                         SEQUENCE LISTING

<110>  DAVILA, Eduardo
 
<120>  CD8a AND T CELL RECEPTOR VARIANTS AND METHODS OF USING SAME IN 
       MODULATING IMMUNE CELL RESPONSES

<130>  2015-1342A

<150>  US 62/130,092
<151>  2015-03-09

<150>  US 62/076,120
<151>  2014-11-06

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  705
<212>  DNA
<213>  Homo sapiens

<400>  1
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgagccagt tccgggtgtc gccgctggat cggacctgga acctgggcga gacagtggag      120

ctgaagtgcc aggtgctgct gtccaacccg acgtcgggct gctcgtggct cttccagccg      180

cgcggcgccg ccgccagtcc caccttcctc ctatacctct cccaaaacaa gcccaaggcg      240

gccgaggggc tggacaccca gcggttctcg ggcaagaggt tgggggacac cttcgtcctc      300

accctgagcg acttccgccg agagaacgag ggctactatt tctgctcggc cctgagcaac      360

tccatcatgt acttcagcca cttcgtgccg gtcttcctgc cagcgaagcc caccacgacg      420

ccagcgccgc gaccaccaac accggcgccc accatcgcgt cgcagcccct gtccctgcgc      480

ccagaggcgt gccggccagc ggcggggggc gcagtgcaca cgagggggct ggacttcgcc      540

tgtgatatct acatctgggc gcccttggcc gggacttgtg gggtccttct cctgtcactg      600

gttatcaccc tttactgcaa ccacaggaac cgaagacgtg tttgcaaatg tccccggcct      660

gtggtcaaat cgggagacaa gcccagcctt tcggcgagat acgtc                      705


<210>  2
<211>  609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CD8a without intracellular signaling domain

<400>  2
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgagccagt tccgggtgtc gccgctggat cggacctgga acctgggcga gacagtggag      120

ctgaagtgcc aggtgctgct gtccaacccg acgtcgggct gctcgtggct cttccagccg      180

cgcggcgccg ccgccagtcc caccttcctc ctatacctct cccaaaacaa gcccaaggcg      240

gccgaggggc tggacaccca gcggttctcg ggcaagaggt tgggggacac cttcgtcctc      300

accctgagcg acttccgccg agagaacgag ggctactatt tctgctcggc cctgagcaac      360

tccatcatgt acttcagcca cttcgtgccg gtcttcctgc cagcgaagcc caccacgacg      420

ccagcgccgc gaccaccaac accggcgccc accatcgcgt cgcagcccct gtccctgcgc      480

ccagaggcgt gccggccagc ggcggggggc gcagtgcaca cgagggggct ggacttcgcc      540

tgtgatatct acatctgggc gcccttggcc gggacttgtg gggtccttct cctgtcactg      600

gttatcacc                                                              609


<210>  3
<211>  1074
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CD8a-MyD88 where MyD88 lacks the TIR domain

<400>  3
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgagccagt tccgggtgtc gccgctggat cggacctgga acctgggcga gacagtggag      120

