               SEQUENCE LISTING

<110> ethris GmbH

<120> Induction of osteogenesis by delivering BMP encoding RNA

<130> X2050 PCT S3

<150> EP 14 19 2539.6
<151> 2014-11-10

<160> 47

<170> BiSSAP 1.3

<210> 1
<211> 1191
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> 1..1191
<223> /transl_table=1

<400> 1
atg gtg gcc ggg acc cgc tgt ctt cta gcg ttg ctg ctt ccc cag gtc      48
Met Val Ala Gly Thr Arg Cys Leu Leu Ala Leu Leu Leu Pro Gln Val 
1               5                   10                  15      

ctc ctg ggc ggc gcg gct ggc ctc gtt ccg gag ctg ggc cgc agg aag      96
Leu Leu Gly Gly Ala Ala Gly Leu Val Pro Glu Leu Gly Arg Arg Lys 
            20                  25                  30          

ttc gcg gcg gcg tcg tcg ggc cgc ccc tca tcc cag ccc tct gac gag     144
Phe Ala Ala Ala Ser Ser Gly Arg Pro Ser Ser Gln Pro Ser Asp Glu 
        35                  40                  45              

gtc ctg agc gag ttc gag ttg cgg ctg ctc agc atg ttc ggc ctg aaa     192
Val Leu Ser Glu Phe Glu Leu Arg Leu Leu Ser Met Phe Gly Leu Lys 
    50                  55                  60                  

cag aga ccc acc ccc agc agg gac gcc gtg gtg ccc ccc tac atg cta     240
Gln Arg Pro Thr Pro Ser Arg Asp Ala Val Val Pro Pro Tyr Met Leu 
65                  70                  75                  80  

gac ctg tat cgc agg cac tca ggt cag ccg ggc tca ccc gcc cca gac     288
Asp Leu Tyr Arg Arg His Ser Gly Gln Pro Gly Ser Pro Ala Pro Asp 
                85                  90                  95      

cac cgg ttg gag agg gca gcc agc cga gcc aac act gtg cgc agc ttc     336
His Arg Leu Glu Arg Ala Ala Ser Arg Ala Asn Thr Val Arg Ser Phe 
            100                 105                 110         

cac cat gaa gaa tct ttg gaa gaa cta cca gaa acg agt ggg aaa aca     384
His His Glu Glu Ser Leu Glu Glu Leu Pro Glu Thr Ser Gly Lys Thr 
        115                 120                 125             

acc cgg aga ttc ttc ttt aat tta agt tct atc ccc acg gag gag ttt     432
Thr Arg Arg Phe Phe Phe Asn Leu Ser Ser Ile Pro Thr Glu Glu Phe 
    130                 135                 140                 

atc acc tca gca gag ctt cag gtt ttc cga gaa cag atg caa gat gct     480
Ile Thr Ser Ala Glu Leu Gln Val Phe Arg Glu Gln Met Gln Asp Ala 
145                 150                 155                 160 

tta gga aac aat agc agt ttc cat cac cga att aat att tat gaa atc     528
Leu Gly Asn Asn Ser Ser Phe His His Arg Ile Asn Ile Tyr Glu Ile 
                165                 170                 175     

ata aaa cct gca aca gcc aac tcg aaa ttc ccc gtg acc aga ctt ttg     576
Ile Lys Pro Ala Thr Ala Asn Ser Lys Phe Pro Val Thr Arg Leu Leu 
            180                 185                 190         

gac acc agg ttg gtg aat cag aat gca agc agg tgg gaa agt ttt gat     624
Asp Thr Arg Leu Val Asn Gln Asn Ala Ser Arg Trp Glu Ser Phe Asp 
        195                 200                 205             

gtc acc ccc gct gtg atg cgg tgg act gca cag gga cac gcc aac cat     672
Val Thr Pro Ala Val Met Arg Trp Thr Ala Gln Gly His Ala Asn His 
    210                 215                 220                 

gga ttc gtg gtg gaa gtg gcc cac ttg gag gag aaa caa ggt gtc tcc     720
Gly Phe Val Val Glu Val Ala His Leu Glu Glu Lys Gln Gly Val Ser 
225                 230                 235                 240 

