SEQUENCE LISTING

<110>   KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN

<120>   Culture medium

<130>   P064831WO

<141>   2015-11-27

<150>   GB1421094.2
<151>   2014-11-27

<160>   33

<170>   SeqWin2010, version 1.0

<210>   1
<211>   607
<212>   PRT
<213>   Homo sapiens

<400>   1
Met Gly Lys Gly Arg Ala Gly Arg Val Gly Thr Thr Ala Leu Pro Pro 
1               5                   10                  15      

Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala Ala Gly Ser Lys Leu 
            20                  25                  30          

Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser Ser Leu Arg Phe Lys 
        35                  40                  45              

Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys Asn Lys Pro Gln Asn 
    50                  55                  60                  

Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu Leu Arg Ile Asn Lys 
65                  70                  75                  80  

Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys Lys Val Ile Ser Lys 
                85                  90                  95      

Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr Ile Val Glu Ser Asn 
            100                 105                 110         

Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu Gly Ala Tyr Val Ser 
        115                 120                 125             

Ser Ala Thr Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys 
    130                 135                 140                 

Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met 
145                 150                 155                 160 

Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn 
                165                 170                 175     

Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr 
            180                 185                 190         

Lys His Leu Gly Ile Glu Phe Met Glu Ala Glu Glu Leu Tyr Gln Lys 
        195                 200                 205             

Arg Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly 
    210                 215                 220                 

Ile Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys 
225                 230                 235                 240 

Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met 
                245                 250                 255     

Met Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn 
            260                 265                 270         

Val Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu 
        275                 280                 285             

His Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr 
    290                 295                 300                 

Thr Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His 
305                 310                 315                 320 

Ser Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser 
                325                 330                 335     

Val Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr 
            340                 345                 350         

Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys 
        355                 360                 365             

Asn Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp 
    370                 375                 380                 

Ser Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala Arg 
385                 390                 395                 400 

Met Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro Pro 
                405                 410                 415     

Ser Glu Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro Ser 
            420                 425                 430         

Met Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu Val 
        435                 440                 445             

Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln Gln 
    450                 455                 460                 

Phe Ser Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu Pro 
465                 470                 475                 480 

Ala Ser Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr Gln 
                485                 490                 495     

Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser Arg 
            500                 505                 510         

Arg Ala Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu Glu 
        515                 520                 525             

Val Asp Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu Thr 
    530                 535                 540                 

Glu Asp Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln Asn 
545                 550                 555                 560 

Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala Asp 
                565                 570                 575     

Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile Gln 
            580                 585                 590         

Ala Arg Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
        595                 600                 605         

<210>   2
<211>   308
<212>   PRT
<213>   Homo sapiens

<400>   2
Met Gln Ile Pro Lys His Ile Ser Ile Glu Asp Ile Thr Ala Thr Ser 
1               5                   10                  15      

Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys Glu 
            20                  25                  30          

Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp Leu 
        35                  40                  45              

Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Gln Pro Gly Phe Thr Gly 
    50                  55                  60                  

Ala Arg Cys Thr Glu Asn Val Pro Met Lys Val Gln Asn Gln Glu Lys 
65                  70                  75                  80  

Ala Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly Ile Cys 
                85                  90                  95      

Ile Ala Leu Leu Val Val Gly Ile Met Cys Val Val Ala Tyr Cys Lys 
            100                 105                 110         

Thr Lys Lys Gln Arg Lys Lys Leu His Asp Arg Leu Arg Gln Ser Leu 
        115                 120                 125             

Arg Ser Glu Arg Asn Asn Met Met Asn Ile Ala Asn Gly Pro His His 
    130                 135                 140                 

Pro Asn Pro Pro Pro Glu Asn Val Gln Leu Val Asn Gln Tyr Val Ser 
145                 150                 155                 160 

Lys Asn Val Ile Ser Ser Glu His Ile Val Glu Arg Glu Ala Glu Thr 
                165                 170                 175     

Ser Phe Ser Thr Ser His Tyr Thr Ser Thr Ala His His Ser Thr Thr 
            180                 185                 190         

Val Thr Gln Thr Pro Ser His Ser Trp Ser Asn Gly His Thr Glu Ser 
        195                 200                 205             

Ile Leu Ser Glu Ser His Ser Val Ile Val Met Ser Ser Val Glu Asn 
    210                 215                 220                 

Ser Arg His Ser Ser Pro Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly 
225                 230                 235                 240 

Thr Gly Gly Pro Arg Glu Cys Asn Ser Phe Leu Arg His Ala Arg Glu 
                245                 250                 255     

Thr Pro Asp Ser Tyr Arg Asp Ser Pro His Ser Glu Arg His Asn Leu 
            260                 265                 270         

Ile Ala Glu Leu Arg Arg Asn Lys Ala His Arg Ser Lys Cys Met Gln 
        275                 280                 285             

Ile Gln Leu Ser Ala Thr His Leu Arg Ser Ser Ser Ile Pro His Leu 
    290                 295                 300                 

Gly Phe Ile Leu 
305             

<210>   3
<211>   624
<212>   PRT
<213>   Homo sapiens

<400>   3
Met Gly Lys Gly Arg Ala Gly Arg Val Gly Thr Thr Ala Leu Pro Pro 
1               5                   10                  15      

Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala Ala Gly Ser Lys Leu 
            20                  25                  30          

Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser Ser Leu Arg Phe Lys 
        35                  40                  45              

Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys Asn Lys Pro Gln Asn 
    50                  55                  60                  

Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu Leu Arg Ile Asn Lys 
65                  70                  75                  80  

Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys Lys Val Ile Ser Lys 
                85                  90                  95      

Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr Ile Val Glu Ser Asn 
            100                 105                 110         

Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu Gly Ala Tyr Val Ser 
        115                 120                 125             

Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr Glu Gly Ala Asn Thr 
    130                 135                 140                 

Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys 
145                 150                 155                 160 

Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe 
                165                 170                 175     

Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro 
            180                 185                 190         

Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe 
        195                 200                 205             

Tyr Lys His Leu Gly Ile Glu Phe Met Glu Ala Glu Glu Leu Tyr Gln 
    210                 215                 220                 

Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val 
225                 230                 235                 240 

Gly Ile Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys 
                245                 250                 255     

Lys Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn 
            260                 265                 270         

Met Met Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu 
        275                 280                 285             

Asn Val Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser 
    290                 295                 300                 

Glu His Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His 
305                 310                 315                 320 

Tyr Thr Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser 
                325                 330                 335     

His Ser Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His 
            340                 345                 350         

Ser Val Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro 
        355                 360                 365             

Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu 
    370                 375                 380                 

Cys Asn Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg 
385                 390                 395                 400 

Asp Ser Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala 
                405                 410                 415     

Arg Met Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro 
            420                 425                 430         

Pro Ser Glu Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro 
        435                 440                 445             

Ser Met Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu 
    450                 455                 460                 

Val Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln 
465                 470                 475                 480 

Gln Phe Ser Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu 
                485                 490                 495     

Pro Ala Ser Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr 
            500                 505                 510         

Gln Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser 
        515                 520                 525             

Arg Arg Ala Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu 
    530                 535                 540                 

Glu Val Asp Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu 
545                 550                 555                 560 

Thr Glu Asp Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln 
                565                 570                 575     

Asn Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala 
            580                 585                 590         

Asp Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile 
        595                 600                 605             

Gln Ala Arg Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
    610                 615                 620                 

<210>   4
<211>   590
<212>   PRT
<213>   Homo sapiens

<400>   4
Met Gly Lys Gly Arg Ala Gly Arg Val Gly Thr Thr Ala Leu Pro Pro 
1               5                   10                  15      

Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala Ala Gly Ser Lys Leu 
            20                  25                  30          

Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser Ser Leu Arg Phe Lys 
        35                  40                  45              

Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys Asn Lys Pro Gln Asn 
    50                  55                  60                  

Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu Leu Arg Ile Asn Lys 
65                  70                  75                  80  

Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys Lys Val Ile Ser Lys 
                85                  90                  95      

Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr Ile Val Glu Ser Asn 
            100                 105                 110         

Ala Thr Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala 
        115                 120                 125             

Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val 
    130                 135                 140                 

Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu 
145                 150                 155                 160 

Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr Lys 
                165                 170                 175     

His Leu Gly Ile Glu Phe Met Glu Ala Glu Glu Leu Tyr Gln Lys Arg 
            180                 185                 190         

Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly Ile 
        195                 200                 205             

Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys Leu 
    210                 215                 220                 

His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met Met 
225                 230                 235                 240 

Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn Val 
                245                 250                 255     

Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu His 
            260                 265                 270         

Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr Thr 
        275                 280                 285             

Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His Ser 
    290                 295                 300                 

Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser Val 
305                 310                 315                 320 

Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr Gly 
                325                 330                 335     

Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys Asn 
            340                 345                 350         

Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp Ser 
        355                 360                 365             

Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala Arg Met 
    370                 375                 380                 

Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro Pro Ser 
385                 390                 395                 400 

Glu Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro Ser Met 
                405                 410                 415     

Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu Val Thr 
            420                 425                 430         

Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln Gln Phe 
        435                 440                 445             

Ser Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu Pro Ala 
    450                 455                 460                 

Ser Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr Gln Glu 
465                 470                 475                 480 

Tyr Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser Arg Arg 
                485                 490                 495     

Ala Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu Glu Val 
            500                 505                 510         

Asp Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu Thr Glu 
        515                 520                 525             

Asp Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln Asn Pro 
    530                 535                 540                 

Leu Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala Asp Ser 
545                 550                 555                 560 

Arg Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile Gln Ala 
                565                 570                 575     

Arg Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
            580                 585                 590 

<210>   5
<211>   194
<212>   PRT
<213>   Homo sapiens

<400>   5
Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      

Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          

Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              

Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  

Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  

Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      

Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         

Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             

Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 

Gly Ala Tyr Val Ser Ser Ala Thr Ser Thr Ser Thr Thr Gly Thr Ser 
145                 150                 155                 160 

His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly 
                165                 170                 175     

Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu 
            180                 185                 190         

Cys Lys 
        

<210>   6
<211>   459
<212>   PRT
<213>   Homo sapiens

<400>   6
Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      

Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          

Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              

Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  

Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  

Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      

Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         

Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             

Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 

Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 

Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     

Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         

Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             

Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
    210                 215                 220                 

Val Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Lys Arg Val 
225                 230                 235                 240 

Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly Ile Met 
                245                 250                 255     

Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys Leu His 
            260                 265                 270         

Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met Met Asn 
        275                 280                 285             

Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn Val Gln 
    290                 295                 300                 

Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu His Ile 
305                 310                 315                 320 

Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr Thr Ser 
                325                 330                 335     

Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His Ser Trp 
            340                 345                 350         

Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser Val Ile 
        355                 360                 365             

Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr Gly Gly 
    370                 375                 380                 

Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys Asn Ser 
385                 390                 395                 400 

Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp Ser Pro 
                405                 410                 415     

His Ser Glu Arg His Asn Leu Ile Ala Glu Leu Arg Arg Asn Lys Ala 
            420                 425                 430         

His Arg Ser Lys Cys Met Gln Ile Gln Leu Ser Ala Thr His Leu Arg 
        435                 440                 445             

Ser Ser Ser Ile Pro His Leu Gly Phe Ile Leu 
    450                 455                 

<210>   7
<211>   207
<212>   PRT
<213>   Homo sapiens

<400>   7
Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      

Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          

Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              

Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  

Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  

Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      

Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         

Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             

Ile Val Glu Ser Asn Ala Thr Ser Thr Ser Thr Thr Gly Thr Ser His 
    130                 135                 140                 

Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly 
145                 150                 155                 160 

Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys 
                165                 170                 175     

Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val Met 
            180                 185                 190         

Ala Ser Phe Tyr Ser Thr Ser Thr Pro Phe Leu Ser Leu Pro Glu 
        195                 200                 205         

<210>   8
<211>   177
<212>   PRT
<213>   Homo sapiens

<400>   8
Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      

Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          

Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              

Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  

Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  

Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      

Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         

Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             

Ile Val Glu Ser Asn Ala Thr Ser Thr Ser Thr Thr Gly Thr Ser His 
    130                 135                 140                 

Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly 
145                 150                 155                 160 

Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys 
                165                 170                 175     

Lys 
    

<210>   9
<211>   420
<212>   PRT
<213>   Homo sapiens

<400>   9
Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      

Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          

Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              

Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  

Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  

Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      

Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         

Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             

Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 

Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 

Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     

Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         

Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             

Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
    210                 215                 220                 

Val Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Lys Arg Val 
225                 230                 235                 240 

Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly Ile Met 
                245                 250                 255     

Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys Leu His 
            260                 265                 270         

Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met Met Asn 
        275                 280                 285             

Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn Val Gln 
    290                 295                 300                 

Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu His Ile 
305                 310                 315                 320 

Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr Thr Ser 
                325                 330                 335     

Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His Ser Trp 
            340                 345                 350         

Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser Val Ile 
        355                 360                 365             

Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr Gly Gly 
    370                 375                 380                 

Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys Asn Ser 
385                 390                 395                 400 

Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp Ser Pro 
                405                 410                 415     

His Ser Glu Arg 
            420 

<210>   10
<211>   211
<212>   PRT
<213>   Homo sapiens

<400>   10
Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      

Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          

Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              

Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  

Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  

Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      

Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         

Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             

Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 

Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 

Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     

Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         

Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             

Leu Cys Lys 
    210     

<210>   11
<211>   645
<212>   PRT
<213>   Homo sapiens

<400>   11
Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      

Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          

Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              

Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  

Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  

Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      

Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         

Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             

Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 

Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 

Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     

Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         

Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             

Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
    210                 215                 220                 

Val Met Ala Ser Phe Tyr Lys His Leu Gly Ile Glu Phe Met Glu Ala 
225                 230                 235                 240 

Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Ile 
                245                 250                 255     

Ala Leu Leu Val Val Gly Ile Met Cys Val Val Ala Tyr Cys Lys Thr 
            260                 265                 270         

Lys Lys Gln Arg Lys Lys Leu His Asp Arg Leu Arg Gln Ser Leu Arg 
        275                 280                 285             

Ser Glu Arg Asn Asn Met Met Asn Ile Ala Asn Gly Pro His His Pro 
    290                 295                 300                 

Asn Pro Pro Pro Glu Asn Val Gln Leu Val Asn Gln Tyr Val Ser Lys 
305                 310                 315                 320 

Asn Val Ile Ser Ser Glu His Ile Val Glu Arg Glu Ala Glu Thr Ser 
                325                 330                 335     

Phe Ser Thr Ser His Tyr Thr Ser Thr Ala His His Ser Thr Thr Val 
            340                 345                 350         

Thr Gln Thr Pro Ser His Ser Trp Ser Asn Gly His Thr Glu Ser Ile 
        355                 360                 365             

Leu Ser Glu Ser His Ser Val Ile Val Met Ser Ser Val Glu Asn Ser 
    370                 375                 380                 

Arg His Ser Ser Pro Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr 
385                 390                 395                 400 

Gly Gly Pro Arg Glu Cys Asn Ser Phe Leu Arg His Ala Arg Glu Thr 
                405                 410                 415     

Pro Asp Ser Tyr Arg Asp Ser Pro His Ser Glu Arg Tyr Val Ser Ala 
            420                 425                 430         

Met Thr Thr Pro Ala Arg Met Ser Pro Val Asp Phe His Thr Pro Ser 
        435                 440                 445             

Ser Pro Lys Ser Pro Pro Ser Glu Met Ser Pro Pro Val Ser Ser Met 
    450                 455                 460                 

Thr Val Ser Met Pro Ser Met Ala Val Ser Pro Phe Met Glu Glu Glu 
465                 470                 475                 480 

Arg Pro Leu Leu Leu Val Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe 
                485                 490                 495     

Asp His His Pro Gln Gln Phe Ser Ser Phe His His Asn Pro Ala His 
            500                 505                 510         

Asp Ser Asn Ser Leu Pro Ala Ser Pro Leu Arg Ile Val Glu Asp Glu 
        515                 520                 525             

Glu Tyr Glu Thr Thr Gln Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys 
    530                 535                 540                 

Lys Leu Ala Asn Ser Arg Arg Ala Lys Arg Thr Lys Pro Asn Gly His 
545                 550                 555                 560 

Ile Ala Asn Arg Leu Glu Val Asp Ser Asn Thr Ser Ser Gln Ser Ser 
                565                 570                 575     

Asn Ser Glu Ser Glu Thr Glu Asp Glu Arg Val Gly Glu Asp Thr Pro 
            580                 585                 590         

Phe Leu Gly Ile Gln Asn Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro 
        595                 600                 605             

Ala Phe Arg Leu Ala Asp Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser 
    610                 615                 620                 

Thr Gln Glu Glu Ile Gln Ala Arg Leu Ser Ser Val Ile Ala Asn Gln 
625                 630                 635                 640 

Asp Pro Ile Ala Val 
                645 

<210>   12
<211>   637
<212>   PRT
<213>   Homo sapiens

<400>   12
Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      

Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          

Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              

Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  

Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  

Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      

Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         

Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             

Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 

Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 

Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     

Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         

Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             

Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
    210                 215                 220                 

Val Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Lys Arg Val 
225                 230                 235                 240 

Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly Ile Met 
                245                 250                 255     

Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys Leu His 
            260                 265                 270         

Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met Met Asn 
        275                 280                 285             

Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn Val Gln 
    290                 295                 300                 

Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu His Ile 
305                 310                 315                 320 

Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr Thr Ser 
                325                 330                 335     

Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His Ser Trp 
            340                 345                 350         

Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser Val Ile 
        355                 360                 365             

Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr Gly Gly 
    370                 375                 380                 

Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys Asn Ser 
385                 390                 395                 400 

Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp Ser Pro 
                405                 410                 415     

His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala Arg Met Ser 
            420                 425                 430         

Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro Pro Ser Glu 
        435                 440                 445             

Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro Ser Met Ala 
    450                 455                 460                 

Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu Val Thr Pro 
465                 470                 475                 480 

Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln Gln Phe Ser 
                485                 490                 495     

Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu Pro Ala Ser 
            500                 505                 510         

Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr Gln Glu Tyr 
        515                 520                 525             

Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser Arg Arg Ala 
    530                 535                 540                 

Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu Glu Val Asp 
545                 550                 555                 560 

Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu Thr Glu Asp 
                565                 570                 575     

Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln Asn Pro Leu 
            580                 585                 590         

Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala Asp Ser Arg 
        595                 600                 605             

Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile Gln Ala Arg 
    610                 615                 620                 

Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
625                 630                 635         

<210>   13
<211>   241
<212>   PRT
<213>   Homo sapiens

<400>   13
Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      

Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          

Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              

Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  

Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  

Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      

Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         

Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             

Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 

Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 

Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     

Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         

Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             

Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
    210                 215                 220                 

Val Met Ala Ser Phe Tyr Ser Thr Ser Thr Pro Phe Leu Ser Leu Pro 
225                 230                 235                 240 

Glu 
    

<210>   14
<211>   296
<212>   PRT
<213>   Homo sapiens

<400>   14
Met Glu Ile Tyr Ser Pro Asp Met Ser Glu Val Ala Ala Glu Arg Ser 
1               5                   10                  15      

Ser Ser Pro Ser Thr Gln Leu Ser Ala Asp Pro Ser Leu Asp Gly Leu 
            20                  25                  30          

Pro Ala Ala Glu Asp Met Pro Glu Pro Gln Thr Glu Asp Gly Arg Thr 
        35                  40                  45              

Pro Gly Leu Val Gly Leu Ala Val Pro Cys Cys Ala Cys Leu Glu Ala 
    50                  55                  60                  

Glu Arg Leu Arg Gly Cys Leu Asn Ser Glu Lys Ile Cys Ile Val Pro 
65                  70                  75                  80  

Ile Leu Ala Cys Leu Val Ser Leu Cys Leu Cys Ile Ala Gly Leu Lys 
                85                  90                  95      

Trp Val Phe Val Asp Lys Ile Phe Glu Tyr Asp Ser Pro Thr His Leu 
            100                 105                 110         

Asp Pro Gly Gly Leu Gly Gln Asp Pro Ile Ile Ser Leu Asp Ala Thr 
        115                 120                 125             

Ala Ala Ser Ala Val Trp Val Ser Ser Glu Ala Tyr Thr Ser Pro Val 
    130                 135                 140                 

Ser Arg Ala Gln Ser Glu Ser Glu Val Gln Val Thr Val Gln Gly Asp 
145                 150                 155                 160 

Lys Ala Val Val Ser Phe Glu Pro Ser Ala Ala Pro Thr Pro Lys Asn 
                165                 170                 175     

Arg Ile Phe Ala Phe Ser Phe Leu Pro Ser Thr Ala Pro Ser Phe Pro 
            180                 185                 190         

Ser Pro Thr Arg Asn Pro Glu Val Arg Thr Pro Lys Ser Ala Thr Gln 
        195                 200                 205             

Pro Gln Thr Thr Glu Thr Asn Leu Gln Thr Ala Pro Lys Leu Ser Thr 
    210                 215                 220                 

Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys 
225                 230                 235                 240 

Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp 
                245                 250                 255     

Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu Phe Thr 
            260                 265                 270         

Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr Ser Thr Ser 
        275                 280                 285             

Thr Pro Phe Leu Ser Leu Pro Glu 
    290                 295     

<210>   15
<211>   462
<212>   PRT
<213>   Homo sapiens

<400>   15
Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      

Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          

Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              

Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  

Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  

Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      

Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         

Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             

Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 

Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 

Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     

Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         

Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             

Leu Cys Lys Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys Thr Glu Asn 
    210                 215                 220                 

Val Pro Met Lys Val Gln Asn Gln Glu Lys Ala Glu Glu Leu Tyr Gln 
225                 230                 235                 240 

Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val 
                245                 250                 255     

Gly Ile Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys 
            260                 265                 270         

Lys Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn 
        275                 280                 285             

Met Met Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu 
    290                 295                 300                 

Asn Val Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser 
305                 310                 315                 320 

Glu His Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His 
                325                 330                 335     

Tyr Thr Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser 
            340                 345                 350         

His Ser Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His 
        355                 360                 365             

Ser Val Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro 
    370                 375                 380                 

Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu 
385                 390                 395                 400 

Cys Asn Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg 
                405                 410                 415     

Asp Ser Pro His Ser Glu Arg His Asn Leu Ile Ala Glu Leu Arg Arg 
            420                 425                 430         

Asn Lys Ala His Arg Ser Lys Cys Met Gln Ile Gln Leu Ser Ala Thr 
        435                 440                 445             

His Leu Arg Ser Ser Ser Ile Pro His Leu Gly Phe Ile Leu 
    450                 455                 460         

<210>   16
<211>   422
<212>   PRT
<213>   Homo sapiens

<400>   16
Met Arg Trp Arg Arg Ala Pro Arg Arg Ser Gly Arg Pro Gly Pro Arg 
1               5                   10                  15      

Ala Gln Arg Pro Gly Ser Ala Ala Arg Ser Ser Pro Pro Leu Pro Leu 
            20                  25                  30          

