                         SEQUENCE LISTING

<110>  INSERM (Institut National de la Sant et de la Recherche 
       Mdicale)
       Universit Grenoble I Joseph Fourier
       Universit Paul Sabatier Toulouse III
 
<120>  NUCLEIC ACID ENCODING TRIADIN FOR THE PREVENTION AND/OR TREATMENT
        OF HEART FAILURE

<130>  BET15P3438

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  864
<212>  DNA
<213>  Rattus norvegicus


<220>
<221>  CDS
<222>  (1)..(864)

<400>  1
atg act gag atc aca gct gaa gga aat gca tct ata acc aca act gtg         48
Met Thr Glu Ile Thr Ala Glu Gly Asn Ala Ser Ile Thr Thr Thr Val           
1               5                   10                  15                

ata gac aac aaa aat gga tct gtt ccc aag tcc cct gga aag gtg ctg         96
Ile Asp Asn Lys Asn Gly Ser Val Pro Lys Ser Pro Gly Lys Val Leu           
            20                  25                  30                    

aag agg act gtc acc gaa gac atc gtg aca aca ttc agc tcc cct gca        144
Lys Arg Thr Val Thr Glu Asp Ile Val Thr Thr Phe Ser Ser Pro Ala           
        35                  40                  45                        

gcc tgg ctt ctg gtc atc gct ctg att atc acc tgg tca gct gtt gct        192
Ala Trp Leu Leu Val Ile Ala Leu Ile Ile Thr Trp Ser Ala Val Ala           
    50                  55                  60                            

att gtg atg ttt gat tta gtg gac tac aaa aac ttt tca gca agc tcc        240
Ile Val Met Phe Asp Leu Val Asp Tyr Lys Asn Phe Ser Ala Ser Ser           
65                  70                  75                  80            

atc gcc aag att ggc tct gat cct cta aaa cta gtg aac gat gtt gtg        288
Ile Ala Lys Ile Gly Ser Asp Pro Leu Lys Leu Val Asn Asp Val Val           
                85                  90                  95                

gag gaa aca aca gac tgg atc tat ggc ttc ttc tct ttg tta tct gat        336
Glu Glu Thr Thr Asp Trp Ile Tyr Gly Phe Phe Ser Leu Leu Ser Asp           
            100                 105                 110                   

atc atc tca tct gat ggt gat gaa gat gat gag gat gca gat gag gac        384
Ile Ile Ser Ser Asp Gly Asp Glu Asp Asp Glu Asp Ala Asp Glu Asp           
        115                 120                 125                       

att gac aaa gga gaa ata gaa gaa cct ccc tta aaa aga aaa gac ata        432
Ile Asp Lys Gly Glu Ile Glu Glu Pro Pro Leu Lys Arg Lys Asp Ile           
    130                 135                 140                           

caa aaa gag aag gct gaa aag cag gag aaa cct gag aag aaa ata caa        480
Gln Lys Glu Lys Ala Glu Lys Gln Glu Lys Pro Glu Lys Lys Ile Gln           
145                 150                 155                 160           

act aaa gtt tcg cac aga gaa aag gag aaa gga aaa gaa aaa tta aaa        528
Thr Lys Val Ser His Arg Glu Lys Glu Lys Gly Lys Glu Lys Leu Lys           
                165                 170                 175               

ggc gaa aaa cct gag aag aaa gca act cac aag gag aaa ctt gag aaa        576
Gly Glu Lys Pro Glu Lys Lys Ala Thr His Lys Glu Lys Leu Glu Lys           
            180                 185                 190                   

aaa gaa aga aca gag aca aag atg gca gca aaa gag gac aag aaa att        624
Lys Glu Arg Thr Glu Thr Lys Met Ala Ala Lys Glu Asp Lys Lys Ile           
        195                 200                 205                       

aag act aag gaa aag acc gaa gaa aag gct aag aag gaa atg aaa gtt        672
Lys Thr Lys Glu Lys Thr Glu Glu Lys Ala Lys Lys Glu Met Lys Val           
    210                 215                 220                           

ggg aaa cag gag aaa gcg aaa cca gca gct gca aaa gcc aaa gaa act        720
Gly Lys Gln Glu Lys Ala Lys Pro Ala Ala Ala Lys Ala Lys Glu Thr           
225                 230                 235                 240           

ccg aaa aca aca ccg aaa gcc aga gag aag gat gac aaa gaa acg cca        768
Pro Lys Thr Thr Pro Lys Ala Arg Glu Lys Asp Asp Lys Glu Thr Pro           
                245                 250                 255               

gct gtg ccc aag cat gag cag aaa ggt aaa ctt tcc aag gag gag aag        816
Ala Val Pro Lys His Glu Gln Lys Gly Lys Leu Ser Lys Glu Glu Lys           
            260                 265                 270                   

gag gca gta gga ggt cct aaa aga ata ttg gac aag aag cag ata tag        864
Glu Ala Val Gly Gly Pro Lys Arg Ile Leu Asp Lys Lys Gln Ile               
        275                 280                 285                       


<210>  2
<211>  287
<212>  PRT
<213>  Rattus norvegicus

<400>  2

Met Thr Glu Ile Thr Ala Glu Gly Asn Ala Ser Ile Thr Thr Thr Val 
1               5                   10                  15      


Ile Asp Asn Lys Asn Gly Ser Val Pro Lys Ser Pro Gly Lys Val Leu 
            20                  25                  30          


Lys Arg Thr Val Thr Glu Asp Ile Val Thr Thr Phe Ser Ser Pro Ala 
        35                  40                  45              


Ala Trp Leu Leu Val Ile Ala Leu Ile Ile Thr Trp Ser Ala Val Ala 
    50                  55                  60                  


Ile Val Met Phe Asp Leu Val Asp Tyr Lys Asn Phe Ser Ala Ser Ser 
65                  70                  75                  80  