aag aga cat gtt agg ata agc agg tct ttg cac caa gat gaa cac agc     768
Lys Arg His Val Arg Ile Ser Arg Ser Leu His Gln Asp Glu His Ser 
                245                 250                 255     

tgg tca cag ata agg cca ttg cta gta act ttt ggc cat gat gga aaa     816
Trp Ser Gln Ile Arg Pro Leu Leu Val Thr Phe Gly His Asp Gly Lys 
            260                 265                 270         

ggg cat cct ctc cac aaa aga gaa aaa cgt caa gcc aaa cac aaa cag     864
Gly His Pro Leu His Lys Arg Glu Lys Arg Gln Ala Lys His Lys Gln 
        275                 280                 285             

cgg aaa cgc ctt aag tcc agc tgt aag aga cac cct ttg tac gtg gac     912
Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp 
    290                 295                 300                 

ttc agt gac gtg ggg tgg aat gac tgg att gtg gct ccc ccg ggg tat     960
Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr 
305                 310                 315                 320 

cac gcc ttt tac tgc cac gga gaa tgc cct ttt cct ctg gct gat cat    1008
His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His 
                325                 330                 335     

ctg aac tcc act aat cat gcc att gtt cag acg ttg gtc aac tct gtt    1056
Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val 
            340                 345                 350         

aac tct aag att cct aag gca tgc tgt gtc ccg aca gaa ctc agt gct    1104
Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala 
        355                 360                 365             

atc tcg atg ctg tac ctt gac gag aat gaa aag gtt gta tta aag aac    1152
Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn 
    370                 375                 380                 

tat cag gac atg gtt gtg gag ggt tgt ggg tgt cgc tag                1191
Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg     
385                 390                 395         

<210> 2
<211> 1296
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> 1..1296
<223> /transl_table=1

<400> 2
atg cac gtg cgc tca ctg cga gct gcg gcg ccg cac agc ttc gtg gcg      48
Met His Val Arg Ser Leu Arg Ala Ala Ala Pro His Ser Phe Val Ala 
1               5                   10                  15      

ctc tgg gca ccc ctg ttc ctg ctg cgc tcc gcc ctg gcc gac ttc agc      96
Leu Trp Ala Pro Leu Phe Leu Leu Arg Ser Ala Leu Ala Asp Phe Ser 
            20                  25                  30          

ctg gac aac gag gtg cac tcg agc ttc atc cac cgg cgc ctc cgc agc     144
Leu Asp Asn Glu Val His Ser Ser Phe Ile His Arg Arg Leu Arg Ser 
        35                  40                  45              

cag gag cgg cgg gag atg cag cgc gag atc ctc tcc att ttg ggc ttg     192
Gln Glu Arg Arg Glu Met Gln Arg Glu Ile Leu Ser Ile Leu Gly Leu 
    50                  55                  60                  

ccc cac cgc ccg cgc ccg cac ctc cag ggc aag cac aac tcg gca ccc     240
Pro His Arg Pro Arg Pro His Leu Gln Gly Lys His Asn Ser Ala Pro 
65                  70                  75                  80  

atg ttc atg ctg gac ctg tac aac gcc atg gcg gtg gag gag ggc ggc     288
Met Phe Met Leu Asp Leu Tyr Asn Ala Met Ala Val Glu Glu Gly Gly 
                85                  90                  95      

ggg ccc ggc ggc cag ggc ttc tcc tac ccc tac aag gcc gtc ttc agt     336
Gly Pro Gly Gly Gln Gly Phe Ser Tyr Pro Tyr Lys Ala Val Phe Ser 
            100                 105                 110         

acc cag ggc ccc cct ctg gcc agc ctg caa gat agc cat ttc ctc acc     384
Thr Gln Gly Pro Pro Leu Ala Ser Leu Gln Asp Ser His Phe Leu Thr 
        115                 120                 125             

gac gcc gac atg gtc atg agc ttc gtc aac ctc gtg gaa cat gac aag     432
Asp Ala Asp Met Val Met Ser Phe Val Asn Leu Val Glu His Asp Lys 
    130                 135                 140                 

