                         SEQUENCE LISTING

<110>  Zang, Xingxing
       Ghosh, Kaya
 
<120>  BTNL9 AND ERMAP AS NOVEL INHIBITORS OF THE IMMUNE SYSTEM FOR 
       IMMUNOTHERAPIES

<130>  96700/2304

<140>  PCT/US2015/60292
<141>  2015-11-12

<150>  US 62/084,124
<151>  2014-11-25

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  535
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Val Asp Leu Ser Val Ser Pro Asp Ser Leu Lys Pro Val Ser Leu 
1               5                   10                  15      


Thr Ser Ser Leu Val Phe Leu Met His Leu Leu Leu Leu Gln Pro Gly 
            20                  25                  30          


Glu Pro Ser Ser Glu Val Lys Val Leu Gly Pro Glu Tyr Pro Ile Leu 
        35                  40                  45              


Ala Leu Val Gly Glu Glu Val Glu Phe Pro Cys His Leu Trp Pro Gln 
    50                  55                  60                  


Leu Asp Ala Gln Gln Met Glu Ile Arg Trp Phe Arg Ser Gln Thr Phe 
65                  70                  75                  80  


Asn Val Val His Leu Tyr Gln Glu Gln Gln Glu Leu Pro Gly Arg Gln 
                85                  90                  95      


Met Pro Ala Phe Arg Asn Arg Thr Lys Leu Val Lys Asp Asp Ile Ala 
            100                 105                 110         


Tyr Gly Ser Val Val Leu Gln Leu His Ser Ile Ile Pro Ser Asp Lys 
        115                 120                 125             


Gly Thr Tyr Gly Cys Arg Phe His Ser Asp Asn Phe Ser Gly Glu Ala 
    130                 135                 140                 


Leu Trp Glu Leu Glu Val Ala Gly Leu Gly Ser Asp Pro His Leu Ser 
145                 150                 155                 160 


Leu Glu Gly Phe Lys Glu Gly Gly Ile Gln Leu Arg Leu Arg Ser Ser 
                165                 170                 175     


Gly Trp Tyr Pro Lys Pro Lys Val Gln Trp Arg Asp His Gln Gly Gln 
            180                 185                 190         


Cys Leu Pro Pro Glu Phe Glu Ala Ile Val Trp Asp Ala Gln Asp Leu 
        195                 200                 205             


Phe Ser Leu Glu Thr Ser Val Val Val Arg Ala Gly Ala Leu Ser Asn 
    210                 215                 220                 


Val Ser Val Ser Ile Gln Asn Leu Leu Leu Ser Gln Lys Lys Glu Leu 
225                 230                 235                 240 


Val Val Gln Ile Ala Asp Val Phe Val Pro Gly Ala Ser Ala Trp Lys 
                245                 250                 255     


Ser Ala Phe Val Ala Thr Leu Pro Leu Leu Leu Val Leu Ala Ala Leu 
            260                 265                 270         


Ala Leu Gly Val Leu Arg Lys Gln Arg Arg Ser Arg Glu Lys Leu Arg 
        275                 280                 285             


Lys Gln Ala Glu Lys Arg Gln Glu Lys Leu Thr Ala Glu Leu Glu Lys 
    290                 295                 300                 


Leu Gln Thr Glu Leu Asp Trp Arg Arg Ala Glu Gly Gln Ala Glu Trp 
305                 310                 315                 320 


Arg Ala Ala Gln Lys Tyr Ala Val Asp Val Thr Leu Asp Pro Ala Ser 
                325                 330                 335     


Ala His Pro Ser Leu Glu Val Ser Glu Asp Gly Lys Ser Val Ser Ser 
            340                 345                 350         


Arg Gly Ala Pro Pro Gly Pro Ala Pro Gly His Pro Gln Arg Phe Ser 
        355                 360                 365             


Glu Gln Thr Cys Ala Leu Ser Leu Glu Arg Phe Ser Ala Gly Arg His 
    370                 375                 380                 


Tyr Trp Glu Val His Val Gly Arg Arg Ser Arg Trp Phe Leu Gly Ala 
385                 390                 395                 400 


Cys Leu Ala Ala Val Pro Arg Ala Gly Pro Ala Arg Leu Ser Pro Ala 
                405                 410                 415     


Ala Gly Tyr Trp Val Leu Gly Leu Trp Asn Gly Cys Glu Tyr Phe Val 
            420                 425                 430         


Leu Ala Pro His Arg Val Ala Leu Thr Leu Arg Val Pro Pro Arg Arg 
        435                 440                 445             


Leu Gly Val Phe Leu Asp Tyr Glu Ala Gly Glu Leu Ser Phe Phe Asn 
    450                 455                 460                 


