﻿               SEQUENCE LISTING

<110> CeMM Forschungszentrum für Molekulare Medizin GmbH

<120> Antagonist of Setdb2 for use in the therapy of infectious diseases

<130> X1050 PCT S3

<150> EP14 19 4146.8
<151> 2014-11-20

<160> 19

<170> BiSSAP 1.3

<210> 1
<211> 6236
<212> DNA
<213> Homo sapiens

<400> 1
atccccggta gaggcagggc gggactgttg tggttgagat gaaggctagt aaatggtgaa       60

gtacttcccg gccagagggc acctgcgctc gggaggtttg ggcggcttgg cgtcggagga      120

gagccccacc cgcggaggaa cccagccttg ccaacggagc tggcggagct cactcctcag      180

gtcaggcggg cggcgtagaa aacgcagcgg agccaggtga aaccaaggca ccgccgtggc      240

tggcccccga cagttcctct agccgggagg ttggaggagc tgaaaacgcc gcggagccct      300

cggccgcccg agcaggggct ggaccccagc ccttgcagcc tcccttctcc tggcacccaa      360

gtgcagtcct ggctgcagaa ggggccgcgg gcgcactgag tttccaacct ccatttcagc      420

ctgtctgtct cagggtgcag ccttaatgag aggtgattcc taagctgctg ggaacctgag      480

gttgtcaaag gggcggcagg aaatggacag cagtataaaa cccagaagca gaacttgaag      540

gttaaaccac tagcccattt cacagaatgt ttcatccatt tgtggaccaa aagatggagt      600

tggtttttat ttttaaaaag ataatgttaa tgatctgata ccactacaaa tatttacgtg      660

agaagattca tggacttgtc ttttggttgg actgtcactc atttctgaaa gtttcttcag      720

ccacaatttc tatttgaaaa ttcaagtatc aaaggatacc aggtttagaa tggtataatg      780

atgtattttg tctgaggact gcaaatttta tagagaccac agttggattc cagtgatatt      840

ctgcaatcaa agtgatttga taaacctaat tttgaagcat tttatattta taagcgacat      900

caaaagatgg gagaaaaaaa tggcgatgca aaaactttct ggatggagct agaagatgat      960

ggaaaagtgg acttcatttt tgaacaagta caaaatgtgc tgcagtcact gaaacaaaag     1020

atcaaagatg ggtctgccac caataaagaa tacatccaag caatgattct agtgaatgaa     1080

gcaactataa ttaacagttc aacatcaata aagggagcat cacagaaaga agtgaatgcc     1140

caaagcagtg atcctatgcc tgtgactcag aaggaacagg aaaacaaatc caatgcattt     1200

ccctctacat catgtgaaaa ctcctttcca gaagactgta catttctaac aacagaaaat     1260

aaggaaattc tctctcttga agataaagtt gtagacttta gagaaaaaga ctcatcttcg     1320

aatttatctt accaaagtca tgactgctct ggtgcttgtc tgatgaaaat gccactgaac     1380

ttgaagggag aaaaccctct gcagctgcca atcaaatgtc acttccaaag acgacatgca     1440

aagacaaact ctcattcttc agcactccac gtgagttata aaaccccttg tggaaggagt     1500

ctacgaaacg tggaggaagt ttttcgttac ctgcttgaga cagagtgtaa ctttttattt     1560

acagataact tttctttcaa tacctatgtt cagttggctc ggaattaccc aaagcaaaaa     1620

gaagttgttt ctgatgtgga tattagcaat ggagtggaat cagtgcccat ttctttctgt     1680

aatgaaattg acagtagaaa gctcccacag tttaagtaca gaaagactgt gtggcctcga     1740

gcatataatc taaccaactt ttccagcatg tttactgatt cctgtgactg ctctgagggc     1800

tgcatagaca taacaaaatg tgcatgtctt caactgacag caaggaatgc caaaacttcc     1860

cccttgtcaa gtgacaaaat aaccactgga tataaatata aaagactaca gagacagatt     1920

cctactggca tttatgaatg cagccttttg tgcaaatgta atcgacaatt gtgtcaaaac     1980

cgagttgtcc aacatggtcc tcaagtgagg ttacaggtgt tcaaaactga gcagaaggga     2040

tggggtgtac gctgtctaga tgacattgac agagggacat ttgtttgcat ttattcagga     2100

agattactaa gcagagctaa cactgaaaaa tcttatggta ttgatgaaaa cgggagagat     2160

gagaatacta tgaaaaatat attttcaaaa aagaggaaat tagaagttgc atgttcagat     2220

tgtgaagttg aagttctccc attaggattg gaaacacatc ctagaactgc taaaactgag     2280

aaatgtccac caaagttcag taataatccc aaggagctta ctgtggaaac gaaatatgat     2340

aatatttcaa gaattcaata tcattcagtt attagagatc ctgaatccaa gacagccatt     2400

tttcaacaca atgggaaaaa aatggaattt gtttcctcgg agtctgtcac tccagaagat     2460

aatgatggat ttaaaccacc ccgagagcat ctgaactcta aaaccaaggg agcacaaaag     2520

gactcaagtt caaaccatgt tgatgagttt gaagataatc tgctgattga atcagatgtg     2580

atagatataa ctaaatatag agaagaaact ccaccaagga gcagatgtaa ccaggcgacc     2640

acattggata atcagaatat taaaaaggca attgaggttc aaattcagaa accccaagag     2700

ggacgatcta cagcatgtca aagacagcag gtattttgtg atgaagagtt gctaagtgaa     2760

accaagaata cttcatctga ttctctaaca aagttcaata aagggaatgt gtttttattg     2820

gatgccacaa aagaaggaaa tgtcggccgc ttccttaatc atagttgttg cccaaatctc     2880

ttggtacaga atgtttttgt agaaacacac aacaggaatt ttccattggt ggcattcttc     2940

accaacaggt atgtgaaagc aagaacagag ctaacatggg attatggcta tgaagctggg     3000

actgtgcctg agaaggaaat cttctgccaa tgtggggtta ataaatgtag aaaaaaaata     3060

ttataaatat gtaactaacg cctgtttgtg aaattagctt atcaggctga aattaaagcc     3120

atgcaaaaga aggtctaggt ccatcaagga aattcccctc cgttttcctt tgtcatgggg     3180

tttatgtttt atttcagatt ttatttgtgt gacttagaaa ttccaggaac acaattagga     3240

tattttcata cacatagggt atcttgttca ctgctgtgct actttacatg agtaggatgg     3300

aagtgtatat tttatatgaa ataccactgt acaatttata atttatttac aaattatata     3360

ttaagagaaa caaatgtcat aacagaactc agctgtttct aattgctttt gtgactgtta     3420

ccttttagtt catgcccccc caaagagcta aatttcacat ttttacctac aaaattgatt     3480

