                         SEQUENCE LISTING

<110>  UMC Utrecht Holding B.V.
 
<120>  selection of modified engineered T cells & depletion of 
       engineered lymphocytes

<130>  P32146EP00

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  272
<212>  PRT
<213>  homo sapiens

<400>  1

Met Glu Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Thr His 
1               5                   10                  15      


Leu Asp Cys Val Ser Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu 
            20                  25                  30          


His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Ser 
        35                  40                  45              


Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Trp Glu Thr Ala Lys Ser 
    50                  55                  60                  


Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys Lys 
65                  70                  75                  80  


Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu 
                85                  90                  95      


Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         


Arg Asn Thr Gly Asn Gln Phe Tyr Phe Gly Thr Gly Thr Ser Leu Thr 
        115                 120                 125             


Val Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
            180                 185                 190         


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
        195                 200                 205             


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
    210                 215                 220                 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


<210>  2
<211>  312
<212>  PRT
<213>  homo sapiens

<400>  2

Met Gly Ile Gly Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg 
                85                  90                  95      


Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Pro Val Thr Gly Gly Ile Tyr Gly Tyr Thr Phe Gly Ser Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Val Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val 
    130                 135                 140                 


Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
            180                 185                 190         


Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys 
        195                 200                 205             


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg 
    210                 215                 220                 


Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp 
225                 230                 235                 240 


Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala 
                245                 250                 255     


Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln 
            260                 265                 270         


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
        275                 280                 285             


Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met 
    290                 295                 300                 


Val Lys Arg Lys Asp Ser Arg Gly 
305                 310         


<210>  3
<211>  315
<212>  PRT
<213>  homo sapiens

<400>  3

Met Val Ser Leu Leu His Ala Ser Thr Leu Ala Val Leu Gly Ala Leu 
1               5                   10                  15      


Cys Val Tyr Gly Ala Gly His Leu Glu Gln Pro Gln Ile Ser Ser Thr 
            20                  25                  30          


Lys Thr Leu Ser Lys Thr Ala Arg Leu Glu Cys Val Val Ser Gly Ile 
        35                  40                  45              


Thr Ile Ser Ala Thr Ser Val Tyr Trp Tyr Arg Glu Arg Pro Gly Glu 
    50                  55                  60                  


Val Ile Gln Phe Leu Val Ser Ile Ser Tyr Asp Gly Thr Val Arg Lys 
65                  70                  75                  80  


Glu Ser Gly Ile Pro Ser Gly Lys Phe Glu Val Asp Arg Ile Pro Glu 
                85                  90                  95      


Thr Ser Thr Ser Thr Leu Thr Ile His Asn Val Glu Lys Gln Asp Ile 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Ala Leu Trp Glu Ala Gln Gln Glu Leu Gly Lys 
        115                 120                 125             


Lys Ile Lys Val Phe Gly Pro Gly Thr Lys Leu Ile Ile Thr Asp Lys 
    130                 135                 140                 


Gln Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu Pro Ser 
145                 150                 155                 160 


Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys Leu Leu 
                165                 170                 175     


Glu Lys Phe Phe Pro Asp Val Ile Lys Ile His Trp Glu Glu Lys Lys 
            180                 185                 190         


Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys Thr Asn 
        195                 200                 205             


Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Lys Ser Leu 
    210                 215                 220                 


Asp Lys Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys Asn Gly 
225                 230                 235                 240 


Val Asp Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val Ile Thr 
                245                 250                 255     


Met Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu 
            260                 265                 270         


Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu 
        275                 280                 285             


Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg 
    290                 295                 300                 


Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser 
305                 310                 315 


<210>  4
<211>  292
<212>  PRT
<213>  homo sapiens

<400>  4

Met Glu Arg Ile Ser Ser Leu Ile His Leu Ser Leu Phe Trp Ala Gly 
1               5                   10                  15      


Val Met Ser Ala Ile Glu Leu Val Pro Glu His Gln Thr Val Pro Val 
            20                  25                  30          


Ser Ile Gly Val Pro Ala Thr Leu Arg Cys Ser Met Lys Gly Glu Ala 
        35                  40                  45              


Ile Gly Asn Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr Gln Gly Asn Thr 
    50                  55                  60                  


Met Thr Phe Ile Tyr Arg Glu Lys Asp Ile Tyr Gly Pro Gly Phe Lys 
65                  70                  75                  80  


