                         SEQUENCE LISTING

<110>  Synageva BioPharma Corp.
 
<120>  THERAPEUTIC COMPOSITIONS OF ALPHA-L-IDURONIDASE, 
       IDURONATE-2-SULFATASE, AND alpha-GALACTOSIDASE A AND 	   	  METHODS OF USE THEREOF 

<130>  121424-03720

<140>	  New Application
<141>  Concurrently herewith

<150>  62/077,654
<151>  2014-11-10

<150>  62/080,838
<151>  2014-11-17

<150>  62/093,316
<151>  2014-12-17

<150>  62/173,091
<151>  2015-06-09

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  4
<212>  PRT
<213>  Synthetic

<400>  1

Lys Lys Lys Lys 
1               


<210>  2
<211>  8
<212>  PRT
<213>  Synthetic

<400>  2

Lys Lys Lys Lys Lys Lys Lys Lys 
1               5               


<210>  3
<211>  12
<212>  PRT
<213>  Synthetic

<400>  3

Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys 
1               5                   10          


<210>  4
<211>  16
<212>  PRT
<213>  Synthetic

<400>  4

Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys 
1               5                   10                  15      


<210>  5
<211>  4
<212>  PRT
<213>  Synthetic

<400>  5

Arg Arg Arg Arg 
1               


<210>  6
<211>  8
<212>  PRT
<213>  Synthetic

<400>  6

Arg Arg Arg Arg Arg Arg Arg Arg 
1               5               


<210>  7
<211>  12
<212>  PRT
<213>  Synthetic

<400>  7

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10          


<210>  8
<211>  16
<212>  PRT
<213>  Synthetic

<400>  8

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15      


<210>  9
<211>  4
<212>  PRT
<213>  Synthetic

<400>  9

Lys Arg Lys Arg 
1               


<210>  10
<211>  4
<212>  PRT
<213>  Synthetic

<400>  10

Lys Lys Lys Arg 
1               


<210>  11
<211>  12
<212>  PRT
<213>  Synthetic

<400>  11

Lys Lys Lys Arg Arg Arg Lys Lys Lys Arg Arg Arg 
1               5                   10          


<210>  12
<211>  16
<212>  PRT
<213>  Synthetic

<400>  12

Lys Lys Lys Lys Arg Arg Arg Arg Lys Lys Lys Lys Arg Arg Arg Arg 
1               5                   10                  15      


<210>  13
<211>  20
<212>  PRT
<213>  Synthetic

<400>  13

Leu Arg Val Arg Leu Ala Ser His Leu Arg Lys Leu Arg Lys Arg Leu 
1               5                   10                  15      


Leu Arg Asp Ala 
            20  


<210>  14
<211>  23
<212>  PRT
<213>  Synthetic

<400>  14

Ser Ser Val Ile Asp Ala Leu Gln Tyr Lys Leu Glu Gly Thr Thr Arg 
1               5                   10                  15      


Leu Thr Arg Lys Arg Gly Leu 
            20              


<210>  15
<211>  17
<212>  PRT
<213>  Synthetic

<400>  15

Lys Leu Ala Thr Ala Leu Ser Leu Ser Asn Lys Phe Val Glu Gly Ser 
1               5                   10                  15      


His 
    


<210>  16
<211>  23
<212>  PRT
<213>  Synthetic

<400>  16

Tyr Pro Ala Lys Pro Glu Ala Pro Gly Glu Asp Ala Ser Pro Glu Glu 
1               5                   10                  15      


Leu Ser Arg Tyr Tyr Ala Ser 
            20              


<210>  17
<211>  13
<212>  PRT
<213>  Synthetic

<400>  17

Leu Arg His Tyr Leu Asn Leu Val Thr Arg Gln Arg Tyr 
1               5                   10              


<210>  18
<211>  23
<212>  PRT
<213>  Synthetic

<400>  18

Ala Lys Pro Glu Ala Pro Gly Glu Asp Ala Ser Pro Glu Glu Leu Ser 
1               5                   10                  15      


