б
<110>  ҽѧԺ
 
<120>  ư֢ҽҩ䷽ɸѡҩ

<160>  6     

<210>  1
<211>  648
<212>  PRT
<213>   (Homo sapiens)

<400>  1
Met Glu His Ile Gln Gly Ala Trp Lys Thr Ile Ser Asn Gly Phe Gly 
1               5                   10                  15      
Phe Lys Asp Ala Val Phe Asp Gly Ser Ser Cys Ile Ser Pro Thr Ile 
            20                  25                  30          
Val Gln Gln Phe Gly Tyr Gln Arg Arg Ala Ser Asp Asp Gly Lys Leu 
        35                  40                  45              
Thr Asp Pro Ser Lys Thr Ser Asn Thr Ile Arg Val Phe Leu Pro Asn 
    50                  55                  60                  
Lys Gln Arg Thr Val Val Asn Val Arg Asn Gly Met Ser Leu His Asp 
65                  70                  75                  80  
Cys Leu Met Lys Ala Leu Lys Val Arg Gly Leu Gln Pro Glu Cys Cys 
                85                  90                  95      
Ala Val Phe Arg Leu Leu His Glu His Lys Gly Lys Lys Ala Arg Leu 
            100                 105                 110         
Asp Trp Asn Thr Asp Ala Ala Ser Leu Ile Gly Glu Glu Leu Gln Val 
        115                 120                 125             
Asp Phe Leu Asp His Val Pro Leu Thr Thr His Asn Phe Ala Arg Lys 
    130                 135                 140                 
Thr Phe Leu Lys Leu Ala Phe Cys Asp Ile Cys Gln Lys Phe Leu Leu 
145                 150                 155                 160 
Asn Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Glu His Cys 
                165                 170                 175     
Ser Thr Lys Val Pro Thr Met Cys Val Asp Trp Ser Asn Ile Arg Gln 
            180                 185                 190         
Leu Leu Leu Phe Pro Asn Ser Thr Ile Gly Asp Ser Gly Val Pro Ala 
        195                 200                 205             
Leu Pro Ser Leu Thr Met Arg Arg Met Arg Glu Ser Val Ser Arg Met 
    210                 215                 220                 
Pro Val Ser Ser Gln His Arg Tyr Ser Thr Pro His Ala Phe Thr Phe 
225                 230                 235                 240 
Asn Thr Ser Ser Pro Ser Ser Glu Gly Ser Leu Ser Gln Arg Gln Arg 
                245                 250                 255     
Ser Thr Ser Thr Pro Asn Val His Met Val Ser Thr Thr Leu Pro Val 
            260                 265                 270         
Asp Ser Arg Met Ile Glu Asp Ala Ile Arg Ser His Ser Glu Ser Ala 
        275                 280                 285             
Ser Pro Ser Ala Leu Ser Ser Ser Pro Asn Asn Leu Ser Pro Thr Gly 
    290                 295                 300                 
Trp Ser Gln Pro Lys Thr Pro Val Pro Ala Gln Arg Glu Arg Ala Pro 
305                 310                 315                 320 
Val Ser Gly Thr Gln Glu Lys Asn Lys Ile Arg Pro Arg Gly Gln Arg 
                325                 330                 335     
Asp Ser Ser Tyr Tyr Trp Glu Ile Glu Ala Ser Glu Val Met Leu Ser 
            340                 345                 350         
Thr Arg Ile Gly Ser Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp 
        355                 360                 365             
His Gly Asp Val Ala Val Lys Ile Leu Lys Val Val Asp Pro Thr Pro 
    370                 375                 380                 
Glu Gln Phe Gln Ala Phe Arg Asn Glu Val Ala Val Leu Arg Lys Thr 
385                 390                 395                 400 
Arg His Val Asn Ile Leu Leu Phe Met Gly Tyr Met Thr Lys Asp Asn 
                405                 410                 415     
Leu Ala Ile Val Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr Lys His 
            420                 425                 430         
Leu His Val Gln Glu Thr Lys Phe Gln Met Phe Gln Leu Ile Asp Ile 
        435                 440                 445             
Ala Arg Gln Thr Ala Gln Gly Met Asp Tyr Leu His Ala Lys Asn Ile 
    450                 455                 460                 
Ile His Arg Asp Met Lys Ser Asn Asn Ile Phe Leu His Glu Gly Leu 
465                 470                 475                 480 
Thr Val Lys Ile Gly Asp Phe Gly Leu Ala Thr Val Lys Ser Arg Trp 
                485                 490                 495     
Ser Gly Ser Gln Gln Val Glu Gln Pro Thr Gly Ser Val Leu Trp Met 
            500                 505                 510         
Ala Pro Glu Val Ile Arg Met Gln Asp Asn Asn Pro Phe Ser Phe Gln 
        515                 520                 525             
Ser Asp Val Tyr Ser Tyr Gly Ile Val Leu Tyr Glu Leu Met Thr Gly 
    530                 535                 540                 
Glu Leu Pro Tyr Ser His Ile Asn Asn Arg Asp Gln Ile Ile Phe Met 
545                 550                 555                 560 
Val Gly Arg Gly Tyr Ala Ser Pro Asp Leu Ser Lys Leu Tyr Lys Asn 
                565                 570                 575     
Cys Pro Lys Ala Met Lys Arg Leu Val Ala Asp Cys Val Lys Lys Val 
            580                 585                 590         
Lys Glu Glu Arg Pro Leu Phe Pro Gln Ile Leu Ser Ser Ile Glu Leu 
        595                 600                 605             
Leu Gln His Ser Leu Pro Lys Ile Asn Arg Ser Ala Ser Glu Pro Ser 
    610                 615                 620                 
Leu His Arg Ala Ala His Thr Glu Asp Ile Asn Ala Cys Thr Leu Thr 
625                 630                 635                 640 
Thr Ser Pro Arg Leu Pro Val Phe 
                645             