Ile Ala Lys Ile Gly Ser Asp Pro Leu Lys Leu Val Asn Asp Val Val 
                85                  90                  95      


Glu Glu Thr Thr Asp Trp Ile Tyr Gly Phe Phe Ser Leu Leu Ser Asp 
            100                 105                 110         


Ile Ile Ser Ser Asp Gly Asp Glu Asp Asp Glu Asp Ala Asp Glu Asp 
        115                 120                 125             


Ile Asp Lys Gly Glu Ile Glu Glu Pro Pro Leu Lys Arg Lys Asp Ile 
    130                 135                 140                 


Gln Lys Glu Lys Ala Glu Lys Gln Glu Lys Pro Glu Lys Lys Ile Gln 
145                 150                 155                 160 


Thr Lys Val Ser His Arg Glu Lys Glu Lys Gly Lys Glu Lys Leu Lys 
                165                 170                 175     


Gly Glu Lys Pro Glu Lys Lys Ala Thr His Lys Glu Lys Leu Glu Lys 
            180                 185                 190         


Lys Glu Arg Thr Glu Thr Lys Met Ala Ala Lys Glu Asp Lys Lys Ile 
        195                 200                 205             


Lys Thr Lys Glu Lys Thr Glu Glu Lys Ala Lys Lys Glu Met Lys Val 
    210                 215                 220                 


Gly Lys Gln Glu Lys Ala Lys Pro Ala Ala Ala Lys Ala Lys Glu Thr 
225                 230                 235                 240 


Pro Lys Thr Thr Pro Lys Ala Arg Glu Lys Asp Asp Lys Glu Thr Pro 
                245                 250                 255     


Ala Val Pro Lys His Glu Gln Lys Gly Lys Leu Ser Lys Glu Glu Lys 
            260                 265                 270         


Glu Ala Val Gly Gly Pro Lys Arg Ile Leu Asp Lys Lys Gln Ile 
        275                 280                 285         


<210>  3
<211>  938
<212>  DNA
<213>  Rattus norvegicus

<400>  3
atgactgaga tcacagctga aggaaatgca tctataacca caactgtgat agacaacaaa       60

aatggatctg ttcccaagtc ccctggaaag gtgctgaaga ggactgtcac cgaagacatc      120

gtgacaacat tcagctcccc tgcagcctgg cttctggtca tcgctctgat tatcacctgg      180

tcagctgttg ctattgtgat gtttgattta gtggactaca aaaacttttc agcaagctcc      240

atcgccaaga ttggctctga tcctctaaaa ctagtgaacg atgttgtgga ggaaacaaca      300

gactggatct atggcttctt ctctttgtta tctgatatca tctcatctga tggtgatgaa      360

gatgatgagg atgcagatga ggacattgac aaaggagaaa tagaagaacc tcccttaaaa      420

agaaaagaca tacaaaaaga gaaggctgaa aagcaggaga aacctgagaa gaaaatacaa      480

actaaagttt cgcacagaga aaaggagaaa ggaaaagaaa aattaaaagg cgaaaaacct      540

gagaagaaag caactcacaa ggagaaactt gagaaaaaag aaagaacaga gacaaagatg      600

gcagcaaaag aggacaagaa aattaagact aaggaaaaga ccgaagaaaa ggctaagaag      660

gaaatgaaag ttgggaaaca ggagaaagcg aaaccagcag ctgcaaaagc caaagaaact      720

ccgaaaacaa caccgaaagc cagagagaag gatgacaaag aaacgccagc tgtgcccaag      780

catgagcaga aaggtaaact ttccaaggag gagaaggagg cagtaggagg tcctaaaaga      840

atattggaca agaagcagat atagtcaagt taaactccga aaaagactaa aattaaacct      900

cagatggagg aaaaagatat ccaagtcaat atgcctga                              938


<210>  4
<211>  5575
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid pZac2.1 comprising Triadin 32 kDa rattus norvegicus


<220>
<221>  misc_difference
<222>  (1523)..(1528)
<223>  Kpn1 restriction site

<220>
<221>  misc_feature
<222>  (1589)..(2452)
<223>  triadin coding sequence

<220>
<221>  misc_feature
<222>  (2577)..(2584)
<223>  Not1 restriction site

<400>  4
agcgcccaat acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc       60

acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc      120

tcactcatta ggcaccccag gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa      180

ttgtgagcgg ataacaattt cacacaggaa acagctatga ccatgattac gccagattta      240

attaaggcct taattaggct gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc      300

gggcgtcggg cgacctttgg tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga      360

