                         SEQUENCE LISTING

<110>  Synageva BioPharma Corp.
 
<120>  RECOMBINANT HUMAN ADA2 AND ADA2 FUSION PROTEINS AND METHODS FOR 
       TREATING ADA2 DEFICIENCIES

<130>  121424-03620

<150>  62/080,588
<151>  2014-11-17

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  511
<212>  PRT
<213>  Homo Sapiens

<400>  1

Met Leu Val Asp Gly Pro Ser Glu Arg Pro Ala Leu Cys Phe Leu Leu 
1               5                   10                  15      


Leu Ala Val Ala Met Ser Phe Phe Gly Ser Ala Leu Ser Ile Asp Glu 
            20                  25                  30          


Thr Arg Ala His Leu Leu Leu Lys Glu Lys Met Met Arg Leu Gly Gly 
        35                  40                  45              


Arg Leu Val Leu Asn Thr Lys Glu Glu Leu Ala Asn Glu Arg Leu Met 
    50                  55                  60                  


Thr Leu Lys Ile Ala Glu Met Lys Glu Ala Met Arg Thr Leu Ile Phe 
65                  70                  75                  80  


Pro Pro Ser Met His Phe Phe Gln Ala Lys His Leu Ile Glu Arg Ser 
                85                  90                  95      


Gln Val Phe Asn Ile Leu Arg Met Met Pro Lys Gly Ala Ala Leu His 
            100                 105                 110         


Leu His Asp Ile Gly Ile Val Thr Met Asp Trp Leu Val Arg Asn Val 
        115                 120                 125             


Thr Tyr Arg Pro His Cys His Ile Cys Phe Thr Pro Arg Gly Ile Met 
    130                 135                 140                 


Gln Phe Arg Phe Ala His Pro Thr Pro Arg Pro Ser Glu Lys Cys Ser 
145                 150                 155                 160 


Lys Trp Ile Leu Leu Glu Asp Tyr Arg Lys Arg Val Gln Asn Val Thr 
                165                 170                 175     


Glu Phe Asp Asp Ser Leu Leu Arg Asn Phe Thr Leu Val Thr Gln His 
            180                 185                 190         


Pro Glu Val Ile Tyr Thr Asn Gln Asn Val Val Trp Ser Lys Phe Glu 
        195                 200                 205             


Thr Ile Phe Phe Thr Ile Ser Gly Leu Ile His Tyr Ala Pro Val Phe 
    210                 215                 220                 


Arg Asp Tyr Val Phe Arg Ser Met Gln Glu Phe Tyr Glu Asp Asn Val 
225                 230                 235                 240 


Leu Tyr Met Glu Ile Arg Ala Arg Leu Leu Pro Val Tyr Glu Leu Ser 
                245                 250                 255     


Gly Glu His His Asp Glu Glu Trp Ser Val Lys Thr Tyr Gln Glu Val 
            260                 265                 270         


Ala Gln Lys Phe Val Glu Thr His Pro Glu Phe Ile Gly Ile Lys Ile 
        275                 280                 285             


Ile Tyr Ser Asp His Arg Ser Lys Asp Val Ala Val Ile Ala Glu Ser 
    290                 295                 300                 


Ile Arg Met Ala Met Gly Leu Arg Ile Lys Phe Pro Thr Val Val Ala 
305                 310                 315                 320 


Gly Phe Asp Leu Val Gly His Glu Asp Thr Gly His Ser Leu His Asp 
                325                 330                 335     


Tyr Lys Glu Ala Leu Met Ile Pro Ala Lys Asp Gly Val Lys Leu Pro 
            340                 345                 350         


Tyr Phe Phe His Ala Gly Glu Thr Asp Trp Gln Gly Thr Ser Ile Asp 
        355                 360                 365             


Arg Asn Ile Leu Asp Ala Leu Met Leu Asn Thr Thr Arg Ile Gly His 
    370                 375                 380                 


Gly Phe Ala Leu Ser Lys His Pro Ala Val Arg Thr Tyr Ser Trp Lys 
385                 390                 395                 400 


Lys Asp Ile Pro Ile Glu Val Cys Pro Ile Ser Asn Gln Val Leu Lys 
                405                 410                 415     


Leu Val Ser Asp Leu Arg Asn His Pro Val Ala Thr Leu Met Ala Thr 
            420                 425                 430         


Gly His Pro Met Val Ile Ser Ser Asp Asp Pro Ala Met Phe Gly Ala 
        435                 440                 445             


Lys Gly Leu Ser Tyr Asp Phe Tyr Glu Val Phe Met Gly Ile Gly Gly 
    450                 455                 460                 


Met Lys Ala Asp Leu Arg Thr Leu Lys Gln Leu Ala Met Asn Ser Ile 
465                 470                 475                 480 


Lys Tyr Ser Thr Leu Leu Glu Ser Glu Lys Asn Thr Phe Met Glu Ile 
                485                 490                 495     


Trp Lys Lys Arg Trp Asp Lys Phe Ile Ala Asp Val Ala Thr Lys 
            500                 505                 510     


<210>  2
<211>  1536
<212>  DNA
<213>  Homo Sapiens

<400>  2
atgttggtgg atggcccatc tgagcggcca gccctgtgct tcttgctgtt ggctgtggca       60

atgtctttct tcggctcagc tctatccata gatgaaacac gggcgcatct gttgttgaaa      120

gaaaagatga tgcggctggg ggggcggctg gtgctgaaca ccaaggagga gctggccaat      180

gagaggctca tgacgctcaa aatcgctgag atgaaggagg ccatgaggac cctgatattc      240

ccacccagca tgcacttttt ccaggccaag catctcattg agagaagtca agtgtttaat      300

attctaagga tgatgccaaa aggggctgcc ttgcacctcc atgacattgg catcgtgact      360

atggactggc tggtgaggaa tgtcacctac aggcctcact gccacatctg tttcacccca      420

agggggatca tgcagttcag atttgctcac ccaactcccc gtccatcaga aaaatgttcc      480

aagtggattc tgctggagga ttatcggaag cgggtgcaga acgtcactga gtttgatgac      540

agcttgctga ggaatttcac tctggtgacc cagcacccgg aggtgattta cacaaaccaa      600

aatgttgtct ggtcgaaatt tgaaaccatc ttcttcacca tctctggtct catccattac      660

gcaccagtgt tcagagacta tgtcttccgg agcatgcagg agttctacga ggacaacgtg      720

ctctacatgg agatcagagc caggctgctg ccggtgtatg agctcagtgg agagcaccat      780

gacgaagagt ggtcagtgaa gacttaccag gaagtagctc agaagtttgt ggaaactcac      840

cctgagttta ttggaatcaa aatcatttat tcggatcaca gatccaaaga tgtggctgtc      900

atcgcagaat ccatccgaat ggccatgggg ctccgaatca agttccccac ggtggtggca      960

gggtttgacc tggtggggca tgaggacact ggccactcct tgcatgacta caaggaagct     1020

ctgatgatcc ccgccaagga tggcgttaag ctgccttact tcttccacgc cggagaaaca     1080

gactggcagg gtacttccat agacaggaac attctggatg ctctgatgct gaacactacc     1140

agaatcggcc atggatttgc tttgagcaaa caccccgcag tcaggactta ctcctggaaa     1200

aaggacatcc ccatagaagt ctgtcccatc tctaaccagg tgctgaaact ggtgtctgac     1260

ttgaggaacc accctgtagc cactctgatg gccactgggc accccatggt gatcagctct     1320

gatgacccag ctatgtttgg tgccaaaggc ttgtcctatg atttctatga ggtcttcatg     1380

ggcattgggg ggatgaaggc tgacctgagg accctcaaac agctggccat gaactctatc     1440

aagtacagta ccctgttgga gagtgagaaa aatactttca tggaaatctg gaagaagaga     1500

tgggataagt tcatagcaga tgtggctaca aagtga                               1536


<210>  3
<211>  511
<212>  PRT
<213>  Synthetic

<400>  3

Met Leu Val Asp Gly Pro Ser Glu Arg Pro Ala Leu Cys Phe Leu Leu 
1               5                   10                  15      


Leu Ala Val Ala Met Ser Phe Phe Gly Ser Ala Leu Ser Ile Asp Glu 
            20                  25                  30          


Thr Arg Ala His Leu Leu Leu Lys Glu Lys Met Met Arg Leu Gly Gly 
        35                  40                  45              


Arg Leu Val Leu Asn Thr Lys Glu Glu Leu Ala Asn Glu Arg Leu Met 
    50                  55                  60                  


Thr Leu Lys Ile Ala Glu Met Lys Glu Ala Met Arg Thr Leu Ile Phe 
65                  70                  75                  80  


Pro Pro Ser Met His Phe Phe Gln Ala Lys His Leu Ile Glu Arg Ser 
                85                  90                  95      


Gln Val Phe Asn Ile Leu Arg Met Met Pro Lys Gly Ala Ala Leu His 
            100                 105                 110         


Leu His Asp Ile Gly Ile Val Thr Met Asp Trp Leu Val Arg Ala Val 
        115                 120                 125             


Thr Tyr Arg Pro His Cys His Ile Cys Phe Thr Pro Arg Gly Ile Met 
    130                 135                 140                 


Gln Phe Arg Phe Ala His Pro Thr Pro Arg Pro Ser Glu Lys Cys Ser 
145                 150                 155                 160 


Lys Trp Ile Leu Leu Glu Asp Tyr Arg Lys Arg Val Gln Asn Val Thr 
                165                 170                 175     


Glu Phe Asp Asp Ser Leu Leu Arg Asn Phe Thr Leu Val Thr Gln His 
            180                 185                 190         


Pro Glu Val Ile Tyr Thr Asn Gln Asn Val Val Trp Ser Lys Phe Glu 
        195                 200                 205             


Thr Ile Phe Phe Thr Ile Ser Gly Leu Ile His Tyr Ala Pro Val Phe 
    210                 215                 220                 


Arg Asp Tyr Val Phe Arg Ser Met Gln Glu Phe Tyr Glu Asp Asn Val 
225                 230                 235                 240 


Leu Tyr Met Glu Ile Arg Ala Arg Leu Leu Pro Val Tyr Glu Leu Ser 
                245                 250                 255     


Gly Glu His His Asp Glu Glu Trp Ser Val Lys Thr Tyr Gln Glu Val 
            260                 265                 270         


Ala Gln Lys Phe Val Glu Thr His Pro Glu Phe Ile Gly Ile Lys Ile 
        275                 280                 285             


Ile Tyr Ser Asp His Arg Ser Lys Asp Val Ala Val Ile Ala Glu Ser 
    290                 295                 300                 


Ile Arg Met Ala Met Gly Leu Arg Ile Lys Phe Pro Thr Val Val Ala 
305                 310                 315                 320 


Gly Phe Asp Leu Val Gly His Glu Asp Thr Gly His Ser Leu His Asp 
                325                 330                 335     


Tyr Lys Glu Ala Leu Met Ile Pro Ala Lys Asp Gly Val Lys Leu Pro 
            340                 345                 350         


Tyr Phe Phe His Ala Gly Glu Thr Asp Trp Gln Gly Thr Ser Ile Asp 
        355                 360                 365             


Arg Asn Ile Leu Asp Ala Leu Met Leu Asn Thr Thr Arg Ile Gly His 
    370                 375                 380                 


Gly Phe Ala Leu Ser Lys His Pro Ala Val Arg Thr Tyr Ser Trp Lys 
385                 390                 395                 400 


Lys Asp Ile Pro Ile Glu Val Cys Pro Ile Ser Asn Gln Val Leu Lys 
                405                 410                 415     


Leu Val Ser Asp Leu Arg Asn His Pro Val Ala Thr Leu Met Ala Thr 
            420                 425                 430         


Gly His Pro Met Val Ile Ser Ser Asp Asp Pro Ala Met Phe Gly Ala 
        435                 440                 445             


Lys Gly Leu Ser Tyr Asp Phe Tyr Glu Val Phe Met Gly Ile Gly Gly 
    450                 455                 460                 


Met Lys Ala Asp Leu Arg Thr Leu Lys Gln Leu Ala Met Asn Ser Ile 
465                 470                 475                 480 


Lys Tyr Ser Thr Leu Leu Glu Ser Glu Lys Asn Thr Phe Met Glu Ile 
                485                 490                 495     


Trp Lys Lys Arg Trp Asp Lys Phe Ile Ala Asp Val Ala Thr Lys 
            500                 505                 510     