Leu Pro Leu Leu Leu Leu Leu Gly Thr Ala Ala Leu Ala Pro Gly Ala 
        35                  40                  45              

Ala Ala Gly Asn Glu Ala Ala Pro Ala Gly Ala Ser Val Cys Tyr Ser 
    50                  55                  60                  

Ser Pro Pro Ser Val Gly Ser Val Gln Glu Leu Ala Gln Arg Ala Ala 
65                  70                  75                  80  

Val Val Ile Glu Gly Lys Val His Pro Gln Arg Arg Gln Gln Gly Ala 
                85                  90                  95      

Leu Asp Arg Lys Ala Ala Ala Ala Ala Gly Glu Ala Gly Ala Trp Gly 
            100                 105                 110         

Gly Asp Arg Glu Pro Pro Ala Ala Gly Pro Arg Ala Leu Gly Pro Pro 
        115                 120                 125             

Ala Glu Glu Pro Leu Leu Ala Ala Asn Gly Thr Val Pro Ser Trp Pro 
    130                 135                 140                 

Thr Ala Pro Val Pro Ser Ala Gly Glu Pro Gly Glu Glu Ala Pro Tyr 
145                 150                 155                 160 

Leu Val Lys Val His Gln Val Trp Ala Val Lys Ala Gly Gly Leu Lys 
                165                 170                 175     

Lys Asp Ser Leu Leu Thr Val Arg Leu Gly Thr Trp Gly His Pro Ala 
            180                 185                 190         

Phe Pro Ser Cys Gly Arg Leu Lys Glu Asp Ser Arg Tyr Ile Phe Phe 
        195                 200                 205             

Met Glu Pro Asp Ala Asn Ser Thr Ser Arg Ala Pro Ala Ala Phe Arg 
    210                 215                 220                 

Ala Ser Phe Pro Pro Leu Glu Thr Gly Arg Asn Leu Lys Lys Glu Val 
225                 230                 235                 240 

Ser Arg Val Leu Cys Lys Arg Cys Ala Leu Pro Pro Arg Leu Lys Glu 
                245                 250                 255     

Met Lys Ser Gln Glu Ser Ala Ala Gly Ser Lys Leu Val Leu Arg Cys 
            260                 265                 270         

Glu Thr Ser Ser Glu Tyr Ser Ser Leu Arg Phe Lys Trp Phe Lys Asn 
        275                 280                 285             

Gly Asn Glu Leu Asn Arg Lys Asn Lys Pro Gln Asn Ile Lys Ile Gln 
    290                 295                 300                 

Lys Lys Pro Gly Lys Ser Glu Leu Arg Ile Asn Lys Ala Ser Leu Ala 
305                 310                 315                 320 

Asp Ser Gly Glu Tyr Met Cys Lys Val Ile Ser Lys Leu Gly Asn Asp 
                325                 330                 335     

Ser Ala Ser Ala Asn Ile Thr Ile Val Glu Ser Asn Ala Thr Ser Thr 
            340                 345                 350         

Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys 
        355                 360                 365             

Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser 
    370                 375                 380                 

Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp 
385                 390                 395                 400 

Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr Ser Thr Ser Thr Pro 
                405                 410                 415     

Phe Leu Ser Leu Pro Glu 
            420         

<210>   17
<211>   640
<212>   PRT
<213>   Homo sapiens

<400>   17
Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      

Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          

Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              

Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  

Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  

Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      

Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         

Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             

Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 

Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 

Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     

Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         

Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             

Leu Cys Lys Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys Thr Glu Asn 
    210                 215                 220                 

Val Pro Met Lys Val Gln Asn Gln Glu Lys Ala Glu Glu Leu Tyr Gln 
225                 230                 235                 240 

Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val 
                245                 250                 255     

Gly Ile Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys 
            260                 265                 270         

Lys Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn 
        275                 280                 285             

Met Met Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu 
    290                 295                 300                 

Asn Val Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser 
305                 310                 315                 320 

Glu His Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His 
                325                 330                 335     

Tyr Thr Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser 
            340                 345                 350         

His Ser Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His 
        355                 360                 365             

Ser Val Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro 
    370                 375                 380                 

Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu 
385                 390                 395                 400 

Cys Asn Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg 
                405                 410                 415     

Asp Ser Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala 
            420                 425                 430         

Arg Met Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro 
        435                 440                 445             

Pro Ser Glu Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro 
    450                 455                 460                 

Ser Met Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu 
465                 470                 475                 480 

Val Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln 
                485                 490                 495     

Gln Phe Ser Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu 
            500                 505                 510         

Pro Ala Ser Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr 
        515                 520                 525             

Gln Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser 
    530                 535                 540                 

Arg Arg Ala Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu 
545                 550                 555                 560 

Glu Val Asp Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu 
                565                 570                 575     

Thr Glu Asp Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln 
            580                 585                 590         

Asn Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala 
        595                 600                 605             

Asp Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile 
    610                 615                 620                 

Gln Ala Arg Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
625                 630                 635                 640 

<210>   18
<211>   784
<212>   PRT
<213>   Homo sapiens

<400>   18
Met Arg Gln Val Cys Cys Ser Ala Leu Pro Pro Pro Pro Leu Glu Lys 
1               5                   10                  15      

Gly Arg Cys Ser Ser Tyr Ser Asp Ser Ser Ser Ser Ser Ser Glu Arg 
            20                  25                  30          

Ser Ser Ser Ser Ser Ser Ser Ser Ser Glu Ser Gly Ser Ser Ser Arg 
        35                  40                  45              

Ser Ser Ser Asn Asn Ser Ser Ile Ser Arg Pro Ala Ala Pro Pro Glu 
    50                  55                  60                  

Pro Arg Pro Gln Gln Gln Pro Gln Pro Arg Ser Pro Ala Ala Arg Arg 
65                  70                  75                  80  

Ala Ala Ala Arg Ser Arg Ala Ala Ala Ala Gly Gly Met Arg Arg Asp 
                85                  90                  95      

Pro Ala Pro Gly Phe Ser Met Leu Leu Phe Gly Val Ser Leu Ala Cys 
            100                 105                 110         

Tyr Ser Pro Ser Leu Lys Ser Val Gln Asp Gln Ala Tyr Lys Ala Pro 
        115                 120                 125             

Val Val Val Glu Gly Lys Val Gln Gly Leu Val Pro Ala Gly Gly Ser 
    130                 135                 140                 

Ser Ser Asn Ser Thr Arg Glu Pro Pro Ala Ser Gly Arg Val Ala Leu 
145                 150                 155                 160 

Val Lys Val Leu Asp Lys Trp Pro Leu Arg Ser Gly Gly Leu Gln Arg 
                165                 170                 175     

Glu Gln Val Ile Ser Val Gly Ser Cys Val Pro Leu Glu Arg Asn Gln 
            180                 185                 190         

Arg Tyr Ile Phe Phe Leu Glu Pro Thr Glu Gln Pro Leu Val Phe Lys 
        195                 200                 205             

Thr Ala Phe Ala Pro Leu Asp Thr Asn Gly Lys Asn Leu Lys Lys Glu 
    210                 215                 220                 

Val Gly Lys Ile Leu Cys Thr Asp Cys Ala Thr Arg Pro Lys Leu Lys 
225                 230                 235                 240 

Lys Met Lys Ser Gln Thr Gly Gln Val Gly Glu Lys Gln Ser Leu Lys 
                245                 250                 255     

Cys Glu Ala Ala Ala Gly Asn Pro Gln Pro Ser Tyr Arg Trp Phe Lys 
            260                 265                 270         

Asp Gly Lys Glu Leu Asn Arg Ser Arg Asp Ile Arg Ile Lys Tyr Gly 
        275                 280                 285             

Asn Gly Arg Lys Asn Ser Arg Leu Gln Phe Asn Lys Val Lys Val Glu 
    290                 295                 300                 

Asp Ala Gly Glu Tyr Val Cys Glu Ala Glu Asn Ile Leu Gly Lys Asp 
305                 310                 315                 320 

Thr Val Arg Gly Arg Leu Tyr Val Asn Ser Glu Ala Glu Glu Leu Tyr 
                325                 330                 335     

Gln Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Val Ala Leu Leu Val 
            340                 345                 350         

Val Gly Ile Val Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg 
        355                 360                 365             

Lys Gln Met His Asn His Leu Arg Gln Asn Met Cys Pro Ala His Gln 
    370                 375                 380                 

Asn Arg Ser Leu Ala Asn Gly Pro Ser His Pro Arg Leu Asp Pro Glu 
385                 390                 395                 400 

Glu Ile Gln Met Ala Asp Tyr Ile Ser Lys Asn Val Pro Ala Thr Asp 
                405                 410                 415     

His Val Ile Arg Arg Glu Thr Glu Thr Thr Phe Ser Gly Ser His Ser 
            420                 425                 430         

Cys Ser Pro Ser His His Cys Ser Thr Ala Thr Pro Thr Ser Ser His 
        435                 440                 445             

Arg His Glu Ser His Thr Trp Ser Leu Glu Arg Ser Glu Ser Leu Thr 
    450                 455                 460                 

Ser Asp Ser Gln Ser Gly Ile Met Leu Ser Ser Val Gly Thr Ser Lys 
465                 470                 475                 480 

Cys Asn Ser Pro Ala Cys Val Glu Ala Arg Ala Arg Arg Ala Ala Ala 
                485                 490                 495     

Tyr Asn Leu Glu Glu Arg Arg Arg Ala Thr Ala Pro Pro Tyr His Asp 
            500                 505                 510         

Ser Val Asp Ser Leu Arg Asp Ser Pro His Ser Glu Arg Tyr Val Ser 
        515                 520                 525             

Ala Leu Thr Thr Pro Ala Arg Leu Ser Pro Val Asp Phe His Tyr Ser 
    530                 535                 540                 

Leu Ala Thr Gln Val Pro Thr Phe Glu Ile Thr Ser Pro Asn Ser Ala 
545                 550                 555                 560 

His Ala Val Ser Leu Pro Pro Ala Ala Pro Ile Ser Tyr Arg Leu Ala 
                565                 570                 575     

Glu Gln Gln Pro Leu Leu Arg His Pro Ala Pro Pro Gly Pro Gly Pro 
            580                 585                 590         

Gly Pro Gly Pro Gly Pro Gly Pro Gly Ala Asp Met Gln Arg Ser Tyr 
        595                 600                 605             

Asp Ser Tyr Tyr Tyr Pro Ala Ala Gly Pro Gly Pro Arg Arg Gly Thr 
    610                 615                 620                 

Cys Ala Leu Gly Gly Ser Leu Gly Ser Leu Pro Ala Ser Pro Phe Arg 
625                 630                 635                 640 

Ile Pro Glu Asp Asp Glu Tyr Glu Thr Thr Gln Glu Cys Ala Pro Pro 
                645                 650                 655     

Pro Pro Pro Arg Pro Arg Ala Arg Gly Ala Ser Arg Arg Thr Ser Ala 
            660                 665                 670         

Gly Pro Arg Arg Trp Arg Arg Ser Arg Leu Asn Gly Leu Ala Ala Gln 
        675                 680                 685             

Arg Ala Arg Ala Ala Arg Asp Ser Leu Ser Leu Ser Ser Gly Ser Gly 
    690                 695                 700                 

Gly Gly Ser Ala Ser Ala Ser Asp Asp Asp Ala Asp Asp Ala Asp Gly 
705                 710                 715                 720 

