                               SEQUENCE LISTING

<110> MEMORIAL SLOAN KETTERING CANCER CENTER
 
<120> ANTI-CHONDROITIN SULFATE PROTEOGLYCAN 4 ANTIBODIES AND USES 
      THEREOF

<130> 2003080-1030

<140> PCT/US2015/060465
<141> 2015-11-12

<150> 62/078,849
<151> 2014-11-12

<160> 23    

<170> PatentIn version 3.5

<210> 1
<211> 2322
<212> PRT
<213> Homo sapiens

<400> 1
Met Gln Ser Gly Pro Arg Pro Pro Leu Pro Ala Pro Gly Leu Ala Leu 
1               5                   10                  15      


Ala Leu Thr Leu Thr Met Leu Ala Arg Leu Ala Ser Ala Ala Ser Phe 
            20                  25                  30          


Phe Gly Glu Asn His Leu Glu Val Pro Val Ala Thr Ala Leu Thr Asp 
        35                  40                  45              


Ile Asp Leu Gln Leu Gln Phe Ser Thr Ser Gln Pro Glu Ala Leu Leu 
    50                  55                  60                  


Leu Leu Ala Ala Gly Pro Ala Asp His Leu Leu Leu Gln Leu Tyr Ser 
65                  70                  75                  80  


Gly Arg Leu Gln Val Arg Leu Val Leu Gly Gln Glu Glu Leu Arg Leu 
                85                  90                  95      


Gln Thr Pro Ala Glu Thr Leu Leu Ser Asp Ser Ile Pro His Thr Val 
            100                 105                 110         


Val Leu Thr Val Val Glu Gly Trp Ala Thr Leu Ser Val Asp Gly Phe 
        115                 120                 125             


Leu Asn Ala Ser Ser Ala Val Pro Gly Ala Pro Leu Glu Val Pro Tyr 
    130                 135                 140                 


Gly Leu Phe Val Gly Gly Thr Gly Thr Leu Gly Leu Pro Tyr Leu Arg 
145                 150                 155                 160 


Gly Thr Ser Arg Pro Leu Arg Gly Cys Leu His Ala Ala Thr Leu Asn 
                165                 170                 175     


Gly Arg Ser Leu Leu Arg Pro Leu Thr Pro Asp Val His Glu Gly Cys 
            180                 185                 190         


Ala Glu Glu Phe Ser Ala Ser Asp Asp Val Ala Leu Gly Phe Ser Gly 
        195                 200                 205             


Pro His Ser Leu Ala Ala Phe Pro Ala Trp Gly Thr Gln Asp Glu Gly 
    210                 215                 220                 


Thr Leu Glu Phe Thr Leu Thr Thr Gln Ser Arg Gln Ala Pro Leu Ala 
225                 230                 235                 240 


Phe Gln Ala Gly Gly Arg Arg Gly Asp Phe Ile Tyr Val Asp Ile Phe 
                245                 250                 255     


Glu Gly His Leu Arg Ala Val Val Glu Lys Gly Gln Gly Thr Val Leu 
            260                 265                 270         


Leu His Asn Ser Val Pro Val Ala Asp Gly Gln Pro His Glu Val Ser 
        275                 280                 285             


Val His Ile Asn Ala His Arg Leu Glu Ile Ser Val Asp Gln Tyr Pro 
    290                 295                 300                 


Thr His Thr Ser Asn Arg Gly Val Leu Ser Tyr Leu Glu Pro Arg Gly 
305                 310                 315                 320 


Ser Leu Leu Leu Gly Gly Leu Asp Ala Glu Ala Ser Arg His Leu Gln 
                325                 330                 335     


Glu His Arg Leu Gly Leu Thr Pro Glu Ala Thr Asn Ala Ser Leu Leu 
            340                 345                 350         


Gly Cys Met Glu Asp Leu Ser Val Asn Gly Gln Arg Arg Gly Leu Arg 
        355                 360                 365             


Glu Ala Leu Leu Thr Arg Asn Met Ala Ala Gly Cys Arg Leu Glu Glu 
    370                 375                 380                 


Glu Glu Tyr Glu Asp Asp Ala Tyr Gly His Tyr Glu Ala Phe Ser Thr 
385                 390                 395                 400 


Leu Ala Pro Glu Ala Trp Pro Ala Met Glu Leu Pro Glu Pro Cys Val 
                405                 410                 415     


Pro Glu Pro Gly Leu Pro Pro Val Phe Ala Asn Phe Thr Gln Leu Leu 
            420                 425                 430         


Thr Ile Ser Pro Leu Val Val Ala Glu Gly Gly Thr Ala Trp Leu Glu 
        435                 440                 445             


Trp Arg His Val Gln Pro Thr Leu Asp Leu Met Glu Ala Glu Leu Arg 
    450                 455                 460                 


Lys Ser Gln Val Leu Phe Ser Val Thr Arg Gly Ala Arg His Gly Glu 
465                 470                 475                 480 


Leu Glu Leu Asp Ile Pro Gly Ala Gln Ala Arg Lys Met Phe Thr Leu 
                485                 490                 495     


Leu Asp Val Val Asn Arg Lys Ala Arg Phe Ile His Asp Gly Ser Glu 
            500                 505                 510         


Asp Thr Ser Asp Gln Leu Val Leu Glu Val Ser Val Thr Ala Arg Val 
        515                 520                 525             


Pro Met Pro Ser Cys Leu Arg Arg Gly Gln Thr Tyr Leu Leu Pro Ile 
    530                 535                 540                 


Gln Val Asn Pro Val Asn Asp Pro Pro His Ile Ile Phe Pro His Gly 
545                 550                 555                 560 


Ser Leu Met Val Ile Leu Glu His Thr Gln Lys Pro Leu Gly Pro Glu 
                565                 570                 575     


Val Phe Gln Ala Tyr Asp Pro Asp Ser Ala Cys Glu Gly Leu Thr Phe 
            580                 585                 590         


Gln Val Leu Gly Thr Ser Ser Gly Leu Pro Val Glu Arg Arg Asp Gln 
        595                 600                 605             


Pro Gly Glu Pro Ala Thr Glu Phe Ser Cys Arg Glu Leu Glu Ala Gly 
    610                 615                 620                 


Ser Leu Val Tyr Val His Arg Gly Gly Pro Ala Gln Asp Leu Thr Phe 
625                 630                 635                 640 


Arg Val Ser Asp Gly Leu Gln Ala Ser Pro Pro Ala Thr Leu Lys Val 
                645                 650                 655     


Val Ala Ile Arg Pro Ala Ile Gln Ile His Arg Ser Thr Gly Leu Arg 
            660                 665                 670         


Leu Ala Gln Gly Ser Ala Met Pro Ile Leu Pro Ala Asn Leu Ser Val 
        675                 680                 685             


Glu Thr Asn Ala Val Gly Gln Asp Val Ser Val Leu Phe Arg Val Thr 
    690                 695                 700                 


Gly Ala Leu Gln Phe Gly Glu Leu Gln Lys Gln Gly Ala Gly Gly Val 
705                 710                 715                 720 


Glu Gly Ala Glu Trp Trp Ala Thr Gln Ala Phe His Gln Arg Asp Val 
                725                 730                 735     


Glu Gln Gly Arg Val Arg Tyr Leu Ser Thr Asp Pro Gln His His Ala 
            740                 745                 750         


Tyr Asp Thr Val Glu Asn Leu Ala Leu Glu Val Gln Val Gly Gln Glu 
        755                 760                 765             


Ile Leu Ser Asn Leu Ser Phe Pro Val Thr Ile Gln Arg Ala Thr Val 
    770                 775                 780                 


Trp Met Leu Arg Leu Glu Pro Leu His Thr Gln Asn Thr Gln Gln Glu 
785                 790                 795                 800 


Thr Leu Thr Thr Ala His Leu Glu Ala Thr Leu Glu Glu Ala Gly Pro 
                805                 810                 815     


Ser Pro Pro Thr Phe His Tyr Glu Val Val Gln Ala Pro Arg Lys Gly 
            820                 825                 830         


Asn Leu Gln Leu Gln Gly Thr Arg Leu Ser Asp Gly Gln Gly Phe Thr 
        835                 840                 845             