ctgaagtgcc aggtgctgct gtccaacccg acgtcgggct gctcgtggct cttccagccg      180

cgcggcgccg ccgccagtcc caccttcctc ctatacctct cccaaaacaa gcccaaggcg      240

gccgaggggc tggacaccca gcggttctcg ggcaagaggt tgggggacac cttcgtcctc      300

accctgagcg acttccgccg agagaacgag ggctactatt tctgctcggc cctgagcaac      360

tccatcatgt acttcagcca cttcgtgccg gtcttcctgc cagcgaagcc caccacgacg      420

ccagcgccgc gaccaccaac accggcgccc accatcgcgt cgcagcccct gtccctgcgc      480

ccagaggcgt gccggccagc ggcggggggc gcagtgcaca cgagggggct ggacttcgcc      540

tgtgatatct acatctgggc gcccttggcc gggacttgtg gggtccttct cctgtcactg      600

gttatcacca tggctgcagg aggtcccggc gcggggtctg cggccccggt ctcctccaca      660

tcctcccttc ccctggctgc tctcaacatg cgagtgcggc gccgcctgtc tctgttcttg      720

aacgtgcgga cacaggtggc ggccgactgg accgcgctgg cggaggagat ggactttgag      780

tacttggaga tccggcaact ggagacacaa gcggacccca ctggcaggct gctggacgcc      840

tggcagggac gccctggcgc ctctgtaggc cgactgctcg agctgcttac caagctgggc      900

cgcgacgacg tgctgctgga gctgggaccc agcattgagg aggattgcca aaagtatatc      960

ttgaagcagc agcaggagga ggctgagaag cctttacagg tggccgctgt agacagcagt     1020

gtcccacgga cagcagagct ggcgggcatc accacacttg atgaccccct gggg           1074


<210>  4
<211>  744
<212>  DNA
<213>  Mus musculus

<400>  4
atggcctcac cgttgacccg ctttctgtcg ctgaacctgc tgctgctggg tgagtcgatt       60

atcctgggga gtggagaagc taagccacag gcacccgaac tccgaatctt tccaaagaaa      120

atggacgccg aacttggtca gaaggtggac ctggtatgtg aagtgttggg gtccgtttcg      180

caaggatgct cttggctctt ccagaactcc agctccaaac tcccccagcc caccttcgtt      240

gtctatatgg cttcatccca caacaagata acgtgggacg agaagctgaa ttcgtcgaaa      300

ctgttttctg ccatgaggga cacgaataat aagtacgttc tcaccctgaa caagttcagc      360

aaggaaaacg aaggctacta tttctgctca gtcatcagca actcggtgat gtacttcagt      420

tctgtcgtgc cagtccttca gaaagtgaac tctactacta ccaagccagt gctgcgaact      480

ccctcacctg tgcaccctac cgggacatct cagccccaga gaccagaaga ttgtcggccc      540

cgtggctcag tgaaggggac cggattggac ttcgcctgtg atatttacat ctgggcaccc      600

ttggccggaa tctgcgtggc ccttctgctg tccttgatca tcactctcat ctgctaccac      660

aggagccgaa agcgtgtttg caaatgtccc aggccgctag tcagacagga aggcaagccc      720

agaccttcag agaaaattgt gtaa                                             744


<210>  5
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse CD8a without the intracellular signaling domain

<400>  5
atggcctcac cgttgacccg ctttctgtcg ctgaacctgc tgctgctggg tgagtcgatt       60

atcctgggga gtggagaagc taagccacag gcacccgaac tccgaatctt tccaaagaaa      120

atggacgccg aacttggtca gaaggtggac ctggtatgtg aagtgttggg gtccgtttcg      180

caaggatgct cttggctctt ccagaactcc agctccaaac tcccccagcc caccttcgtt      240

gtctatatgg cttcatccca caacaagata acgtgggacg agaagctgaa ttcgtcgaaa      300

ctgttttctg ccatgaggga cacgaataat aagtacgttc tcaccctgaa caagttcagc      360

aaggaaaacg aaggctacta tttctgctca gtcatcagca actcggtgat gtacttcagt      420

tctgtcgtgc cagtccttca gaaagtgaac tctactacta ccaagccagt gctgcgaact      480

ccctcacctg tgcaccctac cgggacatct cagccccaga gaccagaaga ttgtcggccc      540

cgtggctcag tgaaggggac cggattggac ttcgcctgtg atatttacat ctgggcaccc      600

ttggccggaa tctgcgtggc ccttctgctg tccttgatca tcactctcat c               651


<210>  6
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse CD8a-human MyD88 where MyD88 lacks TIR domain

<400>  6
atggcctcac cgttgacccg ctttctgtcg ctgaacctgc tgctgctggg tgagtcgatt       60