Ala Leu Ala Ala Glu Ser Thr Pro Phe Leu Gly Leu Arg Gly Ala His 
                725                 730                 735     

Asp Ala Leu Arg Ser Asp Ser Pro Pro Leu Cys Pro Ala Ala Asp Ser 
            740                 745                 750         

Arg Thr Tyr Tyr Ser Leu Asp Ser His Ser Thr Arg Ala Ser Ser Arg 
        755                 760                 765             

His Ser Arg Gly Pro Pro Pro Arg Ala Lys Gln Asp Ser Ala Pro Leu 
    770                 775                 780                 

<210>   19
<211>   850
<212>   PRT
<213>   Homo sapiens

<400>   19
Met Arg Gln Val Cys Cys Ser Ala Leu Pro Pro Pro Pro Leu Glu Lys 
1               5                   10                  15      

Gly Arg Cys Ser Ser Tyr Ser Asp Ser Ser Ser Ser Ser Ser Glu Arg 
            20                  25                  30          

Ser Ser Ser Ser Ser Ser Ser Ser Ser Glu Ser Gly Ser Ser Ser Arg 
        35                  40                  45              

Ser Ser Ser Asn Asn Ser Ser Ile Ser Arg Pro Ala Ala Pro Pro Glu 
    50                  55                  60                  

Pro Arg Pro Gln Gln Gln Pro Gln Pro Arg Ser Pro Ala Ala Arg Arg 
65                  70                  75                  80  

Ala Ala Ala Arg Ser Arg Ala Ala Ala Ala Gly Gly Met Arg Arg Asp 
                85                  90                  95      

Pro Ala Pro Gly Phe Ser Met Leu Leu Phe Gly Val Ser Leu Ala Cys 
            100                 105                 110         

Tyr Ser Pro Ser Leu Lys Ser Val Gln Asp Gln Ala Tyr Lys Ala Pro 
        115                 120                 125             

Val Val Val Glu Gly Lys Val Gln Gly Leu Val Pro Ala Gly Gly Ser 
    130                 135                 140                 

Ser Ser Asn Ser Thr Arg Glu Pro Pro Ala Ser Gly Arg Val Ala Leu 
145                 150                 155                 160 

Val Lys Val Leu Asp Lys Trp Pro Leu Arg Ser Gly Gly Leu Gln Arg 
                165                 170                 175     

Glu Gln Val Ile Ser Val Gly Ser Cys Val Pro Leu Glu Arg Asn Gln 
            180                 185                 190         

Arg Tyr Ile Phe Phe Leu Glu Pro Thr Glu Gln Pro Leu Val Phe Lys 
        195                 200                 205             

Thr Ala Phe Ala Pro Leu Asp Thr Asn Gly Lys Asn Leu Lys Lys Glu 
    210                 215                 220                 

Val Gly Lys Ile Leu Cys Thr Asp Cys Ala Thr Arg Pro Lys Leu Lys 
225                 230                 235                 240 

Lys Met Lys Ser Gln Thr Gly Gln Val Gly Glu Lys Gln Ser Leu Lys 
                245                 250                 255     

Cys Glu Ala Ala Ala Gly Asn Pro Gln Pro Ser Tyr Arg Trp Phe Lys 
            260                 265                 270         

Asp Gly Lys Glu Leu Asn Arg Ser Arg Asp Ile Arg Ile Lys Tyr Gly 
        275                 280                 285             

Asn Gly Arg Lys Asn Ser Arg Leu Gln Phe Asn Lys Val Lys Val Glu 
    290                 295                 300                 

Asp Ala Gly Glu Tyr Val Cys Glu Ala Glu Asn Ile Leu Gly Lys Asp 
305                 310                 315                 320 

Thr Val Arg Gly Arg Leu Tyr Val Asn Ser Val Ser Thr Thr Leu Ser 
                325                 330                 335     

Ser Trp Ser Gly His Ala Arg Lys Cys Asn Glu Thr Ala Lys Ser Tyr 
            340                 345                 350         

Cys Val Asn Gly Gly Val Cys Tyr Tyr Ile Glu Gly Ile Asn Gln Leu 
        355                 360                 365             

Ser Cys Lys Cys Pro Asn Gly Phe Phe Gly Gln Arg Cys Leu Glu Lys 
    370                 375                 380                 

Leu Pro Leu Arg Leu Tyr Met Pro Asp Pro Lys Gln Lys Ala Glu Glu 
385                 390                 395                 400 

Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Val Ala Leu 
                405                 410                 415     

Leu Val Val Gly Ile Val Cys Val Val Ala Tyr Cys Lys Thr Lys Lys 
            420                 425                 430         

Gln Arg Lys Gln Met His Asn His Leu Arg Gln Asn Met Cys Pro Ala 
        435                 440                 445             

His Gln Asn Arg Ser Leu Ala Asn Gly Pro Ser His Pro Arg Leu Asp 
    450                 455                 460                 

Pro Glu Glu Ile Gln Met Ala Asp Tyr Ile Ser Lys Asn Val Pro Ala 
465                 470                 475                 480 

Thr Asp His Val Ile Arg Arg Glu Thr Glu Thr Thr Phe Ser Gly Ser 
                485                 490                 495     

His Ser Cys Ser Pro Ser His His Cys Ser Thr Ala Thr Pro Thr Ser 
            500                 505                 510         

Ser His Arg His Glu Ser His Thr Trp Ser Leu Glu Arg Ser Glu Ser 
        515                 520                 525             

Leu Thr Ser Asp Ser Gln Ser Gly Ile Met Leu Ser Ser Val Gly Thr 
    530                 535                 540                 

Ser Lys Cys Asn Ser Pro Ala Cys Val Glu Ala Arg Ala Arg Arg Ala 
545                 550                 555                 560 

Ala Ala Tyr Asn Leu Glu Glu Arg Arg Arg Ala Thr Ala Pro Pro Tyr 
                565                 570                 575     

His Asp Ser Val Asp Ser Leu Arg Asp Ser Pro His Ser Glu Arg Tyr 
            580                 585                 590         

Val Ser Ala Leu Thr Thr Pro Ala Arg Leu Ser Pro Val Asp Phe His 
        595                 600                 605             

Tyr Ser Leu Ala Thr Gln Val Pro Thr Phe Glu Ile Thr Ser Pro Asn 
    610                 615                 620                 

Ser Ala His Ala Val Ser Leu Pro Pro Ala Ala Pro Ile Ser Tyr Arg 
625                 630                 635                 640 

Leu Ala Glu Gln Gln Pro Leu Leu Arg His Pro Ala Pro Pro Gly Pro 
                645                 650                 655     

Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Ala Asp Met Gln Arg 
            660                 665                 670         

Ser Tyr Asp Ser Tyr Tyr Tyr Pro Ala Ala Gly Pro Gly Pro Arg Arg 
        675                 680                 685             

Gly Thr Cys Ala Leu Gly Gly Ser Leu Gly Ser Leu Pro Ala Ser Pro 
    690                 695                 700                 

Phe Arg Ile Pro Glu Asp Asp Glu Tyr Glu Thr Thr Gln Glu Cys Ala 
705                 710                 715                 720 

Pro Pro Pro Pro Pro Arg Pro Arg Ala Arg Gly Ala Ser Arg Arg Thr 
                725                 730                 735     

Ser Ala Gly Pro Arg Arg Trp Arg Arg Ser Arg Leu Asn Gly Leu Ala 
            740                 745                 750         

Ala Gln Arg Ala Arg Ala Ala Arg Asp Ser Leu Ser Leu Ser Ser Gly 
        755                 760                 765             

Ser Gly Gly Gly Ser Ala Ser Ala Ser Asp Asp Asp Ala Asp Asp Ala 
    770                 775                 780                 

Asp Gly Ala Leu Ala Ala Glu Ser Thr Pro Phe Leu Gly Leu Arg Gly 
785                 790                 795                 800 

Ala His Asp Ala Leu Arg Ser Asp Ser Pro Pro Leu Cys Pro Ala Ala 
                805                 810                 815     

Asp Ser Arg Thr Tyr Tyr Ser Leu Asp Ser His Ser Thr Arg Ala Ser 
            820                 825                 830         

Ser Arg His Ser Arg Gly Pro Pro Pro Arg Ala Lys Gln Asp Ser Ala 
        835                 840                 845             

Pro Leu 
    850 

<210>   20
<211>   844
<212>   PRT
<213>   Homo sapiens

<400>   20
Met Arg Gln Val Cys Cys Ser Ala Leu Pro Pro Pro Pro Leu Glu Lys 
1               5                   10                  15      

Gly Arg Cys Ser Ser Tyr Ser Asp Ser Ser Ser Ser Ser Ser Glu Arg 
            20                  25                  30          

Ser Ser Ser Ser Ser Ser Ser Ser Ser Glu Ser Gly Ser Ser Ser Arg 
        35                  40                  45              

Ser Ser Ser Asn Asn Ser Ser Ile Ser Arg Pro Ala Ala Pro Pro Glu 
    50                  55                  60                  

Pro Arg Pro Gln Gln Gln Pro Gln Pro Arg Ser Pro Ala Ala Arg Arg 
65                  70                  75                  80  

Ala Ala Ala Arg Ser Arg Ala Ala Ala Ala Gly Gly Met Arg Arg Asp 
                85                  90                  95      

Pro Ala Pro Gly Phe Ser Met Leu Leu Phe Gly Val Ser Leu Ala Cys 
            100                 105                 110         

Tyr Ser Pro Ser Leu Lys Ser Val Gln Asp Gln Ala Tyr Lys Ala Pro 
        115                 120                 125             

Val Val Val Glu Gly Lys Val Gln Gly Leu Val Pro Ala Gly Gly Ser 
    130                 135                 140                 

Ser Ser Asn Ser Thr Arg Glu Pro Pro Ala Ser Gly Arg Val Ala Leu 
145                 150                 155                 160 

Val Lys Val Leu Asp Lys Trp Pro Leu Arg Ser Gly Gly Leu Gln Arg 
                165                 170                 175     

Glu Gln Val Ile Ser Val Gly Ser Cys Val Pro Leu Glu Arg Asn Gln 
            180                 185                 190         

Arg Tyr Ile Phe Phe Leu Glu Pro Thr Glu Gln Pro Leu Val Phe Lys 
        195                 200                 205             

Thr Ala Phe Ala Pro Leu Asp Thr Asn Gly Lys Asn Leu Lys Lys Glu 
    210                 215                 220                 

Val Gly Lys Ile Leu Cys Thr Asp Cys Ala Thr Arg Pro Lys Leu Lys 
225                 230                 235                 240 

Lys Met Lys Ser Gln Thr Gly Gln Val Gly Glu Lys Gln Ser Leu Lys 
                245                 250                 255     

Cys Glu Ala Ala Ala Gly Asn Pro Gln Pro Ser Tyr Arg Trp Phe Lys 
            260                 265                 270         

Asp Gly Lys Glu Leu Asn Arg Ser Arg Asp Ile Arg Ile Lys Tyr Gly 
        275                 280                 285             

Asn Gly Arg Lys Asn Ser Arg Leu Gln Phe Asn Lys Val Lys Val Glu 
    290                 295                 300                 

Asp Ala Gly Glu Tyr Val Cys Glu Ala Glu Asn Ile Leu Gly Lys Asp 
305                 310                 315                 320 

Thr Val Arg Gly Arg Leu Tyr Val Asn Ser Val Ser Thr Thr Leu Ser 
                325                 330                 335     