Arg Tyr Tyr Ala Ser Leu Arg 
            20              


<210>  19
<211>  11
<212>  PRT
<213>  Synthetic

<400>  19

His Tyr Leu Asn Leu Val Thr Arg Gln Arg Tyr 
1               5                   10      


<210>  20
<211>  23
<212>  PRT
<213>  Synthetic

<400>  20

Tyr Pro Ser Asp Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu Asp 
1               5                   10                  15      


Leu Ala Arg Tyr Tyr Ser Ala 
            20              


<210>  21
<211>  13
<212>  PRT
<213>  Synthetic

<400>  21

Leu Arg His Tyr Ile Asn Leu Ile Thr Arg Gln Arg Tyr 
1               5                   10              


<210>  22
<211>  23
<212>  PRT
<213>  Synthetic

<400>  22

Ala Pro Leu Glu Pro Val Tyr Pro Gly Asp Asp Ala Thr Pro Glu Gln 
1               5                   10                  15      


Met Ala Gln Tyr Ala Ala Glu 
            20              


<210>  23
<211>  13
<212>  PRT
<213>  Synthetic

<400>  23

Leu Arg Arg Tyr Ile Asn Met Leu Thr Arg Pro Arg Tyr 
1               5                   10              


<210>  24
<211>  20
<212>  PRT
<213>  Synthetic

<400>  24

Leu Arg Ser Arg Leu Ala Ser His Leu Arg Lys Leu Arg Lys Arg Leu 
1               5                   10                  15      


Leu Arg Asp Ala 
            20  


<210>  25
<211>  20
<212>  PRT
<213>  Synthetic

<400>  25

Leu Arg Val Arg Met Ala Ser His Leu Arg Lys Leu Arg Lys Arg Leu 
1               5                   10                  15      


Leu Arg Asp Ala 
            20  


<210>  26
<211>  20
<212>  PRT
<213>  Synthetic

<400>  26

Leu Arg Val Arg Leu Ala Thr His Leu Arg Lys Leu Arg Lys Arg Leu 
1               5                   10                  15      


Leu Arg Asp Ala 
            20  


<210>  27
<211>  20
<212>  PRT
<213>  Synthetic

<400>  27

Leu Arg Val Arg Leu Ala Ser His Leu Arg Lys Leu Pro Lys Arg Leu 
1               5                   10                  15      


Leu Arg Asp Ala 
            20  


<210>  28
<211>  20
<212>  PRT
<213>  Synthetic

<400>  28

Leu Arg Val Arg Leu Ala Ser His Leu Arg Lys Leu Arg Lys Arg Leu 
1               5                   10                  15      


Met Arg Asp Ala 
            20  


<210>  29
<211>  20
<212>  PRT
<213>  Synthetic

<400>  29

Leu Arg Val Arg Leu Ala Ser His Leu Arg Asn Leu Arg Lys Arg Leu 
1               5                   10                  15      


Leu Arg Asp Ala 
            20  


<210>  30
<211>  20
<212>  PRT
<213>  Synthetic

<400>  30

Leu Arg Val Arg Leu Ala Ser His Leu Arg Lys Val Arg Lys Arg Leu 
1               5                   10                  15      


Leu Arg Asp Ala 
            20  


<210>  31
<211>  20
<212>  PRT
<213>  Synthetic

<400>  31

Leu Arg Val Arg Met Ser Ser His Leu Arg Lys Leu Arg Lys Arg Leu 
1               5                   10                  15      


Leu Arg Asp Ala 
            20  


<210>  32
<211>  20
<212>  PRT
<213>  Synthetic

<400>  32

Leu Arg Val Arg Leu Ala Ser His Leu Arg Asn Val Arg Lys Arg Leu 
1               5                   10                  15      


Leu Arg Asp Ala 
            20  


<210>  33
<211>  20
<212>  PRT
<213>  Synthetic

<400>  33

Leu Arg Val Arg Leu Ala Ser His Leu Arg Asn Met Arg Lys Arg Leu 
1               5                   10                  15      