tttaattcct ggcaaataat ttaccattat gagctacaag gtgggcaaca gcgcctgagg     3540

atctaatttt atgcatatta ctcccaagta ttttaacact tgttggagaa gcaatatctg     3600

gatcgataaa acactgtccc atcaaccatt tgagtgggga gagggagaag ctcttctgta     3660

agtaagattc tggcaagctc tttgaaatga gtcttctttc ccacagattt tctctactct     3720

ttctatacaa acagatagga gaagagggaa tagaaacctg gaggaacttg aatatttttg     3780

ttctagatag agatacagtt actgaaaagg aaacctagaa agtagtcaca cgttgcttat     3840

ttaggccaga agtaattgta ctgggcaaaa atttcactta aaaaacacaa gaagtccagg     3900

tatggtggct cagacctgta atcccagcac tttgagaggc cgaggcaggt ggattacttg     3960

agcctagggg ttcaagacca gcttgggcaa catgtcaaaa ccctgtctct acaaaaaata     4020

caaaaattag cctggcatga tggcatgtgc ccgtagtctc agctactcag gagtgaggtg     4080

ggaggatcat ttgagctcag aaggtcaagg ctgcaatgag acataatttc accatagtac     4140

ttccagcctg ggcaatagag caagactctc tctcaaaaaa aacagcacac acacacacac     4200

acgaaaacaa ttctgaacta tgaaatctga aacagcccct tggtatctcc tgggcatgat     4260

ttgcaaatct ttttttttta cagaaaaaag gcaaagagta agcactttgc cataggttac     4320

ttggccgtga tcatctatct agtggaaaag gggactggga agcccaagca gactgggaaa     4380

ccagacagct aggaaaagga gcaaaacata gcccagcaac ctacagatga agaaagttga     4440

gaaatccatt tattcaccat agagacgcag gaatttcagg caatgcacta aaatgaaatg     4500

ggggaaaaaa gcttgatcag tatgggaacc atttttgtgc aaaagggaat attatggatc     4560

agccagtatt tctttgagct ctgcctgtgg agtccatttg acctttagaa atatgaggta     4620

ttctgtcagt tttatcttct tggagaaatt tctcctaaaa tcttgatttg ctttagtctg     4680

gactggttca tagccatcat cttccatcag taccccagag attcactttg tctcttatgt     4740

gggatctgtt tccagttaga tgccattatt ttccttttcc ttggtttact cttccacata     4800

ttggtaaagc tcttccaata gcttttggaa aggaaaaatg aaaagtaaat gttttgaatc     4860

tctgtgtgtt tgacaatgtc tttattttac ccttatacct gattgctgtt ttggttggca     4920

aggtatagga ttctttagtg gtctccatgc ccagttttga agacatctgc tagctttcag     4980

tgctgttgct gtggagtctg aaaatctgtc ttctggcttc cagggtgact actggaaatt     5040

gaatgccatt ctgttccttc tcttttgcat atataatcca tttttatctc tcttgaagct     5100

tataggttta tctttgtctc aatgttctgt ccctgttaag agtccatttt catcctttgt     5160

actaggtgcc tggtgggatc attccgtctg aaactaatga tttcccatct cttcactgtt     5220

tctggaattc ctgttttcca gatgttagac ctccagaatt tgatctctaa ttttcctatc     5280

ttttctctta actttcagct ctgtcttctt gctaggacct tttcctagga gcatttctca     5340

atttaatctt ccagttcatc tgttgcattt tatttttcta gtctcatatt gtctcatatt     5400

tttaatttct aagagctccc cttctccgaa tattcttttt ttttaatagc atcctatttt     5460

ggctcatggt tgcagtattt tatctccttg aagatgtttg tgtgtttatg tatgtatatg     5520

cacacacgta tacatacaca tacaggcatg catctctgta ttctttcggc ataatctgtg     5580

tcctccaggg tttgtttctt tgtttcccct gtatgtttgt tttggtcgtt cacattatag     5640

gctttcctca gagttaatgg tcttggtagt ctactcatat ttaagtgtgg aacaccaaaa     5700

agcttactat aagctgagag tgtggtaaag ggctctttgt tttactatga cctacctgag     5760

ctatcttgct ggggaacacc ctaatgtcag tctctttata aagggccttt cattttggcc     5820

tggcaagaaa tactctttca tcctcctgca tggagggcaa aaaaaaattt aaaaattggc     5880

tgctagggtc tgtctgctca cttccctgtt ttgcagaccc cacactcttc tgcaattcat     5940

ttcatagttg tcaagactat acaaattgtc ctttttaatg ttctctcttc tgctatccct     6000

agttggcagt cttcctcttt acaacctgct gaaagtggaa gacctccagt tttcctttaa     6060

ttcctcagca aaccaccaac tattatatgt cttttttcca gaacaactta ttttttaact     6120

ataattatat gcatttatgt tagattcact gaaaacctca tcttgtatgg tgctctgtac     6180

cctatgggtg ctaaataaag gcttgctact ggcaactgga aaaaaaaaaa aaaaaa         6236


<210> 2
<211> 719
<212> PRT
<213> Homo sapiens

<400> 2
Met Gly Glu Lys Asn Gly Asp Ala Lys Thr Phe Trp Met Glu Leu Glu 
1               5                   10                  15      
Asp Asp Gly Lys Val Asp Phe Ile Phe Glu Gln Val Gln Asn Val Leu 
            20                  25                  30          
Gln Ser Leu Lys Gln Lys Ile Lys Asp Gly Ser Ala Thr Asn Lys Glu 
        35                  40                  45              
Tyr Ile Gln Ala Met Ile Leu Val Asn Glu Ala Thr Ile Ile Asn Ser 
    50                  55                  60                  
Ser Thr Ser Ile Lys Gly Ala Ser Gln Lys Glu Val Asn Ala Gln Ser 
65                  70                  75                  80  
Ser Asp Pro Met Pro Val Thr Gln Lys Glu Gln Glu Asn Lys Ser Asn 
                85                  90                  95      
Ala Phe Pro Ser Thr Ser Cys Glu Asn Ser Phe Pro Glu Asp Cys Thr 
            100                 105                 110         
Phe Leu Thr Thr Glu Asn Lys Glu Ile Leu Ser Leu Glu Asp Lys Val 
        115                 120                 125             
Val Asp Phe Arg Glu Lys Asp Ser Ser Ser Asn Leu Ser Tyr Gln Ser 
    130                 135                 140                 