Gln Asp Asp Ile Gln Ala Gly Arg Val Thr Tyr Gly Ala Thr Ala Arg 
    850                 855                 860                 


Ala Ser Glu Ala Val Glu Asp Thr Phe Arg Phe Arg Val Thr Ala Pro 
865                 870                 875                 880 


Pro Tyr Phe Ser Pro Leu Tyr Thr Phe Pro Ile His Ile Gly Gly Asp 
                885                 890                 895     


Pro Asp Ala Pro Val Leu Thr Asn Val Leu Leu Val Val Pro Glu Gly 
            900                 905                 910         


Gly Glu Gly Val Leu Ser Ala Asp His Leu Phe Val Lys Ser Leu Asn 
        915                 920                 925             


Ser Ala Ser Tyr Leu Tyr Glu Val Met Glu Arg Pro Arg His Gly Arg 
    930                 935                 940                 


Leu Ala Trp Arg Gly Thr Gln Asp Lys Thr Thr Met Val Thr Ser Phe 
945                 950                 955                 960 


Thr Asn Glu Asp Leu Leu Arg Gly Arg Leu Val Tyr Gln His Asp Asp 
                965                 970                 975     


Ser Glu Thr Thr Glu Asp Asp Ile Pro Phe Val Ala Thr Arg Gln Gly 
            980                 985                 990         


Glu Ser Ser Gly Asp Met Ala Trp  Glu Glu Val Arg Gly  Val Phe Arg 
        995                 1000                 1005             


Val Ala  Ile Gln Pro Val Asn  Asp His Ala Pro Val  Gln Thr Ile 
    1010                 1015                 1020             


Ser Arg  Ile Phe His Val Ala  Arg Gly Gly Arg Arg  Leu Leu Thr 
    1025                 1030                 1035             


Thr Asp  Asp Val Ala Phe Ser  Asp Ala Asp Ser Gly  Phe Ala Asp 
    1040                 1045                 1050             


Ala Gln  Leu Val Leu Thr Arg  Lys Asp Leu Leu Phe  Gly Ser Ile 
    1055                 1060                 1065             


Val Ala  Val Asp Glu Pro Thr  Arg Pro Ile Tyr Arg  Phe Thr Gln 
    1070                 1075                 1080             


Glu Asp  Leu Arg Lys Arg Arg  Val Leu Phe Val His  Ser Gly Ala 
    1085                 1090                 1095             


Asp Arg  Gly Trp Ile Gln Leu  Gln Val Ser Asp Gly  Gln His Gln 
    1100                 1105                 1110             


Ala Thr  Ala Leu Leu Glu Val  Gln Ala Ser Glu Pro  Tyr Leu Arg 
    1115                 1120                 1125             


Val Ala  Asn Gly Ser Ser Leu  Val Val Pro Gln Gly  Gly Gln Gly 
    1130                 1135                 1140             


Thr Ile  Asp Thr Ala Val Leu  His Leu Asp Thr Asn  Leu Asp Ile 
    1145                 1150                 1155             


Arg Ser  Gly Asp Glu Val His  Tyr His Val Thr Ala  Gly Pro Arg 
    1160                 1165                 1170             


Trp Gly  Gln Leu Val Arg Ala  Gly Gln Pro Ala Thr  Ala Phe Ser 
    1175                 1180                 1185             


Gln Gln  Asp Leu Leu Asp Gly  Ala Val Leu Tyr Ser  His Asn Gly 
    1190                 1195                 1200             


Ser Leu  Ser Pro Arg Asp Thr  Met Ala Phe Ser Val  Glu Ala Gly 
    1205                 1210                 1215             


Pro Val  His Thr Asp Ala Thr  Leu Gln Val Thr Ile  Ala Leu Glu 
    1220                 1225                 1230             


Gly Pro  Leu Ala Pro Leu Lys  Leu Val Arg His Lys  Lys Ile Tyr 
    1235                 1240                 1245             


Val Phe  Gln Gly Glu Ala Ala  Glu Ile Arg Arg Asp  Gln Leu Glu 
    1250                 1255                 1260             


Ala Ala  Gln Glu Ala Val Pro  Pro Ala Asp Ile Val  Phe Ser Val 
    1265                 1270                 1275             


Lys Ser  Pro Pro Ser Ala Gly  Tyr Leu Val Met Val  Ser Arg Gly 
    1280                 1285                 1290             


Ala Leu  Ala Asp Glu Pro Pro  Ser Leu Asp Pro Val  Gln Ser Phe 
    1295                 1300                 1305             


Ser Gln  Glu Ala Val Asp Thr  Gly Arg Val Leu Tyr  Leu His Ser 
    1310                 1315                 1320             


Arg Pro  Glu Ala Trp Ser Asp  Ala Phe Ser Leu Asp  Val Ala Ser 
    1325                 1330                 1335             


Gly Leu  Gly Ala Pro Leu Glu  Gly Val Leu Val Glu  Leu Glu Val 
    1340                 1345                 1350             


Leu Pro  Ala Ala Ile Pro Leu  Glu Ala Gln Asn Phe  Ser Val Pro 
    1355                 1360                 1365             


Glu Gly  Gly Ser Leu Thr Leu  Ala Pro Pro Leu Leu  Arg Val Ser 
    1370                 1375                 1380             


Gly Pro  Tyr Phe Pro Thr Leu  Leu Gly Leu Ser Leu  Gln Val Leu 
    1385                 1390                 1395             


Glu Pro  Pro Gln His Gly Ala  Leu Gln Lys Glu Asp  Gly Pro Gln 
    1400                 1405                 1410             


Ala Arg  Thr Leu Ser Ala Phe  Ser Trp Arg Met Val  Glu Glu Gln 
    1415                 1420                 1425             


Leu Ile  Arg Tyr Val His Asp  Gly Ser Glu Thr Leu  Thr Asp Ser 
    1430                 1435                 1440             


Phe Val  Leu Met Ala Asn Ala  Ser Glu Met Asp Arg  Gln Ser His 
    1445                 1450                 1455             


Pro Val  Ala Phe Thr Val Thr  Val Leu Pro Val Asn  Asp Gln Pro 
    1460                 1465                 1470             


Pro Ile  Leu Thr Thr Asn Thr  Gly Leu Gln Met Trp  Glu Gly Ala 
    1475                 1480                 1485             


Thr Ala  Pro Ile Pro Ala Glu  Ala Leu Arg Ser Thr  Asp Gly Asp 
    1490                 1495                 1500             


Ser Gly  Ser Glu Asp Leu Val  Tyr Thr Ile Glu Gln  Pro Ser Asn 
    1505                 1510                 1515             


Gly Arg  Val Val Leu Arg Gly  Ala Pro Gly Thr Glu  Val Arg Ser 
    1520                 1525                 1530             


Phe Thr  Gln Ala Gln Leu Asp  Gly Gly Leu Val Leu  Phe Ser His 
    1535                 1540                 1545             


Arg Gly  Thr Leu Asp Gly Gly  Phe Arg Phe Arg Leu  Ser Asp Gly 
    1550                 1555                 1560             


Glu His  Thr Ser Pro Gly His  Phe Phe Arg Val Thr  Ala Gln Lys 
    1565                 1570                 1575             


Gln Val  Leu Leu Ser Leu Lys  Gly Ser Gln Thr Leu  Thr Val Cys 
    1580                 1585                 1590             


Pro Gly  Ser Val Gln Pro Leu  Ser Ser Gln Thr Leu  Arg Ala Ser 
    1595                 1600                 1605             


Ser Ser  Ala Gly Thr Asp Pro  Gln Leu Leu Leu Tyr  Arg Val Val 
    1610                 1615                 1620             


Arg Gly  Pro Gln Leu Gly Arg  Leu Phe His Ala Gln  Gln Asp Ser 
    1625                 1630                 1635             


Thr Gly  Glu Ala Leu Val Asn  Phe Thr Gln Ala Glu  Val Tyr Ala 
    1640                 1645                 1650             


Gly Asn  Ile Leu Tyr Glu His  Glu Met Pro Pro Glu  Pro Phe Trp 
    1655                 1660                 1665             


Glu Ala  His Asp Thr Leu Glu  Leu Gln Leu Ser Ser  Pro Pro Ala 
    1670                 1675                 1680             