Leu Arg Asp Ala 
            20  


<210>  34
<211>  20
<212>  PRT
<213>  Synthetic

<400>  34

Leu Arg Ala Arg Met Ala Ser His Leu Arg Lys Leu Arg Lys Arg Leu 
1               5                   10                  15      


Leu Arg Asp Ala 
            20  


<210>  35
<211>  20
<212>  PRT
<213>  Synthetic

<400>  35

Leu Arg Val Arg Leu Ser Ser His Leu Arg Lys Leu Arg Lys Arg Leu 
1               5                   10                  15      


Met Arg Asp Ala 
            20  


<210>  36
<211>  20
<212>  PRT
<213>  Synthetic

<400>  36

Leu Arg Ser Arg Leu Ala Ser His Leu Arg Lys Leu Arg Lys Arg Leu 
1               5                   10                  15      


Met Arg Asp Ala 
            20  


<210>  37
<211>  20
<212>  PRT
<213>  Synthetic

<400>  37

Leu Arg Val Arg Leu Ser Ser His Leu Pro Lys Leu Arg Lys Arg Leu 
1               5                   10                  15      


Leu Arg Asp Ala 
            20  


<210>  38
<211>  20
<212>  PRT
<213>  Synthetic

<400>  38

Leu Arg Val Arg Leu Ala Ser His Leu Arg Lys Met Arg Lys Arg Leu 
1               5                   10                  15      


Met Arg Asp Ala 
            20  


<210>  39
<211>  20
<212>  PRT
<213>  Synthetic

<400>  39

Leu Arg Val Arg Leu Ala Ser His Leu Arg Asn Leu Pro Lys Arg Leu 
1               5                   10                  15      


Leu Arg Asp Ala 
            20  


<210>  40
<211>  20
<212>  PRT
<213>  Synthetic

<400>  40

Leu Arg Leu Arg Leu Ala Ser His Leu Arg Lys Leu Arg Lys Arg Leu 
1               5                   10                  15      


Leu Arg Asp Leu 
            20  


<210>  41
<211>  20
<212>  PRT
<213>  Synthetic

<400>  41

Leu Arg Val Arg Leu Ala Asn His Leu Arg Lys Leu Arg Lys Arg Leu 
1               5                   10                  15      


Leu Arg Asp Leu 
            20  


<210>  42
<211>  24
<212>  PRT
<213>  Synthetic

<400>  42

Lys Lys Lys Lys Leu Arg Val Arg Leu Ala Ser His Leu Arg Lys Leu 
1               5                   10                  15      


Arg Lys Arg Leu Leu Arg Asp Ala 
            20                  


<210>  43
<211>  24
<212>  PRT
<213>  Synthetic

<400>  43

Lys Lys Lys Lys Lys Lys Lys Lys Leu Arg Val Arg Leu Ala Ser His 
1               5                   10                  15      


Leu Arg Lys Leu Arg Lys Arg Leu 
            20                  


<210>  44
<211>  24
<212>  PRT
<213>  Synthetic

<400>  44

Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Leu Arg Val Arg 
1               5                   10                  15      


Leu Ala Ser His Leu Arg Lys Leu 
            20                  


<210>  45
<211>  36
<212>  PRT
<213>  Synthetic

<400>  45

Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys 
1               5                   10                  15      


Leu Arg Val Arg Leu Ala Ser His Leu Arg Lys Leu Arg Lys Arg Leu 
            20                  25                  30          


Leu Arg Asp Ala 
        35      


<210>  46
<211>  40
<212>  PRT
<213>  Synthetic

<400>  46

Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys 
1               5                   10                  15      


Lys Lys Lys Lys Leu Arg Val Arg Leu Ala Ser His Leu Arg Lys Leu 
            20                  25                  30          


Arg Lys Arg Leu Leu Arg Asp Ala 
        35                  40  


<210>  47
<211>  44
<212>  PRT
<213>  Synthetic

<400>  47

Lys Lys Lys Lys Ser Ser Val Ile Asp Ala Leu Gln Tyr Lys Leu Glu 
1               5                   10                  15      