gaa ttc ttc cac cca cgc tac cac cat cga gag ttc cgg ttt gat ctt     480
Glu Phe Phe His Pro Arg Tyr His His Arg Glu Phe Arg Phe Asp Leu 
145                 150                 155                 160 

tcc aag atc cca gaa ggg gaa gct gtc acg gca gcc gaa ttc cgg atc     528
Ser Lys Ile Pro Glu Gly Glu Ala Val Thr Ala Ala Glu Phe Arg Ile 
                165                 170                 175     

tac aag gac tac atc cgg gaa cgc ttc gac aat gag acg ttc cgg atc     576
Tyr Lys Asp Tyr Ile Arg Glu Arg Phe Asp Asn Glu Thr Phe Arg Ile 
            180                 185                 190         

agc gtt tat cag gtg ctc cag gag cac ttg ggc agg gaa tcg gat ctc     624
Ser Val Tyr Gln Val Leu Gln Glu His Leu Gly Arg Glu Ser Asp Leu 
        195                 200                 205             

ttc ctg ctc gac agc cgt acc ctc tgg gcc tcg gag gag ggc tgg ctg     672
Phe Leu Leu Asp Ser Arg Thr Leu Trp Ala Ser Glu Glu Gly Trp Leu 
    210                 215                 220                 

gtg ttt gac atc aca gcc acc agc aac cac tgg gtg gtc aat ccg cgg     720
Val Phe Asp Ile Thr Ala Thr Ser Asn His Trp Val Val Asn Pro Arg 
225                 230                 235                 240 

cac aac ctg ggc ctg cag ctc tcg gtg gag acg ctg gat ggg cag agc     768
His Asn Leu Gly Leu Gln Leu Ser Val Glu Thr Leu Asp Gly Gln Ser 
                245                 250                 255     

atc aac ccc aag ttg gcg ggc ctg att ggg cgg cac ggg ccc cag aac     816
Ile Asn Pro Lys Leu Ala Gly Leu Ile Gly Arg His Gly Pro Gln Asn 
            260                 265                 270         

aag cag ccc ttc atg gtg gct ttc ttc aag gcc acg gag gtc cac ttc     864
Lys Gln Pro Phe Met Val Ala Phe Phe Lys Ala Thr Glu Val His Phe 
        275                 280                 285             

cgc agc atc cgg tcc acg ggg agc aaa cag cgc agc cag aac cgc tcc     912
Arg Ser Ile Arg Ser Thr Gly Ser Lys Gln Arg Ser Gln Asn Arg Ser 
    290                 295                 300                 

aag acg ccc aag aac cag gaa gcc ctg cgg atg gcc aac gtg gca gag     960
Lys Thr Pro Lys Asn Gln Glu Ala Leu Arg Met Ala Asn Val Ala Glu 
305                 310                 315                 320 

aac agc agc agc gac cag agg cag gcc tgt aag aag cac gag ctg tat    1008
Asn Ser Ser Ser Asp Gln Arg Gln Ala Cys Lys Lys His Glu Leu Tyr 
                325                 330                 335     

gtc agc ttc cga gac ctg ggc tgg cag gac tgg atc atc gcg cct gaa    1056
Val Ser Phe Arg Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala Pro Glu 
            340                 345                 350         

ggc tac gcc gcc tac tac tgt gag ggg gag tgt gcc ttc cct ctg aac    1104
Gly Tyr Ala Ala Tyr Tyr Cys Glu Gly Glu Cys Ala Phe Pro Leu Asn 
        355                 360                 365             

tcc tac atg aac gcc acc aac cac gcc atc gtg cag acg ctg gtc cac    1152
Ser Tyr Met Asn Ala Thr Asn His Ala Ile Val Gln Thr Leu Val His 
    370                 375                 380                 

ttc atc aac ccg gaa acg gtg ccc aag ccc tgc tgt gcg ccc acg cag    1200
Phe Ile Asn Pro Glu Thr Val Pro Lys Pro Cys Cys Ala Pro Thr Gln 
385                 390                 395                 400 

ctc aat gcc atc tcc gtc ctc tac ttc gat gac agc tcc aac gtc atc    1248
Leu Asn Ala Ile Ser Val Leu Tyr Phe Asp Asp Ser Ser Asn Val Ile 
                405                 410                 415     

ctg aag aaa tac aga aac atg gtg gtc cgg gcc tgt ggc tgc cac tag    1296
Leu Lys Lys Tyr Arg Asn Met Val Val Arg Ala Cys Gly Cys His     
            420                 425                 430         

