                         SEQUENCE LISTING

<110>  VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.
 
<120>  VACCINES AND DIAGNOSTICS FOR NOVEL PORCINE ORTHOREOVIRUSES

<130>  124617-00411

<150>  62/080462
<151>  2014-11-17

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Orthoreovirus S1

<400>  1
tgggacaact tgagacagga                                                   20


<210>  2
<211>  20
<212>  DNA
<213>  Orthoreovirus S1

<400>  2
ctgaagtcca ccrttttgwa                                                   20


<210>  3
<211>  32
<212>  DNA
<213>  Orthoreovirus S1

<400>  3
cactctgata caatccttag gatcactcaa gg                                     32


<210>  4
<211>  30
<212>  DNA
<213>  Orthoreovirus S1

<400>  4
ccatcgtcat acgattgtta ttgattgcca                                        30


<210>  5
<211>  30
<212>  DNA
<213>  orthoreovirus

<400>  5
ctatactagc tgacacttcg atgggattgc                                        30


<210>  6
<211>  26
<212>  DNA
<213>  orthoreovirus

<400>  6
cgtctcatcc atttctgcca gctctt                                            26


<210>  7
<211>  3854
<212>  DNA
<213>  orthoreovirus

<400>  7
gctacacgtt ccacgacaat gtcatccatg atactgactc agtttggacc gttcattgaa       60

agcatctcag gtatcactga ccaatcgaac gacgtgtttg aagatgcagc aaaagcattc      120

tctacgttta ctcgcagcga cgtctataag gcgctggatg agataccttt ctctgatgac      180

gcgatgcttc ccatccctcc aactatatat accaaaccat ctcacgattc atattattac      240

atagatgctc taaaccgcgt acgtcgtaaa acatatcagg gccctgatga cgtgtacgta      300

cctaattgtt ccatcgttga attgctagag ccgcatgaga ctctgacatc ttatgggcgt      360

ttgtctgaag cgattgagaa tcgtgccaag gatggagaca gccaagccag aattgcgaca      420

acatacggta gaatcgctga gtctcaggct agacagatta aggctccatt ggagaagttt      480

gtgttggcac tattggtgtc cgaagcgggg ggttctctat atgacccagt tttgcagaag      540

tatgatgaga ttccagatct atcgcataat tgccctttat ggtgttttag agaaatctgt      600

cgtcacatat ctggtccatt accagatcga gcaccttatc tttacttatc ggcaggggtt      660

ttctggttaa tgtcaccacg gatgacgtct gcgatccctc cgttattatc tgatcttgtt      720

aatttagcta tcttacaaca gactgcaggt ttagatccat cattagtgaa attgggagtg      780

cagatatgtc ttcacgcagc agctagttcg agttatgcat ggtttatcct aaagactaag      840

tctatttttc ctcaaaacac gttacatagt atgtatgagt ctctagaagg agggtactgt      900

cctaacctag aatggttaga gcctagatcg gactataaat ttatgtacat gggagtcatg      960

ccattgtcca ctaaatatgc taggtcggca ccatccaacg aaaagaaagc gcgggaactt     1020

ggtgagaaat atggattgag ttcagttgtc agtgagcttc gtaaacggac aatggcttat     1080

gttaaacatg actttgcttc ggtaaggtac attcgtgacg ccatggcatg tactagcggc     1140

atttttctgg taagaacacc caccgagacg gtattgcaag aatataccca aagtccggag     1200

attaaggttc ccatccccca caaagactgg acaggcccag taggtgaaat cagaattcta     1260

aaagatacaa ccagctccat cgcgcgctac ttgtatagaa catggtactt agcagcggca     1320

agaatggcgg ctcagccacg cacgtgggat ccattgttcc aggcgattat gagatctcaa     1380

tacgtgacag ctaggggtgg gtctggcgca gcactccgcg aatctctgta tgcaattaat     1440

gtgtcgttac ctgattttaa gggcttacca gtgaaggcag caactaagat atttcaggcg     1500

gcacaattag cgaacctgcc gttctcacac acatcagtgg ctatactagc tgacacttcg     1560

atgggattgc gaaaccaggt gcagaggcga ccacgatcca tcatgccctt aaatgtgccc     1620

caacagcagg tttcggcgcc tcatacattg accgctgatt atatcaatta tcacatgaat     1680

ctatcgacta cgtctggtag cgcggtcatt gagaaagtga ttcctttagg tgtatacgct     1740

tcaagccctc ctaaccaatc gattaacatt gacatatctg cgtgcgacgc aagtattact     1800

tgggacttct ttctatccgt gattatggcg gctatacacg aaggtgtcgc tagtagctcc     1860

attggaaaac cgttcatggg agttcctgca tccatcgtaa atgatgagtc tgtcgttgga     1920

gtgagagctg ctaggccgat atcgggaatg cagaacatgg ttcagcatct atcaaaactg     1980

tacaaacgtg gattttcata tagagtgaac gactcttttt ctccaggcaa cgattttact     2040

catatgacta ccactttccc gtcaggttca acagccactt ctactgagca tactgccaat     2100

aatagtacga tgatggaaac tttcctgaca gtatggggac ccgaacatac tgacgacccc     2160

gacgtcttac gtctaatgaa gtctttgact attcaaagga attacgtgtg tcaaggtgat     2220

gatggattga tgattatcga tgggaatact gctggtaagg tgaaaagtga aactgttcag     2280

aagatgttgg agttaatctc aaaatatggt gaggagtttg gatggaaata tgacatagcg     2340

tacgatggga ctgccgagta cctaaagctg tacttcatat ttggctgtcg aattccaaat     2400

cttagccgtc atccaattgt tggaaaagaa cgggcgaatt cttcagcaga ggagccatgg     2460

ccagcaattt tagatcagat tatgggtatc ttctttaatg gcgttcatga cgggttgcag     2520

tggcagcggt ggatacgtta ttcatgggct ctatgctgtg ctttctcacg ccaaaggaca     2580

atgattggcg agagcgtggg ttacattcaa tatcctatgt ggtcatttgt ctactgggga     2640

ttaccattgg taaaagtgtt cgggtcagac ccatggatat tctcttggta catgccgact     2700

ggggacttgg gaatgtatag ttggattagc ctaatacgcc ctctaatgac aagatggatg     2760

gtagctaatg gctatgtcac tgacaaatgc tcacccgtat tcgggaacgc agattatcgt     2820

aaatgtttca atgagattaa attatatcaa gggtattata tggcacaatt gcccaggaat     2880

cccacaaaat ctggacgagc ggcccctcgg gaggtgagag aacaatttac tcaggcacta     2940

tctgattatc tgatgcaaaa tccagaactg aagtcacgtg tgctacgtgg tcgtagtgag     3000

tgggagaagt atggagccgg gataattcac aaccctccat cattattcga tgtcccccat     3060

aagtggtatc agggtgcgca agaggcggcg accgctacga gagaagagct ggcagaaatg     3120

gatgagacgt tgatacgcgc ccgaaggcac agttattcga gtttctcaaa attgttggag     3180

gcatacctgc ttgtgaaatg gcgaatgtgc gaggcccgcg aaccgtcggt tgatttgcga     3240

ttaccattgt gtgcgggtat tgacccacta aactcagatc cttttctcaa aatggtaagc     3300

gttggaccga tgcttcagag tacgcgaaag tactttgctc agacactatt catggcgaaa     3360

acggtgtcgg gtctcgacgt taacgcgatt gatagcgcgt tattacgact gcgaacattg     3420

ggcgctgata agaaagcatt aacagcgcag ttattaatgg tgggacttca ggagtcagag     3480

gcggatgcgt tggctgggaa gataatgttg caagatgtaa gtactgtgca attagctaga     3540

gtggtcaatt tagcggtgcc agatacgtgg atgtcgttgg attttgattc tatgttcaaa     3600

caccatgtta aattgcttcc caaagatgga cgccacctaa atactgacat tcctcctcgc     3660

atgggatggt tacgggccat tctacgattc ctaggtgctg gaatggtaat gactgcgact     3720

ggagttgctg tcgacatata tctggaggat atacacggtg gtggtcgatc acttggacag     3780

agattcatga cttggatgcg gcaggaagga cggtcagcgt gagtctacca tgggtcgtgg     3840

tgcgtcaact catc                                                       3854


<210>  8
<211>  1267
<212>  PRT
<213>  orthoreovirus

<400>  8

Met Ser Ser Met Ile Leu Thr Gln Phe Gly Pro Phe Ile Glu Ser Ile 
1               5                   10                  15      


Ser Gly Ile Thr Asp Gln Ser Asn Asp Val Phe Glu Asp Ala Ala Lys 
            20                  25                  30          


Ala Phe Ser Thr Phe Thr Arg Ser Asp Val Tyr Lys Ala Leu Asp Glu 
        35                  40                  45              


Ile Pro Phe Ser Asp Asp Ala Met Leu Pro Ile Pro Pro Thr Ile Tyr 
    50                  55                  60                  


Thr Lys Pro Ser His Asp Ser Tyr Tyr Tyr Ile Asp Ala Leu Asn Arg 
65                  70                  75                  80  


Val Arg Arg Lys Thr Tyr Gln Gly Pro Asp Asp Val Tyr Val Pro Asn 
                85                  90                  95      


Cys Ser Ile Val Glu Leu Leu Glu Pro His Glu Thr Leu Thr Ser Tyr 
            100                 105                 110         


Gly Arg Leu Ser Glu Ala Ile Glu Asn Arg Ala Lys Asp Gly Asp Ser 
        115                 120                 125             


Gln Ala Arg Ile Ala Thr Thr Tyr Gly Arg Ile Ala Glu Ser Gln Ala 
    130                 135                 140                 


Arg Gln Ile Lys Ala Pro Leu Glu Lys Phe Val Leu Ala Leu Leu Val 
145                 150                 155                 160 


Ser Glu Ala Gly Gly Ser Leu Tyr Asp Pro Val Leu Gln Lys Tyr Asp 
                165                 170                 175     


Glu Ile Pro Asp Leu Ser His Asn Cys Pro Leu Trp Cys Phe Arg Glu 
            180                 185                 190         


Ile Cys Arg His Ile Ser Gly Pro Leu Pro Asp Arg Ala Pro Tyr Leu 
        195                 200                 205             


Tyr Leu Ser Ala Gly Val Phe Trp Leu Met Ser Pro Arg Met Thr Ser 
    210                 215                 220                 


Ala Ile Pro Pro Leu Leu Ser Asp Leu Val Asn Leu Ala Ile Leu Gln 
225                 230                 235                 240 


Gln Thr Ala Gly Leu Asp Pro Ser Leu Val Lys Leu Gly Val Gln Ile 
                245                 250                 255     


Cys Leu His Ala Ala Ala Ser Ser Ser Tyr Ala Trp Phe Ile Leu Lys 
            260                 265                 270         


Thr Lys Ser Ile Phe Pro Gln Asn Thr Leu His Ser Met Tyr Glu Ser 
        275                 280                 285             


Leu Glu Gly Gly Tyr Cys Pro Asn Leu Glu Trp Leu Glu Pro Arg Ser 
    290                 295                 300                 


Asp Tyr Lys Phe Met Tyr Met Gly Val Met Pro Leu Ser Thr Lys Tyr 
305                 310                 315                 320 


Ala Arg Ser Ala Pro Ser Asn Glu Lys Lys Ala Arg Glu Leu Gly Glu 
                325                 330                 335     


Lys Tyr Gly Leu Ser Ser Val Val Ser Glu Leu Arg Lys Arg Thr Met 
            340                 345                 350         


Ala Tyr Val Lys His Asp Phe Ala Ser Val Arg Tyr Ile Arg Asp Ala 
        355                 360                 365             


Met Ala Cys Thr Ser Gly Ile Phe Leu Val Arg Thr Pro Thr Glu Thr 
    370                 375                 380                 


Val Leu Gln Glu Tyr Thr Gln Ser Pro Glu Ile Lys Val Pro Ile Pro 
385                 390                 395                 400 


His Lys Asp Trp Thr Gly Pro Val Gly Glu Ile Arg Ile Leu Lys Asp 
                405                 410                 415     


Thr Thr Ser Ser Ile Ala Arg Tyr Leu Tyr Arg Thr Trp Tyr Leu Ala 
            420                 425                 430         


Ala Ala Arg Met Ala Ala Gln Pro Arg Thr Trp Asp Pro Leu Phe Gln 
        435                 440                 445             


Ala Ile Met Arg Ser Gln Tyr Val Thr Ala Arg Gly Gly Ser Gly Ala 
    450                 455                 460                 


Ala Leu Arg Glu Ser Leu Tyr Ala Ile Asn Val Ser Leu Pro Asp Phe 
465                 470                 475                 480 


Lys Gly Leu Pro Val Lys Ala Ala Thr Lys Ile Phe Gln Ala Ala Gln 
                485                 490                 495     


Leu Ala Asn Leu Pro Phe Ser His Thr Ser Val Ala Ile Leu Ala Asp 
            500                 505                 510         


Thr Ser Met Gly Leu Arg Asn Gln Val Gln Arg Arg Pro Arg Ser Ile 
        515                 520                 525             


Met Pro Leu Asn Val Pro Gln Gln Gln Val Ser Ala Pro His Thr Leu 
    530                 535                 540                 


Thr Ala Asp Tyr Ile Asn Tyr His Met Asn Leu Ser Thr Thr Ser Gly 
545                 550                 555                 560 


Ser Ala Val Ile Glu Lys Val Ile Pro Leu Gly Val Tyr Ala Ser Ser 
                565                 570                 575     


Pro Pro Asn Gln Ser Ile Asn Ile Asp Ile Ser Ala Cys Asp Ala Ser 
            580                 585                 590         


Ile Thr Trp Asp Phe Phe Leu Ser Val Ile Met Ala Ala Ile His Glu 
        595                 600                 605             


Gly Val Ala Ser Ser Ser Ile Gly Lys Pro Phe Met Gly Val Pro Ala 
    610                 615                 620                 


Ser Ile Val Asn Asp Glu Ser Val Val Gly Val Arg Ala Ala Arg Pro 
625                 630                 635                 640 


Ile Ser Gly Met Gln Asn Met Val Gln His Leu Ser Lys Leu Tyr Lys 
                645                 650                 655     


Arg Gly Phe Ser Tyr Arg Val Asn Asp Ser Phe Ser Pro Gly Asn Asp 
            660                 665                 670         


Phe Thr His Met Thr Thr Thr Phe Pro Ser Gly Ser Thr Ala Thr Ser 
        675                 680                 685             


Thr Glu His Thr Ala Asn Asn Ser Thr Met Met Glu Thr Phe Leu Thr 
    690                 695                 700                 


Val Trp Gly Pro Glu His Thr Asp Asp Pro Asp Val Leu Arg Leu Met 
705                 710                 715                 720 


Lys Ser Leu Thr Ile Gln Arg Asn Tyr Val Cys Gln Gly Asp Asp Gly 
                725                 730                 735     


Leu Met Ile Ile Asp Gly Asn Thr Ala Gly Lys Val Lys Ser Glu Thr 
            740                 745                 750         


Val Gln Lys Met Leu Glu Leu Ile Ser Lys Tyr Gly Glu Glu Phe Gly 
        755                 760                 765             


Trp Lys Tyr Asp Ile Ala Tyr Asp Gly Thr Ala Glu Tyr Leu Lys Leu 
    770                 775                 780                 


Tyr Phe Ile Phe Gly Cys Arg Ile Pro Asn Leu Ser Arg His Pro Ile 
785                 790                 795                 800 


Val Gly Lys Glu Arg Ala Asn Ser Ser Ala Glu Glu Pro Trp Pro Ala 
                805                 810                 815     


Ile Leu Asp Gln Ile Met Gly Ile Phe Phe Asn Gly Val His Asp Gly 
            820                 825                 830         


Leu Gln Trp Gln Arg Trp Ile Arg Tyr Ser Trp Ala Leu Cys Cys Ala 
        835                 840                 845             


Phe Ser Arg Gln Arg Thr Met Ile Gly Glu Ser Val Gly Tyr Ile Gln 
    850                 855                 860                 


Tyr Pro Met Trp Ser Phe Val Tyr Trp Gly Leu Pro Leu Val Lys Val 
865                 870                 875                 880 


Phe Gly Ser Asp Pro Trp Ile Phe Ser Trp Tyr Met Pro Thr Gly Asp 
                885                 890                 895     


Leu Gly Met Tyr Ser Trp Ile Ser Leu Ile Arg Pro Leu Met Thr Arg 
            900                 905                 910         


Trp Met Val Ala Asn Gly Tyr Val Thr Asp Lys Cys Ser Pro Val Phe 
        915                 920                 925             


Gly Asn Ala Asp Tyr Arg Lys Cys Phe Asn Glu Ile Lys Leu Tyr Gln 
    930                 935                 940                 


Gly Tyr Tyr Met Ala Gln Leu Pro Arg Asn Pro Thr Lys Ser Gly Arg 
945                 950                 955                 960 


Ala Ala Pro Arg Glu Val Arg Glu Gln Phe Thr Gln Ala Leu Ser Asp 
                965                 970                 975     


Tyr Leu Met Gln Asn Pro Glu Leu Lys Ser Arg Val Leu Arg Gly Arg 
            980                 985                 990         


Ser Glu Trp Glu Lys Tyr Gly Ala  Gly Ile Ile His Asn  Pro Pro Ser 
        995                 1000                 1005             


Leu Phe  Asp Val Pro His Lys  Trp Tyr Gln Gly Ala  Gln Glu Ala 
    1010                 1015                 1020             


Ala Thr  Ala Thr Arg Glu Glu  Leu Ala Glu Met Asp  Glu Thr Leu 
    1025                 1030                 1035             


Ile Arg  Ala Arg Arg His Ser  Tyr Ser Ser Phe Ser  Lys Leu Leu 
    1040                 1045                 1050             


Glu Ala  Tyr Leu Leu Val Lys  Trp Arg Met Cys Glu  Ala Arg Glu 
    1055                 1060                 1065             


Pro Ser  Val Asp Leu Arg Leu  Pro Leu Cys Ala Gly  Ile Asp Pro 
    1070                 1075                 1080             


Leu Asn  Ser Asp Pro Phe Leu  Lys Met Val Ser Val  Gly Pro Met 
    1085                 1090                 1095             


Leu Gln  Ser Thr Arg Lys Tyr  Phe Ala Gln Thr Leu  Phe Met Ala 
    1100                 1105                 1110             


Lys Thr  Val Ser Gly Leu Asp  Val Asn Ala Ile Asp  Ser Ala Leu 
    1115                 1120                 1125             


Leu Arg  Leu Arg Thr Leu Gly  Ala Asp Lys Lys Ala  Leu Thr Ala 
    1130                 1135                 1140             


Gln Leu  Leu Met Val Gly Leu  Gln Glu Ser Glu Ala  Asp Ala Leu 
    1145                 1150                 1155             


Ala Gly  Lys Ile Met Leu Gln  Asp Val Ser Thr Val  Gln Leu Ala 
    1160                 1165                 1170             


Arg Val  Val Asn Leu Ala Val  Pro Asp Thr Trp Met  Ser Leu Asp 
    1175                 1180                 1185             


Phe Asp  Ser Met Phe Lys His  His Val Lys Leu Leu  Pro Lys Asp 
    1190                 1195                 1200             


Gly Arg  His Leu Asn Thr Asp  Ile Pro Pro Arg Met  Gly Trp Leu 
    1205                 1210                 1215             


Arg Ala  Ile Leu Arg Phe Leu  Gly Ala Gly Met Val  Met Thr Ala 
    1220                 1225                 1230             


Thr Gly  Val Ala Val Asp Ile  Tyr Leu Glu Asp Ile  His Gly Gly 
    1235                 1240                 1245             


Gly Arg  Ser Leu Gly Gln Arg  Phe Met Thr Trp Met  Arg Gln Glu 
    1250                 1255                 1260             


Gly Arg  Ser Ala 
    1265         


<210>  9
<211>  3915
<212>  DNA
<213>  orthoreovirus

<400>  9
gctattggcg caatggcgaa cgtttgggga gtgagacttg cagactcttt atcgtcaccc       60

actattgaga caagaactcg tcattacaca ctccgcgatt tctgttccga cctggatgct      120

gtagttggca aggaaccctg gagaccctta cgcaatcaga gaacgaatga tattgtcgcc      180

gttcaattgt ttcggccact gcagggattg gtgcttgaca cgcagtttta tggattccct      240

ggcattttct cagaatggga acagtttata agagagaaac tacgcgtgtt gaaatatgaa      300

gttttgcgga tttacccgat cagtaattat aatcatgagc gtgtcaatgt cttcgtggca      360

aatgctcttg tcggtgcatt tctatccaac caagccttct atgacctgtt gcctctatta      420

ttaatacgtg ataccatgat aaatgactta cttgggacag gtgctgctct ttctcagttt      480

ttccaatctc atggtgaggt tttagaggtt gccgcaggaa ggaagtacct gcaaatgaag      540

aactactcga acgatgatga tgatccacct ttattcgcta aggatctgtc ggattatgcg      600

aaggcgtttt acagtgatac gtttgagact ttagaccgat tcttctggac acatgactca      660

tctgcgggcg tcctagtgca ttatgataag cctaccaatg ggaatcatta catcttgggt      720

actctgacgc agatggttag tgcgcctccg catatcatta acgctactga cgcattgttg      780

ctcgaatcgt gtttagaaca atttgcggag aatgtgagag ccaggccagc gcagcctgtt      840

ccaagattgg atcagtgtta ccatttacgg tggggtgctc aatatgttgg cgaggactca      900

ttgacgtacc gtttgggggt actttcacta ctggctacca acggatatca attagctaga      960

ccgatcccta agcagttaac gaatcgatgg ctttctagtt ttgtcagtca gataatgtcg     1020

gatggtgtga atgagacgcc attatggcct caagagagat atgtccaaat agcctacgat     1080

tcaccgtctg tagtcgacgg agctacgcac tatggttatg ttaggagaaa tcagttgcgg     1140

ttgggcatga gggtgtccgc tcttcagtca ttgagtgata ctccggctcc gatacagtgg     1200

ttaccgcagt atactattga tcaggcacct gttgatgagg gagatctaat ggtttcgcgg     1260

ttgactcaac taccgttacg ccctgattat ggtagcatat gggtcggtga cgctctatcg     1320

tattatgttg attacaaccg cagccataga gttgtactat catccgagct accacaacta     1380

ccagatacat actttgacgg agacgagcaa tacggtcgca gtctgttctc tttagcacga     1440

aaaatcggtg atcgatctct catcaaagat acagcagtgc tcaagcatgc gtaccaggcc     1500

atcgatccaa acactggaaa ggaatacctt cgcgcaggac agtctgttgc atatttcgga     1560

gcatcagctg gtcattcagg ggcggatcaa cctctagtaa ttgagccatg gacgcagggt     1620

aaaattagtg gtgtaccgca gccttcttca gtcagacagt ttgggtatga tgttgctaaa     1680

ggtgcgattg tggacttagc aagaccgttc ccgtcgggtg actaccaatt tgtatattct     1740

gacgtcgatc aggtcgttga cggccacgat gatctcagca tatcttcagg gctggtggag     1800

agtctattag attcctgcat gcatgccaca tccccaggtg ggtcgttcgt gatgaagata     1860

aatttcccga cacgtgatgt ctggcactat atagagcaaa agattctccc aaatattacc     1920

tcgtacatgt tgatcaaacc attcgtgact aacaatgtag agttattctt tgtggctttc     1980

ggtgtgcatc aacaatcagc attgacatgg acgtccgggg tgtatttctt cctggtcgat     2040

cacttctatc gatacgagac attgtctacg atttcacgtc agttgccatc gttcggatac     2100

gttgatgacg ggtcgtctgt gacaggtatt gagatgatca gtcttgaaaa tccaggcttt     2160

tcaaacatga cccaagctgc acgtgtcggg atatcagggc tgtgtgcgaa tgtcggtaat     2220

gcgcgcaaat taatatctat ccatgaatct cacggagcac gcgtgctcac catcatatcg     2280

agaagatctc cggcttcggc taggcggaaa gctcgcttac gctatttgcc actcatagac     2340

ccacgatctt tggaagtgca ggcacgtacg atattaccat ctaacccagt gctgtttgac     2400

aacgtaaaag gagcatcgcc tcacgtatgt ttgacgatga tgtataactt tgaagtatct     2460

agtgcggtgt atgatggtga tgtagtgctt gaccttggta ccggtcctga agcgaagatt     2520

ctggagctga ttcctccaac gtccccagta acatgcgtgg acattagacc gacggcacag     2580

cctagtggct gttggaacgt acgtacgaca tttctggagc ttgattacct aagtgatggc     2640

tggataacgg gtgtacgtgg cgacatcgtg acctgcatgc tgtccctggg tgctgctgct     2700

gctggaaaat ccatgacgtt cgacgcggca tttcaacagt tagtgaaagt gcttactaaa     2760

agtacagcta acgtactgct gatccaagtc aactgcccaa cggatgtaat ccgaacaatt     2820

aagggatatt tggagataga tcaaactaat aagcggtata gatttcccaa atttggccgt     2880

gatgaaccat actctgacat ggattcctta gagcgcatat gtcgtgctgc gtggccaaat     2940

tgttccatca cgtgggtgcc tttatcctat gatctacgtt ggactaaact tgctttgctt     3000

gaatcgacta cactgagcag tgcatcagtg agaattgctg agttgatgta caaatacatg     3060

ccagttatga ggatagatat tcatgggtta cccatggaaa agcaaggcaa tttcgtagtg     3120

ggtcagaact gttctctaac tataccgggc ttcaacgcac aggacgtgtt caactgctac     3180

ttcaattccg cgctcgcttt ctctactgag gatgttaatt cggcaatgat accacaagtg     3240

acggctcagt ttaacactag taaaggtgag tggtcattgg acatggtgtt ctcagacgct     3300

ggtatctaca caatgcaggc attagtaggt tccaacgcaa atcctgtgtc tttgggttcg     3360

tttgtagtgg attctccgga tgtcgacata acagatgcgt ggcctgctca gttagatttt     3420

accatagctg gcactgatgt caacatcaca gttaatcctt attaccgctt gatggccttt     3480

gtaaagattg atggacaatg gcagattgcg aaccctgata aattccaatt tttctcatca     3540

ggtacaggga cgttagtgat gaatgtaaag ttagatatag ctgataggta tttgctatat     3600

tacattcgcg acgttcaatc tagggatgtg ggattttaca tacagcaccc attacagtta     3660

ttaaatacaa ttacgttgcc tacaaacgag gatttattct tgagcgctcc tgacatgcgc     3720

gagtgggcgg taaaggaaag tggcaatacc atatgcatac ttaatagcca gggttttgtg     3780

ccacctcagg attgggatgt tcttaccgac actattagct ggtctccttc gctcccaact     3840

tatgtggtac ctccgggtga ttatactctg acacctctgt aactcattac ccctcgtaag     3900

cgtgcctaat tcatc                                                      3915


<210>  10
<211>  1289
<212>  PRT
<213>  orthoreovirus

<400>  10

Met Ala Asn Val Trp Gly Val Arg Leu Ala Asp Ser Leu Ser Ser Pro 
1               5                   10                  15      


Thr Ile Glu Thr Arg Thr Arg His Tyr Thr Leu Arg Asp Phe Cys Ser 
            20                  25                  30          


Asp Leu Asp Ala Val Val Gly Lys Glu Pro Trp Arg Pro Leu Arg Asn 
        35                  40                  45              


Gln Arg Thr Asn Asp Ile Val Ala Val Gln Leu Phe Arg Pro Leu Gln 
    50                  55                  60                  


Gly Leu Val Leu Asp Thr Gln Phe Tyr Gly Phe Pro Gly Ile Phe Ser 
65                  70                  75                  80  


Glu Trp Glu Gln Phe Ile Arg Glu Lys Leu Arg Val Leu Lys Tyr Glu 
                85                  90                  95      


Val Leu Arg Ile Tyr Pro Ile Ser Asn Tyr Asn His Glu Arg Val Asn 
            100                 105                 110         


Val Phe Val Ala Asn Ala Leu Val Gly Ala Phe Leu Ser Asn Gln Ala 
        115                 120                 125             


Phe Tyr Asp Leu Leu Pro Leu Leu Leu Ile Arg Asp Thr Met Ile Asn 
    130                 135                 140                 


Asp Leu Leu Gly Thr Gly Ala Ala Leu Ser Gln Phe Phe Gln Ser His 
145                 150                 155                 160 


Gly Glu Val Leu Glu Val Ala Ala Gly Arg Lys Tyr Leu Gln Met Lys 
                165                 170                 175     


Asn Tyr Ser Asn Asp Asp Asp Asp Pro Pro Leu Phe Ala Lys Asp Leu 
            180                 185                 190         


Ser Asp Tyr Ala Lys Ala Phe Tyr Ser Asp Thr Phe Glu Thr Leu Asp 
        195                 200                 205             


Arg Phe Phe Trp Thr His Asp Ser Ser Ala Gly Val Leu Val His Tyr 
    210                 215                 220                 


Asp Lys Pro Thr Asn Gly Asn His Tyr Ile Leu Gly Thr Leu Thr Gln 
225                 230                 235                 240 


Met Val Ser Ala Pro Pro His Ile Ile Asn Ala Thr Asp Ala Leu Leu 
                245                 250                 255     


Leu Glu Ser Cys Leu Glu Gln Phe Ala Glu Asn Val Arg Ala Arg Pro 
            260                 265                 270         


Ala Gln Pro Val Pro Arg Leu Asp Gln Cys Tyr His Leu Arg Trp Gly 
        275                 280                 285             


Ala Gln Tyr Val Gly Glu Asp Ser Leu Thr Tyr Arg Leu Gly Val Leu 
    290                 295                 300                 


Ser Leu Leu Ala Thr Asn Gly Tyr Gln Leu Ala Arg Pro Ile Pro Lys 
305                 310                 315                 320 


Gln Leu Thr Asn Arg Trp Leu Ser Ser Phe Val Ser Gln Ile Met Ser 
                325                 330                 335     


Asp Gly Val Asn Glu Thr Pro Leu Trp Pro Gln Glu Arg Tyr Val Gln 
            340                 345                 350         


Ile Ala Tyr Asp Ser Pro Ser Val Val Asp Gly Ala Thr His Tyr Gly 
        355                 360                 365             


Tyr Val Arg Arg Asn Gln Leu Arg Leu Gly Met Arg Val Ser Ala Leu 
    370                 375                 380                 


