                         SEQUENCE LISTING

<110>  Stichting Katholieke Universiteit
       Stichting VU-VUmc
 
<120>  A novel auto-active and intracellular mutant of MET

<130>  P6053483PCT

<150>  14194066.8
<151>  2014-11-20

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer HGF-Fw204

<400>  1
ctgcagcatg tcctcctgca                                                   20


<210>  2
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer HGF-Rv504

<400>  2
gaggtcaaat tcatggccaa                                                   20


<210>  3
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer p361-Fw

<400>  3
tgccagagaa gagtgtggtg                                                   20


<210>  4
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer p425-Rv

<400>  4
gttaagctgc cgtgcaacat c                                                 21


<210>  5
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer MET 1997-Fw

<400>  5
ctccttggaa atgagagctg                                                   20


<210>  6
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer MET2342Rv

<400>  6
cagttgaaat ggtttgggct g                                                 21


<210>  7
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer MET1997Fw

<400>  7
ctccttggaa atgagagctg                                                   20


<210>  8
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer MET2414Rev

<400>  8
gggatcttca cggtaactg                                                    19


<210>  9
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer MET173EcoR1-Fw

<400>  9
cgaattcgat aaacctctca taatgaagg                                         29


<210>  10
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer MET4421NotI-Rv

<400>  10
agcggccgcc tatgatgtct cccagaagg                                         29


<210>  11
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer MET173Fw

<400>  11
gataaacctc tcataatgaa ggc                                               23


<210>  12
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer MET3028NheI-Rv

<400>  12
cgctagcctg atctggttga actattac                                          28


<210>  13
<211>  1390
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe 
1               5                   10                  15      


Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys 
            20                  25                  30          


Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala 
        35                  40                  45              


Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu 
    50                  55                  60                  


Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys 
65                  70                  75                  80  


Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe 
                85                  90                  95      


Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp 
            100                 105                 110         


Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp 
        115                 120                 125             


Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 
    130                 135                 140                 


Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys 
145                 150                 155                 160 


Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val 
                165                 170                 175     


Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe 
            180                 185                 190         


Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp 
        195                 200                 205             


His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp 
    210                 215                 220                 


Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu 
225                 230                 235                 240 


Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn 
                245                 250                 255     


Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln 
            260                 265                 270         


Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu 
        275                 280                 285             


His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg 
    290                 295                 300                 


Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala 
305                 310                 315                 320 


Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser 
                325                 330                 335     


Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp 
            340                 345                 350         


Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys 
        355                 360                 365             


Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg 
    370                 375                 380                 


Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg 
385                 390                 395                 400 


Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr 
                405                 410                 415     


Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly 
            420                 425                 430         


Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly 
        435                 440                 445             


Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln 
    450                 455                 460                 


Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu 
465                 470                 475                 480 


Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu 
                485                 490                 495     


Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys 
            500                 505                 510         


Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln 
        515                 520                 525             


Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys 
    530                 535                 540                 


Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile 
545                 550                 555                 560 


Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu 
                565                 570                 575     


Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg 
            580                 585                 590         


Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu 
        595                 600                 605             


Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys 
    610                 615                 620                 


Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile 
625                 630                 635                 640 


Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp 
                645                 650                 655     


Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly 
            660                 665                 670         


Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg 
        675                 680                 685             


His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn 
    690                 695                 700                 


Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe 
705                 710                 715                 720 


Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe 
                725                 730                 735     


Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser 
            740                 745                 750         


Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn Leu Asn 
        755                 760                 765             


Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala Gly Arg 
    770                 775                 780                 


Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile Ile Cys 
785                 790                 795                 800 


Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro Leu Lys 
                805                 810                 815     


Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr Phe Asp 
            820                 825                 830         


Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys Pro Val 
        835                 840                 845             


Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly Asn Asp 
    850                 855                 860                 


Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn Lys 
865                 870                 875                 880 


Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys Thr Val 
                885                 890                 895     


Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu Trp Lys 
            900                 905                 910         


Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln Pro Asp 
        915                 920                 925             


Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Ile Ser Thr Ala 
    930                 935                 940                 


Leu Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg Lys Gln 
945                 950                 955                 960 


Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg Val His 
                965                 970                 975     


Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser Pro Thr 
            980                 985                 990         


Thr Glu Met Val Ser Asn Glu Ser  Val Asp Tyr Arg Ala  Thr Phe Pro 
        995                 1000                 1005             


Glu Asp  Gln Phe Pro Asn Ser  Ser Gln Asn Gly Ser  Cys Arg Gln 
    1010                 1015                 1020             


Val Gln  Tyr Pro Leu Thr Asp  Met Ser Pro Ile Leu  Thr Ser Gly 
    1025                 1030                 1035             


Asp Ser  Asp Ile Ser Ser Pro  Leu Leu Gln Asn Thr  Val His Ile 
    1040                 1045                 1050             


Asp Leu  Ser Ala Leu Asn Pro  Glu Leu Val Gln Ala  Val Gln His 
    1055                 1060                 1065             


Val Val  Ile Gly Pro Ser Ser  Leu Ile Val His Phe  Asn Glu Val 
    1070                 1075                 1080             


Ile Gly  Arg Gly His Phe Gly  Cys Val Tyr His Gly  Thr Leu Leu 
    1085                 1090                 1095             


Asp Asn  Asp Gly Lys Lys Ile  His Cys Ala Val Lys  Ser Leu Asn 
    1100                 1105                 1110             


Arg Ile  Thr Asp Ile Gly Glu  Val Ser Gln Phe Leu  Thr Glu Gly 
    1115                 1120                 1125             


Ile Ile  Met Lys Asp Phe Ser  His Pro Asn Val Leu  Ser Leu Leu 
    1130                 1135                 1140             


Gly Ile  Cys Leu Arg Ser Glu  Gly Ser Pro Leu Val  Val Leu Pro 
    1145                 1150                 1155             


Tyr Met  Lys His Gly Asp Leu  Arg Asn Phe Ile Arg  Asn Glu Thr 
    1160                 1165                 1170             


His Asn  Pro Thr Val Lys Asp  Leu Ile Gly Phe Gly  Leu Gln Val 
    1175                 1180                 1185             


Ala Lys  Gly Met Lys Tyr Leu  Ala Ser Lys Lys Phe  Val His Arg 
    1190                 1195                 1200             


Asp Leu  Ala Ala Arg Asn Cys  Met Leu Asp Glu Lys  Phe Thr Val 
    1205                 1210                 1215             


Lys Val  Ala Asp Phe Gly Leu  Ala Arg Asp Met Tyr  Asp Lys Glu 
    1220                 1225                 1230             


Tyr Tyr  Ser Val His Asn Lys  Thr Gly Ala Lys Leu  Pro Val Lys 
    1235                 1240                 1245             


Trp Met  Ala Leu Glu Ser Leu  Gln Thr Gln Lys Phe  Thr Thr Lys 
    1250                 1255                 1260             


Ser Asp  Val Trp Ser Phe Gly  Val Leu Leu Trp Glu  Leu Met Thr 
    1265                 1270                 1275             


Arg Gly  Ala Pro Pro Tyr Pro  Asp Val Asn Thr Phe  Asp Ile Thr 
    1280                 1285                 1290             


Val Tyr  Leu Leu Gln Gly Arg  Arg Leu Leu Gln Pro  Glu Tyr Cys 
    1295                 1300                 1305             


Pro Asp  Pro Leu Tyr Glu Val  Met Leu Lys Cys Trp  His Pro Lys 
    1310                 1315                 1320             


Ala Glu  Met Arg Pro Ser Phe  Ser Glu Leu Val Ser  Arg Ile Ser 
    1325                 1330                 1335             


Ala Ile  Phe Ser Thr Phe Ile  Gly Glu His Tyr Val  His Val Asn 
    1340                 1345                 1350             