<210> 3
<211> 396
<212> PRT
<213> Homo sapiens

<220> 
<223> [CDS]:1..1191 from SEQ ID NO 1

<400> 3
Met Val Ala Gly Thr Arg Cys Leu Leu Ala Leu Leu Leu Pro Gln Val 
1               5                   10                  15      
Leu Leu Gly Gly Ala Ala Gly Leu Val Pro Glu Leu Gly Arg Arg Lys 
            20                  25                  30          
Phe Ala Ala Ala Ser Ser Gly Arg Pro Ser Ser Gln Pro Ser Asp Glu 
        35                  40                  45              
Val Leu Ser Glu Phe Glu Leu Arg Leu Leu Ser Met Phe Gly Leu Lys 
    50                  55                  60                  
Gln Arg Pro Thr Pro Ser Arg Asp Ala Val Val Pro Pro Tyr Met Leu 
65                  70                  75                  80  
Asp Leu Tyr Arg Arg His Ser Gly Gln Pro Gly Ser Pro Ala Pro Asp 
                85                  90                  95      
His Arg Leu Glu Arg Ala Ala Ser Arg Ala Asn Thr Val Arg Ser Phe 
            100                 105                 110         
His His Glu Glu Ser Leu Glu Glu Leu Pro Glu Thr Ser Gly Lys Thr 
        115                 120                 125             
Thr Arg Arg Phe Phe Phe Asn Leu Ser Ser Ile Pro Thr Glu Glu Phe 
    130                 135                 140                 
Ile Thr Ser Ala Glu Leu Gln Val Phe Arg Glu Gln Met Gln Asp Ala 
145                 150                 155                 160 
Leu Gly Asn Asn Ser Ser Phe His His Arg Ile Asn Ile Tyr Glu Ile 
                165                 170                 175     
Ile Lys Pro Ala Thr Ala Asn Ser Lys Phe Pro Val Thr Arg Leu Leu 
            180                 185                 190         
Asp Thr Arg Leu Val Asn Gln Asn Ala Ser Arg Trp Glu Ser Phe Asp 
        195                 200                 205             
Val Thr Pro Ala Val Met Arg Trp Thr Ala Gln Gly His Ala Asn His 
    210                 215                 220                 
Gly Phe Val Val Glu Val Ala His Leu Glu Glu Lys Gln Gly Val Ser 
225                 230                 235                 240 
Lys Arg His Val Arg Ile Ser Arg Ser Leu His Gln Asp Glu His Ser 
                245                 250                 255     
Trp Ser Gln Ile Arg Pro Leu Leu Val Thr Phe Gly His Asp Gly Lys 
            260                 265                 270         
Gly His Pro Leu His Lys Arg Glu Lys Arg Gln Ala Lys His Lys Gln 
        275                 280                 285             
Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp 
    290                 295                 300                 
Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr 
305                 310                 315                 320 
His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His 
                325                 330                 335     
Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val 
            340                 345                 350         
Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala 
        355                 360                 365             
Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn 
    370                 375                 380                 
Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
385                 390                 395     