Ser Trp Ser Gly His Ala Arg Lys Cys Asn Glu Thr Ala Lys Ser Tyr 
            340                 345                 350         

Cys Val Asn Gly Gly Val Cys Tyr Tyr Ile Glu Gly Ile Asn Gln Leu 
        355                 360                 365             

Ser Cys Lys Cys Pro Val Gly Tyr Thr Gly Asp Arg Cys Gln Gln Phe 
    370                 375                 380                 

Ala Met Val Asn Phe Ser Lys Ala Glu Glu Leu Tyr Gln Lys Arg Val 
385                 390                 395                 400 

Leu Thr Ile Thr Gly Ile Cys Val Ala Leu Leu Val Val Gly Ile Val 
                405                 410                 415     

Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Gln Met His 
            420                 425                 430         

Asn His Leu Arg Gln Asn Met Cys Pro Ala His Gln Asn Arg Ser Leu 
        435                 440                 445             

Ala Asn Gly Pro Ser His Pro Arg Leu Asp Pro Glu Glu Ile Gln Met 
    450                 455                 460                 

Ala Asp Tyr Ile Ser Lys Asn Val Pro Ala Thr Asp His Val Ile Arg 
465                 470                 475                 480 

Arg Glu Thr Glu Thr Thr Phe Ser Gly Ser His Ser Cys Ser Pro Ser 
                485                 490                 495     

His His Cys Ser Thr Ala Thr Pro Thr Ser Ser His Arg His Glu Ser 
            500                 505                 510         

His Thr Trp Ser Leu Glu Arg Ser Glu Ser Leu Thr Ser Asp Ser Gln 
        515                 520                 525             

Ser Gly Ile Met Leu Ser Ser Val Gly Thr Ser Lys Cys Asn Ser Pro 
    530                 535                 540                 

Ala Cys Val Glu Ala Arg Ala Arg Arg Ala Ala Ala Tyr Asn Leu Glu 
545                 550                 555                 560 

Glu Arg Arg Arg Ala Thr Ala Pro Pro Tyr His Asp Ser Val Asp Ser 
                565                 570                 575     

Leu Arg Asp Ser Pro His Ser Glu Arg Tyr Val Ser Ala Leu Thr Thr 
            580                 585                 590         

Pro Ala Arg Leu Ser Pro Val Asp Phe His Tyr Ser Leu Ala Thr Gln 
        595                 600                 605             

Val Pro Thr Phe Glu Ile Thr Ser Pro Asn Ser Ala His Ala Val Ser 
    610                 615                 620                 

Leu Pro Pro Ala Ala Pro Ile Ser Tyr Arg Leu Ala Glu Gln Gln Pro 
625                 630                 635                 640 

Leu Leu Arg His Pro Ala Pro Pro Gly Pro Gly Pro Gly Pro Gly Pro 
                645                 650                 655     

Gly Pro Gly Pro Gly Ala Asp Met Gln Arg Ser Tyr Asp Ser Tyr Tyr 
            660                 665                 670         

Tyr Pro Ala Ala Gly Pro Gly Pro Arg Arg Gly Thr Cys Ala Leu Gly 
        675                 680                 685             

Gly Ser Leu Gly Ser Leu Pro Ala Ser Pro Phe Arg Ile Pro Glu Asp 
    690                 695                 700                 

Asp Glu Tyr Glu Thr Thr Gln Glu Cys Ala Pro Pro Pro Pro Pro Arg 
705                 710                 715                 720 

Pro Arg Ala Arg Gly Ala Ser Arg Arg Thr Ser Ala Gly Pro Arg Arg 
                725                 730                 735     

Trp Arg Arg Ser Arg Leu Asn Gly Leu Ala Ala Gln Arg Ala Arg Ala 
            740                 745                 750         

Ala Arg Asp Ser Leu Ser Leu Ser Ser Gly Ser Gly Gly Gly Ser Ala 
        755                 760                 765             

Ser Ala Ser Asp Asp Asp Ala Asp Asp Ala Asp Gly Ala Leu Ala Ala 
    770                 775                 780                 

Glu Ser Thr Pro Phe Leu Gly Leu Arg Gly Ala His Asp Ala Leu Arg 
785                 790                 795                 800 

Ser Asp Ser Pro Pro Leu Cys Pro Ala Ala Asp Ser Arg Thr Tyr Tyr 
                805                 810                 815     

Ser Leu Asp Ser His Ser Thr Arg Ala Ser Ser Arg His Ser Arg Gly 
            820                 825                 830         

Pro Pro Pro Arg Ala Lys Gln Asp Ser Ala Pro Leu 
        835                 840                 

<210>   21
<211>   858
<212>   PRT
<213>   Homo sapiens

<400>   21
Met Arg Gln Val Cys Cys Ser Ala Leu Pro Pro Pro Pro Leu Glu Lys 
1               5                   10                  15      

Gly Arg Cys Ser Ser Tyr Ser Asp Ser Ser Ser Ser Ser Ser Glu Arg 
            20                  25                  30          

Ser Ser Ser Ser Ser Ser Ser Ser Ser Glu Ser Gly Ser Ser Ser Arg 
        35                  40                  45              

Ser Ser Ser Asn Asn Ser Ser Ile Ser Arg Pro Ala Ala Pro Pro Glu 
    50                  55                  60                  

Pro Arg Pro Gln Gln Gln Pro Gln Pro Arg Ser Pro Ala Ala Arg Arg 
65                  70                  75                  80  

Ala Ala Ala Arg Ser Arg Ala Ala Ala Ala Gly Gly Met Arg Arg Asp 
                85                  90                  95      

Pro Ala Pro Gly Phe Ser Met Leu Leu Phe Gly Val Ser Leu Ala Cys 
            100                 105                 110         

Tyr Ser Pro Ser Leu Lys Ser Val Gln Asp Gln Ala Tyr Lys Ala Pro 
        115                 120                 125             

Val Val Val Glu Gly Lys Val Gln Gly Leu Val Pro Ala Gly Gly Ser 
    130                 135                 140                 

Ser Ser Asn Ser Thr Arg Glu Pro Pro Ala Ser Gly Arg Val Ala Leu 
145                 150                 155                 160 

Val Lys Val Leu Asp Lys Trp Pro Leu Arg Ser Gly Gly Leu Gln Arg 
                165                 170                 175     

Glu Gln Val Ile Ser Val Gly Ser Cys Val Pro Leu Glu Arg Asn Gln 
            180                 185                 190         

Arg Tyr Ile Phe Phe Leu Glu Pro Thr Glu Gln Pro Leu Val Phe Lys 
        195                 200                 205             

Thr Ala Phe Ala Pro Leu Asp Thr Asn Gly Lys Asn Leu Lys Lys Glu 
    210                 215                 220                 

Val Gly Lys Ile Leu Cys Thr Asp Cys Ala Thr Arg Pro Lys Leu Lys 
225                 230                 235                 240 

Lys Met Lys Ser Gln Thr Gly Gln Val Gly Glu Lys Gln Ser Leu Lys 
                245                 250                 255     

Cys Glu Ala Ala Ala Gly Asn Pro Gln Pro Ser Tyr Arg Trp Phe Lys 
            260                 265                 270         

Asp Gly Lys Glu Leu Asn Arg Ser Arg Asp Ile Arg Ile Lys Tyr Gly 
        275                 280                 285             

Asn Gly Arg Lys Asn Ser Arg Leu Gln Phe Asn Lys Val Lys Val Glu 
    290                 295                 300                 

Asp Ala Gly Glu Tyr Val Cys Glu Ala Glu Asn Ile Leu Gly Lys Asp 
305                 310                 315                 320 

Thr Val Arg Gly Arg Leu Tyr Val Asn Ser Val Ser Thr Thr Leu Ser 
                325                 330                 335     

Ser Trp Ser Gly His Ala Arg Lys Cys Asn Glu Thr Ala Lys Ser Tyr 
            340                 345                 350         

Cys Val Asn Gly Gly Val Cys Tyr Tyr Ile Glu Gly Ile Asn Gln Leu 
        355                 360                 365             

Ser Cys Lys Cys Pro Asn Gly Phe Phe Gly Gln Arg Cys Leu Glu Lys 
    370                 375                 380                 

Leu Pro Leu Arg Leu Tyr Met Pro Asp Pro Lys Gln Lys His Leu Gly 
385                 390                 395                 400 

Phe Glu Leu Lys Glu Ala Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr 
                405                 410                 415     

Ile Thr Gly Ile Cys Val Ala Leu Leu Val Val Gly Ile Val Cys Val 
            420                 425                 430         

Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Gln Met His Asn His 
        435                 440                 445             

Leu Arg Gln Asn Met Cys Pro Ala His Gln Asn Arg Ser Leu Ala Asn 
    450                 455                 460                 

Gly Pro Ser His Pro Arg Leu Asp Pro Glu Glu Ile Gln Met Ala Asp 
465                 470                 475                 480 

Tyr Ile Ser Lys Asn Val Pro Ala Thr Asp His Val Ile Arg Arg Glu 
                485                 490                 495     

Thr Glu Thr Thr Phe Ser Gly Ser His Ser Cys Ser Pro Ser His His 
            500                 505                 510         

Cys Ser Thr Ala Thr Pro Thr Ser Ser His Arg His Glu Ser His Thr 
        515                 520                 525             

Trp Ser Leu Glu Arg Ser Glu Ser Leu Thr Ser Asp Ser Gln Ser Gly 
    530                 535                 540                 

Ile Met Leu Ser Ser Val Gly Thr Ser Lys Cys Asn Ser Pro Ala Cys 
545                 550                 555                 560 

Val Glu Ala Arg Ala Arg Arg Ala Ala Ala Tyr Asn Leu Glu Glu Arg 
                565                 570                 575     

Arg Arg Ala Thr Ala Pro Pro Tyr His Asp Ser Val Asp Ser Leu Arg 
            580                 585                 590         

Asp Ser Pro His Ser Glu Arg Tyr Val Ser Ala Leu Thr Thr Pro Ala 
        595                 600                 605             

Arg Leu Ser Pro Val Asp Phe His Tyr Ser Leu Ala Thr Gln Val Pro 
    610                 615                 620                 

Thr Phe Glu Ile Thr Ser Pro Asn Ser Ala His Ala Val Ser Leu Pro 
625                 630                 635                 640 

Pro Ala Ala Pro Ile Ser Tyr Arg Leu Ala Glu Gln Gln Pro Leu Leu 
                645                 650                 655     

Arg His Pro Ala Pro Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro 
            660                 665                 670         

Gly Pro Gly Ala Asp Met Gln Arg Ser Tyr Asp Ser Tyr Tyr Tyr Pro 
        675                 680                 685             

Ala Ala Gly Pro Gly Pro Arg Arg Gly Thr Cys Ala Leu Gly Gly Ser 
    690                 695                 700                 

Leu Gly Ser Leu Pro Ala Ser Pro Phe Arg Ile Pro Glu Asp Asp Glu 
705                 710                 715                 720 

Tyr Glu Thr Thr Gln Glu Cys Ala Pro Pro Pro Pro Pro Arg Pro Arg 
                725                 730                 735     

Ala Arg Gly Ala Ser Arg Arg Thr Ser Ala Gly Pro Arg Arg Trp Arg 
            740                 745                 750         

Arg Ser Arg Leu Asn Gly Leu Ala Ala Gln Arg Ala Arg Ala Ala Arg 
        755                 760                 765             

