                         SEQUENCE LISTING

<110>  Bio-Rap Technologies Ltd.
       KARIN, Nathan
       WILDBAUM, Gizi
 
<120>  NOVEL EPITOPE AS A TARGET FOR THERAPY OF INFLAMMATORY AUTOIMMUNE 
       DISEASES AND GRAFT REJECTION

<130>  P-78561-USP

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  1

Glu Phe Tyr Ser Pro Glu Ala Cys Arg Ser Met 
1               5                   10      


<210>  2
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Phe Phe Ser Pro Glu Ala Cys Arg Ser Met 
1               5                   10      


<210>  3
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Gly Ser Ser Arg Ala Arg Trp Val Ala Leu Gly Leu Gly Ala 
1               5                   10                  15      


Leu Gly Leu Leu Phe Ala Ala Leu Gly Val Val Met Ile Leu Met Val 
            20                  25                  30          


Pro Ser Leu Ile Lys Gln Gln Val Leu Lys Asn Val Arg Ile Asp Pro 
        35                  40                  45              


Ser Ser Leu Ser Phe Gly Met Trp Lys Glu Ile Pro Val Pro Phe Tyr 
    50                  55                  60                  


Leu Ser Val Tyr Phe Phe Glu Val Val Asn Pro Asn Glu Val Leu Asn 
65                  70                  75                  80  


Gly Gln Lys Pro Val Val Arg Glu Arg Gly Pro Tyr Val Tyr Arg Glu 
                85                  90                  95      


Phe Arg Gln Lys Val Asn Ile Thr Phe Asn Asp Asn Asp Thr Val Ser 
            100                 105                 110         


Phe Val Glu Asn Arg Ser Leu His Phe Gln Pro Asp Lys Ser His Gly 
        115                 120                 125             


Ser Glu Ser Asp Tyr Ile Val Leu Pro Asn Ile Leu Val Leu Gly Gly 
    130                 135                 140                 


Ser Ile Leu Met Glu Ser Lys Pro Val Ser Leu Lys Leu Met Met Thr 
145                 150                 155                 160 


Leu Ala Leu Val Thr Met Gly Gln Arg Ala Phe Met Asn Arg Thr Val 
                165                 170                 175     


Gly Glu Ile Leu Trp Gly Tyr Asp Asp Pro Phe Val His Phe Leu Asn 
            180                 185                 190         


Thr Tyr Leu Pro Asp Met Leu Pro Ile Lys Gly Lys Phe Gly Leu Phe 
        195                 200                 205             


Val Gly Met Asn Asn Ser Asn Ser Gly Val Phe Thr Val Phe Thr Gly 
    210                 215                 220                 


Val Gln Asn Phe Ser Arg Ile His Leu Val Asp Lys Trp Asn Gly Leu 
225                 230                 235                 240 


Ser Lys Ile Asp Tyr Trp His Ser Glu Gln Cys Asn Met Ile Asn Gly 
                245                 250                 255     


Thr Ser Gly Gln Met Trp Ala Pro Phe Met Thr Pro Glu Ser Ser Leu 
            260                 265                 270         


Glu Phe Phe Ser Pro Glu Ala Cys Arg Ser Met Lys Leu Thr Tyr Asn 
        275                 280                 285             


Glu Ser Arg Val Phe Glu Gly Ile Pro Thr Tyr Arg Phe Thr Ala Pro 
    290                 295                 300                 


Asp Thr Leu Phe Ala Asn Gly Ser Val Tyr Pro Pro Asn Glu Gly Phe 
305                 310                 315                 320 


Cys Pro Cys Arg Glu Ser Gly Ile Gln Asn Val Ser Thr Cys Arg Phe 
                325                 330                 335     


Gly Ala Pro Leu Phe Leu Ser His Pro His Phe Tyr Asn Ala Asp Pro 
            340                 345                 350         


Val Leu Ser Glu Ala Val Leu Gly Leu Asn Pro Asn Pro Lys Glu His 
        355                 360                 365             


Ser Leu Phe Leu Asp Ile His Pro Val Thr Gly Ile Pro Met Asn Cys 
    370                 375                 380                 


Ser Val Lys Met Gln Leu Ser Leu Tyr Ile Lys Ser Val Lys Gly Ile 
385                 390                 395                 400 


Gly Gln Thr Gly Lys Ile Glu Pro Val Val Leu Pro Leu Leu Trp Phe 
                405                 410                 415     


Glu Gln Ser Gly Ala Met Gly Gly Lys Pro Leu Ser Thr Phe Tyr Thr 
            420                 425                 430         


Gln Leu Val Leu Met Pro Gln Val Leu His Tyr Ala Gln Tyr Val Leu 
        435                 440                 445             


Leu Gly Leu Gly Gly Leu Leu Leu Leu Val Pro Ile Ile Cys Gln Leu 
    450                 455                 460                 