Asp Asn Phe Gln Gly Asp Ile Asp Ile Ala Lys Asn Leu Ala Val Leu 
                85                  90                  95      


Lys Ile Leu Ala Pro Ser Glu Arg Asp Glu Gly Ser Tyr Tyr Cys Ala 
            100                 105                 110         


Cys Asp Thr Leu Gly Met Gly Gly Glu Tyr Thr Asp Lys Leu Ile Phe 
        115                 120                 125             


Gly Lys Gly Thr Arg Val Thr Val Glu Pro Arg Ser Gln Pro His Thr 
    130                 135                 140                 


Lys Pro Ser Val Phe Val Met Lys Asn Gly Thr Asn Val Ala Cys Leu 
145                 150                 155                 160 


Val Lys Glu Phe Tyr Pro Lys Asp Ile Arg Ile Asn Leu Val Ser Ser 
                165                 170                 175     


Lys Lys Ile Thr Glu Phe Asp Pro Ala Ile Val Ile Ser Pro Ser Gly 
            180                 185                 190         


Lys Tyr Asn Ala Val Lys Leu Gly Lys Tyr Glu Asp Ser Asn Ser Val 
        195                 200                 205             


Thr Cys Ser Val Gln His Asp Asn Lys Thr Val His Ser Thr Asp Phe 
    210                 215                 220                 


Glu Val Lys Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu 
225                 230                 235                 240 


Asn Thr Lys Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val 
                245                 250                 255     


His Thr Glu Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg 
            260                 265                 270         


Met Leu Phe Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys 
        275                 280                 285             


Leu Phe Phe Leu 
    290         


<210>  5
<211>  306
<212>  PRT
<213>  mus musculus

<400>  5

Met Ala Thr Arg Leu Leu Cys Tyr Thr Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Arg Ile Leu Asn Ser Lys Val Ile Gln Thr Pro Arg Tyr Leu Val Lys 
            20                  25                  30          


Gly Gln Gly Gln Lys Ala Lys Met Arg Cys Ile Pro Glu Lys Gly His 
        35                  40                  45              


Pro Val Val Phe Trp Tyr Gln Gln Asn Lys Asn Asn Glu Phe Lys Phe 
    50                  55                  60                  


Leu Ile Asn Phe Gln Asn Gln Glu Val Leu Gln Gln Ile Asp Met Thr 
65                  70                  75                  80  


Glu Lys Arg Phe Ser Ala Glu Cys Pro Ser Asn Ser Pro Cys Ser Leu 
                85                  90                  95      


Glu Ile Gln Ser Ser Glu Ala Gly Asp Ser Ala Leu Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Ser Gly Gly Gly Thr Glu Val Phe Phe Gly Lys Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Val Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val 
    130                 135                 140                 


Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp 
            180                 185                 190         


Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg 
        195                 200                 205             


Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg 
    210                 215                 220                 


Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu 
225                 230                 235                 240 


Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly 
                245                 250                 255     


Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu 
            260                 265                 270         


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
        275                 280                 285             


Ala Val Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys 
    290                 295                 300                 


Asn Ser 
305     


<210>  6
<211>  306
<212>  PRT
<213>  mus musculus

<400>  6

Met Asn Lys Trp Val Phe Cys Trp Val Thr Leu Cys Leu Leu Thr Val 
1               5                   10                  15      


Glu Thr Thr His Gly Asp Gly Gly Ile Ile Thr Gln Thr Pro Lys Phe 
            20                  25                  30          


Leu Ile Gly Gln Glu Gly Gln Lys Leu Thr Leu Lys Cys Gln Gln Asn 
        35                  40                  45              


Phe Asn His Asp Thr Met Tyr Trp Tyr Arg Gln Asp Ser Gly Lys Gly 
    50                  55                  60                  


Leu Arg Leu Ile Tyr Tyr Ser Ile Thr Glu Asn Asp Leu Gln Lys Gly 
65                  70                  75                  80  


Asp Leu Ser Glu Gly Tyr Asp Ala Ser Arg Glu Lys Lys Ser Ser Phe 
                85                  90                  95      


Ser Leu Thr Val Thr Ser Ala Gln Lys Asn Glu Met Ala Val Phe Leu 
            100                 105                 110         


Cys Ala Ser Gly Asp Trp Gly Tyr Glu Gln Tyr Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val 
    130                 135                 140                 


Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp 
            180                 185                 190         


Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg 
        195                 200                 205             


Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg 
    210                 215                 220                 


Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu 
225                 230                 235                 240 


Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly 
                245                 250                 255     


Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu 
            260                 265                 270         


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
        275                 280                 285             


Ala Val Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys 
    290                 295                 300                 


Asn Ser 
305     


<210>  7
<211>  269
<212>  PRT
<213>  mus musculus

<400>  7

Met Val Leu Ala Leu Leu Pro Val Leu Gly Ile His Phe Val Leu Arg 
1               5                   10                  15      


Asp Ala Gln Ala Gln Ser Val Thr Gln Pro Asp Ala Arg Val Thr Val 
            20                  25                  30          


Ser Glu Gly Ala Ser Leu Gln Leu Arg Cys Lys Tyr Ser Tyr Ser Gly 
        35                  40                  45              


Thr Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Arg Gln Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Tyr Ser Gly Asp Pro Val Val Gln Gly Val Asn 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Ser Lys Ser Asn Ser Ser Phe His Leu Arg 
                85                  90                  95      


Lys Ala Ser Val His Trp Ser Asp Ser Ala Val Tyr Phe Cys Val Leu 
            100                 105                 110         


Ser Glu Asp Ser Asn Tyr Gln Leu Ile Trp Gly Ser Gly Thr Lys Leu 
        115                 120                 125             


Ile Ile Lys Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn 
            180                 185                 190         


Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile 
        195                 200                 205             


Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp 
    210                 215                 220                 


Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe 
225                 230                 235                 240 


Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala 
                245                 250                 255     


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 


<210>  8
<211>  268
<212>  PRT
<213>  mus musculus

<400>  8

Met Lys Arg Leu Leu Cys Ser Leu Leu Gly Leu Leu Cys Thr Gln Val 
1               5                   10                  15      


Cys Trp Val Lys Gly Gln Gln Val Gln Gln Ser Pro Ala Ser Leu Val 
            20                  25                  30          


Leu Gln Glu Gly Glu Asn Ala Glu Leu Gln Cys Asn Phe Ser Ser Thr 
        35                  40                  45              


Ala Thr Arg Leu Gln Trp Phe Tyr Gln Arg Pro Gly Gly Ser Leu Val 
    50                  55                  60                  


Ser Leu Leu Tyr Asn Pro Ser Gly Thr Lys His Thr Gly Arg Leu Thr 
65                  70                  75                  80  


Ser Thr Thr Val Thr Lys Glu Arg Arg Ser Ser Leu His Ile Ser Ser 
                85                  90                  95      


Ser Gln Thr Thr Asp Ser Gly Thr Tyr Phe Cys Ala Thr Ser Ser Val 
            100                 105                 110         


Asn Thr Gly Asn Tyr Lys Tyr Val Phe Gly Ala Gly Thr Arg Leu Lys 
        115                 120                 125             


Val Ile Ala His Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  9
<211>  141
<212>  PRT
<213>  homo sapiens

<400>  9

Asp Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys 
1               5                   10                  15      


Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr 
            20                  25                  30          


Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr 
        35                  40                  45              


Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala 
    50                  55                  60                  


Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser 
65                  70                  75                  80  


Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp 
                85                  90                  95      


Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe 
            100                 105                 110         


Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala 
        115                 120                 125             


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135                 140     


<210>  10
<211>  72
<212>  PRT
<213>  mus musculus

<400>  10

Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser 
1               5                   10                  15      


Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn 
            20                  25                  30          


Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Thr Val 
        35                  40                  45              


Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp 
    50                  55                  60                  


Ser Asn Gln Thr Ser Phe Thr Cys 
65                  70          


<210>  11
<211>  176
<212>  PRT
<213>  homo sapiens

<400>  11

Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser 
1               5                   10                  15      


Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala 
            20                  25                  30          


Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
        35                  40                  45              


Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu 
    50                  55                  60                  


Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg 
65                  70                  75                  80  


Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln 
                85                  90                  95      


Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg 
            100                 105                 110         


Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala 
        115                 120                 125             


Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala 
    130                 135                 140                 


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
145                 150                 155                 160 


Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe 
                165                 170                 175     


<210>  12
<211>  178
<212>  PRT
<213>  homo sapiens

<400>  12

Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser 
1               5                   10                  15      


Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala 
            20                  25                  30          


Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
        35                  40                  45              


Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu 
    50                  55                  60                  


Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg 
65                  70                  75                  80  


Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln 
                85                  90                  95      


Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg 
            100                 105                 110         


Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala 
        115                 120                 125             


Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala 
    130                 135                 140                 


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
145                 150                 155                 160 


Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Ser 
                165                 170                 175     


Arg Gly 
        


<210>  13
<211>  172
<212>  PRT
<213>  mus musculus

<400>  13

Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser 
1               5                   10                  15      


Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala 
            20                  25                  30          


Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
        35                  40                  45              


Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys Glu 
    50                  55                  60                  


Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr 
65                  70                  75                  80  


Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His 
                85                  90                  95      


Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val 
            100                 105                 110         


Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile 
        115                 120                 125             


Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr 
    130                 135                 140                 


Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr 
145                 150                 155                 160 


Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
                165                 170         


<210>  14
<211>  172
<212>  PRT
<213>  mus musculus

<400>  14

Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser 
1               5                   10                  15      


Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala 
            20                  25                  30          


Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
        35                  40                  45              


Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys Glu 
    50                  55                  60                  


Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr 
65                  70                  75                  80  


Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His 
                85                  90                  95      


Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val 
            100                 105                 110         


Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile 
        115                 120                 125             


Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr 
    130                 135                 140                 


Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Gly 
145                 150                 155                 160 


Leu Val Leu Met Ala Met Val Lys Lys Lys Asn Ser 
                165                 170         


<210>  15
<211>  177
<212>  PRT
<213>  homo sapiens

<400>  15

Pro Ser Tyr Thr Gly Gly Tyr Ala Asp Lys Leu Ile Phe Gly Lys Gly 
1               5                   10                  15      


Thr Arg Val Thr Val Glu Pro Arg Ser Gln Pro His Thr Lys Pro Ser 
            20                  25                  30          


Val Phe Val Met Lys Asn Gly Thr Asn Val Ala Cys Leu Val Lys Glu 
        35                  40                  45              


Phe Tyr Pro Lys Asp Ile Arg Ile Asn Leu Val Ser Ser Lys Lys Ile 
    50                  55                  60                  


Thr Glu Phe Asp Pro Ala Ile Val Ile Ser Pro Ser Gly Lys Tyr Asn 
65                  70                  75                  80  


Ala Val Lys Leu Gly Lys Tyr Glu Asp Ser Asn Ser Val Thr Cys Ser 
                85                  90                  95      


Val Gln His Asp Asn Lys Thr Val His Ser Thr Asp Phe Glu Val Lys 
            100                 105                 110         


Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys 
        115                 120                 125             


Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu 
    130                 135                 140                 


Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe 
145                 150                 155                 160 


Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe 
                165                 170                 175     


Leu 
    


<210>  16
<211>  152
<212>  PRT
<213>  mus musculus

<400>  16

Ser Gln Pro Pro Ala Lys Pro Ser Val Phe Ile Met Lys Asn Gly Thr 
1               5                   10                  15      


Asn Val Ala Cys Leu Val Lys Asp Phe Tyr Pro Lys Glu Val Thr Ile 
            20                  25                  30          


Ser Leu Arg Ser Ser Lys Lys Ile Val Glu Phe Asp Pro Ala Ile Val 
        35                  40                  45              


Ile Ser Pro Ser Gly Lys Tyr Ser Ala Val Lys Leu Gly Gln Tyr Gly 
    50                  55                  60                  


Asp Ser Asn Ser Val Thr Cys Ser Val Gln His Asn Ser Glu Thr Val 
65                  70                  75                  80  


His Ser Thr Asp Phe Glu Pro Tyr Ala Asn Ser Phe Asn Asn Glu Lys 
                85                  90                  95      


Leu Pro Glu Pro Glu Asn Asp Thr Gln Ile Ser Glu Pro Cys Tyr Gly 
            100                 105                 110         


Pro Arg Val Thr Val His Thr Glu Lys Val Asn Met Met Ser Leu Thr 
        115                 120                 125             


Val Leu Gly Leu Arg Leu Leu Phe Ala Lys Thr Ile Ala Ile Asn Phe 
    130                 135                 140                 


Leu Leu Thr Val Lys Leu Phe Phe 
145                 150         


<210>  17
<211>  172
<212>  PRT
<213>  homo sapiens

<400>  17

Lys Gln Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu Pro 
1               5                   10                  15      