gtggccaact ccatcactag gggttccttg tagttaatga ttaacccgcc atgctactta      420

tctacgtagc catgctctag gaagatcttc aatattggcc attagccata ttattcattg      480

gttatatagc ataaatcaat attggctatt ggccattgca tacgttgtat ctatatcata      540

atatgtacat ttatattggc tcatgtccaa tatgaccgcc atgttggcat tgattattga      600

ctagttatta atagtaatca attacggggt cattagttca tagcccatat atggagttcc      660

gcgttacata acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat      720

tgacgtcaat aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc      780

aatgggtgga gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc      840

caagtccgcc ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt      900

acatgacctt acgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta      960

ccatggtgat gcggttttgg cagtacacca atgggcgtgg atagcggttt gactcacggg     1020

gatttccaag tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac     1080

gggactttcc aaaatgtcgt aataaccccg ccccgttgac gcaaatgggc ggtaggcgtg     1140

tacggtggga ggtctatata agcagagctc gtttagtgaa ccgtcagatc actagaagct     1200

ttattgcggt agtttatcac agttaaattg ctaacgcagt cagtgcttct gacacaacag     1260

tctcgaactt aagctgcaga agttggtcgt gaggcactgg gcaggtaagt atcaaggtta     1320

caagacaggt ttaaggagac caatagaaac tgggcttgtc gagacagaga agactcttgc     1380

gtttctgata ggcacctatt ggtcttactg acatccactt tgcctttctc tccacaggtg     1440

tccactccca gttcaattac agctcttaag gctagagtac ttaatacgac tcactatagg     1500

ctagcctcga gaattcacgc gtggtaccga gctcggatcc actagtccag tgtggtggaa     1560

ttcgccctta ttgatttctg cacccaccat gactgagatc acagctgaag gaaatgcatc     1620

tataaccaca actgtgatag acaacaaaaa tggatctgtt cccaagtccc ctggaaaggt     1680

gctgaagagg actgtcaccg aagacatcgt gacaacattc agctcccctg cagcctggct     1740

tctggtcatc gccctgatta tcacctggtc agctgttgct attgtgatgt ttgatttagt     1800

ggactacaaa aacttttcag caagctccat cgccaagatt ggctctgatc ctctaaaact     1860

agtgaacgat gctgtggagg aaacaacaga ctggatctat ggcttcttct ctttgctatc     1920

tgatatcatc tcatctgatg gtgatgaaga tgatgaggat gcagatgagg acattgacaa     1980

aggagaaata gaagaacctc ccttaaaaag aaaagaaata caaaaagaga aggctgaaaa     2040

gcaggagaaa cctgagaaga aaatacaaac taaagtttcg cacagagaaa aggagaaagg     2100

aaaagaaaaa ttaaaaggag aaaaacctga gaagaaagca actcacaagg agaaacttga     2160

gaaaaaagaa agaacagaga caaagatggc agcaaaagag gacaagaaaa ttaagactaa     2220

ggaaaagacc gaagaaaagg ctaagaagga aatgaaagtt gggaaacagg agaaagcgaa     2280

accagcagct gcaaaagcca aagaaactcc gaaaacaaca ccgaaagcca gagagaagga     2340

tgacaaagaa acgccagctg tgcccaagca tgagcagaaa ggtaaacttt ccaaggagga     2400

gaaggaggca gtaggaggtc ctaaaagaat attggacaag aagcagatat agtcaagtta     2460

aactccgaaa aagactaaaa ttaaacctca gatggaggaa aaagatatcc aagtcaatat     2520

gcctgaagta catacggcca ctggaagggc gaattctgca gatatccagc acagtggcgg     2580

ccgcttcgag cagacatgat aagatacatt gatgagtttg gacaaaccac aactagaatg     2640

cagtgaaaaa aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt     2700

ataagctgca ataaacaagt taacaacaac aattgcattc attttatgtt tcaggttcag     2760

ggggagatgt gggaggtttt ttaaagcaag taaaacctct acaaatgtgg taaaatcgat     2820

aaggatcttc ctagagcatg gctacgtaga taagtagcat ggcgggttaa tcattaacta     2880

caaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct cgctcactga     2940

ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct cagtgagcga     3000

gcgagcgcgc agccttaatt aacctaattc actggccgtc gttttacaac gtcgtgactg     3060

ggaaaaccct ggcgttaccc aacttaatcg ccttgcagca catccccctt tcgccagctg     3120

gcgtaatagc gaagaggccc gcaccgatcg cccttcccaa cagttgcgca gcctgaatgg     3180

cgaatgggac gcgccctgta gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag     3240

cgtgaccgct acacttgcca gcgccctagc gcccgctcct ttcgctttct tcccttcctt     3300

tctcgccacg ttcgccggct ttccccgtca agctctaaat cgggggctcc ctttagggtt     3360

ccgatttagt gctttacggc acctcgaccc caaaaaactt gattagggtg atggttcacg     3420

tagtgggcca tcgccctgat agacggtttt tcgccctttg acgttggagt ccacgttctt     3480

taatagtgga ctcttgttcc aaactggaac aacactcaac cctatctcgg tctattcttt     3540

tgatttataa gggattttgc cgatttcggc ctattggtta aaaaatgagc tgatttaaca     3600

aaaatttaac gcgaatttta acaaaatatt aacgcttaca atttaggtgg cacttttcgg     3660

ggaaatgtgc gcggaacccc tatttgttta tttttctaaa tacattcaaa tatgtatccg     3720

ctcatgagac aataaccctg ataaatgctt caataatatt gaaaaaggaa gagtatgagt     3780

attcaacatt tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt     3840

gctcacccag aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg     3900

ggttacatcg aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa     3960

cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt     4020

gacgccgggc aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag     4080

tactcaccag tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt     4140

gctgccataa ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga     4200

ccgaaggagc taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt     4260

tgggaaccgg agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta     4320

gcaatggcaa caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg     4380

caacaattaa tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc     4440

cttccggctg gctggtttat tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt     4500

atcattgcag cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg     4560

gggagtcagg caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg     4620

attaagcatt ggtaactgtc agaccaagtt tactcatata tactttagat tgatttaaaa     4680

cttcattttt aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa     4740

atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga     4800

tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg     4860

ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact     4920

ggcttcagca gagcgcagat accaaatact gttcttctag tgtagccgta gttaggccac     4980

cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg     5040

gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg     5100

gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga     5160

acgacctaca ccgaactgag atacctacag cgtgagctat gagaaagcgc cacgcttccc     5220

gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg     5280

agggagcttc cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc     5340

tgacttgagc gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc     5400

agcaacgcgg cctttttacg gttcctggcc ttttgctggc cttttgctca catgttcttt     5460

cctgcgttat cccctgattc tgtggataac cgtattaccg cctttgagtg agctgatacc     5520

gctcgccgca gccgaacgac cgagcgcagc gagtcagtga gcgaggaagc ggaag          5575


<210>  5
<211>  861
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(861)