<210>  4
<211>  1536
<212>  DNA
<213>  Homo sapiens

<400>  4
atgttggtgg atggcccatc tgagcggcca gccctgtgct tcttgctgtt ggctgtggca       60

atgtctttct tcggctctgc tctatccata gatgaaacac gggcgcatct gttgttgaaa      120

gaaaagatga tgcggctggg ggggcggctg gtgctgaaca ccaaggagga gctggccaat      180

gagaggctca tgacgctcaa aatcgctgag atgaaggagg ccatgaggac cctgatattc      240

ccacccagca tgcacttttt ccaggccaag catctcattg agagaagtca agtgtttaat      300

attctaagga tgatgccaaa aggggctgcc ttgcacctcc atgacattgg catcgtgact      360

atggactggc tggtgagggc cgtcacctac aggcctcact gccacatctg tttcacccca      420

agggggatca tgcagttcag atttgctcac ccaactcccc gtccatcaga aaaatgttcc      480

aagtggattc tgctggagga ttatcggaag cgggtgcaga acgtcactga gtttgatgac      540

agcttgctga ggaatttcac tctggtgacc cagcacccgg aggtgattta cacaaaccaa      600

aatgttgtct ggtcgaaatt tgaaaccatc ttcttcacca tctctggtct catccattac      660

gctccagtgt tcagagacta tgtcttccgg agcatgcagg agttctacga ggacaacgtg      720

ctctacatgg agatcagagc caggctgctg ccggtgtatg agctcagtgg agagcaccat      780

gacgaagagt ggtcagtgaa gacttatcag gaagtagctc agaagtttgt ggaaactcat      840

cctgagttta ttggaatcaa aatcatttat tcggatcaca gatccaaaga tgtggctgtc      900

atcgcagaat ccatccgaat ggccatgggg ctccgaatca agttccccac ggtggtggca      960

gggtttgacc tggtggggca tgaggacact ggccactcct tgcatgacta caaggaagct     1020

ctgatgatcc ccgccaagga tggcgttaag ctgccttact tcttccacgc cggagaaaca     1080

gactggcagg gtacttccat agacaggaac attctggatg ctctgatgct gaacactacc     1140

agaatcggcc atggatttgc tttgagcaaa caccccgcag tcaggactta ttcctggaaa     1200

aaggacatcc ccatagaagt ctgtcccatc tctaaccagg tgctgaaact ggtgtctgac     1260

ttgaggaacc accctgtagc cactctgatg gccactgggc accccatggt gatcagctct     1320

gatgacccag ctatgtttgg tgccaaaggc ttgtcctatg atttctatga ggtcttcatg     1380

ggcattgggg ggatgaaggc tgatctgagg accctcaaac agctggccat gaactctatc     1440

aagtacagta ccctgttgga gagtgagaaa aatactttca tggaaatatg gaagaagaga     1500

tgggataagt tcatagcaga tgtggctaca aagtga                               1536


<210>  5
<211>  511
<212>  PRT
<213>  Synthetic

<400>  5

Met Leu Val Asp Gly Pro Ser Glu Arg Pro Ala Leu Cys Phe Leu Leu 
1               5                   10                  15      


Leu Ala Val Ala Met Ser Phe Phe Gly Ser Ala Leu Ser Ile Asp Glu 
            20                  25                  30          


Thr Arg Ala His Leu Leu Leu Lys Glu Lys Met Met Arg Leu Gly Gly 
        35                  40                  45              


Arg Leu Val Leu Asn Thr Lys Glu Glu Leu Ala Asn Glu Arg Leu Met 
    50                  55                  60                  


Thr Leu Lys Ile Ala Glu Met Lys Glu Ala Met Arg Thr Leu Ile Phe 
65                  70                  75                  80  


Pro Pro Ser Met His Phe Phe Gln Ala Lys His Leu Ile Glu Arg Ser 
                85                  90                  95      


Gln Val Phe Asn Ile Leu Arg Met Met Pro Lys Gly Ala Ala Leu His 
            100                 105                 110         


Leu His Asp Ile Gly Ile Val Thr Met Asp Trp Leu Val Arg Asn Val 
        115                 120                 125             


Thr Tyr Arg Pro His Cys His Ile Cys Phe Thr Pro Arg Gly Ile Met 
    130                 135                 140                 


Gln Phe Arg Phe Ala His Pro Thr Pro Arg Pro Ser Glu Lys Cys Ser 
145                 150                 155                 160 


Lys Trp Ile Leu Leu Glu Asp Tyr Arg Lys Arg Val Gln Ala Val Thr 
                165                 170                 175     


Glu Phe Asp Asp Ser Leu Leu Arg Asn Phe Thr Leu Val Thr Gln His 
            180                 185                 190         


Pro Glu Val Ile Tyr Thr Asn Gln Asn Val Val Trp Ser Lys Phe Glu 
        195                 200                 205             


Thr Ile Phe Phe Thr Ile Ser Gly Leu Ile His Tyr Ala Pro Val Phe 
    210                 215                 220                 


Arg Asp Tyr Val Phe Arg Ser Met Gln Glu Phe Tyr Glu Asp Asn Val 
225                 230                 235                 240 


Leu Tyr Met Glu Ile Arg Ala Arg Leu Leu Pro Val Tyr Glu Leu Ser 
                245                 250                 255     


Gly Glu His His Asp Glu Glu Trp Ser Val Lys Thr Tyr Gln Glu Val 
            260                 265                 270         


Ala Gln Lys Phe Val Glu Thr His Pro Glu Phe Ile Gly Ile Lys Ile 
        275                 280                 285             


Ile Tyr Ser Asp His Arg Ser Lys Asp Val Ala Val Ile Ala Glu Ser 
    290                 295                 300                 


Ile Arg Met Ala Met Gly Leu Arg Ile Lys Phe Pro Thr Val Val Ala 
305                 310                 315                 320 


Gly Phe Asp Leu Val Gly His Glu Asp Thr Gly His Ser Leu His Asp 
                325                 330                 335     


Tyr Lys Glu Ala Leu Met Ile Pro Ala Lys Asp Gly Val Lys Leu Pro 
            340                 345                 350         


Tyr Phe Phe His Ala Gly Glu Thr Asp Trp Gln Gly Thr Ser Ile Asp 
        355                 360                 365             


Arg Asn Ile Leu Asp Ala Leu Met Leu Asn Thr Thr Arg Ile Gly His 
    370                 375                 380                 


Gly Phe Ala Leu Ser Lys His Pro Ala Val Arg Thr Tyr Ser Trp Lys 
385                 390                 395                 400 


Lys Asp Ile Pro Ile Glu Val Cys Pro Ile Ser Asn Gln Val Leu Lys 
                405                 410                 415     


Leu Val Ser Asp Leu Arg Asn His Pro Val Ala Thr Leu Met Ala Thr 
            420                 425                 430         


Gly His Pro Met Val Ile Ser Ser Asp Asp Pro Ala Met Phe Gly Ala 
        435                 440                 445             


Lys Gly Leu Ser Tyr Asp Phe Tyr Glu Val Phe Met Gly Ile Gly Gly 
    450                 455                 460                 


Met Lys Ala Asp Leu Arg Thr Leu Lys Gln Leu Ala Met Asn Ser Ile 
465                 470                 475                 480 


Lys Tyr Ser Thr Leu Leu Glu Ser Glu Lys Asn Thr Phe Met Glu Ile 
                485                 490                 495     


Trp Lys Lys Arg Trp Asp Lys Phe Ile Ala Asp Val Ala Thr Lys 
            500                 505                 510     


<210>  6
<211>  1536
<212>  DNA
<213>  Synthetic

<400>  6
atgttggtgg atggcccatc tgagcggcca gccctgtgct tcttgctgtt ggctgtggca       60

atgtctttct tcggctctgc tctatccata gatgaaacac gggcgcatct gttgttgaaa      120

gaaaagatga tgcggctggg ggggcggctg gtgctgaaca ccaaggagga gctggccaat      180

gagaggctca tgacgctcaa aatcgctgag atgaaggagg ccatgaggac cctgatattc      240

ccacccagca tgcacttttt ccaggccaag catctcattg agagaagtca agtgtttaat      300

attctaagga tgatgccaaa aggggctgcc ttgcacctcc atgacattgg catcgtgact      360

atggactggc tggtgaggaa tgtcacctac aggcctcact gccacatctg tttcacccca      420

agggggatca tgcagttcag atttgctcac ccaactcccc gtccatcaga aaaatgttcc      480

aagtggattc tgctggagga ttatcggaag cgggtgcagg ccgtcactga gtttgatgac      540

agcttgctga ggaatttcac tctggtgacc cagcacccgg aggtgattta cacaaaccaa      600

aatgttgtct ggtcgaaatt tgaaaccatc ttcttcacca tctctggtct catccattac      660

gctccagtgt tcagagacta tgtcttccgg agcatgcagg agttctacga ggacaacgtg      720

ctctacatgg agatcagagc caggctgctg ccggtgtatg agctcagtgg agagcaccat      780

gacgaagagt ggtcagtgaa gacttatcag gaagtagctc agaagtttgt ggaaactcat      840

cctgagttta ttggaatcaa aatcatttat tcggatcaca gatccaaaga tgtggctgtc      900

atcgcagaat ccatccgaat ggccatgggg ctccgaatca agttccccac ggtggtggca      960

gggtttgacc tggtggggca tgaggacact ggccactcct tgcatgacta caaggaagct     1020

ctgatgatcc ccgccaagga tggcgttaag ctgccttact tcttccacgc cggagaaaca     1080

gactggcagg gtacttccat agacaggaac attctggatg ctctgatgct gaacactacc     1140

agaatcggcc atggatttgc tttgagcaaa caccccgcag tcaggactta ttcctggaaa     1200

aaggacatcc ccatagaagt ctgtcccatc tctaaccagg tgctgaaact ggtgtctgac     1260

ttgaggaacc accctgtagc cactctgatg gccactgggc accccatggt gatcagctct     1320

gatgacccag ctatgtttgg tgccaaaggc ttgtcctatg atttctatga ggtcttcatg     1380

ggcattgggg ggatgaaggc tgatctgagg accctcaaac agctggccat gaactctatc     1440

aagtacagta ccctgttgga gagtgagaaa aatactttca tggaaatatg gaagaagaga     1500

tgggataagt tcatagcaga tgtggctaca aagtga                               1536


<210>  7
<211>  511
<212>  PRT
<213>  Synthetic

<400>  7

Met Leu Val Asp Gly Pro Ser Glu Arg Pro Ala Leu Cys Phe Leu Leu 
1               5                   10                  15      


Leu Ala Val Ala Met Ser Phe Phe Gly Ser Ala Leu Ser Ile Asp Glu 
            20                  25                  30          


Thr Arg Ala His Leu Leu Leu Lys Glu Lys Met Met Arg Leu Gly Gly 
        35                  40                  45              


Arg Leu Val Leu Asn Thr Lys Glu Glu Leu Ala Asn Glu Arg Leu Met 
    50                  55                  60                  


Thr Leu Lys Ile Ala Glu Met Lys Glu Ala Met Arg Thr Leu Ile Phe 
65                  70                  75                  80  


Pro Pro Ser Met His Phe Phe Gln Ala Lys His Leu Ile Glu Arg Ser 
                85                  90                  95      


Gln Val Phe Asn Ile Leu Arg Met Met Pro Lys Gly Ala Ala Leu His 
            100                 105                 110         


Leu His Asp Ile Gly Ile Val Thr Met Asp Trp Leu Val Arg Asn Val 
        115                 120                 125             


Thr Tyr Arg Pro His Cys His Ile Cys Phe Thr Pro Arg Gly Ile Met 
    130                 135                 140                 


Gln Phe Arg Phe Ala His Pro Thr Pro Arg Pro Ser Glu Lys Cys Ser 
145                 150                 155                 160 


Lys Trp Ile Leu Leu Glu Asp Tyr Arg Lys Arg Val Gln Asn Val Thr 
                165                 170                 175     


Glu Phe Asp Asp Ser Leu Leu Arg Ala Phe Thr Leu Val Thr Gln His 
            180                 185                 190         


Pro Glu Val Ile Tyr Thr Asn Gln Asn Val Val Trp Ser Lys Phe Glu 
        195                 200                 205             


Thr Ile Phe Phe Thr Ile Ser Gly Leu Ile His Tyr Ala Pro Val Phe 
    210                 215                 220                 


Arg Asp Tyr Val Phe Arg Ser Met Gln Glu Phe Tyr Glu Asp Asn Val 
225                 230                 235                 240 


Leu Tyr Met Glu Ile Arg Ala Arg Leu Leu Pro Val Tyr Glu Leu Ser 
                245                 250                 255     


Gly Glu His His Asp Glu Glu Trp Ser Val Lys Thr Tyr Gln Glu Val 
            260                 265                 270         


Ala Gln Lys Phe Val Glu Thr His Pro Glu Phe Ile Gly Ile Lys Ile 
        275                 280                 285             


Ile Tyr Ser Asp His Arg Ser Lys Asp Val Ala Val Ile Ala Glu Ser 
    290                 295                 300                 


Ile Arg Met Ala Met Gly Leu Arg Ile Lys Phe Pro Thr Val Val Ala 
305                 310                 315                 320 


Gly Phe Asp Leu Val Gly His Glu Asp Thr Gly His Ser Leu His Asp 
                325                 330                 335     


Tyr Lys Glu Ala Leu Met Ile Pro Ala Lys Asp Gly Val Lys Leu Pro 
            340                 345                 350         


Tyr Phe Phe His Ala Gly Glu Thr Asp Trp Gln Gly Thr Ser Ile Asp 
        355                 360                 365             


Arg Asn Ile Leu Asp Ala Leu Met Leu Asn Thr Thr Arg Ile Gly His 
    370                 375                 380                 


Gly Phe Ala Leu Ser Lys His Pro Ala Val Arg Thr Tyr Ser Trp Lys 
385                 390                 395                 400 


