                         SEQUENCE LISTING

<110>  Blagden, Sarah  
 
<120>  METHOD

<130>  P60722WO

<150>  GB1419932.7
<151>  2014-11-10

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  6607
<212>  DNA
<213>  Homo sapiens

<400>  1
gtgaccccag gccctggtca ctccatgctt tggagggtgc ttttgtcaaa gaggcctcct       60

ttccctcacc cagagctgga tttccaagag gctcccatac ctagctgccc tggcagactc      120

ccagggagga aaaacagcgt ggccttggca gctgccccga ggaaggagcc cacaggtgac      180

agggagaagc cattgccatt ccctgtcctg gcccccttca gcaaccctga acactctgct      240

ccagccaagg tggtgagggc agctgttcct aaacagcgca aaggcagcaa ggttggtgac      300

tttggagatg caatcaattg gcccacacct ggagagatag cccacaagag tgttcagcca      360

cagtcccaca agcctcagcc tacccgtaaa ctgccaccca agaaggacat gaaggaacag      420

gagaaaggag aagggagtga tagtaaggag agtccaaaaa ccaaatcaga tgaatcaggg      480

gaggaaaaga atggagatga ggattgccag cgaggcgggc agaagaagaa aggaaacaaa      540

cacaagtggg ttccattaca aatagacatg aagcctgaag tgcccagaga gaaactggct      600

tcacgcccca ctcgcccacc ggagcctaga cacatacctg ccaatcgcgg agagatcaaa      660

gggtctgagt ctgccaccta cgtgcccgtg gcccccccca ccccagcctg gcaaccagag      720

atcaaaccgg agcctgcctg gcacgaccag gatgagacat cgagtgtgaa gagtgatggg      780

gctggtgggg cgcgggcttc cttccgtggc cgtggacggg ggcgtggtcg cggccgggga      840

cgcggccggg gtggcactcg aacccatttt gactaccagt ttggctaccg aaagtttgat      900

ggtgtggagg ggcctcgtac gcccaagtac atgaacaaca tcacctacta ctttgacaat      960

gtcagcagca ccgagcttta cagtgtggat caggaactgc tcaaagacta catcaagcgc     1020

cagattgaat actacttcag cgtggacaat ttagagcgag acttcttcct gcgaaggaaa     1080

atggatgctg atggtttcct acccatcacc cttattgctt ccttccaccg agtgcaggcc     1140

cttaccactg acatttcact catctttgcg gccctaaagg acagcaaggt ggtggagatc     1200

gttgatgaga aagttcgtag gagggaggaa ccagaaaagt ggcctcttcc cccaatagtg     1260

gattattcac agactgattt ctcccagctt ctcaactgcc ctgaatttgt tccccgtcag     1320

cactaccaaa aggagacaga gtcggcacct ggctctcctc gtgcagtcac cccagtgcca     1380

accaaaacag aggaggtcag caacctaaag acactaccca agggcctgtc tgccagcctg     1440

cctgacctgg attctgagaa ctggattgaa gtgaagaaga ggcctcggcc atccccagca     1500

cggcccaaga agtcagagga gtccagattt tcccacctga cctctctgcc tcagcagctg     1560

ccttcccagc agctgatgtc caaggatcag gatgagcaag aggaactgga ttttctgttt     1620

gacgaggaga tggagcagat ggatgggcgg aagaacacct tcactgcctg gtctgatgag     1680

gaatctgact atgagattga tgacagggat gtcaacaaga tcctcattgt cacccagaca     1740

ccacattaca tgcgccggca cccagggggg gaccgcacag gcaaccacac ctcgcgtgcc     1800

aagatgagcg ccgaactggc caaggtcatt aatgatggcc tcttctacta tgagcaggac     1860

ctgtgggctg aaaagtttga acctgagtat tcccagatca agcaagaagt cgagaacttc     1920

aaaaaggtca atatgatcag ccgggagcag tttgacacac tgacccctga gccccctgtg     1980

gatcccaacc aggaagttcc tcctgggcca cctcggttcc agcaagttcc tacggatgcc     2040

ctggccaaca agttgtttgg tgctcctgag ccctccacca tcgcccgctc tctaccaacc     2100

actgtcccag agtcaccaaa ctaccgcaac accaggaccc ctcgcactcc ccggacacca     2160

cagctcaaag actcaagcca gacatcacgg ttttacccag tggtgaaaga aggacggaca     2220

ctggatgcca agatgcctcg aaaaagaaag acaagacaca gttcaaaccc acccttggag     2280

agccatgtgg gctgggtgat ggattcccgt gagcacaggc cccgtactgc ttccatcagc     2340

tccagcccct cagaagggac gcctacagtt ggcagctatg gctgtacccc tcagtcattg     2400

cccaagttcc agcatccttc ccatgaactg ctcaaggaaa atggcttcac acaacacgtc     2460

taccataagt atcgtaggcg ctgccttaat gagcggaaac gcttgggcat tggccagtct     2520

caggagatga acacactctt ccgcttctgg tccttcttcc tccgagatca cttcaacaaa     2580

aagatgtatg aggagttcaa gcagctggct ctggaggacg ccaaagaagg ctacagatat     2640

ggtttggagt gcctttttcg atactacagt tatggcctgg aaaagaagtt ccggctggac     2700

atattcaagg attttcagga ggaaacggtg aaggactatg aagctggcca actgtatggg     2760