Arg Asp  Val Ala Ala Thr Leu  Ala Val Ala Val Ser  Phe Glu Ala 
    1685                 1690                 1695             


Ala Cys  Pro Gln Arg Pro Ser  His Leu Trp Lys Asn  Lys Gly Leu 
    1700                 1705                 1710             


Trp Val  Pro Glu Gly Gln Arg  Ala Arg Ile Thr Val  Ala Ala Leu 
    1715                 1720                 1725             


Asp Ala  Ser Asn Leu Leu Ala  Ser Val Pro Ser Pro  Gln Arg Ser 
    1730                 1735                 1740             


Glu His  Asp Val Leu Phe Gln  Val Thr Gln Phe Pro  Ser Arg Gly 
    1745                 1750                 1755             


Gln Leu  Leu Val Ser Glu Glu  Pro Leu His Ala Gly  Gln Pro His 
    1760                 1765                 1770             


Phe Leu  Gln Ser Gln Leu Ala  Ala Gly Gln Leu Val  Tyr Ala His 
    1775                 1780                 1785             


Gly Gly  Gly Gly Thr Gln Gln  Asp Gly Phe His Phe  Arg Ala His 
    1790                 1795                 1800             


Leu Gln  Gly Pro Ala Gly Ala  Ser Val Ala Gly Pro  Gln Thr Ser 
    1805                 1810                 1815             


Glu Ala  Phe Ala Ile Thr Val  Arg Asp Val Asn Glu  Arg Pro Pro 
    1820                 1825                 1830             


Gln Pro  Gln Ala Ser Val Pro  Leu Arg Leu Thr Arg  Gly Ser Arg 
    1835                 1840                 1845             


Ala Pro  Ile Ser Arg Ala Gln  Leu Ser Val Val Asp  Pro Asp Ser 
    1850                 1855                 1860             


Ala Pro  Gly Glu Ile Glu Tyr  Glu Val Gln Arg Ala  Pro His Asn 
    1865                 1870                 1875             


Gly Phe  Leu Ser Leu Val Gly  Gly Gly Leu Gly Pro  Val Thr Arg 
    1880                 1885                 1890             


Phe Thr  Gln Ala Asp Val Asp  Ser Gly Arg Leu Ala  Phe Val Ala 
    1895                 1900                 1905             


Asn Gly  Ser Ser Val Ala Gly  Ile Phe Gln Leu Ser  Met Ser Asp 
    1910                 1915                 1920             


Gly Ala  Ser Pro Pro Leu Pro  Met Ser Leu Ala Val  Asp Ile Leu 
    1925                 1930                 1935             


Pro Ser  Ala Ile Glu Val Gln  Leu Arg Ala Pro Leu  Glu Val Pro 
    1940                 1945                 1950             


Gln Ala  Leu Gly Arg Ser Ser  Leu Ser Gln Gln Gln  Leu Arg Val 
    1955                 1960                 1965             


Val Ser  Asp Arg Glu Glu Pro  Glu Ala Ala Tyr Arg  Leu Ile Gln 
    1970                 1975                 1980             


Gly Pro  Gln Tyr Gly His Leu  Leu Val Gly Gly Arg  Pro Thr Ser 
    1985                 1990                 1995             


Ala Phe  Ser Gln Phe Gln Ile  Asp Gln Gly Glu Val  Val Phe Ala 
    2000                 2005                 2010             


Phe Thr  Asn Phe Ser Ser Ser  His Asp His Phe Arg  Val Leu Ala 
    2015                 2020                 2025             


Leu Ala  Arg Gly Val Asn Ala  Ser Ala Val Val Asn  Val Thr Val 
    2030                 2035                 2040             


Arg Ala  Leu Leu His Val Trp  Ala Gly Gly Pro Trp  Pro Gln Gly 
    2045                 2050                 2055             


Ala Thr  Leu Arg Leu Asp Pro  Thr Val Leu Asp Ala  Gly Glu Leu 
    2060                 2065                 2070             


Ala Asn  Arg Thr Gly Ser Val  Pro Arg Phe Arg Leu  Leu Glu Gly 
    2075                 2080                 2085             


Pro Arg  His Gly Arg Val Val  Arg Val Pro Arg Ala  Arg Thr Glu 
    2090                 2095                 2100             


Pro Gly  Gly Ser Gln Leu Val  Glu Gln Phe Thr Gln  Gln Asp Leu 
    2105                 2110                 2115             


Glu Asp  Gly Arg Leu Gly Leu  Glu Val Gly Arg Pro  Glu Gly Arg 
    2120                 2125                 2130             


Ala Pro  Gly Pro Ala Gly Asp  Ser Leu Thr Leu Glu  Leu Trp Ala 
    2135                 2140                 2145             


Gln Gly  Val Pro Pro Ala Val  Ala Ser Leu Asp Phe  Ala Thr Glu 
    2150                 2155                 2160             


Pro Tyr  Asn Ala Ala Arg Pro  Tyr Ser Val Ala Leu  Leu Ser Val 
    2165                 2170                 2175             


Pro Glu  Ala Ala Arg Thr Glu  Ala Gly Lys Pro Glu  Ser Ser Thr 
    2180                 2185                 2190             


Pro Thr  Gly Glu Pro Gly Pro  Met Ala Ser Ser Pro  Glu Pro Ala 
    2195                 2200                 2205             


Val Ala  Lys Gly Gly Phe Leu  Ser Phe Leu Glu Ala  Asn Met Phe 
    2210                 2215                 2220             


Ser Val  Ile Ile Pro Met Cys  Leu Val Leu Leu Leu  Leu Ala Leu 
    2225                 2230                 2235             


Ile Leu  Pro Leu Leu Phe Tyr  Leu Arg Lys Arg Asn  Lys Thr Gly 
    2240                 2245                 2250             


Lys His  Asp Val Gln Val Leu  Thr Ala Lys Pro Arg  Asn Gly Leu 
    2255                 2260                 2265             


Ala Gly  Asp Thr Glu Thr Phe  Arg Lys Val Glu Pro  Gly Gln Ala 
    2270                 2275                 2280             


Ile Pro  Leu Thr Ala Val Pro  Gly Gln Gly Pro Pro  Pro Gly Gly 
    2285                 2290                 2295             


Gln Pro  Asp Pro Glu Leu Leu  Gln Phe Cys Arg Thr  Pro Asn Pro 
    2300                 2305                 2310             


Ala Leu  Lys Asn Gly Gln Tyr  Trp Val 
    2315                 2320         


<210> 2
<211> 2327
<212> PRT
<213> Mus musculus

<400> 2
Met Leu Leu Gly Pro Gly His Pro Leu Ser Ala Pro Ala Leu Ala Leu 
1               5                   10                  15      


Ala Leu Thr Leu Ala Leu Leu Val Arg Ser Thr Ala Pro Ala Ser Phe 
            20                  25                  30          


Phe Gly Glu Asn His Leu Glu Val Pro Val Pro Ser Ala Leu Thr Arg 
        35                  40                  45              


Val Asp Leu Leu Leu Gln Phe Ser Thr Ser Gln Pro Glu Ala Leu Leu 
    50                  55                  60                  


Leu Leu Ala Ala Gly Gln Asp Asp His Leu Leu Leu Gln Leu His Ser 
65                  70                  75                  80  


Gly Cys Leu Gln Val Arg Leu Ala Leu Gly Gln Lys Glu Leu Lys Leu 
                85                  90                  95      


Gln Thr Pro Ala Asp Thr Val Leu Ser Asp Ser Ala Pro His Thr Val 
            100                 105                 110         


Val Leu Thr Val Ser Asp Ser Trp Ala Val Leu Ser Val Asp Gly Val 
        115                 120                 125             


Leu Asn Thr Ser Ala Pro Ile Pro Arg Ala Ser His Leu Lys Ala Thr 
    130                 135                 140                 


Tyr Gly Leu Phe Val Gly Ser Ser Gly Ser Leu Asp Leu Pro Tyr Leu 
145                 150                 155                 160 


Lys Gly Ile Ser Arg Pro Leu Arg Gly Cys Leu His Ser Ala Ile Leu 
                165                 170                 175     


Asn Gly Arg Asn Leu Leu Arg Pro Leu Thr Ser Asp Val His Glu Gly 
            180                 185                 190         