Lys Asp Ile Pro Ile Glu Val Cys Pro Ile Ser Asn Gln Val Leu Lys 
                405                 410                 415     


Leu Val Ser Asp Leu Arg Asn His Pro Val Ala Thr Leu Met Ala Thr 
            420                 425                 430         


Gly His Pro Met Val Ile Ser Ser Asp Asp Pro Ala Met Phe Gly Ala 
        435                 440                 445             


Lys Gly Leu Ser Tyr Asp Phe Tyr Glu Val Phe Met Gly Ile Gly Gly 
    450                 455                 460                 


Met Lys Ala Asp Leu Arg Thr Leu Lys Gln Leu Ala Met Asn Ser Ile 
465                 470                 475                 480 


Lys Tyr Ser Thr Leu Leu Glu Ser Glu Lys Asn Thr Phe Met Glu Ile 
                485                 490                 495     


Trp Lys Lys Arg Trp Asp Lys Phe Ile Ala Asp Val Ala Thr Lys 
            500                 505                 510     


<210>  8
<211>  1536
<212>  DNA
<213>  Synthetic

<400>  8
atgttggtgg atggcccatc tgagcggcca gccctgtgct tcttgctgtt ggctgtggca       60

atgtctttct tcggctctgc tctatccata gatgaaacac gggcgcatct gttgttgaaa      120

gaaaagatga tgcggctggg ggggcggctg gtgctgaaca ccaaggagga gctggccaat      180

gagaggctca tgacgctcaa aatcgctgag atgaaggagg ccatgaggac cctgatattc      240

ccacccagca tgcacttttt ccaggccaag catctcattg agagaagtca agtgtttaat      300

attctaagga tgatgccaaa aggggctgcc ttgcacctcc atgacattgg catcgtgact      360

atggactggc tggtgaggaa tgtcacctac aggcctcact gccacatctg tttcacccca      420

agggggatca tgcagttcag atttgctcac ccaactcccc gtccatcaga aaaatgttcc      480

aagtggattc tgctggagga ttatcggaag cgggtgcaga acgtcactga gtttgatgac      540

agcttgctga gggccttcac tctggtgacc cagcacccgg aggtgattta cacaaaccaa      600

aatgttgtct ggtcgaaatt tgaaaccatc ttcttcacca tctctggtct catccattac      660

gctccagtgt tcagagacta tgtcttccgg agcatgcagg agttctacga ggacaacgtg      720

ctctacatgg agatcagagc caggctgctg ccggtgtatg agctcagtgg agagcaccat      780

gacgaagagt ggtcagtgaa gacttatcag gaagtagctc agaagtttgt ggaaactcat      840

cctgagttta ttggaatcaa aatcatttat tcggatcaca gatccaaaga tgtggctgtc      900

atcgcagaat ccatccgaat ggccatgggg ctccgaatca agttccccac ggtggtggca      960

gggtttgacc tggtggggca tgaggacact ggccactcct tgcatgacta caaggaagct     1020

ctgatgatcc ccgccaagga tggcgttaag ctgccttact tcttccacgc cggagaaaca     1080

gactggcagg gtacttccat agacaggaac attctggatg ctctgatgct gaacactacc     1140

agaatcggcc atggatttgc tttgagcaaa caccccgcag tcaggactta ttcctggaaa     1200

aaggacatcc ccatagaagt ctgtcccatc tctaaccagg tgctgaaact ggtgtctgac     1260

ttgaggaacc accctgtagc cactctgatg gccactgggc accccatggt gatcagctct     1320

gatgacccag ctatgtttgg tgccaaaggc ttgtcctatg atttctatga ggtcttcatg     1380

ggcattgggg ggatgaaggc tgatctgagg accctcaaac agctggccat gaactctatc     1440

aagtacagta ccctgttgga gagtgagaaa aatactttca tggaaatatg gaagaagaga     1500

tgggataagt tcatagcaga tgtggctaca aagtga                               1536


<210>  9
<211>  511
<212>  PRT
<213>  Synthetic

<400>  9

Met Leu Val Asp Gly Pro Ser Glu Arg Pro Ala Leu Cys Phe Leu Leu 
1               5                   10                  15      


Leu Ala Val Ala Met Ser Phe Phe Gly Ser Ala Leu Ser Ile Asp Glu 
            20                  25                  30          


Thr Arg Ala His Leu Leu Leu Lys Glu Lys Met Met Arg Leu Gly Gly 
        35                  40                  45              


Arg Leu Val Leu Asn Thr Lys Glu Glu Leu Ala Asn Glu Arg Leu Met 
    50                  55                  60                  


Thr Leu Lys Ile Ala Glu Met Lys Glu Ala Met Arg Thr Leu Ile Phe 
65                  70                  75                  80  


Pro Pro Ser Met His Phe Phe Gln Ala Lys His Leu Ile Glu Arg Ser 
                85                  90                  95      


Gln Val Phe Asn Ile Leu Arg Met Met Pro Lys Gly Ala Ala Leu His 
            100                 105                 110         


Leu His Asp Ile Gly Ile Val Thr Met Asp Trp Leu Val Arg Asn Val 
        115                 120                 125             


Thr Tyr Arg Pro His Cys His Ile Cys Phe Thr Pro Arg Gly Ile Met 
    130                 135                 140                 


Gln Phe Arg Phe Ala His Pro Thr Pro Arg Pro Ser Glu Lys Cys Ser 
145                 150                 155                 160 


Lys Trp Ile Leu Leu Glu Asp Tyr Arg Lys Arg Val Gln Asn Val Thr 
                165                 170                 175     


Glu Phe Asp Asp Ser Leu Leu Arg Asn Phe Thr Leu Val Thr Gln His 
            180                 185                 190         


Pro Glu Val Ile Tyr Thr Asn Gln Asn Val Val Trp Ser Lys Phe Glu 
        195                 200                 205             


Thr Ile Phe Phe Thr Ile Ser Gly Leu Ile His Tyr Ala Pro Val Phe 
    210                 215                 220                 


Arg Asp Tyr Val Phe Arg Ser Met Gln Glu Phe Tyr Glu Asp Asn Val 
225                 230                 235                 240 


Leu Tyr Met Glu Ile Arg Ala Arg Leu Leu Pro Val Tyr Glu Leu Ser 
                245                 250                 255     


Gly Glu His His Asp Glu Glu Trp Ser Val Lys Thr Tyr Gln Glu Val 
            260                 265                 270         


Ala Gln Lys Phe Val Glu Thr His Pro Glu Phe Ile Gly Ile Lys Ile 
        275                 280                 285             


Ile Tyr Ser Asp His Arg Ser Lys Asp Val Ala Val Ile Ala Glu Ser 
    290                 295                 300                 


Ile Arg Met Ala Met Gly Leu Arg Ile Lys Phe Pro Thr Val Val Ala 
305                 310                 315                 320 


Gly Phe Asp Leu Val Gly His Glu Asp Thr Gly His Ser Leu His Asp 
                325                 330                 335     


Tyr Lys Glu Ala Leu Met Ile Pro Ala Lys Asp Gly Val Lys Leu Pro 
            340                 345                 350         


Tyr Phe Phe His Ala Gly Glu Thr Asp Trp Gln Gly Thr Ser Ile Asp 
        355                 360                 365             


Arg Asn Ile Leu Asp Ala Leu Met Leu Ala Thr Thr Arg Ile Gly His 
    370                 375                 380                 


Gly Phe Ala Leu Ser Lys His Pro Ala Val Arg Thr Tyr Ser Trp Lys 
385                 390                 395                 400 


Lys Asp Ile Pro Ile Glu Val Cys Pro Ile Ser Asn Gln Val Leu Lys 
                405                 410                 415     


Leu Val Ser Asp Leu Arg Asn His Pro Val Ala Thr Leu Met Ala Thr 
            420                 425                 430         


Gly His Pro Met Val Ile Ser Ser Asp Asp Pro Ala Met Phe Gly Ala 
        435                 440                 445             


Lys Gly Leu Ser Tyr Asp Phe Tyr Glu Val Phe Met Gly Ile Gly Gly 
    450                 455                 460                 


Met Lys Ala Asp Leu Arg Thr Leu Lys Gln Leu Ala Met Asn Ser Ile 
465                 470                 475                 480 


Lys Tyr Ser Thr Leu Leu Glu Ser Glu Lys Asn Thr Phe Met Glu Ile 
                485                 490                 495     


Trp Lys Lys Arg Trp Asp Lys Phe Ile Ala Asp Val Ala Thr Lys 
            500                 505                 510     


<210>  10
<211>  1536
<212>  DNA
<213>  Synthetic

<400>  10
atgttggtgg atggcccatc tgagcggcca gccctgtgct tcttgctgtt ggctgtggca       60

atgtctttct tcggctctgc tctatccata gatgaaacac gggcgcatct gttgttgaaa      120

gaaaagatga tgcggctggg ggggcggctg gtgctgaaca ccaaggagga gctggccaat      180

gagaggctca tgacgctcaa aatcgctgag atgaaggagg ccatgaggac cctgatattc      240

ccacccagca tgcacttttt ccaggccaag catctcattg agagaagtca agtgtttaat      300

attctaagga tgatgccaaa aggggctgcc ttgcacctcc atgacattgg catcgtgact      360

atggactggc tggtgaggaa tgtcacctac aggcctcact gccacatctg tttcacccca      420

agggggatca tgcagttcag atttgctcac ccaactcccc gtccatcaga aaaatgttcc      480

aagtggattc tgctggagga ttatcggaag cgggtgcaga acgtcactga gtttgatgac      540

agcttgctga ggaatttcac tctggtgacc cagcacccgg aggtgattta cacaaaccaa      600

aatgttgtct ggtcgaaatt tgaaaccatc ttcttcacca tctctggtct catccattac      660

gctccagtgt tcagagacta tgtcttccgg agcatgcagg agttctacga ggacaacgtg      720

ctctacatgg agatcagagc caggctgctg ccggtgtatg agctcagtgg agagcaccat      780

gacgaagagt ggtcagtgaa gacttatcag gaagtagctc agaagtttgt ggaaactcat      840

cctgagttta ttggaatcaa aatcatttat tcggatcaca gatccaaaga tgtggctgtc      900

atcgcagaat ccatccgaat ggccatgggg ctccgaatca agttccccac ggtggtggca      960

gggtttgacc tggtggggca tgaggacact ggccactcct tgcatgacta caaggaagct     1020

ctgatgatcc ccgccaagga tggcgttaag ctgccttact tcttccacgc cggagaaaca     1080

gactggcagg gtacttccat agacaggaac attctggatg ctctgatgct ggccactacc     1140

agaatcggcc atggatttgc tttgagcaaa caccccgcag tcaggactta ttcctggaaa     1200

aaggacatcc ccatagaagt ctgtcccatc tctaaccagg tgctgaaact ggtgtctgac     1260

ttgaggaacc accctgtagc cactctgatg gccactgggc accccatggt gatcagctct     1320

gatgacccag ctatgtttgg tgccaaaggc ttgtcctatg atttctatga ggtcttcatg     1380

ggcattgggg ggatgaaggc tgatctgagg accctcaaac agctggccat gaactctatc     1440

aagtacagta ccctgttgga gagtgagaaa aatactttca tggaaatatg gaagaagaga     1500

tgggataagt tcatagcaga tgtggctaca aagtga                               1536


<210>  11
<211>  511
<212>  PRT
<213>  Synthetic

<400>  11

Met Leu Val Asp Gly Pro Ser Glu Arg Pro Ala Leu Cys Phe Leu Leu 
1               5                   10                  15      


Leu Ala Val Ala Met Ser Phe Phe Gly Ser Ala Leu Ser Ile Asp Glu 
            20                  25                  30          


Thr Arg Ala His Leu Leu Leu Lys Glu Lys Met Met Arg Leu Gly Gly 
        35                  40                  45              


Arg Leu Val Leu Asn Thr Lys Glu Glu Leu Ala Asn Glu Arg Leu Met 
    50                  55                  60                  


Thr Leu Lys Ile Ala Glu Met Lys Glu Ala Met Arg Thr Leu Ile Phe 
65                  70                  75                  80  


Pro Pro Ser Met His Phe Phe Gln Ala Lys His Leu Ile Glu Arg Ser 
                85                  90                  95      


Gln Val Phe Asn Ile Leu Arg Met Met Pro Lys Gly Ala Ala Leu His 
            100                 105                 110         


Leu His Asp Ile Gly Ile Val Thr Met Asp Trp Leu Val Arg Asn Val 
        115                 120                 125             


Thr Tyr Arg Pro His Cys His Ile Cys Phe Thr Pro Arg Gly Ile Met 
    130                 135                 140                 


Gln Phe Arg Phe Ala His Pro Thr Pro Arg Pro Ser Glu Lys Cys Ser 
145                 150                 155                 160 


Lys Trp Ile Leu Leu Glu Asp Tyr Arg Lys Arg Val Gln Asn Val Thr 
                165                 170                 175     


Glu Phe Asp Asp Ser Leu Leu Arg Asn Phe Thr Leu Val Thr Gln His 
            180                 185                 190         


Pro Glu Val Ile Tyr Thr Asn Gln Asn Val Val Trp Ser Lys Phe Glu 
        195                 200                 205             


