                         SEQUENCE LISTING

<110>  Crucell Holland B.V.
 
<120>  Meningitis B Vaccine

<130>  SMW/FP7153554

<140>
<141>  2015-11-27

<150>  EP 14195507.0
<151>  2014-11-28

<160>  19    

<170>  PatentIn version 3.3

<210>  1
<211>  17
<212>  PRT
<213>  Neisseria meningitidis

<400>  1

Ala Gln Ala Ala Asn Gly Gly Ala Ser Gly Gln Val Lys Val Thr Lys 
1               5                   10                  15      


Ala 
    


<210>  2
<211>  18
<212>  PRT
<213>  Neisseria meningitidis

<400>  2

Gln Pro Ser Lys Ala Gln Gly Gln Thr Asn Asn Gln Val Lys Val Thr 
1               5                   10                  15      


Lys Ala 
        


<210>  3
<211>  14
<212>  PRT
<213>  Neisseria meningitidis

<400>  3

Pro Pro Ser Lys Ser Gln Pro Gln Val Lys Val Thr Lys Ala 
1               5                   10                  


<210>  4
<211>  20
<212>  PRT
<213>  Neisseria meningitidis

<400>  4

Ala Gln Ala Ala Asn Gly Gly Ala Ser Gly Gln Val Lys Val Thr Lys 
1               5                   10                  15      


Val Thr Lys Ala 
            20  


<210>  5
<211>  12
<212>  PRT
<213>  Neisseria meningitidis

<400>  5

Pro Leu Gln Asn Ile Gln Pro Gln Val Thr Lys Arg 
1               5                   10          


<210>  6
<211>  13
<212>  PRT
<213>  Neisseria meningitidis

<400>  6

His Val Val Val Asn Asn Lys Val Ala Thr His Val Pro 
1               5                   10              


<210>  7
<211>  10
<212>  PRT
<213>  Neisseria meningitidis

<400>  7

Tyr Val Asp Glu Lys Lys Met Val His Ala 
1               5                   10  


<210>  8
<211>  13
<212>  PRT
<213>  Neisseria meningitidis

<400>  8

His Tyr Thr Arg Gln Asn Asn Ala Asp Val Phe Val Pro 
1               5                   10              


<210>  9
<211>  14
<212>  PRT
<213>  Neisseria meningitidis

<400>  9

Tyr Tyr Thr Lys Asp Thr Asn Asn Asn Leu Thr Leu Val Pro 
1               5                   10                  


<210>  10
<211>  10
<212>  PRT
<213>  Neisseria meningitidis

<400>  10

Tyr Val Asp Glu Gln Ser Lys Tyr His Ala 
1               5                   10  


<210>  11
<211>  15
<212>  PRT
<213>  Neisseria meningitidis

<400>  11

His Phe Val Gln Gln Thr Pro Lys Ser Gln Pro Thr Leu Val Pro 
1               5                   10                  15  


<210>  12
<211>  32
<212>  PRT
<213>  Neisseria meningitidis

<400>  12

Ser Gln Phe Lys Ile Glu Asp Lys Glu Lys Ala Thr Asp Glu Glu Lys 
1               5                   10                  15      


Asn Lys Asn Arg Glu Asn Glu Lys Ile Ala Lys Ala Tyr Arg Leu Thr 
            20                  25                  30          


<210>  13
<211>  42
<212>  PRT
<213>  Neisseria meningitidis

<400>  13

Gly Lys Phe Lys Ile Ser Asp Lys Lys Pro Asp Pro Asn Asp Pro Thr 
1               5                   10                  15      


Lys Glu Ile Asp Lys Asp Ala Ala Glu Lys Ala Lys Asp Lys Lys Asp 
            20                  25                  30          


Met Asp Leu Val His Ser Tyr Lys Leu Ser 
        35                  40          


<210>  14
<211>  42
<212>  PRT
<213>  Neisseria meningitidis

<400>  14

Gly Glu Phe Glu Ile Ser Gly Lys Lys Lys Asp Pro Lys Asp Pro Lys 
1               5                   10                  15      


Lys Glu Ile Asp Lys Thr Asp Glu Glu Lys Ala Lys Asp Lys Lys Asp 
            20                  25                  30          


Met Asp Leu Val His Ser Tyr Lys Leu Ser 
        35                  40          


<210>  15
<211>  39
<212>  PRT
<213>  Neisseria meningitidis

<400>  15

Ser Lys Phe Ser Ile Pro Thr Thr Glu Glu Lys Asn Gly Gln Lys Val 
1               5                   10                  15      


Asp Lys Pro Met Glu Gln Gln Met Lys Asp Arg Ala Asp Glu Asp Thr 
            20                  25                  30          