<210> 4
<211> 431
<212> PRT
<213> Homo sapiens

<220> 
<223> [CDS]:1..1296 from SEQ ID NO 2

<400> 4
Met His Val Arg Ser Leu Arg Ala Ala Ala Pro His Ser Phe Val Ala 
1               5                   10                  15      
Leu Trp Ala Pro Leu Phe Leu Leu Arg Ser Ala Leu Ala Asp Phe Ser 
            20                  25                  30          
Leu Asp Asn Glu Val His Ser Ser Phe Ile His Arg Arg Leu Arg Ser 
        35                  40                  45              
Gln Glu Arg Arg Glu Met Gln Arg Glu Ile Leu Ser Ile Leu Gly Leu 
    50                  55                  60                  
Pro His Arg Pro Arg Pro His Leu Gln Gly Lys His Asn Ser Ala Pro 
65                  70                  75                  80  
Met Phe Met Leu Asp Leu Tyr Asn Ala Met Ala Val Glu Glu Gly Gly 
                85                  90                  95      
Gly Pro Gly Gly Gln Gly Phe Ser Tyr Pro Tyr Lys Ala Val Phe Ser 
            100                 105                 110         
Thr Gln Gly Pro Pro Leu Ala Ser Leu Gln Asp Ser His Phe Leu Thr 
        115                 120                 125             
Asp Ala Asp Met Val Met Ser Phe Val Asn Leu Val Glu His Asp Lys 
    130                 135                 140                 
Glu Phe Phe His Pro Arg Tyr His His Arg Glu Phe Arg Phe Asp Leu 
145                 150                 155                 160 
Ser Lys Ile Pro Glu Gly Glu Ala Val Thr Ala Ala Glu Phe Arg Ile 
                165                 170                 175     
Tyr Lys Asp Tyr Ile Arg Glu Arg Phe Asp Asn Glu Thr Phe Arg Ile 
            180                 185                 190         
Ser Val Tyr Gln Val Leu Gln Glu His Leu Gly Arg Glu Ser Asp Leu 
        195                 200                 205             
Phe Leu Leu Asp Ser Arg Thr Leu Trp Ala Ser Glu Glu Gly Trp Leu 
    210                 215                 220                 
Val Phe Asp Ile Thr Ala Thr Ser Asn His Trp Val Val Asn Pro Arg 
225                 230                 235                 240 
His Asn Leu Gly Leu Gln Leu Ser Val Glu Thr Leu Asp Gly Gln Ser 
                245                 250                 255     
Ile Asn Pro Lys Leu Ala Gly Leu Ile Gly Arg His Gly Pro Gln Asn 
            260                 265                 270         
Lys Gln Pro Phe Met Val Ala Phe Phe Lys Ala Thr Glu Val His Phe 
        275                 280                 285             
Arg Ser Ile Arg Ser Thr Gly Ser Lys Gln Arg Ser Gln Asn Arg Ser 
    290                 295                 300                 
Lys Thr Pro Lys Asn Gln Glu Ala Leu Arg Met Ala Asn Val Ala Glu 
305                 310                 315                 320 
Asn Ser Ser Ser Asp Gln Arg Gln Ala Cys Lys Lys His Glu Leu Tyr 
                325                 330                 335     
Val Ser Phe Arg Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala Pro Glu 
            340                 345                 350         
Gly Tyr Ala Ala Tyr Tyr Cys Glu Gly Glu Cys Ala Phe Pro Leu Asn 
        355                 360                 365             
Ser Tyr Met Asn Ala Thr Asn His Ala Ile Val Gln Thr Leu Val His 
    370                 375                 380                 
Phe Ile Asn Pro Glu Thr Val Pro Lys Pro Cys Cys Ala Pro Thr Gln 
385                 390                 395                 400 
Leu Asn Ala Ile Ser Val Leu Tyr Phe Asp Asp Ser Ser Asn Val Ile 
                405                 410                 415     
Leu Lys Lys Tyr Arg Asn Met Val Val Arg Ala Cys Gly Cys His 
            420                 425                 430     