Arg Ser Gln Glu Lys Cys Phe Leu Phe Trp Ser Gly Ser Lys Lys Gly 
465                 470                 475                 480 


Ser Gln Asp Lys Glu Ala Ile Gln Ala Tyr Ser Glu Ser Leu Met Ser 
                485                 490                 495     


Pro Ala Ala Lys Gly Thr Val Leu Gln Glu Ala Lys Leu 
            500                 505                 


<210>  4
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Cys Ser Ala Lys Ala Arg Trp Ala Ala Gly Ala Leu Gly Val 
1               5                   10                  15      


Ala Gly Leu Leu Cys Ala Val Leu Gly Ala Val Met Ile Val Met Val 
            20                  25                  30          


Pro Ser Leu Ile Lys Gln Gln Val Leu Lys Asn Val Arg Ile Asp Pro 
        35                  40                  45              


Ser Ser Leu Ser Phe Asn Met Trp Lys Glu Ile Pro Ile Pro Phe Tyr 
    50                  55                  60                  


Leu Ser Val Tyr Phe Phe Asp Val Met Asn Pro Ser Glu Ile Leu Lys 
65                  70                  75                  80  


Gly Glu Lys Pro Gln Val Arg Glu Arg Gly Pro Tyr Val Tyr Arg Glu 
                85                  90                  95      


Ser Arg His Lys Ser Asn Ile Thr Phe Asn Asn Asn Asp Thr Val Ser 
            100                 105                 110         


Phe Leu Glu Tyr Arg Thr Phe Gln Phe Gln Pro Ser Lys Ser His Gly 
        115                 120                 125             


Ser Glu Ser Asp Tyr Ile Val Met Pro Asn Ile Leu Val Leu Gly Ala 
    130                 135                 140                 


Ala Val Met Met Glu Asn Lys Pro Met Thr Leu Lys Leu Ile Met Thr 
145                 150                 155                 160 


Leu Ala Phe Thr Thr Leu Gly Glu Arg Ala Phe Met Asn Arg Thr Val 
                165                 170                 175     


Gly Glu Ile Met Trp Gly Tyr Lys Asp Pro Leu Val Asn Leu Ile Asn 
            180                 185                 190         


Lys Tyr Phe Pro Gly Met Phe Pro Phe Lys Asp Lys Phe Gly Leu Phe 
        195                 200                 205             


Ala Glu Leu Asn Asn Ser Asp Ser Gly Leu Phe Thr Val Phe Thr Gly 
    210                 215                 220                 


Val Gln Asn Ile Ser Arg Ile His Leu Val Asp Lys Trp Asn Gly Leu 
225                 230                 235                 240 


Ser Lys Val Asp Phe Trp His Ser Asp Gln Cys Asn Met Ile Asn Gly 
                245                 250                 255     


Thr Ser Gly Gln Met Trp Pro Pro Phe Met Thr Pro Glu Ser Ser Leu 
            260                 265                 270         


Glu Phe Tyr Ser Pro Glu Ala Cys Arg Ser Met Lys Leu Met Tyr Lys 
        275                 280                 285             


Glu Ser Gly Val Phe Glu Gly Ile Pro Thr Tyr Arg Phe Val Ala Pro 
    290                 295                 300                 


Lys Thr Leu Phe Ala Asn Gly Ser Ile Tyr Pro Pro Asn Glu Gly Phe 
305                 310                 315                 320 


Cys Pro Cys Leu Glu Ser Gly Ile Gln Asn Val Ser Thr Cys Arg Phe 
                325                 330                 335     


Ser Ala Pro Leu Phe Leu Ser His Pro His Phe Leu Asn Ala Asp Pro 
            340                 345                 350         


Val Leu Ala Glu Ala Val Thr Gly Leu His Pro Asn Gln Glu Ala His 
        355                 360                 365             


Ser Leu Phe Leu Asp Ile His Pro Val Thr Gly Ile Pro Met Asn Cys 
    370                 375                 380                 


Ser Val Lys Leu Gln Leu Ser Leu Tyr Met Lys Ser Val Ala Gly Ile 
385                 390                 395                 400 


Gly Gln Thr Gly Lys Ile Glu Pro Val Val Leu Pro Leu Leu Trp Phe 
                405                 410                 415     


Ala Glu Ser Gly Ala Met Glu Gly Glu Thr Leu His Thr Phe Tyr Thr 
            420                 425                 430         


Gln Leu Val Leu Met Pro Lys Val Met His Tyr Ala Gln Tyr Val Leu 
        435                 440                 445             


Leu Ala Leu Gly Cys Val Leu Leu Leu Val Pro Val Ile Cys Gln Ile 
    450                 455                 460                 


Arg Ser Gln Glu Lys Cys Tyr Leu Phe Trp Ser Ser Ser Lys Lys Gly 
465                 470                 475                 480 


Ser Lys Asp Lys Glu Ala Ile Gln Ala Tyr Ser Glu Ser Leu Met Thr 
                485                 490                 495     