<210>  2
<211>  1430
<212>  PRT
<213>   (Homo sapiens)

<400>  2
Met Thr Val Phe Arg Gln Glu Asn Val Asp Asp Tyr Tyr Asp Thr Gly 
1               5                   10                  15      
Glu Glu Leu Gly Ser Gly Gln Phe Ala Val Val Lys Lys Cys Arg Glu 
            20                  25                  30          
Lys Ser Thr Gly Leu Gln Tyr Ala Ala Lys Phe Ile Lys Lys Arg Arg 
        35                  40                  45              
Thr Lys Ser Ser Arg Arg Gly Val Ser Arg Glu Asp Ile Glu Arg Glu 
    50                  55                  60                  
Val Ser Ile Leu Lys Glu Ile Gln His Pro Asn Val Ile Thr Leu His 
65                  70                  75                  80  
Glu Val Tyr Glu Asn Lys Thr Asp Val Ile Leu Ile Leu Glu Leu Val 
                85                  90                  95      
Ala Gly Gly Glu Leu Phe Asp Phe Leu Ala Glu Lys Glu Ser Leu Thr 
            100                 105                 110         
Glu Glu Glu Ala Thr Glu Phe Leu Lys Gln Ile Leu Asn Gly Val Tyr 
        115                 120                 125             
Tyr Leu His Ser Leu Gln Ile Ala His Phe Asp Leu Lys Pro Glu Asn 
    130                 135                 140                 
Ile Met Leu Leu Asp Arg Asn Val Pro Lys Pro Arg Ile Lys Ile Ile 
145                 150                 155                 160 
Asp Phe Gly Leu Ala His Lys Ile Asp Phe Gly Asn Glu Phe Lys Asn 
                165                 170                 175     
Ile Phe Gly Thr Pro Glu Phe Val Ala Pro Glu Ile Val Asn Tyr Glu 
            180                 185                 190         
Pro Leu Gly Leu Glu Ala Asp Met Trp Ser Ile Gly Val Ile Thr Tyr 
        195                 200                 205             
Ile Leu Leu Ser Gly Ala Ser Pro Phe Leu Gly Asp Thr Lys Gln Glu 
    210                 215                 220                 
Thr Leu Ala Asn Val Ser Ala Val Asn Tyr Glu Phe Glu Asp Glu Tyr 
225                 230                 235                 240 
Phe Ser Asn Thr Ser Ala Leu Ala Lys Asp Phe Ile Arg Arg Leu Leu 
                245                 250                 255     
Val Lys Asp Pro Lys Lys Arg Met Thr Ile Gln Asp Ser Leu Gln His 
            260                 265                 270         
Pro Trp Ile Lys Pro Lys Asp Thr Gln Gln Ala Leu Ser Arg Lys Ala 
        275                 280                 285             
Ser Ala Val Asn Met Glu Lys Phe Lys Lys Phe Ala Ala Arg Lys Lys 
    290                 295                 300                 
Trp Lys Gln Ser Val Arg Leu Ile Ser Leu Cys Gln Arg Leu Ser Arg 
305                 310                 315                 320 
Ser Phe Leu Ser Arg Ser Asn Met Ser Val Ala Arg Ser Asp Asp Thr 
                325                 330                 335     
Leu Asp Glu Glu Asp Ser Phe Val Met Lys Ala Ile Ile His Ala Ile 
            340                 345                 350         
Asn Asp Asp Asn Val Pro Gly Leu Gln His Leu Leu Gly Ser Leu Ser 
        355                 360                 365             
Asn Tyr Asp Val Asn Gln Pro Asn Lys His Gly Thr Pro Pro Leu Leu 