Gly Thr Thr Arg Leu Thr Arg Lys Arg Gly Leu Lys Leu Ala Thr Ala 
            20                  25                  30          


Leu Ser Leu Ser Asn Lys Phe Val Glu Gly Ser His 
        35                  40                  


<210>  48
<211>  48
<212>  PRT
<213>  Synthetic

<400>  48

Lys Lys Lys Lys Lys Lys Lys Lys Ser Ser Val Ile Asp Ala Leu Gln 
1               5                   10                  15      


Tyr Lys Leu Glu Gly Thr Thr Arg Leu Thr Arg Lys Arg Gly Leu Lys 
            20                  25                  30          


Leu Ala Thr Ala Leu Ser Leu Ser Asn Lys Phe Val Glu Gly Ser His 
        35                  40                  45              


<210>  49
<211>  52
<212>  PRT
<213>  Synthetic

<400>  49

Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Ser Ser Val Ile 
1               5                   10                  15      


Asp Ala Leu Gln Tyr Lys Leu Glu Gly Thr Thr Arg Leu Thr Arg Lys 
            20                  25                  30          


Arg Gly Leu Lys Leu Ala Thr Ala Leu Ser Leu Ser Asn Lys Phe Val 
        35                  40                  45              


Glu Gly Ser His 
    50          


<210>  50
<211>  56
<212>  PRT
<213>  Synthetic

<400>  50

Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys 
1               5                   10                  15      


Ser Ser Val Ile Asp Ala Leu Gln Tyr Lys Leu Glu Gly Thr Thr Arg 
            20                  25                  30          


Leu Thr Arg Lys Arg Gly Leu Lys Leu Ala Thr Ala Leu Ser Leu Ser 
        35                  40                  45              


Asn Lys Phe Val Glu Gly Ser His 
    50                  55      


<210>  51
<211>  60
<212>  PRT
<213>  Synthetic

<400>  51

Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys 
1               5                   10                  15      


Lys Lys Lys Lys Ser Ser Val Ile Asp Ala Leu Gln Tyr Lys Leu Glu 
            20                  25                  30          


Gly Thr Thr Arg Leu Thr Arg Lys Arg Gly Leu Lys Leu Ala Thr Ala 
        35                  40                  45              


Leu Ser Leu Ser Asn Lys Phe Val Glu Gly Ser His 
    50                  55                  60  


<210>  52
<211>  20
<212>  PRT
<213>  Synthetic

<400>  52

Leu Arg Lys Leu Arg Lys Arg Leu Leu Arg Leu Arg Lys Leu Arg Lys 
1               5                   10                  15      


Arg Leu Leu Arg 
            20  


<210>  53
<211>  653
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Arg Pro Leu Arg Pro Arg Ala Ala Leu Leu Ala Leu Leu Ala Ser 
1               5                   10                  15      


Leu Leu Ala Ala Pro Pro Val Ala Pro Ala Glu Ala Pro His Leu Val 
            20                  25                  30          


His Val Asp Ala Ala Arg Ala Leu Trp Pro Leu Arg Arg Phe Trp Arg 
        35                  40                  45              


Ser Thr Gly Phe Cys Pro Pro Leu Pro His Ser Gln Ala Asp Gln Tyr 
    50                  55                  60                  


Val Leu Ser Trp Asp Gln Gln Leu Asn Leu Ala Tyr Val Gly Ala Val 
65                  70                  75                  80  


Pro His Arg Gly Ile Lys Gln Val Arg Thr His Trp Leu Leu Glu Leu 
                85                  90                  95      


Val Thr Thr Arg Gly Ser Thr Gly Arg Gly Leu Ser Tyr Asn Phe Thr 
            100                 105                 110         


His Leu Asp Gly Tyr Leu Asp Leu Leu Arg Glu Asn Gln Leu Leu Pro 
        115                 120                 125             