Cys Ala Glu Glu Phe Ser Ala Gly Asp Glu Val Gly Leu Gly Phe Ser 
        195                 200                 205             


Gly Pro His Ser Leu Ala Ala Phe Pro Ala Trp Ser Thr Arg Glu Glu 
    210                 215                 220                 


Gly Thr Leu Glu Phe Thr Leu Thr Thr Arg Ser Gln Gln Ala Pro Leu 
225                 230                 235                 240 


Ala Phe Gln Ala Gly Asp Lys Arg Gly Asn Phe Ile Tyr Val Asp Ile 
                245                 250                 255     


Phe Glu Gly His Leu Arg Ala Val Val Glu Lys Gly Gln Gly Thr Met 
            260                 265                 270         


Leu Leu Arg Asn Ser Val Pro Val Ala Asp Gly Gln Pro His Glu Val 
        275                 280                 285             


Ser Val His Ile Asp Val His Arg Leu Glu Ile Ser Val Asp Gln Tyr 
    290                 295                 300                 


Pro Thr Arg Thr Phe Asn Arg Gly Val Leu Ser Tyr Leu Glu Pro Arg 
305                 310                 315                 320 


Gly Ser Leu Leu Leu Gly Gly Leu Asp Thr Glu Ala Ser Arg His Leu 
                325                 330                 335     


Gln Glu His Arg Leu Gly Leu Ala Pro Gly Ala Ala Asn Ile Ser Leu 
            340                 345                 350         


Val Gly Cys Ile Glu Asp Phe Ser Val Asn Gly Arg Arg Gln Gly Leu 
        355                 360                 365             


Arg Asp Ala Trp Leu Thr Arg Asp Met Ser Ala Gly Cys Arg Pro Glu 
    370                 375                 380                 


Glu Asp Glu Tyr Glu Glu Glu Val Tyr Gly Pro Tyr Glu Thr Phe Ser 
385                 390                 395                 400 


Thr Leu Ala Pro Glu Ala Trp Pro Ala Met Glu Leu Pro Glu Pro Cys 
                405                 410                 415     


Ile Pro Glu Pro Gly Leu Pro Ala Val Phe Ala Asn Phe Thr Gln Leu 
            420                 425                 430         


Leu Thr Ile Ser Pro Leu Val Val Ala Glu Gly Gly Thr Ala Trp Leu 
        435                 440                 445             


Glu Trp Arg His Val Gln Pro Thr Leu Asp Leu Thr Glu Ala Glu Leu 
    450                 455                 460                 


Arg Lys Ser Gln Val Leu Phe Ser Val Ser Gln Ser Ala Arg His Gly 
465                 470                 475                 480 


Asp Leu Glu Leu Asp Ile Leu Gly Ala Gln Thr Arg Lys Met Phe Thr 
                485                 490                 495     


Leu Leu Asp Val Val Asn Arg Lys Ala Arg Phe Val His Asp Gly Ser 
            500                 505                 510         


Glu Asp Thr Ser Asp Gln Leu Met Leu Glu Val Ser Val Thr Ala Arg 
        515                 520                 525             


Ala Pro Val Pro Ser Cys Leu Arg Arg Gly Gln Ile Tyr Ile Leu Pro 
    530                 535                 540                 


Ile Gln Val Asn Pro Val Asn Asp Pro Pro Arg Ile Ile Phe Pro His 
545                 550                 555                 560 


Gly Ser Leu Met Val Ile Leu Glu His Thr Gln Lys Pro Leu Gly Pro 
                565                 570                 575     


Glu Ile Phe Gln Ala Tyr Asp Pro Asp Ser Ala Cys Glu Gly Leu Thr 
            580                 585                 590         


Phe Gln Leu Leu Gly Val Ser Ser Gly Val Pro Val Glu His Arg Asp 
        595                 600                 605             


Gln Pro Gly Glu Pro Ala Thr Glu Phe Ser Cys Arg Glu Leu Glu Val 
    610                 615                 620                 


Gly Asp Ile Val Tyr Val His Arg Gly Gly Pro Ala Gln Asp Leu Thr 
625                 630                 635                 640 


Phe Arg Val Ser Asp Gly Met Gln Ala Ser Ala Pro Ala Thr Leu Lys 
                645                 650                 655     


Val Val Ala Val Arg Pro Ala Ile Gln Ile Leu His Asn Thr Gly Leu 
            660                 665                 670         


His Leu Ala Gln Gly Ser Ala Ala Ala Ile Leu Pro Ala Asn Leu Ser 
        675                 680                 685             


Val Glu Thr Asn Ala Val Gly Gln Asp Val Ser Val Leu Phe Arg Val 
    690                 695                 700                 


Thr Gly Thr Leu Gln Phe Gly Glu Leu Gln Lys Gln Gly Ala Gly Gly 
705                 710                 715                 720 


Val Glu Gly Thr Glu Trp Trp Asp Thr Leu Ala Phe His Gln Arg Asp 
                725                 730                 735     


Val Glu Gln Gly Arg Val Arg Tyr Leu Ser Thr Asp Pro Gln His His 
            740                 745                 750         


Thr Gln Asp Thr Val Glu Asp Leu Ile Leu Glu Val Gln Val Gly Gln 
        755                 760                 765             


Glu Thr Leu Ser Asn Leu Ser Phe Pro Val Thr Ile Gln Arg Ala Thr 
    770                 775                 780                 


Val Trp Met Leu Arg Leu Glu Pro Leu His Thr Gln Asn Pro His Gln 
785                 790                 795                 800 


Glu Thr Leu Thr Pro Ala His Leu Glu Ala Ser Leu Glu Glu Glu Glu 
                805                 810                 815     


Glu Glu Gly Ser Pro Gln Pro His Thr Phe His Tyr Glu Leu Val Gln 
            820                 825                 830         


Ala Pro Arg Arg Gly Asn Leu Leu Leu Gln Gly Thr Arg Leu Ser Asp 
        835                 840                 845             


Gly Glu Ser Phe Ser Gln Ser Asp Leu Gln Ala Gly Arg Val Thr Tyr 
    850                 855                 860                 


Arg Ala Thr Met Arg Thr Ser Glu Ala Ala Asp Asp Ser Phe Arg Phe 
865                 870                 875                 880 


Arg Val Thr Ser Pro Pro His Phe Ser Pro Leu Tyr Thr Phe Pro Ile 
                885                 890                 895     


His Ile Gly Gly Asp Pro Asn Ala Pro Val Leu Thr Asn Val Leu Leu 
            900                 905                 910         


Met Val Pro Glu Gly Gly Glu Gly Val Leu Ser Ala Asp His Leu Phe 
        915                 920                 925             


Val Lys Ser Leu Asn Ser Ala Ser Tyr Leu Tyr Glu Val Met Glu Gln 
    930                 935                 940                 


Pro His His Gly Lys Leu Ala Trp Arg Asp Pro Lys Gly Lys Ser Thr 
945                 950                 955                 960 


Pro Val Thr Ser Phe Thr Asn Glu Asp Leu Leu His Gly Arg Leu Val 
                965                 970                 975     


Tyr Gln His Asp Asp Ser Glu Thr Ile Glu Asp Asp Ile Pro Phe Val 
            980                 985                 990         


Ala Thr Arg Gln Gly Glu Gly Ser  Gly Asp Met Ala Trp  Glu Glu Val 
        995                 1000                 1005             


Arg Gly  Val Phe Arg Val Ala  Ile Gln Pro Val Asn  Asp His Ala 
    1010                 1015                 1020             


Pro Val  Gln Thr Ile Ser Arg  Val Phe His Val Ala  Arg Gly Gly 
    1025                 1030                 1035             


Gln Arg  Leu Leu Thr Thr Asp  Asp Val Ala Phe Ser  Asp Ala Asp 
    1040                 1045                 1050             


Ser Gly  Phe Ser Asp Ala Gln  Leu Val Leu Thr Arg  Lys Asp Leu 
    1055                 1060                 1065             


Leu Phe  Gly Ser Ile Val Ala  Met Glu Glu Pro Thr  Arg Pro Ile 
    1070                 1075                 1080             


Tyr Arg  Phe Thr Gln Glu Asp  Leu Arg Lys Lys Gln  Val Leu Phe 
    1085                 1090                 1095             


