                         SEQUENCE LISTING

<110>  The Hospital for Sick Children
 
<120>  METHOD FOR TREATING A BRAIN TUMOUR

<130>  H8312976PCT

<140>  PCT CA2015/051185
<141>  2015-11-13

<150>  US 62/079,759
<151>  2014-11-14

<160>  5     

<170>  PatentIn version 3.3

<210>  1
<211>  1378
<212>  DNA
<213>  Homo sapiens

<400>  1
atggggaacc gcagcaccgc ggacgcggac gggctgctgg ctgggcgcgg gccggccgcg     60

ggggcatctg cgggggcatc tgcggggctg gctgggcagg gcgcggcggc gctggtgggg    120

ggcgtgctgc tcatcggcgc ggtgctcgcg gggaactcgc tcgtgtgcgt gagcgtggcc    180

accgagcgcg ccctgcagac gcccaccaac tccttcatcg tgagcctggc ggccgccgac    240

ctcctcctcg ctctcctggt gctgccgctc ttcgtctact ccgaggtcca gggtggcgcg    300

tggctgctga gcccccgcct gtgcgacgcc ctcatggcca tggacgtcat gctgtgcacc    360

gcctccatct tcaacctgtg cgccatcagc gtggacaggt tcgtggccgt ggccgtgccg    420

ctgcgctaca accggcaggg tgggagccgc cggcagctgc tgctcatcgg cgccacgtgg    480

ctgctgtccg cggcggtggc ggcgcccgta ctgtgcggcc tcaacgacgt gcgcggccgc    540

gaccccgccg tgtgccgcct ggaggaccgc gactacgtgg tctactcgtc cgtgtgctcc    600

ttcttcctac cctgcccgct catgctgctg ctctactggg ccacgttccg cggcctgcag    660

cgctgggagg tggcacgtcg cgccaagctg cacggccgcg cgccccgccg acccagcggc    720

cctggcccgc cttcccccac gccacccgcg ccccgcctcc cccaggaccc ctgcggcccc    780

gactgtgcgc cccccgcgcc cggccttccc cggggtccct gcggccccga ctgtgcgccc    840

gccgcgccca gcctccccca ggacccctgc ggccccgact gtgcgccccc cgcgcccggc    900

ctccccccgg acccctgcgg ctccaactgt gctccccccg acgccgtcag agccgccgcg    960

ctcccacccc agactccacc gcagacccgc aggaggcggc gtgccaagat caccggccgg   1020

gagcgcaagg ccatgagggt cctgccggtg gtggtcgggg ccttcctgct gtgctggacg   1080

cccttcttcg tggtgcacat cacgcaggcg ctgtgtcctg cctgctccgt gcccccgcgg   1140

ctggtcagcg ccgtcacctg gctgggctac gtcaacagcg ccctcaaccc cgtcatctac   1200

actgtcttca acgccgagtt ccgcaacgtc ttccgcaagg ccctgcgtgc ctgctgctga   1260

gccgggcacc cccggacgcc ccccggcctg atggccaggc ctcagggacc aaggagatgg   1320

ggagggcgct tttgtacgtt aattaaacaa attccttccc aaaaaaaaaa aaaaaaaa     1378


<210>  2
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Asn Arg Ser Thr Ala Asp Ala Asp Gly Leu Leu Ala Gly Arg 
1               5                   10                  15      


Gly Pro Ala Ala Gly Ala Ser Ala Gly Ala Ser Ala Gly Leu Ala Gly 
            20                  25                  30          


Gln Gly Ala Ala Ala Leu Val Gly Gly Val Leu Leu Ile Gly Ala Val 
        35                  40                  45              


Leu Ala Gly Asn Ser Leu Val Cys Val Ser Val Ala Thr Glu Arg Ala 
    50                  55                  60                  


Leu Gln Thr Pro Thr Asn Ser Phe Ile Val Ser Leu Ala Ala Ala Asp 
65                  70                  75                  80  


Leu Leu Leu Ala Leu Leu Val Leu Pro Leu Phe Val Tyr Ser Glu Val 
                85                  90                  95      


Gln Gly Gly Ala Trp Leu Leu Ser Pro Arg Leu Cys Asp Ala Leu Met 
            100                 105                 110         


Ala Met Asp Val Met Leu Cys Thr Ala Ser Ile Phe Asn Leu Cys Ala 
        115                 120                 125             


Ile Ser Val Asp Arg Phe Val Ala Val Ala Val Pro Leu Arg Tyr Asn 
    130                 135                 140                 