<400>  5
atg act gag atc act gct gaa gga aat gca tct aca acc aca act gtg         48
Met Thr Glu Ile Thr Ala Glu Gly Asn Ala Ser Thr Thr Thr Thr Val           
1               5                   10                  15                

ata gac agc aaa aat gga tct gtg ccc aaa tcc ccc gga aaa gtg ctg         96
Ile Asp Ser Lys Asn Gly Ser Val Pro Lys Ser Pro Gly Lys Val Leu           
            20                  25                  30                    

aag agg aca gtc aca gaa gac ata gtg acg acg ttc agc tcc cct gca        144
Lys Arg Thr Val Thr Glu Asp Ile Val Thr Thr Phe Ser Ser Pro Ala           
        35                  40                  45                        

gcc tgg ctt ctg gtc att gcc ctg ata atc acg tgg tca gct gtt gcc        192
Ala Trp Leu Leu Val Ile Ala Leu Ile Ile Thr Trp Ser Ala Val Ala           
    50                  55                  60                            

atc gtt atg ttt gat tta gtg gat tac aaa aac ttt tca gca agc tct        240
Ile Val Met Phe Asp Leu Val Asp Tyr Lys Asn Phe Ser Ala Ser Ser           
65                  70                  75                  80            

att gcc aag att ggc tca gat cct tta aaa ctg gta cgt gat gct atg        288
Ile Ala Lys Ile Gly Ser Asp Pro Leu Lys Leu Val Arg Asp Ala Met           
                85                  90                  95                

gag gaa acc acg gac tgg atc tat ggc ttc ttt tct ttg tta tct gac        336
Glu Glu Thr Thr Asp Trp Ile Tyr Gly Phe Phe Ser Leu Leu Ser Asp           
            100                 105                 110                   

atc atc tca tct gaa gat gaa gaa gat gat gat ggt gac gaa gat act        384
Ile Ile Ser Ser Glu Asp Glu Glu Asp Asp Asp Gly Asp Glu Asp Thr           
        115                 120                 125                       

gat aaa gga gaa ata gat gag cct ccc ttg aga aaa aaa gaa ata cac        432
Asp Lys Gly Glu Ile Asp Glu Pro Pro Leu Arg Lys Lys Glu Ile His           
    130                 135                 140                           

aaa gat aag act gaa aaa caa gag aaa cct gaa agg aaa ata caa act        480
Lys Asp Lys Thr Glu Lys Gln Glu Lys Pro Glu Arg Lys Ile Gln Thr           
145                 150                 155                 160           

aaa gtt aca cac aaa gaa aaa gaa aaa gga aaa gaa aaa gta aga gaa        528
Lys Val Thr His Lys Glu Lys Glu Lys Gly Lys Glu Lys Val Arg Glu           
                165                 170                 175               

aaa gaa aaa cct gaa aag aaa gca act cac aag gaa aaa att gag aaa        576
Lys Glu Lys Pro Glu Lys Lys Ala Thr His Lys Glu Lys Ile Glu Lys           
            180                 185                 190                   

aaa gaa aaa cca gaa aca aag aca ctg gcg aaa gaa cag aag aaa gct        624
Lys Glu Lys Pro Glu Thr Lys Thr Leu Ala Lys Glu Gln Lys Lys Ala           
        195                 200                 205                       

aag act gca gaa aag agt gaa gaa aag act aaa aag gaa gtg aaa ggt        672
Lys Thr Ala Glu Lys Ser Glu Glu Lys Thr Lys Lys Glu Val Lys Gly           
    210                 215                 220                           

gga aaa cag gag aaa gtg aag caa aca gct gca aaa gta aaa gaa gta        720
Gly Lys Gln Glu Lys Val Lys Gln Thr Ala Ala Lys Val Lys Glu Val           
225                 230                 235                 240           

cag aaa aca cca tca aaa ccc aaa gaa aag gag gac aaa gag aaa gca        768
Gln Lys Thr Pro Ser Lys Pro Lys Glu Lys Glu Asp Lys Glu Lys Ala           
                245                 250                 255               

gct gtg tca aag cat gaa cag aaa ggt aaa cat tca gag cag gag gct        816
Ala Val Ser Lys His Glu Gln Lys Gly Lys His Ser Glu Gln Glu Ala           
            260                 265                 270                   

gcc gga ggt tct aag aga ata ttg ggc aag aag cac atg cag tga            861
Ala Gly Gly Ser Lys Arg Ile Leu Gly Lys Lys His Met Gln                   
        275                 280                 285                       


<210>  6
<211>  286
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Thr Glu Ile Thr Ala Glu Gly Asn Ala Ser Thr Thr Thr Thr Val 
1               5                   10                  15      


Ile Asp Ser Lys Asn Gly Ser Val Pro Lys Ser Pro Gly Lys Val Leu 
            20                  25                  30          


Lys Arg Thr Val Thr Glu Asp Ile Val Thr Thr Phe Ser Ser Pro Ala 
        35                  40                  45              


Ala Trp Leu Leu Val Ile Ala Leu Ile Ile Thr Trp Ser Ala Val Ala 
    50                  55                  60                  


Ile Val Met Phe Asp Leu Val Asp Tyr Lys Asn Phe Ser Ala Ser Ser 
65                  70                  75                  80  


Ile Ala Lys Ile Gly Ser Asp Pro Leu Lys Leu Val Arg Asp Ala Met 
                85                  90                  95      


Glu Glu Thr Thr Asp Trp Ile Tyr Gly Phe Phe Ser Leu Leu Ser Asp 
            100                 105                 110         


Ile Ile Ser Ser Glu Asp Glu Glu Asp Asp Asp Gly Asp Glu Asp Thr 
        115                 120                 125             


Asp Lys Gly Glu Ile Asp Glu Pro Pro Leu Arg Lys Lys Glu Ile His 
    130                 135                 140                 