Ser Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys Leu 
            20                  25                  30          


Leu Glu Lys Phe Phe Pro Asp Val Ile Lys Ile His Trp Gln Glu Lys 
        35                  40                  45              


Lys Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys Thr 
    50                  55                  60                  


Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Lys Ser 
65                  70                  75                  80  


Leu Asp Lys Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys Asn 
                85                  90                  95      


Gly Val Asp Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val Ile 
            100                 105                 110         


Thr Met Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu 
        115                 120                 125             


Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu 
    130                 135                 140                 


Leu Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu 
145                 150                 155                 160 


Arg Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser 
                165                 170         


<210>  18
<211>  109
<212>  PRT
<213>  homo sapiens

<400>  18

Lys Gln Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu Pro 
1               5                   10                  15      


Ser Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys Leu 
            20                  25                  30          


Leu Glu Lys Phe Phe Pro Asp Ile Ile Lys Ile His Trp Gln Glu Lys 
        35                  40                  45              


Lys Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys Thr 
    50                  55                  60                  


Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Glu Ser 
65                  70                  75                  80  


Leu Asp Lys Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys Asn 
                85                  90                  95      


Gly Ile Asp Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr 
            100                 105                 


<210>  19
<211>  204
<212>  PRT
<213>  homo sapiens

<400>  19

Lys Gln Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu Pro 
1               5                   10                  15      


Ser Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys Leu 
            20                  25                  30          


Leu Glu Lys Phe Phe Pro Asp Ile Ile Lys Ile His Trp Gln Glu Lys 
        35                  40                  45              


Lys Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys Thr 
    50                  55                  60                  


Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Glu Ser 
65                  70                  75                  80  


Leu Asp Lys Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys Asn 
                85                  90                  95      


Gly Ile Asp Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val Thr 
            100                 105                 110         


Thr Val Asp Pro Lys Asp Ser Tyr Ser Lys Asp Ala Asn Asp Val Thr 
        115                 120                 125             


Thr Val Asp Pro Lys Tyr Asn Tyr Ser Lys Asp Ala Asn Asp Val Ile 
    130                 135                 140                 


Thr Met Asp Pro Lys Asp Asn Trp Ser Lys Asp Ala Asn Asp Thr Leu 
145                 150                 155                 160 


Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu 
                165                 170                 175     


Leu Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu 
            180                 185                 190         


Gly Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser 
        195                 200                 


<210>  20
<211>  171
<212>  PRT
<213>  mus musculus

<400>  20

Lys Arg Leu Asp Ala Asp Ile Ser Pro Lys Pro Thr Ile Phe Leu Pro 
1               5                   10                  15      


Ser Val Ala Glu Thr Asn Leu His Lys Thr Gly Thr Tyr Leu Cys Leu 
            20                  25                  30          


Leu Glu Lys Phe Phe Pro Asp Val Ile Arg Val Tyr Trp Lys Glu Lys 
        35                  40                  45              


Asp Gly Asn Thr Ile Leu Asp Ser Gln Glu Gly Asp Thr Leu Lys Thr 
    50                  55                  60                  


Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Arg Ala 
65                  70                  75                  80  


Met Gly Lys Glu His Arg Cys Ile Val Lys His Glu Asn Asn Lys Gly 
                85                  90                  95      


Gly Ala Asp Gln Glu Ile Phe Phe Pro Ser Ile Lys Lys Val Ala Val 
            100                 105                 110         


Ser Thr Lys Pro Thr Thr Cys Trp Gln Asp Lys Asn Asp Val Leu Gln 
        115                 120                 125             


Leu Gln Phe Thr Ile Thr Ser Ala Tyr Tyr Thr Tyr Leu Leu Leu Leu 
    130                 135                 140                 


Leu Lys Ser Val Ile Tyr Leu Ala Ile Ile Ser Phe Ser Leu Leu Arg 
145                 150                 155                 160 


Arg Thr Ser Val Cys Gly Asn Glu Lys Lys Ser 
                165                 170     


<210>  21
<211>  166
<212>  PRT
<213>  mus musculus

<400>  21

Lys Arg Leu Asp Ala Asp Ile Ser Pro Lys Pro Thr Ile Phe Leu Pro 
1               5                   10                  15      


Ser Val Ala Glu Thr Asn Leu His Lys Thr Gly Thr Tyr Leu Cys Leu 
            20                  25                  30          