His Asp Cys Ser Gly Ala Cys Leu Met Lys Met Pro Leu Asn Leu Lys 
145                 150                 155                 160 
Gly Glu Asn Pro Leu Gln Leu Pro Ile Lys Cys His Phe Gln Arg Arg 
                165                 170                 175     
His Ala Lys Thr Asn Ser His Ser Ser Ala Leu His Val Ser Tyr Lys 
            180                 185                 190         
Thr Pro Cys Gly Arg Ser Leu Arg Asn Val Glu Glu Val Phe Arg Tyr 
        195                 200                 205             
Leu Leu Glu Thr Glu Cys Asn Phe Leu Phe Thr Asp Asn Phe Ser Phe 
    210                 215                 220                 
Asn Thr Tyr Val Gln Leu Ala Arg Asn Tyr Pro Lys Gln Lys Glu Val 
225                 230                 235                 240 
Val Ser Asp Val Asp Ile Ser Asn Gly Val Glu Ser Val Pro Ile Ser 
                245                 250                 255     
Phe Cys Asn Glu Ile Asp Ser Arg Lys Leu Pro Gln Phe Lys Tyr Arg 
            260                 265                 270         
Lys Thr Val Trp Pro Arg Ala Tyr Asn Leu Thr Asn Phe Ser Ser Met 
        275                 280                 285             
Phe Thr Asp Ser Cys Asp Cys Ser Glu Gly Cys Ile Asp Ile Thr Lys 
    290                 295                 300                 
Cys Ala Cys Leu Gln Leu Thr Ala Arg Asn Ala Lys Thr Ser Pro Leu 
305                 310                 315                 320 
Ser Ser Asp Lys Ile Thr Thr Gly Tyr Lys Tyr Lys Arg Leu Gln Arg 
                325                 330                 335     
Gln Ile Pro Thr Gly Ile Tyr Glu Cys Ser Leu Leu Cys Lys Cys Asn 
            340                 345                 350         
Arg Gln Leu Cys Gln Asn Arg Val Val Gln His Gly Pro Gln Val Arg 
        355                 360                 365             
Leu Gln Val Phe Lys Thr Glu Gln Lys Gly Trp Gly Val Arg Cys Leu 
    370                 375                 380                 
Asp Asp Ile Asp Arg Gly Thr Phe Val Cys Ile Tyr Ser Gly Arg Leu 
385                 390                 395                 400 
Leu Ser Arg Ala Asn Thr Glu Lys Ser Tyr Gly Ile Asp Glu Asn Gly 
                405                 410                 415     
Arg Asp Glu Asn Thr Met Lys Asn Ile Phe Ser Lys Lys Arg Lys Leu 
            420                 425                 430         
Glu Val Ala Cys Ser Asp Cys Glu Val Glu Val Leu Pro Leu Gly Leu 
        435                 440                 445             
Glu Thr His Pro Arg Thr Ala Lys Thr Glu Lys Cys Pro Pro Lys Phe 
    450                 455                 460                 
Ser Asn Asn Pro Lys Glu Leu Thr Val Glu Thr Lys Tyr Asp Asn Ile 
465                 470                 475                 480 
Ser Arg Ile Gln Tyr His Ser Val Ile Arg Asp Pro Glu Ser Lys Thr 
                485                 490                 495     
Ala Ile Phe Gln His Asn Gly Lys Lys Met Glu Phe Val Ser Ser Glu 
            500                 505                 510         
Ser Val Thr Pro Glu Asp Asn Asp Gly Phe Lys Pro Pro Arg Glu His 
        515                 520                 525             
Leu Asn Ser Lys Thr Lys Gly Ala Gln Lys Asp Ser Ser Ser Asn His 
    530                 535                 540                 
Val Asp Glu Phe Glu Asp Asn Leu Leu Ile Glu Ser Asp Val Ile Asp 
545                 550                 555                 560 
Ile Thr Lys Tyr Arg Glu Glu Thr Pro Pro Arg Ser Arg Cys Asn Gln 
                565                 570                 575     
Ala Thr Thr Leu Asp Asn Gln Asn Ile Lys Lys Ala Ile Glu Val Gln 
            580                 585                 590         
Ile Gln Lys Pro Gln Glu Gly Arg Ser Thr Ala Cys Gln Arg Gln Gln 
        595                 600                 605             
Val Phe Cys Asp Glu Glu Leu Leu Ser Glu Thr Lys Asn Thr Ser Ser 
    610                 615                 620                 
Asp Ser Leu Thr Lys Phe Asn Lys Gly Asn Val Phe Leu Leu Asp Ala 
625                 630                 635                 640 
Thr Lys Glu Gly Asn Val Gly Arg Phe Leu Asn His Ser Cys Cys Pro 
                645                 650                 655     
Asn Leu Leu Val Gln Asn Val Phe Val Glu Thr His Asn Arg Asn Phe 
            660                 665                 670         
Pro Leu Val Ala Phe Phe Thr Asn Arg Tyr Val Lys Ala Arg Thr Glu 
        675                 680                 685             
Leu Thr Trp Asp Tyr Gly Tyr Glu Ala Gly Thr Val Pro Glu Lys Glu 
    690                 695                 700                 
Ile Phe Cys Gln Cys Gly Val Asn Lys Cys Arg Lys Lys Ile Leu 
705                 710                 715                 