ctggagaagt tctgggcctt cttgaaatat tccaaagcca aaaatttgga cattgacccc     2820

aaactgcaag aatacctcgg caaattccga cgtcttgaag acttccgagt agatcccccc     2880

atgggtgagg agggcaacca caagcgacac tcagtggtag caggaggtgg cggcggtgag     2940

ggcaggaagc ggtgcccctc ccagtcttcc agcaggcctg ctgccatgat cagccaaccc     3000

cctacaccac ccaccggcca gcctgtccgg gaagatgcca aatggacaag ccagcactcg     3060

aacacacaga ctttgggaaa gtgaaaagct ccttagccct ggggcttgag gggggaaagg     3120

ggtagggtgg gtaagagtcc atgggggtgc ccagtcccag gagaggggac aatgaaggga     3180

caggcctgga gttactagga caggcctttg tgctgagtag caatgtatac accatttggg     3240

ctatcagagg tacccctggg caggagcctc tacatcccct tccccctcct ctctccatga     3300

ctcttgacat cctagcttct tctaaggggg gagggaaagg ggggagattt ttatatatat     3360

atacatatat atatatcaag ttttaaatta ttgatagttc atctggatta ccaaaatcac     3420

tctgcagccc tgcccgaggc tagtaggctg caaccctggt ccccacccct aacctcctgc     3480

tccccctcaa gccaactatg cagcccacaa gaaggccctg cgggcccccc cattgcccag     3540

cactgtctca tagaaggctc tggtggtacc tctgggcccc aggagcatca gccccttgat     3600

catctggggt ttgtcatcac catattttct ccctgctgtt cccaccatgc ccttctgcca     3660

tcttctggga gaaggaaacc aaaggatcta aaactggggt ttgggggaag gtttcagcct     3720

ctccccactc cccttgcccc acacccttta ctccccagcc cagagagacg ctgcttttac     3780

caggaaagac tattgaaaga tgttttattt tatttttctc tgacctttcc atccttgaaa     3840

aaatggggaa aaaagaagaa aaaagacaaa atcgaccata aaagaccaaa aaaaaaaaaa     3900

aaatcagaaa acccccacct aatccacaga aagtaatgtc tttcccctcc ccttggaatt     3960

tttgttttgt ttttggaaat aatatttttt taaaagttgc cttattgtgg agcgggaatc     4020

tgaaataccc aaatgcctgt tttcctcggt ggagtcaacc cgaagagctc ccaccttctc     4080

tggatgtgcc tgggcttgga ctggctagaa tctttctctg gactgttgca tgtacagtgc     4140

ctccatcctg gaggcaagag agttgggagt ggctcgaatc agagccgtgc ccaagatatc     4200

cctgctgttg catcgtttga agctgacgtc ctgtgtctgt acactgctgc cactgttgtg     4260

tcctcgctct gcttgctgtt gcctcacgcc aggccccgtc ctgccgtgac acccttcatc     4320

ctacccttgg aaccccaagg ccaagttggt tcaaactgtt ggagaacaga gttggcctgc     4380

atctggaaca cacttgtcct cagcttacca tctcctcaca ccccagagtg gaaaggtgaa     4440

cacctgcagc tgaggcttgg aaacgtttct tgtgttgccc tgaaaaatct ttgagacctc     4500

agggaggctc tgtctctctt aaaaggtgga gaaagatgcc attctctccc taaggtctgg     4560

tggagtctcc ccatcttgca tacccttctg caagccatct atctctgctc actctccaat     4620

tgacccgcct gggaacaagg gatgaggagg agttgggggc tggggggaat cctgccagtt     4680

ggtgaagccc tgtggcagga aggtatatgt ggacatagag tatacctgat tctctttctt     4740

cagccactga ctgcttgggt tgggctgtga atgataatgg aatggctgga gtctgctgtt     4800

gtcagaaggc agggagggtg atgaaggact gacccacatg gactgggatg tgtgtcggtt     4860

atgggcatga ctgcacgttc actctcagtg ggatctgggc aacatggagt tcattgtcct     4920

gttgcttact tactgcaatg tctttggccc tccttttcaa ctggttcctc tgttgggccc     4980

aaaggttggg agtaggagac agtatcccag gctgacaagg gcttgccctt taccttgggc     5040

accttgttaa tttttagcct gtgcccttcc ccacctttgc cctcccagtg gttggtatgt     5100

gggaagccca tctcagttcc tgtgacttca tgtctcaaac caaggatgag cgtctggtct     5160

ctgctatgat ggtggtatcc gaggcctttc cctgcccagt ctggtgcctg ccccacattg     5220

taccggacac tggattcctg gacccccttc tcctttcctt tctttccttc aggtcacgca     5280

gccctgtact gtatccagca ccacagaaac ctcagtgttt ttcctctgct ggtttggggc     5340

acaaggaagc cttagggtat ggggaaaggc tgttattacc tagagtttac tcccaggcca     5400

gggggctgcc atcttcttca cagacatccc tgaaaggaag cccctttggg gcagggaggt     5460

gaggacttca tctcaacatc ggctggtggt tggtagggga gctttttctt ttctttcctt     5520

tttttttgtt tttgtttttg tttttgtttt tggtaacatg ttaggagtta atgttgcaaa     5580

gagtagttta catcttcact ttctgaagac acttgaattt aggaccgatg tatctgtgac     5640

aagcatgcca gaagtggcag gggccatcag ggctaaccac ttcacaccta ccatcgtccc     5700

atggggatcc aagacctgag ataaagcaac agcctgccca gatccctctg ttcatcctat     5760