Val His  Ser Gly Ala Asp His  Gly Trp Leu Gln Leu  Gln Val Ser 
    1100                 1105                 1110             


Asp Gly  Gln His Gln Ala Thr  Ala Met Leu Glu Val  Gln Ala Ser 
    1115                 1120                 1125             


Glu Pro  Tyr Leu His Val Ala  Asn Ser Ser Ser Leu  Val Val Pro 
    1130                 1135                 1140             


Gln Gly  Gly Gln Gly Thr Ile  Asp Thr Ala Val Leu  Gln Leu Asp 
    1145                 1150                 1155             


Thr Asn  Leu Asp Ile Arg Ser  Gly Asn Glu Val His  Tyr His Val 
    1160                 1165                 1170             


Thr Ala  Gly Pro Gln Trp Gly  Gln Leu Leu Arg Asp  Gly Gln Ser 
    1175                 1180                 1185             


Val Thr  Ser Phe Ser Gln Arg  Asp Leu Leu Asp Gly  Ala Ile Leu 
    1190                 1195                 1200             


Tyr Ser  His Asn Gly Ser Leu  Ser Pro Gln Asp Thr  Leu Ala Phe 
    1205                 1210                 1215             


Ser Val  Ala Ala Gly Pro Val  His Thr Asn Thr Phe  Leu Gln Val 
    1220                 1225                 1230             


Thr Ile  Ala Leu Glu Gly Pro  Leu Ala Pro Leu Gln  Leu Val Gln 
    1235                 1240                 1245             


His Lys  Lys Ile Tyr Val Phe  Gln Gly Glu Ala Ala  Glu Ile Arg 
    1250                 1255                 1260             


Arg Asp  Gln Leu Glu Val Val  Gln Glu Ala Val Leu  Pro Ala Asp 
    1265                 1270                 1275             


Ile Met  Phe Ser Leu Arg Ser  Pro Pro Asn Ala Gly  Tyr Leu Val 
    1280                 1285                 1290             


Met Val  Ser His Gly Ala Ser  Ala Glu Glu Pro Pro  Ser Leu Asp 
    1295                 1300                 1305             


Pro Val  Gln Ser Phe Ser Gln  Glu Ala Val Asn Ser  Gly Arg Val 
    1310                 1315                 1320             


Leu Tyr  Leu His Ser Arg Pro  Gly Ala Trp Ser Asp  Ser Phe Ser 
    1325                 1330                 1335             


Leu Asp  Val Ala Ser Gly Leu  Gly Asp Pro Leu Glu  Gly Ile Ser 
    1340                 1345                 1350             


Val Glu  Leu Glu Val Leu Pro  Thr Val Ile Pro Leu  Asp Val Gln 
    1355                 1360                 1365             


Asn Phe  Ser Val Pro Glu Gly  Gly Thr Arg Thr Leu  Ala Pro Pro 
    1370                 1375                 1380             


Leu Val  Gln Ile Thr Gly Pro  Tyr Phe Pro Thr Leu  Pro Gly Leu 
    1385                 1390                 1395             


Val Leu  Gln Val Leu Glu Pro  Pro Gln His Gly Ala  Leu Gln Lys 
    1400                 1405                 1410             


Glu Asp  His Ser Gln Asp Gly  Ser Leu Ser Thr Phe  Ser Trp Arg 
    1415                 1420                 1425             


Glu Val  Glu Glu Gln Leu Ile  Arg Tyr Val His Asp  Gly Ser Glu 
    1430                 1435                 1440             


Thr Gln  Thr Asp Ala Phe Val  Leu Leu Ala Asn Ala  Ser Glu Met 
    1445                 1450                 1455             


Asp Arg  Gln Ser Gln Pro Val  Ala Phe Thr Ile Thr  Ile Leu Pro 
    1460                 1465                 1470             


Val Asn  Asp Gln Pro Pro Val  Leu Thr Thr Asn Thr  Gly Leu Gln 
    1475                 1480                 1485             


Ile Trp  Glu Gly Ala Ile Val  Pro Ile Pro Pro Glu  Ala Leu Arg 
    1490                 1495                 1500             


Gly Thr  Asp Asn Asp Ser Gly  Pro Glu Asp Leu Val  Tyr Thr Ile 
    1505                 1510                 1515             


Glu Gln  Pro Ser Asn Gly Arg  Ile Ala Leu Arg Val  Ala Pro Asp 
    1520                 1525                 1530             


Thr Glu  Val His Arg Phe Thr  Gln Ala Gln Leu Asp  Ser Gly Leu 
    1535                 1540                 1545             


Val Leu  Phe Ser His Arg Gly  Ala Leu Glu Gly Gly  Phe His Phe 
    1550                 1555                 1560             


Asp Leu  Ser Asp Gly Ala His  Thr Ser Pro Gly His  Phe Phe Arg 
    1565                 1570                 1575             


Val Val  Ala Gln Lys Gln Ala  Leu Leu Ser Leu Glu  Gly Thr Arg 
    1580                 1585                 1590             


Lys Leu  Thr Val Cys Pro Glu  Ser Val Gln Pro Leu  Ser Ser Gln 
    1595                 1600                 1605             


Ser Leu  Ser Ala Ser Ser Ser  Thr Gly Ala Asp Pro  Arg His Leu 
    1610                 1615                 1620             


Leu Tyr  Arg Val Val Arg Gly  Pro Gln Leu Gly Arg  Leu Leu His 
    1625                 1630                 1635             


Ala Gln  Gln Gly Ser Ala Glu  Glu Val Leu Val Asn  Phe Thr Gln 
    1640                 1645                 1650             


Ala Glu  Val Asn Ala Gly Asn  Ile Leu Tyr Glu His  Glu Met Ser 
    1655                 1660                 1665             


Ser Glu  Pro Phe Trp Glu Ala  His Asp Thr Ile Gly  Leu Leu Leu 
    1670                 1675                 1680             


Ser Ser  Pro Pro Ala Arg Asp  Leu Ala Ala Thr Leu  Ala Val Met 
    1685                 1690                 1695             


Val Ser  Phe Asp Ala Ala Cys  Pro Gln Arg Pro Ser  Arg Leu Trp 
    1700                 1705                 1710             


Lys Asn  Lys Gly Leu Trp Val  Pro Glu Gly Gln Arg  Ala Lys Ile 
    1715                 1720                 1725             


Thr Val  Ala Ala Leu Asp Ala  Ala Asn Leu Leu Ala  Ser Val Pro 
    1730                 1735                 1740             


Ala Ser  Gln Arg Ser Arg His  Asp Val Leu Phe Gln  Val Thr Gln 
    1745                 1750                 1755             


Phe Pro  Thr Arg Gly Gln Leu  Leu Val Ser Glu Glu  Pro Leu His 
    1760                 1765                 1770             


Ala Arg  Arg Pro Tyr Phe Leu  Gln Ser Glu Leu Ala  Ala Gly Gln 
    1775                 1780                 1785             


Leu Val  Tyr Ala His Gly Gly  Gly Gly Thr Gln Gln  Asp Gly Phe 
    1790                 1795                 1800             


Arg Phe  Arg Ala His Leu Gln  Gly Pro Thr Gly Thr  Ser Val Ala 
    1805                 1810                 1815             


Gly Pro  Gln Thr Ser Glu Ala  Phe Val Ile Thr Val  Arg Asp Val 
    1820                 1825                 1830             


Asn Glu  Arg Pro Pro Gln Pro  Gln Ala Ser Ile Pro  Leu Arg Val 
    1835                 1840                 1845             


Thr Arg  Gly Ser Arg Ala Pro  Val Ser Arg Ala Gln  Leu Ser Val 
    1850                 1855                 1860             


Val Asp  Pro Asp Ser Ala Pro  Gly Glu Ile Glu Tyr  Glu Val Gln 
    1865                 1870                 1875             


Arg Ala  Pro His Asn Gly Phe  Leu Ser Leu Ala Gly  Asp Asn Thr 
    1880                 1885                 1890             


Gly Pro  Val Thr His Phe Thr  Gln Ala Asp Val Asp  Ala Gly Arg 
    1895                 1900                 1905             


Leu Ala  Phe Val Ala Asn Gly  Ser Ser Val Ala Gly  Val Phe Gln 
    1910                 1915                 1920             