    370                 375                 380                 
Ile Ala Ala Gly Cys Gly Asn Ile Gln Ile Leu Gln Leu Leu Ile Lys 
385                 390                 395                 400 
Arg Gly Ser Arg Ile Asp Val Gln Asp Lys Gly Gly Ser Asn Ala Val 
                405                 410                 415     
Tyr Trp Ala Ala Arg His Gly His Val Asp Thr Leu Lys Phe Leu Ser 
            420                 425                 430         
Glu Asn Lys Cys Pro Leu Asp Val Lys Asp Lys Ser Gly Glu Met Ala 
        435                 440                 445             
Leu His Val Ala Ala Arg Tyr Gly His Ala Asp Val Ala Gln Leu Leu 
    450                 455                 460                 
Cys Ser Phe Gly Ser Asn Pro Asn Ile Gln Asp Lys Glu Glu Glu Thr 
465                 470                 475                 480 
Pro Leu His Cys Ala Ala Trp His Gly Tyr Tyr Ser Val Ala Lys Ala 
                485                 490                 495     
Leu Cys Glu Ala Gly Cys Asn Val Asn Ile Lys Asn Arg Glu Gly Glu 
            500                 505                 510         
Thr Pro Leu Leu Thr Ala Ser Ala Arg Gly Tyr His Asp Ile Val Glu 
        515                 520                 525             
Cys Leu Ala Glu His Gly Ala Asp Leu Asn Ala Cys Asp Lys Asp Gly 
    530                 535                 540                 
His Ile Ala Leu His Leu Ala Val Arg Arg Cys Gln Met Glu Val Ile 
545                 550                 555                 560 
Lys Thr Leu Leu Ser Gln Gly Cys Phe Val Asp Tyr Gln Asp Arg His 
                565                 570                 575     
Gly Asn Thr Pro Leu His Val Ala Cys Lys Asp Gly Asn Met Pro Ile 
            580                 585                 590         
Val Val Ala Leu Cys Glu Ala Asn Cys Asn Leu Asp Ile Ser Asn Lys 
        595                 600                 605             
Tyr Gly Arg Thr Pro Leu His Leu Ala Ala Asn Asn Gly Ile Leu Asp 
    610                 615                 620                 
Val Val Arg Tyr Leu Cys Leu Met Gly Ala Ser Val Glu Ala Leu Thr 
625                 630                 635                 640 
Thr Asp Gly Lys Thr Ala Glu Asp Leu Ala Arg Ser Glu Gln His Glu 
                645                 650                 655     
His Val Ala Gly Leu Leu Ala Arg Leu Arg Lys Asp Thr His Arg Gly 
            660                 665                 670         
Leu Phe Ile Gln Gln Leu Arg Pro Thr Gln Asn Leu Gln Pro Arg Ile 
        675                 680                 685             
Lys Leu Lys Leu Phe Gly His Ser Gly Ser Gly Lys Thr Thr Leu Val 
    690                 695                 700                 
Glu Ser Leu Lys Cys Gly Leu Leu Arg Ser Phe Phe Arg Arg Arg Arg 
705                 710                 715                 720 
Pro Arg Leu Ser Ser Thr Asn Ser Ser Arg Phe Pro Pro Ser Pro Leu 
                725                 730                 735     
Ala Ser Lys Pro Thr Val Ser Val Ser Ile Asn Asn Leu Tyr Pro Gly 
            740                 745                 750         
Cys Glu Asn Val Ser Val Arg Ser Arg Ser Met Met Phe Glu Pro Gly 