Thr Ile Phe Phe Thr Ile Ser Gly Leu Ile His Tyr Ala Pro Val Phe 
    210                 215                 220                 


Arg Asp Tyr Val Phe Arg Ser Met Gln Glu Phe Tyr Glu Asp Asn Val 
225                 230                 235                 240 


Leu Tyr Met Glu Ile Arg Ala Arg Leu Leu Pro Val Tyr Glu Leu Ser 
                245                 250                 255     


Gly Glu His His Asp Glu Glu Trp Ser Val Lys Thr Tyr Gln Glu Val 
            260                 265                 270         


Ala Gln Lys Phe Val Glu Thr His Pro Glu Phe Ile Gly Ile Lys Ile 
        275                 280                 285             


Ile Tyr Ser Asp His Arg Ser Lys Asp Val Ala Val Ile Ala Glu Ser 
    290                 295                 300                 


Ile Arg Met Ala Met Gly Leu Arg Ile Lys Phe Pro Thr Val Val Ala 
305                 310                 315                 320 


Gly Phe Asp Leu Val Gly His Glu Asp Thr Gly His Ser Leu His Asp 
                325                 330                 335     


Tyr Lys Glu Ala Leu Met Ile Pro Ala Lys Asp Gly Val Lys Leu Pro 
            340                 345                 350         


Tyr Phe Phe His Ala Gly Glu Thr Asp Trp Gln Gly Thr Ser Ile Asp 
        355                 360                 365             


Arg Asn Ile Leu Asp Ala Leu Met Leu Asn Thr Thr Arg Ile Gly His 
    370                 375                 380                 


Gly Phe Ala Leu Ser Lys His Pro Ala Val Arg Thr Tyr Ser Trp Lys 
385                 390                 395                 400 


Lys Asp Ile Pro Ile Glu Val Cys Pro Ile Ser Asn Gln Val Leu Lys 
                405                 410                 415     


Leu Val Ser Asp Leu Arg Asn His Pro Val Ala Thr Leu Met Ala Thr 
            420                 425                 430         


Gly His Pro Met Val Ile Ser Ser Glu Asp Pro Ala Met Phe Gly Ala 
        435                 440                 445             


Lys Gly Leu Ser Tyr Asp Phe Tyr Glu Val Phe Met Gly Ile Gly Gly 
    450                 455                 460                 


Met Lys Ala Asp Leu Arg Thr Leu Lys Gln Leu Ala Met Asn Ser Ile 
465                 470                 475                 480 


Lys Tyr Ser Thr Leu Leu Glu Ser Glu Lys Asn Thr Phe Met Glu Ile 
                485                 490                 495     


Trp Lys Lys Arg Trp Asp Lys Phe Ile Ala Asp Val Ala Thr Lys 
            500                 505                 510     


<210>  12
<211>  1536
<212>  DNA
<213>  Synthetic

<400>  12
atgctggtcg acggcccttc agaacggcct gctctgtgct tcctgctgct ggctgtcgca       60

atgagcttct ttggtagtgc cctgtccatc gacgagaccc gggcccacct gctgctgaag      120

gagaagatga tgaggctggg cggcagactg gtgctgaaca ccaaggagga gctggctaat      180

gagcggctga tgacactgaa gatcgccgag atgaaggagg ctatgaggac cctgatcttc      240

cccccttcca tgcacttctt tcaagccaag cacctgattg agagatctca ggtgtttaac      300

atcctgcgga tgatgcccaa gggcgccgct ctgcacctgc acgacatcgg catcgtgacc      360

atggattggc tggtgcggaa tgtgacatac aggcctcact gccacatctg tttcacccca      420

cggggcatca tgcagttcag atttgcccac ccaacacccc ggccttctga gaagtgcagc      480

aagtggatcc tgctggagga ctaccggaag agggtgcaga acgtgaccga gttcgacgat      540

tccctgctgc ggaacttcac cctggtgaca cagcaccctg aagtgatcta caccaaccag      600

aatgtggtgt ggtctaagtt cgagaccatc ttctttacaa tcagcggcct gatccactac      660

gccccagtgt tcagagacta cgtgttccgg agcatgcagg agttttacga ggataacgtg      720

ctgtatatgg agatcagagc tcggctgctg cccgtgtacg agctgtccgg cgagcaccac      780

gatgaggagt ggtctgtgaa gacctaccag gaggtggccc agaagttcgt ggagacacac      840

cccgagttta tcggcatcaa gatcatctat tccgaccacc ggtctaagga tgtggccgtg      900

atcgctgaga gcatccggat ggccatgggc ctgaggatca agttccctac agtggtggct      960

ggctttgacc tggtcggcca cgaggataca ggccactccc tgcacgacta caaggaggcc     1020

ctgatgatcc ccgctaagga tggcgtgaag ctgccttatt tctttcacgc cggcgagacc     1080

gattggcagg gcacaagcat cgacaggaac atcctggatg ctctgatgct gaataccaca     1140

agaatcggcc acggcttcgc cctgagcaag caccctgctg tgcggaccta ctcctggaag     1200

aaggacatcc caatcgaggt gtgccccatc tctaaccaag tgctgaagct ggtgagcgat     1260

ctgcggaatc acccagtggc caccctgatg gctacaggcc acccaatggt catcagctcc     1320

gaagatcccg ccatgtttgg cgctaagggc ctgtcttacg acttctatga ggtgtttatg     1380

ggcatcggcg gcatgaaggc cgatctgcgg accctgaagc agctggctat gaacagcatc     1440

aagtattcca cactgctgga gagcgagaag aatacattca tggaaatctg gaagaaacgg     1500

tgggacaagt tcatcgctga cgtggctact aaatga                               1536


<210>  13
<211>  511
<212>  PRT
<213>  Synthetic

<400>  13

Met Leu Val Asp Gly Pro Ser Glu Arg Pro Ala Leu Cys Phe Leu Leu 
1               5                   10                  15      


Leu Ala Val Ala Met Ser Phe Phe Gly Ser Ala Leu Ser Ile Asp Glu 
            20                  25                  30          


Thr Arg Ala His Leu Leu Leu Lys Glu Lys Met Met Arg Leu Gly Gly 
        35                  40                  45              


Arg Leu Val Leu Asn Thr Lys Glu Glu Leu Ala Asn Glu Arg Leu Met 
    50                  55                  60                  


Thr Leu Lys Ile Ala Glu Met Lys Glu Ala Met Arg Thr Leu Ile Phe 
65                  70                  75                  80  


Pro Pro Ser Met His Phe Phe Gln Ala Lys His Leu Ile Glu Arg Ser 
                85                  90                  95      


Gln Val Phe Asn Ile Leu Arg Met Met Pro Lys Gly Ala Ala Leu His 
            100                 105                 110         


Leu His Asp Ile Gly Ile Val Thr Met Asp Trp Leu Val Arg Asn Val 
        115                 120                 125             


Thr Tyr Arg Pro His Cys His Ile Cys Phe Thr Pro Arg Gly Ile Met 
    130                 135                 140                 


Gln Phe Arg Phe Ala His Pro Thr Pro Arg Pro Ser Glu Lys Cys Ser 
145                 150                 155                 160 


Lys Trp Ile Leu Leu Glu Asp Tyr Arg Lys Arg Val Gln Asn Val Thr 
                165                 170                 175     


Glu Phe Asp Asp Ser Leu Leu Arg Asn Phe Thr Leu Val Thr Gln His 
            180                 185                 190         


Pro Glu Val Ile Tyr Thr Asn Gln Asn Val Val Trp Ser Lys Phe Glu 
        195                 200                 205             


Thr Ile Phe Phe Thr Ile Ser Gly Leu Ile His Tyr Ala Pro Val Phe 
    210                 215                 220                 


Arg Asp Tyr Val Phe Arg Ser Met Gln Glu Phe Tyr Glu Asp Asn Val 
225                 230                 235                 240 


Leu Tyr Met Glu Ile Arg Ala Arg Leu Leu Pro Val Tyr Glu Leu Ser 
                245                 250                 255     


Gly Glu His His Asp Glu Glu Trp Ser Val Lys Thr Tyr Gln Glu Val 
            260                 265                 270         


Ala Gln Lys Phe Val Glu Thr His Pro Glu Phe Ile Gly Ile Lys Ile 
        275                 280                 285             


Ile Tyr Ser Asp His Arg Ser Lys Asp Val Ala Val Ile Ala Glu Ser 
    290                 295                 300                 


Ile Arg Met Ala Met Gly Leu Arg Ile Lys Phe Pro Thr Val Val Ala 
305                 310                 315                 320 


Gly Phe Asp Leu Val Gly His Glu Asp Thr Gly His Ser Leu His Asp 
                325                 330                 335     


Tyr Lys Glu Ala Leu Met Ile Pro Ala Lys Asp Gly Val Lys Leu Pro 
            340                 345                 350         


Tyr Phe Phe His Ala Gly Glu Thr Asp Trp Gln Gly Thr Ser Ile Asp 
        355                 360                 365             


Arg Asn Ile Leu Asp Ala Leu Met Leu Asn Thr Thr Arg Ile Gly His 
    370                 375                 380                 


Gly Phe Ala Leu Ser Lys His Pro Ala Val Arg Thr Tyr Ser Trp Lys 
385                 390                 395                 400 


Lys Asp Ile Pro Ile Glu Val Cys Pro Ile Ser Asn Gln Val Leu Lys 
                405                 410                 415     


Leu Val Ser Asp Leu Arg Asn His Pro Val Ala Thr Leu Met Ala Thr 
            420                 425                 430         


Gly His Pro Met Val Ile Ser Ser Asp Ala Pro Ala Met Phe Gly Ala 
        435                 440                 445             


Lys Gly Leu Ser Tyr Asp Phe Tyr Glu Val Phe Met Gly Ile Gly Gly 
    450                 455                 460                 


Met Lys Ala Asp Leu Arg Thr Leu Lys Gln Leu Ala Met Asn Ser Ile 
465                 470                 475                 480 


Lys Tyr Ser Thr Leu Leu Glu Ser Glu Lys Asn Thr Phe Met Glu Ile 
                485                 490                 495     


Trp Lys Lys Arg Trp Asp Lys Phe Ile Ala Asp Val Ala Thr Lys 
            500                 505                 510     


<210>  14
<211>  1536
<212>  DNA
<213>  Synthetic

<400>  14
atgctggtcg acggcccttc agaacggcct gctctgtgct tcctgctgct ggctgtcgca       60

atgagcttct ttggtagtgc cctgtccatc gacgagaccc gggcccacct gctgctgaag      120

gagaagatga tgaggctggg cggcagactg gtgctgaaca ccaaggagga gctggctaat      180

gagcggctga tgacactgaa gatcgccgag atgaaggagg ctatgaggac cctgatcttc      240

cccccttcca tgcacttctt tcaagccaag cacctgattg agagatctca ggtgtttaac      300

atcctgcgga tgatgcccaa gggcgccgct ctgcacctgc acgacatcgg catcgtgacc      360

atggattggc tggtgcggaa tgtgacatac aggcctcact gccacatctg tttcacccca      420

cggggcatca tgcagttcag atttgcccac ccaacacccc ggccttctga gaagtgcagc      480

aagtggatcc tgctggagga ctaccggaag agggtgcaga acgtgaccga gttcgacgat      540

tccctgctgc ggaacttcac cctggtgaca cagcaccctg aagtgatcta caccaaccag      600

aatgtggtgt ggtctaagtt cgagaccatc ttctttacaa tcagcggcct gatccactac      660

gccccagtgt tcagagacta cgtgttccgg agcatgcagg agttttacga ggataacgtg      720

ctgtatatgg agatcagagc tcggctgctg cccgtgtacg agctgtccgg cgagcaccac      780

gatgaggagt ggtctgtgaa gacctaccag gaggtggccc agaagttcgt ggagacacac      840

cccgagttta tcggcatcaa gatcatctat tccgaccacc ggtctaagga tgtggccgtg      900

atcgctgaga gcatccggat ggccatgggc ctgaggatca agttccctac agtggtggct      960

ggctttgacc tggtcggcca cgaggataca ggccactccc tgcacgacta caaggaggcc     1020

ctgatgatcc ccgctaagga tggcgtgaag ctgccttatt tctttcacgc cggcgagacc     1080

gattggcagg gcacaagcat cgacaggaac atcctggatg ctctgatgct gaataccaca     1140

agaatcggcc acggcttcgc cctgagcaag caccctgctg tgcggaccta ctcctggaag     1200

aaggacatcc caatcgaggt gtgccccatc tctaaccaag tgctgaagct ggtgagcgat     1260

ctgcggaatc acccagtggc caccctgatg gctacaggcc acccaatggt catcagctcc     1320

gacgctcccg ccatgtttgg cgctaagggc ctgtcttacg acttctatga ggtgtttatg     1380

ggcatcggcg gcatgaaggc cgatctgcgg accctgaagc agctggctat gaacagcatc     1440

aagtattcca cactgctgga gagcgagaag aatacattca tggaaatctg gaagaaacgg     1500

tgggacaagt tcatcgctga cgtggctact aaatga                               1536


<210>  15
<211>  511
<212>  PRT
<213>  Synthetic

<400>  15

Met Leu Val Asp Gly Pro Ser Glu Arg Pro Ala Leu Cys Phe Leu Leu 
1               5                   10                  15      


