                         SEQUENCE LISTING

<110>  AskGene Pharma, Inc.
       Yuefeng, Lu
       Jian-Feng, Lu
       Aijun, Wang
 
<120>  Fusion Proteins With Dual Receptor Agonist Activities

<130>  3IPAG3.0004WO

<150>  US 62/079,518
<151>  2014-11-13

<160>  76    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequence


<220>
<221>  Repeat
<222>  (1)..(5)
<223>  Sequence may be repeated 2, 3, or 4 times

<400>  1

Gly Gly Gly Gly Ser 
1               5   


<210>  2
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Ser Ile Tyr Phe Val Ala Gly Leu Phe Val Met Leu Val Gln 
1               5                   10                  15      


Gly Ser Trp Gln Arg Ser Leu Gln Asp Thr Glu Glu Lys Ser Arg Ser 
            20                  25                  30          


Phe Ser Ala Ser Gln Ala Asp Pro Leu Ser Asp Pro Asp Gln Met Asn 
        35                  40                  45              


Glu Asp Lys Arg His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys 
    50                  55                  60                  


Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn 
65                  70                  75                  80  


Thr Lys Arg Asn Arg Asn Asn Ile Ala Lys Arg His Asp Glu Phe Glu 
                85                  90                  95      


Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu 
            100                 105                 110         


Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
        115                 120                 125             


Arg Arg Asp Phe Pro Glu Glu Val Ala Ile Val Glu Glu Leu Gly Arg 
    130                 135                 140                 


Arg His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp 
145                 150                 155                 160 


Asn Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile 
                165                 170                 175     


Thr Asp Arg Lys 
            180 


<210>  3
<211>  37
<212>  PRT
<213>  homo sapiens

<400>  3

His Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 
1               5                   10                  15      


Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu 
            20                  25                  30          


Val Lys Gly Arg Gly 
        35          


<210>  4
<211>  37
<212>  PRT
<213>  homo sapiens

<400>  4

His Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 
1               5                   10                  15      


Ser Ser Tyr Leu Glu Gly Gln Val Ala Lys Glu Phe Ile Ala Trp Leu 
            20                  25                  30          


Val Lys Gly Arg Gly 
        35          


<210>  5
<211>  31
<212>  PRT
<213>  homo sapiens

<400>  5

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  6
<211>  31
<212>  PRT
<213>  homo sapiens

<400>  6

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Val Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  7
<211>  30
<212>  PRT
<213>  homo sapiens

<400>  7

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  8
<211>  30
<212>  PRT
<213>  homo sapiens

<400>  8

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Val Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  9
<211>  42
<212>  PRT
<213>  homo sapiens

<400>  9

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  10
<211>  39
<212>  PRT
<213>  homo sapiens

<400>  10

His Ser Asp Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  11
<211>  39
<212>  PRT
<213>  homo sapiens

<400>  11

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  12
<211>  29
<212>  PRT
<213>  homo sapiens

<400>  12

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  13
<211>  37
<212>  PRT
<213>  homo sapiens

<400>  13

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  14
<211>  31
<212>  PRT
<213>  artificial sequence

<220>
<223>  GLP-1 analogue


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  X may be aminoisobutyric acid (Aib), Gly, D-Ala, D-Ser, D-Gly, or
       D-Val

<400>  14

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Leu Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly 
            20                  25                  30      


<210>  15
<211>  31
<212>  PRT
<213>  artificial sequence

<220>
<223>  GLP-1 Analogue


<220>
<221>  variant
<222>  (2)..(2)
<223>  where X may be is selected from aminoisobutyric acid (Aib), Gly, 
       D-Ala, D-Ser, D-Gly, and D-Val.

<400>  15

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Leu Glu Phe Ile Ala Trp Leu Lys Asn Gly Gly Gly 
            20                  25                  30      


<210>  16
<211>  31
<212>  PRT
<213>  artificial sequence

<220>
<223>  GLP-1 Analogue


<220>
<221>  variant
<222>  (2)..(2)
<223>  wherein X is selected from aminoisobutyric acid (Aib), Gly, 
       D-Ala, D-Ser, D-Gly, and D-Val

<400>  16

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Leu Glu Phe Ile Ala Trp Leu Val Leu Gly Gly Pro 
            20                  25                  30      