Gly Phe Glu Leu Met Gly Ser Ala Ser Gly His Phe Thr Asp Phe Glu 
    130                 135                 140                 


Asp Lys Gln Gln Val Phe Glu Trp Lys Asp Leu Val Ser Ser Leu Ala 
145                 150                 155                 160 


Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala His Val Ser Lys Trp Asn 
                165                 170                 175     


Phe Glu Thr Trp Asn Glu Pro Asp His His Asp Phe Asp Asn Val Ser 
            180                 185                 190         


Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr Asp Ala Cys Ser Glu Gly 
        195                 200                 205             


Leu Arg Ala Ala Ser Pro Ala Leu Arg Leu Gly Gly Pro Gly Asp Ser 
    210                 215                 220                 


Phe His Thr Pro Pro Arg Ser Pro Leu Ser Trp Gly Leu Leu Arg His 
225                 230                 235                 240 


Cys His Asp Gly Thr Asn Phe Phe Thr Gly Glu Ala Gly Val Arg Leu 
                245                 250                 255     


Asp Tyr Ile Ser Leu His Arg Lys Gly Ala Arg Ser Ser Ile Ser Ile 
            260                 265                 270         


Leu Glu Gln Glu Lys Val Val Ala Gln Gln Ile Arg Gln Leu Phe Pro 
        275                 280                 285             


Lys Phe Ala Asp Thr Pro Ile Tyr Asn Asp Glu Ala Asp Pro Leu Val 
    290                 295                 300                 


Gly Trp Ser Leu Pro Gln Pro Trp Arg Ala Asp Val Thr Tyr Ala Ala 
305                 310                 315                 320 


Met Val Val Lys Val Ile Ala Gln His Gln Asn Leu Leu Leu Ala Asn 
                325                 330                 335     


Thr Thr Ser Ala Phe Pro Tyr Ala Leu Leu Ser Asn Asp Asn Ala Phe 
            340                 345                 350         


Leu Ser Tyr His Pro His Pro Phe Ala Gln Arg Thr Leu Thr Ala Arg 
        355                 360                 365             


Phe Gln Val Asn Asn Thr Arg Pro Pro His Val Gln Leu Leu Arg Lys 
    370                 375                 380                 


Pro Val Leu Thr Ala Met Gly Leu Leu Ala Leu Leu Asp Glu Glu Gln 
385                 390                 395                 400 


Leu Trp Ala Glu Val Ser Gln Ala Gly Thr Val Leu Asp Ser Asn His 
                405                 410                 415     


Thr Val Gly Val Leu Ala Ser Ala His Arg Pro Gln Gly Pro Ala Asp 
            420                 425                 430         


Ala Trp Arg Ala Ala Val Leu Ile Tyr Ala Ser Asp Asp Thr Arg Ala 
        435                 440                 445             


His Pro Asn Arg Ser Val Ala Val Thr Leu Arg Leu Arg Gly Val Pro 
    450                 455                 460                 


Pro Gly Pro Gly Leu Val Tyr Val Thr Arg Tyr Leu Asp Asn Gly Leu 
465                 470                 475                 480 


Cys Ser Pro Asp Gly Glu Trp Arg Arg Leu Gly Arg Pro Val Phe Pro 
                485                 490                 495     


Thr Ala Glu Gln Phe Arg Arg Met Arg Ala Ala Glu Asp Pro Val Ala 
            500                 505                 510         


Ala Ala Pro Arg Pro Leu Pro Ala Gly Gly Arg Leu Thr Leu Arg Pro 
        515                 520                 525             


Ala Leu Arg Leu Pro Ser Leu Leu Leu Val His Val Cys Ala Arg Pro 
    530                 535                 540                 


Glu Lys Pro Pro Gly Gln Val Thr Arg Leu Arg Ala Leu Pro Leu Thr 
545                 550                 555                 560 


Gln Gly Gln Leu Val Leu Val Trp Ser Asp Glu His Val Gly Ser Lys 
                565                 570                 575     