Gln Ser Leu Ser Asp Thr Pro Ala Pro Ile Gln Trp Leu Pro Gln Tyr 
385                 390                 395                 400 


Thr Ile Asp Gln Ala Pro Val Asp Glu Gly Asp Leu Met Val Ser Arg 
                405                 410                 415     


Leu Thr Gln Leu Pro Leu Arg Pro Asp Tyr Gly Ser Ile Trp Val Gly 
            420                 425                 430         


Asp Ala Leu Ser Tyr Tyr Val Asp Tyr Asn Arg Ser His Arg Val Val 
        435                 440                 445             


Leu Ser Ser Glu Leu Pro Gln Leu Pro Asp Thr Tyr Phe Asp Gly Asp 
    450                 455                 460                 


Glu Gln Tyr Gly Arg Ser Leu Phe Ser Leu Ala Arg Lys Ile Gly Asp 
465                 470                 475                 480 


Arg Ser Leu Ile Lys Asp Thr Ala Val Leu Lys His Ala Tyr Gln Ala 
                485                 490                 495     


Ile Asp Pro Asn Thr Gly Lys Glu Tyr Leu Arg Ala Gly Gln Ser Val 
            500                 505                 510         


Ala Tyr Phe Gly Ala Ser Ala Gly His Ser Gly Ala Asp Gln Pro Leu 
        515                 520                 525             


Val Ile Glu Pro Trp Thr Gln Gly Lys Ile Ser Gly Val Pro Gln Pro 
    530                 535                 540                 


Ser Ser Val Arg Gln Phe Gly Tyr Asp Val Ala Lys Gly Ala Ile Val 
545                 550                 555                 560 


Asp Leu Ala Arg Pro Phe Pro Ser Gly Asp Tyr Gln Phe Val Tyr Ser 
                565                 570                 575     


Asp Val Asp Gln Val Val Asp Gly His Asp Asp Leu Ser Ile Ser Ser 
            580                 585                 590         


Gly Leu Val Glu Ser Leu Leu Asp Ser Cys Met His Ala Thr Ser Pro 
        595                 600                 605             


Gly Gly Ser Phe Val Met Lys Ile Asn Phe Pro Thr Arg Asp Val Trp 
    610                 615                 620                 


His Tyr Ile Glu Gln Lys Ile Leu Pro Asn Ile Thr Ser Tyr Met Leu 
625                 630                 635                 640 


Ile Lys Pro Phe Val Thr Asn Asn Val Glu Leu Phe Phe Val Ala Phe 
                645                 650                 655     


Gly Val His Gln Gln Ser Ala Leu Thr Trp Thr Ser Gly Val Tyr Phe 
            660                 665                 670         


Phe Leu Val Asp His Phe Tyr Arg Tyr Glu Thr Leu Ser Thr Ile Ser 
        675                 680                 685             


Arg Gln Leu Pro Ser Phe Gly Tyr Val Asp Asp Gly Ser Ser Val Thr 
    690                 695                 700                 


Gly Ile Glu Met Ile Ser Leu Glu Asn Pro Gly Phe Ser Asn Met Thr 
705                 710                 715                 720 


Gln Ala Ala Arg Val Gly Ile Ser Gly Leu Cys Ala Asn Val Gly Asn 
                725                 730                 735     


Ala Arg Lys Leu Ile Ser Ile His Glu Ser His Gly Ala Arg Val Leu 
            740                 745                 750         


Thr Ile Ile Ser Arg Arg Ser Pro Ala Ser Ala Arg Arg Lys Ala Arg 
        755                 760                 765             


Leu Arg Tyr Leu Pro Leu Ile Asp Pro Arg Ser Leu Glu Val Gln Ala 
    770                 775                 780                 


Arg Thr Ile Leu Pro Ser Asn Pro Val Leu Phe Asp Asn Val Lys Gly 
785                 790                 795                 800 


Ala Ser Pro His Val Cys Leu Thr Met Met Tyr Asn Phe Glu Val Ser 
                805                 810                 815     


Ser Ala Val Tyr Asp Gly Asp Val Val Leu Asp Leu Gly Thr Gly Pro 
            820                 825                 830         


Glu Ala Lys Ile Leu Glu Leu Ile Pro Pro Thr Ser Pro Val Thr Cys 
        835                 840                 845             


Val Asp Ile Arg Pro Thr Ala Gln Pro Ser Gly Cys Trp Asn Val Arg 
    850                 855                 860                 


Thr Thr Phe Leu Glu Leu Asp Tyr Leu Ser Asp Gly Trp Ile Thr Gly 
865                 870                 875                 880 


Val Arg Gly Asp Ile Val Thr Cys Met Leu Ser Leu Gly Ala Ala Ala 
                885                 890                 895     


Ala Gly Lys Ser Met Thr Phe Asp Ala Ala Phe Gln Gln Leu Val Lys 
            900                 905                 910         


Val Leu Thr Lys Ser Thr Ala Asn Val Leu Leu Ile Gln Val Asn Cys 
        915                 920                 925             


Pro Thr Asp Val Ile Arg Thr Ile Lys Gly Tyr Leu Glu Ile Asp Gln 
    930                 935                 940                 


Thr Asn Lys Arg Tyr Arg Phe Pro Lys Phe Gly Arg Asp Glu Pro Tyr 
945                 950                 955                 960 


Ser Asp Met Asp Ser Leu Glu Arg Ile Cys Arg Ala Ala Trp Pro Asn 
                965                 970                 975     


Cys Ser Ile Thr Trp Val Pro Leu Ser Tyr Asp Leu Arg Trp Thr Lys 
            980                 985                 990         


Leu Ala Leu Leu Glu Ser Thr Thr  Leu Ser Ser Ala Ser  Val Arg Ile 
        995                 1000                 1005             


Ala Glu  Leu Met Tyr Lys Tyr  Met Pro Val Met Arg  Ile Asp Ile 
    1010                 1015                 1020             


His Gly  Leu Pro Met Glu Lys  Gln Gly Asn Phe Val  Val Gly Gln 
    1025                 1030                 1035             


Asn Cys  Ser Leu Thr Ile Pro  Gly Phe Asn Ala Gln  Asp Val Phe 
    1040                 1045                 1050             


Asn Cys  Tyr Phe Asn Ser Ala  Leu Ala Phe Ser Thr  Glu Asp Val 
    1055                 1060                 1065             


Asn Ser  Ala Met Ile Pro Gln  Val Thr Ala Gln Phe  Asn Thr Ser 
    1070                 1075                 1080             


Lys Gly  Glu Trp Ser Leu Asp  Met Val Phe Ser Asp  Ala Gly Ile 
    1085                 1090                 1095             


Tyr Thr  Met Gln Ala Leu Val  Gly Ser Asn Ala Asn  Pro Val Ser 
    1100                 1105                 1110             


Leu Gly  Ser Phe Val Val Asp  Ser Pro Asp Val Asp  Ile Thr Asp 
    1115                 1120                 1125             


Ala Trp  Pro Ala Gln Leu Asp  Phe Thr Ile Ala Gly  Thr Asp Val 
    1130                 1135                 1140             


Asn Ile  Thr Val Asn Pro Tyr  Tyr Arg Leu Met Ala  Phe Val Lys 
    1145                 1150                 1155             


Ile Asp  Gly Gln Trp Gln Ile  Ala Asn Pro Asp Lys  Phe Gln Phe 
    1160                 1165                 1170             


Phe Ser  Ser Gly Thr Gly Thr  Leu Val Met Asn Val  Lys Leu Asp 
    1175                 1180                 1185             


Ile Ala  Asp Arg Tyr Leu Leu  Tyr Tyr Ile Arg Asp  Val Gln Ser 
    1190                 1195                 1200             


Arg Asp  Val Gly Phe Tyr Ile  Gln His Pro Leu Gln  Leu Leu Asn 
    1205                 1210                 1215             


Thr Ile  Thr Leu Pro Thr Asn  Glu Asp Leu Phe Leu  Ser Ala Pro 
    1220                 1225                 1230             


Asp Met  Arg Glu Trp Ala Val  Lys Glu Ser Gly Asn  Thr Ile Cys 
    1235                 1240                 1245             


Ile Leu  Asn Ser Gln Gly Phe  Val Pro Pro Gln Asp  Trp Asp Val 
    1250                 1255                 1260             


Leu Thr  Asp Thr Ile Ser Trp  Ser Pro Ser Leu Pro  Thr Tyr Val 
    1265                 1270                 1275             


Val Pro  Pro Gly Asp Tyr Thr  Leu Thr Pro Leu 
    1280                 1285                 


<210>  11
<211>  3901
<212>  DNA
<213>  orthoreovirus

<400>  11
gctaatcgtc aggatgaagc ggattccaag gaagacaaag ggcaaatcca gcggaaaggg       60

caatgactcg acagatagag cggacgatgg ctcgagccaa ttacgagata agcaaaacaa      120

taagaccggc cccgccactg cagagcctgg aacgtccaac cgagagcgat acaaagctcg      180

accaagtatt gcatctgtgc agagggccac tgaaagtgca gaactgccca tcaagaataa      240

tgacgaagga acgccagata agaaaggaaa tactaagggc gacttagttg gtgggcatag      300

tgaggctaaa gatgaggcgg atgaagcgac gaagaagcag gcaaaagata cagataaaag      360

taaagcgcaa gtcacatatt cagacactgg tatcaataat gctaatgaac tgtcaagatc      420

tgggaatgtg gataatgagg gtggaagtaa tcagaaaccg atgtccacca gaatagctga      480

agcaacgtct gctatagtgt ctaaacatcc tgcgcgtgtt gggttaccac ctaccgctag      540

cagtggtcat gggtatcagt gtcatgtctg ttctgcagtc ctgttcagtc ctttagacct      600

agacgcccac gtcgcatcac atggtttaca tggtaatatg acgttgacgt cgagtgagat      660

tcagcgacat atcactgagt ttattagttc atggcaaaat catcctattg ttcaagtttc      720

ggctgacgtc gaaaataaga agactgctca gttgcttcac gctgatactc ctcgacttgt      780

cacttgggat gctggtctgt gtacttcgtt caaaatcgtc ccaattgtac cagctcaggt      840

gccgcaggat gtactggcct atacgttctt cacctcttca tatgctattc aatcaccgtt      900

tccagaggcg gcggtgtcta ggattgtggt gcatacaaga tgggcatcta atgttgactt      960

tgaccgagat tcatctgtca tcatggcacc acctacagaa aataatatcc acttgtttaa     1020

gcagttgctg aatactgata ccctgtctgt gaggggggcc aacccactaa tgtttagggc     1080

gaacgtattg catatgttgc tggagttcgt attggataac ttgtatttga acagacatac     1140

gggattctct caagaccaca caccattcac tgagggcgct aatctgcgtt cacttcctgg     1200

ccccgatgct gagaaatggt attcgatcat gtatcccacg cgcatgggaa cgccgaatgt     1260

atcgaaaata tgtaatttcg tcgcctcttg tgtgcgaaat cgagtaggaa ggtttgatcg     1320

agcacagatg atgaacggag ccatgtcaga gtgggtggat gtcttcgaga cttcagacgc     1380

gcttaccgtc tccattcggg gtcgatggat ggctagactg gctcgcatga acataaatcc     1440

gacagagatc gaatgggcgt tgactgaatg tgcacaagga tatgtgactg ttacaagtcc     1500

ttacgctcct agcgtaaata gattgatgcc atatcgtatt tccaacgctg agcggcagat     1560

atcacagata atcaggatca tgaacattgg caataatgcc acggtgatac aacccgtcct     1620

acaagatatt tcggtactcc ttcaacgcat atcaccactc caaatagatc caaccattat     1680

ttctaacact atgtcaacag tctcggagtc tactactcag acactcagcc ccgcgtcctc     1740

aattttgggt aaactacgac cgagtaactc agatttctct agttttagag tcgcgttggc     1800

tgggtggctt tataatggag ttgtgacgac ggtgatcgat gatagttcat atccaaagga     1860

cggtggcagc gtgacctcac ttgaaaatct gtgggatttt ttcatccttg cgcttgctct     1920

accactgaca actgacccat gtgcacctgt gaaagcgttc atgactttag ctaacatgat     1980

ggtcggtttc gagacgatcc ccatggataa tcagatctat actcaatcga gacgcgcgag     2040

tgctttctca acgcctcaca cgtggccacg atgtttcatg aatatccagt taatttctcc     2100

catcgatgct cccatattac gacagtgggc tgaaattatt catagatact ggcctaatcc     2160

ttcacagatt cgttatggtg caccgaacgt ctttggctcg gcaaatctgt tcactccacc     2220

tgaggtgctg ttattgccaa tcgatcatca accagctaat gtgacaacgc caacgctgga     2280

cttcaccaac gaattgacta attggcgtgt tcgcgtttgt gagcttatga agaatcttgt     2340

tgataatcaa agatatcaac ctggatggac acaaagtcta gtctcgtcaa tgcgcggaac     2400

gctggacaaa ctgaaattga tcaaatcgat gacaccaatg tatctgcaac agctggctcc     2460

ggtagagtta gcagtgatag cccccatgtt gccttttcca cctttccaag tgccttacgt     2520

ccgccttgat cgtgatagag ttccaacaat ggtcggagtg acacgacagt cacgagatac     2580

tatcactcag ccagcgctat cattgtcaac aaccaatacc actgttggtg tgcctctagc     2640

tctagacgca agggctatta ccgttgcgct gttgtcaggg aaatatccgc cggatttggt     2700

gacaaatgta tggtacgctg atgccattta tccaatgtat gcagatactg aggtgttctc     2760

taatcttcag agagacatga ttacctgcga agccgtgcag acattagtga ctctggtggc     2820

gcagatatca gagacccagt atcctgtaga taggtatctt gattggatcc catcactgag     2880

agcatcggcg gcgacggcgg cgacatttgc tgagtgggtt aatacttcaa tgaagacggc     2940

gtttgatttg tctgacatgc tgttagaacc tctcctaagc ggagatccga ggatgactca     3000

actagcgatt cagtatcagc aatacaatgg cagaacgttt aatgtcatac ctgaaatgcc     3060

aggttcagtc attgctgact gtgttcaact aacagcagaa gtctttaatc acgaatataa     3120

cctgtttggg attgcgaggg gtgatatcat cattggtcgt gtccagtcga cacacttgtg     3180

gtcaccactg gctcctccac ctgacctggt gttcgatcgt gatactcctg gcgttcacat     3240

cttcggacga gattgccgta tatcgtttgg aatgaatggc gccgcgccaa tgattagaga     3300

tgagactgga atgatggtgc ctttcgaagg aaattggatt tttccactgg cgctttggca     3360

aatgaataca cgatatttta atcaacagtt cgacgcgtgg attaagacag gagagttgcg     3420

aatccgtatt gagatgggcg cgtatccata tatgttgcat tactatgatc cacgtcagta     3480

cgctaatgca tggaatttga catccgcctg gcttgaagaa attacaccga cgagcattcc     3540

atccgtgcct ttcatggtac caatttcaag tgatcatgac atttcctctg ccccagctgt     3600

ccaatatatc atttcgactg aatataatga tcggtcttta ttctgcacta actcatcatc     3660

tccccaaacc atcgctggac cagacaaaca cattccagtt gaaagatata acattctgac     3720

caaccccgat gctccaccca cgcagataca actgcctgaa gttattgact tgtataacgt     3780

cgtcacacgc tatgcgtatg agactccacc tattaccgct gttgttatgg gtgttccttg     3840

atcctcatcc tcccaacagg tgctagagca tcgcgctcga tgctagttgg gccgattcat     3900

c                                                                     3901


<210>  12
<211>  1275
<212>  PRT
<213>  orthoreovirus

<400>  12

Met Lys Arg Ile Pro Arg Lys Thr Lys Gly Lys Ser Ser Gly Lys Gly 
1               5                   10                  15      


Asn Asp Ser Thr Asp Arg Ala Asp Asp Gly Ser Ser Gln Leu Arg Asp 
            20                  25                  30          


Lys Gln Asn Asn Lys Thr Gly Pro Ala Thr Ala Glu Pro Gly Thr Ser 
        35                  40                  45              


Asn Arg Glu Arg Tyr Lys Ala Arg Pro Ser Ile Ala Ser Val Gln Arg 
    50                  55                  60                  


Ala Thr Glu Ser Ala Glu Leu Pro Ile Lys Asn Asn Asp Glu Gly Thr 
65                  70                  75                  80  


Pro Asp Lys Lys Gly Asn Thr Lys Gly Asp Leu Val Gly Gly His Ser 
                85                  90                  95      


Glu Ala Lys Asp Glu Ala Asp Glu Ala Thr Lys Lys Gln Ala Lys Asp 
            100                 105                 110         


Thr Asp Lys Ser Lys Ala Gln Val Thr Tyr Ser Asp Thr Gly Ile Asn 
        115                 120                 125             


Asn Ala Asn Glu Leu Ser Arg Ser Gly Asn Val Asp Asn Glu Gly Gly 
    130                 135                 140                 


Ser Asn Gln Lys Pro Met Ser Thr Arg Ile Ala Glu Ala Thr Ser Ala 
145                 150                 155                 160 


Ile Val Ser Lys His Pro Ala Arg Val Gly Leu Pro Pro Thr Ala Ser 
                165                 170                 175     


Ser Gly His Gly Tyr Gln Cys His Val Cys Ser Ala Val Leu Phe Ser 
            180                 185                 190         


Pro Leu Asp Leu Asp Ala His Val Ala Ser His Gly Leu His Gly Asn 
        195                 200                 205             


Met Thr Leu Thr Ser Ser Glu Ile Gln Arg His Ile Thr Glu Phe Ile 
    210                 215                 220                 


Ser Ser Trp Gln Asn His Pro Ile Val Gln Val Ser Ala Asp Val Glu 
225                 230                 235                 240 


Asn Lys Lys Thr Ala Gln Leu Leu His Ala Asp Thr Pro Arg Leu Val 
                245                 250                 255     


Thr Trp Asp Ala Gly Leu Cys Thr Ser Phe Lys Ile Val Pro Ile Val 
            260                 265                 270         


Pro Ala Gln Val Pro Gln Asp Val Leu Ala Tyr Thr Phe Phe Thr Ser 
        275                 280                 285             


Ser Tyr Ala Ile Gln Ser Pro Phe Pro Glu Ala Ala Val Ser Arg Ile 
    290                 295                 300                 


Val Val His Thr Arg Trp Ala Ser Asn Val Asp Phe Asp Arg Asp Ser 
305                 310                 315                 320 


Ser Val Ile Met Ala Pro Pro Thr Glu Asn Asn Ile His Leu Phe Lys 
                325                 330                 335     


Gln Leu Leu Asn Thr Asp Thr Leu Ser Val Arg Gly Ala Asn Pro Leu 
            340                 345                 350         


Met Phe Arg Ala Asn Val Leu His Met Leu Leu Glu Phe Val Leu Asp 
        355                 360                 365             


Asn Leu Tyr Leu Asn Arg His Thr Gly Phe Ser Gln Asp His Thr Pro 
    370                 375                 380                 


Phe Thr Glu Gly Ala Asn Leu Arg Ser Leu Pro Gly Pro Asp Ala Glu 
385                 390                 395                 400 


Lys Trp Tyr Ser Ile Met Tyr Pro Thr Arg Met Gly Thr Pro Asn Val 
                405                 410                 415     


Ser Lys Ile Cys Asn Phe Val Ala Ser Cys Val Arg Asn Arg Val Gly 
            420                 425                 430         


Arg Phe Asp Arg Ala Gln Met Met Asn Gly Ala Met Ser Glu Trp Val 
        435                 440                 445             


Asp Val Phe Glu Thr Ser Asp Ala Leu Thr Val Ser Ile Arg Gly Arg 
    450                 455                 460                 


Trp Met Ala Arg Leu Ala Arg Met Asn Ile Asn Pro Thr Glu Ile Glu 
465                 470                 475                 480 


Trp Ala Leu Thr Glu Cys Ala Gln Gly Tyr Val Thr Val Thr Ser Pro 
                485                 490                 495     


Tyr Ala Pro Ser Val Asn Arg Leu Met Pro Tyr Arg Ile Ser Asn Ala 
            500                 505                 510         


Glu Arg Gln Ile Ser Gln Ile Ile Arg Ile Met Asn Ile Gly Asn Asn 
        515                 520                 525             


Ala Thr Val Ile Gln Pro Val Leu Gln Asp Ile Ser Val Leu Leu Gln 
    530                 535                 540                 


Arg Ile Ser Pro Leu Gln Ile Asp Pro Thr Ile Ile Ser Asn Thr Met 
545                 550                 555                 560 


Ser Thr Val Ser Glu Ser Thr Thr Gln Thr Leu Ser Pro Ala Ser Ser 
                565                 570                 575     


Ile Leu Gly Lys Leu Arg Pro Ser Asn Ser Asp Phe Ser Ser Phe Arg 
            580                 585                 590         


Val Ala Leu Ala Gly Trp Leu Tyr Asn Gly Val Val Thr Thr Val Ile 
        595                 600                 605             


Asp Asp Ser Ser Tyr Pro Lys Asp Gly Gly Ser Val Thr Ser Leu Glu 
    610                 615                 620                 


Asn Leu Trp Asp Phe Phe Ile Leu Ala Leu Ala Leu Pro Leu Thr Thr 
625                 630                 635                 640 


Asp Pro Cys Ala Pro Val Lys Ala Phe Met Thr Leu Ala Asn Met Met 
                645                 650                 655     


Val Gly Phe Glu Thr Ile Pro Met Asp Asn Gln Ile Tyr Thr Gln Ser 
            660                 665                 670         


Arg Arg Ala Ser Ala Phe Ser Thr Pro His Thr Trp Pro Arg Cys Phe 
        675                 680                 685             


Met Asn Ile Gln Leu Ile Ser Pro Ile Asp Ala Pro Ile Leu Arg Gln 
    690                 695                 700                 


Trp Ala Glu Ile Ile His Arg Tyr Trp Pro Asn Pro Ser Gln Ile Arg 
705                 710                 715                 720 


Tyr Gly Ala Pro Asn Val Phe Gly Ser Ala Asn Leu Phe Thr Pro Pro 
                725                 730                 735     


Glu Val Leu Leu Leu Pro Ile Asp His Gln Pro Ala Asn Val Thr Thr 
            740                 745                 750         


Pro Thr Leu Asp Phe Thr Asn Glu Leu Thr Asn Trp Arg Val Arg Val 
        755                 760                 765             


Cys Glu Leu Met Lys Asn Leu Val Asp Asn Gln Arg Tyr Gln Pro Gly 
    770                 775                 780                 


Trp Thr Gln Ser Leu Val Ser Ser Met Arg Gly Thr Leu Asp Lys Leu 
785                 790                 795                 800 


Lys Leu Ile Lys Ser Met Thr Pro Met Tyr Leu Gln Gln Leu Ala Pro 
                805                 810                 815     


Val Glu Leu Ala Val Ile Ala Pro Met Leu Pro Phe Pro Pro Phe Gln 
            820                 825                 830         


Val Pro Tyr Val Arg Leu Asp Arg Asp Arg Val Pro Thr Met Val Gly 
        835                 840                 845             


Val Thr Arg Gln Ser Arg Asp Thr Ile Thr Gln Pro Ala Leu Ser Leu 
    850                 855                 860                 


Ser Thr Thr Asn Thr Thr Val Gly Val Pro Leu Ala Leu Asp Ala Arg 
865                 870                 875                 880 


Ala Ile Thr Val Ala Leu Leu Ser Gly Lys Tyr Pro Pro Asp Leu Val 
                885                 890                 895     


Thr Asn Val Trp Tyr Ala Asp Ala Ile Tyr Pro Met Tyr Ala Asp Thr 
            900                 905                 910         


Glu Val Phe Ser Asn Leu Gln Arg Asp Met Ile Thr Cys Glu Ala Val 
        915                 920                 925             


Gln Thr Leu Val Thr Leu Val Ala Gln Ile Ser Glu Thr Gln Tyr Pro 
    930                 935                 940                 


Val Asp Arg Tyr Leu Asp Trp Ile Pro Ser Leu Arg Ala Ser Ala Ala 
945                 950                 955                 960 


Thr Ala Ala Thr Phe Ala Glu Trp Val Asn Thr Ser Met Lys Thr Ala 
                965                 970                 975     


Phe Asp Leu Ser Asp Met Leu Leu Glu Pro Leu Leu Ser Gly Asp Pro 
            980                 985                 990         


Arg Met Thr Gln Leu Ala Ile Gln  Tyr Gln Gln Tyr Asn  Gly Arg Thr 
        995                 1000                 1005             


Phe Asn  Val Ile Pro Glu Met  Pro Gly Ser Val Ile  Ala Asp Cys 
    1010                 1015                 1020             


Val Gln  Leu Thr Ala Glu Val  Phe Asn His Glu Tyr  Asn Leu Phe 
    1025                 1030                 1035             


Gly Ile  Ala Arg Gly Asp Ile  Ile Ile Gly Arg Val  Gln Ser Thr 
    1040                 1045                 1050             


His Leu  Trp Ser Pro Leu Ala  Pro Pro Pro Asp Leu  Val Phe Asp 
    1055                 1060                 1065             


Arg Asp  Thr Pro Gly Val His  Ile Phe Gly Arg Asp  Cys Arg Ile 
    1070                 1075                 1080             


Ser Phe  Gly Met Asn Gly Ala  Ala Pro Met Ile Arg  Asp Glu Thr 
    1085                 1090                 1095             


Gly Met  Met Val Pro Phe Glu  Gly Asn Trp Ile Phe  Pro Leu Ala 
    1100                 1105                 1110             


Leu Trp  Gln Met Asn Thr Arg  Tyr Phe Asn Gln Gln  Phe Asp Ala 
    1115                 1120                 1125             


Trp Ile  Lys Thr Gly Glu Leu  Arg Ile Arg Ile Glu  Met Gly Ala 
    1130                 1135                 1140             


Tyr Pro  Tyr Met Leu His Tyr  Tyr Asp Pro Arg Gln  Tyr Ala Asn 
    1145                 1150                 1155             


Ala Trp  Asn Leu Thr Ser Ala  Trp Leu Glu Glu Ile  Thr Pro Thr 
    1160                 1165                 1170             


Ser Ile  Pro Ser Val Pro Phe  Met Val Pro Ile Ser  Ser Asp His 
    1175                 1180                 1185             


Asp Ile  Ser Ser Ala Pro Ala  Val Gln Tyr Ile Ile  Ser Thr Glu 
    1190                 1195                 1200             


Tyr Asn  Asp Arg Ser Leu Phe  Cys Thr Asn Ser Ser  Ser Pro Gln 
    1205                 1210                 1215             


Thr Ile  Ala Gly Pro Asp Lys  His Ile Pro Val Glu  Arg Tyr Asn 
    1220                 1225                 1230             


Ile Leu  Thr Asn Pro Asp Ala  Pro Pro Thr Gln Ile  Gln Leu Pro 
    1235                 1240                 1245             


Glu Val  Ile Asp Leu Tyr Asn  Val Val Thr Arg Tyr  Ala Tyr Glu 
    1250                 1255                 1260             


Thr Pro  Pro Ile Thr Ala Val  Val Met Gly Val Pro  
    1265                 1270                 1275 


<210>  13
<211>  2304
<212>  DNA
<213>  orthoreovirus

<400>  13
gctattcgcg gtcatggctt acatcgcagt tcctgcggtg gtggattcac gttcgagtga       60

ggctattgga ctactagaat cgtttggagt agacgctggg gctgatgtga atgatgtttc      120

atatcaagat catgactatg tgttggatca gttacagtat atgttagatg ggtatgaggc      180

tggtgacgtc atcgatgcac tcgtccacaa gaattggtta catcattctg tctattgctt      240

gttgccaccc aaaagtcaac tactagagta ttggaaaagt aacccttcag cgataccgga      300

caacgttgat cgtcggcttc gtaaacggct aatgctaaag aaagatctca gaaaagatga      360

tgagtacaat caattggcgc gtgctttcaa gatatcggat gtctacgcac cactcatctc      420

atctacgacg tcaccgatga caatgatcca gaacttgaat cagggcgaga tcgtgtacac      480

cacgacggac agagtaattg gggctagaat cttgttatat gctccaagaa agtactatgc      540

atcaactcta tcatttacta tgactaagtg catcattccg tttggcaaag aggtgggccg      600

tgctcctcac tctagattta atgttggcac attcccatca attgctactc cgaagtgttt      660

tgttatgagt ggggttgata ttgagtccat cccaaatgaa tttatcaaat tgttttacca      720

gcgcgtcaag agtgttcacg ctaatatact aaatgacata tcacctcaga tactctctga      780

catgataaac agaaagcgtt tgcgtgttca tactccatca gatcgtcgag ccgcgcaact      840

gatgcatttg ccctatcatg ttaagcgagg ggcgtctcac gtcgacgttt ataaggtaga      900

tgttgtggat gtattgtttg aggtagtaga tgtggccgat gggttgcgca atgtatctag      960

gaagctaact atgcacactg ttccggtctg tattcttgaa atgttgggta ttgagattgc     1020

ggactattgc gttcgtcgag aggatggaat gttcacagat tggttcttgc ttttaaccat     1080

gctatctgat ggcttaactg atagaaggac gcgttgtcaa tacctgatta atccgtcaag     1140

cgtgcctcct gatgtaatac ttaacatctc tattactgga tttataaaca ggcatacaat     1200

cgacgtcatg cctgacacat acgacttcat taaacccatt ggtgctgtgc tgcctaaggg     1260

atcattcaaa tcgacaatta tgagagttct tgactcaata tcaatattag gagttcagat     1320

catgccgcgc acgcatgtag tcgactcgga tgaggtgggc gagcaaatgg agcctacgtt     1380

tgagcatgcg gtcatggaga tatacagagg aattgctggc gttgactctc tggatgatct     1440

cattaggtgg gtgctgaact cggatctcat tccatatgat gacaggcttg gccaattatt     1500

tcaagcgttt ctgcctctcg caaaagattt gttagcgcca atggccagaa agttttatga     1560

taactcaatg agtgagggta gattgctgac attcgctcat gctgatagtg agttgctgaa     1620

cgcaaattac tttggtcatt tactgcgact aaaaatacca tatattacag aggttaattt     1680

gatgattcgc aagaatcgtg agggtgggga gctatttcag cttgtgttat cacatctata     1740

taaaatgtat gctactagcg cgcagcctaa atggtttgga tcattattgc gattgttaat     1800

atgtccctgg ttacatatgg agaaattgat aggagaagca gacccagcat ctacgtcggc     1860

tgaaattgga tggtatatct ctcgtgaaca gctgatgcaa gatggatggt gtggatgtga     1920

agatggattc attccctata ttagcatacg tgcgccaaag ctggttatag aggagttaat     1980

ggagaagaat tggggccaat atcatgcaca agttattatc actgatcggc ttgtcgtagg     2040

cgaaccgcgt agggtatctg ccaaggctgt ggtcaaaggt aaccacttac cagttaagtt     2100

agtctcacga tttgcatgtt tcacactgac gacgaagtat gagatgaggc tttcatgtgg     2160

ccatagcact ggacgggggg ctgcatacaa tgcgagacta gttttccgat ctgacttggc     2220

gtgatccgtg acatgcgtag tgtgacacct gcccctaggt caatgggggt agggggcggg     2280

ctaggactac gtacgcgctt catc                                            2304


<210>  14
<211>  736
<212>  PRT
<213>  orthoreovirus

<400>  14

Met Ala Tyr Ile Ala Val Pro Ala Val Val Asp Ser Arg Ser Ser Glu 
1               5                   10                  15      