<210>  17
<211>  31
<212>  PRT
<213>  artificial sequence

<220>
<223>  GLP-1 analogue


<220>
<221>  variant
<222>  (2)..(2)
<223>  wherein X is selected from Gly, aminoisobutyric acid 
       (Aib),D-Ala,D-Ser,D-Gly, and D-Val

<400>  17

His Xaa Glu Gly Thr Phe Thr Ser Ala Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Leu Glu Phe Ile Ala Trp Leu Lys Asn Gly Gly Pro 
            20                  25                  30      


<210>  18
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  GLP-1 Analogue


<220>
<221>  variant
<222>  (2)..(2)
<223>  wherein X is selected from Gly, aminoisobutyric acid 
       (Aib),D-Ala,D-Ser,D-Gly, and D-Val

<400>  18

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Leu Glu Phe Ile Ala Trp Leu Lys Asn Gly Gly 
            20                  25                  30  


<210>  19
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  GLP-1 Analogue


<220>
<221>  variant
<222>  (2)..(2)
<223>  wherein X is selected from Gly, aminoisobutyric acid 
       (Aib),D-Ala,D-Ser,D-Gly, and D-Val

<400>  19

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Leu Glu Phe Ile Ala Trp Leu Lys Asn Gly Gly 
            20                  25                  30  


<210>  20
<211>  42
<212>  PRT
<213>  artificial sequence

<220>
<223>  GIP Analogue


<220>
<221>  variant
<222>  (2)..(2)
<223>  wherein X is selected from Gly, Val, Lys, and Ser?aminoisobutyric
       acid (Aib), D-Ala, D-Ser, D-Gly, and D-Val

<400>  20

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  21
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  GIP Analogue


<220>
<221>  variant
<222>  (2)..(2)
<223>  wherein X is selected from Gly, Val, Lys, and Ser?aminoisobutyric
       acid (Aib), D-Ala, D-Ser, D-Gly, and D-Val

<400>  21

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  22
<211>  40
<212>  PRT
<213>  artificial sequence

<220>
<223>  Exendin analogue

<400>  22

His Ser Asp Gly Thr Phe Ile Thr Ser Asp Leu Ser Lys Gln Met Glu 
1               5                   10                  15      


Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40  


<210>  23
<211>  29
<212>  PRT
<213>  artificial sequence

<220>
<223>  oxyntomodulin analogue


<220>
<221>  variant
<222>  (2)..(2)
<223>  wherein X is aminoisobutyric acid

<400>  23

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  24
<211>  29
<212>  PRT
<213>  artificial sequence

<220>
<223>  oxyntomodulin analogue


<220>
<221>  variant
<222>  (2)..(2)
<223>  wherein X is an amino isobutyric acid

<400>  24

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  25
<211>  29
<212>  PRT
<213>  artificial sequence

<220>
<223>  oxyntomodulin analogue


<220>
<221>  variant
<222>  (2)..(2)
<223>  wherein X is an amino isobutyric acid

<400>  25

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  26
<211>  29
<212>  PRT
<213>  artificial sequence

<220>
<223>  oxyntomodulin analogue


<220>
<221>  variant
<222>  (2)..(2)
<223>  wherein X is an amino isobutyric acid

<400>  26

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  27
<211>  29
<212>  PRT
<213>  artificial sequence

<220>
<223>  oxyntomodulin analogue


<220>
<221>  variant
<222>  (1)..(1)
<223>  represents 4-imidazoacetyl

<220>
<221>  variant
<222>  (2)..(2)
<223>  wherein X is an amino isobutyric acid

<400>  27

Xaa Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  28
<211>  29
<212>  PRT
<213>  artificial sequence

<220>
<223>  oxyntomodulin analogue


<220>
<221>  variant
<222>  (2)..(2)
<223>  wherein X is an amino isobutyric acid

<400>  28

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ala Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  29
<211>  37
<212>  PRT
<213>  artificial sequence

<220>
<223>  oxyntomodulin analogue


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  where H at position 1 is histidine or D-histidine

<400>  29

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  30
<211>  29
<212>  PRT
<213>  artificial sequence

<220>
<223>  oxyntomodulin analogue


<220>
<221>  variant
<222>  (2)..(2)
<223>  wherein X is an amino isobutyric acid

<400>  30

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  31
<211>  327
<212>  PRT
<213>  homo sapiens

<400>  31

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  32
<211>  330
<212>  PRT
<213>  homo sapiens

<400>  32

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  33
<211>  326
<212>  PRT
<213>  homo sapiens