Ser Ala Pro Lys Gly Ser Val Leu Gln Glu Ala Lys Leu 
            500                 505                 


<210>  5
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  5
ggaattccat atggagatga acgtgcgcat cgaccccagt                             40


<210>  6
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  6
cccaagcttc tgagtgtaga atgtgtgaag a                                      31


<210>  7
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  7
gctgatatcg ccccaccaga gccctgcgag                                        30


<210>  8
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  8
cccaagcttt caagctccgg cggtgactac                                        30


<210>  9
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  9
cccaagctta tggagcgtgt gcttggcttg                                        30


<210>  10
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  10
cgcggatcct taaacaaaga ggcgatctcc                                        30


<210>  11
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  11
gctgacactt gggaaatgaa gaactgctta                                        30


<210>  12
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  12
cccaagcttt catgaagtac aagtgacccc                                        30


<210>  13
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  13
gctgacactt gggaaatgaa gaactgctta                                        30


<210>  14
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  14
cccaagcttt catgaagtac aagtgacccc                                        30


<210>  15
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  15
gctgatatcg gagacatgct tattgagaag                                        30


<210>  16
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  16
cccaagcttt cacacaggct ttccttcttt                                        30


<210>  17
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  17
gctgatatca tccatctggt ggataagtg                                         29


<210>  18
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  18
cccaagcttt cagatcccag tgaccgggt                                         29


<210>  19
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  19
cccaagctta tgggctgtga tcggaactgt                                        30


<210>  20
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  20
cgcggatcct tattttccat tcttggattt                                        30


<210>  21
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  21
cccaagctta tggaagacaa taatatgtta c                                      31


<210>  22
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  22
ccgctcgagc acactggttt tatgacaagg c                                      31


<210>  23
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  23
cccaagctta gatctcagaa agaaggttt                                         29


<210>  24
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  24
ccgctcgagc tttaatgttt ggaaactct                                         29


<210>  25
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  25
gctgatatct ttaaaatcga gatctcccc                                         29


<210>  26
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  26
ccggaattct caagagtgct catcctcaa                                         29


<210>  27
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  27

Ile His Leu Val Asp Lys Trp Asn Gly Leu Ser Glu Val Lys Tyr Trp 
1               5                   10                  15      


His Ser Glu Gln Cys Asn Met Ile Asn Gly Thr Ala Gly Gln Met Trp 
            20                  25                  30          


Ala Pro Phe Met Thr Pro Glu Ser Ser Leu Glu Phe Phe Ser Pro Glu 
        35                  40                  45              


Ala Cys Arg Ser Met Lys Leu Thr Tyr Gln Glu Ser Gly Val Phe Glu 
    50                  55                  60                  


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  28

Ile His Leu Val Asp Lys Trp Asn Gly Leu Ser 
1               5                   10      


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  29

Val Asp Lys Trp Asn Gly Leu Ser Glu Val 
1               5                   10  


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  30

Ser Glu Val Lys Tyr Trp His Ser Glu Gln Cys 
1               5                   10      


<210>  31
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  31

Glu Gln Cys Asn Met Ile Asn Gly Thr Ala Gly 
1               5                   10      


<210>  32
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  32

Thr Ala Gly Gln Met Trp Ala Pro Phe Met Thr 
1               5                   10      


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  33

Phe Met Thr Pro Glu Ser Ser Leu Glu Phe Phe 
1               5                   10      


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  34

Glu Phe Phe Ser Pro Glu Ala Cys Arg Ser Met 
1               5                   10      


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  35

Arg Ser Met Lys Leu Thr Tyr Gln Glu Ser 
1               5                   10  


<210>  36
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  36

Gln Glu Ser Gly Val Phe Glu 
1               5           


<210>  37
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  37

Ile His Leu Val Asp Lys Trp Asn Gly Leu Ser Glu Val Lys Tyr Trp 
1               5                   10                  15      


His Ser Glu Gln Cys Asn Met Ile Asn Gly Thr Ala Gly Gln Met Trp 
            20                  25                  30          


Ala Pro Phe Met Thr Pro Glu Ser Ser Leu Glu Phe Phe Ser Pro Glu 
        35                  40                  45              


Ala Cys Arg Ser Met Lys Leu Thr Tyr Gln Glu Ser Arg Val Phe Glu 
    50                  55                  60                  


<210>  38
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  38

Ile His Leu Val Asp Lys Trp Asn Gly Leu Ser Lys Val Asp Phe Trp 
1               5                   10                  15      


His Ser Asp Gln Cys Asn Met Ile Asn Gly Thr Ser Gly Gln Met Trp 
            20                  25                  30          


Pro Pro Phe Met Thr Pro Glu Ser Ser Leu Glu Phe Tyr Ser Pro Glu 
        35                  40                  45              


Ala Cys Arg Ser Met Lys Leu Met Tyr Lys Glu Ser Gly Val Phe Glu 
    50                  55                  60                  