Val Ser Asp Gly Ser His Ile Phe Thr Phe His Asp Thr Phe Ser Gly 
465                 470                 475                 480 


Ala Leu Cys Ala Tyr Phe Arg Pro Arg Ala His Asp Gly Gly Glu His 
                485                 490                 495     


Pro Asp Pro Leu Thr Ile Cys Pro Leu Pro Val Arg Gly Thr Gly Val 
            500                 505                 510         


Pro Glu Glu Asn Asp Ser Asp Thr Trp Leu Gln Pro Tyr Glu Pro Ala 
        515                 520                 525             


Asp Pro Ala Leu Asp Trp Trp 
    530                 535 


<210>  2
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Met Ala Ser Ser Ala Gly Ser Trp Leu Ser Gly Cys Leu Ile 
1               5                   10                  15      


Pro Leu Val Phe Leu Arg Leu Ser Val His Val Ser Gly His Ala Gly 
            20                  25                  30          


Asp Ala Gly Lys Phe His Val Ala Leu Leu Gly Gly Thr Ala Glu Leu 
        35                  40                  45              


Leu Cys Pro Leu Ser Leu Trp Pro Gly Thr Val Pro Lys Glu Val Arg 
    50                  55                  60                  


Trp Leu Arg Ser Pro Phe Pro Gln Arg Ser Gln Ala Val His Ile Phe 
65                  70                  75                  80  


Arg Asp Gly Lys Asp Gln Asp Glu Asp Leu Met Pro Glu Tyr Lys Gly 
                85                  90                  95      


Arg Thr Val Leu Val Arg Asp Ala Gln Glu Gly Ser Val Thr Leu Gln 
            100                 105                 110         


Ile Leu Asp Val Arg Leu Glu Asp Gln Gly Ser Tyr Arg Cys Leu Ile 
        115                 120                 125             


Gln Val Gly Asn Leu Ser Lys Glu Asp Thr Val Ile Leu Gln Val Ala 
    130                 135                 140                 


Ala Pro Ser Val Gly Ser Leu Ser Pro Ser Ala Val Ala Leu Ala Val 
145                 150                 155                 160 


Ile Leu Pro Val Leu Val Leu Leu Ile Met Val Cys Leu Cys Leu Ile 
                165                 170                 175     


Trp Lys Gln Arg Arg Ala Lys Glu Lys Leu Leu Tyr Glu His Val Thr 
            180                 185                 190         


Glu Val Asp Asn Leu Leu Ser Asp His Ala Lys Glu Lys Gly Lys Leu 
        195                 200                 205             


His Lys Ala Val Lys Lys Leu Arg Ser Glu Leu Lys Leu Lys Arg Ala 
    210                 215                 220                 


Ala Ala Asn Ser Gly Trp Arg Arg Ala Arg Leu His Phe Val Ala Val 
225                 230                 235                 240 


Thr Leu Asp Pro Asp Thr Ala His Pro Lys Leu Ile Leu Ser Glu Asp 
                245                 250                 255     


Gln Arg Cys Val Arg Leu Gly Asp Arg Arg Gln Pro Val Pro Asp Asn 
            260                 265                 270         


Pro Gln Arg Phe Asp Phe Val Val Ser Ile Leu Gly Ser Glu Tyr Phe 
        275                 280                 285             


Thr Thr Gly Cys His Tyr Trp Glu Val Tyr Val Gly Asp Lys Thr Lys 
    290                 295                 300                 


Trp Ile Leu Gly Val Cys Ser Glu Ser Val Ser Arg Lys Gly Lys Val 
305                 310                 315                 320 


Thr Ala Ser Pro Ala Asn Gly His Trp Leu Leu Arg Gln Ser Arg Gly 
                325                 330                 335     


Asn Glu Tyr Glu Ala Leu Thr Ser Pro Gln Thr Ser Phe Arg Leu Lys 
            340                 345                 350         


Glu Pro Pro Arg Cys Val Gly Ile Phe Leu Asp Tyr Glu Ala Gly Val 
        355                 360                 365             


Ile Ser Phe Tyr Asn Val Thr Asn Lys Ser His Ile Phe Thr Phe Thr 
    370                 375                 380                 


His Asn Phe Ser Gly Pro Leu Arg Pro Phe Phe Glu Pro Cys Leu His 
385                 390                 395                 400 


Asp Gly Gly Lys Asn Thr Ala Pro Leu Val Ile Cys Ser Glu Leu His 
                405                 410                 415     


Lys Ser Glu Glu Ser Ile Val Pro Arg Pro Glu Gly Lys Gly His Ala 
            420                 425                 430         


Asn Gly Asp Val Ser Leu Lys Val Asn Ser Ser Leu Leu Pro Pro Lys 
        435                 440                 445             