atcctgggga gtggagaagc taagccacag gcacccgaac tccgaatctt tccaaagaaa      120

atggacgccg aacttggtca gaaggtggac ctggtatgtg aagtgttggg gtccgtttcg      180

caaggatgct cttggctctt ccagaactcc agctccaaac tcccccagcc caccttcgtt      240

gtctatatgg cttcatccca caacaagata acgtgggacg agaagctgaa ttcgtcgaaa      300

ctgttttctg ccatgaggga cacgaataat aagtacgttc tcaccctgaa caagttcagc      360

aaggaaaacg aaggctacta tttctgctca gtcatcagca actcggtgat gtacttcagt      420

tctgtcgtgc cagtccttca gaaagtgaac tctactacta ccaagccagt gctgcgaact      480

ccctcacctg tgcaccctac cgggacatct cagccccaga gaccagaaga ttgtcggccc      540

cgtggctcag tgaaggggac cggattggac ttcgcctgtg atatttacat ctgggcaccc      600

ttggccggaa tctgcgtggc ccttctgctg tccttgatca tcactctcat catggctgca      660

ggaggtcccg gcgcggggtc tgcggccccg gtctcctcca catcctccct tcccctggct      720

gctctcaaca tgcgagtgcg gcgccgcctg tctctgttct tgaacgtgcg gacacaggtg      780

gcggccgact ggaccgcgct ggcggaggag atggactttg agtacttgga gatccggcaa      840

ctggagacac aagcggaccc cactggcagg ctgctggacg cctggcaggg acgccctggc      900

gcctctgtag gccgactgct cgagctgctt accaagctgg gccgcgacga cgtgctgctg      960

gagctgggac ccagcattga ggaggattgc caaaagtata tcttgaagca gcagcaggag     1020

gaggctgaga agcctttaca ggtggccgct gtagacagca gtgtcccacg gacagcagag     1080

ctggcgggca tcaccacact tgatgacccc ctgggg                               1116


<210>  7
<211>  715
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CD8a TM-MyD88

<400>  7
attcgtgccg gtcttcctgc cagcgaagcc caccacgacg ccagcgccgc gaccaccaac       60

accggcgccc accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc      120

ggcggggggc gcagtgcaca cgagggggct ggacttcgcc tgtgatatct acatctgggc      180

gcccttggcc gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa      240

ccacaggaac atggctgcag gaggtcccgg cgcggggtct gcggccccgg tctcctccac      300

atcctccctt cccctggctg ctctcaacat gcgagtgcgg cgccgcctgt ctctgttctt      360

gaacgtgcgg acacaggtgg cggccgactg gaccgcgctg gcggaggaga tggactttga      420

gtacttggag atccggcaac tggagacaca agcggacccc actggcaggc tgctggacgc      480

ctggcaggga cgccctggcg cctctgtagg ccgactgctc gagctgctta ccaagctggg      540

ccgcgacgac gtgctgctgg agctgggacc cagcattgag gaggattgcc aaaagtatat      600

cttgaagcag cagcaggagg aggctgagaa gcctttacag gtggccgctg tagacagcag      660

tgtcccacgg acagcagagc tggcgggcat caccacactt gatgaccccc tgggg           715


<210>  8
<211>  1254
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse CD8a-human CD28-human 41BB-human CD3zeta

<400>  8
atggcctcac cgttgacccg ctttctgtcg ctgaacctgc tgctgctggg tgagtcgatt       60

atcctgggga gtggagaagc taagccacag gcacccgaac tccgaatctt tccaaagaaa      120

atggacgccg aacttggtca gaaggtggac ctggtatgtg aagtgttggg gtccgtttcg      180

caaggatgct cttggctctt ccagaactcc agctccaaac tcccccagcc caccttcgtt      240

gtctatatgg cttcatccca caacaagata acgtgggacg agaagctgaa ttcgtcgaaa      300

ctgttttctg ccatgaggga cacgaataat aagtacgttc tcaccctgaa caagttcagc      360

aaggaaaacg aaggctacta tttctgctca gtcatcagca actcggtgat gtacttcagt      420

tctgtcgtgc cagtccttca gaaagtgaac tctactacta ccaagccagt gctgcgaact      480

ccctcacctg tgcaccctac cgggacatct cagccccaga gaccagaaga ttgtcggccc      540

cgtggctcag tgaaggggac cggattggac ttcgcctgtg atatttacat ctgggcaccc      600

ttggccggaa tctgcgtggc ccttctgctg tccttgatca tcactctcat caggagtaag      660

aggagcaggc tcctgcacag tgactacatg aacatgactc cccgccgccc cgggcccacc      720

cgcaagcatt accagcccta tgccccacca cgcgacttcg cagcctatcg ctcccgtttc      780

tctgttgtta aacggggcag aaagaagctc ctgtatatat tcaaacaacc atttatgaga      840

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa      900

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag      960

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1020

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1080

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1140

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1200

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1254


<210>  9
<211>  1722
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human CD4-MyD88 where MyD88 lacks the TIR domain