cccttccaag gttggtccat gccaacataa cctctgggca tcagacatca gcaggtctgt     5820

gtgcctcagc cctgttaagg ggcaggtttc tctttagccc tcttcctgca cttgggagca     5880

aaggcactac cagtagagaa gggccatcca gccgtgcccc agcctggacc cctggggctc     5940

agatagaggt gctgagcccc tgtgtcaaag ttgttaaatg tttttgtttt gttccattgt     6000

agctcttttt tttttttttt cccctttcct ggtgattgat tttacaaaag aaagtaagct     6060

gcttagaagg ccctggaagg gaagtgagga ggagggacaa ggaagatgac tagttacgga     6120

gggtgagggt tgttttttgc caaaaagcct gggtagagtg atctgaatta tctggcaccc     6180

tcctgaatgg aaccccagag tacctcctgt gtggaagggt ccctggattt tccctaacac     6240

ccaccctctc ccccttcagc catgctgatg gcagagaaga taagaacttg gagcccattt     6300

ctcactggag aggaaaactt gtcatctggc tttgcggaga aggttccacc ttacgctcgt     6360

agtacattat ctttactatg tgctaggata tcatatttaa aaggacaaaa aaatgtaaaa     6420

tacttgaatg agcttgtatt ataacattaa tattattgag agtatctgct ttccaggctg     6480

aagtgattca ttcattattc tagtcctgct ttagtccttt gtaatttgtg gtaattatgc     6540

ttttcttttt aatacaaaaa aatgtataaa aataaacact tgaaaaggca aaataaaaaa     6600

aaaaaaa                                                               6607


<210>  2
<211>  891
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Glu Gln Glu Lys Gly Glu Gly Ser Asp Ser Lys Glu Ser Pro 
1               5                   10                  15      


Lys Thr Lys Ser Asp Glu Ser Gly Glu Glu Lys Asn Gly Asp Glu Asp 
            20                  25                  30          


Cys Gln Arg Gly Gly Gln Lys Lys Lys Gly Asn Lys His Lys Trp Val 
        35                  40                  45              


Pro Leu Gln Ile Asp Met Lys Pro Glu Val Pro Arg Glu Lys Leu Ala 
    50                  55                  60                  


Ser Arg Pro Thr Arg Pro Pro Glu Pro Arg His Ile Pro Ala Asn Arg 
65                  70                  75                  80  


Gly Glu Ile Lys Gly Ser Glu Ser Ala Thr Tyr Val Pro Val Ala Pro 
                85                  90                  95      


Pro Thr Pro Ala Trp Gln Pro Glu Ile Lys Pro Glu Pro Ala Trp His 
            100                 105                 110         


Asp Gln Asp Glu Thr Ser Ser Val Lys Ser Asp Gly Ala Gly Gly Ala 
        115                 120                 125             


Arg Ala Ser Phe Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly 
    130                 135                 140                 


Arg Gly Arg Gly Gly Thr Arg Thr His Phe Asp Tyr Gln Phe Gly Tyr 
145                 150                 155                 160 


Arg Lys Phe Asp Gly Val Glu Gly Pro Arg Thr Pro Lys Tyr Met Asn 
                165                 170                 175     


Asn Ile Thr Tyr Tyr Phe Asp Asn Val Ser Ser Thr Glu Leu Tyr Ser 
            180                 185                 190         


Val Asp Gln Glu Leu Leu Lys Asp Tyr Ile Lys Arg Gln Ile Glu Tyr 
        195                 200                 205             


Tyr Phe Ser Val Asp Asn Leu Glu Arg Asp Phe Phe Leu Arg Arg Lys 
    210                 215                 220                 


Met Asp Ala Asp Gly Phe Leu Pro Ile Thr Leu Ile Ala Ser Phe His 
225                 230                 235                 240 


Arg Val Gln Ala Leu Thr Thr Asp Ile Ser Leu Ile Phe Ala Ala Leu 
                245                 250                 255     


Lys Asp Ser Lys Val Val Glu Ile Val Asp Glu Lys Val Arg Arg Arg 
            260                 265                 270         


Glu Glu Pro Glu Lys Trp Pro Leu Pro Pro Ile Val Asp Tyr Ser Gln 
        275                 280                 285             


Thr Asp Phe Ser Gln Leu Leu Asn Cys Pro Glu Phe Val Pro Arg Gln 
    290                 295                 300                 