<400>  33

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  34
<211>  452
<212>  PRT
<213>  homo sapiens

<400>  34

Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Leu Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys 
            100                 105                 110         


Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg 
        115                 120                 125             


Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile 
    130                 135                 140                 


Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr 
145                 150                 155                 160 


Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr 
                165                 170                 175     


Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Gly Gln 
            180                 185                 190         


Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln 
        195                 200                 205             


Asn Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val 
    210                 215                 220                 


Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr 
225                 230                 235                 240 


Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr 
                245                 250                 255     


Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn 
            260                 265                 270         


Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala 
        275                 280                 285             


Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr 
    290                 295                 300                 


Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg 
305                 310                 315                 320 


Pro Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro 
                325                 330                 335     


Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu 
            340                 345                 350         


Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg 
        355                 360                 365             


Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro 
    370                 375                 380                 


Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val 
385                 390                 395                 400 


Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Ala His 
                405                 410                 415     


Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr 
            420                 425                 430         


Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala 
        435                 440                 445             


Gly Thr Cys Tyr 
    450         


<210>  35
<211>  230
<212>  PRT
<213>  artificial sequence

<220>
<223>  Variant Fc


<220>
<221>  variant
<222>  (16)..(16)
<223>  X at position 16 is Pro or Glu;

<220>
<221>  variant
<222>  (17)..(17)
<223>  X at position 17 is Phe, Val, or Ala;

<220>
<221>  variant
<222>  (18)..(18)
<223>  X at position 18 is Leu, Glu, or Ala;

<220>
<221>  variant
<222>  (33)..(33)
<223>  X at position 33 is Thr, Glu, or Gln

<220>
<221>  variant
<222>  (35)..(35)
<223>  X at position 35 is Met or Trp;

<220>
<221>  variant
<222>  (37)..(37)
<223>  X at position 37 is Ser or Thr;

<220>
<221>  variant
<222>  (39)..(39)
<223>  X at position 39 is Thr or Glu;

<220>
<221>  variant
<222>  (80)..(80)
<223>  X at position 80 is Asn or Ala;

<220>
<221>  variant
<222>  (188)..(188)
<223>  X at position 188 is Phe or Leu;

<220>
<221>  variant
<222>  (192)..(192)
<223>  X at position 192 is Lys or Arg;

<220>
<221>  variant
<222>  (211)..(211)
<223>  X at position 211 is Leu, Met, Ala or Phe;

<220>
<221>  variant
<222>  (217)..(217)
<223>  X at position 217 is Asn or Ser

<220>
<221>  variant
<222>  (230)..(230)
<223>  X at position 230 is Lys or is absent

<400>  35

Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Xaa 
1               5                   10                  15      


Xaa Xaa Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            20                  25                  30          


Xaa Leu Xaa Ile Xaa Arg Xaa Pro Glu Val Thr Cys Val Val Val Asp 
        35                  40                  45              


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
    50                  55                  60                  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Xaa 
65                  70                  75                  80  


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                85                  90                  95      


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
            100                 105                 110         


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        115                 120                 125             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
    130                 135                 140                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
145                 150                 155                 160 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                165                 170                 175     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Xaa Leu Tyr Ser Xaa 
            180                 185                 190         


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
        195                 200                 205             


Ser Val Xaa His Glu Ala Leu His Xaa His Tyr Thr Gln Lys Ser Leu 
    210                 215                 220                 


Ser Leu Ser Leu Gly Xaa 
225                 230 


<210>  36
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  GIP analogue Fc Fusion Protein


<220>
<221>  variant
<222>  (79)..(79)
<223>  X at position 79 is selected from T and Q

<220>
<221>  variant
<222>  (234)..(234)
<223>  X at position 234 is selected from F and L

<220>
<221>  variant
<222>  (238)..(238)
<223>  X at position 238 is selected from K and R

<220>
<221>  variant
<222>  (257)..(257)
<223>  X at position 257 is selected from L and M

<400>  36

Tyr Gly Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Ala Glu 
        35                  40                  45              


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Xaa Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Xaa Leu Tyr Ser Xaa Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Xaa His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly 
        275 


<210>  37
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  GLP-1 analogue Fc Fusion Peptide


<220>
<221>  variant
<222>  (79)..(79)
<223>  X at position 79 is selected from T and Q

<220>
<221>  variant
<222>  (234)..(234)
<223>  X at position 234 is selected from F and L