Asp Ser Leu Ser Leu Ser Ser Gly Ser Gly Gly Gly Ser Ala Ser Ala 
    770                 775                 780                 

Ser Asp Asp Asp Ala Asp Asp Ala Asp Gly Ala Leu Ala Ala Glu Ser 
785                 790                 795                 800 

Thr Pro Phe Leu Gly Leu Arg Gly Ala His Asp Ala Leu Arg Ser Asp 
                805                 810                 815     

Ser Pro Pro Leu Cys Pro Ala Ala Asp Ser Arg Thr Tyr Tyr Ser Leu 
            820                 825                 830         

Asp Ser His Ser Thr Arg Ala Ser Ser Arg His Ser Arg Gly Pro Pro 
        835                 840                 845             

Pro Arg Ala Lys Gln Asp Ser Ala Pro Leu 
    850                 855             

<210>   22
<211>   852
<212>   PRT
<213>   Homo sapiens

<400>   22
Met Arg Gln Val Cys Cys Ser Ala Leu Pro Pro Pro Pro Leu Glu Lys 
1               5                   10                  15      

Gly Arg Cys Ser Ser Tyr Ser Asp Ser Ser Ser Ser Ser Ser Glu Arg 
            20                  25                  30          

Ser Ser Ser Ser Ser Ser Ser Ser Ser Glu Ser Gly Ser Ser Ser Arg 
        35                  40                  45              

Ser Ser Ser Asn Asn Ser Ser Ile Ser Arg Pro Ala Ala Pro Pro Glu 
    50                  55                  60                  

Pro Arg Pro Gln Gln Gln Pro Gln Pro Arg Ser Pro Ala Ala Arg Arg 
65                  70                  75                  80  

Ala Ala Ala Arg Ser Arg Ala Ala Ala Ala Gly Gly Met Arg Arg Asp 
                85                  90                  95      

Pro Ala Pro Gly Phe Ser Met Leu Leu Phe Gly Val Ser Leu Ala Cys 
            100                 105                 110         

Tyr Ser Pro Ser Leu Lys Ser Val Gln Asp Gln Ala Tyr Lys Ala Pro 
        115                 120                 125             

Val Val Val Glu Gly Lys Val Gln Gly Leu Val Pro Ala Gly Gly Ser 
    130                 135                 140                 

Ser Ser Asn Ser Thr Arg Glu Pro Pro Ala Ser Gly Arg Val Ala Leu 
145                 150                 155                 160 

Val Lys Val Leu Asp Lys Trp Pro Leu Arg Ser Gly Gly Leu Gln Arg 
                165                 170                 175     

Glu Gln Val Ile Ser Val Gly Ser Cys Val Pro Leu Glu Arg Asn Gln 
            180                 185                 190         

Arg Tyr Ile Phe Phe Leu Glu Pro Thr Glu Gln Pro Leu Val Phe Lys 
        195                 200                 205             

Thr Ala Phe Ala Pro Leu Asp Thr Asn Gly Lys Asn Leu Lys Lys Glu 
    210                 215                 220                 

Val Gly Lys Ile Leu Cys Thr Asp Cys Ala Thr Arg Pro Lys Leu Lys 
225                 230                 235                 240 

Lys Met Lys Ser Gln Thr Gly Gln Val Gly Glu Lys Gln Ser Leu Lys 
                245                 250                 255     

Cys Glu Ala Ala Ala Gly Asn Pro Gln Pro Ser Tyr Arg Trp Phe Lys 
            260                 265                 270         

Asp Gly Lys Glu Leu Asn Arg Ser Arg Asp Ile Arg Ile Lys Tyr Gly 
        275                 280                 285             

Asn Gly Arg Lys Asn Ser Arg Leu Gln Phe Asn Lys Val Lys Val Glu 
    290                 295                 300                 

Asp Ala Gly Glu Tyr Val Cys Glu Ala Glu Asn Ile Leu Gly Lys Asp 
305                 310                 315                 320 

Thr Val Arg Gly Arg Leu Tyr Val Asn Ser Val Ser Thr Thr Leu Ser 
                325                 330                 335     

Ser Trp Ser Gly His Ala Arg Lys Cys Asn Glu Thr Ala Lys Ser Tyr 
            340                 345                 350         

Cys Val Asn Gly Gly Val Cys Tyr Tyr Ile Glu Gly Ile Asn Gln Leu 
        355                 360                 365             

Ser Cys Lys Cys Pro Val Gly Tyr Thr Gly Asp Arg Cys Gln Gln Phe 
    370                 375                 380                 

Ala Met Val Asn Phe Ser Lys His Leu Gly Phe Glu Leu Lys Glu Ala 
385                 390                 395                 400 

Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Val 
                405                 410                 415     

Ala Leu Leu Val Val Gly Ile Val Cys Val Val Ala Tyr Cys Lys Thr 
            420                 425                 430         

Lys Lys Gln Arg Lys Gln Met His Asn His Leu Arg Gln Asn Met Cys 
        435                 440                 445             

Pro Ala His Gln Asn Arg Ser Leu Ala Asn Gly Pro Ser His Pro Arg 
    450                 455                 460                 

Leu Asp Pro Glu Glu Ile Gln Met Ala Asp Tyr Ile Ser Lys Asn Val 
465                 470                 475                 480 

Pro Ala Thr Asp His Val Ile Arg Arg Glu Thr Glu Thr Thr Phe Ser 
                485                 490                 495     

Gly Ser His Ser Cys Ser Pro Ser His His Cys Ser Thr Ala Thr Pro 
            500                 505                 510         

Thr Ser Ser His Arg His Glu Ser His Thr Trp Ser Leu Glu Arg Ser 
        515                 520                 525             

Glu Ser Leu Thr Ser Asp Ser Gln Ser Gly Ile Met Leu Ser Ser Val 
    530                 535                 540                 

Gly Thr Ser Lys Cys Asn Ser Pro Ala Cys Val Glu Ala Arg Ala Arg 
545                 550                 555                 560 

Arg Ala Ala Ala Tyr Asn Leu Glu Glu Arg Arg Arg Ala Thr Ala Pro 
                565                 570                 575     

Pro Tyr His Asp Ser Val Asp Ser Leu Arg Asp Ser Pro His Ser Glu 
            580                 585                 590         

Arg Tyr Val Ser Ala Leu Thr Thr Pro Ala Arg Leu Ser Pro Val Asp 
        595                 600                 605             

Phe His Tyr Ser Leu Ala Thr Gln Val Pro Thr Phe Glu Ile Thr Ser 
    610                 615                 620                 

Pro Asn Ser Ala His Ala Val Ser Leu Pro Pro Ala Ala Pro Ile Ser 
625                 630                 635                 640 

Tyr Arg Leu Ala Glu Gln Gln Pro Leu Leu Arg His Pro Ala Pro Pro 
                645                 650                 655     

Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Ala Asp Met 
            660                 665                 670         

Gln Arg Ser Tyr Asp Ser Tyr Tyr Tyr Pro Ala Ala Gly Pro Gly Pro 
        675                 680                 685             

Arg Arg Gly Thr Cys Ala Leu Gly Gly Ser Leu Gly Ser Leu Pro Ala 
    690                 695                 700                 

Ser Pro Phe Arg Ile Pro Glu Asp Asp Glu Tyr Glu Thr Thr Gln Glu 
705                 710                 715                 720 

Cys Ala Pro Pro Pro Pro Pro Arg Pro Arg Ala Arg Gly Ala Ser Arg 
                725                 730                 735     

Arg Thr Ser Ala Gly Pro Arg Arg Trp Arg Arg Ser Arg Leu Asn Gly 
            740                 745                 750         

Leu Ala Ala Gln Arg Ala Arg Ala Ala Arg Asp Ser Leu Ser Leu Ser 
        755                 760                 765             

Ser Gly Ser Gly Gly Gly Ser Ala Ser Ala Ser Asp Asp Asp Ala Asp 
    770                 775                 780                 

Asp Ala Asp Gly Ala Leu Ala Ala Glu Ser Thr Pro Phe Leu Gly Leu 
785                 790                 795                 800 

Arg Gly Ala His Asp Ala Leu Arg Ser Asp Ser Pro Pro Leu Cys Pro 
                805                 810                 815     

Ala Ala Asp Ser Arg Thr Tyr Tyr Ser Leu Asp Ser His Ser Thr Arg 
            820                 825                 830         

Ala Ser Ser Arg His Ser Arg Gly Pro Pro Pro Arg Ala Lys Gln Asp 
        835                 840                 845             

Ser Ala Pro Leu 
    850         

<210>   23
<211>   696
<212>   PRT
<213>   Homo sapiens

<400>   23
Met Ser Glu Gly Ala Ala Ala Ala Ser Pro Pro Gly Ala Ala Ser Ala 
1               5                   10                  15      

Ala Ala Ala Ser Ala Glu Glu Gly Thr Ala Ala Ala Ala Ala Ala Ala 
            20                  25                  30          

Ala Ala Gly Gly Gly Pro Asp Gly Gly Gly Glu Gly Ala Ala Glu Pro 
        35                  40                  45              

Pro Arg Glu Leu Arg Cys Ser Asp Cys Ile Val Trp Asn Arg Gln Gln 
    50                  55                  60                  

Thr Trp Leu Cys Val Val Pro Leu Phe Ile Gly Phe Ile Gly Leu Gly 
65                  70                  75                  80  

Leu Ser Leu Met Leu Leu Lys Trp Ile Val Val Gly Ser Val Lys Glu 
                85                  90                  95      

Tyr Val Pro Thr Asp Leu Val Asp Ser Lys Gly Met Gly Gln Asp Pro 
            100                 105                 110         

Phe Phe Leu Ser Lys Pro Ser Ser Phe Pro Lys Ala Met Glu Thr Thr 
        115                 120                 125             

Thr Thr Thr Thr Ser Thr Thr Ser Pro Ala Thr Pro Ser Ala Gly Gly 
    130                 135                 140                 

Ala Ala Ser Ser Arg Thr Pro Asn Arg Ile Ser Thr Arg Leu Thr Thr 
145                 150                 155                 160 

Ile Thr Arg Ala Pro Thr Arg Phe Pro Gly His Arg Val Pro Ile Arg 
                165                 170                 175     

Ala Ser Pro Arg Ser Thr Thr Ala Arg Asn Thr Ala Ala Pro Ala Thr 
            180                 185                 190         

Val Pro Ser Thr Thr Ala Pro Phe Phe Ser Ser Ser Thr Leu Gly Ser 
        195                 200                 205             

Arg Pro Pro Val Pro Gly Thr Pro Ser Thr Gln Ala Met Pro Ser Trp 
    210                 215                 220                 

Pro Thr Ala Ala Tyr Ala Thr Ser Ser Tyr Leu His Asp Ser Thr Pro 
225                 230                 235                 240 

Ser Trp Thr Leu Ser Pro Phe Gln Asp Ala Ala Ser Ser Ser Ser Ser 
                245                 250                 255     

Ser Ser Ser Ser Ala Thr Thr Thr Thr Pro Glu Thr Ser Thr Ser Pro 
            260                 265                 270         

Lys Phe His Thr Thr Thr Tyr Ser Thr Glu Arg Ser Glu His Phe Lys 
        275                 280                 285             

Pro Cys Arg Asp Lys Asp Leu Ala Tyr Cys Leu Asn Asp Gly Glu Cys 
    290                 295                 300                 