Cys Leu Trp Thr Tyr Glu Ile Gln Phe Ser Gln Asp Gly Lys Ala Tyr 
            580                 585                 590         


Thr Pro Val Ser Arg Lys Pro Ser Thr Phe Asn Leu Phe Val Phe Ser 
        595                 600                 605             


Pro Asp Thr Gly Ala Val Ser Gly Ser Tyr Arg Val Arg Ala Leu Asp 
    610                 615                 620                 


Tyr Trp Ala Arg Pro Gly Pro Phe Ser Asp Pro Val Pro Tyr Leu Glu 
625                 630                 635                 640 


Val Pro Val Pro Arg Gly Pro Pro Ser Pro Gly Asn Pro 
                645                 650             


<210>  54
<211>  1962
<212>  DNA
<213>  Homo sapiens

<400>  54
atgcgtcccc tgcgcccccg cgccgcgctg ctggcgctcc tggcctcgct cctggccgcg       60

cccccggtgg ccccggccga ggccccgcac ctggtgcatg tggacgcggc ccgcgcgctg      120

tggcccctgc ggcgcttctg gaggagcaca ggcttctgcc ccccgctgcc acacagccag      180

gctgaccagt acgtcctcag ctgggaccag cagctcaacc tcgcctatgt gggcgccgtc      240

cctcaccgcg gcatcaagca ggtccggacc cactggctgc tggagcttgt caccaccagg      300

gggtccactg gacggggcct gagctacaac ttcacccacc tggacgggta cctggacctt      360

ctcagggaga accagctcct cccagggttt gagctgatgg gcagcgcctc gggccacttc      420

actgactttg aggacaagca gcaggtgttt gagtggaagg acttggtctc cagcctggcc      480

aggagataca tcggtaggta cggactggcg catgtttcca agtggaactt cgagacgtgg      540

aatgagccag accaccacga ctttgacaac gtctccatga ccatgcaagg cttcctgaac      600

tactacgatg cctgctcgga gggtctgcgc gccgccagcc ccgccctgcg gctgggaggc      660

cccggcgact ccttccacac cccaccgcga tccccgctga gctggggcct cctgcgccac      720

tgccacgacg gtaccaactt cttcactggg gaggcgggcg tgcggctgga ctacatctcc      780

ctccacagga agggtgcgcg cagctccatc tccatcctgg agcaggagaa ggtcgtcgcg      840

cagcagatcc ggcagctctt ccccaagttc gcggacaccc ccatttacaa cgacgaggcg      900

gacccgctgg tgggctggtc cctgccacag ccgtggaggg cggacgtgac ctacgcggcc      960

atggtggtga aggtcatcgc gcagcatcag aacctgctac tggccaacac cacctccgcc     1020

ttcccctacg cgctcctgag caacgacaat gccttcctga gctaccaccc gcaccccttc     1080

gcgcagcgca cgctcaccgc gcgcttccag gtcaacaaca cccgcccgcc gcacgtgcag     1140

ctgttgcgca agccggtgct cacggccatg gggctgctgg cgctgctgga tgaggagcag     1200

ctctgggccg aagtgtcgca ggccgggacc gtcctggaca gcaaccacac ggtgggcgtc     1260

ctggccagcg cccaccgccc ccagggcccg gccgacgcct ggcgcgccgc ggtgctgatc     1320

tacgcgagcg acgacacccg cgcccacccc aaccgcagcg tcgcggtgac cctgcggctg     1380

cgcggggtgc cccccggccc gggcctggtc tacgtcacgc gctacctgga caacgggctc     1440

tgcagccccg acggcgagtg gcggcgcctg ggccggcccg tcttccccac ggcagagcag     1500

ttccggcgca tgcgcgcggc tgaggacccg gtggccgcgg cgccccgccc cttacccgcc     1560

ggcggccgcc tgaccctgcg ccccgcgctg cggctgccgt cgcttttgct ggtgcacgtg     1620

tgtgcgcgcc ccgagaagcc gcccgggcag gtcacgcggc tccgcgccct gcccctgacc     1680

caagggcagc tggttctggt ctggtcggat gaacacgtgg gctccaagtg cctgtggaca     1740

tacgagatcc agttctctca ggacggtaag gcgtacaccc cggtcagcag gaagccatcg     1800

accttcaacc tctttgtgtt cagcccagac acaggtgctg tctctggctc ctaccgagtt     1860

cgagccctgg actactgggc ccgaccaggc cccttctcgg accctgtgcc gtacctggag     1920

gtccctgtgc caagagggcc cccatccccg ggcaatccat ga                        1962


<210>  55
<211>  550
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Pro Pro Pro Arg Thr Gly Arg Gly Leu Leu Trp Leu Gly Leu Val 
1               5                   10                  15      


Leu Ser Ser Val Cys Val Ala Leu Gly Ser Glu Thr Gln Ala Asn Ser 
            20                  25                  30          


Thr Thr Asp Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg 
        35                  40                  45              


Pro Ser Leu Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile 
    50                  55                  60                  


Asp Gln Leu Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln 
65                  70                  75                  80  


Gln Ala Val Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg 
                85                  90                  95      


Pro Asp Thr Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His 
            100                 105                 110         


Ala Gly Asn Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr 