<220>
<221>  variant
<222>  (238)..(238)
<223>  X at position 238 is selected from K and R

<220>
<221>  variant
<222>  (257)..(257)
<223>  X at position 257 is selected from L and M

<400>  37

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Ala Glu 
        35                  40                  45              


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Xaa Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Xaa Leu Tyr Ser Xaa Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Xaa His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly 
        275 


<210>  38
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  GLP-1 containing fusion peptide

<400>  38

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Ala Glu 
        35                  40                  45              


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Leu Leu Tyr Ser Lys Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly 
        275 


<210>  39
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  GIP analogue containing fusion peptide

<400>  39

Tyr Gly Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Ala Glu 
        35                  40                  45              


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Leu Gly 
        275 


<210>  40
<211>  229
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fc region

<400>  40

Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu 
1               5                   10                  15      


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            20                  25                  30          


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        35                  40                  45              


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
    50                  55                  60                  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
65                  70                  75                  80  


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                85                  90                  95      


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
            100                 105                 110         


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        115                 120                 125             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
    130                 135                 140                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
145                 150                 155                 160 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                165                 170                 175     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Leu Leu Tyr Ser Lys 
            180                 185                 190         


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
        195                 200                 205             


Ser Val Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    210                 215                 220                 


Ser Leu Ser Leu Gly 
225                 


<210>  41
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  41

Lys Arg Asn Arg Asn Asn Ile Ala 
1               5               


<210>  42
<211>  98
<212>  PRT
<213>  homo sapiens

<400>  42

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val 
        


<210>  43
<211>  110
<212>  PRT
<213>  homo sapiens

<400>  43

Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  44
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  44

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            100                 105         


<210>  45
<211>  208
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG4 Ch1 and CH2, no hinge

<400>  45

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            100                 105                 110         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        115                 120                 125             


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
    130                 135                 140                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
145                 150                 155                 160 


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                165                 170                 175     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            180                 185                 190         


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        195                 200                 205             


<210>  46
<211>  205
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG4 CH1 and CH3, no hinge

<400>  46

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        195                 200                 205 


<210>  47
<211>  217
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG4 CH2 and CH3, no hinge

<400>  47

Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    210                 215         


<210>  48
<211>  98
<212>  PRT
<213>  homo sapiens

<400>  48

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val 
        


<210>  49
<211>  113
<212>  PRT
<213>  homo sapiens

<400>  49

Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
1               5                   10                  15      


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            20                  25                  30          


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        35                  40                  45              


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    50                  55                  60                  


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
65                  70                  75                  80  


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                85                  90                  95      


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            100                 105                 110         


Lys 
    


<210>  50
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  50

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  51
<211>  211
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG1 CH1 and CH2 (no hinge)

<400>  51

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
            100                 105                 110         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        115                 120                 125             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    130                 135                 140                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
145                 150                 155                 160 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                165                 170                 175     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            180                 185                 190         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        195                 200                 205             


Lys Ala Lys 
    210     


<210>  52
<211>  205
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG1 CH1 and CH3 (no hinge)

<400>  52

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210>  53
<211>  220
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG1 CH2 and CH3 (no hinge)

<400>  53

Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
1               5                   10                  15      


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            20                  25                  30          


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        35                  40                  45              


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    50                  55                  60                  


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
65                  70                  75                  80  


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                85                  90                  95      


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            100                 105                 110         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        115                 120                 125             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    130                 135                 140                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
145                 150                 155                 160 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                165                 170                 175     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            180                 185                 190         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220 


<210>  54
<211>  98
<212>  PRT
<213>  homo sapiens

<400>  54

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val 
        


<210>  55
<211>  109
<212>  PRT
<213>  homo sapiens

<400>  55

Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
1               5                   10                  15      


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            20                  25                  30          


Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
        35                  40                  45              


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    50                  55                  60                  


Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln 
65                  70                  75                  80  


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
                85                  90                  95      


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
            100                 105                 


<210>  56
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  56

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  57
<211>  207
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG2 CH1 and CH2 no hinge

<400>  57

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
            100                 105                 110         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        115                 120                 125             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp 
    130                 135                 140                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
145                 150                 155                 160 


Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val 
                165                 170                 175     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            180                 185                 190         


Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
        195                 200                 205         


<210>  58
<211>  205
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG2 CH1 and CH3 no hinge

<400>  58

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210>  59
<211>  216
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG2 CH2 and CH3 no hinge