Ala Ile Gly Leu Leu Glu Ser Phe Gly Val Asp Ala Gly Ala Asp Val 
            20                  25                  30          


Asn Asp Val Ser Tyr Gln Asp His Asp Tyr Val Leu Asp Gln Leu Gln 
        35                  40                  45              


Tyr Met Leu Asp Gly Tyr Glu Ala Gly Asp Val Ile Asp Ala Leu Val 
    50                  55                  60                  


His Lys Asn Trp Leu His His Ser Val Tyr Cys Leu Leu Pro Pro Lys 
65                  70                  75                  80  


Ser Gln Leu Leu Glu Tyr Trp Lys Ser Asn Pro Ser Ala Ile Pro Asp 
                85                  90                  95      


Asn Val Asp Arg Arg Leu Arg Lys Arg Leu Met Leu Lys Lys Asp Leu 
            100                 105                 110         


Arg Lys Asp Asp Glu Tyr Asn Gln Leu Ala Arg Ala Phe Lys Ile Ser 
        115                 120                 125             


Asp Val Tyr Ala Pro Leu Ile Ser Ser Thr Thr Ser Pro Met Thr Met 
    130                 135                 140                 


Ile Gln Asn Leu Asn Gln Gly Glu Ile Val Tyr Thr Thr Thr Asp Arg 
145                 150                 155                 160 


Val Ile Gly Ala Arg Ile Leu Leu Tyr Ala Pro Arg Lys Tyr Tyr Ala 
                165                 170                 175     


Ser Thr Leu Ser Phe Thr Met Thr Lys Cys Ile Ile Pro Phe Gly Lys 
            180                 185                 190         


Glu Val Gly Arg Ala Pro His Ser Arg Phe Asn Val Gly Thr Phe Pro 
        195                 200                 205             


Ser Ile Ala Thr Pro Lys Cys Phe Val Met Ser Gly Val Asp Ile Glu 
    210                 215                 220                 


Ser Ile Pro Asn Glu Phe Ile Lys Leu Phe Tyr Gln Arg Val Lys Ser 
225                 230                 235                 240 


Val His Ala Asn Ile Leu Asn Asp Ile Ser Pro Gln Ile Leu Ser Asp 
                245                 250                 255     


Met Ile Asn Arg Lys Arg Leu Arg Val His Thr Pro Ser Asp Arg Arg 
            260                 265                 270         


Ala Ala Gln Leu Met His Leu Pro Tyr His Val Lys Arg Gly Ala Ser 
        275                 280                 285             


His Val Asp Val Tyr Lys Val Asp Val Val Asp Val Leu Phe Glu Val 
    290                 295                 300                 


Val Asp Val Ala Asp Gly Leu Arg Asn Val Ser Arg Lys Leu Thr Met 
305                 310                 315                 320 


His Thr Val Pro Val Cys Ile Leu Glu Met Leu Gly Ile Glu Ile Ala 
                325                 330                 335     


Asp Tyr Cys Val Arg Arg Glu Asp Gly Met Phe Thr Asp Trp Phe Leu 
            340                 345                 350         


Leu Leu Thr Met Leu Ser Asp Gly Leu Thr Asp Arg Arg Thr Arg Cys 
        355                 360                 365             


Gln Tyr Leu Ile Asn Pro Ser Ser Val Pro Pro Asp Val Ile Leu Asn 
    370                 375                 380                 


Ile Ser Ile Thr Gly Phe Ile Asn Arg His Thr Ile Asp Val Met Pro 
385                 390                 395                 400 


Asp Thr Tyr Asp Phe Ile Lys Pro Ile Gly Ala Val Leu Pro Lys Gly 
                405                 410                 415     


Ser Phe Lys Ser Thr Ile Met Arg Val Leu Asp Ser Ile Ser Ile Leu 
            420                 425                 430         


Gly Val Gln Ile Met Pro Arg Thr His Val Val Asp Ser Asp Glu Val 
        435                 440                 445             


Gly Glu Gln Met Glu Pro Thr Phe Glu His Ala Val Met Glu Ile Tyr 
    450                 455                 460                 


Arg Gly Ile Ala Gly Val Asp Ser Leu Asp Asp Leu Ile Arg Trp Val 
465                 470                 475                 480 


Leu Asn Ser Asp Leu Ile Pro Tyr Asp Asp Arg Leu Gly Gln Leu Phe 
                485                 490                 495     


Gln Ala Phe Leu Pro Leu Ala Lys Asp Leu Leu Ala Pro Met Ala Arg 
            500                 505                 510         


Lys Phe Tyr Asp Asn Ser Met Ser Glu Gly Arg Leu Leu Thr Phe Ala 
        515                 520                 525             


His Ala Asp Ser Glu Leu Leu Asn Ala Asn Tyr Phe Gly His Leu Leu 
    530                 535                 540                 


Arg Leu Lys Ile Pro Tyr Ile Thr Glu Val Asn Leu Met Ile Arg Lys 
545                 550                 555                 560 


Asn Arg Glu Gly Gly Glu Leu Phe Gln Leu Val Leu Ser His Leu Tyr 
                565                 570                 575     


Lys Met Tyr Ala Thr Ser Ala Gln Pro Lys Trp Phe Gly Ser Leu Leu 
            580                 585                 590         


Arg Leu Leu Ile Cys Pro Trp Leu His Met Glu Lys Leu Ile Gly Glu 
        595                 600                 605             


Ala Asp Pro Ala Ser Thr Ser Ala Glu Ile Gly Trp Tyr Ile Ser Arg 
    610                 615                 620                 


Glu Gln Leu Met Gln Asp Gly Trp Cys Gly Cys Glu Asp Gly Phe Ile 
625                 630                 635                 640 


Pro Tyr Ile Ser Ile Arg Ala Pro Lys Leu Val Ile Glu Glu Leu Met 
                645                 650                 655     


Glu Lys Asn Trp Gly Gln Tyr His Ala Gln Val Ile Ile Thr Asp Arg 
            660                 665                 670         


Leu Val Val Gly Glu Pro Arg Arg Val Ser Ala Lys Ala Val Val Lys 
        675                 680                 685             


Gly Asn His Leu Pro Val Lys Leu Val Ser Arg Phe Ala Cys Phe Thr 
    690                 695                 700                 


Leu Thr Thr Lys Tyr Glu Met Arg Leu Ser Cys Gly His Ser Thr Gly 
705                 710                 715                 720 


Arg Gly Ala Ala Tyr Asn Ala Arg Leu Val Phe Arg Ser Asp Leu Ala 
                725                 730                 735     


<210>  15
<211>  2205
<212>  DNA
<213>  orthoreovirus

<400>  15
tgctaatctg ctgaccgtta ctctgcaaag atggggaacg cttcctctat tgttcagacg       60

atcaacgtca ctggagatgg caatgtgttc aaaccctcag ctgagacttc atccaccgct      120

gtaccgtcac taagtctatc acctggaatg ctaaatcctg gaggagtacc atggatcgcg      180

attggggatg agacatctgt tacttcaccg ggtgcgttgc ggcgaatgac ttcgaaggat      240

attccagaaa cagcgataat caacacagat aattcatcag gcgcggtgcc aagtgaatca      300

gcgttggtgc cttacaatga tgagccattg gtggtggtga cggagcatgc tatcgcaaac      360

tttactaaag ctgagatggc acttgaattc aatcgtgagt ttcttgataa attgcgcgta      420

ctgtcagtgt caccgaaata ttctgacctt ctaacgtatg ttgattgcta cgttggtgtg      480

tcggctcgtc aagccctaaa caatttccag aaacaggtac ctgtgattac acctactaga      540

caaacaatgt atgttgactc catacaggcg gccttgaaag cccttgagaa atgggaaatt      600

gatttgagag tggctcagac gctgttgcct acaaatgtcc caattgggga ggtttcttgt      660

ccaatgcagt cagtagtgaa actattagat gatcagctgc ccgacgatag ccttatacga      720

aggtatccta aggaggctgc tgttgctttg gccaaaagga acgggggaat acagtggatg      780

gatgtgtcag aaggtactgt gatgaacgag gccgtaaatg ctgttgcagc aagtgccctg      840

gcaccttccg cctcatcccc gcccctggaa gagaaatcaa aattgactga gcaagcgatg      900

gatcttgtaa ccgcagctga acctgagata gtcgcctctc tcgtgccagt tccagcgccc      960

gtgtttgcca ttccacctaa gccagccgat tataacgtgc gtaccctgaa gatcgatgag     1020

gccacatggt tgcgaatgat tccaaaaact atgagtacgc ctttccaaat tcaagtgact     1080

gataatacag gaactaaatg gcatcttaac ttgagaggag ggacacgcgt agtgaatctg     1140

gaccagattg ctccgatgag gttcgttctg gatctagggg gaaagagtta caaggagacg     1200

agttgggatc caaacggtaa gaaggttggg tttatcgtat tccagtctaa gattcctttt     1260

gagctttgga ccgctgcatc acagattggt caagccacag tggtcaacta tgttcagcta     1320

tatgctgaag acagctcatt taccgcccag tctattatcg ctactacatc gttggcttat     1380

aattatgaac cagagcaatt gaataagact gaccctgagg tgaactatta ccttctagcg     1440

acttttatag attcagctgc tataacaccg acgaacatga cacagcctga tgtttgggat     1500

gctatgttga cgatgtctcc attgtccgct ggggaggtga ctgtgaaggg tgcggtggta     1560

agcgaggtgg tgccagcgga attgatcggc agctatactc cagagtcatt aaatgcctca     1620

cttccgaatg acgctgctag atgtatgatt gatagagcct cgaaaatagc cgaagctata     1680

aagattgatg atgacgctgg gccagatgaa tactctccca actctgtacc aattcaaggt     1740

cagttggcta tttctcaact tgagactggg tatggtgtac ggatattcaa ttctaaggga     1800

attctttcga aaatcgcgtc cagagctatg caggctttta tcggtgatcc aagcacaatt     1860

atcacgcagg cggcaccagt gctgtcagat aagaacaatt ggattgcatt ggcacaagga     1920

gtcaagacta gtttgcgtac caaaagtcta tcagcggggg tgaagacggc ggtgagtaaa     1980

ctgagctcgt ccgagtctat tcagagttgg actcaaggat tcttggataa agtatcgatg     2040

cattttccag cgcctaagtc ggactgtccg accagcggag atagcagtga atcgtccgct     2100

cggcgagtga agcgcgactc atacgcagga gtggttaagc gtgggtatac acgttaagcc     2160

gctcgccctg gtgacgcggg gttaagggat gcaggcacat catca                     2205


<210>  16
<211>  708
<212>  PRT
<213>  orthoreovirus

<400>  16

Met Gly Asn Ala Ser Ser Ile Val Gln Thr Ile Asn Val Thr Gly Asp 
1               5                   10                  15      


Gly Asn Val Phe Lys Pro Ser Ala Glu Thr Ser Ser Thr Ala Val Pro 
            20                  25                  30          


Ser Leu Ser Leu Ser Pro Gly Met Leu Asn Pro Gly Gly Val Pro Trp 
        35                  40                  45              


Ile Ala Ile Gly Asp Glu Thr Ser Val Thr Ser Pro Gly Ala Leu Arg 
    50                  55                  60                  


Arg Met Thr Ser Lys Asp Ile Pro Glu Thr Ala Ile Ile Asn Thr Asp 
65                  70                  75                  80  


Asn Ser Ser Gly Ala Val Pro Ser Glu Ser Ala Leu Val Pro Tyr Asn 
                85                  90                  95      


Asp Glu Pro Leu Val Val Val Thr Glu His Ala Ile Ala Asn Phe Thr 
            100                 105                 110         


Lys Ala Glu Met Ala Leu Glu Phe Asn Arg Glu Phe Leu Asp Lys Leu 
        115                 120                 125             


Arg Val Leu Ser Val Ser Pro Lys Tyr Ser Asp Leu Leu Thr Tyr Val 
    130                 135                 140                 


Asp Cys Tyr Val Gly Val Ser Ala Arg Gln Ala Leu Asn Asn Phe Gln 
145                 150                 155                 160 


Lys Gln Val Pro Val Ile Thr Pro Thr Arg Gln Thr Met Tyr Val Asp 
                165                 170                 175     


Ser Ile Gln Ala Ala Leu Lys Ala Leu Glu Lys Trp Glu Ile Asp Leu 
            180                 185                 190         


Arg Val Ala Gln Thr Leu Leu Pro Thr Asn Val Pro Ile Gly Glu Val 
        195                 200                 205             


Ser Cys Pro Met Gln Ser Val Val Lys Leu Leu Asp Asp Gln Leu Pro 
    210                 215                 220                 


Asp Asp Ser Leu Ile Arg Arg Tyr Pro Lys Glu Ala Ala Val Ala Leu 
225                 230                 235                 240 


Ala Lys Arg Asn Gly Gly Ile Gln Trp Met Asp Val Ser Glu Gly Thr 
                245                 250                 255     


Val Met Asn Glu Ala Val Asn Ala Val Ala Ala Ser Ala Leu Ala Pro 
            260                 265                 270         


Ser Ala Ser Ser Pro Pro Leu Glu Glu Lys Ser Lys Leu Thr Glu Gln 
        275                 280                 285             


Ala Met Asp Leu Val Thr Ala Ala Glu Pro Glu Ile Val Ala Ser Leu 
    290                 295                 300                 


Val Pro Val Pro Ala Pro Val Phe Ala Ile Pro Pro Lys Pro Ala Asp 
305                 310                 315                 320 


Tyr Asn Val Arg Thr Leu Lys Ile Asp Glu Ala Thr Trp Leu Arg Met 
                325                 330                 335     


Ile Pro Lys Thr Met Ser Thr Pro Phe Gln Ile Gln Val Thr Asp Asn 
            340                 345                 350         


Thr Gly Thr Lys Trp His Leu Asn Leu Arg Gly Gly Thr Arg Val Val 
        355                 360                 365             


Asn Leu Asp Gln Ile Ala Pro Met Arg Phe Val Leu Asp Leu Gly Gly 
    370                 375                 380                 


Lys Ser Tyr Lys Glu Thr Ser Trp Asp Pro Asn Gly Lys Lys Val Gly 
385                 390                 395                 400 


Phe Ile Val Phe Gln Ser Lys Ile Pro Phe Glu Leu Trp Thr Ala Ala 
                405                 410                 415     


Ser Gln Ile Gly Gln Ala Thr Val Val Asn Tyr Val Gln Leu Tyr Ala 
            420                 425                 430         


Glu Asp Ser Ser Phe Thr Ala Gln Ser Ile Ile Ala Thr Thr Ser Leu 
        435                 440                 445             


Ala Tyr Asn Tyr Glu Pro Glu Gln Leu Asn Lys Thr Asp Pro Glu Val 
    450                 455                 460                 


Asn Tyr Tyr Leu Leu Ala Thr Phe Ile Asp Ser Ala Ala Ile Thr Pro 
465                 470                 475                 480 


Thr Asn Met Thr Gln Pro Asp Val Trp Asp Ala Met Leu Thr Met Ser 
                485                 490                 495     


Pro Leu Ser Ala Gly Glu Val Thr Val Lys Gly Ala Val Val Ser Glu 
            500                 505                 510         


Val Val Pro Ala Glu Leu Ile Gly Ser Tyr Thr Pro Glu Ser Leu Asn 
        515                 520                 525             


Ala Ser Leu Pro Asn Asp Ala Ala Arg Cys Met Ile Asp Arg Ala Ser 
    530                 535                 540                 


Lys Ile Ala Glu Ala Ile Lys Ile Asp Asp Asp Ala Gly Pro Asp Glu 
545                 550                 555                 560 


Tyr Ser Pro Asn Ser Val Pro Ile Gln Gly Gln Leu Ala Ile Ser Gln 
                565                 570                 575     


Leu Glu Thr Gly Tyr Gly Val Arg Ile Phe Asn Ser Lys Gly Ile Leu 
            580                 585                 590         


Ser Lys Ile Ala Ser Arg Ala Met Gln Ala Phe Ile Gly Asp Pro Ser 
        595                 600                 605             


Thr Ile Ile Thr Gln Ala Ala Pro Val Leu Ser Asp Lys Asn Asn Trp 
    610                 615                 620                 


Ile Ala Leu Ala Gln Gly Val Lys Thr Ser Leu Arg Thr Lys Ser Leu 
625                 630                 635                 640 


Ser Ala Gly Val Lys Thr Ala Val Ser Lys Leu Ser Ser Ser Glu Ser 
                645                 650                 655     


Ile Gln Ser Trp Thr Gln Gly Phe Leu Asp Lys Val Ser Met His Phe 
            660                 665                 670         


Pro Ala Pro Lys Ser Asp Cys Pro Thr Ser Gly Asp Ser Ser Glu Ser 
        675                 680                 685             


Ser Ala Arg Arg Val Lys Arg Asp Ser Tyr Ala Gly Val Val Lys Arg 
    690                 695                 700                 


Gly Tyr Thr Arg 
705             


<210>  17
<211>  2241
<212>  DNA
<213>  orthoreovirus

<400>  17
gctaaagtga ccgtggtcat ggcttcgttc aagggattct ccgccaacac tgttccagtt       60

tccaaggcca aacgtgacat atcatccctt gctgctactc ctggatttca ttcacaatcc      120

tttactccgt ctgtggatat gtctcaatcg cgtgaattcc tcacaaaagc aatcgagcag      180

gggtccatgt ctatacctta tcagcatgtg aatgtaccga aagttgatcg taaagttgtc      240

agcttggtag tgcggccttt ttcttcaggt gctttctcta tctctggagt gatttcgcca      300

gcccatgcct atctgctaga ttgtctacct cagcttgagc aggcaatggc ttttgttgct      360

tcacccgagt ctttccaggc ttcagatgtt gcaaagcgtt ttgctataaa gccaggtatg      420

agcctccagg acgctatcac tgcgtttatt aatttcgtgt ccgcgatgct gaaaatgacg      480

gtgactcgtc agaattttga tgttattgta gctgagatcg agaggcttgc ttcaaccagc      540

gtgtctgtca ggactgagga agcgaaggtt gctgatgagg agctgatgtt attcgggcta      600

gatcacagag ggccacagca gttggatatt tctgacgcta aagggataac gaaggctgct      660

gacattcaga caactcatga tgttcatctg gcacccggcg ttggtaatat tgaccctgaa      720

atctataacg aagggcggtt catgttcatg cagcacaaac cacttgcggc ggatcaatcg      780

tactttacct tagagactgc ggattatttc aagatttatc caacatatga cgaacatgat      840

ggtaggatgg ctgaccaaaa gcagtcggga ttgatactat gtactaaaga tgaagtgttg      900

gctgagcaaa ctatatttaa actggacgct cccgacgaca aaactgttca tctgttagat      960

cgtgacgacg accacgttgt tgccagattt accaaggtat ttatagaaga cgtagctccc     1020

gggcatcacg ctgctcagag atcgggacaa cgctctgtgc ttgatgacct atatgcgaat     1080

acgcaagtga tttccattac ctccgccgct ctgaagtggg tggttaaaca tggcgtgtct     1140

gatggaattg tgaataggaa gaatgtcaaa gtgtgtgttg gttttgaccc tttatacact     1200

ctgtccacgc ataacggaat atctctgtgt gccctgttga tggatgagaa gctttcggtg     1260

ctgaacagtg cgtgtcgtat gacgttgcgc tctctcatga agaccggacg tgatgctgat     1320

gcacacagag cttttcagcg agtcctttct caaggatacg catcgttaat gtgctattat     1380

cacccttcac ggaagctggc atatggcgag gtgcttcttc cagaacggtc caatgacgtg     1440

gtagatggga tcaagctaca gttggacgca tccagacatt gtcatgaatg tcctgtgttg     1500

cagcagaaag tggttgaatt ggaaaaacag atcgtcatgc aaaagtcgat tcagtcagac     1560

cctaccccaa tggcactgca accactgttg tctcagttgc gtgagctatc cagcgaagtt     1620

actaggctgc agatggagtt gagtagggct caatctttga atgcccagtt ggaggcggat     1680

gtcaaatcag ctcaatcatg cagcctggat atgtatctga gacaccacac ttgcattaat     1740

ggtcatgcta aagaggatga attgcttgat gctgtgcgtg tcgcaccgga tgtgaggagg     1800

caaatcatgg aaaggaggag tgaagtgaga aagggatggt gtgaacgtat ttctaaggaa     1860

gcgtctgccg aatgtcagaa tgttattgat gatctgactc tgatgaatgg aaagcaggcc     1920

caagagataa gagaattacg tgattcggct gagagttatg agaaacagat tgcggagctg     1980

gtgagtacca tcacccaaaa ccagatgact tatcagcaag agttacaagc cttagtagcg     2040

aaaaacgtgg aattggatac attgaatcaa cgtcaggcta ggtcgttgcg gattactccc     2100

tctcttctat cagtcactcc taccgattca gttgatggcg ctgctgacct aatcgatttc     2160

tctgttccga ctgatgagct gtaaatgatc cgtgatgcag tgttgtccta atcccttaag     2220

ccttcccgac ccccattcat c                                               2241


<210>  18
<211>  721
<212>  PRT
<213>  orthoreovirus

<400>  18

Met Ala Ser Phe Lys Gly Phe Ser Ala Asn Thr Val Pro Val Ser Lys 
1               5                   10                  15      


Ala Lys Arg Asp Ile Ser Ser Leu Ala Ala Thr Pro Gly Phe His Ser 
            20                  25                  30          


Gln Ser Phe Thr Pro Ser Val Asp Met Ser Gln Ser Arg Glu Phe Leu 
        35                  40                  45              


Thr Lys Ala Ile Glu Gln Gly Ser Met Ser Ile Pro Tyr Gln His Val 
    50                  55                  60                  


Asn Val Pro Lys Val Asp Arg Lys Val Val Ser Leu Val Val Arg Pro 
65                  70                  75                  80  


Phe Ser Ser Gly Ala Phe Ser Ile Ser Gly Val Ile Ser Pro Ala His 
                85                  90                  95      


Ala Tyr Leu Leu Asp Cys Leu Pro Gln Leu Glu Gln Ala Met Ala Phe 
            100                 105                 110         


Val Ala Ser Pro Glu Ser Phe Gln Ala Ser Asp Val Ala Lys Arg Phe 
        115                 120                 125             


Ala Ile Lys Pro Gly Met Ser Leu Gln Asp Ala Ile Thr Ala Phe Ile 
    130                 135                 140                 


Asn Phe Val Ser Ala Met Leu Lys Met Thr Val Thr Arg Gln Asn Phe 
145                 150                 155                 160 


Asp Val Ile Val Ala Glu Ile Glu Arg Leu Ala Ser Thr Ser Val Ser 
                165                 170                 175     


Val Arg Thr Glu Glu Ala Lys Val Ala Asp Glu Glu Leu Met Leu Phe 
            180                 185                 190         


Gly Leu Asp His Arg Gly Pro Gln Gln Leu Asp Ile Ser Asp Ala Lys 
        195                 200                 205             


Gly Ile Thr Lys Ala Ala Asp Ile Gln Thr Thr His Asp Val His Leu 
    210                 215                 220                 


Ala Pro Gly Val Gly Asn Ile Asp Pro Glu Ile Tyr Asn Glu Gly Arg 
225                 230                 235                 240 


Phe Met Phe Met Gln His Lys Pro Leu Ala Ala Asp Gln Ser Tyr Phe 
                245                 250                 255     


Thr Leu Glu Thr Ala Asp Tyr Phe Lys Ile Tyr Pro Thr Tyr Asp Glu 
            260                 265                 270         


His Asp Gly Arg Met Ala Asp Gln Lys Gln Ser Gly Leu Ile Leu Cys 
        275                 280                 285             


Thr Lys Asp Glu Val Leu Ala Glu Gln Thr Ile Phe Lys Leu Asp Ala 
    290                 295                 300                 


Pro Asp Asp Lys Thr Val His Leu Leu Asp Arg Asp Asp Asp His Val 
305                 310                 315                 320 


Val Ala Arg Phe Thr Lys Val Phe Ile Glu Asp Val Ala Pro Gly His 
                325                 330                 335     


His Ala Ala Gln Arg Ser Gly Gln Arg Ser Val Leu Asp Asp Leu Tyr 
            340                 345                 350         


Ala Asn Thr Gln Val Ile Ser Ile Thr Ser Ala Ala Leu Lys Trp Val 
        355                 360                 365             


Val Lys His Gly Val Ser Asp Gly Ile Val Asn Arg Lys Asn Val Lys 
    370                 375                 380                 


Val Cys Val Gly Phe Asp Pro Leu Tyr Thr Leu Ser Thr His Asn Gly 
385                 390                 395                 400 


Ile Ser Leu Cys Ala Leu Leu Met Asp Glu Lys Leu Ser Val Leu Asn 
                405                 410                 415     


Ser Ala Cys Arg Met Thr Leu Arg Ser Leu Met Lys Thr Gly Arg Asp 
            420                 425                 430         


Ala Asp Ala His Arg Ala Phe Gln Arg Val Leu Ser Gln Gly Tyr Ala 
        435                 440                 445             


Ser Leu Met Cys Tyr Tyr His Pro Ser Arg Lys Leu Ala Tyr Gly Glu 
    450                 455                 460                 


Val Leu Leu Pro Glu Arg Ser Asn Asp Val Val Asp Gly Ile Lys Leu 
465                 470                 475                 480 


Gln Leu Asp Ala Ser Arg His Cys His Glu Cys Pro Val Leu Gln Gln 
                485                 490                 495     


Lys Val Val Glu Leu Glu Lys Gln Ile Val Met Gln Lys Ser Ile Gln 
            500                 505                 510         


Ser Asp Pro Thr Pro Met Ala Leu Gln Pro Leu Leu Ser Gln Leu Arg 
        515                 520                 525             


Glu Leu Ser Ser Glu Val Thr Arg Leu Gln Met Glu Leu Ser Arg Ala 
    530                 535                 540                 


Gln Ser Leu Asn Ala Gln Leu Glu Ala Asp Val Lys Ser Ala Gln Ser 
545                 550                 555                 560 


Cys Ser Leu Asp Met Tyr Leu Arg His His Thr Cys Ile Asn Gly His 
                565                 570                 575     


Ala Lys Glu Asp Glu Leu Leu Asp Ala Val Arg Val Ala Pro Asp Val 
            580                 585                 590         


Arg Arg Gln Ile Met Glu Arg Arg Ser Glu Val Arg Lys Gly Trp Cys 
        595                 600                 605             


Glu Arg Ile Ser Lys Glu Ala Ser Ala Glu Cys Gln Asn Val Ile Asp 
    610                 615                 620                 


Asp Leu Thr Leu Met Asn Gly Lys Gln Ala Gln Glu Ile Arg Glu Leu 
625                 630                 635                 640 


Arg Asp Ser Ala Glu Ser Tyr Glu Lys Gln Ile Ala Glu Leu Val Ser 
                645                 650                 655     


Thr Ile Thr Gln Asn Gln Met Thr Tyr Gln Gln Glu Leu Gln Ala Leu 
            660                 665                 670         


Val Ala Lys Asn Val Glu Leu Asp Thr Leu Asn Gln Arg Gln Ala Arg 
        675                 680                 685             


Ser Leu Arg Ile Thr Pro Ser Leu Leu Ser Val Thr Pro Thr Asp Ser 
    690                 695                 700                 


Val Asp Gly Ala Ala Asp Leu Ile Asp Phe Ser Val Pro Thr Asp Glu 
705                 710                 715                 720 


Leu 
    


<210>  19
<211>  1416
<212>  DNA
<213>  orthoreovirus

<400>  19
atgctattgg tcggatggat cctcaactgc gtgaggaagt ggtacgtcta ataattgcgt       60

tgacaagcga taatggagca gtgttgtcaa aagaactcgg gtcaagggtc acggcgcttg      120

agaaaacgtc ccagatacac tctgatacaa tccttaggat cactcaagga ctcgaggatg      180

caaataaacg aatcagcgct cttgagcaaa gtagggacgg tttggttgca tcagttagtg      240

atgcgcaact tgcaatctcc cgattggaag gcgctgtcgg agtcctccag acaactgtca      300

atggacttga ttcgagtgtt acccagttgg gtggtagagt gggacagctt gagacaggat      360

ttgcaggatt acgcaatgac tacagcagtc tctctacgcg aatgggtaat gtggaacgcg      420

acactggatc attaacgact gaattggcga cgctcacgtt acgtgttact tcgatccaat      480

cagacttcga gtctagagta tcgacattag agcgtaccgc agttaccagt gctgccgccc      540

ctttggcaat caataacaat cgtatgacga tggggctaaa cgacggattg acactatcag      600

ggaataatct tgccatccgg ttgcctggta acacgggatt aagtattcaa aatggtgggc      660

ttcaatttcg atttaacact aatcaatttc agattgtcaa taacagatta actcttaaaa      720

ccactgtttt tgatcccctc aattcgagag taagcacgat cgagcaaagc tatgttgcgt      780

ctgcagtggc gcctttaagg ttagatggca gcacgaaggt actggacatg ttgatagata      840

gctctacact cgagattaat gctaatgggc aactagctgt gaaatcaact tcgccgaact      900

taagatatcc gattgctgat atcagtggta gtattgggat gagccctaac tacagattta      960

ggcgaagtat gtggatagga cttatctcat actcgggtag tggactaagt tggaggatac     1020

aggtcaattc tgacgtcttt atcgttgatg actacataca catatgcctc ccggcgttta     1080

acggtttcac gatagctgac ggtggcgatc tgtcgttgaa ctttgttact ggattactgc     1140

cgccattact cactggcgat actgaacctg catttcataa cgacgtggtc acgtatggag     1200

cacggaccat ttctattgga ttatcagcag gcggcacacc tcaatacatc agcaagaatt     1260

tgtgggtgga gcaatggcaa gatggtgtcc tgagactgcg tgttgaaggg ggtgggatga     1320

tcacacattc gaatagtaaa tggcctgcca taacagtctc atatccacgt agcttcacgt     1380

gaggatcaga ccaccccacg gcactggggc acttaa                               1416


<210>  20
<211>  455
<212>  PRT
<213>  orthoreovirus

<400>  20

Met Asp Pro Gln Leu Arg Glu Glu Val Val Arg Leu Ile Ile Ala Leu 
1               5                   10                  15      