<400>  9
atgaaccggg gagtcccttt taggcacttg cttctggtgc tgcaactggc gctcctccca       60

gcagccactc agggaaagaa agtggtgctg ggcaaaaaag gggatacagt ggaactgacc      120

tgtacagctt cccagaagaa gagcatacaa ttccactgga aaaactccaa ccagataaag      180

attctgggaa atcagggctc cttcttaact aaaggtccat ccaagctgaa tgatcgcgct      240

gactcaagaa gaagcctttg ggaccaagga aactttcccc tgatcatcaa gaatcttaag      300

atagaagact cagatactta catctgtgaa gtggaggacc agaaggagga ggtgcaattg      360

ctagtgttcg gattgactgc caactctgac acccacctgc ttcaggggca gagcctgacc      420

ctgaccttgg agagcccccc tggtagtagc ccctcagtgc aatgtaggag tccaaggggt      480

aaaaacatac agggggggaa gaccctctcc gtgtctcagc tggagctcca ggatagtggc      540

acctggacat gcactgtctt gcagaaccag aagaaggtgg agttcaaaat agacatcgtg      600

gtgctagctt tccagaaggc ctccagcata gtctataaga aagaggggga acaggtggag      660

ttctccttcc cactcgcctt tacagttgaa aagctgacgg gcagtggcga gctgtggtgg      720

caggcggaga gggcttcctc ctccaagtct tggatcacct ttgacctgaa gaacaaggaa      780

gtgtctgtaa aacgggttac ccaggaccct aagctccaga tgggcaagaa gctcccgctc      840

cacctcaccc tgccccaggc cttgcctcag tatgctggct ctggaaacct caccctggcc      900

cttgaagcga aaacaggaaa gttgcatcag gaagtgaacc tggtggtgat gagagccact      960

cagctccaga aaaatttgac ctgtgaggtg tggggaccca cctcccctaa gctgatgctg     1020

agtttgaaac tggagaacaa ggaggcaaag gtctcgaagc gggagaaggc ggtgtgggtg     1080

ctgaaccctg aggcggggat gtggcagtgt ctgctgagtg actcgggaca ggtcctgctg     1140

gaatccaaca tcaaggttct gcccacatgg tccaccccgg tgcagccaat ggccctgatt     1200

gtgctggggg gcgtcgccgg cctcctgctt ttcattgggc taggcatctt cttcatggct     1260

gcaggaggtc ccggcgcggg gtctgcggcc ccggtctcct ccacatcctc ccttcccctg     1320

gctgctctca acatgcgagt gcggcgccgc ctgtctctgt tcttgaacgt gcggacacag     1380

gtggcggccg actggaccgc gctggcggag gagatggact ttgagtactt ggagatccgg     1440

caactggaga cacaagcgga ccccactggc aggctgctgg acgcctggca gggacgccct     1500

ggcgcctctg taggccgact gctcgagctg cttaccaagc tgggccgcga cgacgtgctg     1560

ctggagctgg gacccagcat tgaggaggat tgccaaaagt atatcttgaa gcagcagcag     1620

gaggaggctg agaagccttt acaggtggcc gctgtagaca gcagtgtccc acggacagca     1680

gagctggcgg gcatcaccac acttgatgac cccctggggt ga                        1722


<210>  10
<211>  1719
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse CD4-human MyD88 where MyD88 lacks the TIR domain

<400>  10
atgtgccgag ccatctctct taggcgcttg ctgctgctgc tgctgcagct gtcacaactc       60