Arg Gln Gly Gly Ser Arg Arg Gln Leu Leu Leu Ile Gly Ala Thr Trp 
145                 150                 155                 160 


Leu Leu Ser Ala Ala Val Ala Ala Pro Val Leu Cys Gly Leu Asn Asp 
                165                 170                 175     


Val Arg Gly Arg Asp Pro Ala Val Cys Arg Leu Glu Asp Arg Asp Tyr 
            180                 185                 190         


Val Val Tyr Ser Ser Val Cys Ser Phe Phe Leu Pro Cys Pro Leu Met 
        195                 200                 205             


Leu Leu Leu Tyr Trp Ala Thr Phe Arg Gly Leu Gln Arg Trp Glu Val 
    210                 215                 220                 


Ala Arg Arg Ala Lys Leu His Gly Arg Ala Pro Arg Arg Pro Ser Gly 
225                 230                 235                 240 


Pro Gly Pro Pro Ser Pro Thr Pro Pro Ala Pro Arg Leu Pro Gln Asp 
                245                 250                 255     


Pro Cys Gly Pro Asp Cys Ala Pro Pro Ala Pro Gly Leu Pro Arg Gly 
            260                 265                 270         


Pro Cys Gly Pro Asp Cys Ala Pro Ala Ala Pro Ser Leu Pro Gln Asp 
        275                 280                 285             


Pro Cys Gly Pro Asp Cys Ala Pro Pro Ala Pro Gly Leu Pro Pro Asp 
    290                 295                 300                 


Pro Cys Gly Ser Asn Cys Ala Pro Pro Asp Ala Val Arg Ala Ala Ala 
305                 310                 315                 320 


Leu Pro Pro Gln Thr Pro Pro Gln Thr Arg Arg Arg Arg Arg Ala Lys 
                325                 330                 335     


Ile Thr Gly Arg Glu Arg Lys Ala Met Arg Val Leu Pro Val Val Val 
            340                 345                 350         


Gly Ala Phe Leu Leu Cys Trp Thr Pro Phe Phe Val Val His Ile Thr 
        355                 360                 365             


Gln Ala Leu Cys Pro Ala Cys Ser Val Pro Pro Arg Leu Val Ser Ala 
    370                 375                 380                 


Val Thr Trp Leu Gly Tyr Val Asn Ser Ala Leu Asn Pro Val Ile Tyr 
385                 390                 395                 400 


Thr Val Phe Asn Ala Glu Phe Arg Asn Val Phe Arg Lys Ala Leu Arg 
                405                 410                 415     


Ala Cys Cys 
            


<210>  3
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  sh-RNA

<400>  3
ttgaggccgc acagtacggg c                                               21


<210>  4
<211>  1366
<212>  DNA
<213>  Mus sp.

<400>  4
gcgcctcccg gagcgggttc agcagtggca ccatggggaa cagcagcgct actgaggacg     60