        755                 760                 765             
Leu Thr Lys Gly Met Leu Glu Val Phe Val Ala Pro Thr His His Pro 
    770                 775                 780                 
His Cys Ser Ala Asp Asp Gln Ser Thr Lys Ala Ile Asp Ile Gln Asn 
785                 790                 795                 800 
Ala Tyr Leu Asn Gly Val Gly Asp Phe Ser Val Trp Glu Phe Ser Gly 
                805                 810                 815     
Asn Pro Val Tyr Phe Cys Cys Tyr Asp Tyr Phe Ala Ala Asn Asp Pro 
            820                 825                 830         
Thr Ser Ile His Val Val Val Phe Ser Leu Glu Glu Pro Tyr Glu Ile 
        835                 840                 845             
Gln Leu Asn Gln Val Ile Phe Trp Leu Ser Phe Leu Lys Ser Leu Val 
    850                 855                 860                 
Pro Val Glu Glu Pro Ile Ala Phe Gly Gly Lys Leu Lys Asn Pro Leu 
865                 870                 875                 880 
Gln Val Val Leu Val Ala Thr His Ala Asp Ile Met Asn Val Pro Arg 
                885                 890                 895     
Pro Ala Gly Gly Glu Phe Gly Tyr Asp Lys Asp Thr Ser Leu Leu Lys 
            900                 905                 910         
Glu Ile Arg Asn Arg Phe Gly Asn Asp Leu His Ile Ser Asn Lys Leu 
        915                 920                 925             
Phe Val Leu Asp Ala Gly Ala Ser Gly Ser Lys Asp Met Lys Val Leu 
    930                 935                 940                 
Arg Asn His Leu Gln Glu Ile Arg Ser Gln Ile Val Ser Val Cys Pro 
945                 950                 955                 960 
Pro Met Thr His Leu Cys Glu Lys Ile Ile Ser Thr Leu Pro Ser Trp 
                965                 970                 975     
Arg Lys Leu Asn Gly Pro Asn Gln Leu Met Ser Leu Gln Gln Phe Val 
            980                 985                 990         
Tyr Asp Val Gln Asp Gln Leu Asn  Pro Leu Ala Ser Glu  Glu Asp Leu 
        995                 1000                 1005             
Arg Arg  Ile Ala Gln Gln Leu  His Ser Thr Gly Glu  Ile Asn Ile 
    1010                 1015                 1020             
Met Gln  Ser Glu Thr Val Gln  Asp Val Leu Leu Leu  Asp Pro Arg 
    1025                 1030                 1035             
Trp Leu  Cys Thr Asn Val Leu  Gly Lys Leu Leu Ser  Val Glu Thr 
    1040                 1045                 1050             
Pro Arg  Ala Leu His His Tyr  Arg Gly Arg Tyr Thr  Val Glu Asp 
    1055                 1060                 1065             
Ile Gln  Arg Leu Val Pro Asp  Ser Asp Val Glu Glu  Leu Leu Gln 
    1070                 1075                 1080             
Ile Leu  Asp Ala Met Asp Ile  Cys Ala Arg Asp Leu  Ser Ser Gly 
    1085                 1090                 1095             
Thr Met  Val Asp Val Pro Ala  Leu Ile Lys Thr Asp  Asn Leu His 
    1100                 1105                 1110             
Arg Ser  Trp Ala Asp Glu Glu  Asp Glu Val Met Val  Tyr Gly Gly 
    1115                 1120                 1125             
Val Arg  Ile Val Pro Val Glu  His Leu Thr Pro Phe  Pro Cys Gly 