<210> 3
<211> 5636
<212> DNA
<213> Homo sapiens

<400> 3
gaatgtttca tccatttgtg gaccaaaaga tggagttggt ttttattttt aaaaagataa       60

tgttaatgat ctgataccac tacaaatatt tacgtgagaa gattcatgga cttgtctttt      120

ggttggactg tcactcattt ctgaaagttt cttcagccac aatttctatt tgaaaattca      180

agtatcaaag gataccaggt ttagaatggt ataatgatgt attttgtctg aggactgcaa      240

attttataga gaccacagtt ggattccagt gatattctgc aatcaaagtg atttgataaa      300

cctaattttg aagcatttta tatttataag cgacatcaaa agatgggaga aaaaaatggc      360

gatgcaaaaa ctttctggat ggagctagaa gatgatggaa aagtggactt catttttgaa      420

caagtacaaa atgtgctgca gtcactgaaa caaaagatca aagatgggtc tgccaccaat      480

aaagaataca tccaagcaat gattctagtg aatgaagcaa ctataattaa cagttcaaca      540

tcaataaagg atcctatgcc tgtgactcag aaggaacagg aaaacaaatc caatgcattt      600

ccctctacat catgtgaaaa ctcctttcca gaagactgta catttctaac aacagaaaat      660

aaggaaattc tctctcttga agataaagtt gtagacttta gagaaaaaga ctcatcttcg      720

aatttatctt accaaagtca tgactgctct ggtgcttgtc tgatgaaaat gccactgaac      780

ttgaagggag aaaaccctct gcagctgcca atcaaatgtc acttccaaag acgacatgca      840

aagacaaact ctcattcttc agcactccac gtgagttata aaaccccttg tggaaggagt      900

ctacgaaacg tggaggaagt ttttcgttac ctgcttgaga cagagtgtaa ctttttattt      960

acagataact tttctttcaa tacctatgtt cagttggctc ggaattaccc aaagcaaaaa     1020

gaagttgttt ctgatgtgga tattagcaat ggagtggaat cagtgcccat ttctttctgt     1080

aatgaaattg acagtagaaa gctcccacag tttaagtaca gaaagactgt gtggcctcga     1140

gcatataatc taaccaactt ttccagcatg tttactgatt cctgtgactg ctctgagggc     1200

tgcatagaca taacaaaatg tgcatgtctt caactgacag caaggaatgc caaaacttcc     1260

cccttgtcaa gtgacaaaat aaccactgga tataaatata aaagactaca gagacagatt     1320

cctactggca tttatgaatg cagccttttg tgcaaatgta atcgacaatt gtgtcaaaac     1380

cgagttgtcc aacatggtcc tcaagtgagg ttacaggtgt tcaaaactga gcagaaggga     1440

tggggtgtac gctgtctaga tgacattgac agagggacat ttgtttgcat ttattcagga     1500

agattactaa gcagagctaa cactgaaaaa tcttatggta ttgatgaaaa cgggagagat     1560

gagaatacta tgaaaaatat attttcaaaa aagaggaaat tagaagttgc atgttcagat     1620

tgtgaagttg aagttctccc attaggattg gaaacacatc ctagaactgc taaaactgag     1680

aaatgtccac caaagttcag taataatccc aaggagctta ctgtggaaac gaaatatgat     1740

aatatttcaa gaattcaata tcattcagtt attagagatc ctgaatccaa gacagccatt     1800

tttcaacaca atgggaaaaa aatggaattt gtttcctcgg agtctgtcac tccagaagat     1860

aatgatggat ttaaaccacc ccgagagcat ctgaactcta aaaccaaggg agcacaaaag     1920

gactcaagtt caaaccatgt tgatgagttt gaagataatc tgctgattga atcagatgtg     1980

atagatataa ctaaatatag agaagaaact ccaccaagga gcagatgtaa ccaggcgacc     2040

acattggata atcagaatat taaaaaggca attgaggttc aaattcagaa accccaagag     2100

ggacgatcta cagcatgtca aagacagcag gtattttgtg atgaagagtt gctaagtgaa     2160

accaagaata cttcatctga ttctctaaca aagttcaata aagggaatgt gtttttattg     2220

gatgccacaa aagaaggaaa tgtcggccgc ttccttaatc atagttgttg cccaaatctc     2280

ttggtacaga atgtttttgt agaaacacac aacaggaatt ttccattggt ggcattcttc     2340

accaacaggt atgtgaaagc aagaacagag ctaacatggg attatggcta tgaagctggg     2400

actgtgcctg agaaggaaat cttctgccaa tgtggggtta ataaatgtag aaaaaaaata     2460

ttataaatat gtaactaacg cctgtttgtg aaattagctt atcaggctga aattaaagcc     2520

atgcaaaaga aggtctaggt ccatcaagga aattcccctc cgttttcctt tgtcatgggg     2580

tttatgtttt atttcagatt ttatttgtgt gacttagaaa ttccaggaac acaattagga     2640

tattttcata cacatagggt atcttgttca ctgctgtgct actttacatg agtaggatgg     2700

aagtgtatat tttatatgaa ataccactgt acaatttata atttatttac aaattatata     2760

ttaagagaaa caaatgtcat aacagaactc agctgtttct aattgctttt gtgactgtta     2820

ccttttagtt catgcccccc caaagagcta aatttcacat ttttacctac aaaattgatt     2880

tttaattcct ggcaaataat ttaccattat gagctacaag gtgggcaaca gcgcctgagg     2940

atctaatttt atgcatatta ctcccaagta ttttaacact tgttggagaa gcaatatctg     3000

gatcgataaa acactgtccc atcaaccatt tgagtgggga gagggagaag ctcttctgta     3060

agtaagattc tggcaagctc tttgaaatga gtcttctttc ccacagattt tctctactct     3120

ttctatacaa acagatagga gaagagggaa tagaaacctg gaggaacttg aatatttttg     3180

ttctagatag agatacagtt actgaaaagg aaacctagaa agtagtcaca cgttgcttat     3240

ttaggccaga agtaattgta ctgggcaaaa atttcactta aaaaacacaa gaagtccagg     3300

tatggtggct cagacctgta atcccagcac tttgagaggc cgaggcaggt ggattacttg     3360

agcctagggg ttcaagacca gcttgggcaa catgtcaaaa ccctgtctct acaaaaaata     3420