His Tyr Gln Lys Glu Thr Glu Ser Ala Pro Gly Ser Pro Arg Ala Val 
305                 310                 315                 320 


Thr Pro Val Pro Thr Lys Thr Glu Glu Val Ser Asn Leu Lys Thr Leu 
                325                 330                 335     


Pro Lys Gly Leu Ser Ala Ser Leu Pro Asp Leu Asp Ser Glu Asn Trp 
            340                 345                 350         


Ile Glu Val Lys Lys Arg Pro Arg Pro Ser Pro Ala Arg Pro Lys Lys 
        355                 360                 365             


Ser Glu Glu Ser Arg Phe Ser His Leu Thr Ser Leu Pro Gln Gln Leu 
    370                 375                 380                 


Pro Ser Gln Gln Leu Met Ser Lys Asp Gln Asp Glu Gln Glu Glu Leu 
385                 390                 395                 400 


Asp Phe Leu Phe Asp Glu Glu Met Glu Gln Met Asp Gly Arg Lys Asn 
                405                 410                 415     


Thr Phe Thr Ala Trp Ser Asp Glu Glu Ser Asp Tyr Glu Ile Asp Asp 
            420                 425                 430         


Arg Asp Val Asn Lys Ile Leu Ile Val Thr Gln Thr Pro His Tyr Met 
        435                 440                 445             


Arg Arg His Pro Gly Gly Asp Arg Thr Gly Asn His Thr Ser Arg Ala 
    450                 455                 460                 


Lys Met Ser Ala Glu Leu Ala Lys Val Ile Asn Asp Gly Leu Phe Tyr 
465                 470                 475                 480 


Tyr Glu Gln Asp Leu Trp Ala Glu Lys Phe Glu Pro Glu Tyr Ser Gln 
                485                 490                 495     


Ile Lys Gln Glu Val Glu Asn Phe Lys Lys Val Asn Met Ile Ser Arg 
            500                 505                 510         


Glu Gln Phe Asp Thr Leu Thr Pro Glu Pro Pro Val Asp Pro Asn Gln 
        515                 520                 525             


Glu Val Pro Pro Gly Pro Pro Arg Phe Gln Gln Val Pro Thr Asp Ala 
    530                 535                 540                 


Leu Ala Asn Lys Leu Phe Gly Ala Pro Glu Pro Ser Thr Ile Ala Arg 
545                 550                 555                 560 


Ser Leu Pro Thr Thr Val Pro Glu Ser Pro Asn Tyr Arg Asn Thr Arg 
                565                 570                 575     


Thr Pro Arg Thr Pro Arg Thr Pro Gln Leu Lys Asp Ser Ser Gln Thr 
            580                 585                 590         


Ser Arg Phe Tyr Pro Val Val Lys Glu Gly Arg Thr Leu Asp Ala Lys 
        595                 600                 605             


Met Pro Arg Lys Arg Lys Thr Arg His Ser Ser Asn Pro Pro Leu Glu 
    610                 615                 620                 


Ser His Val Gly Trp Val Met Asp Ser Arg Glu His Arg Pro Arg Thr 
625                 630                 635                 640 


Ala Ser Ile Ser Ser Ser Pro Ser Glu Gly Thr Pro Thr Val Gly Ser 
                645                 650                 655     


Tyr Gly Cys Thr Pro Gln Ser Leu Pro Lys Phe Gln His Pro Ser His 
            660                 665                 670         


Glu Leu Leu Lys Glu Asn Gly Phe Thr Gln His Val Tyr His Lys Tyr 
        675                 680                 685             


Arg Arg Arg Cys Leu Asn Glu Arg Lys Arg Leu Gly Ile Gly Gln Ser 
    690                 695                 700                 


Gln Glu Met Asn Thr Leu Phe Arg Phe Trp Ser Phe Phe Leu Arg Asp 
705                 710                 715                 720 


His Phe Asn Lys Lys Met Tyr Glu Glu Phe Lys Gln Leu Ala Leu Glu 
                725                 730                 735     


Asp Ala Lys Glu Gly Tyr Arg Tyr Gly Leu Glu Cys Leu Phe Arg Tyr 
            740                 745                 750         


Tyr Ser Tyr Gly Leu Glu Lys Lys Phe Arg Leu Asp Ile Phe Lys Asp 
        755                 760                 765             


Phe Gln Glu Glu Thr Val Lys Asp Tyr Glu Ala Gly Gln Leu Tyr Gly 
    770                 775                 780                 


Leu Glu Lys Phe Trp Ala Phe Leu Lys Tyr Ser Lys Ala Lys Asn Leu 
785                 790                 795                 800 


Asp Ile Asp Pro Lys Leu Gln Glu Tyr Leu Gly Lys Phe Arg Arg Leu 
                805                 810                 815     


Glu Asp Phe Arg Val Asp Pro Pro Met Gly Glu Glu Gly Asn His Lys 
            820                 825                 830         


Arg His Ser Val Val Ala Gly Gly Gly Gly Gly Glu Gly Arg Lys Arg 
        835                 840                 845             


Cys Pro Ser Gln Ser Ser Ser Arg Pro Ala Ala Met Ile Ser Gln Pro 
    850                 855                 860                 