Val His Ala Tyr Lys Leu Ser 
        35                  


<210>  16
<211>  42
<212>  PRT
<213>  Neisseria meningitidis

<400>  16

Gly Glu Phe Lys Ile Ser Asp Lys Lys Pro Asp Pro Thr Asp Pro Lys 
1               5                   10                  15      


Lys Glu Ile Ala Lys Thr Asp Glu Glu Lys Ala Lys Asp Lys Ile Asp 
            20                  25                  30          


Met Asp Leu Val His Ser Tyr Lys Leu Ser 
        35                  40          


<210>  17
<211>  40
<212>  PRT
<213>  Neisseria meningitidis

<400>  17

Ser Lys Phe Glu Ile Ser Asp Lys Lys Lys Gly Ala Asp Gly Lys Glu 
1               5                   10                  15      


Val Asp Val Asp Asp Ala Gln Lys Glu Lys Asn Arg Ala Asn Glu Lys 
            20                  25                  30          


Ile Val His Ala Tyr Lys Leu Ser 
        35                  40  


<210>  18
<211>  350
<212>  PRT
<213>  Neisseria meningitidis

<400>  18

Ile Lys Ala Gly Val Glu Gly Arg Asn Ile Gln Leu Gln Leu Thr Glu 
1               5                   10                  15      


Pro Leu Gln Asn Ile Gln Gln Pro Gln Val Thr Lys Arg Lys Ser Arg 
            20                  25                  30          


Ile Arg Thr Lys Ile Ser Asp Phe Gly Ser Phe Ile Gly Phe Lys Gly 
        35                  40                  45              


Ser Glu Asp Leu Gly Glu Gly Leu Lys Ala Val Trp Gln Leu Glu Gln 
    50                  55                  60                  


Asp Val Ser Val Ala Gly Gly Gly Ala Ser Gln Trp Gly Asn Arg Glu 
65                  70                  75                  80  


Ser Phe Ile Gly Leu Ala Gly Glu Phe Gly Thr Leu Arg Ala Gly Arg 
                85                  90                  95      


Val Ala Asn Gln Phe Asp Asp Ala Ser Gln Ala Ile Asp Pro Trp Asp 
            100                 105                 110         


Ser Asn Asn Asp Val Ala Ser Gln Leu Gly Ile Phe Lys Arg His Asp 
        115                 120                 125             


Asp Met Ser Val Ser Val Arg Tyr Asp Ser Pro Glu Phe Ser Gly Phe 
    130                 135                 140                 


Ser Gly Ser Val Gln Phe Val Pro Ala Gln Asn Ser Lys Ser Ala Tyr 
145                 150                 155                 160 


Thr Pro Ala His Phe Val Gln Asn Lys Gln Asn Lys Gln Asn Gln Pro 
                165                 170                 175     


Pro Thr Leu Val Pro Ala Val Val Gly Lys Pro Gly Ser Asp Val Tyr 
            180                 185                 190         


Tyr Ala Gly Leu Asn Tyr Lys Asn Gly Gly Phe Ala Gly Asn Tyr Ala 
        195                 200                 205             


Phe Lys Tyr Ala Lys His Ala Asn Val Gly Arg Asp Ala Phe Glu Leu 
    210                 215                 220                 


Phe Leu Leu Gly Ser Gly Ser Asp Glu Ala Lys Gly Thr Asp Pro Leu 
225                 230                 235                 240 


Lys Asn His Gln Val His Arg Leu Thr Gly Gly Tyr Glu Glu Gly Gly 
                245                 250                 255     


Leu Asn Leu Ala Leu Ala Ala Gln Leu Asp Leu Ser Glu Asn Ala Asp 
            260                 265                 270         


Lys Thr Lys Asn Ser Thr Thr Glu Ile Ala Ala Thr Ala Ser Tyr Arg 
        275                 280                 285             


Phe Gly Asn Ala Val Pro Arg Ile Ser Tyr Ala His Gly Phe Asp Phe 
    290                 295                 300                 


Ile Glu Arg Gly Lys Lys Gly Glu Asn Thr Ser Tyr Asp Gln Ile Ile 
305                 310                 315                 320 


Ala Gly Val Asp Tyr Asp Phe Ser Lys Arg Thr Ser Ala Ile Val Ser 
                325                 330                 335     


Gly Ala Trp Leu Lys Arg Asn Thr Gly Ile Gly Asn Tyr Thr 
            340                 345                 350 


<210>  19
<211>  562
<212>  PRT
<213>  Neisseria meningitidis

<400>  19

Leu Asp Lys Asn Trp Gly Val Arg Leu Asn Ser Gly Phe Ala Ser Asn 
1               5                   10                  15      


Glu Gly Val Ser Tyr Gly Ala Ser Val Phe Gly Lys Glu Gly Asn Phe 
            20                  25                  30          


Asp Gly Leu Phe Ser Tyr Asn Arg Asn Asp Glu Lys Asp Tyr Glu Ala 
        35                  40                  45              