caaaaattag cctggcatga tggcatgtgc ccgtagtctc agctactcag gagtgaggtg     3480

ggaggatcat ttgagctcag aaggtcaagg ctgcaatgag acataatttc accatagtac     3540

ttccagcctg ggcaatagag caagactctc tctcaaaaaa aacagcacac acacacacac     3600

acgaaaacaa ttctgaacta tgaaatctga aacagcccct tggtatctcc tgggcatgat     3660

ttgcaaatct ttttttttta cagaaaaaag gcaaagagta agcactttgc cataggttac     3720

ttggccgtga tcatctatct agtggaaaag gggactggga agcccaagca gactgggaaa     3780

ccagacagct aggaaaagga gcaaaacata gcccagcaac ctacagatga agaaagttga     3840

gaaatccatt tattcaccat agagacgcag gaatttcagg caatgcacta aaatgaaatg     3900

ggggaaaaaa gcttgatcag tatgggaacc atttttgtgc aaaagggaat attatggatc     3960

agccagtatt tctttgagct ctgcctgtgg agtccatttg acctttagaa atatgaggta     4020

ttctgtcagt tttatcttct tggagaaatt tctcctaaaa tcttgatttg ctttagtctg     4080

gactggttca tagccatcat cttccatcag taccccagag attcactttg tctcttatgt     4140

gggatctgtt tccagttaga tgccattatt ttccttttcc ttggtttact cttccacata     4200

ttggtaaagc tcttccaata gcttttggaa aggaaaaatg aaaagtaaat gttttgaatc     4260

tctgtgtgtt tgacaatgtc tttattttac ccttatacct gattgctgtt ttggttggca     4320

aggtatagga ttctttagtg gtctccatgc ccagttttga agacatctgc tagctttcag     4380

tgctgttgct gtggagtctg aaaatctgtc ttctggcttc cagggtgact actggaaatt     4440

gaatgccatt ctgttccttc tcttttgcat atataatcca tttttatctc tcttgaagct     4500

tataggttta tctttgtctc aatgttctgt ccctgttaag agtccatttt catcctttgt     4560

actaggtgcc tggtgggatc attccgtctg aaactaatga tttcccatct cttcactgtt     4620

tctggaattc ctgttttcca gatgttagac ctccagaatt tgatctctaa ttttcctatc     4680

ttttctctta actttcagct ctgtcttctt gctaggacct tttcctagga gcatttctca     4740

atttaatctt ccagttcatc tgttgcattt tatttttcta gtctcatatt gtctcatatt     4800

tttaatttct aagagctccc cttctccgaa tattcttttt ttttaatagc atcctatttt     4860

ggctcatggt tgcagtattt tatctccttg aagatgtttg tgtgtttatg tatgtatatg     4920

cacacacgta tacatacaca tacaggcatg catctctgta ttctttcggc ataatctgtg     4980

tcctccaggg tttgtttctt tgtttcccct gtatgtttgt tttggtcgtt cacattatag     5040

gctttcctca gagttaatgg tcttggtagt ctactcatat ttaagtgtgg aacaccaaaa     5100

agcttactat aagctgagag tgtggtaaag ggctctttgt tttactatga cctacctgag     5160

ctatcttgct ggggaacacc ctaatgtcag tctctttata aagggccttt cattttggcc     5220

tggcaagaaa tactctttca tcctcctgca tggagggcaa aaaaaaattt aaaaattggc     5280

tgctagggtc tgtctgctca cttccctgtt ttgcagaccc cacactcttc tgcaattcat     5340

ttcatagttg tcaagactat acaaattgtc ctttttaatg ttctctcttc tgctatccct     5400

agttggcagt cttcctcttt acaacctgct gaaagtggaa gacctccagt tttcctttaa     5460

ttcctcagca aaccaccaac tattatatgt cttttttcca gaacaactta ttttttaact     5520

ataattatat gcatttatgt tagattcact gaaaacctca tcttgtatgg tgctctgtac     5580

cctatgggtg ctaaataaag gcttgctact ggcaactgga aaaaaaaaaa aaaaaa         5636


<210> 4
<211> 707
<212> PRT
<213> Homo sapiens

<400> 4
Met Gly Glu Lys Asn Gly Asp Ala Lys Thr Phe Trp Met Glu Leu Glu 
1               5                   10                  15      
Asp Asp Gly Lys Val Asp Phe Ile Phe Glu Gln Val Gln Asn Val Leu 
            20                  25                  30          
Gln Ser Leu Lys Gln Lys Ile Lys Asp Gly Ser Ala Thr Asn Lys Glu 
        35                  40                  45              
Tyr Ile Gln Ala Met Ile Leu Val Asn Glu Ala Thr Ile Ile Asn Ser 
    50                  55                  60                  
Ser Thr Ser Ile Lys Asp Pro Met Pro Val Thr Gln Lys Glu Gln Glu 
65                  70                  75                  80  
Asn Lys Ser Asn Ala Phe Pro Ser Thr Ser Cys Glu Asn Ser Phe Pro 
                85                  90                  95      
Glu Asp Cys Thr Phe Leu Thr Thr Glu Asn Lys Glu Ile Leu Ser Leu 
            100                 105                 110         
Glu Asp Lys Val Val Asp Phe Arg Glu Lys Asp Ser Ser Ser Asn Leu 
        115                 120                 125             
Ser Tyr Gln Ser His Asp Cys Ser Gly Ala Cys Leu Met Lys Met Pro 
    130                 135                 140                 
Leu Asn Leu Lys Gly Glu Asn Pro Leu Gln Leu Pro Ile Lys Cys His 
145                 150                 155                 160 
Phe Gln Arg Arg His Ala Lys Thr Asn Ser His Ser Ser Ala Leu His 
                165                 170                 175     
Val Ser Tyr Lys Thr Pro Cys Gly Arg Ser Leu Arg Asn Val Glu Glu 