<210> 5
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> forward primer

<400> 5
ccgtgtcagc aaaacttctt t                                              21


<210> 6
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> reverse primer

<400> 6
gctcacgtcg ctcatcttg                                                 19


<210> 7
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> forward primer

<400> 7
tggaacactg ggtcccata                                                 19


<210> 8
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> reverse primer

<400> 8
gacctggtct tccctccaa                                                 19


<210> 9
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> forward primer

<400> 9
cccaactgtc aggagctaga g                                              21


<210> 10
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> reverse primer

<400> 10
gatgtggcgg ctgtgaat                                                  18


<210> 11
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> forward primer

<400> 11
tgcttgaaga cctatgtggg ta                                             22


<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> reverse primer

<400> 12
aaaggcagca tttggggtat                                                20


<210> 13
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> forward primer

<400> 13
acggcagctt cagctttg                                                  18


<210> 14
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> reverse primer

<400> 14
gaggcagaga gagggaacag                                                20


<210> 15
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> forward primer

<400> 15
atcgacagtc aggcgagttc                                                20


<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> reverse primer

<400> 16
gctgtgaaac tcgtggctct                                                20


<210> 17
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> forward primer

<400> 17
ctgatgagca gggcgagt                                                  18


<210> 18
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> reverse primer

<400> 18
tccgagaagt tcttaagcct ca                                             22


<210> 19
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> forward primer

<400> 19
ccccctacat gctagacctg t                                              21


<210> 20
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> reverse primer

<400> 20
cactcgtttc tggtagttct tcc                                            23


<210> 21
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> forward primer

<400> 21
tgcctaggcg catttcaggt gc                                             22


<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> reverse primer

<400> 22
tgaggtgact ggcggggtgt                                                20


<210> 23
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> forward primer

<400> 23
acgtggctaa gaatgtcatc                                                20


<210> 24
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> reverse primer

<400> 24
ctggtaggcg atgtcctta                                                 19


<210> 25
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> forward primer

<400> 25
cagccgcttc acctacagc                                                 19


<210> 26
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> reverse primer

<400> 26
ttttgtattc aatcactgtc ttgcc                                          25


<210> 27
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> forward primer

<400> 27
gagggcgagg acgaggctta                                                20


<210> 28
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> reverse primer

<400> 28
tctaacagag gcaaaactga gcacc                                          25


<210> 29
<211> 1674
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence of uncapped hBmp2 mRNA when the vector is linearized
      with XbaI

<400> 29
gagaataact tgcgcacccc actttgcgcc ggtgcctttg ccccagcgga gcctgcttcg      60