Ala Pro Glu Leu Lys Asp Ile Ile Leu Ser Leu Pro Pro Asp Leu Gly 
    450                 455                 460                 


Pro Ala Leu Gln Glu Leu Lys Ala Pro Ser Phe 
465                 470                 475 


<210>  3
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Val Asp Cys Pro Arg Tyr Ser Leu Ser Gly Val Ala Ala Ser Phe 
1               5                   10                  15      


Leu Phe Val Leu Leu Thr Ile Lys His Pro Asp Asp Phe Arg Val Val 
            20                  25                  30          


Gly Pro Asn Leu Pro Ile Leu Ala Lys Val Gly Glu Asp Ala Leu Leu 
        35                  40                  45              


Thr Cys Gln Leu Leu Pro Lys Arg Thr Thr Ala His Met Glu Val Arg 
    50                  55                  60                  


Trp Tyr Arg Ser Asp Pro Ala Met Pro Val Ile Met Tyr Arg Asp Gly 
65                  70                  75                  80  


Ala Val Val Thr Gly Leu Pro Met Glu Gly Tyr Gly Gly Arg Ala Glu 
                85                  90                  95      


Trp Met Glu Asp Ser Thr Glu Glu Gly Ser Val Ala Leu Lys Ile Arg 
            100                 105                 110         


Gln Val Gln Pro Ser Asp Asp Gly Gln Tyr Trp Cys Arg Phe Gln Glu 
        115                 120                 125             


Gly Asp Tyr Trp Arg Glu Thr Ser Val Leu Leu Gln Val Ala Ala Leu 
    130                 135                 140                 


Gly Ser Ser Pro Asn Ile His Val Glu Gly Leu Gly Glu Gly Glu Val 
145                 150                 155                 160 


Gln Leu Val Cys Thr Ser Arg Gly Trp Phe Pro Glu Pro Glu Val His 
                165                 170                 175     


Trp Glu Gly Ile Trp Gly Glu Lys Leu Met Ser Phe Ser Glu Asn His 
            180                 185                 190         


Val Pro Gly Glu Asp Gly Leu Phe Tyr Val Glu Asp Thr Leu Met Val 
        195                 200                 205             


Arg Asn Asp Ser Val Glu Thr Ile Ser Cys Phe Ile Tyr Ser His Gly 
    210                 215                 220                 


Leu Arg Glu Thr Gln Glu Ala Thr Ile Ala Leu Ser Glu Arg Leu Gln 
225                 230                 235                 240 


Thr Glu Leu Val Ser Val Ser Val Ile Gly His Ser Gln Pro Ser Pro 
                245                 250                 255     


Val Gln Val Gly Glu Asn Ile Glu Leu Thr Cys His Leu Ser Pro Gln 
            260                 265                 270         


Thr Asp Ala Gln Asn Leu Glu Val Arg Trp Leu Arg Ser Arg Tyr Tyr 
        275                 280                 285             


Pro Ala Val His Val Tyr Ala Asn Gly Thr His Val Ala Gly Glu Gln 
    290                 295                 300                 


Met Val Glu Tyr Lys Gly Arg Thr Ser Leu Val Thr Asp Ala Ile His 
305                 310                 315                 320 


Glu Gly Lys Leu Thr Leu Gln Ile His Asn Ala Arg Thr Ser Asp Glu 
                325                 330                 335     


Gly Gln Tyr Arg Cys Leu Phe Gly Lys Asp Gly Val Tyr Gln Glu Ala 
            340                 345                 350         


Arg Val Asp Val Gln Val Thr Ala Val Gly Ser Thr Pro Arg Ile Thr 
        355                 360                 365             


Arg Glu Val Leu Lys Asp Gly Gly Met Gln Leu Arg Cys Thr Ser Asp 
    370                 375                 380                 


Gly Trp Phe Pro Arg Pro His Val Gln Trp Arg Asp Arg Asp Gly Lys 
385                 390                 395                 400 


Thr Met Pro Ser Phe Ser Glu Ala Phe Gln Gln Gly Ser Gln Glu Leu 
                405                 410                 415     


Phe Gln Val Glu Thr Leu Leu Leu Val Thr Asn Gly Ser Met Val Asn 
            420                 425                 430         


Val Thr Cys Ser Ile Ser Leu Pro Leu Gly Gln Glu Lys Thr Ala Arg 
        435                 440                 445             


Phe Pro Leu Ser Asp Ser Lys Ile 
    450                 455     


<210>  4
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Val Asp Cys Pro Arg Tyr Ser Leu Ser Gly Val Ala Ala Ser Phe 
1               5                   10                  15      


Leu Phe Val Leu Leu Thr Ile Lys His Pro Asp Asp Phe Arg Val Val 
            20                  25                  30          