Leu Ala Val Ala Met Ser Phe Phe Gly Ser Ala Leu Ser Ile Asp Glu 
            20                  25                  30          


Thr Arg Ala His Leu Leu Leu Lys Glu Lys Met Met Arg Leu Gly Gly 
        35                  40                  45              


Arg Leu Val Leu Asn Thr Lys Glu Glu Leu Ala Asn Glu Arg Leu Met 
    50                  55                  60                  


Thr Leu Lys Ile Ala Glu Met Lys Glu Ala Met Arg Thr Leu Ile Phe 
65                  70                  75                  80  


Pro Pro Ser Met His Phe Phe Gln Ala Lys His Leu Ile Glu Arg Ser 
                85                  90                  95      


Gln Val Phe Asn Ile Leu Arg Met Met Pro Lys Gly Ala Ala Leu His 
            100                 105                 110         


Leu His Asp Ile Gly Ile Val Thr Met Asp Trp Leu Val Arg Asn Val 
        115                 120                 125             


Thr Tyr Arg Pro His Cys His Ile Cys Phe Thr Pro Arg Gly Ile Met 
    130                 135                 140                 


Gln Phe Arg Phe Ala His Pro Thr Pro Arg Pro Ser Glu Lys Cys Ser 
145                 150                 155                 160 


Lys Trp Ile Leu Leu Glu Asp Tyr Arg Lys Arg Val Gln Asn Val Thr 
                165                 170                 175     


Glu Phe Asp Asp Ser Leu Leu Arg Asn Phe Thr Leu Val Thr Gln His 
            180                 185                 190         


Pro Glu Val Ile Tyr Thr Asn Gln Asn Val Val Trp Ser Lys Phe Glu 
        195                 200                 205             


Thr Ile Phe Phe Thr Ile Ser Gly Leu Ile His Tyr Ala Pro Val Phe 
    210                 215                 220                 


Arg Asp Tyr Val Phe Arg Ser Met Gln Glu Phe Tyr Glu Asp Asn Val 
225                 230                 235                 240 


Leu Tyr Met Glu Ile Arg Ala Arg Leu Leu Pro Val Tyr Glu Leu Ser 
                245                 250                 255     


Gly Glu His His Asp Glu Glu Trp Ser Val Lys Thr Tyr Gln Glu Val 
            260                 265                 270         


Ala Gln Lys Phe Val Glu Thr His Pro Glu Phe Ile Gly Ile Lys Ile 
        275                 280                 285             


Ile Tyr Ser Asp His Arg Ser Lys Asp Val Ala Val Ile Ala Glu Ser 
    290                 295                 300                 


Ile Arg Met Ala Met Gly Leu Arg Ile Lys Phe Pro Thr Val Val Ala 
305                 310                 315                 320 


Gly Phe Asp Leu Val Gly His Glu Asp Thr Gly His Ser Leu His Asp 
                325                 330                 335     


Tyr Lys Glu Ala Leu Met Ile Pro Ala Lys Asp Gly Val Lys Leu Pro 
            340                 345                 350         


Tyr Phe Phe His Ala Gly Glu Thr Asp Gly Gln Gly Thr Ser Ile Asp 
        355                 360                 365             


Arg Asn Ile Leu Asp Ala Leu Met Leu Asn Thr Thr Arg Ile Gly His 
    370                 375                 380                 


Gly Phe Ala Leu Ser Lys His Pro Ala Val Arg Thr Tyr Ser Trp Lys 
385                 390                 395                 400 


Lys Asp Ile Pro Ile Glu Val Cys Pro Ile Ser Asn Gln Val Leu Lys 
                405                 410                 415     


Leu Val Ser Asp Leu Arg Asn His Pro Val Ala Thr Leu Met Ala Thr 
            420                 425                 430         


Gly His Pro Met Val Ile Ser Ser Asp Asp Pro Ala Met Phe Gly Ala 
        435                 440                 445             


Lys Gly Leu Ser Tyr Asp Phe Tyr Glu Val Phe Met Gly Ile Gly Gly 
    450                 455                 460                 


Met Lys Ala Asp Leu Arg Thr Leu Lys Gln Leu Ala Met Asn Ser Ile 
465                 470                 475                 480 


Lys Tyr Ser Thr Leu Leu Glu Ser Glu Lys Asn Thr Phe Met Glu Ile 
                485                 490                 495     


Trp Lys Lys Arg Trp Asp Lys Phe Ile Ala Asp Val Ala Thr Lys 
            500                 505                 510     


<210>  16
<211>  1536
<212>  DNA
<213>  Synthetic

<400>  16
atgctggtcg acggcccttc agaacggcct gctctgtgct tcctgctgct ggctgtcgca       60

atgagcttct ttggtagtgc cctgtccatc gacgagaccc gggcccacct gctgctgaag      120

gagaagatga tgaggctggg cggcagactg gtgctgaaca ccaaggagga gctggctaat      180

gagcggctga tgacactgaa gatcgccgag atgaaggagg ctatgaggac cctgatcttc      240

cccccttcca tgcacttctt tcaagccaag cacctgattg agagatctca ggtgtttaac      300

atcctgcgga tgatgcccaa gggcgccgct ctgcacctgc acgacatcgg catcgtgacc      360

atggattggc tggtgcggaa tgtgacatac aggcctcact gccacatctg tttcacccca      420

cggggcatca tgcagttcag atttgcccac ccaacacccc ggccttctga gaagtgcagc      480

aagtggatcc tgctggagga ctaccggaag agggtgcaga acgtgaccga gttcgacgat      540

tccctgctgc ggaacttcac cctggtgaca cagcaccctg aagtgatcta caccaaccag      600

aatgtggtgt ggtctaagtt cgagaccatc ttctttacaa tcagcggcct gatccactac      660

gccccagtgt tcagagacta cgtgttccgg agcatgcagg agttttacga ggataacgtg      720

ctgtatatgg agatcagagc tcggctgctg cccgtgtacg agctgtccgg cgagcaccac      780

gatgaggagt ggtctgtgaa gacctaccag gaggtggccc agaagttcgt ggagacacac      840

cccgagttta tcggcatcaa gatcatctat tccgaccacc ggtctaagga tgtggccgtg      900

atcgctgaga gcatccggat ggccatgggc ctgaggatca agttccctac agtggtggct      960

ggctttgacc tggtcggcca cgaggataca ggccactccc tgcacgacta caaggaggcc     1020

ctgatgatcc ccgctaagga tggcgtgaag ctgccttatt tctttcacgc cggcgagacc     1080

gatggccagg gcacaagcat cgacaggaac atcctggatg ctctgatgct gaataccaca     1140

agaatcggcc acggcttcgc cctgagcaag caccctgctg tgcggaccta ctcctggaag     1200

aaggacatcc caatcgaggt gtgccccatc tctaaccaag tgctgaagct ggtgagcgat     1260

ctgcggaatc acccagtggc caccctgatg gctacaggcc acccaatggt catcagctcc     1320

gacgatcccg ccatgtttgg cgctaagggc ctgtcttacg acttctatga ggtgtttatg     1380

ggcatcggcg gcatgaaggc cgatctgcgg accctgaagc agctggctat gaacagcatc     1440

aagtattcca cactgctgga gagcgagaag aatacattca tggaaatctg gaagaaacgg     1500

tgggacaagt tcatcgctga cgtggctact aaatga                               1536


<210>  17
<211>  511
<212>  PRT
<213>  Synthetic

<400>  17

Met Leu Val Asp Gly Pro Ser Glu Arg Pro Ala Leu Cys Phe Leu Leu 
1               5                   10                  15      


Leu Ala Val Ala Met Ser Phe Phe Gly Ser Ala Leu Ser Ile Asp Glu 
            20                  25                  30          


Thr Arg Ala His Leu Leu Leu Lys Glu Lys Met Met Arg Leu Gly Gly 
        35                  40                  45              


Arg Leu Val Leu Asn Thr Lys Glu Glu Leu Ala Asn Glu Arg Leu Met 
    50                  55                  60                  


Thr Leu Lys Ile Ala Glu Met Lys Glu Ala Met Arg Thr Leu Ile Phe 
65                  70                  75                  80  


Pro Pro Ser Met His Phe Phe Gln Ala Lys His Leu Ile Glu Arg Ser 
                85                  90                  95      


Gln Val Phe Asn Ile Leu Arg Met Met Pro Lys Gly Ala Ala Leu Gln 
            100                 105                 110         


Leu His Asp Ile Gly Ile Val Thr Met Asp Trp Leu Val Arg Asn Val 
        115                 120                 125             


Thr Tyr Arg Pro His Cys His Ile Cys Phe Thr Pro Arg Gly Ile Met 
    130                 135                 140                 


Gln Phe Arg Phe Ala His Pro Thr Pro Arg Pro Ser Glu Lys Cys Ser 
145                 150                 155                 160 


Lys Trp Ile Leu Leu Glu Asp Tyr Arg Lys Arg Val Gln Asn Val Thr 
                165                 170                 175     


Glu Phe Asp Asp Ser Leu Leu Arg Asn Phe Thr Leu Val Thr Gln His 
            180                 185                 190         


Pro Glu Val Ile Tyr Thr Asn Gln Asn Val Val Trp Ser Lys Phe Glu 
        195                 200                 205             


Thr Ile Phe Phe Thr Ile Ser Gly Leu Ile His Tyr Ala Pro Val Phe 
    210                 215                 220                 


Arg Asp Tyr Val Phe Arg Ser Met Gln Glu Phe Tyr Glu Asp Asn Val 
225                 230                 235                 240 


Leu Tyr Met Glu Ile Arg Ala Arg Leu Leu Pro Val Tyr Glu Leu Ser 
                245                 250                 255     


Gly Glu His His Asp Glu Glu Trp Ser Val Lys Thr Tyr Gln Glu Val 
            260                 265                 270         


Ala Gln Lys Phe Val Glu Thr His Pro Glu Phe Ile Gly Ile Lys Ile 
        275                 280                 285             


Ile Tyr Ser Asp His Arg Ser Lys Asp Val Ala Val Ile Ala Glu Ser 
    290                 295                 300                 


Ile Arg Met Ala Met Gly Leu Arg Ile Lys Phe Pro Thr Val Val Ala 
305                 310                 315                 320 


Gly Phe Asp Leu Val Gly His Glu Asp Thr Gly His Ser Leu His Asp 
                325                 330                 335     


Tyr Lys Glu Ala Leu Met Ile Pro Ala Lys Asp Gly Val Lys Leu Pro 
            340                 345                 350         


Tyr Phe Phe His Ala Gly Glu Thr Asp Trp Gln Gly Thr Ser Ile Asp 
        355                 360                 365             


Arg Asn Ile Leu Asp Ala Leu Met Leu Asn Thr Thr Arg Ile Gly His 
    370                 375                 380                 


Gly Phe Ala Leu Ser Lys His Pro Ala Val Arg Thr Tyr Ser Trp Lys 
385                 390                 395                 400 


Lys Asp Ile Pro Ile Glu Val Cys Pro Ile Ser Asn Gln Val Leu Lys 
                405                 410                 415     


Leu Val Ser Asp Leu Arg Asn His Pro Val Ala Thr Leu Met Ala Thr 
            420                 425                 430         


Gly His Pro Met Val Ile Ser Ser Asp Asp Pro Ala Met Phe Gly Ala 
        435                 440                 445             


Lys Gly Leu Ser Tyr Asp Phe Tyr Glu Val Phe Met Gly Ile Gly Gly 
    450                 455                 460                 


Met Lys Ala Asp Leu Arg Thr Leu Lys Gln Leu Ala Met Asn Ser Ile 
465                 470                 475                 480 


Lys Tyr Ser Thr Leu Leu Glu Ser Glu Lys Asn Thr Phe Met Glu Ile 
                485                 490                 495     


Trp Lys Lys Arg Trp Asp Lys Phe Ile Ala Asp Val Ala Thr Lys 
            500                 505                 510     