Ala Thr  Tyr Val Asn Val Lys  Cys Val Ala Pro Tyr  Pro Ser Leu 
    1355                 1360                 1365             


Leu Ser  Ser Glu Asp Asn Ala  Asp Asp Glu Val Asp  Thr Arg Pro 
    1370                 1375                 1380             


Ala Ser  Phe Trp Glu Thr Ser  
    1385                 1390 


<210>  14
<211>  1310
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe 
1               5                   10                  15      


Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys 
            20                  25                  30          


Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala 
        35                  40                  45              


Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu 
    50                  55                  60                  


Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys 
65                  70                  75                  80  


Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe 
                85                  90                  95      


Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp 
            100                 105                 110         


Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp 
        115                 120                 125             


Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 
    130                 135                 140                 


Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys 
145                 150                 155                 160 


Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val 
                165                 170                 175     


Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe 
            180                 185                 190         


Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp 
        195                 200                 205             


His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp 
    210                 215                 220                 


Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu 
225                 230                 235                 240 


Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn 
                245                 250                 255     


Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln 
            260                 265                 270         


Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu 
        275                 280                 285             


His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg 
    290                 295                 300                 


Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala 
305                 310                 315                 320 


Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser 
                325                 330                 335     


Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp 
            340                 345                 350         


Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys 
        355                 360                 365             


Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg 
    370                 375                 380                 


Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg 
385                 390                 395                 400 


Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr 
                405                 410                 415     


Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly 
            420                 425                 430         


Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly 
        435                 440                 445             


Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln 
    450                 455                 460                 


Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu 
465                 470                 475                 480 


Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu 
                485                 490                 495     


Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys 
            500                 505                 510         


Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln 
        515                 520                 525             


Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys 
    530                 535                 540                 


Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile 
545                 550                 555                 560 


Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu 
                565                 570                 575     


Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg 
            580                 585                 590         


Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu 
        595                 600                 605             


Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Val Ser Asn 
    610                 615                 620                 


Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe 
625                 630                 635                 640 


Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe 
                645                 650                 655     


Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser 
            660                 665                 670         


Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn Leu Asn 
        675                 680                 685             


Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala Gly Arg 
    690                 695                 700                 


Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile Ile Cys 
705                 710                 715                 720 


Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro Leu Lys 
                725                 730                 735     


Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr Phe Asp 
            740                 745                 750         


Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys Pro Val 
        755                 760                 765             


Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly Asn Asp 
    770                 775                 780                 


Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn Lys 
785                 790                 795                 800 


Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys Thr Val 
                805                 810                 815     


Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu Trp Lys 
            820                 825                 830         


Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln Pro Asp 
        835                 840                 845             


Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Ile Ser Thr Ala 
    850                 855                 860                 


Leu Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg Lys Gln 
865                 870                 875                 880 


Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg Val His 
                885                 890                 895     


Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser Pro Thr 
            900                 905                 910         


Thr Glu Met Val Ser Asn Glu Ser Val Asp Tyr Arg Ala Thr Phe Pro 
        915                 920                 925             


Glu Asp Gln Phe Pro Asn Ser Ser Gln Asn Gly Ser Cys Arg Gln Val 
    930                 935                 940                 


Gln Tyr Pro Leu Thr Asp Met Ser Pro Ile Leu Thr Ser Gly Asp Ser 
945                 950                 955                 960 


Asp Ile Ser Ser Pro Leu Leu Gln Asn Thr Val His Ile Asp Leu Ser 
                965                 970                 975     


Ala Leu Asn Pro Glu Leu Val Gln Ala Val Gln His Val Val Ile Gly 
            980                 985                 990         


Pro Ser Ser Leu Ile Val His Phe  Asn Glu Val Ile Gly  Arg Gly His 
        995                 1000                 1005             


Phe Gly  Cys Val Tyr His Gly  Thr Leu Leu Asp Asn  Asp Gly Lys 
    1010                 1015                 1020             


Lys Ile  His Cys Ala Val Lys  Ser Leu Asn Arg Ile  Thr Asp Ile 
    1025                 1030                 1035             