Phe Val Ile Glu Thr Leu Thr Gly Ser His Lys His Cys Arg Cys Lys 
305                 310                 315                 320 

Glu Gly Tyr Gln Gly Val Arg Cys Asp Gln Phe Leu Pro Lys Thr Asp 
                325                 330                 335     

Ser Ile Leu Ser Asp Pro Thr Asp His Leu Gly Ile Glu Phe Met Glu 
            340                 345                 350         

Ser Glu Glu Val Tyr Gln Arg Gln Val Leu Ser Ile Ser Cys Ile Ile 
        355                 360                 365             

Phe Gly Ile Val Ile Val Gly Met Phe Cys Ala Ala Phe Tyr Phe Lys 
    370                 375                 380                 

Ser Lys Lys Gln Ala Lys Gln Ile Gln Glu Gln Leu Lys Val Pro Gln 
385                 390                 395                 400 

Asn Gly Lys Ser Tyr Ser Leu Lys Ala Ser Ser Thr Met Ala Lys Ser 
                405                 410                 415     

Glu Asn Leu Val Lys Ser His Val Gln Leu Gln Asn Tyr Ser Lys Val 
            420                 425                 430         

Glu Arg His Pro Val Thr Ala Leu Glu Lys Met Met Glu Ser Ser Phe 
        435                 440                 445             

Val Gly Pro Gln Ser Phe Pro Glu Val Pro Ser Pro Asp Arg Gly Ser 
    450                 455                 460                 

Gln Ser Val Lys His His Arg Ser Leu Ser Ser Cys Cys Ser Pro Gly 
465                 470                 475                 480 

Gln Arg Ser Gly Met Leu His Arg Asn Ala Phe Arg Arg Thr Pro Pro 
                485                 490                 495     

Ser Pro Arg Ser Arg Leu Gly Gly Ile Val Gly Pro Ala Tyr Gln Gln 
            500                 505                 510         

Leu Glu Glu Ser Arg Ile Pro Asp Gln Asp Thr Ile Pro Cys Gln Gly 
        515                 520                 525             

Tyr Ser Ser Ser Gly Leu Lys Thr Gln Arg Asn Thr Ser Ile Asn Met 
    530                 535                 540                 

Gln Leu Pro Ser Arg Glu Thr Asn Pro Tyr Phe Asn Ser Leu Glu Gln 
545                 550                 555                 560 

Lys Asp Leu Val Gly Tyr Ser Ser Thr Arg Ala Ser Ser Val Pro Ile 
                565                 570                 575     

Ile Pro Ser Val Gly Leu Glu Glu Thr Cys Leu Gln Met Pro Gly Ile 
            580                 585                 590         

Ser Glu Val Lys Ser Ile Lys Trp Cys Lys Asn Ser Tyr Ser Ala Asp 
        595                 600                 605             

Val Val Asn Val Ser Ile Pro Val Ser Asp Cys Leu Ile Ala Glu Gln 
    610                 615                 620                 

Gln Glu Val Lys Ile Leu Leu Glu Thr Val Gln Glu Gln Ile Arg Ile 
625                 630                 635                 640 

Leu Thr Asp Ala Arg Arg Ser Glu Asp Tyr Glu Leu Ala Ser Val Glu 
                645                 650                 655     

Thr Glu Asp Ser Ala Ser Glu Asn Thr Ala Phe Leu Pro Leu Ser Pro 
            660                 665                 670         

Thr Ala Lys Ser Glu Arg Glu Ala Gln Phe Val Leu Arg Asn Glu Ile 
        675                 680                 685             

Gln Arg Asp Ser Ala Leu Thr Lys 
    690                 695     

<210>   24
<211>   695
<212>   PRT
<213>   Homo sapiens

<400>   24
Met Ser Glu Gly Ala Ala Ala Ala Ser Pro Pro Gly Ala Ala Ser Ala 
1               5                   10                  15      

Ala Ala Ala Ser Ala Glu Glu Gly Thr Ala Ala Ala Ala Ala Ala Ala 
            20                  25                  30          

Ala Ala Gly Gly Gly Pro Asp Gly Gly Gly Glu Gly Ala Ala Glu Pro 
        35                  40                  45              

Pro Arg Glu Leu Arg Cys Ser Asp Cys Ile Val Trp Asn Arg Gln Gln 
    50                  55                  60                  

Thr Trp Leu Cys Val Val Pro Leu Phe Ile Gly Phe Ile Gly Leu Gly 
65                  70                  75                  80  

Leu Ser Leu Met Leu Leu Lys Trp Ile Val Val Gly Ser Val Lys Glu 
                85                  90                  95      

Tyr Val Pro Thr Asp Leu Val Asp Ser Lys Gly Met Gly Gln Asp Pro 
            100                 105                 110         

Phe Phe Leu Ser Lys Pro Ser Ser Phe Pro Lys Ala Met Glu Thr Thr 
        115                 120                 125             

Thr Thr Thr Thr Ser Thr Thr Ser Pro Ala Thr Pro Ser Ala Gly Gly 
    130                 135                 140                 

Ala Ala Ser Ser Arg Thr Pro Asn Arg Ile Ser Thr Arg Leu Thr Thr 
145                 150                 155                 160 

Ile Thr Arg Ala Pro Thr Arg Phe Pro Gly His Arg Val Pro Ile Arg 
                165                 170                 175     

Ala Ser Pro Arg Ser Thr Thr Ala Arg Asn Thr Ala Ala Pro Ala Thr 
            180                 185                 190         

Val Pro Ser Thr Thr Ala Pro Phe Phe Ser Ser Ser Thr Leu Gly Ser 
        195                 200                 205             

Arg Pro Pro Val Pro Gly Thr Pro Ser Thr Gln Ala Met Pro Ser Trp 
    210                 215                 220                 

Pro Thr Ala Ala Tyr Ala Thr Ser Ser Tyr Leu His Asp Ser Thr Pro 
225                 230                 235                 240 

Ser Trp Thr Leu Ser Pro Phe Gln Asp Ala Ala Ser Ser Ser Ser Ser 
                245                 250                 255     

Ser Ser Ser Ser Ala Thr Thr Thr Thr Pro Glu Thr Ser Thr Ser Pro 
            260                 265                 270         

Lys Phe His Thr Thr Thr Tyr Ser Thr Glu Arg Ser Glu His Phe Lys 
        275                 280                 285             

Pro Cys Arg Asp Lys Asp Leu Ala Tyr Cys Leu Asn Asp Gly Glu Cys 
    290                 295                 300                 

Phe Val Ile Glu Thr Leu Thr Gly Ser His Lys His Cys Arg Cys Lys 
305                 310                 315                 320 

Glu Gly Tyr Gln Gly Val Arg Cys Asp Gln Phe Leu Pro Lys Thr Asp 
                325                 330                 335     

Ser Ile Leu Ser Asp Pro Asn His Leu Gly Ile Glu Phe Met Glu Ser 
            340                 345                 350         

Glu Glu Val Tyr Gln Arg Gln Val Leu Ser Ile Ser Cys Ile Ile Phe 
        355                 360                 365             

Gly Ile Val Ile Val Gly Met Phe Cys Ala Ala Phe Tyr Phe Lys Ser 
    370                 375                 380                 

Lys Lys Gln Ala Lys Gln Ile Gln Glu Gln Leu Lys Val Pro Gln Asn 
385                 390                 395                 400 

Gly Lys Ser Tyr Ser Leu Lys Ala Ser Ser Thr Met Ala Lys Ser Glu 
                405                 410                 415     

Asn Leu Val Lys Ser His Val Gln Leu Gln Asn Tyr Ser Lys Val Glu 
            420                 425                 430         

Arg His Pro Val Thr Ala Leu Glu Lys Met Met Glu Ser Ser Phe Val 
        435                 440                 445             

Gly Pro Gln Ser Phe Pro Glu Val Pro Ser Pro Asp Arg Gly Ser Gln 
    450                 455                 460                 

Ser Val Lys His His Arg Ser Leu Ser Ser Cys Cys Ser Pro Gly Gln 
465                 470                 475                 480 

Arg Ser Gly Met Leu His Arg Asn Ala Phe Arg Arg Thr Pro Pro Ser 
                485                 490                 495     

Pro Arg Ser Arg Leu Gly Gly Ile Val Gly Pro Ala Tyr Gln Gln Leu 
            500                 505                 510         

Glu Glu Ser Arg Ile Pro Asp Gln Asp Thr Ile Pro Cys Gln Gly Tyr 
        515                 520                 525             

Ser Ser Ser Gly Leu Lys Thr Gln Arg Asn Thr Ser Ile Asn Met Gln 
    530                 535                 540                 

Leu Pro Ser Arg Glu Thr Asn Pro Tyr Phe Asn Ser Leu Glu Gln Lys 
545                 550                 555                 560 

Asp Leu Val Gly Tyr Ser Ser Thr Arg Ala Ser Ser Val Pro Ile Ile 
                565                 570                 575     

Pro Ser Val Gly Leu Glu Glu Thr Cys Leu Gln Met Pro Gly Ile Ser 
            580                 585                 590         

Glu Val Lys Ser Ile Lys Trp Cys Lys Asn Ser Tyr Ser Ala Asp Val 
        595                 600                 605             

Val Asn Val Ser Ile Pro Val Ser Asp Cys Leu Ile Ala Glu Gln Gln 
    610                 615                 620                 

Glu Val Lys Ile Leu Leu Glu Thr Val Gln Glu Gln Ile Arg Ile Leu 
625                 630                 635                 640 

Thr Asp Ala Arg Arg Ser Glu Asp Tyr Glu Leu Ala Ser Val Glu Thr 
                645                 650                 655     

Glu Asp Ser Ala Ser Glu Asn Thr Ala Phe Leu Pro Leu Ser Pro Thr 
            660                 665                 670         

Ala Lys Ser Glu Arg Glu Ala Gln Phe Val Leu Arg Asn Glu Ile Gln 
        675                 680                 685             

Arg Asp Ser Ala Leu Thr Lys 
    690                 695 

<210>   25
<211>   499
<212>   PRT
<213>   Homo sapiens

<400>   25
Met Glu Cys Gly Ile Pro Pro Thr Leu Val Cys Val Gly Arg Gly Gly 
1               5                   10                  15      

Gly Leu His Thr Ile Asn Ile Ile Ile Trp Tyr Tyr Phe Pro Ser Ala 
            20                  25                  30          

Trp Arg Thr Cys Phe Asn Ile Ser Ser Ser Val Gly Leu Leu Leu Thr 
        35                  40                  45              

Asn Ser Tyr Lys Phe Tyr Thr Thr Thr Tyr Ser Thr Glu Arg Ser Glu 
    50                  55                  60                  

His Phe Lys Pro Cys Arg Asp Lys Asp Leu Ala Tyr Cys Leu Asn Asp 
65                  70                  75                  80  

Gly Glu Cys Phe Val Ile Glu Thr Leu Thr Gly Ser His Lys His Cys 
                85                  90                  95      

Arg Cys Lys Glu Gly Tyr Gln Gly Val Arg Cys Asp Gln Phe Leu Pro 
            100                 105                 110         

Lys Thr Asp Ser Ile Leu Ser Asp Pro Thr Asp His Leu Gly Ile Glu 
        115                 120                 125             

Phe Met Glu Ser Glu Glu Val Tyr Gln Arg Gln Val Leu Ser Ile Ser 
    130                 135                 140                 