ccatctccga gccccaccgc ccctccactc ctcggccttg cccgacactg agacgctgtt     120

cccagcgtga aaagagagac tgcgcggccg gcacccggga gaaggaggag gcaaagaaaa     180

ggaacggaca ttcggtcctt gcgccaggtc ctttgaccag agtttttcca tgtggacgct     240

ctttcaatgg acgtgtcccc gcgtgcttct tagacggact gcggtctcct aaaggtcggc     300

caccatggtc gccggcacca gatgtctgct ggctctgctg ctgcctcagg tgctgctggg     360

cggagctgcc ggactggtgc ctgagctggg cagaagaaag ttcgccgctg ccagctctgg     420

cagacccagc agccagcctt ccgacgaggt gctgagcgag ttcgagctgc ggctgctgag     480

catgttcggc ctgaagcaga ggcccacccc cagcagagat gccgtggtgc ccccctacat     540

gctggacctg tacagacggc acagcggaca gcctggaagc cctgcccctg accacagact     600

ggaaagagcc gccagccggg ccaacaccgt gcggagcttt caccacgagg aaagcctgga     660

agaactgccc gagacaagcg gcaagaccac ccggcggttc tttttcaacc tgtcctccat     720

ccccaccgaa gagttcatca ccagcgccga actccaggtg ttccgcgagc agatgcagga     780

cgccctgggc aacaacagct catttcacca ccggatcaac atctacgaga tcatcaagcc     840

cgccaccgcc aacagcaagt tccccgtgac ccggctgctg gacacccggc tggtcaacca     900

gaacgccagc agatgggaga gcttcgacgt gacccctgcc gtgatgagat ggaccgccca     960

gggccacgcc aaccacggct ttgtggtgga agtggcccac ctggaagaga agcagggcgt    1020

gtccaagcgg cacgtgcgga tcagcagaag cctgcaccag gacgagcaca gctggtccca    1080

gatccggccc ctgctggtca ccttcggcca cgatggcaag ggccaccccc tgcacaagag    1140

agagaagcgg caggccaagc acaagcagcg gaagcggctg aagtccagct gcaagcggca    1200

ccccctgtac gtggacttca gcgacgtggg ctggaacgac tggatcgtgg cccctcccgg    1260

ctaccacgcc ttctactgcc acggcgagtg ccccttcccc ctggccgacc acctgaacag    1320

caccaaccac gccatcgtgc agaccctggt caacagcgtg aactccaaga tccccaaggc    1380

ctgctgcgtg cccaccgagc tgagcgccat cagcatgctg tacctggacg agaacgagaa    1440

ggtggtgctg aagaactacc aggacatggt ggtggaaggc tgtggctgta gatgatacag    1500

caaaattaaa tacataaata tatatataga attctgcaga aaaaaaaaaa aaaaaaaaaa    1560

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    1620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaag cggccgctcg agtc          1674


<210> 30
<211> 1661
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence of uncapped hBmp2 mRNA when the vector is linearized
      with NotI

<400> 30
gagaataact tgcgcacccc actttgcgcc ggtgcctttg ccccagcgga gcctgcttcg      60

ccatctccga gccccaccgc ccctccactc ctcggccttg cccgacactg agacgctgtt     120

cccagcgtga aaagagagac tgcgcggccg gcacccggga gaaggaggag gcaaagaaaa     180

ggaacggaca ttcggtcctt gcgccaggtc ctttgaccag agtttttcca tgtggacgct     240

ctttcaatgg acgtgtcccc gcgtgcttct tagacggact gcggtctcct aaaggtcggc     300

caccatggtc gccggcacca gatgtctgct ggctctgctg ctgcctcagg tgctgctggg     360

cggagctgcc ggactggtgc ctgagctggg cagaagaaag ttcgccgctg ccagctctgg     420

cagacccagc agccagcctt ccgacgaggt gctgagcgag ttcgagctgc ggctgctgag     480

catgttcggc ctgaagcaga ggcccacccc cagcagagat gccgtggtgc ccccctacat     540

gctggacctg tacagacggc acagcggaca gcctggaagc cctgcccctg accacagact     600

ggaaagagcc gccagccggg ccaacaccgt gcggagcttt caccacgagg aaagcctgga     660

agaactgccc gagacaagcg gcaagaccac ccggcggttc tttttcaacc tgtcctccat     720

ccccaccgaa gagttcatca ccagcgccga actccaggtg ttccgcgagc agatgcagga     780

cgccctgggc aacaacagct catttcacca ccggatcaac atctacgaga tcatcaagcc     840

cgccaccgcc aacagcaagt tccccgtgac ccggctgctg gacacccggc tggtcaacca     900

gaacgccagc agatgggaga gcttcgacgt gacccctgcc gtgatgagat ggaccgccca     960

gggccacgcc aaccacggct ttgtggtgga agtggcccac ctggaagaga agcagggcgt    1020

gtccaagcgg cacgtgcgga tcagcagaag cctgcaccag gacgagcaca gctggtccca    1080

gatccggccc ctgctggtca ccttcggcca cgatggcaag ggccaccccc tgcacaagag    1140

agagaagcgg caggccaagc acaagcagcg gaagcggctg aagtccagct gcaagcggca    1200

ccccctgtac gtggacttca gcgacgtggg ctggaacgac tggatcgtgg cccctcccgg    1260

ctaccacgcc ttctactgcc acggcgagtg ccccttcccc ctggccgacc acctgaacag    1320

caccaaccac gccatcgtgc agaccctggt caacagcgtg aactccaaga tccccaaggc    1380

ctgctgcgtg cccaccgagc tgagcgccat cagcatgctg tacctggacg agaacgagaa    1440

ggtggtgctg aagaactacc aggacatggt ggtggaaggc tgtggctgta gatgatacag    1500

caaaattaaa tacataaata tatatataga attctgcaga aaaaaaaaaa aaaaaaaaaa    1560

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    1620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaag c                        1661


<210> 31
<211> 1489
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence of uncapped hBmp7 mRNA when the vector is linearized
      with NotI