Lys Asp Lys Thr Glu Lys Gln Glu Lys Pro Glu Arg Lys Ile Gln Thr 
145                 150                 155                 160 


Lys Val Thr His Lys Glu Lys Glu Lys Gly Lys Glu Lys Val Arg Glu 
                165                 170                 175     


Lys Glu Lys Pro Glu Lys Lys Ala Thr His Lys Glu Lys Ile Glu Lys 
            180                 185                 190         


Lys Glu Lys Pro Glu Thr Lys Thr Leu Ala Lys Glu Gln Lys Lys Ala 
        195                 200                 205             


Lys Thr Ala Glu Lys Ser Glu Glu Lys Thr Lys Lys Glu Val Lys Gly 
    210                 215                 220                 


Gly Lys Gln Glu Lys Val Lys Gln Thr Ala Ala Lys Val Lys Glu Val 
225                 230                 235                 240 


Gln Lys Thr Pro Ser Lys Pro Lys Glu Lys Glu Asp Lys Glu Lys Ala 
                245                 250                 255     


Ala Val Ser Lys His Glu Gln Lys Gly Lys His Ser Glu Gln Glu Ala 
            260                 265                 270         


Ala Gly Gly Ser Lys Arg Ile Leu Gly Lys Lys His Met Gln 
        275                 280                 285     


<210>  7
<211>  834
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(834)

<400>  7
atg act gag atc act gct gaa gga aat gca tcg aca acc aca acg gtg         48
Met Thr Glu Ile Thr Ala Glu Gly Asn Ala Ser Thr Thr Thr Thr Val           
1               5                   10                  15                

ata gac aac aaa aat gga tgt att cct aaa tcc cct gga aag gtg ctg         96
Ile Asp Asn Lys Asn Gly Cys Ile Pro Lys Ser Pro Gly Lys Val Leu           
            20                  25                  30                    

aag aag tct gtc acc gaa gac att gtg aca aca ttc agt tcc cct gca        144
Lys Lys Ser Val Thr Glu Asp Ile Val Thr Thr Phe Ser Ser Pro Ala           
        35                  40                  45                        

gcc tgg ctt ctt gtc atc gct ctg att atc aca tgg tca gct gtt gct        192
Ala Trp Leu Leu Val Ile Ala Leu Ile Ile Thr Trp Ser Ala Val Ala           
    50                  55                  60                            

atc gtg atg ttt gat tta gtg gat tat aaa aac ttt tca gca agc tcc        240
Ile Val Met Phe Asp Leu Val Asp Tyr Lys Asn Phe Ser Ala Ser Ser           
65                  70                  75                  80            

att gcc aag att ggc tca gat cct cta aaa cta gtg aat gat gct gtg        288
Ile Ala Lys Ile Gly Ser Asp Pro Leu Lys Leu Val Asn Asp Ala Val           
                85                  90                  95                

gag gag aca aca gac tgg atc tat ggc ttc ttc tct ttg cta tct gac        336
Glu Glu Thr Thr Asp Trp Ile Tyr Gly Phe Phe Ser Leu Leu Ser Asp           
            100                 105                 110                   

atc atc tca tct gaa ggt gac gaa gat gat gag gat gca gat gaa gac        384
Ile Ile Ser Ser Glu Gly Asp Glu Asp Asp Glu Asp Ala Asp Glu Asp           
        115                 120                 125                       

att gat aaa gga gaa ata gaa gaa cct ccc tta aaa aga aaa gaa ata        432
Ile Asp Lys Gly Glu Ile Glu Glu Pro Pro Leu Lys Arg Lys Glu Ile           
    130                 135                 140                           

cac caa gaa aag gct gaa aaa gag gag aaa cct gag aag aaa ata caa        480
His Gln Glu Lys Ala Glu Lys Glu Glu Lys Pro Glu Lys Lys Ile Gln           
145                 150                 155                 160           

act aaa gct tca cac aga gaa agg gag aaa gga aaa gaa aaa tta aaa        528
Thr Lys Ala Ser His Arg Glu Arg Glu Lys Gly Lys Glu Lys Leu Lys           
                165                 170                 175               

gga gaa aaa cct gag aag aca gca act cac aaa gag aaa ctt gag aaa        576
Gly Glu Lys Pro Glu Lys Thr Ala Thr His Lys Glu Lys Leu Glu Lys           
            180                 185                 190                   

aaa gaa aga cca gag acg aag atg atg gca aaa gag gac aag aaa att        624
Lys Glu Arg Pro Glu Thr Lys Met Met Ala Lys Glu Asp Lys Lys Ile           
        195                 200                 205                       

aag act aag gaa aag act gaa gaa aag gct aag aag gaa atg aaa gtt        672
Lys Thr Lys Glu Lys Thr Glu Glu Lys Ala Lys Lys Glu Met Lys Val           
    210                 215                 220                           

gga aaa cag gag aaa gtg aaa cca aca gct gca aaa gcc aaa gaa act        720
Gly Lys Gln Glu Lys Val Lys Pro Thr Ala Ala Lys Ala Lys Glu Thr           
225                 230                 235                 240           

ccg aaa aca cca cca aag gcc aga aag aag gat gac aaa gag atg cca        768
Pro Lys Thr Pro Pro Lys Ala Arg Lys Lys Asp Asp Lys Glu Met Pro           
                245                 250                 255               

gct gtg cat gag cag aaa ggt aaa cat tcc agg agg agg aga cag cag        816
Ala Val His Glu Gln Lys Gly Lys His Ser Arg Arg Arg Arg Gln Gln           
            260                 265                 270                   

gag gtc caa aga gaa taa                                                834
Glu Val Gln Arg Glu                                                       
        275                                                               


<210>  8
<211>  277
<212>  PRT
<213>  Mus musculus

<400>  8

Met Thr Glu Ile Thr Ala Glu Gly Asn Ala Ser Thr Thr Thr Thr Val 
1               5                   10                  15      