Leu Glu Lys Phe Phe Pro Asp Val Ile Arg Val Tyr Trp Lys Glu Lys 
        35                  40                  45              


Asn Gly Asn Thr Ile Leu Asp Ser Gln Glu Gly Asp Thr Leu Lys Thr 
    50                  55                  60                  


Lys Gly Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Arg Ala 
65                  70                  75                  80  


Met Gly Lys Glu His Ser Cys Ile Val Lys His Glu Asn Asn Lys Gly 
                85                  90                  95      


Gly Ala Asp Gln Glu Ile Phe Phe Pro Ser Ile Lys Lys Val Ala Thr 
            100                 105                 110         


Thr Cys Trp Gln Asp Lys Asn Asp Val Leu Gln Phe Gln Phe Thr Ser 
        115                 120                 125             


Thr Ser Ala Tyr Tyr Thr Tyr Leu Leu Leu Leu Leu Lys Ser Val Ile 
    130                 135                 140                 


Tyr Leu Ala Ile Ile Ser Phe Ser Leu Leu Arg Arg Thr Ser Val Cys 
145                 150                 155                 160 


Gly Asn Glu Lys Lys Ser 
                165     


<210>  22
<211>  171
<212>  PRT
<213>  mus musculus

<400>  22

Lys Lys Leu Asp Ala Asp Ile Ser Pro Lys Pro Thr Ile Phe Leu Pro 
1               5                   10                  15      


Ser Val Ala Glu Thr Asn Leu His Lys Thr Gly Thr Tyr Leu Cys Val 
            20                  25                  30          


Leu Glu Lys Phe Phe Pro Asp Val Ile Arg Val Tyr Trp Lys Glu Lys 
        35                  40                  45              


Lys Gly Asn Thr Ile Leu Asp Ser Gln Glu Gly Asp Met Leu Lys Thr 
    50                  55                  60                  


Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Arg Ser 
65                  70                  75                  80  


Met Gly Lys Glu His Arg Cys Ile Val Lys His Glu Asn Asn Lys Gly 
                85                  90                  95      


Gly Ala Asp Gln Glu Ile Phe Phe Pro Thr Ile Lys Lys Val Ala Val 
            100                 105                 110         


Ser Thr Lys Pro Thr Thr Cys Trp Gln Asp Lys Asn Asp Val Leu Gln 
        115                 120                 125             


Leu Gln Phe Thr Ile Thr Ser Ala Tyr Tyr Thr Tyr Leu Leu Leu Leu 
    130                 135                 140                 


Leu Lys Ser Val Ile Tyr Leu Ala Ile Ile Ser Phe Ser Leu Leu Arg 
145                 150                 155                 160 


Arg Thr Ser Val Cys Cys Asn Glu Lys Lys Ser 
                165                 170     


<210>  23
<211>  166
<212>  PRT
<213>  mus musculus

<400>  23

Lys Arg Leu Asp Ala Asp Ile Ser Pro Lys Pro Thr Ile Phe Leu Pro 
1               5                   10                  15      


Ser Val Ala Glu Thr Asn Leu His Lys Thr Gly Thr Tyr Leu Cys Leu 
            20                  25                  30          


Leu Glu Lys Phe Phe Pro Asp Val Ile Arg Val Tyr Trp Lys Glu Lys 
        35                  40                  45              


Asn Gly Asn Thr Ile Leu Asp Ser Gln Glu Gly Asp Thr Leu Lys Thr 
    50                  55                  60                  


Lys Gly Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Arg Ala 
65                  70                  75                  80  


Met Gly Lys Glu His Ser Cys Ile Val Lys His Glu Asn Asn Lys Gly 
                85                  90                  95      


Gly Ala Asp Gln Glu Ile Phe Phe Pro Ser Ile Lys Lys Val Ala Thr 
            100                 105                 110         


Thr Cys Trp Gln Asp Lys Asn Asp Val Leu Gln Phe Gln Phe Thr Ser 
        115                 120                 125             


Thr Ser Ala Tyr Tyr Thr Tyr Leu Leu Leu Leu Leu Lys Ser Val Ile 
    130                 135                 140                 


Tyr Leu Ala Ile Ile Ser Phe Ser Leu Leu Arg Arg Thr Ser Val Cys 
145                 150                 155                 160 


Gly Asn Glu Lys Lys Ser 
                165     