Thr Ser Asp Asn Gly Ala Val Leu Ser Lys Glu Leu Gly Ser Arg Val 
            20                  25                  30          


Thr Ala Leu Glu Lys Thr Ser Gln Ile His Ser Asp Thr Ile Leu Arg 
        35                  40                  45              


Ile Thr Gln Gly Leu Glu Asp Ala Asn Lys Arg Ile Ser Ala Leu Glu 
    50                  55                  60                  


Gln Ser Arg Asp Gly Leu Val Ala Ser Val Ser Asp Ala Gln Leu Ala 
65                  70                  75                  80  


Ile Ser Arg Leu Glu Gly Ala Val Gly Val Leu Gln Thr Thr Val Asn 
                85                  90                  95      


Gly Leu Asp Ser Ser Val Thr Gln Leu Gly Gly Arg Val Gly Gln Leu 
            100                 105                 110         


Glu Thr Gly Phe Ala Gly Leu Arg Asn Asp Tyr Ser Ser Leu Ser Thr 
        115                 120                 125             


Arg Met Gly Asn Val Glu Arg Asp Thr Gly Ser Leu Thr Thr Glu Leu 
    130                 135                 140                 


Ala Thr Leu Thr Leu Arg Val Thr Ser Ile Gln Ser Asp Phe Glu Ser 
145                 150                 155                 160 


Arg Val Ser Thr Leu Glu Arg Thr Ala Val Thr Ser Ala Ala Ala Pro 
                165                 170                 175     


Leu Ala Ile Asn Asn Asn Arg Met Thr Met Gly Leu Asn Asp Gly Leu 
            180                 185                 190         


Thr Leu Ser Gly Asn Asn Leu Ala Ile Arg Leu Pro Gly Asn Thr Gly 
        195                 200                 205             


Leu Ser Ile Gln Asn Gly Gly Leu Gln Phe Arg Phe Asn Thr Asn Gln 
    210                 215                 220                 


Phe Gln Ile Val Asn Asn Arg Leu Thr Leu Lys Thr Thr Val Phe Asp 
225                 230                 235                 240 


Pro Leu Asn Ser Arg Val Ser Thr Ile Glu Gln Ser Tyr Val Ala Ser 
                245                 250                 255     


Ala Val Ala Pro Leu Arg Leu Asp Gly Ser Thr Lys Val Leu Asp Met 
            260                 265                 270         


Leu Ile Asp Ser Ser Thr Leu Glu Ile Asn Ala Asn Gly Gln Leu Ala 
        275                 280                 285             


Val Lys Ser Thr Ser Pro Asn Leu Arg Tyr Pro Ile Ala Asp Ile Ser 
    290                 295                 300                 


Gly Ser Ile Gly Met Ser Pro Asn Tyr Arg Phe Arg Arg Ser Met Trp 
305                 310                 315                 320 


Ile Gly Leu Ile Ser Tyr Ser Gly Ser Gly Leu Ser Trp Arg Ile Gln 
                325                 330                 335     


Val Asn Ser Asp Val Phe Ile Val Asp Asp Tyr Ile His Ile Cys Leu 
            340                 345                 350         


Pro Ala Phe Asn Gly Phe Thr Ile Ala Asp Gly Gly Asp Leu Ser Leu 
        355                 360                 365             


Asn Phe Val Thr Gly Leu Leu Pro Pro Leu Leu Thr Gly Asp Thr Glu 
    370                 375                 380                 


Pro Ala Phe His Asn Asp Val Val Thr Tyr Gly Ala Arg Thr Ile Ser 
385                 390                 395                 400 


Ile Gly Leu Ser Ala Gly Gly Thr Pro Gln Tyr Ile Ser Lys Asn Leu 
                405                 410                 415     


Trp Val Glu Gln Trp Gln Asp Gly Val Leu Arg Leu Arg Val Glu Gly 
            420                 425                 430         


Gly Gly Met Ile Thr His Ser Asn Ser Lys Trp Pro Ala Ile Thr Val 
        435                 440                 445             


Ser Tyr Pro Arg Ser Phe Thr 
    450                 455 


<210>  21
<211>  1331
<212>  DNA
<213>  orthoreovirus

<400>  21
gctattcgct ggtcagttat ggctcgcgct gcgttcctat tcaagaccgt tggatttggt       60

ggcctgcaaa gtgtgccaat taatgatgag ttgtcgtcac atctacttcg agccggtaat      120

tcgccatggc agctgaccca gttcttagat tggataagtc ttggaagagg attagctaca      180

tcagctcttg ttccaaccgc tggttcaaga tattaccaga tgagttgttt actgagtggc      240

actctccaaa ttccatttcg tcctaatcat cgatgggggg atactaggtt tctgcgtcta      300

gtgtggtcag ctcctacgct tgacgggttg gttgttgccc caccgcaggt cttagctcag      360

ccggcgttac aggctcaggc agatcgagtg tatgattgtg atgactaccc attcttggct      420

cgtgacccga gatttaagca tcgagtgtat caacaattga gtgccgtgac tctgctcaat      480

ttgacgggat tcggtccaat ttcctatgtt cgagtagacg aagatatgtg gagtggagat      540

gtgaaccagc ttcttatgaa ttacttcggg catacgtttg cagaaattgc atacacatta      600

tgccaggctt cagccaatag accttgggag cacgatggta cgtacgcgag gatgactcaa      660

attatactgt ccttattctg gttatcgtat gttggtgtaa ttcatcaaca gaatacttac      720

cggacgttct atttccaatg caatcggcgt ggtgatgctg ctgaagtatg gattctttcc      780

tgttcattaa accactccgc ccagattaga ccgggtaatc gcagtctatt tgtcatgcca      840

acaagtccag actggaatat ggacgtcaat ctaatcttaa gttcaacgtt gacagggtgc      900

ttgtgttcga gctctcagtt accgctaatt gataataact cagtgcctgc ggtttcgcgg      960

aacattcacg gttggactgg tagagctggt aaccagctcc atggttttca agtgcgacga     1020

atggtgactg aattctgtga cagattgaga cgcgatgggg ttatgactca agctcagcaa     1080

aatcaagttg aagcgttggc aaatcaaact caacagttta agagggataa gcttgaggcc     1140

tgggctaggg aagatgatca gtataatcag gctcatccga attctccaat gttccgtacg     1200

aagccattta cgaatgcgca atggggacga ggaaataccg gagcgactag tgccgcaatt     1260

gcagccctta tctaatcgtc ttggagtgag ggggtccccc cacacccctc gcgactgacc     1320

acacattcat c                                                          1331


<210>  22
<211>  418
<212>  PRT
<213>  orthoreovirus

<400>  22

Met Ala Arg Ala Ala Phe Leu Phe Lys Thr Val Gly Phe Gly Gly Leu 
1               5                   10                  15      


Gln Ser Val Pro Ile Asn Asp Glu Leu Ser Ser His Leu Leu Arg Ala 
            20                  25                  30          


Gly Asn Ser Pro Trp Gln Leu Thr Gln Phe Leu Asp Trp Ile Ser Leu 
        35                  40                  45              


Gly Arg Gly Leu Ala Thr Ser Ala Leu Val Pro Thr Ala Gly Ser Arg 
    50                  55                  60                  


Tyr Tyr Gln Met Ser Cys Leu Leu Ser Gly Thr Leu Gln Ile Pro Phe 
65                  70                  75                  80  


Arg Pro Asn His Arg Trp Gly Asp Thr Arg Phe Leu Arg Leu Val Trp 
                85                  90                  95      


Ser Ala Pro Thr Leu Asp Gly Leu Val Val Ala Pro Pro Gln Val Leu 
            100                 105                 110         


Ala Gln Pro Ala Leu Gln Ala Gln Ala Asp Arg Val Tyr Asp Cys Asp 
        115                 120                 125             


Asp Tyr Pro Phe Leu Ala Arg Asp Pro Arg Phe Lys His Arg Val Tyr 
    130                 135                 140                 


Gln Gln Leu Ser Ala Val Thr Leu Leu Asn Leu Thr Gly Phe Gly Pro 
145                 150                 155                 160 


Ile Ser Tyr Val Arg Val Asp Glu Asp Met Trp Ser Gly Asp Val Asn 
                165                 170                 175     


Gln Leu Leu Met Asn Tyr Phe Gly His Thr Phe Ala Glu Ile Ala Tyr 
            180                 185                 190         


Thr Leu Cys Gln Ala Ser Ala Asn Arg Pro Trp Glu His Asp Gly Thr 
        195                 200                 205             


Tyr Ala Arg Met Thr Gln Ile Ile Leu Ser Leu Phe Trp Leu Ser Tyr 
    210                 215                 220                 


Val Gly Val Ile His Gln Gln Asn Thr Tyr Arg Thr Phe Tyr Phe Gln 
225                 230                 235                 240 


Cys Asn Arg Arg Gly Asp Ala Ala Glu Val Trp Ile Leu Ser Cys Ser 
                245                 250                 255     


Leu Asn His Ser Ala Gln Ile Arg Pro Gly Asn Arg Ser Leu Phe Val 
            260                 265                 270         


Met Pro Thr Ser Pro Asp Trp Asn Met Asp Val Asn Leu Ile Leu Ser 
        275                 280                 285             


Ser Thr Leu Thr Gly Cys Leu Cys Ser Ser Ser Gln Leu Pro Leu Ile 
    290                 295                 300                 


Asp Asn Asn Ser Val Pro Ala Val Ser Arg Asn Ile His Gly Trp Thr 
305                 310                 315                 320 


Gly Arg Ala Gly Asn Gln Leu His Gly Phe Gln Val Arg Arg Met Val 
                325                 330                 335     


Thr Glu Phe Cys Asp Arg Leu Arg Arg Asp Gly Val Met Thr Gln Ala 
            340                 345                 350         


Gln Gln Asn Gln Val Glu Ala Leu Ala Asn Gln Thr Gln Gln Phe Lys 
        355                 360                 365             


Arg Asp Lys Leu Glu Ala Trp Ala Arg Glu Asp Asp Gln Tyr Asn Gln 
    370                 375                 380                 


Ala His Pro Asn Ser Pro Met Phe Arg Thr Lys Pro Phe Thr Asn Ala 
385                 390                 395                 400 


Gln Trp Gly Arg Gly Asn Thr Gly Ala Thr Ser Ala Ala Ile Ala Ala 
                405                 410                 415     


Leu Ile 
        


<210>  23
<211>  1198
<212>  DNA
<213>  orthoreovirus

<400>  23
gctaaagtca cgcctgttgt cgtcactatg gcttcctcac tcagagctgc gatctctaag       60

attaagagag atgatgctgg tcagcaagtt tgtcccaatt atgtcatgct caggtcatcg      120

gtcacaacga aagtggtacg aaacgttgtt gagtatcaaa tccgtacagg tggattcttt      180

tcgtgcctag caatgttgag accgctccag tatgctaaac gtgaacgtct gcttggacaa      240

aggaatctgg aacgtatatc gactagggac attcttcaga cacgcgattt gcactcattg      300

tgcatgccaa ctcctgatgc gccaatgtcc aatcatcagg cagccaccat gagagagttg      360

atctgcagct atttcaaggt cgatcatgct gatgggttga aatatatacc catggatgag      420

agatattctc catcatcgct tgccagactg ttcactatgg gtatggctgg cctacacatt      480

accactgagc cttcctacaa acgtgtgccc atcatgcact tggcggcaga tttggactgc      540

atgacgttag ctttacccta catgattaca cttgatggtg acacggtggt acctgttgcc      600

ccaacgcttt ctgcagaaca gcttttggat gatggactta aggggttagc atgcatggat      660

atctcatacg gatgtgaggt ggacgctaac aaccgatcag ctggtgacca gagcatggat      720

tcttcacgat gcatcaatga gttatattgc gaggaaacgg cagaagctat ctgtgtactc      780

aaaacatgtc ttgtgctgaa ctgtatgcaa ttcaaacttg agatggatga tttagcacac      840

aacgctgctg agctggacaa gatacagatg atgatacctt ttagtgaacg cgttttcaga      900

atggcttctg catttgctac cattgatgcc cagtgtttca ggttttgtgt gatgatgaag      960

gataagaatt tgaagataga catgcgtgaa acgatgagac tttggactcg atcggcgctg     1020

gatgattcag tggctacgtc atctctgagt gtttcgctgg atcgaggtcg atgggtggca     1080

gctgatgcta atgatgctag attgctggtg tttccaattc gcgtgtaatg ggtgagtgag     1140

ccgatgtggt cgccaagaca tgtgccggtg tcttggtggt gggtggcgcc taatcatc       1198


<210>  24
<211>  366
<212>  PRT
<213>  orthoreovirus

<400>  24

Met Ala Ser Ser Leu Arg Ala Ala Ile Ser Lys Ile Lys Arg Asp Asp 
1               5                   10                  15      


Ala Gly Gln Gln Val Cys Pro Asn Tyr Val Met Leu Arg Ser Ser Val 
            20                  25                  30          


Thr Thr Lys Val Val Arg Asn Val Val Glu Tyr Gln Ile Arg Thr Gly 
        35                  40                  45              


Gly Phe Phe Ser Cys Leu Ala Met Leu Arg Pro Leu Gln Tyr Ala Lys 
    50                  55                  60                  


Arg Glu Arg Leu Leu Gly Gln Arg Asn Leu Glu Arg Ile Ser Thr Arg 
65                  70                  75                  80  


Asp Ile Leu Gln Thr Arg Asp Leu His Ser Leu Cys Met Pro Thr Pro 
                85                  90                  95      


Asp Ala Pro Met Ser Asn His Gln Ala Ala Thr Met Arg Glu Leu Ile 
            100                 105                 110         


Cys Ser Tyr Phe Lys Val Asp His Ala Asp Gly Leu Lys Tyr Ile Pro 
        115                 120                 125             


Met Asp Glu Arg Tyr Ser Pro Ser Ser Leu Ala Arg Leu Phe Thr Met 
    130                 135                 140                 


Gly Met Ala Gly Leu His Ile Thr Thr Glu Pro Ser Tyr Lys Arg Val 
145                 150                 155                 160 


Pro Ile Met His Leu Ala Ala Asp Leu Asp Cys Met Thr Leu Ala Leu 
                165                 170                 175     


Pro Tyr Met Ile Thr Leu Asp Gly Asp Thr Val Val Pro Val Ala Pro 
            180                 185                 190         


Thr Leu Ser Ala Glu Gln Leu Leu Asp Asp Gly Leu Lys Gly Leu Ala 
        195                 200                 205             


Cys Met Asp Ile Ser Tyr Gly Cys Glu Val Asp Ala Asn Asn Arg Ser 
    210                 215                 220                 


Ala Gly Asp Gln Ser Met Asp Ser Ser Arg Cys Ile Asn Glu Leu Tyr 
225                 230                 235                 240 


Cys Glu Glu Thr Ala Glu Ala Ile Cys Val Leu Lys Thr Cys Leu Val 
                245                 250                 255     


Leu Asn Cys Met Gln Phe Lys Leu Glu Met Asp Asp Leu Ala His Asn 
            260                 265                 270         


Ala Ala Glu Leu Asp Lys Ile Gln Met Met Ile Pro Phe Ser Glu Arg 
        275                 280                 285             


Val Phe Arg Met Ala Ser Ala Phe Ala Thr Ile Asp Ala Gln Cys Phe 
    290                 295                 300                 


Arg Phe Cys Val Met Met Lys Asp Lys Asn Leu Lys Ile Asp Met Arg 
305                 310                 315                 320 


Glu Thr Met Arg Leu Trp Thr Arg Ser Ala Leu Asp Asp Ser Val Ala 
                325                 330                 335     


Thr Ser Ser Leu Ser Val Ser Leu Asp Arg Gly Arg Trp Val Ala Ala 
            340                 345                 350         


Asp Ala Asn Asp Ala Arg Leu Leu Val Phe Pro Ile Arg Val 
        355                 360                 365     


<210>  25
<211>  1196
<212>  DNA
<213>  orthoreovirus

<400>  25
gctatttttg cctcttccta gacgttgtcg caatggaggt gtgtctacct aatggtcatc       60

agatcgtcga ctggattaac aatgcatttg aaggacgggt gtcgatttat agtgcacagc      120

aaggatggga taagacaatc tcagctcagc ctgatatgat ggtgtgtggt agcgctgttg      180

tttgcatgca ttgcttgggt gtggttggat cattacagcg aaagttgaac catctgcctc      240

atcataaatg taatcagcaa ttgcgtgagc aggattatgt tgacctacag tttgctgatc      300

gtgtaaccgc tcactggaaa cgtggcatgt tatcatttgt atctcagatg catgctatca      360

tgaacgatgt gacacctgag gagcttgaaa gagtgagaac tgatggtggc atcttggctg      420

agctcaactg gcttcaaata gagtctggat caatgtttcg ttcgattcac tcaaactgga      480

ctgaccccct tcaggtggtc gaagacctag atactcagct agatcgctat tggacagcat      540

tgaatttgat gattgattca tcggatctgg tgccaaactt catgatgcgt gacccatcgc      600

atgcctttaa tggagtgaag ctggagggtg aagcgcgaca gactcaattc ccgcgcacat      660

tcgattccgg gtcaaacttg aaatggggtg ttatggtata tgattattct gaacttgaag      720

gggattctca gaaaggacga tcttatagga gagagatcgt tactccagcg aaagactttg      780

gtcactttgg tttatcccat tattctcgcg caacgacgcc aatacttggc aagatgcctg      840

ctgtattttc tggtatgtta accgggaact gtaaaatgta tccgtttata aagggcactg      900

ctaagctgaa aacggttaag aagctagttg atgctgtgaa ctacacgtgg agttttgaga      960

agatcagata cgctttaggc cctggtggga tgacgggatg gtataataga actatgcagc     1020

aagcgccaat tgtgttgact cctgcggcac tgactatgtt tccggatatg accagatttg     1080

gtgatctaca gtatccaatc acgattggcg atccggctgt ccttgggtaa acgcctccat     1140

cttctcagcg ccgggcctga ccaacctggt gtgacgtggg acaggctcca ttcatc         1196


<210>  26
<211>  365
<212>  PRT
<213>  orthoreovirus

<400>  26

Met Glu Val Cys Leu Pro Asn Gly His Gln Ile Val Asp Trp Ile Asn 
1               5                   10                  15      


Asn Ala Phe Glu Gly Arg Val Ser Ile Tyr Ser Ala Gln Gln Gly Trp 
            20                  25                  30          


Asp Lys Thr Ile Ser Ala Gln Pro Asp Met Met Val Cys Gly Ser Ala 
        35                  40                  45              


Val Val Cys Met His Cys Leu Gly Val Val Gly Ser Leu Gln Arg Lys 
    50                  55                  60                  


Leu Asn His Leu Pro His His Lys Cys Asn Gln Gln Leu Arg Glu Gln 
65                  70                  75                  80  


Asp Tyr Val Asp Leu Gln Phe Ala Asp Arg Val Thr Ala His Trp Lys 
                85                  90                  95      


Arg Gly Met Leu Ser Phe Val Ser Gln Met His Ala Ile Met Asn Asp 
            100                 105                 110         


Val Thr Pro Glu Glu Leu Glu Arg Val Arg Thr Asp Gly Gly Ile Leu 
        115                 120                 125             


Ala Glu Leu Asn Trp Leu Gln Ile Glu Ser Gly Ser Met Phe Arg Ser 
    130                 135                 140                 


Ile His Ser Asn Trp Thr Asp Pro Leu Gln Val Val Glu Asp Leu Asp 
145                 150                 155                 160 


Thr Gln Leu Asp Arg Tyr Trp Thr Ala Leu Asn Leu Met Ile Asp Ser 
                165                 170                 175     


Ser Asp Leu Val Pro Asn Phe Met Met Arg Asp Pro Ser His Ala Phe 
            180                 185                 190         


Asn Gly Val Lys Leu Glu Gly Glu Ala Arg Gln Thr Gln Phe Pro Arg 
        195                 200                 205             


Thr Phe Asp Ser Gly Ser Asn Leu Lys Trp Gly Val Met Val Tyr Asp 
    210                 215                 220                 


Tyr Ser Glu Leu Glu Gly Asp Ser Gln Lys Gly Arg Ser Tyr Arg Arg 
225                 230                 235                 240 


Glu Ile Val Thr Pro Ala Lys Asp Phe Gly His Phe Gly Leu Ser His 
                245                 250                 255     


Tyr Ser Arg Ala Thr Thr Pro Ile Leu Gly Lys Met Pro Ala Val Phe 
            260                 265                 270         


Ser Gly Met Leu Thr Gly Asn Cys Lys Met Tyr Pro Phe Ile Lys Gly 
        275                 280                 285             


Thr Ala Lys Leu Lys Thr Val Lys Lys Leu Val Asp Ala Val Asn Tyr 
    290                 295                 300                 


Thr Trp Ser Phe Glu Lys Ile Arg Tyr Ala Leu Gly Pro Gly Gly Met 
305                 310                 315                 320 


Thr Gly Trp Tyr Asn Arg Thr Met Gln Gln Ala Pro Ile Val Leu Thr 
                325                 330                 335     


Pro Ala Ala Leu Thr Met Phe Pro Asp Met Thr Arg Phe Gly Asp Leu 
            340                 345                 350         


Gln Tyr Pro Ile Thr Ile Gly Asp Pro Ala Val Leu Gly 
        355                 360                 365 


<210>  27
<211>  3854
<212>  DNA
<213>  orthoreovirus

<400>  27
gctacacgtt ccacgacaat gtcatccatg atactgactc agtttggacc gttcattgaa       60

agcatctcag gaatcactga ccaatcgaac gacgtgtttg aagatgcggc aaaagcgttc      120

tctacgttta ctcgcagcga cgtctataag gcactggatg agataccttt ctctgatgat      180

gcaatgcttc ccatcccccc aactatatat accaaaccat ctcacgattc atattattac      240

atagatgctc taaaccgcgt acgtcgtaaa acatatcagg gccctgatga cgtgtacgta      300

cctaattgtt ccatcgttga attgctagag ccgcatgaga ctctgacatc ttatgggcgt      360

ttgtctgaag cgattgagaa tcgtgccaag gatggagaca gccaagccag aattgcgaca      420

acatacggta gaatcgctga gtctcaggct agacagatta aggctccatt ggagaagttt      480

gtgttggcac tattggtgtc cgaagcgggg ggttctctat atgacccagt tttgcagaag      540

tatgatgaga ttccagatct atcgcataat tgccctttat ggtgttttag agaaatctgt      600

cgtcacatat ctggtccatt accagatcga gcaccttatc tttacttatc ggcaggggtt      660

ttctggttaa tgtcaccacg gatgacgtct gcgatccctc cgttattatc tgatcttgtt      720

aatttagcta tcttacaaca gactgcgggt ttagatccat cattagtgaa actgggagtg      780

cagatatgcc ttcacgcggc agctagctca agttatgcat ggtttatcct aaagactaag      840

tctatttttc ctcaaaacac gttacatagt atgtatgagt ctctagaagg agggtactgt      900

cctaacctag aatggttaga gcctagatcg gactataaat ttatgtacat gggagtcatg      960

ccattgtcca ctaaatatgc taggtcggca ccatccaacg aaaagaaagc gcgggaactt     1020

ggtgagaaat atggattgag ttcagttgtc agtgagcttc gtaaacggac aatggcttat     1080

gttaaacatg actttgcttc ggtaaggtac attcgtgacg ccatggcatg tactagcggc     1140

atttttctgg taagaacacc caccgagacg gtattgcaag aatataccca aagtccggag     1200

attaaggttc ccatccccca caaagactgg acaggcccag taggtgaaat cagaattcta     1260

aaagatacaa ccagctccat cgcgcgctac ttgtatagaa catggtactt agcagcggca     1320

agaatggcgg ctcagccacg cacgtgggat ccattgttcc aggcgattat gagatctcaa     1380

tacgtgacag ctaggggtgg gtctggcgca gcactccgcg aatctctgta tgcaattaat     1440

gtgtcgttac ctgattttaa gggcttacca gtgaaggcag caactaagat atttcaggcg     1500

gcacaattag cgaacctgcc gttctcacac acatcagtgg ctatactagc tgacacttcg     1560

atgggattgc gaaaccaggt gcagaggcga ccacgatcca tcatgccctt aaatgtgccc     1620

caacagcagg tttcggcgcc acatacattg accgctgatt atatcaatta tcacatgaat     1680

ctatcgacta cgtctggtag cgcggtcatt gagaaagtga ttcctttagg tgtatacgct     1740

tcaagccctc ctaaccaatc gattaacatt gacatatctg cgtgcgacgc aagtattact     1800

tgggacttct ttctatccgt gattatggcg gctatacacg aaggtgtcgc tagtagctcc     1860

attggaaaac cgtttatggg ggttcctgca tccattgtaa atgatgagtc tgtcgttgga     1920

gtgagagctg ctaggccgat atcgggaatg cagaacatgg ttcagcatct atcaaaactg     1980

tacaaacgtg gattttcata tagagtgaac gactcttttt ctccaggcaa cgattttact     2040

catatgacta ccactttccc gtcaggttca acagccactt ctactgagca tactgccaat     2100

aatagtacga tgatggaaac tttcctgaca gtatggggac ccgaacatac tgacgacccc     2160

gacgtcttac gtctaatgaa gtctttgact attcaaagga attacgtgtg tcaaggtgat     2220

gatggattga tgattatcga tgggaatact gctggtaagg tgaaaagtga aactattcaa     2280

aagatgttag agttaatctc aaaatatggt gaggagtttg gatggaaata tgacatagcg     2340

tacgatggga ctgccgagta cctaaagctg tacttcatat ttggctgtcg aattccaaat     2400

cttagccgtc atccaattgt tggaaaagaa cgggcgaatt cttcagcaga ggagccatgg     2460

ccagcaattt tagatcagat tatgggtatc ttctttaatg gcgttcatga cgggttgcag     2520

tggcagcggt ggatacgtta ttcatgggct ctatgctgtg ctttctcacg ccaaaggaca     2580

atgattggcg agagcgtggg ttacattcaa tatcctatgt ggtcatttgt ctactgggga     2640

ttaccattgg taaaagtgtt cgggtcagac ccatggatat tctcttggta catgccgact     2700

ggggacttgg gaatgtatag ttggattagc ctaatacgcc ctctaatgac aagatggatg     2760

gtagctaatg gctatgtcac tgacaaatgc tcacccgtat tcgggaacgc agattatcgt     2820

aaatgtttca atgagattaa attatatcaa gggtattata tggcacaatt gcccaggaat     2880

cccacaaaat ctggacggac ggcccctcgg gaggtaagag agcagttcac tcaggcactc     2940

tctgattatc tgatgcagaa tccagaactg aagtcacgcg tgctgcgtgg tcgtagtgag     3000

tgggagaagt atggagcggg gataattcac aatcctccat cattattcga tgtcccccat     3060

aagtggtatc agggtgcgca agaggcggcg accgctacga gagaagagct ggcagaaatg     3120

gatgagacgt tgatacgcgc ccgaaggcac agttattcga gtttctcaaa attgttggag     3180

gcatacctgc ttgtgaaatg gcgaatgtgc gaggcccgcg aaccgtcggt tgatttgcga     3240

ttaccattgt gtgcgggtat tgacccacta aactcagatc cttttctcaa aatggtaagc     3300

gttggaccga tgcttcagag tacgcgaaag tactttgctc agacactatt catggcgaaa     3360

acggtgtcgg gtctcgacgt taacgcgatt gatagcgcgt tattacgact gcgaacattg     3420

ggcgctgata agaaagcatt aacagcgcag ttattaatgg tgggacttca ggagtcagag     3480

gcggatgcgt tggctgggaa gataatgttg caagatgtaa gtactgtgca attagctaga     3540

gtggtcaatt tagcggtgcc agatacttgg atgtcgttag attttgattc tatgttcaaa     3600

caccatgtca aactgcttcc caaagatgga cgccacctaa atactgatat tcctcctcgc     3660

atgggatggt tacgggccat tctacgattc ttaggtgctg gaatggtaat gactgcgact     3720

ggagttgctg tcgacatata tctggaggat atacacggtg gtggtcgatc acttggacag     3780

agattcatga cttggatgcg gcaggaagga cggtcagcgt gagtctacca tgggtcgtgg     3840

tgcgtcaact catc                                                       3854


<210>  28
<211>  1267
<212>  PRT
<213>  orthoreovirus

<400>  28

Met Ser Ser Met Ile Leu Thr Gln Phe Gly Pro Phe Ile Glu Ser Ile 
1               5                   10                  15      


Ser Gly Ile Thr Asp Gln Ser Asn Asp Val Phe Glu Asp Ala Ala Lys 
            20                  25                  30          


Ala Phe Ser Thr Phe Thr Arg Ser Asp Val Tyr Lys Ala Leu Asp Glu 
        35                  40                  45              


Ile Pro Phe Ser Asp Asp Ala Met Leu Pro Ile Pro Pro Thr Ile Tyr 
    50                  55                  60                  


Thr Lys Pro Ser His Asp Ser Tyr Tyr Tyr Ile Asp Ala Leu Asn Arg 
65                  70                  75                  80  


Val Arg Arg Lys Thr Tyr Gln Gly Pro Asp Asp Val Tyr Val Pro Asn 
                85                  90                  95      


Cys Ser Ile Val Glu Leu Leu Glu Pro His Glu Thr Leu Thr Ser Tyr 
            100                 105                 110         