            180                 185                 190         
Val Phe Arg Tyr Leu Leu Glu Thr Glu Cys Asn Phe Leu Phe Thr Asp 
        195                 200                 205             
Asn Phe Ser Phe Asn Thr Tyr Val Gln Leu Ala Arg Asn Tyr Pro Lys 
    210                 215                 220                 
Gln Lys Glu Val Val Ser Asp Val Asp Ile Ser Asn Gly Val Glu Ser 
225                 230                 235                 240 
Val Pro Ile Ser Phe Cys Asn Glu Ile Asp Ser Arg Lys Leu Pro Gln 
                245                 250                 255     
Phe Lys Tyr Arg Lys Thr Val Trp Pro Arg Ala Tyr Asn Leu Thr Asn 
            260                 265                 270         
Phe Ser Ser Met Phe Thr Asp Ser Cys Asp Cys Ser Glu Gly Cys Ile 
        275                 280                 285             
Asp Ile Thr Lys Cys Ala Cys Leu Gln Leu Thr Ala Arg Asn Ala Lys 
    290                 295                 300                 
Thr Ser Pro Leu Ser Ser Asp Lys Ile Thr Thr Gly Tyr Lys Tyr Lys 
305                 310                 315                 320 
Arg Leu Gln Arg Gln Ile Pro Thr Gly Ile Tyr Glu Cys Ser Leu Leu 
                325                 330                 335     
Cys Lys Cys Asn Arg Gln Leu Cys Gln Asn Arg Val Val Gln His Gly 
            340                 345                 350         
Pro Gln Val Arg Leu Gln Val Phe Lys Thr Glu Gln Lys Gly Trp Gly 
        355                 360                 365             
Val Arg Cys Leu Asp Asp Ile Asp Arg Gly Thr Phe Val Cys Ile Tyr 
    370                 375                 380                 
Ser Gly Arg Leu Leu Ser Arg Ala Asn Thr Glu Lys Ser Tyr Gly Ile 
385                 390                 395                 400 
Asp Glu Asn Gly Arg Asp Glu Asn Thr Met Lys Asn Ile Phe Ser Lys 
                405                 410                 415     
Lys Arg Lys Leu Glu Val Ala Cys Ser Asp Cys Glu Val Glu Val Leu 
            420                 425                 430         
Pro Leu Gly Leu Glu Thr His Pro Arg Thr Ala Lys Thr Glu Lys Cys 
        435                 440                 445             
Pro Pro Lys Phe Ser Asn Asn Pro Lys Glu Leu Thr Val Glu Thr Lys 
    450                 455                 460                 
Tyr Asp Asn Ile Ser Arg Ile Gln Tyr His Ser Val Ile Arg Asp Pro 
465                 470                 475                 480 
Glu Ser Lys Thr Ala Ile Phe Gln His Asn Gly Lys Lys Met Glu Phe 
                485                 490                 495     
Val Ser Ser Glu Ser Val Thr Pro Glu Asp Asn Asp Gly Phe Lys Pro 
            500                 505                 510         
Pro Arg Glu His Leu Asn Ser Lys Thr Lys Gly Ala Gln Lys Asp Ser 
        515                 520                 525             
Ser Ser Asn His Val Asp Glu Phe Glu Asp Asn Leu Leu Ile Glu Ser 
    530                 535                 540                 
Asp Val Ile Asp Ile Thr Lys Tyr Arg Glu Glu Thr Pro Pro Arg Ser 
545                 550                 555                 560 
Arg Cys Asn Gln Ala Thr Thr Leu Asp Asn Gln Asn Ile Lys Lys Ala 
                565                 570                 575     
Ile Glu Val Gln Ile Gln Lys Pro Gln Glu Gly Arg Ser Thr Ala Cys 
            580                 585                 590         
Gln Arg Gln Gln Val Phe Cys Asp Glu Glu Leu Leu Ser Glu Thr Lys 
        595                 600                 605             
Asn Thr Ser Ser Asp Ser Leu Thr Lys Phe Asn Lys Gly Asn Val Phe 
    610                 615                 620                 
Leu Leu Asp Ala Thr Lys Glu Gly Asn Val Gly Arg Phe Leu Asn His 
625                 630                 635                 640 
Ser Cys Cys Pro Asn Leu Leu Val Gln Asn Val Phe Val Glu Thr His 
                645                 650                 655     
Asn Arg Asn Phe Pro Leu Val Ala Phe Phe Thr Asn Arg Tyr Val Lys 
            660                 665                 670         
Ala Arg Thr Glu Leu Thr Trp Asp Tyr Gly Tyr Glu Ala Gly Thr Val 
        675                 680                 685             
Pro Glu Lys Glu Ile Phe Cys Gln Cys Gly Val Asn Lys Cys Arg Lys 
    690                 695                 700                 
Lys Ile Leu 
705         

<210> 5
<211> 3034
<212> DNA
<213> Mus musculus

<400> 5
gcggggccgc ggaaactgtg tggagctccc ttggggctga tgtctccccc gctgaggtga      60