Pro Thr Pro Pro Thr Gly Gln Pro Val Arg Glu Asp Ala Lys Trp Thr 
865                 870                 875                 880 


Ser Gln His Ser Asn Thr Gln Thr Leu Gly Lys 
                885                 890     


<210>  3
<211>  1158
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly Phe Thr Ala Ala Ala Ser Asn Trp Glu Gly Ala Ala Pro Arg Val 
1               5                   10                  15      


Asn Pro Asp Pro Ser Leu Gln Gly Leu Gly Pro Ser Ala Pro Glu Glu 
            20                  25                  30          


Gly Val Ala Gly Ala Leu Leu Ala Lys Phe Glu Ala Gly Glu Ala Ala 
        35                  40                  45              


Ser Gly Ala Pro Gly Phe Ser Gly Gly Ala Gly Ala Gln Met Ala Thr 
    50                  55                  60                  


Gln Val Glu Pro Leu Leu Pro Gly Gly Ala Thr Leu Leu Gln Ala Glu 
65                  70                  75                  80  


Glu His Gly Gly Leu Val Arg Lys Lys Pro Pro Pro Ala Pro Glu Gly 
                85                  90                  95      


Lys Gly Glu Pro Gly Pro Asn Asp Val Arg Gly Gly Glu Pro Asp Gly 
            100                 105                 110         


Ser Ala Arg Arg Pro Arg Pro Pro Cys Ala Lys Pro His Lys Glu Gly 
        115                 120                 125             


Thr Gly Gln Gln Glu Arg Glu Ser Pro Arg Pro Leu Gln Leu Pro Gly 
    130                 135                 140                 


Ala Glu Gly Pro Ala Ile Ser Asp Gly Glu Glu Gly Gly Gly Glu Pro 
145                 150                 155                 160 


Gly Ala Gly Gly Gly Ala Ala Gly Ala Ala Gly Ala Gly Arg Arg Asp 
                165                 170                 175     


Phe Val Glu Ala Pro Pro Pro Lys Val Asn Pro Trp Thr Lys Asn Ala 
            180                 185                 190         


Leu Pro Pro Val Leu Thr Thr Val Asn Gly Gln Ser Pro Pro Glu His 
        195                 200                 205             


Ser Ala Pro Ala Lys Val Val Arg Ala Ala Val Pro Lys Gln Arg Lys 
    210                 215                 220                 


Gly Ser Lys Val Gly Asp Phe Gly Asp Ala Ile Asn Trp Pro Thr Pro 
225                 230                 235                 240 


Gly Glu Ile Ala His Lys Ser Val Gln Pro Gln Ser His Lys Pro Gln 
                245                 250                 255     


Pro Thr Arg Lys Leu Pro Pro Lys Lys Asp Met Lys Glu Gln Glu Lys 
            260                 265                 270         


Gly Glu Gly Ser Asp Ser Lys Glu Ser Pro Lys Thr Lys Ser Asp Glu 
        275                 280                 285             


Ser Gly Glu Glu Lys Asn Gly Asp Glu Asp Cys Gln Arg Gly Gly Gln 
    290                 295                 300                 


Lys Lys Lys Gly Asn Lys His Lys Trp Val Pro Leu Gln Ile Asp Met 
305                 310                 315                 320 


Lys Pro Glu Val Pro Arg Glu Lys Leu Ala Ser Arg Pro Thr Arg Pro 
                325                 330                 335     


Pro Glu Pro Arg His Ile Pro Ala Asn Arg Gly Glu Ile Lys Gly Ser 
            340                 345                 350         


Glu Ser Ala Thr Tyr Val Pro Val Ala Pro Pro Thr Pro Ala Trp Gln 
        355                 360                 365             


Pro Glu Ile Lys Pro Glu Pro Ala Trp His Asp Gln Asp Glu Thr Ser 
    370                 375                 380                 


Ser Val Lys Ser Asp Gly Ala Gly Gly Ala Arg Ala Ser Phe Arg Gly 
385                 390                 395                 400 


Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Gly Thr 
                405                 410                 415     


Arg Thr His Phe Asp Tyr Gln Phe Gly Tyr Arg Lys Phe Asp Gly Val 
            420                 425                 430         


Glu Gly Pro Arg Thr Pro Lys Tyr Met Asn Asn Ile Thr Tyr Tyr Phe 
        435                 440                 445             


Asp Asn Val Ser Ser Thr Glu Leu Tyr Ser Val Asp Gln Glu Leu Leu 
    450                 455                 460                 


Lys Asp Tyr Ile Lys Arg Gln Ile Glu Tyr Tyr Phe Ser Val Asp Asn 
465                 470                 475                 480 


Leu Glu Arg Asp Phe Phe Leu Arg Arg Lys Met Asp Ala Asp Gly Phe 
                485                 490                 495     


Leu Pro Ile Thr Leu Ile Ala Ser Phe His Arg Val Gln Ala Leu Thr 
            500                 505                 510         


Thr Asp Ile Ser Leu Ile Phe Ala Ala Leu Lys Asp Ser Lys Val Val 
        515                 520                 525             