Ile Asp Asn Lys Asn Gly Cys Ile Pro Lys Ser Pro Gly Lys Val Leu 
            20                  25                  30          


Lys Lys Ser Val Thr Glu Asp Ile Val Thr Thr Phe Ser Ser Pro Ala 
        35                  40                  45              


Ala Trp Leu Leu Val Ile Ala Leu Ile Ile Thr Trp Ser Ala Val Ala 
    50                  55                  60                  


Ile Val Met Phe Asp Leu Val Asp Tyr Lys Asn Phe Ser Ala Ser Ser 
65                  70                  75                  80  


Ile Ala Lys Ile Gly Ser Asp Pro Leu Lys Leu Val Asn Asp Ala Val 
                85                  90                  95      


Glu Glu Thr Thr Asp Trp Ile Tyr Gly Phe Phe Ser Leu Leu Ser Asp 
            100                 105                 110         


Ile Ile Ser Ser Glu Gly Asp Glu Asp Asp Glu Asp Ala Asp Glu Asp 
        115                 120                 125             


Ile Asp Lys Gly Glu Ile Glu Glu Pro Pro Leu Lys Arg Lys Glu Ile 
    130                 135                 140                 


His Gln Glu Lys Ala Glu Lys Glu Glu Lys Pro Glu Lys Lys Ile Gln 
145                 150                 155                 160 


Thr Lys Ala Ser His Arg Glu Arg Glu Lys Gly Lys Glu Lys Leu Lys 
                165                 170                 175     


Gly Glu Lys Pro Glu Lys Thr Ala Thr His Lys Glu Lys Leu Glu Lys 
            180                 185                 190         


Lys Glu Arg Pro Glu Thr Lys Met Met Ala Lys Glu Asp Lys Lys Ile 
        195                 200                 205             


Lys Thr Lys Glu Lys Thr Glu Glu Lys Ala Lys Lys Glu Met Lys Val 
    210                 215                 220                 


Gly Lys Gln Glu Lys Val Lys Pro Thr Ala Ala Lys Ala Lys Glu Thr 
225                 230                 235                 240 


Pro Lys Thr Pro Pro Lys Ala Arg Lys Lys Asp Asp Lys Glu Met Pro 
                245                 250                 255     


Ala Val His Glu Gln Lys Gly Lys His Ser Arg Arg Arg Arg Gln Gln 
            260                 265                 270         


Glu Val Gln Arg Glu 
        275         


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat triadin forward primer

<400>  9
agccaaagaa actccgaaaa                                                   20


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat triadin reverse primer

<400>  10
tccagtggcc gtatgtactt c                                                 21


<210>  11
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse GAPDH forward primer

<400>  11
cgtgccgcct ggagaaac                                                     18


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse GAPDH reverse primer

<400>  12
tgggagttgc tgttgaagtc g                                                 21


<210>  13
<211>  864
<212>  DNA
<213>  Rattus norvegicus


<220>
<221>  CDS
<222>  (1)..(864)

<400>  13
atg act gag atc aca gct gaa gga aat gca tct ata acc aca act gtg         48
Met Thr Glu Ile Thr Ala Glu Gly Asn Ala Ser Ile Thr Thr Thr Val           
1               5                   10                  15                

ata gac aac aaa aat gga tct gtt ccc aag tcc cct gga aag gtg ctg         96
Ile Asp Asn Lys Asn Gly Ser Val Pro Lys Ser Pro Gly Lys Val Leu           
            20                  25                  30                    

aag agg act gtc acc gaa gac atc gtg aca aca ttc agc tcc cct gca        144
Lys Arg Thr Val Thr Glu Asp Ile Val Thr Thr Phe Ser Ser Pro Ala           
        35                  40                  45                        

gcc tgg ctt ctg gtc atc gcc ctg att atc acc tgg tca gct gtt gct        192
Ala Trp Leu Leu Val Ile Ala Leu Ile Ile Thr Trp Ser Ala Val Ala           
    50                  55                  60                            

att gtg atg ttt gat tta gtg gac tac aaa aac ttt tca gca agc tcc        240
Ile Val Met Phe Asp Leu Val Asp Tyr Lys Asn Phe Ser Ala Ser Ser           
65                  70                  75                  80            

atc gcc aag att ggc tct gat cct cta aaa cta gtg aac gat gct gtg        288
Ile Ala Lys Ile Gly Ser Asp Pro Leu Lys Leu Val Asn Asp Ala Val           
                85                  90                  95                

gag gaa aca aca gac tgg atc tat ggc ttc ttc tct ttg cta tct gat        336
Glu Glu Thr Thr Asp Trp Ile Tyr Gly Phe Phe Ser Leu Leu Ser Asp           
            100                 105                 110                   

atc atc tca tct gat ggt gat gaa gat gat gag gat gca gat gag gac        384
Ile Ile Ser Ser Asp Gly Asp Glu Asp Asp Glu Asp Ala Asp Glu Asp           
        115                 120                 125                       

att gac aaa gga gaa ata gaa gaa cct ccc tta aaa aga aaa gaa ata        432
Ile Asp Lys Gly Glu Ile Glu Glu Pro Pro Leu Lys Arg Lys Glu Ile           
    130                 135                 140                           

caa aaa gag aag gct gaa aag cag gag aaa cct gag aag aaa ata caa        480
Gln Lys Glu Lys Ala Glu Lys Gln Glu Lys Pro Glu Lys Lys Ile Gln           
145                 150                 155                 160           

act aaa gtt tcg cac aga gaa aag gag aaa gga aaa gaa aaa tta aaa        528
Thr Lys Val Ser His Arg Glu Lys Glu Lys Gly Lys Glu Lys Leu Lys           
                165                 170                 175               