agccgcctcg ggactgcaga ctctggtgcg gacagtgcaa ggcgcgcggg gtgccaggcc     120

gcctcaaccc gctgtctcag tagcgggggt ggccggggct ctcagtcgcg tttcccccac     180

cgtcttgcgg cgctcacttt cgtggctggt gatttctgag taatttggct atcatgggct     240

gtagacagcg gagcacagac aagatcttca ggacactggt ccattccaca gagtgtttca     300

tgcatttgtg gaccaaaaca tgggatgaac tttaatttta aaaagacatt gtcagtagtc     360

ctgatccggc tttcaacctg gccttgaaga agatgctgtg cctgtttttc ttggactagt     420

agtcattctg aaagtctatt caagcacagt ttctatttgc aaattcaaat actaaagact     480

attaggaagt ggcctaacga gatactctct ttggggacta cagatttcat agagactgca     540

gttggagccc atttagtttt gattaacttc attttgaaga attttatata agcaacacca     600

aaagatggaa gaaaaaaatg gtgatgcaaa gactttctgg atggagctac aagatgatgg     660

taaagttgac ttaatgtttg agaaaacaca aaatgtccta cattcactga aacagaagat     720

aaaggatggg tctgccacaa atggagacta tgtccaagca atgaatctag taaatgaagc     780

cactctgagt aacacgcaaa cactggaaaa gggtatgttc attacttatt ccaatcctga     840

agtgaatact catcgtagca atcatacacc tgtgactcag agtgaacagg aaaacaaatc     900

aagtgcggtt ccctctgcat catgtgacaa ctcctgtcct aagggctgta ctatcccatc     960

tccaggaaaa aaagtattcc tccctgtgaa gaataaagct gacaatttag tgaaaaagga    1020

agccccactg catatatctt tccatcgcca tatctgctcc aggacttgtc taatggaaac    1080

cccactgtcc ttgaagggag aaaaccccct gcagctacca atcagatgtc acttccaaag    1140

acgacatgca aagacaaact ctcattcttc tgccctccat gtgaattata aaacgccctg    1200

tggacggaat ctacgaaaca tggaggaagt tttccattac ctgcttgaaa cagagtgtaa    1260

ctttttattc acagacaact tctctttcaa tacttatgtc cagttgactc ggaatcaccc    1320

aaagcaaaat gaagttgttt ctgacgtgga tattagtaat ggagtggaat cagtgtcgat    1380

tcctttctgt aatgaaattg acaacagtaa acttccacgg tttaagtata gaaatacagt    1440

atggccccga atatatcatc tgaacttttc caacatgttt tctgattcat gtgactgttc    1500

tgagggctgc atagacataa aaaaatgtgc atgtcttcag ttgacagcaa agaatgccaa    1560

ggcatgtccc ttgtcatcgg atggagaatg tgctggatat aaatacaaaa gactgcagag    1620

gctcatacct actggcattt atgaatgcaa cctgctctgc aagtgtaaca aacagatgtg    1680

tcaaaaccga gttatccagc atggtgtccg ggtgaggcta caggtgttca aaagtgagaa    1740

gaagggctgg ggagtacgct gcctggatga cattgacaaa gggacatttg tgtgcattta    1800

ttcaggaagg ttactgcgca gagccactcc tgagaaaact aatataggtg aaaatggaag    1860

agagcaacag cacattgtga aaaattcatt ttccaaaaag aggaaactag aagttgtgtg    1920

ttcagattgt gacgcacact gtgacagtcc taaggctgag gactgccctc ccaagcttag    1980

tggtgatctc aaagagcccg ctgtggaaat gaaccataga aatatttcaa gaactcagca    2040

tcattcagtc attagaagaa ctaaatccaa gacaactgtt tttcattaca gtgagaaaaa    2100

catgggattt gtttgctcag attctgccgc cccagaagat aagaatggat ttaaaccagc    2160

tcaagaacac gtgaactctg aagctaggag agctcacgag gacttaagtt caaacccagc    2220

tggagattct gaagacacac agctgactga atcagacgtg atagatataa ctgcaagtag    2280

agaagactct gccccagcat acaggtgtaa gcacgcaacc atagtggatc gtaaggacac    2340

taaacaggtg cttgaagtcc caggaaagaa gtcccaagag gaagagcctg cagcctctca    2400

aagccagcag gccttgtgtg atgaggagct gccaagtgag aggacaaaga ttccatctgc    2460

ttccctgatg cagctcagta aggagagtct gtttctattg gatgcttcaa aagaaggaaa    2520

tgtgggccgt ttcctcaatc atagttgctg tccaaatctc tgggtgcaga atgtttttgt    2580

agaaacacat gacaggaatt tcccattggt ggccttcttc accaacaggt atgtgaaagc    2640

aaggacagaa ctaacgtggg attatggtta tgaagctggg gccacgcctg caaaggaaat    2700

cctctgccaa tgtgggttta ataagtgtcg gaaaaaatta atataacttt atatctgata    2760

tccatccgtg aactgagctg ctcaatgtat aacaatatca gttgtcaaag agattatggt    2820

taatacttct gtttcctttg ttcagggtat tgatgtttta tgtctaattt tgtatcttag    2880

gttagaagca aaataagggc actcatcaag tatcacagtg ttattacagt taattaactt    2940

tacatgagta gaatataaat aatatatttt atgtacatat cattgtataa tttgtaactt    3000

ttgtatttta tatattaata taaaattata ctag                                3034


<210> 6
<211> 713
<212> PRT
<213> Mus musculus

<400> 6
Met Glu Glu Lys Asn Gly Asp Ala Lys Thr Phe Trp Met Glu Leu Gln 
1               5                   10                  15      
Asp Asp Gly Lys Val Asp Leu Met Phe Glu Lys Thr Gln Asn Val Leu 
            20                  25                  30          
His Ser Leu Lys Gln Lys Ile Lys Asp Gly Ser Ala Thr Asn Gly Asp 
        35                  40                  45              
Tyr Val Gln Ala Met Asn Leu Val Asn Glu Ala Thr Leu Ser Asn Thr 
    50                  55                  60                  
Gln Thr Leu Glu Lys Gly Met Phe Ile Thr Tyr Ser Asn Pro Glu Val 
65                  70                  75                  80  
Asn Thr His Arg Ser Asn His Thr Pro Val Thr Gln Ser Glu Gln Glu 
                85                  90                  95      
Asn Lys Ser Ser Ala Val Pro Ser Ala Ser Cys Asp Asn Ser Cys Pro 
            100                 105                 110         
Lys Gly Cys Thr Ile Pro Ser Pro Gly Lys Lys Val Phe Leu Pro Val 
        115                 120                 125             
Lys Asn Lys Ala Asp Asn Leu Val Lys Lys Glu Ala Pro Leu His Ile 
    130                 135                 140                 
Ser Phe His Arg His Ile Cys Ser Arg Thr Cys Leu Met Glu Thr Pro 
145                 150                 155                 160 
Leu Ser Leu Lys Gly Glu Asn Pro Leu Gln Leu Pro Ile Arg Cys His 
                165                 170                 175     
Phe Gln Arg Arg His Ala Lys Thr Asn Ser His Ser Ser Ala Leu His 
            180                 185                 190         
Val Asn Tyr Lys Thr Pro Cys Gly Arg Asn Leu Arg Asn Met Glu Glu 
        195                 200                 205             
Val Phe His Tyr Leu Leu Glu Thr Glu Cys Asn Phe Leu Phe Thr Asp 
    210                 215                 220                 
Asn Phe Ser Phe Asn Thr Tyr Val Gln Leu Thr Arg Asn His Pro Lys 
225                 230                 235                 240 
Gln Asn Glu Val Val Ser Asp Val Asp Ile Ser Asn Gly Val Glu Ser 
                245                 250                 255     