Glu Ile Val Asp Glu Lys Val Arg Arg Arg Glu Glu Pro Glu Lys Trp 
    530                 535                 540                 


Pro Leu Pro Pro Ile Val Asp Tyr Ser Gln Thr Asp Phe Ser Gln Leu 
545                 550                 555                 560 


Leu Asn Cys Pro Glu Phe Val Pro Arg Gln His Tyr Gln Lys Glu Thr 
                565                 570                 575     


Glu Ser Ala Pro Gly Ser Pro Arg Ala Val Thr Pro Val Pro Thr Lys 
            580                 585                 590         


Thr Glu Glu Val Ser Asn Leu Lys Thr Leu Pro Lys Gly Leu Ser Ala 
        595                 600                 605             


Ser Leu Pro Asp Leu Asp Ser Glu Asn Trp Ile Glu Val Lys Lys Arg 
    610                 615                 620                 


Pro Arg Pro Ser Pro Ala Arg Pro Lys Lys Ser Glu Glu Ser Arg Phe 
625                 630                 635                 640 


Ser His Leu Thr Ser Leu Pro Gln Gln Leu Pro Ser Gln Gln Leu Met 
                645                 650                 655     


Ser Lys Asp Gln Asp Glu Gln Glu Glu Leu Asp Phe Leu Phe Asp Glu 
            660                 665                 670         


Glu Met Glu Gln Met Asp Gly Arg Lys Asn Thr Phe Thr Ala Trp Ser 
        675                 680                 685             


Asp Glu Glu Ser Asp Tyr Glu Ile Asp Asp Arg Asp Val Asn Lys Ile 
    690                 695                 700                 


Leu Ile Val Thr Gln Thr Pro His Tyr Met Arg Arg His Pro Gly Gly 
705                 710                 715                 720 


Asp Arg Thr Gly Asn His Thr Ser Arg Ala Lys Met Ser Ala Glu Leu 
                725                 730                 735     


Ala Lys Val Ile Asn Asp Gly Leu Phe Tyr Tyr Glu Gln Asp Leu Trp 
            740                 745                 750         


Ala Glu Lys Phe Glu Pro Glu Tyr Ser Gln Ile Lys Gln Glu Val Glu 
        755                 760                 765             


Asn Phe Lys Lys Val Asn Met Ile Ser Arg Glu Gln Phe Asp Thr Leu 
    770                 775                 780                 


Thr Pro Glu Pro Pro Val Asp Pro Asn Gln Glu Val Pro Pro Gly Pro 
785                 790                 795                 800 


Pro Arg Phe Gln Gln Val Pro Thr Asp Ala Leu Ala Asn Lys Leu Phe 
                805                 810                 815     


Gly Ala Pro Glu Pro Ser Thr Ile Ala Arg Ser Leu Pro Thr Thr Val 
            820                 825                 830         


Pro Glu Ser Pro Asn Tyr Arg Asn Thr Arg Thr Pro Arg Thr Pro Arg 
        835                 840                 845             


Thr Pro Gln Leu Lys Asp Ser Ser Gln Thr Ser Arg Phe Tyr Pro Val 
    850                 855                 860                 


Val Lys Glu Gly Arg Thr Leu Asp Ala Lys Val Met Pro Arg Lys Arg 
865                 870                 875                 880 


Lys Thr Arg His Ser Ser Asn Pro Pro Leu Glu Ser His Val Gly Trp 
                885                 890                 895     


Val Met Asp Ser Arg Glu His Arg Pro Arg Thr Ala Ser Ile Ser Ser 
            900                 905                 910         


Ser Pro Ser Glu Gly Thr Pro Thr Val Gly Ser Tyr Gly Cys Thr Pro 
        915                 920                 925             


Gln Ser Leu Pro Lys Phe Gln His Pro Ser His Glu Leu Leu Lys Glu 
    930                 935                 940                 


Asn Gly Phe Thr Gln His Val Tyr His Lys Tyr Arg Arg Arg Cys Leu 
945                 950                 955                 960 


Asn Glu Arg Lys Arg Leu Gly Ile Gly Gln Ser Gln Glu Met Asn Thr 
                965                 970                 975     


Leu Phe Arg Phe Trp Ser Phe Phe Leu Arg Asp His Phe Asn Lys Lys 
            980                 985                 990         


Met Tyr Glu Glu Phe Lys Gln Leu  Ala Leu Glu Asp Ala  Lys Glu Gly 
        995                 1000                 1005             


Tyr Arg  Tyr Gly Leu Glu Cys  Leu Phe Arg Tyr Tyr  Ser Tyr Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Phe Arg Leu  Asp Ile Phe Lys Asp  Phe Gln Glu 
    1025                 1030                 1035             


Glu Thr  Val Lys Asp Tyr Glu  Ala Gly Gln Leu Tyr  Gly Leu Glu 
    1040                 1045                 1050             


Lys Phe  Trp Ala Phe Leu Lys  Tyr Ser Lys Ala Lys  Asn Leu Asp 
    1055                 1060                 1065             


Ile Asp  Pro Lys Leu Gln Glu  Tyr Leu Gly Lys Phe  Arg Arg Leu 
    1070                 1075                 1080             