<400>  59

Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
1               5                   10                  15      


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            20                  25                  30          


Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
        35                  40                  45              


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    50                  55                  60                  


Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln 
65                  70                  75                  80  


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
                85                  90                  95      


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro 
            100                 105                 110         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        115                 120                 125             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    130                 135                 140                 


Asp Ile Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
145                 150                 155                 160 


Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                165                 170                 175     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            180                 185                 190         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        195                 200                 205             


Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215     


<210>  60
<211>  105
<212>  PRT
<213>  homo sapiens

<400>  60

Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Leu Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro Val 
            100                 105 


<210>  61
<211>  112
<212>  PRT
<213>  homo sapiens

<400>  61

Ile Ala Glu Leu Pro Pro Lys Val Ser Val Phe Val Pro Pro Arg Asp 
1               5                   10                  15      


Gly Phe Phe Gly Asn Pro Arg Lys Ser Lys Leu Ile Cys Gln Ala Thr 
            20                  25                  30          


Gly Phe Ser Pro Arg Gln Ile Gln Val Ser Trp Leu Arg Glu Gly Lys 
        35                  40                  45              


Gln Val Gly Ser Gly Val Thr Thr Asp Gln Val Gln Ala Glu Ala Lys 
    50                  55                  60                  


Glu Ser Gly Pro Thr Thr Tyr Lys Val Thr Ser Thr Leu Thr Ile Lys 
65                  70                  75                  80  


Glu Ser Asp Trp Leu Gly Gln Ser Met Phe Thr Cys Arg Val Asp His 
                85                  90                  95      


Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser Met Cys Val Pro Asp 
            100                 105                 110         


<210>  62
<211>  106
<212>  PRT
<213>  homo sapiens

<400>  62

Gln Asp Thr Ala Ile Arg Val Phe Ala Ile Pro Pro Ser Phe Ala Ser 
1               5                   10                  15      


Ile Phe Leu Thr Lys Ser Thr Lys Leu Thr Cys Leu Val Thr Asp Leu 
            20                  25                  30          


Thr Thr Tyr Asp Ser Val Thr Ile Ser Trp Thr Arg Gln Asn Gly Glu 
        35                  40                  45              


Ala Val Lys Thr His Thr Asn Ile Ser Glu Ser His Pro Asn Ala Thr 
    50                  55                  60                  


Phe Ser Ala Val Gly Glu Ala Ser Ile Cys Glu Asp Asp Trp Asn Ser 
65                  70                  75                  80  


Gly Glu Arg Phe Thr Cys Thr Val Thr His Thr Asp Leu Pro Ser Pro 
                85                  90                  95      


Leu Lys Gln Thr Ile Ser Arg Pro Lys Gly 
            100                 105     


<210>  63
<211>  129
<212>  PRT
<213>  homo sapiens

<400>  63

Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro Ala Arg Glu 
1               5                   10                  15      


Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu Val Thr Gly 
            20                  25                  30          


Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg Gly Gln Pro 
        35                  40                  45              


Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro Glu Pro Gln 
    50                  55                  60                  


Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val Ser Glu Glu 
65                  70                  75                  80  


Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Ala His Glu Ala Leu 
                85                  90                  95      


Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr Gly Lys Pro 
            100                 105                 110         


Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys 
        115                 120                 125             


Tyr 
    


<210>  64
<211>  217
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgM: CH1 and CH2

<400>  64

Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Leu Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys 
            100                 105                 110         


Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg 
        115                 120                 125             


Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile 
    130                 135                 140                 


Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr 
145                 150                 155                 160 


Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr 
                165                 170                 175     


Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Gly Gln 
            180                 185                 190         


Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln 
        195                 200                 205             


Asn Ala Ser Ser Met Cys Val Pro Asp 
    210                 215         


<210>  65
<211>  211
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgM: CH1 and CH3

<400>  65

Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Leu Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro Val Gln Asp Thr Ala Ile Arg Val 
            100                 105                 110         


Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr 
        115                 120                 125             


Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr 
    130                 135                 140                 


Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn 
145                 150                 155                 160 


Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala 
                165                 170                 175     


Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr 
            180                 185                 190         


Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg 
        195                 200                 205             


Pro Lys Gly 
    210     


<210>  66
<211>  234
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgM CH1 and CH4

<400>  66

Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Leu Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro Val Val Ala Leu His Arg Pro Asp 
            100                 105                 110         