Gly Pro Asn Leu Pro Ile Leu Ala Lys Val Gly Glu Asp Ala Leu Leu 
        35                  40                  45              


Thr Cys Gln Leu Leu Pro Lys Arg Thr Thr Ala His Met Glu Val Arg 
    50                  55                  60                  


Trp Tyr Arg Ser Asp Pro Ala Met Pro Val Ile Met Tyr Arg Asp Gly 
65                  70                  75                  80  


Ala Val Val Thr Gly Leu Pro Met Glu Gly Tyr Gly Gly Arg Ala Glu 
                85                  90                  95      


Trp Met Glu Asp Ser Thr Glu Glu Gly Ser Val Ala Leu Lys Ile Arg 
            100                 105                 110         


Gln Val Gln Pro Ser Asp Asp Gly Gln Tyr Trp Cys Arg Phe Gln Glu 
        115                 120                 125             


Gly Asp Tyr Trp Arg Glu Thr Ser Val Leu Leu Gln Val Ala Ala Leu 
    130                 135                 140                 


Gly Ser Ser Pro Asn Ile His Val Glu Gly Leu Gly Glu Gly Glu Val 
145                 150                 155                 160 


Gln Leu Val Cys Thr Ser Arg Gly Trp Phe Pro Glu Pro Glu Val His 
                165                 170                 175     


Trp Glu Gly Ile Trp Gly Glu Lys Leu Met Ser Phe Ser Glu Asn His 
            180                 185                 190         


Val Pro Gly Glu Asp Gly Leu Phe Tyr Val Glu Asp Thr Leu Met Val 
        195                 200                 205             


Arg Asn Asp Ser Val Glu Thr Ile Ser Cys Phe Ile Tyr Ser His Gly 
    210                 215                 220                 


Leu Arg Glu Thr Gln Glu Ala Thr Ile Ala Leu Ser Glu Arg Leu Gln 
225                 230                 235                 240 


Thr Glu Leu Val Ser Val Ser Val Ile Gly His Ser Gln Pro Ser Pro 
                245                 250                 255     


Val Gln Val Gly 
            260 


<210>  5
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  5

Lys Gln Ser Glu Asp Phe Arg Val Ile Gly Pro Ala His Pro Ile Leu 
1               5                   10                  15      


Ala Gly Val Gly Glu Asp Ala Leu Leu Thr Cys Gln Leu Leu Pro Lys 
            20                  25                  30          


Arg Thr Thr Met His Val Glu Val Arg Trp Tyr Arg Ser Glu Pro Ser 
        35                  40                  45              


Thr Pro Val Phe Val His Arg Asp Gly Val Glu Val Thr Glu Met Gln 
    50                  55                  60                  


Met Glu Glu Tyr Arg Gly Trp Val Glu Trp Ile Glu Asn Gly Ile Ala 
65                  70                  75                  80  


Lys Gly Asn Val Ala Leu Lys Ile His Asn Ile Gln Pro Ser Asp Asn 
                85                  90                  95      


Gly Gln Tyr Trp Cys His Phe Gln Asp Gly Asn Tyr Cys Gly Glu Thr 
            100                 105                 110         


Ser Leu Leu Leu Lys Val Ala Gly Leu Gly Ser Ala Pro Ser Ile His 
        115                 120                 125             


Met 
    


<210>  6
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  6

Glu Val Lys Val Leu Gly Pro Glu Tyr Pro Ile Leu Ala Leu Val Gly 
1               5                   10                  15      


Glu Glu Val Glu Phe Pro Cys His Leu Trp Pro Gln Leu Asp Ala Gln 
            20                  25                  30          


Gln Met Glu Ile Arg Trp Phe Arg Ser Gln Thr Phe Asn Val Val His 
        35                  40                  45              


Leu Tyr Gln Glu Gln Gln Glu Leu Pro Gly Arg Gln Met Pro Ala Phe 
    50                  55                  60                  


Arg Asn Arg Thr Lys Leu Val Lys Asp Asp Ile Ala Tyr Gly Ser Val 
65                  70                  75                  80  


Val Leu Gln Leu His Ser Ile Ile Pro Ser Asp Lys Gly Thr Tyr Gly 
                85                  90                  95      


Cys Arg Phe His Ser Asp Asn Phe Ser Gly Glu Ala Leu Trp Glu Leu 
            100                 105                 110         


Glu Val Ala Gly Leu Gly Ser Asp Pro His Leu Ser 
        115                 120                 


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial linker sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  sequence can be single or repeat 2, 3, 4, or 5 times

<400>  7

Gly Gly Gly Gly Ser 
1               5   


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial linker sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  sequence can be single or repeat 2, 3, 4, or 5 times

<400>  8

Glu Ala Ala Ala Lys 
1               5   