Glu Asp  Phe Arg Val Asp Pro  Pro Met Gly Glu Glu  Gly Asn His 
    1085                 1090                 1095             


Lys Arg  His Ser Val Val Ala  Gly Gly Gly Gly Gly  Glu Gly Arg 
    1100                 1105                 1110             


Lys Arg  Cys Pro Ser Gln Ser  Ser Ser Arg Pro Ala  Ala Met Ile 
    1115                 1120                 1125             


Ser Gln  Pro Pro Thr Pro Pro  Thr Gly Gln Pro Val  Arg Glu Asp 
    1130                 1135                 1140             


Ala Lys  Trp Thr Ser Gln His  Ser Asn Thr Gln Thr  Leu Gly Lys 
    1145                 1150                 1155             


<210>  4
<211>  1019
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Leu Trp Arg Val Leu Leu Ser Lys Arg Pro Pro Phe Pro His Pro 
1               5                   10                  15      


Glu Leu Asp Phe Gln Glu Ala Pro Ile Pro Ser Cys Pro Gly Arg Leu 
            20                  25                  30          


Pro Gly Arg Lys Asn Ser Val Ala Leu Ala Ala Ala Pro Arg Lys Glu 
        35                  40                  45              


Pro Thr Gly Asp Arg Glu Lys Pro Leu Pro Phe Pro Val Leu Ala Pro 
    50                  55                  60                  


Phe Ser Asn Pro Glu His Ser Ala Pro Ala Lys Val Val Arg Ala Ala 
65                  70                  75                  80  


Val Pro Lys Gln Arg Lys Gly Ser Lys Val Gly Asp Phe Gly Asp Ala 
                85                  90                  95      


Ile Asn Trp Pro Thr Pro Gly Glu Ile Ala His Lys Ser Val Gln Pro 
            100                 105                 110         


Gln Ser His Lys Pro Gln Pro Thr Arg Lys Leu Pro Pro Lys Lys Asp 
        115                 120                 125             


Met Lys Glu Gln Glu Lys Gly Glu Gly Ser Asp Ser Lys Glu Ser Pro 
    130                 135                 140                 


Lys Thr Lys Ser Asp Glu Ser Gly Glu Glu Lys Asn Gly Asp Glu Asp 
145                 150                 155                 160 


Cys Gln Arg Gly Gly Gln Lys Lys Lys Gly Asn Lys His Lys Trp Val 
                165                 170                 175     


Pro Leu Gln Ile Asp Met Lys Pro Glu Val Pro Arg Glu Lys Leu Ala 
            180                 185                 190         


Ser Arg Pro Thr Arg Pro Pro Glu Pro Arg His Ile Pro Ala Asn Arg 
        195                 200                 205             


Gly Glu Ile Lys Gly Ser Glu Ser Ala Thr Tyr Val Pro Val Ala Pro 
    210                 215                 220                 


Pro Thr Pro Ala Trp Gln Pro Glu Ile Lys Pro Glu Pro Ala Trp His 
225                 230                 235                 240 


Asp Gln Asp Glu Thr Ser Ser Val Lys Ser Asp Gly Ala Gly Gly Ala 
                245                 250                 255     


Arg Ala Ser Phe Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly 
            260                 265                 270         


Arg Gly Arg Gly Gly Thr Arg Thr His Phe Asp Tyr Gln Phe Gly Tyr 
        275                 280                 285             


Arg Lys Phe Asp Gly Val Glu Gly Pro Arg Thr Pro Lys Tyr Met Asn 
    290                 295                 300                 


Asn Ile Thr Tyr Tyr Phe Asp Asn Val Ser Ser Thr Glu Leu Tyr Ser 
305                 310                 315                 320 


Val Asp Gln Glu Leu Leu Lys Asp Tyr Ile Lys Arg Gln Ile Glu Tyr 
                325                 330                 335     


Tyr Phe Ser Val Asp Asn Leu Glu Arg Asp Phe Phe Leu Arg Arg Lys 
            340                 345                 350         


Met Asp Ala Asp Gly Phe Leu Pro Ile Thr Leu Ile Ala Ser Phe His 
        355                 360                 365             


Arg Val Gln Ala Leu Thr Thr Asp Ile Ser Leu Ile Phe Ala Ala Leu 
    370                 375                 380                 


Lys Asp Ser Lys Val Val Glu Ile Val Asp Glu Lys Val Arg Arg Arg 
385                 390                 395                 400 


Glu Glu Pro Glu Lys Trp Pro Leu Pro Pro Ile Val Asp Tyr Ser Gln 
                405                 410                 415     


Thr Asp Phe Ser Gln Leu Leu Asn Cys Pro Glu Phe Val Pro Arg Gln 
            420                 425                 430         


His Tyr Gln Lys Glu Thr Glu Ser Ala Pro Gly Ser Pro Arg Ala Val 
        435                 440                 445             


Thr Pro Val Pro Thr Lys Thr Glu Glu Val Ser Asn Leu Lys Thr Leu 
    450                 455                 460                 