Val Tyr Leu Leu Pro Pro Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser 
        115                 120                 125             


Ala Thr Ile Thr Cys Leu Val Thr Gly Phe Ser Pro Ala Asp Val Phe 
    130                 135                 140                 


Val Gln Trp Met Gln Arg Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val 
145                 150                 155                 160 


Thr Ser Ala Pro Met Pro Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala 
                165                 170                 175     


His Ser Ile Leu Thr Val Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr 
            180                 185                 190         


Tyr Thr Cys Val Ala His Glu Ala Leu Pro Asn Arg Val Thr Glu Arg 
        195                 200                 205             


Thr Val Asp Lys Ser Thr Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu 
    210                 215                 220                 


Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
225                 230                 


<210>  67
<211>  340
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgM CH1-CH3-CH4

<400>  67

Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Leu Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro Val Gln Asp Thr Ala Ile Arg Val 
            100                 105                 110         


Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr 
        115                 120                 125             


Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr 
    130                 135                 140                 


Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn 
145                 150                 155                 160 


Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala 
                165                 170                 175     


Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr 
            180                 185                 190         


Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg 
        195                 200                 205             


Pro Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro 
    210                 215                 220                 


Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu 
225                 230                 235                 240 


Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg 
                245                 250                 255     


Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro 
            260                 265                 270         


Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val 
        275                 280                 285             


Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Ala His 
    290                 295                 300                 


Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr 
305                 310                 315                 320 


Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala 
                325                 330                 335     


Gly Thr Cys Tyr 
            340 


<210>  68
<211>  346
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgM CH1-CH2-CH4

<400>  68

Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Leu Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys 
            100                 105                 110         


Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg 
        115                 120                 125             


Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile 
    130                 135                 140                 


Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr 
145                 150                 155                 160 


Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr 
                165                 170                 175     


Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Gly Gln 
            180                 185                 190         


Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln 
        195                 200                 205             


Asn Ala Ser Ser Met Cys Val Pro Asp Val Ala Leu His Arg Pro Asp 
    210                 215                 220                 


Val Tyr Leu Leu Pro Pro Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser 
225                 230                 235                 240 


Ala Thr Ile Thr Cys Leu Val Thr Gly Phe Ser Pro Ala Asp Val Phe 
                245                 250                 255     


Val Gln Trp Met Gln Arg Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val 
            260                 265                 270         


Thr Ser Ala Pro Met Pro Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala 
        275                 280                 285             


His Ser Ile Leu Thr Val Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr 
    290                 295                 300                 


Tyr Thr Cys Val Ala His Glu Ala Leu Pro Asn Arg Val Thr Glu Arg 
305                 310                 315                 320 


Thr Val Asp Lys Ser Thr Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu 
                325                 330                 335     


Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
            340                 345     


<210>  69
<211>  218
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgM CH2-CH3

<400>  69

Ile Ala Glu Leu Pro Pro Lys Val Ser Val Phe Val Pro Pro Arg Asp 
1               5                   10                  15      


Gly Phe Phe Gly Asn Pro Arg Lys Ser Lys Leu Ile Cys Gln Ala Thr 
            20                  25                  30          


Gly Phe Ser Pro Arg Gln Ile Gln Val Ser Trp Leu Arg Glu Gly Lys 
        35                  40                  45              


Gln Val Gly Ser Gly Val Thr Thr Asp Gln Val Gln Ala Glu Ala Lys 
    50                  55                  60                  


Glu Ser Gly Pro Thr Thr Tyr Lys Val Thr Ser Thr Leu Thr Ile Lys 
65                  70                  75                  80  


Glu Ser Asp Trp Leu Gly Gln Ser Met Phe Thr Cys Arg Val Asp His 
                85                  90                  95      


Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser Met Cys Val Pro Asp 
            100                 105                 110         


Gln Asp Thr Ala Ile Arg Val Phe Ala Ile Pro Pro Ser Phe Ala Ser 
        115                 120                 125             


Ile Phe Leu Thr Lys Ser Thr Lys Leu Thr Cys Leu Val Thr Asp Leu 
    130                 135                 140                 


Thr Thr Tyr Asp Ser Val Thr Ile Ser Trp Thr Arg Gln Asn Gly Glu 
145                 150                 155                 160 


Ala Val Lys Thr His Thr Asn Ile Ser Glu Ser His Pro Asn Ala Thr 
                165                 170                 175     