Gly Arg Leu Ser Glu Ala Ile Glu Asn Arg Ala Lys Asp Gly Asp Ser 
        115                 120                 125             


Gln Ala Arg Ile Ala Thr Thr Tyr Gly Arg Ile Ala Glu Ser Gln Ala 
    130                 135                 140                 


Arg Gln Ile Lys Ala Pro Leu Glu Lys Phe Val Leu Ala Leu Leu Val 
145                 150                 155                 160 


Ser Glu Ala Gly Gly Ser Leu Tyr Asp Pro Val Leu Gln Lys Tyr Asp 
                165                 170                 175     


Glu Ile Pro Asp Leu Ser His Asn Cys Pro Leu Trp Cys Phe Arg Glu 
            180                 185                 190         


Ile Cys Arg His Ile Ser Gly Pro Leu Pro Asp Arg Ala Pro Tyr Leu 
        195                 200                 205             


Tyr Leu Ser Ala Gly Val Phe Trp Leu Met Ser Pro Arg Met Thr Ser 
    210                 215                 220                 


Ala Ile Pro Pro Leu Leu Ser Asp Leu Val Asn Leu Ala Ile Leu Gln 
225                 230                 235                 240 


Gln Thr Ala Gly Leu Asp Pro Ser Leu Val Lys Leu Gly Val Gln Ile 
                245                 250                 255     


Cys Leu His Ala Ala Ala Ser Ser Ser Tyr Ala Trp Phe Ile Leu Lys 
            260                 265                 270         


Thr Lys Ser Ile Phe Pro Gln Asn Thr Leu His Ser Met Tyr Glu Ser 
        275                 280                 285             


Leu Glu Gly Gly Tyr Cys Pro Asn Leu Glu Trp Leu Glu Pro Arg Ser 
    290                 295                 300                 


Asp Tyr Lys Phe Met Tyr Met Gly Val Met Pro Leu Ser Thr Lys Tyr 
305                 310                 315                 320 


Ala Arg Ser Ala Pro Ser Asn Glu Lys Lys Ala Arg Glu Leu Gly Glu 
                325                 330                 335     


Lys Tyr Gly Leu Ser Ser Val Val Ser Glu Leu Arg Lys Arg Thr Met 
            340                 345                 350         


Ala Tyr Val Lys His Asp Phe Ala Ser Val Arg Tyr Ile Arg Asp Ala 
        355                 360                 365             


Met Ala Cys Thr Ser Gly Ile Phe Leu Val Arg Thr Pro Thr Glu Thr 
    370                 375                 380                 


Val Leu Gln Glu Tyr Thr Gln Ser Pro Glu Ile Lys Val Pro Ile Pro 
385                 390                 395                 400 


His Lys Asp Trp Thr Gly Pro Val Gly Glu Ile Arg Ile Leu Lys Asp 
                405                 410                 415     


Thr Thr Ser Ser Ile Ala Arg Tyr Leu Tyr Arg Thr Trp Tyr Leu Ala 
            420                 425                 430         


Ala Ala Arg Met Ala Ala Gln Pro Arg Thr Trp Asp Pro Leu Phe Gln 
        435                 440                 445             


Ala Ile Met Arg Ser Gln Tyr Val Thr Ala Arg Gly Gly Ser Gly Ala 
    450                 455                 460                 


Ala Leu Arg Glu Ser Leu Tyr Ala Ile Asn Val Ser Leu Pro Asp Phe 
465                 470                 475                 480 


Lys Gly Leu Pro Val Lys Ala Ala Thr Lys Ile Phe Gln Ala Ala Gln 
                485                 490                 495     


Leu Ala Asn Leu Pro Phe Ser His Thr Ser Val Ala Ile Leu Ala Asp 
            500                 505                 510         


Thr Ser Met Gly Leu Arg Asn Gln Val Gln Arg Arg Pro Arg Ser Ile 
        515                 520                 525             


Met Pro Leu Asn Val Pro Gln Gln Gln Val Ser Ala Pro His Thr Leu 
    530                 535                 540                 


Thr Ala Asp Tyr Ile Asn Tyr His Met Asn Leu Ser Thr Thr Ser Gly 
545                 550                 555                 560 


Ser Ala Val Ile Glu Lys Val Ile Pro Leu Gly Val Tyr Ala Ser Ser 
                565                 570                 575     


Pro Pro Asn Gln Ser Ile Asn Ile Asp Ile Ser Ala Cys Asp Ala Ser 
            580                 585                 590         


Ile Thr Trp Asp Phe Phe Leu Ser Val Ile Met Ala Ala Ile His Glu 
        595                 600                 605             


Gly Val Ala Ser Ser Ser Ile Gly Lys Pro Phe Met Gly Val Pro Ala 
    610                 615                 620                 


Ser Ile Val Asn Asp Glu Ser Val Val Gly Val Arg Ala Ala Arg Pro 
625                 630                 635                 640 


Ile Ser Gly Met Gln Asn Met Val Gln His Leu Ser Lys Leu Tyr Lys 
                645                 650                 655     


Arg Gly Phe Ser Tyr Arg Val Asn Asp Ser Phe Ser Pro Gly Asn Asp 
            660                 665                 670         


Phe Thr His Met Thr Thr Thr Phe Pro Ser Gly Ser Thr Ala Thr Ser 
        675                 680                 685             


Thr Glu His Thr Ala Asn Asn Ser Thr Met Met Glu Thr Phe Leu Thr 
    690                 695                 700                 


Val Trp Gly Pro Glu His Thr Asp Asp Pro Asp Val Leu Arg Leu Met 
705                 710                 715                 720 


Lys Ser Leu Thr Ile Gln Arg Asn Tyr Val Cys Gln Gly Asp Asp Gly 
                725                 730                 735     


Leu Met Ile Ile Asp Gly Asn Thr Ala Gly Lys Val Lys Ser Glu Thr 
            740                 745                 750         


Ile Gln Lys Met Leu Glu Leu Ile Ser Lys Tyr Gly Glu Glu Phe Gly 
        755                 760                 765             


Trp Lys Tyr Asp Ile Ala Tyr Asp Gly Thr Ala Glu Tyr Leu Lys Leu 
    770                 775                 780                 


Tyr Phe Ile Phe Gly Cys Arg Ile Pro Asn Leu Ser Arg His Pro Ile 
785                 790                 795                 800 


Val Gly Lys Glu Arg Ala Asn Ser Ser Ala Glu Glu Pro Trp Pro Ala 
                805                 810                 815     


Ile Leu Asp Gln Ile Met Gly Ile Phe Phe Asn Gly Val His Asp Gly 
            820                 825                 830         


Leu Gln Trp Gln Arg Trp Ile Arg Tyr Ser Trp Ala Leu Cys Cys Ala 
        835                 840                 845             


Phe Ser Arg Gln Arg Thr Met Ile Gly Glu Ser Val Gly Tyr Ile Gln 
    850                 855                 860                 


Tyr Pro Met Trp Ser Phe Val Tyr Trp Gly Leu Pro Leu Val Lys Val 
865                 870                 875                 880 


Phe Gly Ser Asp Pro Trp Ile Phe Ser Trp Tyr Met Pro Thr Gly Asp 
                885                 890                 895     


Leu Gly Met Tyr Ser Trp Ile Ser Leu Ile Arg Pro Leu Met Thr Arg 
            900                 905                 910         


Trp Met Val Ala Asn Gly Tyr Val Thr Asp Lys Cys Ser Pro Val Phe 
        915                 920                 925             


Gly Asn Ala Asp Tyr Arg Lys Cys Phe Asn Glu Ile Lys Leu Tyr Gln 
    930                 935                 940                 


Gly Tyr Tyr Met Ala Gln Leu Pro Arg Asn Pro Thr Lys Ser Gly Arg 
945                 950                 955                 960 


Thr Ala Pro Arg Glu Val Arg Glu Gln Phe Thr Gln Ala Leu Ser Asp 
                965                 970                 975     


Tyr Leu Met Gln Asn Pro Glu Leu Lys Ser Arg Val Leu Arg Gly Arg 
            980                 985                 990         


Ser Glu Trp Glu Lys Tyr Gly Ala  Gly Ile Ile His Asn  Pro Pro Ser 
        995                 1000                 1005             


Leu Phe  Asp Val Pro His Lys  Trp Tyr Gln Gly Ala  Gln Glu Ala 
    1010                 1015                 1020             


Ala Thr  Ala Thr Arg Glu Glu  Leu Ala Glu Met Asp  Glu Thr Leu 
    1025                 1030                 1035             


Ile Arg  Ala Arg Arg His Ser  Tyr Ser Ser Phe Ser  Lys Leu Leu 
    1040                 1045                 1050             


Glu Ala  Tyr Leu Leu Val Lys  Trp Arg Met Cys Glu  Ala Arg Glu 
    1055                 1060                 1065             


Pro Ser  Val Asp Leu Arg Leu  Pro Leu Cys Ala Gly  Ile Asp Pro 
    1070                 1075                 1080             


Leu Asn  Ser Asp Pro Phe Leu  Lys Met Val Ser Val  Gly Pro Met 
    1085                 1090                 1095             


Leu Gln  Ser Thr Arg Lys Tyr  Phe Ala Gln Thr Leu  Phe Met Ala 
    1100                 1105                 1110             


Lys Thr  Val Ser Gly Leu Asp  Val Asn Ala Ile Asp  Ser Ala Leu 
    1115                 1120                 1125             


Leu Arg  Leu Arg Thr Leu Gly  Ala Asp Lys Lys Ala  Leu Thr Ala 
    1130                 1135                 1140             


Gln Leu  Leu Met Val Gly Leu  Gln Glu Ser Glu Ala  Asp Ala Leu 
    1145                 1150                 1155             


Ala Gly  Lys Ile Met Leu Gln  Asp Val Ser Thr Val  Gln Leu Ala 
    1160                 1165                 1170             


Arg Val  Val Asn Leu Ala Val  Pro Asp Thr Trp Met  Ser Leu Asp 
    1175                 1180                 1185             


Phe Asp  Ser Met Phe Lys His  His Val Lys Leu Leu  Pro Lys Asp 
    1190                 1195                 1200             


Gly Arg  His Leu Asn Thr Asp  Ile Pro Pro Arg Met  Gly Trp Leu 
    1205                 1210                 1215             


Arg Ala  Ile Leu Arg Phe Leu  Gly Ala Gly Met Val  Met Thr Ala 
    1220                 1225                 1230             


Thr Gly  Val Ala Val Asp Ile  Tyr Leu Glu Asp Ile  His Gly Gly 
    1235                 1240                 1245             


Gly Arg  Ser Leu Gly Gln Arg  Phe Met Thr Trp Met  Arg Gln Glu 
    1250                 1255                 1260             


Gly Arg  Ser Ala 
    1265         


<210>  29
<211>  3915
<212>  DNA
<213>  orthoreovirus

<400>  29
gctattggcg caatggcgaa cgtttgggga gtgagacttg cagactcttt atcgtcaccc       60

actattgaga caagaactcg tcattacaca ctccgcgatt tctgttccga cctggatgct      120

gtagttggca aggaaccctg gagaccctta cgcaatcaga gaacgaatga tattgtcgcc      180

gttcaattgt ttcggccact gcagggattg gtgcttgaca cgcagtttta tggattccct      240

ggcattttct cagaatggga acagtttata agagagaaac tacgcgtgtt gaaatatgaa      300

gttttgcgga tttacccgat cagtaattat aatcatgagc gtgtcaatgt cttcgtggca      360

aatgctcttg tcggtgcatt tctatccaac caagccttct atgacctgtt gcctctacta      420

ttaatacgtg ataccatgat aaatgactta cttgggacag gtgctgctct ttctcagttt      480

ttccaatctc atggtgaggt tttagaggtt gccgcaggaa ggaagtacct gcaaatgaag      540

aactactcga acgatgatga tgatccacct ttattcgcta aggatctgtc ggattatgcg      600

aaggcgtttt acagtgatac gtttgagact ttagaccgat tcttctggac acatgactca      660

tctgcgggcg tcctagtgca ttatgataag cctaccaatg ggaatcatta catcttgggt      720

actctgacgc agatggttag tgcgcctccg catatcatta acgctactga cgcattgttg      780

ctcgaatcgt gtttagaaca atttgcggag aatgtgagag ccaggccagc gcagcctgtt      840

ccaagattgg atcagtgtta ccatttacgg tggggtgctc aatatgttgg cgaggactca      900

ttgacgtacc gtttgggggt actttcacta ctggctacca acggatatca attagctaga      960

ccgatcccta agcagttaac gaatcgatgg ctttctagtt ttgtcagtca gataatgtcg     1020

gatggtgtga atgagacgcc attatggcct caagagagat atgtccaaat agcctacgat     1080

tcaccgtctg tagtcgacgg agctacgcac tatggttatg ttaggagaaa tcagttgcgg     1140

ttgggcatga gggtgtccgc tcttcagtca ttgagtgata ctccggctcc gatacagtgg     1200

ttaccgcagt atactattga tcaggcacct gttgatgagg gagatctaat ggtttcgcgg     1260

ttgactcaac taccgttacg ccctgattat ggtagcatat gggtcggtga cgctctatcg     1320

tattatgttg attacaaccg cagccataga gttgtactat catccgagct accacaacta     1380

ccagatacat actttgacgg agacgagcaa tacggtcgca gtctgttctc tttagcacga     1440

aaaatcggtg atcgatctct catcaaagat acagcagtgc tcaagcatgc gtaccaggcc     1500

atcgatccaa acactggaaa ggaatacctt cgcgcaggac agtctgttgc atatttcgga     1560

gcatcagctg gtcattcagg ggcggatcaa cctctagtaa ttgagccatg gacgcagggt     1620

aaaattagtg gtgtaccgca gccttcttca gtcagacagt ttgggtatga tgttgctaaa     1680

ggtgcgattg tggacttagc aagaccgttc ccgtcgggtg actaccaatt tgtatattct     1740

gacgtcgatc aggtcgttga cggccacgat gatctcagca tatcttcagg gctggtggag     1800

agtctattag attcctgcat gcatgccaca tccccaggtg ggtcgttcgt gatgaagata     1860

aatttcccga cacgtgatgt ctggcactat atagagcaaa agattctccc aaatattacc     1920

tcgtacatgt tgatcaaacc attcgtgact aacaatgtag agttattctt tgtggctttc     1980

ggtgtgcatc aacaatcagc attgacatgg acgtccgggg tgtatttctt cctggtcgat     2040

cacttctatc gatacgagac attgtctacg atttcacgtc agttgccatc gttcggatac     2100

gttgatgacg ggtcgtctgt gacaggtatt gagatgatca gtcttgaaaa tccaggcttt     2160

tcaaacatga cccaagctgc acgtgtcggg atatcagggc tgtgtgcgaa tgtcggtaat     2220

gcgcgcaaat taatatctat ccatgaatct cacggagcac gcgtgctcac catcatatcg     2280

agaagatctc cggcttcggc taggcggaaa gctcgcttac gctatttgcc actcatagac     2340

ccacgatctt tggaagtgca ggcacgtacg atattaccat ctaacccagt gctgtttgac     2400

aacgtaaaag gagcatcgcc tcacgtatgt ttgacgatga tgtataactt tgaagtatct     2460

agtgcggtgt atgatggtga tgtagtgctt gaccttggta ccggtcctga agcgaagatt     2520

ctggagctga ttcctccaac gtccccagta acatgcgtgg acattagacc gacggcacag     2580

cctagtggct gttggaacgt acgtacgaca tttctggagc ttgattacct aagtgatggc     2640

tggataacgg gtgtacgtgg cgacatcgtg acctgcatgc tgtccctggg tgctgctgct     2700

gctggaaaat ccatgacgtt cgacgcggca tttcaacagt tagtgaaagt gcttactaaa     2760

agtacagcta acgtactgct gatccaagtc aactgcccaa cggatgtaat ccgaacaatt     2820

aagggatatt tggagataga tcaaactaat aagcggtata gatttcccaa atttggccgt     2880

gatgaaccat actctgacat ggattcctta gagcgcatat gtcgtgctgc gtggccaaat     2940

tgttccatca cgtgggtgcc tttatcctat gatctacgtt ggactaaact tgctttgctt     3000

gaatcgacta cactgagcag tgcatcagtg agaattgctg agttgatgta caaatacatg     3060

ccagttatga ggatagatat tcatgggtta cccatggaaa agcaaggcaa tttcgtagtg     3120

ggtcagaact gttctctaac tataccgggc ttcaacgcac aggacgtgtt caactgctac     3180

ttcaattccg cgctcgcttt ctctactgag gatgttaatt cggcaatgat accacaagtg     3240

acggctcagt ttaacactag taaaggtgag tggtcattgg acatggtgtt ctcagacgct     3300

ggtatctaca caatgcaggc attagtaggt tccaacgcaa atcctgtgtc tttgggttcg     3360

tttgtagtgg attctccgga tgtcgacata acagatgcgt ggcctgctca gttagatttt     3420

accatagctg gcactgatgt caacatcaca gttaatcctt attaccgctt gatggccttt     3480

gtaaagattg atggacaatg gcagattgcg aaccctgata aattccaatt tttctcatca     3540

ggtacaggga cgttagtgat gaatgtaaag ttagatatag ctgataggta tttgctatat     3600

tacattcgcg acgttcaatc tagggatgtg ggattttaca tacagcaccc attacagtta     3660

ttaaatacaa ttacgttgcc tacaaacgag gatttattct tgagcgctcc tgacatgcgc     3720

gagtgggcgg taaaggaaag tggcaatacc atatgcatac ttaatagcca gggttttgtg     3780

ccacctcagg attgggatgt tcttaccgac actattagct ggtctccttc gctcccaact     3840

tatgtggtac ctccgggtga ttatactctg acacctctgt aactcattac ccctcgtaag     3900

cgtgcctaat tcatc                                                      3915


<210>  30
<211>  1289
<212>  PRT
<213>  orthoreovirus

<400>  30

Met Ala Asn Val Trp Gly Val Arg Leu Ala Asp Ser Leu Ser Ser Pro 
1               5                   10                  15      


Thr Ile Glu Thr Arg Thr Arg His Tyr Thr Leu Arg Asp Phe Cys Ser 
            20                  25                  30          


Asp Leu Asp Ala Val Val Gly Lys Glu Pro Trp Arg Pro Leu Arg Asn 
        35                  40                  45              


Gln Arg Thr Asn Asp Ile Val Ala Val Gln Leu Phe Arg Pro Leu Gln 
    50                  55                  60                  


Gly Leu Val Leu Asp Thr Gln Phe Tyr Gly Phe Pro Gly Ile Phe Ser 
65                  70                  75                  80  


Glu Trp Glu Gln Phe Ile Arg Glu Lys Leu Arg Val Leu Lys Tyr Glu 
                85                  90                  95      


Val Leu Arg Ile Tyr Pro Ile Ser Asn Tyr Asn His Glu Arg Val Asn 
            100                 105                 110         


Val Phe Val Ala Asn Ala Leu Val Gly Ala Phe Leu Ser Asn Gln Ala 
        115                 120                 125             


Phe Tyr Asp Leu Leu Pro Leu Leu Leu Ile Arg Asp Thr Met Ile Asn 
    130                 135                 140                 


Asp Leu Leu Gly Thr Gly Ala Ala Leu Ser Gln Phe Phe Gln Ser His 
145                 150                 155                 160 


Gly Glu Val Leu Glu Val Ala Ala Gly Arg Lys Tyr Leu Gln Met Lys 
                165                 170                 175     


Asn Tyr Ser Asn Asp Asp Asp Asp Pro Pro Leu Phe Ala Lys Asp Leu 
            180                 185                 190         


Ser Asp Tyr Ala Lys Ala Phe Tyr Ser Asp Thr Phe Glu Thr Leu Asp 
        195                 200                 205             


Arg Phe Phe Trp Thr His Asp Ser Ser Ala Gly Val Leu Val His Tyr 
    210                 215                 220                 


Asp Lys Pro Thr Asn Gly Asn His Tyr Ile Leu Gly Thr Leu Thr Gln 
225                 230                 235                 240 


Met Val Ser Ala Pro Pro His Ile Ile Asn Ala Thr Asp Ala Leu Leu 
                245                 250                 255     


Leu Glu Ser Cys Leu Glu Gln Phe Ala Glu Asn Val Arg Ala Arg Pro 
            260                 265                 270         


Ala Gln Pro Val Pro Arg Leu Asp Gln Cys Tyr His Leu Arg Trp Gly 
        275                 280                 285             


Ala Gln Tyr Val Gly Glu Asp Ser Leu Thr Tyr Arg Leu Gly Val Leu 
    290                 295                 300                 


Ser Leu Leu Ala Thr Asn Gly Tyr Gln Leu Ala Arg Pro Ile Pro Lys 
305                 310                 315                 320 


Gln Leu Thr Asn Arg Trp Leu Ser Ser Phe Val Ser Gln Ile Met Ser 
                325                 330                 335     


Asp Gly Val Asn Glu Thr Pro Leu Trp Pro Gln Glu Arg Tyr Val Gln 
            340                 345                 350         


Ile Ala Tyr Asp Ser Pro Ser Val Val Asp Gly Ala Thr His Tyr Gly 
        355                 360                 365             


Tyr Val Arg Arg Asn Gln Leu Arg Leu Gly Met Arg Val Ser Ala Leu 
    370                 375                 380                 


Gln Ser Leu Ser Asp Thr Pro Ala Pro Ile Gln Trp Leu Pro Gln Tyr 
385                 390                 395                 400 


Thr Ile Asp Gln Ala Pro Val Asp Glu Gly Asp Leu Met Val Ser Arg 
                405                 410                 415     


Leu Thr Gln Leu Pro Leu Arg Pro Asp Tyr Gly Ser Ile Trp Val Gly 
            420                 425                 430         


Asp Ala Leu Ser Tyr Tyr Val Asp Tyr Asn Arg Ser His Arg Val Val 
        435                 440                 445             


Leu Ser Ser Glu Leu Pro Gln Leu Pro Asp Thr Tyr Phe Asp Gly Asp 
    450                 455                 460                 


Glu Gln Tyr Gly Arg Ser Leu Phe Ser Leu Ala Arg Lys Ile Gly Asp 
465                 470                 475                 480 


Arg Ser Leu Ile Lys Asp Thr Ala Val Leu Lys His Ala Tyr Gln Ala 
                485                 490                 495     


Ile Asp Pro Asn Thr Gly Lys Glu Tyr Leu Arg Ala Gly Gln Ser Val 
            500                 505                 510         


Ala Tyr Phe Gly Ala Ser Ala Gly His Ser Gly Ala Asp Gln Pro Leu 
        515                 520                 525             


Val Ile Glu Pro Trp Thr Gln Gly Lys Ile Ser Gly Val Pro Gln Pro 
    530                 535                 540                 


Ser Ser Val Arg Gln Phe Gly Tyr Asp Val Ala Lys Gly Ala Ile Val 
545                 550                 555                 560 


Asp Leu Ala Arg Pro Phe Pro Ser Gly Asp Tyr Gln Phe Val Tyr Ser 
                565                 570                 575     


Asp Val Asp Gln Val Val Asp Gly His Asp Asp Leu Ser Ile Ser Ser 
            580                 585                 590         


Gly Leu Val Glu Ser Leu Leu Asp Ser Cys Met His Ala Thr Ser Pro 
        595                 600                 605             


Gly Gly Ser Phe Val Met Lys Ile Asn Phe Pro Thr Arg Asp Val Trp 
    610                 615                 620                 


His Tyr Ile Glu Gln Lys Ile Leu Pro Asn Ile Thr Ser Tyr Met Leu 
625                 630                 635                 640 


Ile Lys Pro Phe Val Thr Asn Asn Val Glu Leu Phe Phe Val Ala Phe 
                645                 650                 655     


Gly Val His Gln Gln Ser Ala Leu Thr Trp Thr Ser Gly Val Tyr Phe 
            660                 665                 670         


Phe Leu Val Asp His Phe Tyr Arg Tyr Glu Thr Leu Ser Thr Ile Ser 
        675                 680                 685             


Arg Gln Leu Pro Ser Phe Gly Tyr Val Asp Asp Gly Ser Ser Val Thr 
    690                 695                 700                 


Gly Ile Glu Met Ile Ser Leu Glu Asn Pro Gly Phe Ser Asn Met Thr 
705                 710                 715                 720 


Gln Ala Ala Arg Val Gly Ile Ser Gly Leu Cys Ala Asn Val Gly Asn 
                725                 730                 735     


Ala Arg Lys Leu Ile Ser Ile His Glu Ser His Gly Ala Arg Val Leu 
            740                 745                 750         


Thr Ile Ile Ser Arg Arg Ser Pro Ala Ser Ala Arg Arg Lys Ala Arg 
        755                 760                 765             


Leu Arg Tyr Leu Pro Leu Ile Asp Pro Arg Ser Leu Glu Val Gln Ala 
    770                 775                 780                 


Arg Thr Ile Leu Pro Ser Asn Pro Val Leu Phe Asp Asn Val Lys Gly 
785                 790                 795                 800 


Ala Ser Pro His Val Cys Leu Thr Met Met Tyr Asn Phe Glu Val Ser 
                805                 810                 815     


Ser Ala Val Tyr Asp Gly Asp Val Val Leu Asp Leu Gly Thr Gly Pro 
            820                 825                 830         


Glu Ala Lys Ile Leu Glu Leu Ile Pro Pro Thr Ser Pro Val Thr Cys 
        835                 840                 845             


Val Asp Ile Arg Pro Thr Ala Gln Pro Ser Gly Cys Trp Asn Val Arg 
    850                 855                 860                 


Thr Thr Phe Leu Glu Leu Asp Tyr Leu Ser Asp Gly Trp Ile Thr Gly 
865                 870                 875                 880 


Val Arg Gly Asp Ile Val Thr Cys Met Leu Ser Leu Gly Ala Ala Ala 
                885                 890                 895     


Ala Gly Lys Ser Met Thr Phe Asp Ala Ala Phe Gln Gln Leu Val Lys 
            900                 905                 910         


Val Leu Thr Lys Ser Thr Ala Asn Val Leu Leu Ile Gln Val Asn Cys 
        915                 920                 925             


Pro Thr Asp Val Ile Arg Thr Ile Lys Gly Tyr Leu Glu Ile Asp Gln 
    930                 935                 940                 


Thr Asn Lys Arg Tyr Arg Phe Pro Lys Phe Gly Arg Asp Glu Pro Tyr 
945                 950                 955                 960 


Ser Asp Met Asp Ser Leu Glu Arg Ile Cys Arg Ala Ala Trp Pro Asn 
                965                 970                 975     


Cys Ser Ile Thr Trp Val Pro Leu Ser Tyr Asp Leu Arg Trp Thr Lys 
            980                 985                 990         


Leu Ala Leu Leu Glu Ser Thr Thr  Leu Ser Ser Ala Ser  Val Arg Ile 
        995                 1000                 1005             


Ala Glu  Leu Met Tyr Lys Tyr  Met Pro Val Met Arg  Ile Asp Ile 
    1010                 1015                 1020             


His Gly  Leu Pro Met Glu Lys  Gln Gly Asn Phe Val  Val Gly Gln 
    1025                 1030                 1035             


Asn Cys  Ser Leu Thr Ile Pro  Gly Phe Asn Ala Gln  Asp Val Phe 
    1040                 1045                 1050             


Asn Cys  Tyr Phe Asn Ser Ala  Leu Ala Phe Ser Thr  Glu Asp Val 
    1055                 1060                 1065             


Asn Ser  Ala Met Ile Pro Gln  Val Thr Ala Gln Phe  Asn Thr Ser 
    1070                 1075                 1080             


Lys Gly  Glu Trp Ser Leu Asp  Met Val Phe Ser Asp  Ala Gly Ile 
    1085                 1090                 1095             


Tyr Thr  Met Gln Ala Leu Val  Gly Ser Asn Ala Asn  Pro Val Ser 
    1100                 1105                 1110             


Leu Gly  Ser Phe Val Val Asp  Ser Pro Asp Val Asp  Ile Thr Asp 
    1115                 1120                 1125             


Ala Trp  Pro Ala Gln Leu Asp  Phe Thr Ile Ala Gly  Thr Asp Val 
    1130                 1135                 1140             


Asn Ile  Thr Val Asn Pro Tyr  Tyr Arg Leu Met Ala  Phe Val Lys 
    1145                 1150                 1155             


Ile Asp  Gly Gln Trp Gln Ile  Ala Asn Pro Asp Lys  Phe Gln Phe 
    1160                 1165                 1170             


Phe Ser  Ser Gly Thr Gly Thr  Leu Val Met Asn Val  Lys Leu Asp 
    1175                 1180                 1185             


Ile Ala  Asp Arg Tyr Leu Leu  Tyr Tyr Ile Arg Asp  Val Gln Ser 
    1190                 1195                 1200             


Arg Asp  Val Gly Phe Tyr Ile  Gln His Pro Leu Gln  Leu Leu Asn 
    1205                 1210                 1215             


Thr Ile  Thr Leu Pro Thr Asn  Glu Asp Leu Phe Leu  Ser Ala Pro 
    1220                 1225                 1230             


Asp Met  Arg Glu Trp Ala Val  Lys Glu Ser Gly Asn  Thr Ile Cys 
    1235                 1240                 1245             


Ile Leu  Asn Ser Gln Gly Phe  Val Pro Pro Gln Asp  Trp Asp Val 
    1250                 1255                 1260             


Leu Thr  Asp Thr Ile Ser Trp  Ser Pro Ser Leu Pro  Thr Tyr Val 
    1265                 1270                 1275             