        115                 120                 125             


Val Thr Met Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn 
    130                 135                 140                 


His Thr Asp Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro 
145                 150                 155                 160 


Ser Ser Glu Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly 
                165                 170                 175     


Glu Leu His Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro 
            180                 185                 190         


Glu Gly Thr Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu 
        195                 200                 205             


Leu Glu Lys Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly 
    210                 215                 220                 


Tyr His Lys Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys 
225                 230                 235                 240 


Leu Tyr Pro Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro 
                245                 250                 255     


Asp Gly Leu Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln 
            260                 265                 270         


Arg Glu Asp Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile 
        275                 280                 285             


Pro Val Asp Phe Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val 
    290                 295                 300                 


Ser Tyr Leu Asp Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp 
305                 310                 315                 320 


Leu Gln Leu Ala Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly 
                325                 330                 335     


Trp Ala Leu Gly Glu His Gly Glu Trp Ala Lys Tyr Ser Asn Phe Asp 
            340                 345                 350         


Val Ala Thr His Val Pro Leu Ile Phe Tyr Val Pro Gly Arg Thr Ala 
        355                 360                 365             


Ser Leu Pro Glu Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp Pro Phe 
    370                 375                 380                 


Asp Ser Ala Ser Gln Leu Met Glu Pro Gly Arg Gln Ser Met Asp Leu 
385                 390                 395                 400 


Val Glu Leu Val Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala Gly Leu 
                405                 410                 415     


Gln Val Pro Pro Arg Cys Pro Val Pro Ser Phe His Val Glu Leu Cys 
            420                 425                 430         


Arg Glu Gly Lys Asn Leu Leu Lys His Phe Arg Phe Arg Asp Leu Glu 
        435                 440                 445             


Glu Asp Pro Tyr Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala Tyr Ser 
    450                 455                 460                 


Gln Tyr Pro Arg Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp Lys Pro 
465                 470                 475                 480 


Ser Leu Lys Asp Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr Ile Asp 
                485                 490                 495     


Tyr Arg Tyr Thr Val Trp Val Gly Phe Asn Pro Asp Glu Phe Leu Ala 
            500                 505                 510         


Asn Phe Ser Asp Ile His Ala Gly Glu Leu Tyr Phe Val Asp Ser Asp 
        515                 520                 525             


Pro Leu Gln Asp His Asn Met Tyr Asn Asp Ser Gln Gly Gly Asp Leu 
    530                 535                 540                 


Phe Gln Leu Leu Met Pro 
545                 550 


<210>  56
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asn Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Gln Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Leu Ala Trp Ala Val Ala 
            340                 345                 350         


Met Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile Ala 
        355                 360                 365             


Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Trp Thr 
385                 390                 395                 400 


Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
            420                 425                 