Phe Ser Ala Val Gly Glu Ala Ser Ile Cys Glu Asp Asp Trp Asn Ser 
            180                 185                 190         


Gly Glu Arg Phe Thr Cys Thr Val Thr His Thr Asp Leu Pro Ser Pro 
        195                 200                 205             


Leu Lys Gln Thr Ile Ser Arg Pro Lys Gly 
    210                 215             


<210>  70
<211>  241
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgM CH2-CH4

<400>  70

Ile Ala Glu Leu Pro Pro Lys Val Ser Val Phe Val Pro Pro Arg Asp 
1               5                   10                  15      


Gly Phe Phe Gly Asn Pro Arg Lys Ser Lys Leu Ile Cys Gln Ala Thr 
            20                  25                  30          


Gly Phe Ser Pro Arg Gln Ile Gln Val Ser Trp Leu Arg Glu Gly Lys 
        35                  40                  45              


Gln Val Gly Ser Gly Val Thr Thr Asp Gln Val Gln Ala Glu Ala Lys 
    50                  55                  60                  


Glu Ser Gly Pro Thr Thr Tyr Lys Val Thr Ser Thr Leu Thr Ile Lys 
65                  70                  75                  80  


Glu Ser Asp Trp Leu Gly Gln Ser Met Phe Thr Cys Arg Val Asp His 
                85                  90                  95      


Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser Met Cys Val Pro Asp 
            100                 105                 110         


Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro Ala Arg Glu 
        115                 120                 125             


Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu Val Thr Gly 
    130                 135                 140                 


Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg Gly Gln Pro 
145                 150                 155                 160 


Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro Glu Pro Gln 
                165                 170                 175     


Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val Ser Glu Glu 
            180                 185                 190         


Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Ala His Glu Ala Leu 
        195                 200                 205             


Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr Gly Lys Pro 
    210                 215                 220                 


Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys 
225                 230                 235                 240 


Tyr 
    


<210>  71
<211>  346
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgM CH2-CH3-CH4

<400>  71

Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Leu Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys 
            100                 105                 110         


Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg 
        115                 120                 125             


Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile 
    130                 135                 140                 


Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr 
145                 150                 155                 160 


Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr 
                165                 170                 175     


Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Gly Gln 
            180                 185                 190         


Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln 
        195                 200                 205             


Asn Ala Ser Ser Met Cys Val Pro Asp Val Ala Leu His Arg Pro Asp 
    210                 215                 220                 


Val Tyr Leu Leu Pro Pro Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser 
225                 230                 235                 240 


Ala Thr Ile Thr Cys Leu Val Thr Gly Phe Ser Pro Ala Asp Val Phe 
                245                 250                 255     


Val Gln Trp Met Gln Arg Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val 
            260                 265                 270         


Thr Ser Ala Pro Met Pro Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala 
        275                 280                 285             


His Ser Ile Leu Thr Val Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr 
    290                 295                 300                 


Tyr Thr Cys Val Ala His Glu Ala Leu Pro Asn Arg Val Thr Glu Arg 
305                 310                 315                 320 


Thr Val Asp Lys Ser Thr Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu 
                325                 330                 335     


Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
            340                 345     


<210>  72
<211>  129
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgM CH3-CH4

<400>  72

Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro Ala Arg Glu 
1               5                   10                  15      


Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu Val Thr Gly 
            20                  25                  30          


Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg Gly Gln Pro 
        35                  40                  45              


Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro Glu Pro Gln 
    50                  55                  60                  


Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val Ser Glu Glu 
65                  70                  75                  80  


Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Ala His Glu Ala Leu 
                85                  90                  95      


Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr Gly Lys Pro 
            100                 105                 110         


Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys 
        115                 120                 125             


Tyr 
    


<210>  73
<211>  908
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding the fusion protein ASKBH2

