89
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 89
uuguacccua ggaaauacca gag                                               23


<210> 90
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 90
uuguacccua ggaaauacca gag                                               23


<210> 91
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 91
uuguacccua ggaaauacca gag                                               23


<210> 92
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 92
uuguacccua ggaaauacca gag                                               23


<210> 93
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 93
uuguacccua ggaaauacca gag                                               23


<210> 94
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 94
uuguacccua ggaaauacca gag                                               23


<210> 95
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 95
uuguacccua ggaaauacca gag                                               23


<210> 96
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 96
uuguacccua ggaaauacca gag                                               23


<210> 97
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 97
uuguacccua ggaaauacca gag                                               23


<210> 98
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 98
uuguacccua ggaaauacca gag                                               23


<210> 99
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 99
uuguacccua ggaaauacca gag                                               23


<210> 100
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 100
uuguacccua ggaaauacca gag                                               23


<210> 101
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 101
uuguacccua ggaaauacca gag                                               23


<210> 102
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 102
uuguacccua ggaaauacca gag                                               23


<210> 103
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 103
uuguacccua ggaaauacca gag                                               23


<210> 104
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 104
uuguacccua ggaaauacca gag                                               23


<210> 105
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 105
uuguacccua ggaaauacca gag                                               23


<210> 106
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 106
uuguacccua ggaaauacca gag                                               23


<210> 107
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 107
uuguacccua ggaaauacca gag                                               23


<210> 108
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 108
uuguacccua ggaaauacca gag                                               23


<210> 109
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 109
uuguacccua ggaaauacca gag                                               23


<210> 110
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 110
uuguacccua ggaaauacca gag                                               23


<210> 111
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 111
uuguacccua ggaaauacca g                                                 21


<210> 112
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 112
cugguauuuc cuaggguaca a                                                 21


<210> 113
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 113
cugguauuuc cuagggtaca a                                                 21


<210> 114
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 114
cugguatuuc cuagggaaca a                                                 21


<210> 115
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 115
cugguatuuc cuagggtaca a                                                 21


<210> 116
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 116
cugguauuuc cuagggtaca a                                                 21


<210> 117
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 117
cugguauuuc cuaggguaca a                                                 21


<210> 118
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 118
ugguatuucc tagggutcaa a                                                 21


<210> 119
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 119
cugguauuuc cuagggtaca a                                                 21


<210> 120
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 120
cugguauuuc cuagggtaca a                                                 21


<210> 121
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 121
cugguauuuc cuagggtaca a                                                 21


<210> 122
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 122
cugguauuuc cuagggaaca a                                                 21


<210> 123
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 123
cugguauuuc cuagggaaca a                                                 21


<210> 124
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 124
cugguauuuc cuagggaaca a                                                 21


<210> 125
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 125
cugguauuuc cuagggtaca a                                                 21


<210> 126
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 126
cugguauuuc cuagggtaca a                                                 21


<210> 127
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 127
cugguauuuc cuagggtaca a                                                 21


<210> 128
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 128
uuguacccua ggaaauacca gag                                               23


<210> 129
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 129
utguacccua ggaaauacca gag                                               23


<210> 130
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 130
utguacccua ggaaauacca gag                                               23


<210> 131
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 131
uuguacccua ggaaauacca gag                                               23


<210> 132
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 132
utguacccua ggaaauacca gag                                               23


<210> 133
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 133
uuguacccua ggaaauacca gag                                               23


<210> 134
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 134
utuguaccct aggaaauacc aga                                               23


<210> 135
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 135
utguacccua ggaaauacca gag                                               23


<210> 136
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 136
uuguacccua ggaaauacca gag                                               23


<210> 137
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 137
utguacccua ggaaauacca gag                                               23


<210> 138
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 138
utguacccua ggaaauacca gag                                               23


<210> 139
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 139
uuguacccua ggaaauacca gag                                               23


<210> 140
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 140
utguacccua ggaaauacca gag                                               23


<210> 141
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 141
utguacccua ggaaauacca gag                                               23


<210> 142
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 142
uuguacccua ggaaauacca gag                                               23


<210> 143
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 143
utguacccua ggaaauacca gag                                               23


<210> 144
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 144
ugguauuucc uaggguacaa a                                                 21


<210> 145
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 145
ugguauuucc uaggguacaa a                                                 21


<210> 146
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 146
ugguauuucc uaggguacaa a                                                 21


<210> 147
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 147
guauuuccua ggguacaaa                                                    19


<210> 148
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 148
uuuguacccu aggaaauacc aga                                               23


<210> 149
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 149
uuuguacccu aggaaauacc aga                                               23


<210> 150
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 150
uuuguacccu aggaaauacc aga                                               23


<210> 151
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 151
uuuguacccu aggaaauacc a                                                 21