Pro Lys Gly Leu Ser Ala Ser Leu Pro Asp Leu Asp Ser Glu Asn Trp 
465                 470                 475                 480 


Ile Glu Val Lys Lys Arg Pro Arg Pro Ser Pro Ala Arg Pro Lys Lys 
                485                 490                 495     


Ser Glu Glu Ser Arg Phe Ser His Leu Thr Ser Leu Pro Gln Gln Leu 
            500                 505                 510         


Pro Ser Gln Gln Leu Met Ser Lys Asp Gln Asp Glu Gln Glu Glu Leu 
        515                 520                 525             


Asp Phe Leu Phe Asp Glu Glu Met Glu Gln Met Asp Gly Arg Lys Asn 
    530                 535                 540                 


Thr Phe Thr Ala Trp Ser Asp Glu Glu Ser Asp Tyr Glu Ile Asp Asp 
545                 550                 555                 560 


Arg Asp Val Asn Lys Ile Leu Ile Val Thr Gln Thr Pro His Tyr Met 
                565                 570                 575     


Arg Arg His Pro Gly Gly Asp Arg Thr Gly Asn His Thr Ser Arg Ala 
            580                 585                 590         


Lys Met Ser Ala Glu Leu Ala Lys Val Ile Asn Asp Gly Leu Phe Tyr 
        595                 600                 605             


Tyr Glu Gln Asp Leu Trp Ala Glu Lys Phe Glu Pro Glu Tyr Ser Gln 
    610                 615                 620                 


Ile Lys Gln Glu Val Glu Asn Phe Lys Lys Val Asn Met Ile Ser Arg 
625                 630                 635                 640 


Glu Gln Phe Asp Thr Leu Thr Pro Glu Pro Pro Val Asp Pro Asn Gln 
                645                 650                 655     


Glu Val Pro Pro Gly Pro Pro Arg Phe Gln Gln Val Pro Thr Asp Ala 
            660                 665                 670         


Leu Ala Asn Lys Leu Phe Gly Ala Pro Glu Pro Ser Thr Ile Ala Arg 
        675                 680                 685             


Ser Leu Pro Thr Thr Val Pro Glu Ser Pro Asn Tyr Arg Asn Thr Arg 
    690                 695                 700                 


Thr Pro Arg Thr Pro Arg Thr Pro Gln Leu Lys Asp Ser Ser Gln Thr 
705                 710                 715                 720 


Ser Arg Phe Tyr Pro Val Val Lys Glu Gly Arg Thr Leu Asp Ala Lys 
                725                 730                 735     


Met Pro Arg Lys Arg Lys Thr Arg His Ser Ser Asn Pro Pro Leu Glu 
            740                 745                 750         


Ser His Val Gly Trp Val Met Asp Ser Arg Glu His Arg Pro Arg Thr 
        755                 760                 765             


Ala Ser Ile Ser Ser Ser Pro Ser Glu Gly Thr Pro Thr Val Gly Ser 
    770                 775                 780                 


Tyr Gly Cys Thr Pro Gln Ser Leu Pro Lys Phe Gln His Pro Ser His 
785                 790                 795                 800 


Glu Leu Leu Lys Glu Asn Gly Phe Thr Gln His Val Tyr His Lys Tyr 
                805                 810                 815     


Arg Arg Arg Cys Leu Asn Glu Arg Lys Arg Leu Gly Ile Gly Gln Ser 
            820                 825                 830         


Gln Glu Met Asn Thr Leu Phe Arg Phe Trp Ser Phe Phe Leu Arg Asp 
        835                 840                 845             


His Phe Asn Lys Lys Met Tyr Glu Glu Phe Lys Gln Leu Ala Leu Glu 
    850                 855                 860                 


Asp Ala Lys Glu Gly Tyr Arg Tyr Gly Leu Glu Cys Leu Phe Arg Tyr 
865                 870                 875                 880 


Tyr Ser Tyr Gly Leu Glu Lys Lys Phe Arg Leu Asp Ile Phe Lys Asp 
                885                 890                 895     


Phe Gln Glu Glu Thr Val Lys Asp Tyr Glu Ala Gly Gln Leu Tyr Gly 
            900                 905                 910         


Leu Glu Lys Phe Trp Ala Phe Leu Lys Tyr Ser Lys Ala Lys Asn Leu 
        915                 920                 925             


Asp Ile Asp Pro Lys Leu Gln Glu Tyr Leu Gly Lys Phe Arg Arg Leu 
    930                 935                 940                 


Glu Asp Phe Arg Val Asp Pro Pro Met Gly Glu Glu Gly Asn His Lys 
945                 950                 955                 960 


Arg His Ser Val Val Ala Gly Gly Gly Gly Gly Glu Gly Arg Lys Arg 
                965                 970                 975     


Cys Pro Ser Gln Ser Ser Ser Arg Pro Ala Ala Met Ile Ser Gln Pro 
            980                 985                 990         


Pro Thr Pro Pro Thr Gly Gln Pro  Val Arg Glu Asp Ala  Lys Trp Thr 
        995                 1000                 1005             


Ser Gln  His Ser Asn Thr Gln  Thr Leu Gly Lys 
    1010                 1015                 