Leu Ser  Met Ser Asp Gly Ala  Ser Pro Pro Ile Pro  Met Ser Leu 
    1925                 1930                 1935             


Ala Val  Asp Val Leu Pro Ser  Thr Ile Glu Val Gln  Leu Arg Ala 
    1940                 1945                 1950             


Pro Leu  Glu Val Pro Gln Ala  Leu Gly Arg Thr Ser  Leu Ser Arg 
    1955                 1960                 1965             


Gln Gln  Leu Gln Val Ile Ser  Asp Arg Glu Glu Pro  Asp Val Ala 
    1970                 1975                 1980             


Tyr Arg  Leu Thr Gln Gly Pro  Leu Tyr Gly Gln Leu  Leu Val Gly 
    1985                 1990                 1995             


Gly Gln  Pro Ala Ser Ala Phe  Ser Gln Leu Gln Val  Asp Gln Gly 
    2000                 2005                 2010             


Asp Val  Val Phe Val Phe Thr  Asn Phe Ser Ser Ser  Gln Asp His 
    2015                 2020                 2025             


Phe Lys  Val Val Ala Leu Ala  Arg Gly Val Asn Ala  Ser Ala Thr 
    2030                 2035                 2040             


Val Asn  Val Thr Val Gln Ala  Leu Leu His Val Trp  Ala Gly Gly 
    2045                 2050                 2055             


Pro Trp  Pro Gln Gly Thr Thr  Leu Arg Leu Asp Pro  Thr Val Leu 
    2060                 2065                 2070             


Asp Ala  Ser Glu Leu Ala Asn  Arg Thr Gly Ser Met  Pro His Phe 
    2075                 2080                 2085             


Arg Leu  Leu Ala Gly Pro Arg  Tyr Gly Arg Val Val  Arg Val Ser 
    2090                 2095                 2100             


Gln Gly  Arg Thr Glu Ser Arg  Ser Asn Gln Leu Val  Glu His Phe 
    2105                 2110                 2115             


Thr Gln  Arg Asp Leu Glu Glu  Gly Gln Leu Gly Leu  Glu Val Gly 
    2120                 2125                 2130             


Lys Pro  Glu Gly Arg Ser Thr  Gly Pro Ala Gly Asp  Arg Leu Thr 
    2135                 2140                 2145             


Leu Glu  Leu Trp Ala Lys Gly  Val Pro Pro Ala Val  Ala Leu Leu 
    2150                 2155                 2160             


Asp Phe  Ala Thr Glu Pro Tyr  His Ala Ala Lys Ser  Tyr Ser Val 
    2165                 2170                 2175             


Ala Leu  Leu Ser Val Pro Glu  Ala Val Arg Thr Glu  Thr Glu Lys 
    2180                 2185                 2190             


Pro Gly  Arg Ser Val Pro Thr  Gly Gln Pro Gly Gln  Ala Ala Ser 
    2195                 2200                 2205             


Ser Pro  Val Pro Thr Ala Ala  Lys Gly Gly Phe Leu  Gly Phe Leu 
    2210                 2215                 2220             


Glu Ala  Asn Met Phe Ser Ile  Ile Ile Pro Val Cys  Leu Ile Leu 
    2225                 2230                 2235             


Leu Leu  Leu Ala Leu Ile Leu  Pro Leu Leu Phe Tyr  Leu Arg Lys 
    2240                 2245                 2250             


Arg Asn  Lys Thr Gly Lys His  Asp Val Gln Val Leu  Thr Ala Lys 
    2255                 2260                 2265             


Pro Arg  Asn Gly Leu Ala Gly  Asp Thr Glu Thr Phe  Arg Lys Val 
    2270                 2275                 2280             


Glu Pro  Gly Gln Ala Ile Pro  Leu Ile Thr Val Pro  Gly Gln Gly 
    2285                 2290                 2295             


Pro Pro  Pro Gly Gly Gln Pro  Asp Pro Glu Leu Leu  Gln Phe Cys 
    2300                 2305                 2310             


Arg Thr  Pro Asn Pro Ala Leu  Arg Asn Gly Gln Tyr  Trp Val 
    2315                 2320                 2325         


<210> 3
<211> 1329
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctggtta taccttcaca gactattcaa tgcactgggt gaagaagact      120

ccaggaaagg gtttaaagtg gctgggctgg ataaacactg cgactggtga gccaacatat      180

gcagatgact tcaagggacg gtttgccatc tctttggaaa cctctgccag gactgtctat      240

ttgcagatca ataatctcag aaatgaggac acggctacat atttctgttt tagttactac      300

gactactggg gccaaggcac cactctcaca gtttccgcct ccaccaaggg cccatcggtc      360

ttccccctgg caccctcctc caagagcacc tctgggggca cagcggccct gggctgcctg      420

gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc cctgaccagc      480

ggcgtgcaca ccttcccggc cgtcctacag tcctcaggac tctactccct cagcagcgtg      540

gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag      600

cccagcaaca ccaaggtgga caagagagtt gagcccaaat cttgtgacaa aactcacaca      660

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca      720

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      780

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat      840

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc      900

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac      960

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1020

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1080

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1140

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1200

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1260

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1320

ggtaaatga                                                             1329


<210> 4
<211> 442
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Met His Trp Val Lys Lys Thr Pro Gly Lys Gly Leu Lys Trp Leu 
        35                  40                  45              


Gly Trp Ile Asn Thr Ala Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Leu Glu Thr Ser Ala Arg Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Arg Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Phe Ser Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
        115                 120                 125             


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
            180                 185                 190         


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
        195                 200                 205             


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
            340                 345                 350         


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440         


<210> 5
<211> 645
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
gacatcaagc tgtcccagtc cccctccatc ctgtccgtga cccccggcga gaccgtgtcc       60

ctgtcctgcc gggcctccca gaccatctac aagaacctgc actggtacca gcagaagtcc      120

caccggtccc cccggctgct gatcaagtac ggctccgact ccatctccgg catcccctcc      180

cggttcaccg gctccggctc cggcaccgac tacaccctga acatcaactc cgtgaagccc      240

gaggacgagg gcatctacta ctgcctgcag ggctactcca ccccctggac cttcggcggc      300

ggcaccaagc tggagatcaa gcggaccgtg gccgccccct ccgtgttcat cttccccccc      360

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa caacttctac      420

ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      480

gagtccgtga ccgagcagga ctccaaggac tccacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgtcctccc ccgtgaccaa gtccttcaac cggggcgagt gctag                      645


<210> 6
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Asp Ile Lys Leu Ser Gln Ser Pro Ser Ile Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Thr Val Ser Leu Ser Cys Arg Ala Ser Gln Thr Ile Tyr Lys Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Arg Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Gly Ser Asp Ser Ile Ser Gly Ile Pro Ser Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Asn Ile Asn Ser Val Lys Pro 
65                  70                  75                  80  


Glu Asp Glu Gly Ile Tyr Tyr Cys Leu Gln Gly Tyr Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 7
<211> 1332
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
cagatccagc tggtgcagtc cggccccgag gtgaagaagc ccggcgcctc cgtgaagatc       60

tcctgcaagg cctccggcta caccttcacc gactactcca tgcactgggt gaagaaggcc      120

cccggccagg gcctggagtg gctgggctgg atcaacaccg ccaccggcga gcccacctac      180

gccgacgact tcaagggccg gttcaccatc accctggaca cctccgcccg gaccgtgtac      240

ctgcagatca acaacctgcg gtccgaggac accgccacct acttctgctt ctcctactac      300

gactactggg gccagggcac cctgctgacc gtgtcctccg cctccaccaa gggcccatcg      360

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc      420

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc      480

agcggcgtgc acaccttccc ggccgtccta cagtcctcag gactctactc cctcagcagc      540

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac      600

aagcccagca acaccaaggt ggacaagaga gttgagccca aatcttgtga caaaactcac      660

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc      720

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      780

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      840

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc      900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      960

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1020

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1200

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1320

ccgggtaaat ga                                                         1332


<210> 8
<211> 443
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Met His Trp Val Lys Lys Ala Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Trp Ile Asn Thr Ala Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Leu Asp Thr Ser Ala Arg Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Arg Ser Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Phe Ser Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             