Val Ser Ile Pro Phe Cys Asn Glu Ile Asp Asn Ser Lys Leu Pro Arg 
            260                 265                 270         
Phe Lys Tyr Arg Asn Thr Val Trp Pro Arg Ile Tyr His Leu Asn Phe 
        275                 280                 285             
Ser Asn Met Phe Ser Asp Ser Cys Asp Cys Ser Glu Gly Cys Ile Asp 
    290                 295                 300                 
Ile Lys Lys Cys Ala Cys Leu Gln Leu Thr Ala Lys Asn Ala Lys Ala 
305                 310                 315                 320 
Cys Pro Leu Ser Ser Asp Gly Glu Cys Ala Gly Tyr Lys Tyr Lys Arg 
                325                 330                 335     
Leu Gln Arg Leu Ile Pro Thr Gly Ile Tyr Glu Cys Asn Leu Leu Cys 
            340                 345                 350         
Lys Cys Asn Lys Gln Met Cys Gln Asn Arg Val Ile Gln His Gly Val 
        355                 360                 365             
Arg Val Arg Leu Gln Val Phe Lys Ser Glu Lys Lys Gly Trp Gly Val 
    370                 375                 380                 
Arg Cys Leu Asp Asp Ile Asp Lys Gly Thr Phe Val Cys Ile Tyr Ser 
385                 390                 395                 400 
Gly Arg Leu Leu Arg Arg Ala Thr Pro Glu Lys Thr Asn Ile Gly Glu 
                405                 410                 415     
Asn Gly Arg Glu Gln Gln His Ile Val Lys Asn Ser Phe Ser Lys Lys 
            420                 425                 430         
Arg Lys Leu Glu Val Val Cys Ser Asp Cys Asp Ala His Cys Asp Ser 
        435                 440                 445             
Pro Lys Ala Glu Asp Cys Pro Pro Lys Leu Ser Gly Asp Leu Lys Glu 
    450                 455                 460                 
Pro Ala Val Glu Met Asn His Arg Asn Ile Ser Arg Thr Gln His His 
465                 470                 475                 480 
Ser Val Ile Arg Arg Thr Lys Ser Lys Thr Thr Val Phe His Tyr Ser 
                485                 490                 495     
Glu Lys Asn Met Gly Phe Val Cys Ser Asp Ser Ala Ala Pro Glu Asp 
            500                 505                 510         
Lys Asn Gly Phe Lys Pro Ala Gln Glu His Val Asn Ser Glu Ala Arg 
        515                 520                 525             
Arg Ala His Glu Asp Leu Ser Ser Asn Pro Ala Gly Asp Ser Glu Asp 
    530                 535                 540                 
Thr Gln Leu Thr Glu Ser Asp Val Ile Asp Ile Thr Ala Ser Arg Glu 
545                 550                 555                 560 
Asp Ser Ala Pro Ala Tyr Arg Cys Lys His Ala Thr Ile Val Asp Arg 
                565                 570                 575     
Lys Asp Thr Lys Gln Val Leu Glu Val Pro Gly Lys Lys Ser Gln Glu 
            580                 585                 590         
Glu Glu Pro Ala Ala Ser Gln Ser Gln Gln Ala Leu Cys Asp Glu Glu 
        595                 600                 605             
Leu Pro Ser Glu Arg Thr Lys Ile Pro Ser Ala Ser Leu Met Gln Leu 
    610                 615                 620                 
Ser Lys Glu Ser Leu Phe Leu Leu Asp Ala Ser Lys Glu Gly Asn Val 
625                 630                 635                 640 
Gly Arg Phe Leu Asn His Ser Cys Cys Pro Asn Leu Trp Val Gln Asn 
                645                 650                 655     
Val Phe Val Glu Thr His Asp Arg Asn Phe Pro Leu Val Ala Phe Phe 
            660                 665                 670         
Thr Asn Arg Tyr Val Lys Ala Arg Thr Glu Leu Thr Trp Asp Tyr Gly 
        675                 680                 685             
Tyr Glu Ala Gly Ala Thr Pro Ala Lys Glu Ile Leu Cys Gln Cys Gly 
    690                 695                 700                 
Phe Asn Lys Cys Arg Lys Lys Leu Ile 
705                 710             

<210> 7
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Nucleotide sequence of the target sequence of siRNA 1 targeting
      nucleotide sequence encoding Homo sapiens histone
      methyltransferase SET domain bifurcated 2 (Setdb2)

<400> 7
ccgagagcat ctgaactcta a                                              21


<210> 8
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Nucleotide sequence of the target sequence siRNA 2 targeting
      nucleotide sequence encoding Homo sapiens histone
      methyltransferase SET domain bifurcated 2 (Setdb2)

<400> 8
tcggccgctt ccttaatcat a                                              21


<210> 9
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 9
catggaatgg ctaaagacaa gacc                                           24


<210> 10
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 10
ccattaaggg cattttggac a                                              21


<210> 11
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 11
tttgtgttca cgctcaccgt gccca                                          25


<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 12
cctcttcaca tgcctccctg                                                20


<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 13
cggggatgga agcttgtctt                                                20


<210> 14
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 14
gttccagcac tccagactcc                                                20


<210> 15
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 15
agtggcgaga cctacctgt                                                 19


<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 16
cctctgggtg tggatgtcac                                                20


<210> 17
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 17
tgtccattca atccaggccc                                                20


<210> 18
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 18
aatgggccat attagtagaa gc                                             22


<210> 19
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer

<400> 19
gatcttgctc aaaggtcacc a                                              21