gga gaa aaa cct gag aag aaa gca act cac aag gag aaa ctt gag aaa        576
Gly Glu Lys Pro Glu Lys Lys Ala Thr His Lys Glu Lys Leu Glu Lys           
            180                 185                 190                   

aaa gaa aga aca gag aca aag atg gca gca aaa gag gac aag aaa att        624
Lys Glu Arg Thr Glu Thr Lys Met Ala Ala Lys Glu Asp Lys Lys Ile           
        195                 200                 205                       

aag act aag gaa aag acc gaa gaa aag gct aag aag gaa atg aaa gtt        672
Lys Thr Lys Glu Lys Thr Glu Glu Lys Ala Lys Lys Glu Met Lys Val           
    210                 215                 220                           

ggg aaa cag gag aaa gcg aaa cca gca gct gca aaa gcc aaa gaa act        720
Gly Lys Gln Glu Lys Ala Lys Pro Ala Ala Ala Lys Ala Lys Glu Thr           
225                 230                 235                 240           

ccg aaa aca aca ccg aaa gcc aga gag aag gat gac aaa gaa acg cca        768
Pro Lys Thr Thr Pro Lys Ala Arg Glu Lys Asp Asp Lys Glu Thr Pro           
                245                 250                 255               

gct gtg ccc aag cat gag cag aaa ggt aaa ctt tcc aag gag gag aag        816
Ala Val Pro Lys His Glu Gln Lys Gly Lys Leu Ser Lys Glu Glu Lys           
            260                 265                 270                   

gag gca gta gga ggt cct aaa aga ata ttg gac aag aag cag ata tag        864
Glu Ala Val Gly Gly Pro Lys Arg Ile Leu Asp Lys Lys Gln Ile               
        275                 280                 285                       


<210>  14
<211>  287
<212>  PRT
<213>  Rattus norvegicus

<400>  14

Met Thr Glu Ile Thr Ala Glu Gly Asn Ala Ser Ile Thr Thr Thr Val 
1               5                   10                  15      


Ile Asp Asn Lys Asn Gly Ser Val Pro Lys Ser Pro Gly Lys Val Leu 
            20                  25                  30          


Lys Arg Thr Val Thr Glu Asp Ile Val Thr Thr Phe Ser Ser Pro Ala 
        35                  40                  45              


Ala Trp Leu Leu Val Ile Ala Leu Ile Ile Thr Trp Ser Ala Val Ala 
    50                  55                  60                  


Ile Val Met Phe Asp Leu Val Asp Tyr Lys Asn Phe Ser Ala Ser Ser 
65                  70                  75                  80  


Ile Ala Lys Ile Gly Ser Asp Pro Leu Lys Leu Val Asn Asp Ala Val 
                85                  90                  95      


Glu Glu Thr Thr Asp Trp Ile Tyr Gly Phe Phe Ser Leu Leu Ser Asp 
            100                 105                 110         


Ile Ile Ser Ser Asp Gly Asp Glu Asp Asp Glu Asp Ala Asp Glu Asp 
        115                 120                 125             


Ile Asp Lys Gly Glu Ile Glu Glu Pro Pro Leu Lys Arg Lys Glu Ile 
    130                 135                 140                 


Gln Lys Glu Lys Ala Glu Lys Gln Glu Lys Pro Glu Lys Lys Ile Gln 
145                 150                 155                 160 


Thr Lys Val Ser His Arg Glu Lys Glu Lys Gly Lys Glu Lys Leu Lys 
                165                 170                 175     


Gly Glu Lys Pro Glu Lys Lys Ala Thr His Lys Glu Lys Leu Glu Lys 
            180                 185                 190         


Lys Glu Arg Thr Glu Thr Lys Met Ala Ala Lys Glu Asp Lys Lys Ile 
        195                 200                 205             


Lys Thr Lys Glu Lys Thr Glu Glu Lys Ala Lys Lys Glu Met Lys Val 
    210                 215                 220                 


Gly Lys Gln Glu Lys Ala Lys Pro Ala Ala Ala Lys Ala Lys Glu Thr 
225                 230                 235                 240 


Pro Lys Thr Thr Pro Lys Ala Arg Glu Lys Asp Asp Lys Glu Thr Pro 
                245                 250                 255     


Ala Val Pro Lys His Glu Gln Lys Gly Lys Leu Ser Lys Glu Glu Lys 
            260                 265                 270         


Glu Ala Val Gly Gly Pro Lys Arg Ile Leu Asp Lys Lys Gln Ile 
        275                 280                 285         


<210>  15
<211>  861
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(861)

<400>  15
atg act gag atc act gct gaa gga aat gca tct aca acc aca act gtg         48
Met Thr Glu Ile Thr Ala Glu Gly Asn Ala Ser Thr Thr Thr Thr Val           
1               5                   10                  15                

ata gac agc aaa aat gga tct gtg ccc aaa tcc ccc gga aaa gtg ctg         96
Ile Asp Ser Lys Asn Gly Ser Val Pro Lys Ser Pro Gly Lys Val Leu           
            20                  25                  30                    

aag agg aca gtc aca gaa gac ata gtg acg acg ttc agc tcc cct gca        144
Lys Arg Thr Val Thr Glu Asp Ile Val Thr Thr Phe Ser Ser Pro Ala           
        35                  40                  45                        

gcc tgg ctt ctg gtc att gcc ctg ata atc acg tgg tca gct gtt gcc        192
Ala Trp Leu Leu Val Ile Ala Leu Ile Ile Thr Trp Ser Ala Val Ala           
    50                  55                  60                            

atc gtt atg ttt gat tta gtg gat tac aaa aac ttt tca gca agc tct        240
Ile Val Met Phe Asp Leu Val Asp Tyr Lys Asn Phe Ser Ala Ser Ser           
65                  70                  75                  80            