<210> 9
<211> 1332
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 9
caggtgcagc tggtgcagtc cggccccgag gtgaagaagc ccggcgcctc cgtgaagatc       60

tcctgcaagg cctccggcta caccttcacc gactactcca tgcactgggt gaagaaggcc      120

cccggccagg gcctgaagtg gctgggctgg atcaacaccg ccaccggcga gcccacctac      180

gccgacgact tcaagggccg gttcaccatc accctggaca cctccgcccg gaccgtgtac      240

ctggagatct cctccctgcg gtccgaggac accgccacct acttctgctt ctcctactac      300

gactactggg gccagggcac cctgctgacc gtgtcctccg cctccaccaa gggcccatcg      360

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc      420

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc      480

agcggcgtgc acaccttccc ggccgtccta cagtcctcag gactctactc cctcagcagc      540

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac      600

aagcccagca acaccaaggt ggacaagaga gttgagccca aatcttgtga caaaactcac      660

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc      720

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      780

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      840

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc      900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      960

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1020

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1200

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1320

ccgggtaaat ga                                                         1332


<210> 10
<211> 443
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Met His Trp Val Lys Lys Ala Pro Gly Gln Gly Leu Lys Trp Leu 
        35                  40                  45              


Gly Trp Ile Asn Thr Ala Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Leu Asp Thr Ser Ala Arg Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Ile Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Phe Ser Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             


<210> 11
<211> 645
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 11
gagatcaagc tgacccagtc cccctccatc ctgtccgtgt cccccggcga gaccgtgacc       60

ctgtcctgcc gggcctccca gaccatctac aagaacctgc actggtacca gcagaagtcc      120

caccggtccc cccggctgct gatcaagtac ggctccgact ccatctccgg catccccgcc      180

cggttctccg gctccggctc cggcaccgac tacaccctga ccatcaactc cgtgaagccc      240

gaggacgagg gcatctacta ctgcctgcag ggctactcca ccccctggac cttcggccag      300

ggcaccaagc tggagatcaa gcggaccgtg gccgccccct ccgtgttcat cttccccccc      360

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa caacttctac      420

ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      480

gagtccgtga ccgagcagga ctccaaggac tccacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgtcctccc ccgtgaccaa gtccttcaac cggggcgagt gctag                      645


<210> 12
<211> 240
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Glu Ile Lys Leu Thr Gln Ser Pro Ser Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Thr Val Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Tyr Lys Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Arg Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Gly Ser Asp Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Asn Ser Val Lys Pro 
65                  70                  75                  80  


Glu Asp Glu Gly Ile Tyr Tyr Cys Leu Gln Gly Tyr Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Pro Gly Val Arg Asp Arg Ala 
            180                 185                 190         


Gly Leu Gln Gly Leu His Leu Leu Pro Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210> 13
<211> 645
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 13
gagatcgtgc tgacccagtc ccccgccacc ctgtccgtgt cccccggcga gaccgtgacc       60

ctgtcctgcc gggcctccca gaccatctac aagaacctgc actggtacca gcagaagtcc      120

ggcctgtccc cccggctgct gatcaagtac ggctccgact ccatctccgg catccccgcc      180

cggttctccg gctccggctc cggcaccgac tacaccctga ccatcaactc cgtggagccc      240

gaggacgagg gcatctacta ctgcctgcag ggctactcca ccccctggac cttcggccag      300

ggcaccaagc tggagatcaa gcggaccgtg gccgccccct ccgtgttcat cttccccccc      360

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa caacttctac      420

ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      480

gagtccgtga ccgagcagga ctccaaggac tccacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgtcctccc ccgtgaccaa gtccttcaac cggggcgagt gctag                      645


<210> 14
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Thr Val Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Tyr Lys Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser Gly Leu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Gly Ser Asp Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Asn Ser Val Glu Pro 
65                  70                  75                  80  


Glu Asp Glu Gly Ile Tyr Tyr Cys Leu Gln Gly Tyr Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 15
<211> 1320
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
cagatccagc tggtgcagtc cggccccgag gtgaagaagc ccggcgcctc cgtgaagatc       60

tcctgcaagg cctccggcta caccttcacc gactactcca tgcactgggt gaagaaggcc      120

cccggccagg gcctggagtg gctgggctgg atcaacaccg ccaccggcga gcccacctac      180

gccgacgact tcaagggccg gttcaccatc accctggaca cctccgcccg gaccgtgtac      240

ctgcagatca acaacctgcg gtccgaggac accgccacct acttctgctt ctcctactac      300

gactactggg gccagggcac cctgctgacc gtgtcctccg cctccaccaa gggcccctcc      360

gtgttccccc tggccccctg ctcccggtcc acctccgagt ccaccgccgc cctgggctgc      420

ctggtgaagg actacttccc cgagcccgtg accgtgtcct ggaactccgg cgccctgacc      480

tccggcgtgc acaccttccc cgccgtgctg cagtcctccg gcctgtactc cctgtcctcc      540

gtggtgaccg tgccctcctc ctccctgggc accaagacct acacctgcaa cgtggaccac      600

aagccctcca acaccaaggt ggacaagcgg gtggagtcca agtacggccc cccctgcccc      660

tcctgccccg cccccgagtt cctgggcggc ccctccgtgt tcctgttccc ccccaagccc      720

aaggacaccc tgatgatctc ccggaccccc gaggtgacct gcgtggtggt ggacgtgtcc      780

caggaggacc ccgaggtgca gttcaactgg tacgtggacg gcgtggaggt gcacaacgcc      840

aagaccaagc cccgggagga gcagttcaac tccacctacc gggtggtgtc cgtgctgacc      900

gtgctgcacc aggactggct gaacggcaag gagtacaagt gcaaggtgtc caacaagggc      960

ctgccctcct ccatcgagaa gaccatctcc aaggccaagg gccagccccg ggagccccag     1020

gtgtacaccc tgcccccctc ccaggaggag atgaccaaga accaggtgtc cctgacctgc     1080

ctggtgaagg gcttctaccc ctccgacatc gccgtggagt gggagtccaa cggccagccc     1140

gagaacaact acaagaccac cccccccgtg ctggactccg acggctcctt cttcctgtac     1200

tcccggctga ccgtggacaa gtcccggtgg caggagggca acgtgttctc ctgctccgtg     1260

atgcacgagg ccctgcacaa ccactacacc cagaagtccc tgtccctgtc cctgggcaag     1320


<210> 16
<211> 440
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Met His Trp Val Lys Lys Ala Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Trp Ile Asn Thr Ala Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Leu Asp Thr Ser Ala Arg Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Arg Ser Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Phe Ser Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala 
    210                 215                 220                 


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
            260                 265                 270         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
305                 310                 315                 320 


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
            340                 345                 350         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
                405                 410                 415     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440 


<210> 17
<211> 1320
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 17
caggtgcagc tggtgcagtc cggccccgag gtgaagaagc ccggcgcctc cgtgaagatc       60

tcctgcaagg cctccggcta caccttcacc gactactcca tgcactgggt gaagaaggcc      120

cccggccagg gcctgaagtg gctgggctgg atcaacaccg ccaccggcga gcccacctac      180

gccgacgact tcaagggccg gttcaccatc accctggaca cctccgcccg gaccgtgtac      240

ctggagatct cctccctgcg gtccgaggac accgccacct acttctgctt ctcctactac      300

gactactggg gccagggcac cctgctgacc gtgtcctccg cctccaccaa gggcccctcc      360

gtgttccccc tggccccctg ctcccggtcc acctccgagt ccaccgccgc cctgggctgc      420

ctggtgaagg actacttccc cgagcccgtg accgtgtcct ggaactccgg cgccctgacc      480

tccggcgtgc acaccttccc cgccgtgctg cagtcctccg gcctgtactc cctgtcctcc      540

gtggtgaccg tgccctcctc ctccctgggc accaagacct acacctgcaa cgtggaccac      600

aagccctcca acaccaaggt ggacaagcgg gtggagtcca agtacggccc cccctgcccc      660

tcctgccccg cccccgagtt cctgggcggc ccctccgtgt tcctgttccc ccccaagccc      720

aaggacaccc tgatgatctc ccggaccccc gaggtgacct gcgtggtggt ggacgtgtcc      780

caggaggacc ccgaggtgca gttcaactgg tacgtggacg gcgtggaggt gcacaacgcc      840

aagaccaagc cccgggagga gcagttcaac tccacctacc gggtggtgtc cgtgctgacc      900

gtgctgcacc aggactggct gaacggcaag gagtacaagt gcaaggtgtc caacaagggc      960

ctgccctcct ccatcgagaa gaccatctcc aaggccaagg gccagccccg ggagccccag     1020

gtgtacaccc tgcccccctc ccaggaggag atgaccaaga accaggtgtc cctgacctgc     1080

ctggtgaagg gcttctaccc ctccgacatc gccgtggagt gggagtccaa cggccagccc     1140

gagaacaact acaagaccac cccccccgtg ctggactccg acggctcctt cttcctgtac     1200

tcccggctga ccgtggacaa gtcccggtgg caggagggca acgtgttctc ctgctccgtg     1260

atgcacgagg ccctgcacaa ccactacacc cagaagtccc tgtccctgtc cctgggcaag     1320


<210> 18
<211> 440
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Met His Trp Val Lys Lys Ala Pro Gly Gln Gly Leu Lys Trp Leu 
        35                  40                  45              