<210>  18
<211>  1536
<212>  DNA
<213>  Synthetic

<400>  18
atgctggtcg acggcccttc agaacggcct gctctgtgct tcctgctgct ggctgtcgca       60

atgagcttct ttggtagtgc cctgtccatc gacgagaccc gggcccacct gctgctgaag      120

gagaagatga tgaggctggg cggcagactg gtgctgaaca ccaaggagga gctggctaat      180

gagcggctga tgacactgaa gatcgccgag atgaaggagg ctatgaggac cctgatcttc      240

cccccttcca tgcacttctt tcaagccaag cacctgattg agagatctca ggtgtttaac      300

atcctgcgga tgatgcccaa gggcgccgct ctgcaactgc acgacatcgg catcgtgacc      360

atggattggc tggtgcggaa tgtgacatac aggcctcact gccacatctg tttcacccca      420

cggggcatca tgcagttcag atttgcccac ccaacacccc ggccttctga gaagtgcagc      480

aagtggatcc tgctggagga ctaccggaag agggtgcaga acgtgaccga gttcgacgat      540

tccctgctgc ggaacttcac cctggtgaca cagcaccctg aagtgatcta caccaaccag      600

aatgtggtgt ggtctaagtt cgagaccatc ttctttacaa tcagcggcct gatccactac      660

gccccagtgt tcagagacta cgtgttccgg agcatgcagg agttttacga ggataacgtg      720

ctgtatatgg agatcagagc tcggctgctg cccgtgtacg agctgtccgg cgagcaccac      780

gatgaggagt ggtctgtgaa gacctaccag gaggtggccc agaagttcgt ggagacacac      840

cccgagttta tcggcatcaa gatcatctat tccgaccacc ggtctaagga tgtggccgtg      900

atcgctgaga gcatccggat ggccatgggc ctgaggatca agttccctac agtggtggct      960

ggctttgacc tggtcggcca cgaggataca ggccactccc tgcacgacta caaggaggcc     1020

ctgatgatcc ccgctaagga tggcgtgaag ctgccttatt tctttcacgc cggcgagacc     1080

gattggcagg gcacaagcat cgacaggaac atcctggatg ctctgatgct gaataccaca     1140

agaatcggcc acggcttcgc cctgagcaag caccctgctg tgcggaccta ctcctggaag     1200

aaggacatcc caatcgaggt gtgccccatc tctaaccaag tgctgaagct ggtgagcgat     1260

ctgcggaatc acccagtggc caccctgatg gctacaggcc acccaatggt catcagctcc     1320

gacgatcccg ccatgtttgg cgctaagggc ctgtcttacg acttctatga ggtgtttatg     1380

ggcatcggcg gcatgaaggc cgatctgcgg accctgaagc agctggctat gaacagcatc     1440

aagtattcca cactgctgga gagcgagaag aatacattca tggaaatctg gaagaaacgg     1500

tgggacaagt tcatcgctga cgtggctact aaatga                               1536


<210>  19
<211>  743
<212>  PRT
<213>  Synthetic

<400>  19

Met Leu Val Asp Gly Pro Ser Glu Arg Pro Ala Leu Cys Phe Leu Leu 
1               5                   10                  15      


Leu Ala Val Ala Met Ser Phe Phe Gly Ser Ala Leu Ser Ile Asp Glu 
            20                  25                  30          


Thr Arg Ala His Leu Leu Leu Lys Glu Lys Met Met Arg Leu Gly Gly 
        35                  40                  45              


Arg Leu Val Leu Asn Thr Lys Glu Glu Leu Ala Asn Glu Arg Leu Met 
    50                  55                  60                  


Thr Leu Lys Ile Ala Glu Met Lys Glu Ala Met Arg Thr Leu Ile Phe 
65                  70                  75                  80  


Pro Pro Ser Met His Phe Phe Gln Ala Lys His Leu Ile Glu Arg Ser 
                85                  90                  95      


Gln Val Phe Asn Ile Leu Arg Met Met Pro Lys Gly Ala Ala Leu His 
            100                 105                 110         


Leu His Asp Ile Gly Ile Val Thr Met Asp Trp Leu Val Arg Asn Val 
        115                 120                 125             


Thr Tyr Arg Pro His Cys His Ile Cys Phe Thr Pro Arg Gly Ile Met 
    130                 135                 140                 


Gln Phe Arg Phe Ala His Pro Thr Pro Arg Pro Ser Glu Lys Cys Ser 
145                 150                 155                 160 


Lys Trp Ile Leu Leu Glu Asp Tyr Arg Lys Arg Val Gln Asn Val Thr 
                165                 170                 175     


Glu Phe Asp Asp Ser Leu Leu Arg Asn Phe Thr Leu Val Thr Gln His 
            180                 185                 190         


Pro Glu Val Ile Tyr Thr Asn Gln Asn Val Val Trp Ser Lys Phe Glu 
        195                 200                 205             


Thr Ile Phe Phe Thr Ile Ser Gly Leu Ile His Tyr Ala Pro Val Phe 
    210                 215                 220                 


Arg Asp Tyr Val Phe Arg Ser Met Gln Glu Phe Tyr Glu Asp Asn Val 
225                 230                 235                 240 


Leu Tyr Met Glu Ile Arg Ala Arg Leu Leu Pro Val Tyr Glu Leu Ser 
                245                 250                 255     


Gly Glu His His Asp Glu Glu Trp Ser Val Lys Thr Tyr Gln Glu Val 
            260                 265                 270         


Ala Gln Lys Phe Val Glu Thr His Pro Glu Phe Ile Gly Ile Lys Ile 
        275                 280                 285             


Ile Tyr Ser Asp His Arg Ser Lys Asp Val Ala Val Ile Ala Glu Ser 
    290                 295                 300                 


Ile Arg Met Ala Met Gly Leu Arg Ile Lys Phe Pro Thr Val Val Ala 
305                 310                 315                 320 


Gly Phe Asp Leu Val Gly His Glu Asp Thr Gly His Ser Leu His Asp 
                325                 330                 335     


Tyr Lys Glu Ala Leu Met Ile Pro Ala Lys Asp Gly Val Lys Leu Pro 
            340                 345                 350         


Tyr Phe Phe His Ala Gly Glu Thr Asp Trp Gln Gly Thr Ser Ile Asp 
        355                 360                 365             


Arg Asn Ile Leu Asp Ala Leu Met Leu Asn Thr Thr Arg Ile Gly His 
    370                 375                 380                 


Gly Phe Ala Leu Ser Lys His Pro Ala Val Arg Thr Tyr Ser Trp Lys 
385                 390                 395                 400 


Lys Asp Ile Pro Ile Glu Val Cys Pro Ile Ser Asn Gln Val Leu Lys 
                405                 410                 415     


Leu Val Ser Asp Leu Arg Asn His Pro Val Ala Thr Leu Met Ala Thr 
            420                 425                 430         


Gly His Pro Met Val Ile Ser Ser Asp Asp Pro Ala Met Phe Gly Ala 
        435                 440                 445             


Lys Gly Leu Ser Tyr Asp Phe Tyr Glu Val Phe Met Gly Ile Gly Gly 
    450                 455                 460                 


Met Lys Ala Asp Leu Arg Thr Leu Lys Gln Leu Ala Met Asn Ser Ile 
465                 470                 475                 480 


Lys Tyr Ser Thr Leu Leu Glu Ser Glu Lys Asn Thr Phe Met Glu Ile 
                485                 490                 495     


Trp Lys Lys Arg Trp Asp Lys Phe Ile Ala Asp Val Ala Thr Lys Glu 
            500                 505                 510         


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        515                 520                 525             


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    530                 535                 540                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
545                 550                 555                 560 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                565                 570                 575     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            580                 585                 590         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        595                 600                 605             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    610                 615                 620                 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
625                 630                 635                 640 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
                645                 650                 655     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            660                 665                 670         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        675                 680                 685             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    690                 695                 700                 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
705                 710                 715                 720 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                725                 730                 735     


Leu Ser Leu Ser Pro Gly Lys 
            740             


<210>  20
<211>  2232
<212>  DNA
<213>  Synthetic

<400>  20
atgttggtgg atggcccatc tgagcggcca gccctgtgct tcttgctgtt ggctgtggca       60

atgtctttct tcggctctgc tctatccata gatgaaacac gggcgcatct gttgttgaaa      120

gaaaagatga tgcggctggg ggggcggctg gtgctgaaca ccaaggagga gctggccaat      180

gagaggctca tgacgctcaa aatcgctgag atgaaggagg ccatgaggac cctgatattc      240

ccacccagca tgcacttttt ccaggccaag catctcattg agagaagtca agtgtttaat      300

attctaagga tgatgccaaa aggggctgcc ttgcacctcc atgacattgg catcgtgact      360

atggactggc tggtgaggaa tgtcacctac aggcctcact gccacatctg tttcacccca      420

agggggatca tgcagttcag atttgctcac ccaactcccc gtccatcaga aaaatgttcc      480

aagtggattc tgctggagga ttatcggaag cgggtgcaga acgtcactga gtttgatgac      540

agcttgctga ggaatttcac tctggtgacc cagcacccgg aggtgattta cacaaaccaa      600

aatgttgtct ggtcgaaatt tgaaaccatc ttcttcacca tctctggtct catccattac      660

gctccagtgt tcagagacta tgtcttccgg agcatgcagg agttctacga ggacaacgtg      720

ctctacatgg agatcagagc caggctgctg ccggtgtatg agctcagtgg agagcaccat      780

gacgaagagt ggtcagtgaa gacttatcag gaagtagctc agaagtttgt ggaaactcat      840

cctgagttta ttggaatcaa aatcatttat tcggatcaca gatccaaaga tgtggctgtc      900

atcgcagaat ccatccgaat ggccatgggg ctccgaatca agttccccac ggtggtggca      960

gggtttgacc tggtggggca tgaggacact ggccactcct tgcatgacta caaggaagct     1020

ctgatgatcc ccgccaagga tggcgttaag ctgccttact tcttccacgc cggagaaaca     1080

gactggcagg gtacttccat agacaggaac attctggatg ctctgatgct gaacactacc     1140

agaatcggcc atggatttgc tttgagcaaa caccccgcag tcaggactta ttcctggaaa     1200

aaggacatcc ccatagaagt ctgtcccatc tctaaccagg tgctgaaact ggtgtctgac     1260

ttgaggaacc accctgtagc cactctgatg gccactgggc accccatggt gatcagctct     1320

gatgacccag ctatgtttgg tgccaaaggc ttgtcctatg atttctatga ggtcttcatg     1380

ggcattgggg ggatgaaggc tgatctgagg accctcaaac agctggccat gaactctatc     1440

aagtacagta ccctgttgga gagtgagaaa aatactttca tggaaatatg gaagaagaga     1500

tgggataagt tcatagcaga tgtggctaca aaggagccca aatcttgtga caaaactcac     1560

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc     1620

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg     1680

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     1740

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     1800

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc     1860

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1920

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc     1980

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     2040

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     2100

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     2160

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtcc     2220

ccgggtaaat ga                                                         2232


<210>  21
<211>  743
<212>  PRT
<213>  Synthetic

<400>  21

Met Leu Val Asp Gly Pro Ser Glu Arg Pro Ala Leu Cys Phe Leu Leu 
1               5                   10                  15      


Leu Ala Val Ala Met Ser Phe Phe Gly Ser Ala Leu Ser Ile Asp Glu 
            20                  25                  30          


Thr Arg Ala His Leu Leu Leu Lys Glu Lys Met Met Arg Leu Gly Gly 
        35                  40                  45              


Arg Leu Val Leu Asn Thr Lys Glu Glu Leu Ala Asn Glu Arg Leu Met 
    50                  55                  60                  


Thr Leu Lys Ile Ala Glu Met Lys Glu Ala Met Arg Thr Leu Ile Phe 
65                  70                  75                  80  


Pro Pro Ser Met His Phe Phe Gln Ala Lys His Leu Ile Glu Arg Ser 
                85                  90                  95      


Gln Val Phe Asn Ile Leu Arg Met Met Pro Lys Gly Ala Ala Leu His 
            100                 105                 110         


Leu His Asp Ile Gly Ile Val Thr Met Asp Trp Leu Val Arg Asn Val 
        115                 120                 125             


Thr Tyr Arg Pro His Cys His Ile Cys Phe Thr Pro Arg Gly Ile Met 
    130                 135                 140                 


Gln Phe Arg Phe Ala His Pro Thr Pro Arg Pro Ser Glu Lys Cys Ser 
145                 150                 155                 160 


Lys Trp Ile Leu Leu Glu Asp Tyr Arg Lys Arg Val Gln Asn Val Thr 
                165                 170                 175     


Glu Phe Asp Asp Ser Leu Leu Arg Asn Phe Thr Leu Val Thr Gln His 
            180                 185                 190         


Pro Glu Val Ile Tyr Thr Asn Gln Asn Val Val Trp Ser Lys Phe Glu 
        195                 200                 205             


Thr Ile Phe Phe Thr Ile Ser Gly Leu Ile His Tyr Ala Pro Val Phe 
    210                 215                 220                 


Arg Asp Tyr Val Phe Arg Ser Met Gln Glu Phe Tyr Glu Asp Asn Val 
225                 230                 235                 240 


Leu Tyr Met Glu Ile Arg Ala Arg Leu Leu Pro Val Tyr Glu Leu Ser 
                245                 250                 255     


Gly Glu His His Asp Glu Glu Trp Ser Val Lys Thr Tyr Gln Glu Val 
            260                 265                 270         


Ala Gln Lys Phe Val Glu Thr His Pro Glu Phe Ile Gly Ile Lys Ile 
        275                 280                 285             


Ile Tyr Ser Asp His Arg Ser Lys Asp Val Ala Val Ile Ala Glu Ser 
    290                 295                 300                 


Ile Arg Met Ala Met Gly Leu Arg Ile Lys Phe Pro Thr Val Val Ala 
305                 310                 315                 320 


Gly Phe Asp Leu Val Gly His Glu Asp Thr Gly His Ser Leu His Asp 
                325                 330                 335     


Tyr Lys Glu Ala Leu Met Ile Pro Ala Lys Asp Gly Val Lys Leu Pro 
            340                 345                 350         


Tyr Phe Phe His Ala Gly Glu Thr Asp Trp Gln Gly Thr Ser Ile Asp 
        355                 360                 365             