Val Pro  Pro Gly Asp Tyr Thr  Leu Thr Pro Leu 
    1280                 1285                 


<210>  31
<211>  3901
<212>  DNA
<213>  orthoreovirus

<400>  31
gctaatcgtc aggatgaagc ggattccaag gaagacaaag ggcaaatcca gcggaaaggg       60

caatgactca atagatagag cggacgatgg ctcaagccaa ttacgagaca agcaaaataa      120

taagaccggc cccgccacta cagagcctgg gacatccaac cgagagcagt acaaagctcg      180

accaagtatt gcatctgtgc agagggccac tgaaagtgca gaactaccta tgaagaacaa      240

tgacgaagga acgccagata agaagggaaa tactaagggc gacttagtca gtgaacatgg      300

tgaggctaaa gacgaggcgg atgaagcgac gaagaagcag gcaaaagata ctgatagaag      360

taaggcgcaa gttacatatt cagacactgg tatcaataat gctaatgaac tgtcaagatc      420

tgggaatgtg gataatgagg gtggaagtaa tcagaagccg atgtccacca gaatagctga      480

agcaacgtcg gctatagtgt cgaaacatcc tgcgcgtgtt gggttaccac ctaccgctag      540

cagtggtcat gggtatcagt gtcatgtctg ttctgcagtc ctgtttagtc ctttagacct      600

agacgcccac gtcgcctcac atggtttgca tggtaatatg acattgacat cgagtgagat      660

ccagcgacat atcactgagt ttatcagttc atggcaaaat catcctattg ttcaagtttc      720

ggctgacgtc gaaaataaga agactgctca attgctgcac gctgacactc ctcgacttgt      780

cacttgggat gctggtctgt gtacctcgtt taaaatcgtc ccgattgtgc cagctcaggt      840

accgcaggat gtattggcct atacgttctt tacctcttca tacgctattc aatcaccgtt      900

tccagaggcg gcagtgtcta ggattgtggt gcatacaaga tgggcatcta atgttgactt      960

cgaccgagat tcgtctgtca tcatggcacc acctacagaa aataatatcc atttgtttaa     1020

gcagttgcta aacactgata ccctgtctgt gagaggggcc aacccgctaa tgtttagagc     1080

gaatgtattg catatgttgc tggagttcgt attggataac ttgtatttga acagacatac     1140

gggattctct caagatcaca caccatttac tgagggcgct aatctgcgtt cacttcctgg     1200

ccccgatgct gagagatggt attcgattat gtatccaacg cgtatgggaa cgccgaacgt     1260

atcgaagata tgtaatttcg tcgcctcttg tgtgcgaaat cgagtcggaa ggtttgatcg     1320

agcacagatg atgaacggag ccatgtcaga gtgggtggat gtcttcgaga cttcagacgc     1380

gcttaccgtt tccattcgag gccgatggat ggctagatta gctcgcatga acataaatcc     1440

aacagagatc gagtgggcgt tgactgaatg tgcacaagga tatgtgactg ttacaagtcc     1500

ttacgctcct agcgtaaata gattgatgcc ctatcgtgtc tctaacgctg agcggcagat     1560

atcacagata atcaggatca tgaacatcgg caataacgcg acggtgatac agcctgttct     1620

gcaagatatt tcagtgctcc ttcaacgcat atcaccactc caaatagatc caaccattat     1680

ttccaacact atgtcaacag tttcggagtc tactactcag acactcagcc ccgcgtcctc     1740

aattttgggt aaattacgac cgagtaactc agatttctct agttttagag tcgcgttggc     1800

tggatggctt tataatggag ttgtgacgac ggtgattgat gatagttcat atccaaagga     1860

cgggggcagc gtgacctcac ttgaaaatct gtgggatttt ttcatccttg cgcttgcttt     1920

accactgaca actgacccat gtgcacctgt gaaagcgttt atgactttag ccaacatgat     1980

ggttggtttc gagacaatcc ccatggataa tcagatctat actcaatcga gacgtgcgag     2040

tgctttctca acgcctcata cgtggccacg atgcttcatg aacatccagt taatttctcc     2100

catcgacgct cccatcttac gacagtgggc tgaaattatt catagatact ggcctaatcc     2160

ttcacagatc cgttatggtg caccgaacgt ttttggttcg gcaaatctgt tcactccacc     2220

tgaggtgctg ttattgccaa tcgatcatca accagctaat gtgacaacgc cgacgctgga     2280

cttcaccaac gagttgacca attggcgcgc tcgtgtctgt gagcttatga agaatcttgt     2340

tgataatcaa agatatcaac ctggatggac acaaagtcta gtttcgtcaa tgcgcggaac     2400

gctggacaaa ttgaaattga tcaaatcgat gacaccaatg tatctgcaac agctggctcc     2460

ggtagagtta gcggtaatag ctcccatgtt gccttttcca cctttccagg tgccttacgt     2520

tcgacttgat cgtgacagag ttccaacaat ggtcggagta acacgacagt cacgagatac     2580

tattactcag ccagcgctgt cattgtcgac aaccaatacc actgttggtg tgcctttagc     2640

tctggacgca agggctatta ctgttgcgct gttgtcaggg aaatatccgc cggatctagt     2700

gacaaatgta tggtacgctg acgccattta tccaatgtat gcagatactg aggtgttctc     2760

taatcttcag agagacatga ttacttgcga agccgtgcag acgttagtga ctctggtggc     2820

gcagatatca gagacccagt atcctgtaga taggtatctt gattggatcc catcgctgag     2880

agcatcggca gcgacggcag caacgtttgc tgagtgggtt aatacttcaa tgaagacggc     2940

gtttgatttg tctgacatgc tgttagagcc tctactgagc ggggatccga ggatgactca     3000

actagcgatt cagtatcagc aatacaatgg cagaacgttt aatgtcatac ctgaaatgcc     3060

aggctcggtc atagctgact gtgttcaact aacagcagaa gtcttcaatc acgaatataa     3120

cctgtttgga attgcgaggg gtgatatcat cattggccgt gtccagtcga cacacttgtg     3180

gtcaccactg gctcctccac ctgatctggt gtttgatcgt gatactcctg gcgttcacat     3240

cttcggacga gattgccgta tatcgtttgg aatgaatggc gccgcgccaa tgattagaga     3300

tgagactgga atgatggtgc ctttcgaagg aaattggatt ttcccactgg cgctttggca     3360

aatgaatacg cgatatttta atcaacagtt cgatgcgtgg attaagacag gagagttgcg     3420

aatccgtatt gagatgggtg cgtacccata tatgttgcat tactatgatc cacgtcagta     3480

cgctaatgca tggaatttga catccgcctg gcttgaggaa attacaccga cgagcattcc     3540

atccgtgcct ttcatggtgc caatctcaag tgatcatgat atttcctctg ccccagctgt     3600

ccaatatatc atttcgactg aatataatga tcggtctcta ttctgcacta attcatcatc     3660

tccccaaacc atcgctggac cagacaaaca cattccagtt gaacgatata acattctgac     3720

caaccccgat gctccaccca cgcagataca actgcctgaa gttattgatt tgtataatgt     3780

cgtcacacgc tatgcgtatg agactccacc tattaccgct gttgttatgg gcgttccttg     3840

atcctcatcc tcccaacagg tgctagagca tcgcgctcga tgctagttgg gccgattcat     3900

c                                                                     3901


<210>  32
<211>  1275
<212>  PRT
<213>  orthoreovirus

<400>  32

Met Lys Arg Ile Pro Arg Lys Thr Lys Gly Lys Ser Ser Gly Lys Gly 
1               5                   10                  15      


Asn Asp Ser Ile Asp Arg Ala Asp Asp Gly Ser Ser Gln Leu Arg Asp 
            20                  25                  30          


Lys Gln Asn Asn Lys Thr Gly Pro Ala Thr Thr Glu Pro Gly Thr Ser 
        35                  40                  45              


Asn Arg Glu Gln Tyr Lys Ala Arg Pro Ser Ile Ala Ser Val Gln Arg 
    50                  55                  60                  


Ala Thr Glu Ser Ala Glu Leu Pro Met Lys Asn Asn Asp Glu Gly Thr 
65                  70                  75                  80  


Pro Asp Lys Lys Gly Asn Thr Lys Gly Asp Leu Val Ser Glu His Gly 
                85                  90                  95      


Glu Ala Lys Asp Glu Ala Asp Glu Ala Thr Lys Lys Gln Ala Lys Asp 
            100                 105                 110         


Thr Asp Arg Ser Lys Ala Gln Val Thr Tyr Ser Asp Thr Gly Ile Asn 
        115                 120                 125             


Asn Ala Asn Glu Leu Ser Arg Ser Gly Asn Val Asp Asn Glu Gly Gly 
    130                 135                 140                 


Ser Asn Gln Lys Pro Met Ser Thr Arg Ile Ala Glu Ala Thr Ser Ala 
145                 150                 155                 160 


Ile Val Ser Lys His Pro Ala Arg Val Gly Leu Pro Pro Thr Ala Ser 
                165                 170                 175     


Ser Gly His Gly Tyr Gln Cys His Val Cys Ser Ala Val Leu Phe Ser 
            180                 185                 190         


Pro Leu Asp Leu Asp Ala His Val Ala Ser His Gly Leu His Gly Asn 
        195                 200                 205             


Met Thr Leu Thr Ser Ser Glu Ile Gln Arg His Ile Thr Glu Phe Ile 
    210                 215                 220                 


Ser Ser Trp Gln Asn His Pro Ile Val Gln Val Ser Ala Asp Val Glu 
225                 230                 235                 240 


Asn Lys Lys Thr Ala Gln Leu Leu His Ala Asp Thr Pro Arg Leu Val 
                245                 250                 255     


Thr Trp Asp Ala Gly Leu Cys Thr Ser Phe Lys Ile Val Pro Ile Val 
            260                 265                 270         


Pro Ala Gln Val Pro Gln Asp Val Leu Ala Tyr Thr Phe Phe Thr Ser 
        275                 280                 285             


Ser Tyr Ala Ile Gln Ser Pro Phe Pro Glu Ala Ala Val Ser Arg Ile 
    290                 295                 300                 


Val Val His Thr Arg Trp Ala Ser Asn Val Asp Phe Asp Arg Asp Ser 
305                 310                 315                 320 


Ser Val Ile Met Ala Pro Pro Thr Glu Asn Asn Ile His Leu Phe Lys 
                325                 330                 335     


Gln Leu Leu Asn Thr Asp Thr Leu Ser Val Arg Gly Ala Asn Pro Leu 
            340                 345                 350         


Met Phe Arg Ala Asn Val Leu His Met Leu Leu Glu Phe Val Leu Asp 
        355                 360                 365             


Asn Leu Tyr Leu Asn Arg His Thr Gly Phe Ser Gln Asp His Thr Pro 
    370                 375                 380                 


Phe Thr Glu Gly Ala Asn Leu Arg Ser Leu Pro Gly Pro Asp Ala Glu 
385                 390                 395                 400 


Arg Trp Tyr Ser Ile Met Tyr Pro Thr Arg Met Gly Thr Pro Asn Val 
                405                 410                 415     


Ser Lys Ile Cys Asn Phe Val Ala Ser Cys Val Arg Asn Arg Val Gly 
            420                 425                 430         


Arg Phe Asp Arg Ala Gln Met Met Asn Gly Ala Met Ser Glu Trp Val 
        435                 440                 445             


Asp Val Phe Glu Thr Ser Asp Ala Leu Thr Val Ser Ile Arg Gly Arg 
    450                 455                 460                 


Trp Met Ala Arg Leu Ala Arg Met Asn Ile Asn Pro Thr Glu Ile Glu 
465                 470                 475                 480 


Trp Ala Leu Thr Glu Cys Ala Gln Gly Tyr Val Thr Val Thr Ser Pro 
                485                 490                 495     


Tyr Ala Pro Ser Val Asn Arg Leu Met Pro Tyr Arg Val Ser Asn Ala 
            500                 505                 510         


Glu Arg Gln Ile Ser Gln Ile Ile Arg Ile Met Asn Ile Gly Asn Asn 
        515                 520                 525             


Ala Thr Val Ile Gln Pro Val Leu Gln Asp Ile Ser Val Leu Leu Gln 
    530                 535                 540                 


Arg Ile Ser Pro Leu Gln Ile Asp Pro Thr Ile Ile Ser Asn Thr Met 
545                 550                 555                 560 


Ser Thr Val Ser Glu Ser Thr Thr Gln Thr Leu Ser Pro Ala Ser Ser 
                565                 570                 575     


Ile Leu Gly Lys Leu Arg Pro Ser Asn Ser Asp Phe Ser Ser Phe Arg 
            580                 585                 590         


Val Ala Leu Ala Gly Trp Leu Tyr Asn Gly Val Val Thr Thr Val Ile 
        595                 600                 605             


Asp Asp Ser Ser Tyr Pro Lys Asp Gly Gly Ser Val Thr Ser Leu Glu 
    610                 615                 620                 


Asn Leu Trp Asp Phe Phe Ile Leu Ala Leu Ala Leu Pro Leu Thr Thr 
625                 630                 635                 640 


Asp Pro Cys Ala Pro Val Lys Ala Phe Met Thr Leu Ala Asn Met Met 
                645                 650                 655     


Val Gly Phe Glu Thr Ile Pro Met Asp Asn Gln Ile Tyr Thr Gln Ser 
            660                 665                 670         


Arg Arg Ala Ser Ala Phe Ser Thr Pro His Thr Trp Pro Arg Cys Phe 
        675                 680                 685             


Met Asn Ile Gln Leu Ile Ser Pro Ile Asp Ala Pro Ile Leu Arg Gln 
    690                 695                 700                 


Trp Ala Glu Ile Ile His Arg Tyr Trp Pro Asn Pro Ser Gln Ile Arg 
705                 710                 715                 720 


Tyr Gly Ala Pro Asn Val Phe Gly Ser Ala Asn Leu Phe Thr Pro Pro 
                725                 730                 735     


Glu Val Leu Leu Leu Pro Ile Asp His Gln Pro Ala Asn Val Thr Thr 
            740                 745                 750         


Pro Thr Leu Asp Phe Thr Asn Glu Leu Thr Asn Trp Arg Ala Arg Val 
        755                 760                 765             


Cys Glu Leu Met Lys Asn Leu Val Asp Asn Gln Arg Tyr Gln Pro Gly 
    770                 775                 780                 


Trp Thr Gln Ser Leu Val Ser Ser Met Arg Gly Thr Leu Asp Lys Leu 
785                 790                 795                 800 


Lys Leu Ile Lys Ser Met Thr Pro Met Tyr Leu Gln Gln Leu Ala Pro 
                805                 810                 815     


Val Glu Leu Ala Val Ile Ala Pro Met Leu Pro Phe Pro Pro Phe Gln 
            820                 825                 830         


Val Pro Tyr Val Arg Leu Asp Arg Asp Arg Val Pro Thr Met Val Gly 
        835                 840                 845             


Val Thr Arg Gln Ser Arg Asp Thr Ile Thr Gln Pro Ala Leu Ser Leu 
    850                 855                 860                 


Ser Thr Thr Asn Thr Thr Val Gly Val Pro Leu Ala Leu Asp Ala Arg 
865                 870                 875                 880 


Ala Ile Thr Val Ala Leu Leu Ser Gly Lys Tyr Pro Pro Asp Leu Val 
                885                 890                 895     


Thr Asn Val Trp Tyr Ala Asp Ala Ile Tyr Pro Met Tyr Ala Asp Thr 
            900                 905                 910         


Glu Val Phe Ser Asn Leu Gln Arg Asp Met Ile Thr Cys Glu Ala Val 
        915                 920                 925             


Gln Thr Leu Val Thr Leu Val Ala Gln Ile Ser Glu Thr Gln Tyr Pro 
    930                 935                 940                 


Val Asp Arg Tyr Leu Asp Trp Ile Pro Ser Leu Arg Ala Ser Ala Ala 
945                 950                 955                 960 


Thr Ala Ala Thr Phe Ala Glu Trp Val Asn Thr Ser Met Lys Thr Ala 
                965                 970                 975     


Phe Asp Leu Ser Asp Met Leu Leu Glu Pro Leu Leu Ser Gly Asp Pro 
            980                 985                 990         


Arg Met Thr Gln Leu Ala Ile Gln  Tyr Gln Gln Tyr Asn  Gly Arg Thr 
        995                 1000                 1005             


Phe Asn  Val Ile Pro Glu Met  Pro Gly Ser Val Ile  Ala Asp Cys 
    1010                 1015                 1020             


Val Gln  Leu Thr Ala Glu Val  Phe Asn His Glu Tyr  Asn Leu Phe 
    1025                 1030                 1035             


Gly Ile  Ala Arg Gly Asp Ile  Ile Ile Gly Arg Val  Gln Ser Thr 
    1040                 1045                 1050             


His Leu  Trp Ser Pro Leu Ala  Pro Pro Pro Asp Leu  Val Phe Asp 
    1055                 1060                 1065             


Arg Asp  Thr Pro Gly Val His  Ile Phe Gly Arg Asp  Cys Arg Ile 
    1070                 1075                 1080             


Ser Phe  Gly Met Asn Gly Ala  Ala Pro Met Ile Arg  Asp Glu Thr 
    1085                 1090                 1095             


Gly Met  Met Val Pro Phe Glu  Gly Asn Trp Ile Phe  Pro Leu Ala 
    1100                 1105                 1110             


Leu Trp  Gln Met Asn Thr Arg  Tyr Phe Asn Gln Gln  Phe Asp Ala 
    1115                 1120                 1125             


Trp Ile  Lys Thr Gly Glu Leu  Arg Ile Arg Ile Glu  Met Gly Ala 
    1130                 1135                 1140             


Tyr Pro  Tyr Met Leu His Tyr  Tyr Asp Pro Arg Gln  Tyr Ala Asn 
    1145                 1150                 1155             


Ala Trp  Asn Leu Thr Ser Ala  Trp Leu Glu Glu Ile  Thr Pro Thr 
    1160                 1165                 1170             


Ser Ile  Pro Ser Val Pro Phe  Met Val Pro Ile Ser  Ser Asp His 
    1175                 1180                 1185             


Asp Ile  Ser Ser Ala Pro Ala  Val Gln Tyr Ile Ile  Ser Thr Glu 
    1190                 1195                 1200             


Tyr Asn  Asp Arg Ser Leu Phe  Cys Thr Asn Ser Ser  Ser Pro Gln 
    1205                 1210                 1215             


Thr Ile  Ala Gly Pro Asp Lys  His Ile Pro Val Glu  Arg Tyr Asn 
    1220                 1225                 1230             


Ile Leu  Thr Asn Pro Asp Ala  Pro Pro Thr Gln Ile  Gln Leu Pro 
    1235                 1240                 1245             


Glu Val  Ile Asp Leu Tyr Asn  Val Val Thr Arg Tyr  Ala Tyr Glu 
    1250                 1255                 1260             


Thr Pro  Pro Ile Thr Ala Val  Val Met Gly Val Pro  
    1265                 1270                 1275 


<210>  33
<211>  2304
<212>  DNA
<213>  orthoreovirus

<400>  33
gctcttcgcg gtcatggctt acatcgcagt tcctgcggtg gtggattcac gttcgagtga       60

ggctattgga ctactagaat cgtttggagt agacgctggg gctgatgtga atgatgtttc      120

atatcaagat catgactatg tgttggatca gttacagtat atgttagatg ggtatgaggc      180

tggtgacgtc atcgatgcac tcgtccacaa gaattggtta catcattctg tctattgctt      240

gttgccaccc aaaagtcaac tactagagta ttggaaaagt aacccttcag cgataccgga      300

caacgttgat cgtcggcttc gtaaacggct aatgctaaag aaagatctca gaaaagatga      360

tgagtacaat caattggcgc gtgctttcaa gatatcggat gtctacgcac cactcatctc      420

atctacgacg tcaccgatga caatgatcca gaacttgaat cagggcgaga tcgtgtacac      480

cacgacggac agagtaattg gggctagaat cttgttatat gctccaagaa agtactatgc      540

atcaactcta tcatttacta tgactaagtg catcattccg tttggcaaag aggtgggccg      600

tgctcctcac tctagattta atgttggcac attcccatca attgctactc cgaagtgttt      660

tgttatgagt ggggttgata ttgagtccat cccaaatgaa tttatcaaat tgttttacca      720

gcgcgtcaag agtgttcacg ctaatatact aaatgacata tcacctcaga tactctctga      780

catgataaac agaaagcgtt tgcgtgttca tactccatca gatcgtcgag ccgcgcaact      840

gatgcatttg ccctatcatg ttaagcgagg ggcgtctcac gtcgacgttt ataaggtaga      900

tgttgtggat gtattgtttg aggtagtaga tgtggccgat gggttgcgca atgtatctag      960

gaagctaact atgcacactg ttccggtctg tattcttgaa atgttgggta ttgagattgc     1020

ggactattgc gttcgtcgag aggatggaat gttcacagat tggttcttgc ttttaaccat     1080

gctatctgat ggcttaactg atagaaggac gcgttgtcaa tacctgatta atccgtcaag     1140

cgtgcctcct gatgtaatac ttaacatctc tattactgga tttataaaca ggcatacaat     1200

cgacgtcatg cctgacacat acgacttcat taaacccatt ggtgctgtgc tgcctaaggg     1260

atcattcaaa tcgacaatta tgagagttct tgactcaata tcaatattag gagttcagat     1320

catgccgcgc acgcatgtag tcgactcgga tgaggtgggc gagcaaatgg agcctacgtt     1380

tgagcatgcg gtcatggaga tatacagagg aattgctggc gttgactctc tggatgatct     1440

cattaggtgg gtgctgaact cggatctcat tccatatgat gacaggcttg gccaattatt     1500

tcaagcgttt ctgcctctcg caaaagattt gttagcgcca atggccagaa agttttatga     1560

taactcaatg agtgagggta gattgctgac attcgctcat gctgatagtg agttgctgaa     1620

cgcaaattac tttggtcatt tactgcgact aaaaatacca tatattacag aggttaattt     1680

gatgattcgc aagaatcgtg agggtgggga gctatttcag cttgtgttat cacatctata     1740

taaaatgtat gctactagcg cgcagcctaa atggtttgga tcattattgc gattgttaat     1800

atgtccctgg ttacatatgg agaaattgat aggagaagca gacccagcat ctacgtcggc     1860

tgaaattgga tggtatatct ctcgtgaaca gctgatgcaa gatggatggt gtggatgtga     1920

agatggattc attccctata ttagcatacg tgcgccaaag ctggttatag aggagttaat     1980

ggagaagaat tggggccaat atcatgcaca agttattatc actgatcggc ttgtcgtagg     2040

cgaaccgcgt agggtatctg ccaaggctgt ggtcaaaggt aaccacttac cagttaagtt     2100

agtctcacga tttgcatgtt tcacactgac gacgaagtat gagatgaggc tttcatgtgg     2160

ccatagcact ggacgggggg ctgcatacaa tgcgagacta gttttccgat ctgacttggc     2220

gtgatccgtg acatgcgtag tgtgacacct gcccctaggt caatgggggt agggggcggg     2280

ctaggactac gtacgcgctt catc                                            2304


<210>  34
<211>  736
<212>  PRT
<213>  orthoreovirus

<400>  34

Met Ala Tyr Ile Ala Val Pro Ala Val Val Asp Ser Arg Ser Ser Glu 
1               5                   10                  15      


Ala Ile Gly Leu Leu Glu Ser Phe Gly Val Asp Ala Gly Ala Asp Val 
            20                  25                  30          


Asn Asp Val Ser Tyr Gln Asp His Asp Tyr Val Leu Asp Gln Leu Gln 
        35                  40                  45              


Tyr Met Leu Asp Gly Tyr Glu Ala Gly Asp Val Ile Asp Ala Leu Val 
    50                  55                  60                  


His Lys Asn Trp Leu His His Ser Val Tyr Cys Leu Leu Pro Pro Lys 
65                  70                  75                  80  


Ser Gln Leu Leu Glu Tyr Trp Lys Ser Asn Pro Ser Ala Ile Pro Asp 
                85                  90                  95      


Asn Val Asp Arg Arg Leu Arg Lys Arg Leu Met Leu Lys Lys Asp Leu 
            100                 105                 110         


Arg Lys Asp Asp Glu Tyr Asn Gln Leu Ala Arg Ala Phe Lys Ile Ser 
        115                 120                 125             


Asp Val Tyr Ala Pro Leu Ile Ser Ser Thr Thr Ser Pro Met Thr Met 
    130                 135                 140                 


Ile Gln Asn Leu Asn Gln Gly Glu Ile Val Tyr Thr Thr Thr Asp Arg 
145                 150                 155                 160 


Val Ile Gly Ala Arg Ile Leu Leu Tyr Ala Pro Arg Lys Tyr Tyr Ala 
                165                 170                 175     


Ser Thr Leu Ser Phe Thr Met Thr Lys Cys Ile Ile Pro Phe Gly Lys 
            180                 185                 190         


Glu Val Gly Arg Ala Pro His Ser Arg Phe Asn Val Gly Thr Phe Pro 
        195                 200                 205             


Ser Ile Ala Thr Pro Lys Cys Phe Val Met Ser Gly Val Asp Ile Glu 
    210                 215                 220                 


Ser Ile Pro Asn Glu Phe Ile Lys Leu Phe Tyr Gln Arg Val Lys Ser 
225                 230                 235                 240 


Val His Ala Asn Ile Leu Asn Asp Ile Ser Pro Gln Ile Leu Ser Asp 
                245                 250                 255     


Met Ile Asn Arg Lys Arg Leu Arg Val His Thr Pro Ser Asp Arg Arg 
            260                 265                 270         


Ala Ala Gln Leu Met His Leu Pro Tyr His Val Lys Arg Gly Ala Ser 
        275                 280                 285             


His Val Asp Val Tyr Lys Val Asp Val Val Asp Val Leu Phe Glu Val 
    290                 295                 300                 


Val Asp Val Ala Asp Gly Leu Arg Asn Val Ser Arg Lys Leu Thr Met 
305                 310                 315                 320 


His Thr Val Pro Val Cys Ile Leu Glu Met Leu Gly Ile Glu Ile Ala 
                325                 330                 335     


Asp Tyr Cys Val Arg Arg Glu Asp Gly Met Phe Thr Asp Trp Phe Leu 
            340                 345                 350         


Leu Leu Thr Met Leu Ser Asp Gly Leu Thr Asp Arg Arg Thr Arg Cys 
        355                 360                 365             


Gln Tyr Leu Ile Asn Pro Ser Ser Val Pro Pro Asp Val Ile Leu Asn 
    370                 375                 380                 


Ile Ser Ile Thr Gly Phe Ile Asn Arg His Thr Ile Asp Val Met Pro 
385                 390                 395                 400 


Asp Thr Tyr Asp Phe Ile Lys Pro Ile Gly Ala Val Leu Pro Lys Gly 
                405                 410                 415     


Ser Phe Lys Ser Thr Ile Met Arg Val Leu Asp Ser Ile Ser Ile Leu 
            420                 425                 430         


Gly Val Gln Ile Met Pro Arg Thr His Val Val Asp Ser Asp Glu Val 
        435                 440                 445             


Gly Glu Gln Met Glu Pro Thr Phe Glu His Ala Val Met Glu Ile Tyr 
    450                 455                 460                 


Arg Gly Ile Ala Gly Val Asp Ser Leu Asp Asp Leu Ile Arg Trp Val 
465                 470                 475                 480 


Leu Asn Ser Asp Leu Ile Pro Tyr Asp Asp Arg Leu Gly Gln Leu Phe 
                485                 490                 495     


Gln Ala Phe Leu Pro Leu Ala Lys Asp Leu Leu Ala Pro Met Ala Arg 
            500                 505                 510         


Lys Phe Tyr Asp Asn Ser Met Ser Glu Gly Arg Leu Leu Thr Phe Ala 
        515                 520                 525             


His Ala Asp Ser Glu Leu Leu Asn Ala Asn Tyr Phe Gly His Leu Leu 
    530                 535                 540                 


Arg Leu Lys Ile Pro Tyr Ile Thr Glu Val Asn Leu Met Ile Arg Lys 
545                 550                 555                 560 


Asn Arg Glu Gly Gly Glu Leu Phe Gln Leu Val Leu Ser His Leu Tyr 
                565                 570                 575     


Lys Met Tyr Ala Thr Ser Ala Gln Pro Lys Trp Phe Gly Ser Leu Leu 
            580                 585                 590         


Arg Leu Leu Ile Cys Pro Trp Leu His Met Glu Lys Leu Ile Gly Glu 
        595                 600                 605             


Ala Asp Pro Ala Ser Thr Ser Ala Glu Ile Gly Trp Tyr Ile Ser Arg 
    610                 615                 620                 


Glu Gln Leu Met Gln Asp Gly Trp Cys Gly Cys Glu Asp Gly Phe Ile 
625                 630                 635                 640 


Pro Tyr Ile Ser Ile Arg Ala Pro Lys Leu Val Ile Glu Glu Leu Met 
                645                 650                 655     


Glu Lys Asn Trp Gly Gln Tyr His Ala Gln Val Ile Ile Thr Asp Arg 
            660                 665                 670         


Leu Val Val Gly Glu Pro Arg Arg Val Ser Ala Lys Ala Val Val Lys 
        675                 680                 685             


Gly Asn His Leu Pro Val Lys Leu Val Ser Arg Phe Ala Cys Phe Thr 
    690                 695                 700                 


Leu Thr Thr Lys Tyr Glu Met Arg Leu Ser Cys Gly His Ser Thr Gly 
705                 710                 715                 720 


Arg Gly Ala Ala Tyr Asn Ala Arg Leu Val Phe Arg Ser Asp Leu Ala 
                725                 730                 735     