Gly Trp Ile Asn Thr Ala Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Leu Asp Thr Ser Ala Arg Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Ile Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Phe Ser Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala 
    210                 215                 220                 


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
            260                 265                 270         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
305                 310                 315                 320 


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
            340                 345                 350         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
                405                 410                 415     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440 


<210> 19
<211> 2129
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 19
caggtgcagc tggtgcagtc cggccccgag gtgaagaagc ccggcgcctc cgtgaagatc       60

tcctgcaagg cctccggcta caccttcacc gactactcca tgcactgggt gaagaaggcc      120

cccggccagg gcctgaagtg gctgggctgg atcaacaccg ccaccggcga gcccacctac      180

gccgacgact tcaagggccg gttcaccatc accctggaca cctccgcccg gaccgtgtac      240

ctggagatct cctccctgcg gtccgaggac accgccacct acttctgctt ctcctactac      300

gactactggg gccagggcac cctgctgacc gtgtcctccg cctccaccaa gggcccatcg      360

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc      420

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc      480

agcggcgtgc acaccttccc ggccgtccta cagtcctcag gactctactc cctcagcagc      540

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac      600

aagcccagca acaccaaggt ggacaagaga gttgagccca aatcttgtga caaaactcac      660

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc      720

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      780

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      840

cataatgcca agacaaagcc gcgggaggag cagtacgcca gcacgtaccg tgtggtcagc      900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      960

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1020

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1200

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1320

ccgggtaaag gatccggagg aggaggtagc ggaggaggag gttctggcgg agggggttcc     1380

caggtgcagc tggtgcagag cggaggagga gtggtgcagc caggaaggag cctgcgactg     1440

tcttgcaagg ctagtggcta caccttcaca cgatatacta tgcactgggt gaggcaggca     1500

cctggtaaag gcctggagtg gatcggctac attaacccct ctaggggata caccaactat     1560

aatcagaagt tcaaagacag gttcaccatc tcacgcgata actccaagaa taccgccttc     1620

ctgcagatgg actccctgcg gcccgaagat acaggcgtgt atttttgcgc tagatactat     1680

gacgatcatt actgtctgga ctattgggga caggggaccc ctgtgacagt gtccagcggt     1740

ggaggagggt caggtggagg agggagcggt ggcggagggt ctgacatcca gatgacccag     1800

tccccatcta gtctgagcgc ctctgtgggc gatagagtga ctattacctg cagtgcttca     1860

tccagcgtga gctacatgaa ctggtatcag cagacacccg gaaaggcacc taaacgctgg     1920

atctacgata ctagcaagct ggcctctggc gtgcccagtc gattcagtgg ttcaggctcc     1980

ggaaccgact ataccttcac catctctagt ctgcagcctg aggatattgc cacatactat     2040

tgtcagcagt ggtcatccaa tccattcact tttgggcagg gtaccaaact gcagattaca     2100

aggtagggat ccgagctcgg tacaaaccg                                       2129


<210> 20
<211> 701
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Met His Trp Val Lys Lys Ala Pro Gly Gln Gly Leu Lys Trp Leu 
        35                  40                  45              


Gly Trp Ile Asn Thr Ala Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Leu Asp Thr Ser Ala Arg Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Ile Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Phe Ser Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Ser Gly Gly Gly 
        435                 440                 445             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
    450                 455                 460                 


Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu 
465                 470                 475                 480 


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp 
                485                 490                 495     


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Asn 
            500                 505                 510         


Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe 
        515                 520                 525             


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Phe Leu Gln Met Asp 
    530                 535                 540                 


Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Tyr Tyr 
545                 550                 555                 560 


Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Pro Val Thr 
                565                 570                 575     


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            580                 585                 590         


Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
        595                 600                 605             


Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser 
    610                 615                 620                 


Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp 
625                 630                 635                 640 


Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
                645                 650                 655     


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln 
            660                 665                 670         


Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro 
        675                 680                 685             


Phe Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Arg 
    690                 695                 700     


<210> 21
<211> 1465
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 21
gagatcgtgc tgacccagtc ccccgccacc ctgtccgtgt cccccggcga gaccgtgacc       60

ctgtcctgcc gggcctccca gaccatctac aagaacctgc actggtacca gcagaagtcc      120

ggcctgtccc cccggctgct gatcaagtac ggctccgact ccatctccgg catccccgcc      180

cggttctccg gctccggctc cggcaccgac tacaccctga ccatcaactc cgtggagccc      240

gaggacgagg gcatctacta ctgcctgcag ggctactcca ccccctggac cttcggccag      300

ggcaccaagc tggagatcaa gcggaccgtg gccgccccct ccgtgttcat cttccccccc      360

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa caacttctac      420

ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      480

gagtccgtga ccgagcagga ctccaaggac tccacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgtcctccc ccgtgaccaa gtccttcaac cggggcgagt gcactagtgg aggaggaggt      660

agcggaggag gaggttctgg cggagggggt tcccaggtgc agctggtgca gagcggagga      720

ggagtggtgc agccaggaag gagcctgcga ctgtcttgca aggctagtgg ctacaccttc      780

acacgatata ctatgcactg ggtgaggcag gcacctggta aaggcctgga gtggatcggc      840

tacattaacc cctctagggg atacaccaac tataatcaga agttcaaaga caggttcacc      900

atctcacgcg ataactccaa gaataccgcc ttcctgcaga tggactccct gcggcccgaa      960

gatacaggcg tgtatttttg cgctagatac tatgacgatc attactgtct ggactattgg     1020

ggacagggga cccctgtgac agtgtccagc ggtggaggag ggtcaggtgg aggagggagc     1080

ggtggcggag ggtctgacat ccagatgacc cagtccccat ctagtctgag cgcctctgtg     1140

ggcgatagag tgactattac ctgcagtgct tcatccagcg tgagctacat gaactggtat     1200

cagcagacac ccggaaaggc acctaaacgc tggatctacg atactagcaa gctggcctct     1260

ggcgtgccca gtcgattcag tggttcaggc tccggaaccg actatacctt caccatctct     1320

agtctgcagc ctgaggatat tgccacatac tattgtcagc agtggtcatc caatccattc     1380

acttttgggc agggtaccaa actgcagatt acaaggtagt ctagagcttg cctcgagcag     1440

cgctgctcga gagatctacg ggtgg                                           1465


<210> 22
<211> 472
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Thr Val Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Tyr Lys Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser Gly Leu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Gly Ser Asp Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Asn Ser Val Glu Pro 
65                  70                  75                  80  


Glu Asp Glu Gly Ile Tyr Tyr Cys Leu Gln Gly Tyr Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly 
225                 230                 235                 240 


Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser 
                245                 250                 255     


Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro 
            260                 265                 270         


Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr 
        275                 280                 285             


Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Arg Asp 
    290                 295                 300                 


Asn Ser Lys Asn Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu 
305                 310                 315                 320 


Asp Thr Gly Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys 
                325                 330                 335     


Leu Asp Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly 
            340                 345                 350         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
        355                 360                 365             


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
    370                 375                 380                 


Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
385                 390                 395                 400 


Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser 
                405                 410                 415     


Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
            420                 425                 430         


Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
        435                 440                 445             


Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Gln 
    450                 455                 460                 


Gly Thr Lys Leu Gln Ile Thr Arg 
465                 470         


<210> 23
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