<400>  73
aagcttgccg ccaccatgga acgacattgg attttccttt tcctcttctc tgtcaccgcc       60

ggagtgcata gccacggaga gggaaccttc accagcgacg tgtcctccta cctggaagaa      120

caggccgcta aggagtttat cgcgtggttg gtcaagggtg gaggcggcgg gggagggtcc      180

ggcggcggag gctcaggcgg agggggctcc gcagagtcaa aatatgggcc gccctgcccg      240

ccgtgcccag ccccggaggc cgcgggcggt ccgagcgtgt ttttgttccc gcctaaaccg      300

aaggaccagc tgatgatttc ccgcactcct gaagtcacct gtgtggtggt ggacgtgtca      360

caagaggacc ccgaagtgca gttcaattgg tacgtcgacg gagtggaagt gcacaacgcc      420

aagactaagc ctcgcgagga gcagttcaac tccacgtacc gggtcgtgtc agtgcttact      480

gtgctgcacc aggattggct gaacggaaag gagtacaagt gcaaagtgtc caacaagggg      540

ctcccatcgt cgatcgaaaa gactatctcc aaggccaagg gtcaacctcg ggagccacaa      600

gtctacaccc tgcccccgag ccaggaagag atgaccaaga accaagtgtc cctgacatgt      660

ctcgtgaagg ggttctaccc ctccgacatc gcggtggaat gggaatcgaa cggacagccc      720

gaaaacaact acaagaccac cccccctgtc ctggatagcg atggcagctt cttcctgtac      780

tcgagactca ccgtggacaa gtcgcggtgg caggagggca acgtgttcag ctgctccgtg      840

ctgcacgaag ccctgcacaa ccactacacc caaaagtccc tgtccctgag cctgggatag      900

ttaattaa                                                               908


<210>  74
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein ASKBH2

<400>  74

Met Glu Arg His Trp Ile Phe Leu Phe Leu Phe Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr 
            20                  25                  30          


Leu Glu Glu Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
        35                  40                  45              


Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
65                  70                  75                  80  


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                85                  90                  95      


Asp Gln Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            100                 105                 110         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        115                 120                 125             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    130                 135                 140                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
145                 150                 155                 160 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                165                 170                 175     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            180                 185                 190         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        195                 200                 205             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    210                 215                 220                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
225                 230                 235                 240 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                245                 250                 255     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            260                 265                 270         


Cys Ser Val Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        275                 280                 285             


Leu Ser Leu Ser Leu Gly 
    290                 


<210>  75
<211>  908
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding the fusion protein ASKBH3

<400>  75
aagcttgccg ccaccatgga acgacattgg attttccttt tcctcttctc tgtcaccgcc       60

ggagtgcata gccacggaga gggaaccttc accagcgacg tgtcctccta cctggaagaa      120

caggccgcta aggagtttat cgcgtggttg gtcaagggtg gaggcggcgg gggagggtcc      180

ggcggcggag gctcaggcgg agggggctcc gcagagtcaa aatatgggcc gccctgcccg      240

ccgtgcccag ccccggaggc cgcgggcggt ccgagcgtgt ttttgttccc gcctaaaccg      300

aaggacactc tgatgatttc ccgcactcct gaagtcacct gtgtggtggt ggacgtgtca      360

caagaggacc ccgaagtgca gttcaattgg tacgtcgacg gagtggaagt gcacaacgcc      420

aagactaagc ctcgcgagga gcagttcaac tccacgtacc gggtcgtgtc agtgcttact      480

gtgctgcacc aggattggct gaacggaaag gagtacaagt gcaaagtgtc caacaagggg      540

ctcccatcgt cgatcgaaaa gactatctcc aaggccaagg gtcaacctcg ggagccacaa      600

gtctacaccc tgcccccgag ccaggaagag atgaccaaga accaagtgtc cctgacatgt      660

ctcgtgaagg ggttctaccc ctccgacatc gcggtggaat gggaatcgaa cggacagccc      720

gaaaacaact acaagaccac cccccctgtc ctggatagcg atggcagctt cttcctgtac      780

tcgaagctca ccgtggacaa gtcgcggtgg caggagggca acgtgttcag ctgctccgtg      840

ctgcacgaag ccctgcacaa ccactacacc caaaagtccc tgtccctgag cctgggatag      900

ttaattaa                                                               908


<210>  76
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein ASKBH3

<400>  76

Met Glu Arg His Trp Ile Phe Leu Phe Leu Phe Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr 
            20                  25                  30          


Leu Glu Glu Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
        35                  40                  45              


Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
65                  70                  75                  80  


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                85                  90                  95      


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            100                 105                 110         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        115                 120                 125             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    130                 135                 140                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
145                 150                 155                 160 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                165                 170                 175     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            180                 185                 190         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        195                 200                 205             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    210                 215                 220                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
225                 230                 235                 240 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                245                 250                 255     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            260                 265                 270         


Cys Ser Val Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        275                 280                 285             


Leu Ser Leu Ser Leu Gly 
    290                 