<210>  35
<211>  2205
<212>  DNA
<213>  orthoreovirus

<400>  35
tgctaatctg ctgaccgtta ctctgcaaag atggggaacg cttcctctat tgttcagacg       60

atcaacgtca ctggagatgg caatgtgttc aaaccctcag ctgagacttc atccaccgct      120

gtaccgtcac taagtctatc acctggaatg ctaaatcctg gaggagtacc atggatcgcg      180

attggggatg agacatctgt tacttcaccg ggtgcgttgc ggcgaatgac ttcgaaggat      240

attccagaaa cagcgataat caacacagat aattcatcag gcgcggtgcc aagtgaatca      300

gcgttggtgc cttacaatga tgagccattg gtggtggtga cggagcatgc tatcgcaaac      360

tttactaaag ctgagatggc acttgaattc aatcgtgagt ttcttgataa attgcgcgta      420

ctgtcagtgt caccgaaata ttctgacctt ctaacgtatg ttgattgcta cgttggtgtg      480

tcggctcgtc aagccctaaa caatttccag aaacaggtac ctgtgattac acctactaga      540

caaacaatgt atgttgactc catacaggcg gccttgaaag cccttgagaa atgggaaatt      600

gatttgagag tggctcagac gctgttgcct acaaatgtcc caattgggga ggtttcttgt      660

ccaatgcagt cagtagtgaa actattagat gatcagctgc ccgacgatag ccttatacga      720

aggtatccta aggaggctgc tgttgctttg gccaaaagga acgggggaat acagtggatg      780

gatgtgtcag aaggtactgt gatgaacgag gccgtaaatg ctgttgcagc aagtgccctg      840

gcaccttccg cctcatcccc gcccctggaa gagaaatcaa aattgactga gcaagcgatg      900

gatcttgtaa ccgcagctga acctgagata gtcgcctctc tcgtgccagt tccagcgccc      960

gtgtttgcca ttccacctaa gccagccgat tataacgtgc gtaccctgaa gatcgatgag     1020

gccacatggt tgcgaatgat tccaaaaact atgagtacgc ctttccaaat tcaagtgact     1080

gataatacag gaactaaatg gcatcttaac ttgagaggag ggacacgcgt agtgaatctg     1140

gaccagattg ctccgatgag gttcgttctg gatctagggg gaaagagtta caaggagacg     1200

agttgggatc caaacggtaa gaaggttggg tttatcgtat tccagtctaa gattcctttt     1260

gagctttgga ccgctgcatc acagattggt caagccacag tggtcaacta tgttcagcta     1320

tatgctgaag acagctcatt taccgcccag tctattatcg ctactacatc gttggcttat     1380

aattatgaac cagagcaatt gaataagact gaccctgagg tgaactatta ccttctagcg     1440

acttttatag attcagctgc tataacaccg acgaacatga cacagcctga tgtttgggat     1500

gctatgttga cgatgtctcc attgtccgct ggggaggtga ctgtgaaggg tgcggtggta     1560

agcgaggtgg tgccagcgga attgatcggc agctatactc cagagtcatt aaatgcctca     1620

cttccgaatg acgctgctag atgtatgatt gatagagcct cgaaaatagc cgaagctata     1680

aagattgatg atgacgctgg gccagatgaa tactctccca actctgtacc aattcaaggt     1740

cagttggcta tttctcaact tgagactggg tatggtgtac ggatattcaa ttctaaggga     1800

attctttcga aaatcgcgtc cagagctatg caggctttta tcggtgatcc aagcacaatt     1860

atcacgcagg cggcaccagt gctgtcagat aagaacaatt ggattgcatt ggcacaagga     1920

gtcaagacta gtttgcgtac caaaagtcta tcagcggggg tgaagacggc ggtgagtaaa     1980

ctgagctcgt ccgagtctat tcagagttgg actcaaggat tcttggataa agtatcgatg     2040

cattttccag cgcctaagtc ggactgtccg accagcggag atagcagtga atcgtccgct     2100

cggcgagtga agcgcgactc atacgcagga gtggttaagc gtgggtatac acgttaagcc     2160

gctcgccctg gtgacgcggg gttaagggat gcaggcacat catca                     2205


<210>  36
<211>  708
<212>  PRT
<213>  orthoreovirus

<400>  36

Met Gly Asn Ala Ser Ser Ile Val Gln Thr Ile Asn Val Thr Gly Asp 
1               5                   10                  15      


Gly Asn Val Phe Lys Pro Ser Ala Glu Thr Ser Ser Thr Ala Val Pro 
            20                  25                  30          


Ser Leu Ser Leu Ser Pro Gly Met Leu Asn Pro Gly Gly Val Pro Trp 
        35                  40                  45              


Ile Ala Ile Gly Asp Glu Thr Ser Val Thr Ser Pro Gly Ala Leu Arg 
    50                  55                  60                  


Arg Met Thr Ser Lys Asp Ile Pro Glu Thr Ala Ile Ile Asn Thr Asp 
65                  70                  75                  80  


Asn Ser Ser Gly Ala Val Pro Ser Glu Ser Ala Leu Val Pro Tyr Asn 
                85                  90                  95      


Asp Glu Pro Leu Val Val Val Thr Glu His Ala Ile Ala Asn Phe Thr 
            100                 105                 110         


Lys Ala Glu Met Ala Leu Glu Phe Asn Arg Glu Phe Leu Asp Lys Leu 
        115                 120                 125             


Arg Val Leu Ser Val Ser Pro Lys Tyr Ser Asp Leu Leu Thr Tyr Val 
    130                 135                 140                 


Asp Cys Tyr Val Gly Val Ser Ala Arg Gln Ala Leu Asn Asn Phe Gln 
145                 150                 155                 160 


Lys Gln Val Pro Val Ile Thr Pro Thr Arg Gln Thr Met Tyr Val Asp 
                165                 170                 175     


Ser Ile Gln Ala Ala Leu Lys Ala Leu Glu Lys Trp Glu Ile Asp Leu 
            180                 185                 190         


Arg Val Ala Gln Thr Leu Leu Pro Thr Asn Val Pro Ile Gly Glu Val 
        195                 200                 205             


Ser Cys Pro Met Gln Ser Val Val Lys Leu Leu Asp Asp Gln Leu Pro 
    210                 215                 220                 


Asp Asp Ser Leu Ile Arg Arg Tyr Pro Lys Glu Ala Ala Val Ala Leu 
225                 230                 235                 240 


Ala Lys Arg Asn Gly Gly Ile Gln Trp Met Asp Val Ser Glu Gly Thr 
                245                 250                 255     


Val Met Asn Glu Ala Val Asn Ala Val Ala Ala Ser Ala Leu Ala Pro 
            260                 265                 270         


Ser Ala Ser Ser Pro Pro Leu Glu Glu Lys Ser Lys Leu Thr Glu Gln 
        275                 280                 285             


Ala Met Asp Leu Val Thr Ala Ala Glu Pro Glu Ile Val Ala Ser Leu 
    290                 295                 300                 


Val Pro Val Pro Ala Pro Val Phe Ala Ile Pro Pro Lys Pro Ala Asp 
305                 310                 315                 320 


Tyr Asn Val Arg Thr Leu Lys Ile Asp Glu Ala Thr Trp Leu Arg Met 
                325                 330                 335     


Ile Pro Lys Thr Met Ser Thr Pro Phe Gln Ile Gln Val Thr Asp Asn 
            340                 345                 350         


Thr Gly Thr Lys Trp His Leu Asn Leu Arg Gly Gly Thr Arg Val Val 
        355                 360                 365             


Asn Leu Asp Gln Ile Ala Pro Met Arg Phe Val Leu Asp Leu Gly Gly 
    370                 375                 380                 


Lys Ser Tyr Lys Glu Thr Ser Trp Asp Pro Asn Gly Lys Lys Val Gly 
385                 390                 395                 400 


Phe Ile Val Phe Gln Ser Lys Ile Pro Phe Glu Leu Trp Thr Ala Ala 
                405                 410                 415     


Ser Gln Ile Gly Gln Ala Thr Val Val Asn Tyr Val Gln Leu Tyr Ala 
            420                 425                 430         


Glu Asp Ser Ser Phe Thr Ala Gln Ser Ile Ile Ala Thr Thr Ser Leu 
        435                 440                 445             


Ala Tyr Asn Tyr Glu Pro Glu Gln Leu Asn Lys Thr Asp Pro Glu Val 
    450                 455                 460                 


Asn Tyr Tyr Leu Leu Ala Thr Phe Ile Asp Ser Ala Ala Ile Thr Pro 
465                 470                 475                 480 


Thr Asn Met Thr Gln Pro Asp Val Trp Asp Ala Met Leu Thr Met Ser 
                485                 490                 495     


Pro Leu Ser Ala Gly Glu Val Thr Val Lys Gly Ala Val Val Ser Glu 
            500                 505                 510         


Val Val Pro Ala Glu Leu Ile Gly Ser Tyr Thr Pro Glu Ser Leu Asn 
        515                 520                 525             


Ala Ser Leu Pro Asn Asp Ala Ala Arg Cys Met Ile Asp Arg Ala Ser 
    530                 535                 540                 


Lys Ile Ala Glu Ala Ile Lys Ile Asp Asp Asp Ala Gly Pro Asp Glu 
545                 550                 555                 560 


Tyr Ser Pro Asn Ser Val Pro Ile Gln Gly Gln Leu Ala Ile Ser Gln 
                565                 570                 575     


Leu Glu Thr Gly Tyr Gly Val Arg Ile Phe Asn Ser Lys Gly Ile Leu 
            580                 585                 590         


Ser Lys Ile Ala Ser Arg Ala Met Gln Ala Phe Ile Gly Asp Pro Ser 
        595                 600                 605             


Thr Ile Ile Thr Gln Ala Ala Pro Val Leu Ser Asp Lys Asn Asn Trp 
    610                 615                 620                 


Ile Ala Leu Ala Gln Gly Val Lys Thr Ser Leu Arg Thr Lys Ser Leu 
625                 630                 635                 640 


Ser Ala Gly Val Lys Thr Ala Val Ser Lys Leu Ser Ser Ser Glu Ser 
                645                 650                 655     


Ile Gln Ser Trp Thr Gln Gly Phe Leu Asp Lys Val Ser Met His Phe 
            660                 665                 670         


Pro Ala Pro Lys Ser Asp Cys Pro Thr Ser Gly Asp Ser Ser Glu Ser 
        675                 680                 685             


Ser Ala Arg Arg Val Lys Arg Asp Ser Tyr Ala Gly Val Val Lys Arg 
    690                 695                 700                 


Gly Tyr Thr Arg 
705             


<210>  37
<211>  2241
<212>  DNA
<213>  orthoreovirus

<400>  37
gctaaagtga ccgtggtcat ggcttcgttc aagggattct ccgccaacac tgttccagtt       60

tccaaggcca aacgtgacat atcatccctt gctgctactc ctggatttca ttcacaatcc      120

tttactccgt ctgtggatat gtctcaatcg cgtgaattcc tcacaaaagc aatcgagcag      180

gggtccatgt ctatacctta tcagcatgtg aatgtaccga aagttgatcg taaagttgtc      240

agcttggtag tgcggccttt ttcttcaggt gctttctcta tctctggagt gatttcgcca      300

gcccatgcct atctgctaga ttgtctacct cagcttgagc aggcaatggc ttttgttgct      360

tcacccgagt ctttccaggc ttcagatgtt gcaaagcgtt ttgctataaa gccaggtatg      420

agcctccagg acgctatcac tgcgtttatt aatttcgtgt ccgcgatgct gaaaatgacg      480

gtgactcgtc agaattttga tgttattgta gctgagatcg agaggcttgc ttcaaccagc      540

gtgtctgtca ggactgagga agcgaaggtt gctgatgagg agctgatgtt attcgggcta      600

gatcacagag ggccacagca gttggatatt tctgacgcta aagggataac gaaggctgct      660

gacattcaga caactcatga tgttcatctg gcacccggcg ttggtaatat tgaccctgaa      720

atctataacg aagggcggtt catgttcatg cagcacaaac cacttgcggc ggatcaatcg      780

tactttacct tagagactgc ggattatttc aagatttatc caacatatga cgaacatgat      840

ggtaggatgg ctgaccaaaa gcagtcggga ttgatactat gtactaaaga tgaagtgttg      900

gctgagcaaa ctatatttaa actggacgct cccgacgaca aaactgttca tctgttagat      960

cgtgacgacg accacgttgt tgccagattt accaaggtat ttatagaaga cgtagctccc     1020

gggcatcacg ctgctcagag atcgggacaa cgctctgtgc ttgatgacct atatgcgaat     1080

acgcaagtga tttccattac ctccgccgct ctgaagtggg tggttaaaca tggcgtgtct     1140

gatggaattg tgaataggaa gaatgtcaaa gtgtgtgttg gttttgaccc tttatacact     1200

ctgtccacgc ataacggaat atctctgtgt gccctgttga tggatgagaa gctttcggtg     1260

ctgaacagtg cgtgtcgtat gacgttgcgc tctctcatga agaccggacg tgatgctgat     1320

gcacacagag cttttcagcg agtcctttct caaggatacg catcgttaat gtgctattat     1380

cacccttcac ggaagctggc atatggcgag gtgcttcttc cagaacggtc caatgacgtg     1440

gtagatggga tcaagctaca gttggacgca tccagacatt gtcatgaatg tcctgtgttg     1500

cagcagaaag tggttgaatt ggaaaaacag atcgtcatgc aaaagtcgat tcagtcagac     1560

cctaccccaa tggcactgca accactgttg tctcagttgc gtgagctatc cagcgaagtt     1620

actaggctgc agatggagtt gagtagggct caatctttga atgcccagtt ggaggcggat     1680

gtcaaatcag ctcaatcatg cagcctggat atgtatctga gacaccacac ttgcattaat     1740

ggtcatgcta aagaggatga attgcttgat gctgtgcgtg tcgcaccgga tgtgaggagg     1800

caaatcatgg aaaggaggag tgaagtgaga aagggatggt gtgaacgtat ttctaaggaa     1860

gcgtctgccg aatgtcagaa tgttattgat gatctgactc tgatgaatgg aaagcaggcc     1920

caagagataa gagaattacg tgattcggct gagagttatg agaaacagat tgcggagctg     1980

gtgagtacca tcacccaaaa ccagatgact tatcagcaag agttacaagc cttagtagcg     2040

aaaaacgtgg aattggatac attgaatcaa cgtcaggcta ggtcgttgcg gattactccc     2100

tctcttctat cagtcactcc taccgattca gttgatggcg ctgctgacct aatcgatttc     2160

tctgttccga ctgatgagct gtaaatgatc cgtgatgcag tgttgtccta atcccttaag     2220

ccttcccgac ccccattcat c                                               2241


<210>  38
<211>  721
<212>  PRT
<213>  orthoreovirus

<400>  38

Met Ala Ser Phe Lys Gly Phe Ser Ala Asn Thr Val Pro Val Ser Lys 
1               5                   10                  15      


Ala Lys Arg Asp Ile Ser Ser Leu Ala Ala Thr Pro Gly Phe His Ser 
            20                  25                  30          


Gln Ser Phe Thr Pro Ser Val Asp Met Ser Gln Ser Arg Glu Phe Leu 
        35                  40                  45              


Thr Lys Ala Ile Glu Gln Gly Ser Met Ser Ile Pro Tyr Gln His Val 
    50                  55                  60                  


Asn Val Pro Lys Val Asp Arg Lys Val Val Ser Leu Val Val Arg Pro 
65                  70                  75                  80  


Phe Ser Ser Gly Ala Phe Ser Ile Ser Gly Val Ile Ser Pro Ala His 
                85                  90                  95      


Ala Tyr Leu Leu Asp Cys Leu Pro Gln Leu Glu Gln Ala Met Ala Phe 
            100                 105                 110         


Val Ala Ser Pro Glu Ser Phe Gln Ala Ser Asp Val Ala Lys Arg Phe 
        115                 120                 125             


Ala Ile Lys Pro Gly Met Ser Leu Gln Asp Ala Ile Thr Ala Phe Ile 
    130                 135                 140                 


Asn Phe Val Ser Ala Met Leu Lys Met Thr Val Thr Arg Gln Asn Phe 
145                 150                 155                 160 


Asp Val Ile Val Ala Glu Ile Glu Arg Leu Ala Ser Thr Ser Val Ser 
                165                 170                 175     


Val Arg Thr Glu Glu Ala Lys Val Ala Asp Glu Glu Leu Met Leu Phe 
            180                 185                 190         


Gly Leu Asp His Arg Gly Pro Gln Gln Leu Asp Ile Ser Asp Ala Lys 
        195                 200                 205             


Gly Ile Thr Lys Ala Ala Asp Ile Gln Thr Thr His Asp Val His Leu 
    210                 215                 220                 


Ala Pro Gly Val Gly Asn Ile Asp Pro Glu Ile Tyr Asn Glu Gly Arg 
225                 230                 235                 240 


Phe Met Phe Met Gln His Lys Pro Leu Ala Ala Asp Gln Ser Tyr Phe 
                245                 250                 255     


Thr Leu Glu Thr Ala Asp Tyr Phe Lys Ile Tyr Pro Thr Tyr Asp Glu 
            260                 265                 270         


His Asp Gly Arg Met Ala Asp Gln Lys Gln Ser Gly Leu Ile Leu Cys 
        275                 280                 285             


Thr Lys Asp Glu Val Leu Ala Glu Gln Thr Ile Phe Lys Leu Asp Ala 
    290                 295                 300                 


Pro Asp Asp Lys Thr Val His Leu Leu Asp Arg Asp Asp Asp His Val 
305                 310                 315                 320 


Val Ala Arg Phe Thr Lys Val Phe Ile Glu Asp Val Ala Pro Gly His 
                325                 330                 335     


His Ala Ala Gln Arg Ser Gly Gln Arg Ser Val Leu Asp Asp Leu Tyr 
            340                 345                 350         


Ala Asn Thr Gln Val Ile Ser Ile Thr Ser Ala Ala Leu Lys Trp Val 
        355                 360                 365             


Val Lys His Gly Val Ser Asp Gly Ile Val Asn Arg Lys Asn Val Lys 
    370                 375                 380                 


Val Cys Val Gly Phe Asp Pro Leu Tyr Thr Leu Ser Thr His Asn Gly 
385                 390                 395                 400 


Ile Ser Leu Cys Ala Leu Leu Met Asp Glu Lys Leu Ser Val Leu Asn 
                405                 410                 415     


Ser Ala Cys Arg Met Thr Leu Arg Ser Leu Met Lys Thr Gly Arg Asp 
            420                 425                 430         


Ala Asp Ala His Arg Ala Phe Gln Arg Val Leu Ser Gln Gly Tyr Ala 
        435                 440                 445             


Ser Leu Met Cys Tyr Tyr His Pro Ser Arg Lys Leu Ala Tyr Gly Glu 
    450                 455                 460                 


Val Leu Leu Pro Glu Arg Ser Asn Asp Val Val Asp Gly Ile Lys Leu 
465                 470                 475                 480 


Gln Leu Asp Ala Ser Arg His Cys His Glu Cys Pro Val Leu Gln Gln 
                485                 490                 495     


Lys Val Val Glu Leu Glu Lys Gln Ile Val Met Gln Lys Ser Ile Gln 
            500                 505                 510         


Ser Asp Pro Thr Pro Met Ala Leu Gln Pro Leu Leu Ser Gln Leu Arg 
        515                 520                 525             


Glu Leu Ser Ser Glu Val Thr Arg Leu Gln Met Glu Leu Ser Arg Ala 
    530                 535                 540                 


Gln Ser Leu Asn Ala Gln Leu Glu Ala Asp Val Lys Ser Ala Gln Ser 
545                 550                 555                 560 


Cys Ser Leu Asp Met Tyr Leu Arg His His Thr Cys Ile Asn Gly His 
                565                 570                 575     


Ala Lys Glu Asp Glu Leu Leu Asp Ala Val Arg Val Ala Pro Asp Val 
            580                 585                 590         


Arg Arg Gln Ile Met Glu Arg Arg Ser Glu Val Arg Lys Gly Trp Cys 
        595                 600                 605             


Glu Arg Ile Ser Lys Glu Ala Ser Ala Glu Cys Gln Asn Val Ile Asp 
    610                 615                 620                 


Asp Leu Thr Leu Met Asn Gly Lys Gln Ala Gln Glu Ile Arg Glu Leu 
625                 630                 635                 640 


Arg Asp Ser Ala Glu Ser Tyr Glu Lys Gln Ile Ala Glu Leu Val Ser 
                645                 650                 655     


Thr Ile Thr Gln Asn Gln Met Thr Tyr Gln Gln Glu Leu Gln Ala Leu 
            660                 665                 670         


Val Ala Lys Asn Val Glu Leu Asp Thr Leu Asn Gln Arg Gln Ala Arg 
        675                 680                 685             


Ser Leu Arg Ile Thr Pro Ser Leu Leu Ser Val Thr Pro Thr Asp Ser 
    690                 695                 700                 


Val Asp Gly Ala Ala Asp Leu Ile Asp Phe Ser Val Pro Thr Asp Glu 
705                 710                 715                 720 


Leu 
    


<210>  39
<211>  1416
<212>  DNA
<213>  orthoreovirus

<400>  39
atgctattgg tcggatggat cctcaactgc gtgaggaagt ggtacgtcta ataattgcgt       60

tgacaagcga taatggagca gtgttgtcaa aagaactcgg gtcaagggtc acggcgcttg      120

agaaaacgtc ccagatacac tctgatacaa tccttaggat cactcaagga ctcgaggatg      180

caaataaacg aatcagcgct cttgagcaaa gtagggacgg tttggttgca tcagttagtg      240

atgcgcaact tgcaatctcc cgattggaag gcgctgtcgg agtcctccag acaactgtca      300

atggacttga ttcgagtgtt acccagttgg gtggtagagt gggacagctt gagacaggat      360

ttgcaggatt acgcaatgac tacagcagtc tctctacgcg aatgggtaat gtggaacgcg      420

acactggatc attaacgact gaattggcga cgctcacgtt acgtgttact tcgatccaat      480

cagacttcga gtctagagta tcgacattag agcgtaccgc agttaccagt gctgccgccc      540

ctttggcaat caataacaat cgtatgacga tggggctaaa cgacggattg acactatcag      600

ggaataatct tgccatccgg ttgcctggta acacgggatt aagtattcaa aatggtgggc      660

ttcaatttcg atttaacact aatcaatttc agattgtcaa taacggatta actcttaaaa      720

ccactgtttt tgatcccctc aattcgagag taagcacgat cgagcaaagc tatgttgcgt      780

ctgcagtggc gcctttaagg ttagatggca gcacgaaggt actggacatg ttgatagata      840

gctctacact cgagattaat gctaatgggc aactagctgt gaaatcaact tcgccgaact      900

taagatatcc gattgctgat atcagtggta gtattgggat gagccctaac tacagattta      960

ggcgaagtat gtggatagga cttatctcat actcgggtag tggactaagt tggaggatac     1020

aggtcaattc tgacgtcttt atcgttgatg actacataca catatgcctc ccggcgttta     1080

acggtttcac gatagctgac ggtggcgatc tgtcgttgaa ctttgttact ggattactgc     1140

cgccattact cactggcgat actgaacctg catttcataa cgacgtggtc acgtatggag     1200

cacggaccat ttctattgga ttatcagcag gcggcacacc tcaatacatc agcaagaatt     1260

tgtgggtgga gcaatggcaa gatggtgtcc tgagactgcg tgttgaaggg ggtgggatga     1320

tcacacattc gaatagtaaa tggcctgcca taacagtctc atatccacgt agcttcacgt     1380

gaggatcaga ccaccccacg gcactggggc acttaa                               1416


<210>  40
<211>  455
<212>  PRT
<213>  orthoreovirus

<400>  40

Met Asp Pro Gln Leu Arg Glu Glu Val Val Arg Leu Ile Ile Ala Leu 
1               5                   10                  15      


Thr Ser Asp Asn Gly Ala Val Leu Ser Lys Glu Leu Gly Ser Arg Val 
            20                  25                  30          


Thr Ala Leu Glu Lys Thr Ser Gln Ile His Ser Asp Thr Ile Leu Arg 
        35                  40                  45              


Ile Thr Gln Gly Leu Glu Asp Ala Asn Lys Arg Ile Ser Ala Leu Glu 
    50                  55                  60                  


Gln Ser Arg Asp Gly Leu Val Ala Ser Val Ser Asp Ala Gln Leu Ala 
65                  70                  75                  80  


Ile Ser Arg Leu Glu Gly Ala Val Gly Val Leu Gln Thr Thr Val Asn 
                85                  90                  95      


Gly Leu Asp Ser Ser Val Thr Gln Leu Gly Gly Arg Val Gly Gln Leu 
            100                 105                 110         


Glu Thr Gly Phe Ala Gly Leu Arg Asn Asp Tyr Ser Ser Leu Ser Thr 
        115                 120                 125             


Arg Met Gly Asn Val Glu Arg Asp Thr Gly Ser Leu Thr Thr Glu Leu 
    130                 135                 140                 


Ala Thr Leu Thr Leu Arg Val Thr Ser Ile Gln Ser Asp Phe Glu Ser 
145                 150                 155                 160 


Arg Val Ser Thr Leu Glu Arg Thr Ala Val Thr Ser Ala Ala Ala Pro 
                165                 170                 175     


Leu Ala Ile Asn Asn Asn Arg Met Thr Met Gly Leu Asn Asp Gly Leu 
            180                 185                 190         


Thr Leu Ser Gly Asn Asn Leu Ala Ile Arg Leu Pro Gly Asn Thr Gly 
        195                 200                 205             


Leu Ser Ile Gln Asn Gly Gly Leu Gln Phe Arg Phe Asn Thr Asn Gln 
    210                 215                 220                 


Phe Gln Ile Val Asn Asn Gly Leu Thr Leu Lys Thr Thr Val Phe Asp 
225                 230                 235                 240 


Pro Leu Asn Ser Arg Val Ser Thr Ile Glu Gln Ser Tyr Val Ala Ser 
                245                 250                 255     


Ala Val Ala Pro Leu Arg Leu Asp Gly Ser Thr Lys Val Leu Asp Met 
            260                 265                 270         


Leu Ile Asp Ser Ser Thr Leu Glu Ile Asn Ala Asn Gly Gln Leu Ala 
        275                 280                 285             


Val Lys Ser Thr Ser Pro Asn Leu Arg Tyr Pro Ile Ala Asp Ile Ser 
    290                 295                 300                 


Gly Ser Ile Gly Met Ser Pro Asn Tyr Arg Phe Arg Arg Ser Met Trp 
305                 310                 315                 320 


Ile Gly Leu Ile Ser Tyr Ser Gly Ser Gly Leu Ser Trp Arg Ile Gln 
                325                 330                 335     


Val Asn Ser Asp Val Phe Ile Val Asp Asp Tyr Ile His Ile Cys Leu 
            340                 345                 350         


Pro Ala Phe Asn Gly Phe Thr Ile Ala Asp Gly Gly Asp Leu Ser Leu 
        355                 360                 365             


Asn Phe Val Thr Gly Leu Leu Pro Pro Leu Leu Thr Gly Asp Thr Glu 
    370                 375                 380                 


Pro Ala Phe His Asn Asp Val Val Thr Tyr Gly Ala Arg Thr Ile Ser 
385                 390                 395                 400 


Ile Gly Leu Ser Ala Gly Gly Thr Pro Gln Tyr Ile Ser Lys Asn Leu 
                405                 410                 415     


Trp Val Glu Gln Trp Gln Asp Gly Val Leu Arg Leu Arg Val Glu Gly 
            420                 425                 430         


Gly Gly Met Ile Thr His Ser Asn Ser Lys Trp Pro Ala Ile Thr Val 
        435                 440                 445             


Ser Tyr Pro Arg Ser Phe Thr 
    450                 455 


<210>  41
<211>  1331
<212>  DNA
<213>  orthoreovirus

<400>  41
gctattcgct ggtcagttat ggctcgcgct gcgttcctat tcaagaccgt tggatttggt       60

ggcctgcaaa gtgtgccaat taatgatgag ttgtcgtcac atctacttcg agccggtaat      120

tcgccatggc agctgaccca gttcttagat tggataagtc ttggaagagg attagctaca      180

tcagctcttg ttccaaccgc tggttcaaga tattaccaga tgagttgttt actgagtggc      240

actctccaaa ttccatttcg tcctaatcat cgatgggggg atactaggtt tctgcgtcta      300

gtgtggtcag ctcctacgct tgacgggttg gttgttgccc caccgcaggt cttagctcag      360

ccggcgttac aggctcaggc agatcgagtg tatgattgtg atgactaccc attcttggct      420

cgtgacccga gatttaagca tcgagtgtat caacaattga gtgccgtgac tctgctcaat      480

ttgacgggat tcggtccaat ttcctatgtt cgagtagacg aagatatgtg gagtggagat      540

gtgaaccagc ttcttatgaa ttacttcggg catacgtttg cagaaattgc atacacatta      600

tgccaggctt cagccaatag accttgggag cacgatggta cgtacgcgag gatgactcaa      660

attatactgt ccttattctg gttatcgtat gttggtgtaa ttcatcaaca gaatacttac      720

cggacgttct atttccaatg caatcggcgt ggtgatgctg ctgaagtatg gattctttcc      780

tgttcattaa accactccgc ccagattaga ccgggtaatc gcagtctatt tgtcatgcca      840

acaagtccag actggaatat ggacgtcaat ctaatcttaa gttcaacgtt gacagggtgc      900

ttgtgttcga gctctcagtt accgctaatt gataataact cagtgcctgc ggtttcgcgg      960

aacattcacg gttggactgg tagagctggt aaccagctcc atggttttca agtgcgacga     1020

atggtgactg aattctgtga cagattgaga cgcgatgggg ttatgactca agctcagcaa     1080

aatcaagttg aagcgttggc agatcaaact caacagttta agagggataa gcttgaggcc     1140

tgggctaggg aagatgatca gtataatcag gctcatccga attctccaat gttccgtacg     1200

aagccattta cgaatgcgca atggggacga ggaaataccg gagcgactag tgccgcaatt     1260

gcagccctta tctaatcgtc ttggagtgag ggggtccccc cacacccctc gcgactgacc     1320

acacattcat c                                                          1331


<210>  42
<211>  418
<212>  PRT
<213>  orthoreovirus

<400>  42

Met Ala Arg Ala Ala Phe Leu Phe Lys Thr Val Gly Phe Gly Gly Leu 
1               5                   10                  15      


Gln Ser Val Pro Ile Asn Asp Glu Leu Ser Ser His Leu Leu Arg Ala 
            20                  25                  30          


Gly Asn Ser Pro Trp Gln Leu Thr Gln Phe Leu Asp Trp Ile Ser Leu 
        35                  40                  45              


Gly Arg Gly Leu Ala Thr Ser Ala Leu Val Pro Thr Ala Gly Ser Arg 
    50                  55                  60                  


Tyr Tyr Gln Met Ser Cys Leu Leu Ser Gly Thr Leu Gln Ile Pro Phe 
65                  70                  75                  80  


Arg Pro Asn His Arg Trp Gly Asp Thr Arg Phe Leu Arg Leu Val Trp 
                85                  90                  95      


Ser Ala Pro Thr Leu Asp Gly Leu Val Val Ala Pro Pro Gln Val Leu 
            100                 105                 110         


Ala Gln Pro Ala Leu Gln Ala Gln Ala Asp Arg Val Tyr Asp Cys Asp 
        115                 120                 125             


Asp Tyr Pro Phe Leu Ala Arg Asp Pro Arg Phe Lys His Arg Val Tyr 
    130                 135                 140                 


Gln Gln Leu Ser Ala Val Thr Leu Leu Asn Leu Thr Gly Phe Gly Pro 
145                 150                 155                 160 


Ile Ser Tyr Val Arg Val Asp Glu Asp Met Trp Ser Gly Asp Val Asn 
                165                 170                 175     