Gly Lys Gly Phe Arg Asn Val Asn Gly Gly Lys Thr Val Pro Tyr Ser 
    50                  55                  60                  


Ala Leu Asp Lys Arg Ser Tyr Leu Ala Lys Ile Gly Thr Thr Phe Gly 
65                  70                  75                  80  


Asp Asp Asp His Arg Ile Val Leu Ser His Met Lys Asp Gln His Arg 
                85                  90                  95      


Gly Ile Arg Thr Val Arg Glu Glu Phe Thr Val Gly Asp Lys Ser Ser 
            100                 105                 110         


Arg Ile Asn Ile Asp Arg Gln Ala Pro Ala Tyr Arg Glu Thr Thr Gln 
        115                 120                 125             


Ser Asn Thr Asn Leu Ala Tyr Thr Gly Lys Asn Leu Gly Phe Val Glu 
    130                 135                 140                 


Lys Leu Asp Ala Asn Ala Tyr Val Leu Glu Lys Glu Arg Tyr Ser Ala 
145                 150                 155                 160 


Asp Asp Ser Gly Thr Gly Tyr Ala Gly Asn Val Lys Gly Pro Asn His 
                165                 170                 175     


Thr Arg Ile Thr Thr Arg Gly Ala Asn Phe Asn Phe Asp Ser Arg Leu 
            180                 185                 190         


Ala Glu Gln Thr Leu Leu Lys Tyr Gly Ile Asn Tyr Arg His Gln Glu 
        195                 200                 205             


Ile Lys Pro Gln Ala Phe Leu Asn Ser Lys Phe Ser Ile Pro Thr Thr 
    210                 215                 220                 


Glu Glu Lys Asn Gly Gln Lys Val Asp Lys Pro Met Glu Gln Gln Met 
225                 230                 235                 240 


Lys Asp Arg Ala Asp Glu Asp Thr Val His Ala Tyr Lys Leu Ser Asn 
                245                 250                 255     


Pro Thr Lys Thr Asp Thr Gly Val Tyr Val Glu Ala Ile His Asp Ile 
            260                 265                 270         


Gly Asp Phe Thr Leu Thr Gly Gly Leu Arg Tyr Asp Arg Phe Lys Val 
        275                 280                 285             


Lys Thr His Asp Gly Lys Thr Val Ser Ser Ser Asn Leu Asn Pro Ser 
    290                 295                 300                 


Phe Gly Val Ile Trp Gln Pro His Glu His Trp Ser Phe Ser Ala Ser 
305                 310                 315                 320 


His Asn Tyr Ala Ser Arg Ser Pro Arg Leu Tyr Asp Ala Leu Gln Thr 
                325                 330                 335     


His Gly Lys Arg Gly Ile Ile Ser Ile Ala Asp Gly Thr Lys Ala Glu 
            340                 345                 350         


Arg Ala Arg Asn Thr Glu Ile Gly Phe Asn Tyr Asn Asp Gly Thr Phe 
        355                 360                 365             


Ala Ala Asn Gly Ser Tyr Phe Trp Gln Thr Ile Lys Asp Ala Leu Ala 
    370                 375                 380                 


Asn Pro Gln Asn Arg His Asp Ser Val Ala Val Arg Glu Ala Val Asn 
385                 390                 395                 400 


Ala Gly Tyr Ile Lys Asn His Gly Tyr Glu Leu Gly Ala Ser Tyr Arg 
                405                 410                 415     


Thr Gly Gly Leu Thr Ala Lys Val Gly Val Ser His Ser Lys Pro Arg 
            420                 425                 430         


Phe Tyr Asp Thr His Lys Asp Lys Leu Leu Ser Ala Asn Pro Glu Phe 
        435                 440                 445             


Gly Ala Gln Val Gly Arg Thr Trp Thr Ala Ser Leu Ala Tyr Arg Phe 
    450                 455                 460                 


Gln Asn Pro Asn Leu Glu Ile Gly Trp Arg Gly Arg Tyr Val Gln Lys 
465                 470                 475                 480 


Ala Thr Gly Ser Ile Leu Ala Ala Gly Gln Lys Asp Arg Lys Gly Asn 
                485                 490                 495     


Leu Glu Asn Val Val Arg Lys Gly Phe Gly Val Asn Asp Val Phe Ala 
            500                 505                 510         


Asn Trp Lys Pro Leu Gly Lys Asp Thr Leu Asn Val Asn Leu Ser Val 
        515                 520                 525             


Asn Asn Val Phe Asn Lys Phe Tyr Tyr Pro His Ser Gln Arg Trp Thr 
    530                 535                 540                 


Asn Thr Leu Pro Gly Val Gly Arg Asp Val Arg Leu Gly Val Asn Tyr 
545                 550                 555                 560 


Lys Phe 
        