gtgggctgtt ggccgggcgt gggccagaat ccctggggac tggcgccggg cttgggggcg    120

cgggcgcggc ggcgctggtg gggggcgtgc tgctcatcgg cttggtgttg gcagggaact    180

cgctcgtgtg cgtgagcgtg gcctccgagc gcacgctgca gacacccacc aactacttca    240

tcgtgagcct ggctgctgcc gacctcctcc tcgcggtgct ggtgctgcct ctctttgtct    300

actccgaggt ccagggtggc gtgtggctcc tgagcccccg tctctgtgac acgctcatgg    360

ccatggacgt catgctgtgc accgcctcca tcttcaacct gtgcgccatc agcgtggaca    420

ggttcgtggc cgtgaccgtg ccgctgcgct acaaccagca gggtcagtgc cagctgctgc    480

tcatcgccgc cacgtggctg ctgtccgccg cggtggcttc gccagtggtg tgtggcctca    540

atgatgtgcc cggccgcgat ccggccgtgt gctgcctgga gaaccgagac tatgtggtct    600

actcgtccgt ctgctccttc ttcctgccct gtccgctcat gctactgctt tactgggcca    660

ctttccgcgg cctgcggcgc tgggaggcag cccggcacac caaacttcac agccgcgcgc    720

cgcgccgacc cagcggcccc ggcccgccgg tgtcggaccc tactcagggt cccttcttcc    780

cagactgccc acctccctta cccagcctcc ggacgagccc cagcgactcc agcaggccgg    840

agtcagagct ctctcagaga ccctgcagcc ccgggtgtct gctcgctgat gcagctctcc    900

cgcaacctcc tgagccgtct tcccgcagaa ggagaggcgc caagatcacg ggaagggagc    960

gcaaggcaat gagagtcctg ccggtggtag tcggggcctt cctggtgtgt tggacgcctt   1020

tcttcgtggt gcacatcacg cgggcgctgt gtccggcttg cttcgtgtct ccgcgcctgg   1080

tcagtgccgt cacctggcta ggctatgtca acagtgccct caaccccatc atctacacca   1140

tcttcaacgc ggagtttcga agtgtcttcc gcaagactct ccgtctccgc tgctgaaagg   1200

atgtcctgca gaggtcaagg agttccaaga ctgtgtgcag agtgcgctgg cgcgcattct   1260

ttcagtctga ttaaacgaaa tcttttctaa ccacttatga aggctggggg ttgggaaaaa   1320

gaaaagaaaa gaggaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                  1366


<210>  5
<211>  387
<212>  PRT
<213>  Mus sp.

<400>  5

Met Gly Asn Ser Ser Ala Thr Glu Asp Gly Gly Leu Leu Ala Gly Arg 
1               5                   10                  15      


Gly Pro Glu Ser Leu Gly Thr Gly Ala Gly Leu Gly Gly Ala Gly Ala 
            20                  25                  30          


Ala Ala Leu Val Gly Gly Val Leu Leu Ile Gly Leu Val Leu Ala Gly 
        35                  40                  45              


Asn Ser Leu Val Cys Val Ser Val Ala Ser Glu Arg Thr Leu Gln Thr 
    50                  55                  60                  


Pro Thr Asn Tyr Phe Ile Val Ser Leu Ala Ala Ala Asp Leu Leu Leu 
65                  70                  75                  80  


Ala Val Leu Val Leu Pro Leu Phe Val Tyr Ser Glu Val Gln Gly Gly 
                85                  90                  95      


Val Trp Leu Leu Ser Pro Arg Leu Cys Asp Thr Leu Met Ala Met Asp 
            100                 105                 110         


Val Met Leu Cys Thr Ala Ser Ile Phe Asn Leu Cys Ala Ile Ser Val 
        115                 120                 125             


Asp Arg Phe Val Ala Val Thr Val Pro Leu Arg Tyr Asn Gln Gln Gly 
    130                 135                 140                 


Gln Cys Gln Leu Leu Leu Ile Ala Ala Thr Trp Leu Leu Ser Ala Ala 
145                 150                 155                 160 


Val Ala Ser Pro Val Val Cys Gly Leu Asn Asp Val Pro Gly Arg Asp 
                165                 170                 175     


Pro Ala Val Cys Cys Leu Glu Asn Arg Asp Tyr Val Val Tyr Ser Ser 
            180                 185                 190         


Val Cys Ser Phe Phe Leu Pro Cys Pro Leu Met Leu Leu Leu Tyr Trp 
        195                 200                 205             


Ala Thr Phe Arg Gly Leu Arg Arg Trp Glu Ala Ala Arg His Thr Lys 
    210                 215                 220                 


Leu His Ser Arg Ala Pro Arg Arg Pro Ser Gly Pro Gly Pro Pro Val 
225                 230                 235                 240 


Ser Asp Pro Thr Gln Gly Pro Phe Phe Pro Asp Cys Pro Pro Pro Leu 
                245                 250                 255     


Pro Ser Leu Arg Thr Ser Pro Ser Asp Ser Ser Arg Pro Glu Ser Glu 
            260                 265                 270         


Leu Ser Gln Arg Pro Cys Ser Pro Gly Cys Leu Leu Ala Asp Ala Ala 
        275                 280                 285             


Leu Pro Gln Pro Pro Glu Pro Ser Ser Arg Arg Arg Arg Gly Ala Lys 
    290                 295                 300                 


Ile Thr Gly Arg Glu Arg Lys Ala Met Arg Val Leu Pro Val Val Val 
305                 310                 315                 320 


Gly Ala Phe Leu Val Cys Trp Thr Pro Phe Phe Val Val His Ile Thr 
                325                 330                 335     


Arg Ala Leu Cys Pro Ala Cys Phe Val Ser Pro Arg Leu Val Ser Ala 
            340                 345                 350         


Val Thr Trp Leu Gly Tyr Val Asn Ser Ala Leu Asn Pro Ile Ile Tyr 
        355                 360                 365             


Thr Ile Phe Asn Ala Glu Phe Arg Ser Val Phe Arg Lys Thr Leu Arg 
    370                 375                 380                 


Leu Arg Cys 
385         