att gcc aag att ggc tca gat cct tta aaa ctg gta cgt gat gct atg        288
Ile Ala Lys Ile Gly Ser Asp Pro Leu Lys Leu Val Arg Asp Ala Met           
                85                  90                  95                

gag gaa acc acg gac tgg atc tat ggc ttc ttt tct ttg tta tct gac        336
Glu Glu Thr Thr Asp Trp Ile Tyr Gly Phe Phe Ser Leu Leu Ser Asp           
            100                 105                 110                   

atc atc tca tct gaa gat gaa gaa gat gat gat ggt gac gaa gat act        384
Ile Ile Ser Ser Glu Asp Glu Glu Asp Asp Asp Gly Asp Glu Asp Thr           
        115                 120                 125                       

gat aaa gga gaa ata gat gag cct ccc ttg aga aaa aaa gaa ata cac        432
Asp Lys Gly Glu Ile Asp Glu Pro Pro Leu Arg Lys Lys Glu Ile His           
    130                 135                 140                           

aaa gat aag act gaa aaa caa gag aaa cct gaa agg aaa ata caa act        480
Lys Asp Lys Thr Glu Lys Gln Glu Lys Pro Glu Arg Lys Ile Gln Thr           
145                 150                 155                 160           

aaa gtt aca cac aaa gaa aaa gaa aaa gga aaa gaa aaa gta aga gaa        528
Lys Val Thr His Lys Glu Lys Glu Lys Gly Lys Glu Lys Val Arg Glu           
                165                 170                 175               

aaa gaa aaa cct gaa aag aaa gca act cac aag gaa aaa att gag aaa        576
Lys Glu Lys Pro Glu Lys Lys Ala Thr His Lys Glu Lys Ile Glu Lys           
            180                 185                 190                   

aaa gaa aaa cca gaa aca aag aca gtg gcg aaa gaa cag aag aaa gct        624
Lys Glu Lys Pro Glu Thr Lys Thr Val Ala Lys Glu Gln Lys Lys Ala           
        195                 200                 205                       

aag act gca gaa aag agt gaa gaa aag act aaa aag gaa gtg aaa ggt        672
Lys Thr Ala Glu Lys Ser Glu Glu Lys Thr Lys Lys Glu Val Lys Gly           
    210                 215                 220                           

gga aaa cag gag aaa gtg aag caa aca gct gca aaa gta aaa gaa gta        720
Gly Lys Gln Glu Lys Val Lys Gln Thr Ala Ala Lys Val Lys Glu Val           
225                 230                 235                 240           

cag aaa aca cca tca aaa ccc aaa gaa aag gag gac aaa gag aaa gca        768
Gln Lys Thr Pro Ser Lys Pro Lys Glu Lys Glu Asp Lys Glu Lys Ala           
                245                 250                 255               

gct gtg tca aag cat gaa cag aaa ggt aaa cat tca gag cag gag gct        816
Ala Val Ser Lys His Glu Gln Lys Gly Lys His Ser Glu Gln Glu Ala           
            260                 265                 270                   

gcc gga ggt tct aag aga ata ttg ggc aag aag cac atg cag tga            861
Ala Gly Gly Ser Lys Arg Ile Leu Gly Lys Lys His Met Gln                   
        275                 280                 285                       


<210>  16
<211>  286
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Thr Glu Ile Thr Ala Glu Gly Asn Ala Ser Thr Thr Thr Thr Val 
1               5                   10                  15      


Ile Asp Ser Lys Asn Gly Ser Val Pro Lys Ser Pro Gly Lys Val Leu 
            20                  25                  30          


Lys Arg Thr Val Thr Glu Asp Ile Val Thr Thr Phe Ser Ser Pro Ala 
        35                  40                  45              


Ala Trp Leu Leu Val Ile Ala Leu Ile Ile Thr Trp Ser Ala Val Ala 
    50                  55                  60                  


Ile Val Met Phe Asp Leu Val Asp Tyr Lys Asn Phe Ser Ala Ser Ser 
65                  70                  75                  80  


Ile Ala Lys Ile Gly Ser Asp Pro Leu Lys Leu Val Arg Asp Ala Met 
                85                  90                  95      


Glu Glu Thr Thr Asp Trp Ile Tyr Gly Phe Phe Ser Leu Leu Ser Asp 
            100                 105                 110         


Ile Ile Ser Ser Glu Asp Glu Glu Asp Asp Asp Gly Asp Glu Asp Thr 
        115                 120                 125             


Asp Lys Gly Glu Ile Asp Glu Pro Pro Leu Arg Lys Lys Glu Ile His 
    130                 135                 140                 


Lys Asp Lys Thr Glu Lys Gln Glu Lys Pro Glu Arg Lys Ile Gln Thr 
145                 150                 155                 160 


Lys Val Thr His Lys Glu Lys Glu Lys Gly Lys Glu Lys Val Arg Glu 
                165                 170                 175     


Lys Glu Lys Pro Glu Lys Lys Ala Thr His Lys Glu Lys Ile Glu Lys 
            180                 185                 190         


Lys Glu Lys Pro Glu Thr Lys Thr Val Ala Lys Glu Gln Lys Lys Ala 
        195                 200                 205             


Lys Thr Ala Glu Lys Ser Glu Glu Lys Thr Lys Lys Glu Val Lys Gly 
    210                 215                 220                 


Gly Lys Gln Glu Lys Val Lys Gln Thr Ala Ala Lys Val Lys Glu Val 
225                 230                 235                 240 


Gln Lys Thr Pro Ser Lys Pro Lys Glu Lys Glu Asp Lys Glu Lys Ala 
                245                 250                 255     


Ala Val Ser Lys His Glu Gln Lys Gly Lys His Ser Glu Gln Glu Ala 
            260                 265                 270         


Ala Gly Gly Ser Lys Arg Ile Leu Gly Lys Lys His Met Gln 
        275                 280                 285     