    1130                 1135                 1140             
Ile Phe  His Lys Val Gln Val  Asn Leu Cys Arg Trp  Ile His Gln 
    1145                 1150                 1155             
Gln Ser  Thr Glu Gly Asp Ala  Asp Ile Arg Leu Trp  Val Asn Gly 
    1160                 1165                 1170             
Cys Lys  Leu Ala Asn Arg Gly  Ala Glu Leu Leu Val  Leu Leu Val 
    1175                 1180                 1185             
Asn His  Gly Gln Gly Ile Glu  Val Gln Val Arg Gly  Leu Glu Thr 
    1190                 1195                 1200             
Glu Lys  Ile Lys Cys Cys Leu  Leu Leu Asp Ser Val  Cys Ser Thr 
    1205                 1210                 1215             
Ile Glu  Asn Val Met Ala Thr  Thr Leu Pro Gly Leu  Leu Thr Val 
    1220                 1225                 1230             
Lys His  Tyr Leu Ser Pro Gln  Gln Leu Arg Glu His  His Glu Pro 
    1235                 1240                 1245             
Val Met  Ile Tyr Gln Pro Arg  Asp Phe Phe Arg Ala  Gln Thr Leu 
    1250                 1255                 1260             
Lys Glu  Thr Ser Leu Thr Asn  Thr Met Gly Gly Tyr  Lys Glu Ser 
    1265                 1270                 1275             
Phe Ser  Ser Ile Met Cys Phe  Gly Cys His Asp Val  Tyr Ser Gln 
    1280                 1285                 1290             
Ala Ser  Leu Gly Met Asp Ile  His Ala Ser Asp Leu  Asn Leu Leu 
    1295                 1300                 1305             
Thr Arg  Arg Lys Leu Ser Arg  Leu Leu Asp Pro Pro  Asp Pro Leu 
    1310                 1315                 1320             
Gly Lys  Asp Trp Cys Leu Leu  Ala Met Asn Leu Gly  Leu Pro Asp 
    1325                 1330                 1335             
Leu Val  Ala Lys Tyr Asn Thr  Ser Asn Gly Ala Pro  Lys Asp Phe 
    1340                 1345                 1350             
Leu Pro  Ser Pro Leu His Ala  Leu Leu Arg Glu Trp  Thr Thr Tyr 
    1355                 1360                 1365             
Pro Glu  Ser Thr Val Gly Thr  Leu Met Ser Lys Leu  Arg Glu Leu 
    1370                 1375                 1380             
Gly Arg  Arg Asp Ala Ala Asp  Phe Leu Leu Lys Ala  Ser Ser Val 
    1385                 1390                 1395             
Phe Lys  Ile Asn Leu Asp Gly  Asn Gly Gln Glu Ala  Tyr Ala Ser 
    1400                 1405                 1410             
Ser Cys  Asn Ser Gly Thr Ser  Tyr Asn Ser Ile Ser  Ser Val Val 
    1415                 1420                 1425             
Ser Arg  
    1430 

<210>  3
<211>  21
<212>  RNA
<213>  ˹

<220>
<223>  ϳ

<400>  3
caagaaacgu uagcaaaugu u                                                 21


<210>  4
<211>  21
<212>  RNA
<213>  ˹

<220>
<223>  ϳ

<400>  4
cauuugcuaa cguuucuugu u                                                 21


<210>  5
<211>  21
<212>  RNA
<213>  ˹

<220>
<223>  ϳ

<400>  5
ggucaaggau ccaaagaagu u                                                 21


<210>  6
<211>  21
<212>  RNA
<213>  ˹

<220>
<223>  ϳ

<400>  6
cuucuuugga uccuugaccu u                                                 21