Arg Asn Ile Leu Asp Ala Leu Met Leu Asn Thr Thr Arg Ile Gly His 
    370                 375                 380                 


Gly Phe Ala Leu Ser Lys His Pro Ala Val Arg Thr Tyr Ser Trp Lys 
385                 390                 395                 400 


Lys Asp Ile Pro Ile Glu Val Cys Pro Ile Ser Asn Gln Val Leu Lys 
                405                 410                 415     


Leu Val Ser Asp Leu Arg Asn His Pro Val Ala Thr Leu Met Ala Thr 
            420                 425                 430         


Gly His Pro Met Val Ile Ser Ser Asp Asp Pro Ala Met Phe Gly Ala 
        435                 440                 445             


Lys Gly Leu Ser Tyr Asp Phe Tyr Glu Val Phe Met Gly Ile Gly Gly 
    450                 455                 460                 


Met Lys Ala Asp Leu Arg Thr Leu Lys Gln Leu Ala Met Asn Ser Ile 
465                 470                 475                 480 


Lys Tyr Ser Thr Leu Leu Glu Ser Glu Lys Asn Thr Phe Met Glu Ile 
                485                 490                 495     


Trp Lys Lys Arg Trp Asp Lys Phe Ile Ala Asp Val Ala Thr Lys Glu 
            500                 505                 510         


Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        515                 520                 525             


Glu Ala Ala Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    530                 535                 540                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
545                 550                 555                 560 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                565                 570                 575     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            580                 585                 590         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        595                 600                 605             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    610                 615                 620                 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
625                 630                 635                 640 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
                645                 650                 655     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            660                 665                 670         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        675                 680                 685             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    690                 695                 700                 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
705                 710                 715                 720 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                725                 730                 735     


Leu Ser Leu Ser Pro Gly Lys 
            740             


<210>  22
<211>  2232
<212>  DNA
<213>  Synthetic

<400>  22
atgttggtgg atggcccatc tgagcggcca gccctgtgct tcttgctgtt ggctgtggca       60

atgtctttct tcggctctgc tctatccata gatgaaacac gggcgcatct gttgttgaaa      120

gaaaagatga tgcggctggg ggggcggctg gtgctgaaca ccaaggagga gctggccaat      180

gagaggctca tgacgctcaa aatcgctgag atgaaggagg ccatgaggac cctgatattc      240

ccacccagca tgcacttttt ccaggccaag catctcattg agagaagtca agtgtttaat      300

attctaagga tgatgccaaa aggggctgcc ttgcacctcc atgacattgg catcgtgact      360

atggactggc tggtgaggaa tgtcacctac aggcctcact gccacatctg tttcacccca      420

agggggatca tgcagttcag atttgctcac ccaactcccc gtccatcaga aaaatgttcc      480

aagtggattc tgctggagga ttatcggaag cgggtgcaga acgtcactga gtttgatgac      540

agcttgctga ggaatttcac tctggtgacc cagcacccgg aggtgattta cacaaaccaa      600

aatgttgtct ggtcgaaatt tgaaaccatc ttcttcacca tctctggtct catccattac      660

gctccagtgt tcagagacta tgtcttccgg agcatgcagg agttctacga ggacaacgtg      720

ctctacatgg agatcagagc caggctgctg ccggtgtatg agctcagtgg agagcaccat      780

gacgaagagt ggtcagtgaa gacttatcag gaagtagctc agaagtttgt ggaaactcat      840

cctgagttta ttggaatcaa aatcatttat tcggatcaca gatccaaaga tgtggctgtc      900

atcgcagaat ccatccgaat ggccatgggg ctccgaatca agttccccac ggtggtggca      960

gggtttgacc tggtggggca tgaggacact ggccactcct tgcatgacta caaggaagct     1020

ctgatgatcc ccgccaagga tggcgttaag ctgccttact tcttccacgc cggagaaaca     1080

gactggcagg gtacttccat agacaggaac attctggatg ctctgatgct gaacactacc     1140

agaatcggcc atggatttgc tttgagcaaa caccccgcag tcaggactta ttcctggaaa     1200

aaggacatcc ccatagaagt ctgtcccatc tctaaccagg tgctgaaact ggtgtctgac     1260

ttgaggaacc accctgtagc cactctgatg gccactgggc accccatggt gatcagctct     1320

gatgacccag ctatgtttgg tgccaaaggc ttgtcctatg atttctatga ggtcttcatg     1380

ggcattgggg ggatgaaggc tgatctgagg accctcaaac agctggccat gaactctatc     1440

aagtacagta ccctgttgga gagtgagaaa aatactttca tggaaatatg gaagaagaga     1500

tgggataagt tcatagcaga tgtggctaca aaggagccca aatcctccga caagacacac     1560

acatgtcctc cctgtcccgc tcctgaagct gccggaggat ccagcgtgtt tctcttccct     1620

cctaagccca aggacaccct catgatcagc agaacccccg aagtcacctg cgtcgtggtc     1680

gacgtctccc acgaggaccc cgaagtgaag ttcaactggt acgtggacgg agtcgaggtc     1740

cacaacgcca agaccaagcc cagggaggag cagtacaaca gcacatacag ggtggtgagc     1800

gtcctcaccg tcctccatca ggactggctg aacggcaagg agtacaaatg caaggtgagc     1860

aataaggccc tccctgcccc catcgaaaag accatctcca aagccaaggg ccaacctaga     1920

gaaccccagg tctataccct ccctccctcc agagacgagc tcacaaagaa ccaggtcagc     1980

ctgacctgtc tggtgaaggg attctaccct tccgacattg ccgtcgagtg ggagtccaat     2040

ggccagcccg agaacaatta caagaccaca ccccctgtcc tcgactccga cggctccttc     2100

ttcctgtact ccaagctgac cgtcgacaag tccaggtggc aacagggcaa cgtcttcagc     2160

tgctccgtca tgcatgaggc cctccacaac cactacacac agaagtccct ctccctgagc     2220

cccggcaagt ga                                                         2232


<210>  23
<211>  567
<212>  PRT
<213>  Synthetic

<400>  23

Met Leu Val Asp Gly Pro Ser Glu Arg Pro Ala Leu Cys Phe Leu Leu 
1               5                   10                  15      


Leu Ala Val Ala Met Ser Phe Phe Gly Ser Ala Leu Ser Ile Asp Glu 
            20                  25                  30          


Thr Arg Ala His Leu Leu Leu Lys Glu Lys Met Met Arg Leu Gly Gly 
        35                  40                  45              


Arg Leu Val Leu Asn Thr Lys Glu Glu Leu Ala Asn Glu Arg Leu Met 
    50                  55                  60                  


Thr Leu Lys Ile Ala Glu Met Lys Glu Ala Met Arg Thr Leu Ile Phe 
65                  70                  75                  80  


Pro Pro Ser Met His Phe Phe Gln Ala Lys His Leu Ile Glu Arg Ser 
                85                  90                  95      


Gln Val Phe Asn Ile Leu Arg Met Met Pro Lys Gly Ala Ala Leu His 
            100                 105                 110         


Leu His Asp Ile Gly Ile Val Thr Met Asp Trp Leu Val Arg Asn Val 
        115                 120                 125             


Thr Tyr Arg Pro His Cys His Ile Cys Phe Thr Pro Arg Gly Ile Met 
    130                 135                 140                 


Gln Phe Arg Phe Ala His Pro Thr Pro Arg Pro Ser Glu Lys Cys Ser 
145                 150                 155                 160 


Lys Trp Ile Leu Leu Glu Asp Tyr Arg Lys Arg Val Gln Asn Val Thr 
                165                 170                 175     


Glu Phe Asp Asp Ser Leu Leu Arg Asn Phe Thr Leu Val Thr Gln His 
            180                 185                 190         


Pro Glu Val Ile Tyr Thr Asn Gln Asn Val Val Trp Ser Lys Phe Glu 
        195                 200                 205             


Thr Ile Phe Phe Thr Ile Ser Gly Leu Ile His Tyr Ala Pro Val Phe 
    210                 215                 220                 


Arg Asp Tyr Val Phe Arg Ser Met Gln Glu Phe Tyr Glu Asp Asn Val 
225                 230                 235                 240 


Leu Tyr Met Glu Ile Arg Ala Arg Leu Leu Pro Val Tyr Glu Leu Ser 
                245                 250                 255     


Gly Glu His His Asp Glu Glu Trp Ser Val Lys Thr Tyr Gln Glu Val 
            260                 265                 270         


Ala Gln Lys Phe Val Glu Thr His Pro Glu Phe Ile Gly Ile Lys Ile 
        275                 280                 285             


Ile Tyr Ser Asp His Arg Ser Lys Asp Val Ala Val Ile Ala Glu Ser 
    290                 295                 300                 


Ile Arg Met Ala Met Gly Leu Arg Ile Lys Phe Pro Thr Val Val Ala 
305                 310                 315                 320 


Gly Phe Asp Leu Val Gly His Glu Asp Thr Gly His Ser Leu His Asp 
                325                 330                 335     


Tyr Lys Glu Ala Leu Met Ile Pro Ala Lys Asp Gly Val Lys Leu Pro 
            340                 345                 350         


Tyr Phe Phe His Ala Gly Glu Thr Asp Trp Gln Gly Thr Ser Ile Asp 
        355                 360                 365             


Arg Asn Ile Leu Asp Ala Leu Met Leu Asn Thr Thr Arg Ile Gly His 
    370                 375                 380                 


Gly Phe Ala Leu Ser Lys His Pro Ala Val Arg Thr Tyr Ser Trp Lys 
385                 390                 395                 400 


Lys Asp Ile Pro Ile Glu Val Cys Pro Ile Ser Asn Gln Val Leu Lys 
                405                 410                 415     


Leu Val Ser Asp Leu Arg Asn His Pro Val Ala Thr Leu Met Ala Thr 
            420                 425                 430         


Gly His Pro Met Val Ile Ser Ser Asp Asp Pro Ala Met Phe Gly Ala 
        435                 440                 445             


Lys Gly Leu Ser Tyr Asp Phe Tyr Glu Val Phe Met Gly Ile Gly Gly 
    450                 455                 460                 


Met Lys Ala Asp Leu Arg Thr Leu Lys Gln Leu Ala Met Asn Ser Ile 
465                 470                 475                 480 


Lys Tyr Ser Thr Leu Leu Glu Ser Glu Lys Asn Thr Phe Met Glu Ile 
                485                 490                 495     


Trp Lys Lys Arg Trp Asp Lys Phe Ile Ala Asp Val Ala Thr Lys Ser 
            500                 505                 510         


Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu 
        515                 520                 525             


Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln Ser Ser Ser Ser Lys 
    530                 535                 540                 


Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser 
545                 550                 555                 560 


Asp Thr Pro Ile Leu Pro Gln 
                565         


<210>  24
<211>  1704
<212>  DNA
<213>  Synthetic

<400>  24
atgttggtgg atggcccatc tgagcggcca gccctgtgct tcttgctgtt ggctgtggca       60

atgtctttct tcggctctgc tctatccata gatgaaacac gggcgcatct gttgttgaaa      120

gaaaagatga tgcggctggg ggggcggctg gtgctgaaca ccaaggagga gctggccaat      180

gagaggctca tgacgctcaa aatcgctgag atgaaggagg ccatgaggac cctgatattc      240

ccacccagca tgcacttttt ccaggccaag catctcattg agagaagtca agtgtttaat      300

attctaagga tgatgccaaa aggggctgcc ttgcacctcc atgacattgg catcgtgact      360

atggactggc tggtgaggaa tgtcacctac aggcctcact gccacatctg tttcacccca      420

agggggatca tgcagttcag atttgctcac ccaactcccc gtccatcaga aaaatgttcc      480

aagtggattc tgctggagga ttatcggaag cgggtgcaga acgtcactga gtttgatgac      540

agcttgctga ggaatttcac tctggtgacc cagcacccgg aggtgattta cacaaaccaa      600

aatgttgtct ggtcgaaatt tgaaaccatc ttcttcacca tctctggtct catccattac      660

gctccagtgt tcagagacta tgtcttccgg agcatgcagg agttctacga ggacaacgtg      720

ctctacatgg agatcagagc caggctgctg ccggtgtatg agctcagtgg agagcaccat      780

gacgaagagt ggtcagtgaa gacttatcag gaagtagctc agaagtttgt ggaaactcat      840

cctgagttta ttggaatcaa aatcatttat tcggatcaca gatccaaaga tgtggctgtc      900

atcgcagaat ccatccgaat ggccatgggg ctccgaatca agttccccac ggtggtggca      960

gggtttgacc tggtggggca tgaggacact ggccactcct tgcatgacta caaggaagct     1020

ctgatgatcc ccgccaagga tggcgttaag ctgccttact tcttccacgc cggagaaaca     1080

gactggcagg gtacttccat agacaggaac attctggatg ctctgatgct gaacactacc     1140

agaatcggcc atggatttgc tttgagcaaa caccccgcag tcaggactta ttcctggaaa     1200

aaggacatcc ccatagaagt ctgtcccatc tctaaccagg tgctgaaact ggtgtctgac     1260

ttgaggaacc accctgtagc cactctgatg gccactgggc accccatggt gatcagctct     1320

gatgacccag ctatgtttgg tgccaaaggc ttgtcctatg atttctatga ggtcttcatg     1380

ggcattgggg ggatgaaggc tgatctgagg accctcaaac agctggccat gaactctatc     1440

aagtacagta ccctgttgga gagtgagaaa aatactttca tggaaatatg gaagaagaga     1500

tgggataagt tcatagcaga tgtggctaca aagtcctctt cctcaaaggc acctccacct     1560

agccttccaa gtccatcccg actcccgggg ccctcggaca ccccgatcct cccacaatct     1620

tcctcttcca aagctccccc tccatcccta ccttctcctt cgcgtctccc tggtccttcc     1680

gatacaccaa ttctacccca gtga                                            1704


<210>  25
<211>  743
<212>  PRT
<213>  Synthetic

<400>  25

Met Leu Val Asp Gly Pro Ser Glu Arg Pro Ala Leu Cys Phe Leu Leu 
1               5                   10                  15      