Gly Glu  Val Ser Gln Phe Leu  Thr Glu Gly Ile Ile  Met Lys Asp 
    1040                 1045                 1050             


Phe Ser  His Pro Asn Val Leu  Ser Leu Leu Gly Ile  Cys Leu Arg 
    1055                 1060                 1065             


Ser Glu  Gly Ser Pro Leu Val  Val Leu Pro Tyr Met  Lys His Gly 
    1070                 1075                 1080             


Asp Leu  Arg Asn Phe Ile Arg  Asn Glu Thr His Asn  Pro Thr Val 
    1085                 1090                 1095             


Lys Asp  Leu Ile Gly Phe Gly  Leu Gln Val Ala Lys  Gly Met Lys 
    1100                 1105                 1110             


Tyr Leu  Ala Ser Lys Lys Phe  Val His Arg Asp Leu  Ala Ala Arg 
    1115                 1120                 1125             


Asn Cys  Met Leu Asp Glu Lys  Phe Thr Val Lys Val  Ala Asp Phe 
    1130                 1135                 1140             


Gly Leu  Ala Arg Asp Met Tyr  Asp Lys Glu Tyr Tyr  Ser Val His 
    1145                 1150                 1155             


Asn Lys  Thr Gly Ala Lys Leu  Pro Val Lys Trp Met  Ala Leu Glu 
    1160                 1165                 1170             


Ser Leu  Gln Thr Gln Lys Phe  Thr Thr Lys Ser Asp  Val Trp Ser 
    1175                 1180                 1185             


Phe Gly  Val Leu Leu Trp Glu  Leu Met Thr Arg Gly  Ala Pro Pro 
    1190                 1195                 1200             


Tyr Pro  Asp Val Asn Thr Phe  Asp Ile Thr Val Tyr  Leu Leu Gln 
    1205                 1210                 1215             


Gly Arg  Arg Leu Leu Gln Pro  Glu Tyr Cys Pro Asp  Pro Leu Tyr 
    1220                 1225                 1230             


Glu Val  Met Leu Lys Cys Trp  His Pro Lys Ala Glu  Met Arg Pro 
    1235                 1240                 1245             


Ser Phe  Ser Glu Leu Val Ser  Arg Ile Ser Ala Ile  Phe Ser Thr 
    1250                 1255                 1260             


Phe Ile  Gly Glu His Tyr Val  His Val Asn Ala Thr  Tyr Val Asn 
    1265                 1270                 1275             


Val Lys  Cys Val Ala Pro Tyr  Pro Ser Leu Leu Ser  Ser Glu Asp 
    1280                 1285                 1290             


Asn Ala  Asp Asp Glu Val Asp  Thr Arg Pro Ala Ser  Phe Trp Glu 
    1295                 1300                 1305             


Thr Ser  
    1310 


<210>  15
<211>  1153
<212>  DNA
<213>  Homo sapiens

<400>  15
gttttcccaa atagtgcacc ccttgaagga gggacaaggc tgaccatatg tggctgggac       60