Gln Leu Leu Met Asn Tyr Phe Gly His Thr Phe Ala Glu Ile Ala Tyr 
            180                 185                 190         


Thr Leu Cys Gln Ala Ser Ala Asn Arg Pro Trp Glu His Asp Gly Thr 
        195                 200                 205             


Tyr Ala Arg Met Thr Gln Ile Ile Leu Ser Leu Phe Trp Leu Ser Tyr 
    210                 215                 220                 


Val Gly Val Ile His Gln Gln Asn Thr Tyr Arg Thr Phe Tyr Phe Gln 
225                 230                 235                 240 


Cys Asn Arg Arg Gly Asp Ala Ala Glu Val Trp Ile Leu Ser Cys Ser 
                245                 250                 255     


Leu Asn His Ser Ala Gln Ile Arg Pro Gly Asn Arg Ser Leu Phe Val 
            260                 265                 270         


Met Pro Thr Ser Pro Asp Trp Asn Met Asp Val Asn Leu Ile Leu Ser 
        275                 280                 285             


Ser Thr Leu Thr Gly Cys Leu Cys Ser Ser Ser Gln Leu Pro Leu Ile 
    290                 295                 300                 


Asp Asn Asn Ser Val Pro Ala Val Ser Arg Asn Ile His Gly Trp Thr 
305                 310                 315                 320 


Gly Arg Ala Gly Asn Gln Leu His Gly Phe Gln Val Arg Arg Met Val 
                325                 330                 335     


Thr Glu Phe Cys Asp Arg Leu Arg Arg Asp Gly Val Met Thr Gln Ala 
            340                 345                 350         


Gln Gln Asn Gln Val Glu Ala Leu Ala Asp Gln Thr Gln Gln Phe Lys 
        355                 360                 365             


Arg Asp Lys Leu Glu Ala Trp Ala Arg Glu Asp Asp Gln Tyr Asn Gln 
    370                 375                 380                 


Ala His Pro Asn Ser Pro Met Phe Arg Thr Lys Pro Phe Thr Asn Ala 
385                 390                 395                 400 


Gln Trp Gly Arg Gly Asn Thr Gly Ala Thr Ser Ala Ala Ile Ala Ala 
                405                 410                 415     


Leu Ile 
        


<210>  43
<211>  1198
<212>  DNA
<213>  orthoreovirus

<400>  43
gctaaagtca cgcctgttgt cgtcactatg gcttcctcac tcagagctgc gatctctaag       60

attaagagag atgatgctgg tcagcaagtt tgtcccaatt atgtcatgct caggtcatcg      120

gtcacaacga aagtggtacg aaacgttgtt gagtatcaaa tccgtacagg tggattcttt      180

tcgtgcctag caatgttgag accgctccag tatgctaaac gtgaacgtct gcttggacaa      240

aggaatctgg aacgtatatc gactagggac attcttcaga cacgcgattt gcactcattg      300

tgcatgccaa ctcctgatgc gccaatgtcc aatcatcagg cagccaccat gagagagttg      360

atctgcagct atttcaaggt cgatcatgct gatgggttga aatatatacc catggatgag      420

agatattctc catcatcact tgccagactg tttaccatgg gtatggctgg cctccacatt      480

accactgagc cttcctacaa acgtgtgccc atcatgcact tagcggcaga tttggactgc      540

atgacgttgg ctctacccta tatgattaca cttgatggtg acacggtggt acctgttgcc      600

ccgacgcttt ctgcagaaca gcttttggat gatggactta aggggttagc ctgcatggat      660

atctcatacg gatgtgaggt ggacgctaat aaccgatcag ctggtgacca gagcatggat      720

tcttcacgat gcatcaatga gttatattgc gaggaaacgg cagaagctat ctgcgtactc      780

aaaacatgtc ttgtgctgaa ctgtatgcaa ttcaaacttg agatggatga tttagcacac      840

aatgctgctg agctggacaa gatacagatg atgatacctt ttagtgaacg cgtgttcaga      900

atggcttctg catttgctac cattgacgcc cagtgtttca ggttctgtgt gatgatgaag      960

gataagaatt tgaagataga tatgcgtgaa acgatgagac tttggactcg atcggcgctg     1020

gatgattcag tggctacgtc gtctttgagt atttcgctgg atcgaggtcg atgggtggca     1080

gctgatgcta atgatgctag gttgctggtg tttccaattc gcgtgtaatg ggtgagtaag     1140

ccgatgtggt cgccaaggca tgtgccggtg tcttggtggt gggtggcgcc taatcatc       1198


<210>  44
<211>  366
<212>  PRT
<213>  orthoreovirus

<400>  44

Met Ala Ser Ser Leu Arg Ala Ala Ile Ser Lys Ile Lys Arg Asp Asp 
1               5                   10                  15      


Ala Gly Gln Gln Val Cys Pro Asn Tyr Val Met Leu Arg Ser Ser Val 
            20                  25                  30          


Thr Thr Lys Val Val Arg Asn Val Val Glu Tyr Gln Ile Arg Thr Gly 
        35                  40                  45              


Gly Phe Phe Ser Cys Leu Ala Met Leu Arg Pro Leu Gln Tyr Ala Lys 
    50                  55                  60                  


Arg Glu Arg Leu Leu Gly Gln Arg Asn Leu Glu Arg Ile Ser Thr Arg 
65                  70                  75                  80  


Asp Ile Leu Gln Thr Arg Asp Leu His Ser Leu Cys Met Pro Thr Pro 
                85                  90                  95      


Asp Ala Pro Met Ser Asn His Gln Ala Ala Thr Met Arg Glu Leu Ile 
            100                 105                 110         


Cys Ser Tyr Phe Lys Val Asp His Ala Asp Gly Leu Lys Tyr Ile Pro 
        115                 120                 125             


Met Asp Glu Arg Tyr Ser Pro Ser Ser Leu Ala Arg Leu Phe Thr Met 
    130                 135                 140                 


Gly Met Ala Gly Leu His Ile Thr Thr Glu Pro Ser Tyr Lys Arg Val 
145                 150                 155                 160 


Pro Ile Met His Leu Ala Ala Asp Leu Asp Cys Met Thr Leu Ala Leu 
                165                 170                 175     


Pro Tyr Met Ile Thr Leu Asp Gly Asp Thr Val Val Pro Val Ala Pro 
            180                 185                 190         


Thr Leu Ser Ala Glu Gln Leu Leu Asp Asp Gly Leu Lys Gly Leu Ala 
        195                 200                 205             


Cys Met Asp Ile Ser Tyr Gly Cys Glu Val Asp Ala Asn Asn Arg Ser 
    210                 215                 220                 


Ala Gly Asp Gln Ser Met Asp Ser Ser Arg Cys Ile Asn Glu Leu Tyr 
225                 230                 235                 240 


Cys Glu Glu Thr Ala Glu Ala Ile Cys Val Leu Lys Thr Cys Leu Val 
                245                 250                 255     


Leu Asn Cys Met Gln Phe Lys Leu Glu Met Asp Asp Leu Ala His Asn 
            260                 265                 270         


Ala Ala Glu Leu Asp Lys Ile Gln Met Met Ile Pro Phe Ser Glu Arg 
        275                 280                 285             


Val Phe Arg Met Ala Ser Ala Phe Ala Thr Ile Asp Ala Gln Cys Phe 
    290                 295                 300                 


Arg Phe Cys Val Met Met Lys Asp Lys Asn Leu Lys Ile Asp Met Arg 
305                 310                 315                 320 


Glu Thr Met Arg Leu Trp Thr Arg Ser Ala Leu Asp Asp Ser Val Ala 
                325                 330                 335     


Thr Ser Ser Leu Ser Ile Ser Leu Asp Arg Gly Arg Trp Val Ala Ala 
            340                 345                 350         


Asp Ala Asn Asp Ala Arg Leu Leu Val Phe Pro Ile Arg Val 
        355                 360                 365     


<210>  45
<211>  1195
<212>  DNA
<213>  orthoreovirus

<400>  45
gctattttgc ctcttcctag acgttgtcgc aatggaggtg tgtctaccta atggtcatca       60

gatcgtcgac tggattaaca atgcatttga aggacgggtg tcgatttata gtgcacagca      120

aggatgggat aagacaatct cagctcagcc tgatatgatg gtgtgtggta gcgctgttgt      180

ttgcatgcat tgcttgggtg tggttggatc attacagcga aagttgaacc atctgcctca      240

tcataaatgt aatcagcaat tgcgtgagca ggattatgtt gacctacagt ttgctgatcg      300

tgtaaccgct cactggaaac gtggcatgtt atcatttgta tctcagatgc atgctatcat      360

gaacgatgtg acacctgagg agcttgaaag agtgagaact gatggtggca tcttggctga      420

gctcaactgg cttcaaatag agtctggatc aatgtttcgt tcgattcact caaactggac      480

tgaccccctt caggtggtcg aagacctaga tactcagcta gatcgctatt ggacagcatt      540

gaatttgatg attgattcat cggatctggt gccaaacttc atgatgcgtg acccatcgca      600

tgcctttaat ggagtgaagc tggagggtga agcgcgacag actcaattcc cgcgcacatt      660

cgattccggg tcaaacttga aatggggtgt tatggtatat gattattctg aacttgaagg      720

ggattctcag aaaggacgat cttataggag agagatcgtt actccagcga aagactttgg      780

tcactttggt ttatcccatt attctcgcgc aacgacgcca atacttggca agatgcctgc      840

tgtattttct ggtatgttaa ccgggaactg taaaatgtat ccgtttataa agggcactgc      900

taagctgaaa acggttaaga agctagttga tgctgtgaac tacacgtgga gttttgagaa      960

gatcagatac gctttaggcc ctggtgggat gacgggatgg tataatagaa ctatgcagca     1020

agcgccaatt gtgttgactc ctgcggcact gactatgttt ccggatatga ccagatttgg     1080

tgatctacag tatccaatca cgattggcga tccggctgtc cttgggtaaa cgcctccatc     1140

ttctcagcgc cgggcctgac caacctggtg tgacgtggga caggctccat tcatc          1195


<210>  46
<211>  365
<212>  PRT
<213>  orthoreovirus

<400>  46

Met Glu Val Cys Leu Pro Asn Gly His Gln Ile Val Asp Trp Ile Asn 
1               5                   10                  15      


Asn Ala Phe Glu Gly Arg Val Ser Ile Tyr Ser Ala Gln Gln Gly Trp 
            20                  25                  30          


Asp Lys Thr Ile Ser Ala Gln Pro Asp Met Met Val Cys Gly Ser Ala 
        35                  40                  45              


Val Val Cys Met His Cys Leu Gly Val Val Gly Ser Leu Gln Arg Lys 
    50                  55                  60                  


Leu Asn His Leu Pro His His Lys Cys Asn Gln Gln Leu Arg Glu Gln 
65                  70                  75                  80  


Asp Tyr Val Asp Leu Gln Phe Ala Asp Arg Val Thr Ala His Trp Lys 
                85                  90                  95      


Arg Gly Met Leu Ser Phe Val Ser Gln Met His Ala Ile Met Asn Asp 
            100                 105                 110         


Val Thr Pro Glu Glu Leu Glu Arg Val Arg Thr Asp Gly Gly Ile Leu 
        115                 120                 125             


Ala Glu Leu Asn Trp Leu Gln Ile Glu Ser Gly Ser Met Phe Arg Ser 
    130                 135                 140                 


Ile His Ser Asn Trp Thr Asp Pro Leu Gln Val Val Glu Asp Leu Asp 
145                 150                 155                 160 


Thr Gln Leu Asp Arg Tyr Trp Thr Ala Leu Asn Leu Met Ile Asp Ser 
                165                 170                 175     


Ser Asp Leu Val Pro Asn Phe Met Met Arg Asp Pro Ser His Ala Phe 
            180                 185                 190         


Asn Gly Val Lys Leu Glu Gly Glu Ala Arg Gln Thr Gln Phe Pro Arg 
        195                 200                 205             


Thr Phe Asp Ser Gly Ser Asn Leu Lys Trp Gly Val Met Val Tyr Asp 
    210                 215                 220                 


Tyr Ser Glu Leu Glu Gly Asp Ser Gln Lys Gly Arg Ser Tyr Arg Arg 
225                 230                 235                 240 


Glu Ile Val Thr Pro Ala Lys Asp Phe Gly His Phe Gly Leu Ser His 
                245                 250                 255     


Tyr Ser Arg Ala Thr Thr Pro Ile Leu Gly Lys Met Pro Ala Val Phe 
            260                 265                 270         


Ser Gly Met Leu Thr Gly Asn Cys Lys Met Tyr Pro Phe Ile Lys Gly 
        275                 280                 285             


Thr Ala Lys Leu Lys Thr Val Lys Lys Leu Val Asp Ala Val Asn Tyr 
    290                 295                 300                 


Thr Trp Ser Phe Glu Lys Ile Arg Tyr Ala Leu Gly Pro Gly Gly Met 
305                 310                 315                 320 


Thr Gly Trp Tyr Asn Arg Thr Met Gln Gln Ala Pro Ile Val Leu Thr 
                325                 330                 335     


Pro Ala Ala Leu Thr Met Phe Pro Asp Met Thr Arg Phe Gly Asp Leu 
            340                 345                 350         


Gln Tyr Pro Ile Thr Ile Gly Asp Pro Ala Val Leu Gly 
        355                 360                 365 


<210>  47
<211>  455
<212>  PRT
<213>  orthoreovirus

<400>  47

Met Asp Pro Arg Leu Arg Glu Glu Val Val Arg Leu Ile Ile Ala Leu 
1               5                   10                  15      


Thr Ser Asp Asn Gly Val Ser Leu Ser Lys Gly Leu Glu Ser Arg Val 
            20                  25                  30          


Ser Ala Leu Glu Lys Thr Ser Gln Ile His Ser Asp Thr Ile Leu Arg 
        35                  40                  45              


Ile Thr Gln Gly Leu Asp Asp Ala Asn Lys Arg Ile Ile Ala Leu Glu 
    50                  55                  60                  


Gln Ser Arg Asp Asp Leu Val Ala Ser Val Ser Asp Ala Gln Leu Ala 
65                  70                  75                  80  


Ile Ser Arg Leu Glu Ser Ser Ile Gly Ala Leu Gln Thr Val Val Asn 
                85                  90                  95      


Gly Leu Asp Ser Ser Val Thr Gln Leu Gly Ala Arg Val Gly Gln Leu 
            100                 105                 110         


Glu Thr Gly Leu Ala Glu Leu Arg Val Asp His Asp Asn Leu Val Ala 
        115                 120                 125             


Arg Val Asp Thr Ala Glu Arg Asn Ile Gly Ser Leu Thr Thr Glu Leu 
    130                 135                 140                 


Ser Thr Leu Thr Leu Arg Val Thr Ser Ile Gln Ala Asp Phe Glu Ser 
145                 150                 155                 160 


Arg Ile Ser Thr Leu Glu Arg Thr Ala Val Thr Ser Ala Gly Ala Pro 
                165                 170                 175     


Leu Ser Ile Arg Asn Asn Arg Met Thr Met Gly Leu Asn Asp Gly Leu 
            180                 185                 190         


Thr Leu Ser Gly Asn Asn Leu Ala Ile Arg Leu Pro Gly Asn Thr Gly 
        195                 200                 205             


Leu Asn Ile Gln Asn Gly Gly Leu Gln Phe Arg Phe Asn Thr Asp Gln 
    210                 215                 220                 


Phe Gln Ile Val Asn Asn Asn Leu Thr Leu Lys Thr Thr Val Phe Asp 
225                 230                 235                 240 


Ser Ile Asn Ser Arg Ile Gly Ala Thr Glu Gln Ser Tyr Val Ala Ser 
                245                 250                 255     


Ala Val Thr Pro Leu Arg Leu Asn Ser Ser Thr Lys Val Leu Asp Met 
            260                 265                 270         


Leu Ile Asp Ser Ser Thr Leu Glu Ile Asn Ser Ser Gly Gln Leu Thr 
        275                 280                 285             


Val Arg Ser Thr Ser Pro Asn Leu Arg Tyr Pro Ile Ala Asp Val Ser 
    290                 295                 300                 


Gly Gly Ile Gly Met Ser Pro Asn Tyr Arg Phe Arg Gln Ser Met Trp 
305                 310                 315                 320 


Ile Gly Ile Val Ser Tyr Ser Gly Ser Gly Leu Asn Trp Arg Val Gln 
                325                 330                 335     


Val Asn Ser Asp Ile Phe Ile Val Asp Asp Tyr Ile His Ile Cys Leu 
            340                 345                 350         


Pro Ala Phe Asp Gly Phe Ser Ile Ala Asp Gly Gly Asp Leu Ser Leu 
        355                 360                 365             


Asn Phe Val Thr Gly Leu Leu Pro Pro Leu Leu Thr Gly Asp Thr Glu 
    370                 375                 380                 


Pro Ala Phe His Asn Asp Val Val Thr Tyr Gly Ala Gln Thr Val Ala 
385                 390                 395                 400 


Ile Gly Leu Ser Ser Gly Gly Thr Pro Gln Tyr Met Ser Lys Asn Leu 
                405                 410                 415     


Trp Val Glu Gln Trp Gln Asp Gly Val Leu Arg Leu Arg Val Glu Gly 
            420                 425                 430         


Gly Gly Ser Ile Thr His Ser Asn Ser Lys Trp Pro Ala Met Thr Val 
        435                 440                 445             


Ser Tyr Pro Arg Ser Phe Thr 
    450                 455 


<210>  48
<211>  709
<212>  PRT
<213>  orthoreovirus

<400>  48

Met Gly Asn Ala Ser Ser Ile Val Gln Thr Ile Asn Val Thr Gly Asp 
1               5                   10                  15      


Gly Asn Val Phe Lys Pro Ser Ala Glu Thr Ser Ser Thr Ala Val Pro 
            20                  25                  30          


Ser Leu Ser Leu Ser Pro Gly Met Leu Asn Pro Gly Gly Val Pro Trp 
        35                  40                  45              


Ile Ala Val Gly Asp Glu Thr Ser Val Thr Ser Pro Gly Ala Leu Arg 
    50                  55                  60                  


Arg Met Thr Ser Lys Asp Ile Pro Glu Thr Ala Ile Ile Asn Thr Asp 
65                  70                  75                  80  


Asn Ser Ser Gly Ala Val Pro Ser Glu Ser Ala Leu Val Pro Tyr Ile 
                85                  90                  95      


Asp Glu Pro Leu Val Val Val Thr Glu His Ala Ile Thr Asn Phe Thr 
            100                 105                 110         


Lys Ala Glu Met Ala Leu Glu Phe Asn Arg Glu Phe Leu Asp Lys Met 
        115                 120                 125             


Arg Val Leu Ser Val Ser Pro Lys Tyr Ser Asp Leu Leu Ile Tyr Val 
    130                 135                 140                 


Asp Cys Tyr Val Gly Val Ser Ala Arg Gln Ala Leu Asn Asn Phe Gln 
145                 150                 155                 160 


Lys Gln Val Pro Val Ile Thr Pro Thr Arg Gln Thr Met Tyr Val Asp 
                165                 170                 175     


Ser Ile Gln Ala Ala Leu Lys Ala Leu Glu Lys Trp Glu Ile Asp Leu 
            180                 185                 190         


Arg Val Ala Gln Thr Leu Leu Pro Thr Asn Val Pro Ile Gly Glu Val 
        195                 200                 205             


Ser Cys Pro Met Gln Ser Val Val Lys Leu Leu Asp Asp Gln Leu Pro 
    210                 215                 220                 


Asp Asp Ser Leu Ile Arg Arg Tyr Pro Lys Glu Ala Ala Val Ala Leu 
225                 230                 235                 240 


Ala Lys Arg Asn Gly Gly Ile Gln Trp Met Asp Val Ser Glu Gly Thr 
                245                 250                 255     


Val Met Asn Glu Ala Val Asn Ala Val Ala Ala Ser Ala Leu Ala Pro 
            260                 265                 270         


Ser Ala Ser Ala Pro Pro Leu Glu Glu Lys Ser Lys Leu Thr Glu Gln 
        275                 280                 285             


Ala Met Asp Leu Val Thr Ala Ala Glu Pro Glu Ile Ile Ala Ser Leu 
    290                 295                 300                 


Ala Pro Val Pro Ala Pro Val Phe Ala Ile Pro Pro Lys Pro Ala Asp 
305                 310                 315                 320 


Tyr Asn Val Arg Thr Leu Arg Ile Asp Glu Ala Thr Trp Leu Arg Met 
                325                 330                 335     


Ile Pro Lys Ser Met Asn Thr Pro Phe Gln Ile Gln Val Thr Asp Asn 
            340                 345                 350         


Thr Gly Thr Asn Trp His Leu Asn Leu Arg Gly Gly Thr Arg Val Val 
        355                 360                 365             


Asn Leu Asp Gln Ile Ala Pro Met Arg Phe Val Leu Asp Leu Gly Gly 
    370                 375                 380                 


Lys Ser Tyr Lys Glu Thr Ser Trp Asp Pro Asn Gly Lys Lys Val Gly 
385                 390                 395                 400 


Phe Ile Val Phe Gln Ser Lys Ile Pro Phe Glu Leu Trp Thr Ala Ala 
                405                 410                 415     


Ser Gln Ile Gly Gln Ala Thr Val Val Asn Tyr Val Gln Leu Tyr Ala 
            420                 425                 430         


Glu Asp Ser Ser Phe Thr Arg Val Met Ser Ile Ile Ala Thr Thr Ser 
        435                 440                 445             


Leu Ala Tyr Asn Tyr Glu Pro Glu Gln Leu Asn Lys Thr Asp Pro Glu 
    450                 455                 460                 


Met Asn Tyr Tyr Leu Leu Ala Thr Phe Ile Asp Ser Ala Ala Ile Thr 
465                 470                 475                 480 


Pro Thr Asn Met Thr Gln Pro Asp Val Trp Asp Ala Leu Leu Thr Met 
                485                 490                 495     


Ser Pro Leu Ser Ala Gly Glu Val Thr Val Lys Gly Ala Val Val Ser 
            500                 505                 510         


Glu Val Val Pro Ala Asp Leu Ile Gly Ser Tyr Thr Pro Glu Ser Leu 
        515                 520                 525             


Asn Ala Ser Leu Pro Asn Asp Ala Ala Arg Cys Met Ile Asp Arg Ala 
    530                 535                 540                 


Ser Lys Ile Ala Glu Ala Ile Lys Ile Asp Asp Asp Ala Gly Pro Asp 
545                 550                 555                 560 


Glu Tyr Ser Pro Asn Ser Val Pro Ile Gln Gly Gln Leu Ala Ile Ser 
                565                 570                 575     


Gln Leu Glu Thr Gly Tyr Gly Val Arg Ile Phe Asn Pro Lys Gly Ile 
            580                 585                 590         


Leu Ser Lys Ile Ala Ser Arg Ala Met Gln Ala Phe Ile Gly Asp Pro 
        595                 600                 605             


Ser Thr Ile Ile Thr Gln Ala Ala Pro Val Leu Ser Asp Lys Asn Asn 
    610                 615                 620                 


Trp Ile Ala Leu Ala Gln Gly Val Lys Thr Ser Leu Arg Thr Lys Ser 
625                 630                 635                 640 


Leu Ser Ala Gly Val Lys Thr Ala Val Ser Lys Leu Ser Ser Ser Glu 
                645                 650                 655     


Ser Ile Gln Asn Trp Thr Gln Gly Phe Leu Asp Lys Val Ser Ala His 
            660                 665                 670         


Phe Pro Ala Pro Lys Pro Asp Cys Pro Thr Ser Gly Asp Ser Gly Glu 
        675                 680                 685             


Ser Ser Asn Arg Arg Val Lys Arg Asp Ser Tyr Ala Gly Val Val Lys 
    690                 695                 700                 


Arg Gly Tyr Thr Arg 
705                 


<210>  49
<211>  736
<212>  PRT
<213>  orthoreovirus

<400>  49

Met Ala Tyr Ile Ala Val Pro Ala Val Val Asp Ser Arg Ser Ser Glu 
1               5                   10                  15      


Ala Ile Gly Leu Leu Glu Ser Phe Gly Val Asp Ala Gly Ala Asp Ala 
            20                  25                  30          


Asn Asp Val Ser Tyr Gln Asp His Asp Tyr Val Leu Asp Gln Leu Gln 
        35                  40                  45              


Tyr Met Leu Asp Gly Tyr Glu Ala Gly Asp Val Ile Asp Ala Leu Val 
    50                  55                  60                  


His Lys Asn Trp Leu His His Ser Val Tyr Cys Leu Leu Pro Pro Lys 
65                  70                  75                  80  


Ser Gln Leu Leu Glu Tyr Trp Lys Ser Asn Pro Ser Ala Ile Pro Asp 
                85                  90                  95      


Asn Val Asp Arg Arg Leu Arg Lys Arg Leu Met Leu Lys Lys Asp Leu 
            100                 105                 110         


Arg Lys Asp Asp Glu Tyr Asn Gln Leu Val Arg Ala Phe Lys Ile Ser 
        115                 120                 125             


Asp Val Tyr Ala Pro Leu Ile Ser Ser Thr Thr Ser Pro Met Thr Met 
    130                 135                 140                 


Ile Gln Asn Leu Asn Gln Gly Glu Ile Val Tyr Thr Thr Thr Asp Arg 
145                 150                 155                 160 


Val Ile Gly Ala Arg Ile Leu Leu Tyr Ala Pro Arg Lys Tyr Tyr Ala 
                165                 170                 175     


Ser Thr Leu Ser Phe Thr Met Thr Lys Cys Ile Ile Pro Phe Gly Lys 
            180                 185                 190         


Glu Val Gly Arg Val Pro His Ser Arg Phe Asn Val Gly Thr Phe Ser 
        195                 200                 205             


Ser Ile Ala Thr Pro Lys Cys Phe Val Met Ser Gly Val Asp Ile Glu 
    210                 215                 220                 


Ser Ile Pro Asn Glu Phe Ile Lys Leu Phe Tyr Gln Arg Val Lys Ser 
225                 230                 235                 240 


Val His Ala Asn Ile Leu Asn Asp Ile Ser Pro Gln Ile Val Ser Asp 
                245                 250                 255     


Met Ile Asn Arg Lys Arg Leu Arg Val His Thr Pro Ser Asp Arg Arg 
            260                 265                 270         


Ala Ala Gln Leu Met His Leu Pro Tyr His Val Lys Arg Gly Ala Ser 
        275                 280                 285             


His Val Asp Val Tyr Lys Val Asp Val Val Asp Met Leu Phe Glu Val 
    290                 295                 300                 


Val Asp Val Ala Asp Gly Leu Arg Asn Val Ser Arg Lys Leu Thr Met 
305                 310                 315                 320 


His Thr Val Pro Val Cys Ile Leu Glu Met Leu Gly Ile Glu Ile Ala 
                325                 330                 335     


Asp Tyr Cys Ile Arg Gln Glu Asp Gly Met Leu Thr Asp Trp Phe Leu 
            340                 345                 350         


Leu Leu Thr Met Leu Ser Asp Gly Leu Thr Asp Arg Arg Thr His Cys 
        355                 360                 365             


Gln Tyr Leu Ile Asn Pro Ser Ser Val Pro Pro Asp Val Ile Leu Asn 
    370                 375                 380                 


Ile Ser Ile Thr Gly Phe Ile Asn Arg His Thr Ile Asp Val Met Pro 
385                 390                 395                 400 


Asp Ile Tyr Asp Phe Val Lys Pro Ile Gly Ala Val Leu Pro Lys Gly 
                405                 410                 415     


Ser Phe Lys Ser Thr Ile Met Arg Val Leu Asp Ser Ile Ser Ile Leu 
            420                 425                 430         


Gly Ile Gln Ile Met Pro Arg Ala His Val Val Asp Ser Asp Glu Val 
        435                 440                 445             


Gly Glu Gln Met Glu Pro Thr Phe Glu Gln Ala Val Met Glu Ile Tyr 
    450                 455                 460                 


Lys Gly Ile Ala Gly Val Asp Ser Leu Asp Asp Leu Ile Lys Trp Val 
465                 470                 475                 480 


Leu Asn Ser Asp Leu Ile Pro His Asp Asp Arg Leu Gly Gln Leu Phe 
                485                 490                 495     


Gln Ala Phe Leu Pro Leu Ala Lys Asp Leu Leu Ala Pro Met Ala Arg 
            500                 505                 510         


Lys Phe Tyr Asp Asn Ser Met Ser Glu Gly Arg Leu Leu Thr Phe Ala 
        515                 520                 525             


His Ala Asp Ser Glu Leu Leu Asn Ala Asn Tyr Phe Gly His Leu Leu 
    530                 535                 540                 


Arg Leu Lys Ile Pro Tyr Ile Thr Glu Val Asn Leu Met Ile Arg Lys 
545                 550                 555                 560 


Asn Arg Glu Gly Gly Glu Leu Phe Gln Leu Val Leu Ser Tyr Leu Tyr 
                565                 570                 575     


Lys Met Tyr Ala Thr Ser Ala Gln Pro Lys Trp Phe Gly Ser Leu Leu 
            580                 585                 590         


Arg Leu Leu Ile Cys Pro Trp Leu His Met Glu Lys Leu Ile Gly Glu 
        595                 600                 605             


Ala Asp Pro Ala Ser Thr Ser Ala Glu Ile Gly Trp His Ile Pro Arg 
    610                 615                 620                 


Glu Gln Leu Met Gln Asp Gly Trp Cys Gly Cys Glu Asp Gly Phe Ile 
625                 630                 635                 640 


Pro Tyr Val Ser Ile Arg Ala Pro Arg Leu Val Ile Glu Glu Leu Met 
                645                 650                 655     


Glu Lys Asn Trp Gly Gln Tyr His Ala Gln Val Ile Val Thr Asp Gln 
            660                 665                 670         


Leu Val Val Gly Glu Pro Arg Arg Val Ser Ala Lys Ala Val Ile Lys 
        675                 680                 685             


Gly Asn His Leu Pro Val Lys Leu Val Ser Arg Phe Ala Cys Phe Thr 
    690                 695                 700                 


Leu Thr Ala Lys Tyr Glu Met Arg Leu Ser Cys Gly His Ser Thr Gly 
705                 710                 715                 720 


Arg Gly Ala Ala Tyr Ser Ala Arg Leu Ala Phe Arg Ser Asp Leu Ala 
                725                 730                 735     