Leu Ala Val Ala Met Ser Phe Phe Gly Ser Ala Leu Ser Ile Asp Glu 
            20                  25                  30          


Thr Arg Ala His Leu Leu Leu Lys Glu Lys Met Met Arg Leu Gly Gly 
        35                  40                  45              


Arg Leu Val Leu Asn Thr Lys Glu Glu Leu Ala Asn Glu Arg Leu Met 
    50                  55                  60                  


Thr Leu Lys Ile Ala Glu Met Lys Glu Ala Met Arg Thr Leu Ile Phe 
65                  70                  75                  80  


Pro Pro Ser Met His Phe Phe Gln Ala Lys His Leu Ile Glu Arg Ser 
                85                  90                  95      


Gln Val Phe Asn Ile Leu Arg Met Met Pro Lys Gly Ala Ala Leu His 
            100                 105                 110         


Leu His Asp Ile Gly Ile Val Thr Met Asp Trp Leu Val Arg Asn Val 
        115                 120                 125             


Thr Tyr Arg Pro His Cys His Ile Cys Phe Thr Pro Arg Gly Ile Met 
    130                 135                 140                 


Gln Phe Arg Phe Ala His Pro Thr Pro Arg Pro Ser Glu Lys Cys Ser 
145                 150                 155                 160 


Lys Trp Ile Leu Leu Glu Asp Tyr Arg Lys Arg Val Gln Asn Val Thr 
                165                 170                 175     


Glu Phe Asp Asp Ser Leu Leu Arg Asn Phe Thr Leu Val Thr Gln His 
            180                 185                 190         


Pro Glu Val Ile Tyr Thr Asn Gln Asn Val Val Trp Ser Lys Phe Glu 
        195                 200                 205             


Thr Ile Phe Phe Thr Ile Ser Gly Leu Ile His Tyr Ala Pro Val Phe 
    210                 215                 220                 


Arg Asp Tyr Val Phe Arg Ser Met Gln Glu Phe Tyr Glu Asp Asn Val 
225                 230                 235                 240 


Leu Tyr Met Glu Ile Arg Ala Arg Leu Leu Pro Val Tyr Glu Leu Ser 
                245                 250                 255     


Gly Glu His His Asp Glu Glu Trp Ser Val Lys Thr Tyr Gln Glu Val 
            260                 265                 270         


Ala Gln Lys Phe Val Glu Thr His Pro Glu Phe Ile Gly Ile Lys Ile 
        275                 280                 285             


Ile Tyr Ser Asp His Arg Ser Lys Asp Val Ala Val Ile Ala Glu Ser 
    290                 295                 300                 


Ile Arg Met Ala Met Gly Leu Arg Ile Lys Phe Pro Thr Val Val Ala 
305                 310                 315                 320 


Gly Phe Asp Leu Val Gly His Glu Asp Thr Gly His Ser Leu His Asp 
                325                 330                 335     


Tyr Lys Glu Ala Leu Met Ile Pro Ala Lys Asp Gly Val Lys Leu Pro 
            340                 345                 350         


Tyr Phe Phe His Ala Gly Glu Thr Asp Trp Gln Gly Thr Ser Ile Asp 
        355                 360                 365             


Arg Asn Ile Leu Asp Ala Leu Met Leu Asn Thr Thr Arg Ile Gly His 
    370                 375                 380                 


Gly Phe Ala Leu Ser Lys His Pro Ala Val Arg Thr Tyr Ser Trp Lys 
385                 390                 395                 400 


Lys Asp Ile Pro Ile Glu Val Cys Pro Ile Ser Asn Gln Val Leu Lys 
                405                 410                 415     


Leu Val Ser Asp Leu Arg Asn His Pro Val Ala Thr Leu Met Ala Thr 
            420                 425                 430         


Gly His Pro Met Val Ile Ser Ser Asp Asp Pro Ala Met Phe Gly Ala 
        435                 440                 445             


Lys Gly Leu Ser Tyr Asp Phe Tyr Glu Val Phe Met Gly Ile Gly Gly 
    450                 455                 460                 


Met Lys Ala Asp Leu Arg Thr Leu Lys Gln Leu Ala Met Asn Ser Ile 
465                 470                 475                 480 


Lys Tyr Ser Thr Leu Leu Glu Ser Glu Lys Asn Thr Phe Met Glu Ile 
                485                 490                 495     


Trp Lys Lys Arg Trp Asp Lys Phe Ile Ala Asp Val Ala Thr Lys Glu 
            500                 505                 510         


Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro 
        515                 520                 525             


Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    530                 535                 540                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
545                 550                 555                 560 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                565                 570                 575     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            580                 585                 590         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        595                 600                 605             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    610                 615                 620                 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
625                 630                 635                 640 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
                645                 650                 655     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            660                 665                 670         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        675                 680                 685             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    690                 695                 700                 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
705                 710                 715                 720 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                725                 730                 735     


Leu Ser Leu Ser Pro Gly Lys 
            740             


<210>  26
<211>  2232
<212>  DNA
<213>  Synthetic

<400>  26
atgttggtgg atggcccatc tgagcggcca gccctgtgct tcttgctgtt ggctgtggca       60

atgtctttct tcggctctgc tctatccata gatgaaacac gggcgcatct gttgttgaaa      120

gaaaagatga tgcggctggg ggggcggctg gtgctgaaca ccaaggagga gctggccaat      180

gagaggctca tgacgctcaa aatcgctgag atgaaggagg ccatgaggac cctgatattc      240

ccacccagca tgcacttttt ccaggccaag catctcattg agagaagtca agtgtttaat      300

attctaagga tgatgccaaa aggggctgcc ttgcacctcc atgacattgg catcgtgact      360

atggactggc tggtgaggaa tgtcacctac aggcctcact gccacatctg tttcacccca      420

agggggatca tgcagttcag atttgctcac ccaactcccc gtccatcaga aaaatgttcc      480

aagtggattc tgctggagga ttatcggaag cgggtgcaga acgtcactga gtttgatgac      540

agcttgctga ggaatttcac tctggtgacc cagcacccgg aggtgattta cacaaaccaa      600

aatgttgtct ggtcgaaatt tgaaaccatc ttcttcacca tctctggtct catccattac      660

gctccagtgt tcagagacta tgtcttccgg agcatgcagg agttctacga ggacaacgtg      720

ctctacatgg agatcagagc caggctgctg ccggtgtatg agctcagtgg agagcaccat      780

gacgaagagt ggtcagtgaa gacttatcag gaagtagctc agaagtttgt ggaaactcat      840

cctgagttta ttggaatcaa aatcatttat tcggatcaca gatccaaaga tgtggctgtc      900

atcgcagaat ccatccgaat ggccatgggg ctccgaatca agttccccac ggtggtggca      960

gggtttgacc tggtggggca tgaggacact ggccactcct tgcatgacta caaggaagct     1020

ctgatgatcc ccgccaagga tggcgttaag ctgccttact tcttccacgc cggagaaaca     1080

gactggcagg gtacttccat agacaggaac attctggatg ctctgatgct gaacactacc     1140

agaatcggcc atggatttgc tttgagcaaa caccccgcag tcaggactta ttcctggaaa     1200

aaggacatcc ccatagaagt ctgtcccatc tctaaccagg tgctgaaact ggtgtctgac     1260

ttgaggaacc accctgtagc cactctgatg gccactgggc accccatggt gatcagctct     1320

gatgacccag ctatgtttgg tgccaaaggc ttgtcctatg atttctatga ggtcttcatg     1380

ggcattgggg ggatgaaggc tgatctgagg accctcaaac agctggccat gaactctatc     1440

aagtacagta ccctgttgga gagtgagaaa aatactttca tggaaatatg gaagaagaga     1500

tgggataagt tcatagcaga tgtggctaca aaggagccca aatcttctga caaaactcac     1560

acatccccac cgtccccagc acctgaactc ctggggggat cgtcagtctt cctcttcccc     1620

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg     1680

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg     1740

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc     1800

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc     1860

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1920

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     1980

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     2040

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     2100

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     2160

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtcc     2220

ccgggtaaat ga                                                         2232


<210>  27
<211>  232
<212>  PRT
<213>  Synthetic

<400>  27

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  28
<211>  232
<212>  PRT
<213>  Synthetic

<400>  28

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  29
<211>  28
<212>  PRT
<213>  Synthetic

<400>  29

Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg 
1               5                   10                  15      


Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln 
            20                  25              


<210>  30
<211>  56
<212>  PRT
<213>  Synthetic

<400>  30

Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg 
1               5                   10                  15      


Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln Ser Ser Ser Ser 
            20                  25                  30          


Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro 
        35                  40                  45              


Ser Asp Thr Pro Ile Leu Pro Gln 
    50                  55      


<210>  31
<211>  9
<212>  PRT
<213>  Synthetic

<400>  31

Gly Gly Gly Ser Gly Gly Gly Ala Ser 
1               5                   


<210>  32
<211>  13
<212>  PRT
<213>  Synthetic

<400>  32

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ala Ser 
1               5                   10              


<210>  33
<211>  19
<212>  PRT
<213>  Synthetic

<400>  33

Ser His Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Ala Ser 
            


<210>  34
<211>  17
<212>  PRT
<213>  Synthetic

<400>  34

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ala 
1               5                   10                  15      


Ser 
    


<210>  35
<211>  5
<212>  PRT
<213>  Synthetic

<400>  35

Gly Gly Gly Ala Ser 
1               5   


<210>  36
<211>  1536
<212>  DNA
<213>  Synthetic

<400>  36
atgttggtgg atggcccatc tgagcggcca gccctgtgct tcttgctgtt ggctgtggca       60

atgtctttct tcggctctgc tctatccata gatgaaacac gggcgcatct gttgttgaaa      120

gaaaagatga tgcggctggg ggggcggctg gtgctgaaca ccaaggagga gctggccaat      180

gagaggctca tgacgctcaa aatcgctgag atgaaggagg ccatgaggac cctgatattc      240

ccacccagca tgcacttttt ccaggccaag catctcattg agagaagtca agtgtttaat      300

attctaagga tgatgccaaa aggggctgcc ttgcacctcc atgacattgg catcgtgact      360

atggactggc tggtgaggaa tgtcacctac aggcctcact gccacatctg tttcacccca      420

agggggatca tgcagttcag atttgctcac ccaactcccc gtccatcaga aaaatgttcc      480

aagtggattc tgctggagga ttatcggaag cgggtgcaga acgtcactga gtttgatgac      540

agcttgctga ggaatttcac tctggtgacc cagcacccgg aggtgattta cacaaaccaa      600

aatgttgtct ggtcgaaatt tgaaaccatc ttcttcacca tctctggtct catccattac      660

gctccagtgt tcagagacta tgtcttccgg agcatgcagg agttctacga ggacaacgtg      720

ctctacatgg agatcagagc caggctgctg ccggtgtatg agctcagtgg agagcaccat      780

gacgaagagt ggtcagtgaa gacttatcag gaagtagctc agaagtttgt ggaaactcat      840

cctgagttta ttggaatcaa aatcatttat tcggatcaca gatccaaaga tgtggctgtc      900

atcgcagaat ccatccgaat ggccatgggg ctccgaatca agttccccac ggtggtggca      960

gggtttgacc tggtggggca tgaggacact ggccactcct tgcatgacta caaggaagct     1020

ctgatgatcc ccgccaagga tggcgttaag ctgccttact tcttccacgc cggagaaaca     1080

gactggcagg gtacttccat agacaggaac attctggatg ctctgatgct gaacactacc     1140

agaatcggcc atggatttgc tttgagcaaa caccccgcag tcaggactta ttcctggaaa     1200

aaggacatcc ccatagaagt ctgtcccatc tctaaccagg tgctgaaact ggtgtctgac     1260

ttgaggaacc accctgtagc cactctgatg gccactgggc accccatggt gatcagctct     1320

gatgacccag ctatgtttgg tgccaaaggc ttgtcctatg atttctatga ggtcttcatg     1380

ggcattgggg ggatgaaggc tgatctgagg accctcaaac agctggccat gaactctatc     1440

aagtacagta ccctgttgga gagtgagaaa aatactttca tggaaatatg gaagaagaga     1500

tgggataagt tcatagcaga tgtggctaca aagtga                               1536