tttggatttc ggaggaataa taaatttgat ttaaagaaaa ctagagttct ccttggaaat      120

gagagctgca ccttgacttt aagtgagagc acgatgaata cgtaaggatc ttaaaatgct      180

ttstggggtg tgcttggaaa ataggttttg tttttgaatg aatatttctt ttaaaattgc      240

tcaattacct aaacagtggg aattctagac acatttcaat tggtggaaaa acatgtactt      300

taaaaaggtg ttgtaaattt attttttgtt gcatctgtca atttgaatta atatctgtac      360

cttaaaaatt aagcagattg ttttgtgtgt gtgtgtggag aagaaaaatc aagatgttta      420

tttgtttact ctcctactga caaaacttcc tccttccaaa attcatctac tccttttgct      480

gatttttctt cctttctctt gttttttagc aatcctactt ttcagttttg tcttcccatc      540

caccctcttt attgttatag cttaggatct tagctatact atgagctgtg agagtctggt      600

cattgataat aatttaaaat aaacattttc atcaagattt gtaattagac taagtcactc      660

tggggaagga agaaatgggg aaaattgggt ctggaagaca gttatgtttc tgcttcttag      720

agttggaaga gctcagttta atcaagtacc aaaagtactt taaaggtttt tttttcaaat      780

ctcaaatgtt ttccagtcaa ggatagcttg tccacaacaa aggtaagttt gagatccagt      840

cagattaaac agcctacact agaaaaggct tccactcagg aaattcccac ttaggaacca      900

ttgagttata tccttttgat ttgtggatat aattctaaaa tatgtgtatc tctaatagct      960

aaaattcact tccttaattt tttttgttca gtgtgtcaaa cagtattctt gaatgttata     1020

ccccagccca aaccatttca actgagtttg ctgttaaatt gaaaattgac ttagccaacc     1080

gagagacaag catcttcagt taccgtgaag atcccattgt ctatgaaatt catccaacca     1140

aatcttttat tag                                                        1153


<210>  16
<211>  161
<212>  DNA
<213>  Homo sapiens

<400>  16
gttttcccaa atagtgcacc ccttgaagga gggacaaggc tgaccatatg tggctgggac       60

tttggatttc ggaggaataa taaatttgat ttaaagaaaa ctagagttct ccttggaaat      120

gagagctgca ccttgacttt aagtgagagc acgatgaata c                          161


<210>  17
<211>  83
<212>  DNA
<213>  Homo sapiens

<400>  17
gtaaggatct taaaatgctt tstggggtgt gcttggaaaa taggttttgt ttttgaatga       60

atatttcttt taaaattgct caa                                               83


<210>  18
<211>  63
<212>  DNA
<213>  Homo sapiens

<400>  18
ttacctaaac agtgggaatt ctagacacat ttcaattggt ggaaaaacat gtactttaaa       60

aag                                                                     63


<210>  19
<211>  684
<212>  DNA
<213>  Homo sapiens

<400>  19
gtgttgtaaa tttatttttt gttgcatctg tcaatttgaa ttaatatctg taccttaaaa       60

attaagcaga ttgttttgtg tgtgtgtgtg gagaagaaaa atcaagatgt ttatttgttt      120

actctcctac tgacaaaact tcctccttcc aaaattcatc tactcctttt gctgattttt      180

cttcctttct cttgtttttt agcaatccta cttttcagtt ttgtcttccc atccaccctc      240

tttattgtta tagcttagga tcttagctat actatgagct gtgagagtct ggtcattgat      300

aataatttaa aataaacatt ttcatcaaga tttgtaatta gactaagtca ctctggggaa      360

ggaagaaatg gggaaaattg ggtctggaag acagttatgt ttctgcttct tagagttgga      420

agagctcagt ttaatcaagt accaaaagta ctttaaaggt ttttttttca aatctcaaat      480

gttttccagt caaggatagc ttgtccacaa caaaggtaag tttgagatcc agtcagatta      540

aacagcctac actagaaaag gcttccactc aggaaattcc cacttaggaa ccattgagtt      600

atatcctttt gatttgtgga tataattcta aaatatgtgt atctctaata gctaaaattc      660

acttccttaa ttttttttgt tcag                                             684


<210>  20
<211>  162
<212>  DNA
<213>  Homo sapiens

<400>  20
tgtgtcaaac agtattcttg aatgttatac cccagcccaa accatttcaa ctgagtttgc       60

tgttaaattg aaaattgact tagccaaccg agagacaagc atcttcagtt accgtgaaga      120

tcccattgtc tatgaaattc atccaaccaa atcttttatt ag                         162


<210>  21
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  21
gagagcacga tgaatactgt gtc                                               23


<210>  22
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  22
gttgacatgc cactgtaaag ttc                                               23


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer

<400>  23
agatgcttgt ctctcggttg                                                   20