Cys Ile Ile Phe Gly Ile Val Ile Val Gly Met Phe Cys Ala Ala Phe 
145                 150                 155                 160 

Tyr Phe Lys Ser Lys Lys Gln Ala Lys Gln Ile Gln Glu Gln Leu Lys 
                165                 170                 175     

Val Pro Gln Asn Gly Lys Ser Tyr Ser Leu Lys Ala Ser Ser Thr Met 
            180                 185                 190         

Ala Lys Ser Glu Asn Leu Val Lys Ser His Val Gln Leu Gln Asn Tyr 
        195                 200                 205             

Ser Lys Val Glu Arg His Pro Val Thr Ala Leu Glu Lys Met Met Glu 
    210                 215                 220                 

Ser Ser Phe Val Gly Pro Gln Ser Phe Pro Glu Val Pro Ser Pro Asp 
225                 230                 235                 240 

Arg Gly Ser Gln Ser Val Lys His His Arg Ser Leu Ser Ser Cys Cys 
                245                 250                 255     

Ser Pro Gly Gln Arg Ser Gly Met Leu His Arg Asn Ala Phe Arg Arg 
            260                 265                 270         

Thr Pro Pro Ser Pro Arg Ser Arg Leu Gly Gly Ile Val Gly Pro Ala 
        275                 280                 285             

Tyr Gln Gln Leu Glu Glu Ser Arg Ile Pro Asp Gln Asp Thr Ile Pro 
    290                 295                 300                 

Cys Gln Gly Ile Glu Val Arg Lys Thr Ile Ser His Leu Pro Ile Gln 
305                 310                 315                 320 

Leu Trp Cys Val Glu Arg Pro Leu Asp Leu Lys Tyr Ser Ser Ser Gly 
                325                 330                 335     

Leu Lys Thr Gln Arg Asn Thr Ser Ile Asn Met Gln Leu Pro Ser Arg 
            340                 345                 350         

Glu Thr Asn Pro Tyr Phe Asn Ser Leu Glu Gln Lys Asp Leu Val Gly 
        355                 360                 365             

Tyr Ser Ser Thr Arg Ala Ser Ser Val Pro Ile Ile Pro Ser Val Gly 
    370                 375                 380                 

Leu Glu Glu Thr Cys Leu Gln Met Pro Gly Ile Ser Glu Val Lys Ser 
385                 390                 395                 400 

Ile Lys Trp Cys Lys Asn Ser Tyr Ser Ala Asp Val Val Asn Val Ser 
                405                 410                 415     

Ile Pro Val Ser Asp Cys Leu Ile Ala Glu Gln Gln Glu Val Lys Ile 
            420                 425                 430         

Leu Leu Glu Thr Val Gln Glu Gln Ile Arg Ile Leu Thr Asp Ala Arg 
        435                 440                 445             

Arg Ser Glu Asp Tyr Glu Leu Ala Ser Val Glu Thr Glu Asp Ser Ala 
    450                 455                 460                 

Ser Glu Asn Thr Ala Phe Leu Pro Leu Ser Pro Thr Ala Lys Ser Glu 
465                 470                 475                 480 

Arg Glu Ala Gln Phe Val Leu Arg Asn Glu Ile Gln Arg Asp Ser Ala 
                485                 490                 495     

Leu Thr Lys 
            

<210>   26
<211>   115
<212>   PRT
<213>   Homo sapiens

<400>   26
Met Pro Thr Asp His Glu Glu Pro Cys Gly Pro Ser His Lys Ser Phe 
1               5                   10                  15      

Cys Leu Asn Gly Gly Leu Cys Tyr Val Ile Pro Thr Ile Pro Ser Pro 
            20                  25                  30          

Phe Cys Arg Cys Val Glu Asn Tyr Thr Gly Ala Arg Cys Glu Glu Val 
        35                  40                  45              

Phe Leu Pro Gly Ser Ser Ile Gln Thr Lys Ser Asn Leu Phe Glu Ala 
    50                  55                  60                  

Phe Val Ala Leu Ala Val Leu Val Thr Leu Ile Ile Gly Ala Phe Tyr 
65                  70                  75                  80  

Phe Leu Cys Arg Lys Gly His Phe Gln Arg Ala Ser Ser Val Gln Tyr 
                85                  90                  95      

Asp Ile Asn Leu Val Glu Thr Ser Ser Thr Ser Ala His His Ser His 
            100                 105                 110         

Glu Gln His 
        115 

<210>   27
<211>   65
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Recombinant human neuregulin 1beta

<400>   27
Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
1               5                   10                  15      

Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          

Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
        35                  40                  45              

Val Met Ala Ser Phe Tyr Lys His Leu Gly Ile Glu Phe Met Glu Ala 
    50                  55                  60                  

Glu 
65  

<210>   28
<211>   210
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Furin domain fragment 1

<400>   28
Met Arg Leu Gly Leu Cys Val Val Ala Leu Val Leu Ser Trp Thr His 
1               5                   10                  15      

Leu Thr Ile Ser Ser Arg Gly Ile Lys Gly Lys Arg Gln Arg Arg Ile 
            20                  25                  30          

Ser Ala Glu Gly Ser Gln Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser 
        35                  40                  45              

Glu Val Asn Gly Cys Leu Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu 
    50                  55                  60                  

Glu Arg Asn Asp Ile Arg Gln Val Gly Val Cys Leu Pro Ser Cys Pro 
65                  70                  75                  80  

Pro Gly Tyr Phe Asp Ala Arg Asn Pro Asp Met Asn Lys Cys Ile Lys 
                85                  90                  95      

Cys Lys Ile Glu His Cys Glu Ala Cys Phe Ser His Asn Phe Cys Thr 
            100                 105                 110         

Lys Cys Lys Glu Gly Leu Tyr Leu His Lys Gly Arg Cys Tyr Pro Ala 
        115                 120                 125             

Cys Pro Glu Gly Ser Ser Ala Ala Asn Gly Thr Met Glu Cys Ser Ser 
    130                 135                 140                 

Pro Ala Gln Cys Glu Met Ser Glu Trp Ser Pro Trp Gly Pro Cys Ser 
145                 150                 155                 160 

Lys Lys Gln Gln Leu Cys Gly Phe Arg Arg Gly Ser Glu Glu Arg Thr 
                165                 170                 175     

Arg Arg Val Leu His Ala Pro Val Gly Asp His Ala Ala Cys Ser Asp 
            180                 185                 190         

Thr Lys Glu Thr Arg Arg Cys Thr Val Arg Arg Val Pro Cys Pro Glu 
        195                 200                 205             

Gly Gln 
    210 

<210>   29
<211>   146
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Furin domain fragment 2

<400>   29
Met Arg Leu Gly Leu Cys Val Val Ala Leu Val Leu Ser Trp Thr His 
1               5                   10                  15      

Leu Thr Ile Ser Ser Arg Gly Ile Lys Gly Lys Arg Gln Arg Arg Ile 
            20                  25                  30          

Ser Ala Glu Gly Ser Gln Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser 
        35                  40                  45              

Glu Val Asn Gly Cys Leu Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu 
    50                  55                  60                  

Glu Arg Asn Asp Ile Arg Gln Val Gly Val Cys Leu Pro Ser Cys Pro 
65                  70                  75                  80  

Pro Gly Tyr Phe Asp Ala Arg Asn Pro Asp Met Asn Lys Cys Ile Lys 
                85                  90                  95      

Cys Lys Ile Glu His Cys Glu Ala Cys Phe Ser His Asn Phe Cys Thr 
            100                 105                 110         

Lys Cys Lys Glu Gly Leu Tyr Leu His Lys Gly Arg Cys Tyr Pro Ala 
        115                 120                 125             

Cys Pro Glu Gly Ser Ser Ala Ala Asn Gly Thr Met Glu Cys Ser Ser 
    130                 135                 140                 

Pro Ala 
145     

<210>   30
<211>   118
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Furin domain fragment 3

<400>   30
Gly Gly Ser Gly Gly Ser Ile Ser Ala Glu Gly Ser Gln Ala Cys Ala 
1               5                   10                  15      

Lys Gly Cys Glu Leu Cys Ser Glu Val Asn Gly Cys Leu Lys Cys Ser 
            20                  25                  30          

Pro Lys Leu Phe Ile Leu Leu Glu Arg Asn Asp Ile Arg Gln Val Gly 
        35                  40                  45              

Val Cys Leu Pro Ser Cys Pro Pro Gly Tyr Phe Ala Arg Asn Pro Asp 
    50                  55                  60                  

Met Asn Lys Cys Ile Lys Cys Lys Ile Glu His Cys Glu Ala Cys Phe 
65                  70                  75                  80  

Ser His Asn Phe Cys Thr Lys Cys Lys Glu Gly Leu Tyr Leu His Lys 
                85                  90                  95      

Gly Arg Cys Tyr Pro Ala Cys Pro Glu Gly Ser Ser Ala Ala Asn Gly 
            100                 105                 110         

Thr Met Glu Cys Ser Ser 
        115             

<210>   31
<211>   100
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Furin domain fragment 4

<400>   31
Ala Glu Gly Ser Gln Ala Cys Ala Lys Gly Cys Glu Leu Cys Ser Glu 
1               5                   10                  15      

Val Asn Gly Cys Leu Lys Cys Ser Pro Lys Leu Phe Ile Leu Leu Glu 
            20                  25                  30          

Arg Asn Asp Ile Arg Gln Val Gly Val Cys Leu Pro Ser Cys Pro Pro 
        35                  40                  45              

Gly Tyr Phe Ala Arg Asn Pro Asp Met Asn Lys Cys Ile Lys Cys Lys 
    50                  55                  60                  

Ile Glu His Cys Glu Ala Cys Phe Ser His Asn Phe Cys Thr Lys Cys 
65                  70                  75                  80  

Lys Glu Gly Leu Tyr Leu His Lys Gly Arg Cys Tyr Pro Ala Cys Pro 
                85                  90                  95      

Glu Gly Ser Ser 
            100 

<210>   32
<211>   105
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   VL antibody

<220>
<221>   Xaa
<222>   4
<223>   Xaa can be any amino acid

<400>   32
Met Thr Gln Xaa Pro Thr Ser Met Ser Ile Ser Ile Gly Asp Arg Val 
1               5                   10                  15      

Thr Met Asn Cys Lys Ala Ser Gln Asn Val Asp Ser Asn Val Asp Trp 
            20                  25                  30          

Tyr Gln Gln Lys Thr Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Ala 
        35                  40                  45              

Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser 
    50                  55                  60                  

Gly Thr Asp Phe Thr Phe Thr Ile Ser Asn Met Gln Ala Glu Asp Leu 
65                  70                  75                  80  

Ala Val Tyr Tyr Cys Met Gln Ser Asn Ser Tyr Pro Leu Thr Phe Gly 
                85                  90                  95      

Ser Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105 

<210>   33
<211>   118
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   VH antibody

<400>   33
Glu Val Lys Leu Gln Glu Ser Gly Ala Ala Leu Val Lys Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          

Tyr Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              

Gly Tyr Ile Asn Pro Asn Ser Gly Tyr Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  

Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  

Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Thr Tyr Tyr Cys 
                85                  90                  95      

Thr Arg Phe Gly Ser Tyr Trp Tyr Phe Asp Phe Trp Gly Gln Gly Thr 
            100                 105                 110         

Thr Val Thr Val Ser Ser 
        115             