<400> 31
gagacccaag ctggctagcg tttaaactta agcttggtac cgagctcgga tccgccacca      60

tgcacgtacg cagtcttagg gctgctgccc cacacagctt tgtggccctg tgggcacccc     120

tctttctgct taggtctgct cttgccgact tttcactgga caacgaggtc cattcctcat     180

ttatccaccg tcgactgaga agccaagaga ggcgggaaat gcagcgcgag attttgtcta     240

tcctgggatt gccccataga cctcgtcccc atctccaagg gaaacacaac tctgctccca     300

tgttcatgct ggatctgtac aatgccatgg cagtggagga aggtggtggc ccaggaggac     360

agggcttctc ctatccgtac aaggccgtct tttccaccca aggtccaccg ttggcgagtc     420

tccaggattc ccatttcctg accgatgcgg acatggtgat gtcattcgtg aacctggtgg     480

aacacgacaa agagttcttt caccccaggt atcaccacag agagttccgc ttcgacttga     540

gtaaaatccc tgagggagaa gccgttactg ccgccgagtt tcgcatttac aaggactaca     600

ttcgggagag gttcgataac gaaaccttcc ggatatccgt gtatcaggtg ctgcaagagc     660

atctggggag agagtccgat ctcttcctcc tggacagtag gacactgtgg gcgtctgagg     720

aaggctggct tgtgttcgac ataactgcca cgagcaatca ctgggttgta aacccaaggc     780

ataacctggg gcttcagctg tctgtcgaga cactggatgg gcagagcatc aatcccaaac     840

tggctgggtt gatcggacgc catggtccac agaacaaaca gcctttcatg gtagctttct     900

ttaaggccac agaagtgcac tttcggagta ttcggagcac tggcagcaaa cagagaagcc     960

agaatagatc caagacccct aagaatcagg aagccctgcg gatggcaaat gtggcggaga    1020

atagcagctc agatcagaga caggcttgca agaagcatga actgtatgtg tcttttcgag    1080

atctcggatg gcaggactgg attatcgcac cagagggcta tgctgcctac tattgcgaag    1140

gcgagtgcgc atttcctctg aacagctaca tgaacgcaac caatcatgcc attgtccaaa    1200

cactcgttca cttcatcaat ccggaaactg tgcctaaacc ctgttgtgca cctacgcagc    1260

tgaacgctat atctgttctg tactttgacg attcatccaa cgtcatcctc aagaagtacc    1320

gcaatatggt tgtccgagca tgcggctgtc actgagaatt cctgcagaaa aaaaaaaaaa    1380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaagc                1489


<210> 32
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> forward mouse primer

<400> 32
gtgccctgac tgaggctgtc                                                20


<210> 33
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> reverse mouse primer

<400> 33
ggatcatcgt gtcctgctca c                                              21


<210> 34
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> forward mouse primer

<400> 34
ccgggagcag tgtgagctta                                                20


<210> 35
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> reverse mouse primer

<400> 35
tagatgcgtt tgtaggcggt c                                              21


<210> 36
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> forward mouse primer

<400> 36
gcacagtcaa ggccgagaat                                                20


<210> 37
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> reverse mouse primer

<400> 37
gccttctcca tggtggtgaa                                                20


<210> 38
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> forward rat primer

<400> 38
ccgtgtcagc aaaacttctt t                                              21


<210> 39
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> reverse rat primer

<400> 39
gctcacgtcg ctcatcttg                                                 19


<210> 40
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> forward rat primer

<400> 40
cccaactgtc aggagctaga g                                              21


<210> 41
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> reverse rat primer

<400> 41
gatgtggcgg ctgtgaat                                                  18


<210> 42
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> forward rat primer

<400> 42
acggcagctt cagctttg                                                  18


<210> 43
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> reverse rat primer

<400> 43
gaggcagaga gagggaacag                                                20


<210> 44
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> forward rat primer

<400> 44
tggaacactg ggtcccata                                                 19


<210> 45
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> reverse rat primer

<400> 45
gacctggtct tccctccaa                                                 19


<210> 46
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> forward rat primer

<400> 46
ctgatgagca gggcgagt                                                  18


<210> 47
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> reverse rat primer

<400> 47
tccgagaagt tcttaagcct ca                                             22