ctagctgtca ctcaagggaa gacgctggtg ctggggaagg aaggggaatc agcagaactg      120

ccctgcgaga gttcccagaa gaagatcaca gtcttcacct ggaagttctc tgaccagagg      180

aagattctgg ggcagcatgg caaaggtgta ttaattagag gaggttcgcc ttcgcagttt      240

gatcgttttg attccaaaaa aggggcatgg gagaaaggat cgtttcctct catcatcaat      300

aaacttaaga tggaagactc tcagacttat atctgtgagc tggagaacag gaaagaggag      360

gtggagttgt gggtgttcaa agtgaccttc agtccgggta ccagcctgtt gcaagggcag      420

agcctgaccc tgaccttgga tagcaactct aaggtctcta accccttgac agagtgcaaa      480

cacaaaaagg gtaaagttgt cagtggttcc aaagttctct ccatgtccaa cctaagggtt      540

caggacagcg acttctggaa ctgcaccgtg accctggacc agaaaaagaa ctggttcggc      600

atgacactct cagtgctggg ttttcagagc acagctatca cggcctataa gagtgaggga      660

gagtcagcgg agttctcctt cccactcaac tttgcagagg aaaacgggtg gggagagctg      720

atgtggaagg cagagaagga ttctttcttc cagccctgga tctccttctc cataaagaac      780

aaagaggtgt ccgtacaaaa gtccaccaaa gacctcaagc tccagctgaa ggaaacgctc      840

ccactcaccc tcaagatacc ccaggtctcg cttcagtttg ctggttctgg caacctgact      900

ctgactctgg acaaagggac actgcatcag gaagtgaacc tggtggtgat gaaagtggct      960

cagctcaaca atactttgac ctgtgaggtg atgggaccta cctctcccaa gatgagactg     1020

accctgaagc aggagaacca ggaggccagg gtctctgagg agcagaaagt agttcaagtg     1080

gtggcccctg agacagggct gtggcagtgt ctactgagtg aaggtgataa ggtcaagatg     1140

gactccagga tccaggtttt atccagaggg gtgaaccaga cagtgttcct ggcttgcgtg     1200

ctgggtggct ccttcggctt tctgggtttc cttgggctct gcatcctctg catggctgca     1260

ggaggtcccg gcgcggggtc tgcggccccg gtctcctcca catcctccct tcccctggct     1320

gctctcaaca tgcgagtgcg gcgccgcctg tctctgttct tgaacgtgcg gacacaggtg     1380

gcggccgact ggaccgcgct ggcggaggag atggactttg agtacttgga gatccggcaa     1440

ctggagacac aagcggaccc cactggcagg ctgctggacg cctggcaggg acgccctggc     1500

gcctctgtag gccgactgct cgagctgctt accaagctgg gccgcgacga cgtgctgctg     1560

gagctgggac ccagcattga ggaggattgc caaaagtata tcttgaagca gcagcaggag     1620

gaggctgaga agcctttaca ggtggccgct gtagacagca gtgtcccacg gacagcagag     1680

ctggcgggca tcaccacact tgatgacccc ctggggtga                            1719


<210>  11
<211>  2285
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human DMF5 TCR-MyD88 where MyD88 lacks the TIR domain

<400>  11
ccgccatgat gaaatccttg agagttttac tagtgatcct gtggcttcag ttgagctggg       60

tttggagcca acagaaggag gtggagcaga attctggacc cctcagtgtt ccagagggag      120

ccattgcctc tctcaactgc acttacagtg accgaggttc ccagtccttc ttctggtaca      180

gacaatattc tgggaaaagc cctgagttga taatgttcat atactccaat ggtgacaaag      240

aagatggaag gtttacagca cagctcaata aagccagcca gtatgtttct ctgctcatca      300

gagactccca gcccagtgat tcagccacct acctctgtgc cgtgaacttc ggaggaggaa      360

agcttatctt cggacaggga acggagttat ctgtgaaacc caatatccag aaccctgacc      420

ctgccgtgta ccagctgaga gactctaaat ccagtgacaa gtctgtctgc ctattcaccg      480

attttgattc tcaaacaaat gtgtcacaaa gtaaggattc tgatgtgtat atcacagaca      540

aaactgtgct agacatgagg tctatggact tcaagagcaa cagtgctgtg gcctggagca      600

acaaatctga ctttgcatgt gcaaacgcct tcaacaacag cattattcca gaagacacct      660

tcttccccag cccagaaagt tcctgtgatg tcaagctggt cgagaaaagc tttgaaacag      720

atacgaacct aaactttcaa aacctgtcag tgattgggtt ccgaatcctc ctcctgaagg      780

tggccgggtt taatctgctc atgacgctgc ggctgtggtc cagcagagcc aaaagagagg      840

gcagaggaag tcttctaaca tgcggtgacg tggaggagaa tcccggccct atgagaatca      900

ggctcctgtg ctgtgtggcc ttttctctcc tgtgggcagg tccagtgatt gctgggatca      960

cccaggcacc aacatctcag atcctggcag caggacggcg catgacactg agatgtaccc     1020

aggatatgag acataatgcc atgtactggt atagacaaga tctaggactg gggctaaggc     1080

tcatccatta ttcaaatact gcaggtacca ctggcaaagg agaagtccct gatggttata     1140

gtgtctccag agcaaacaca gatgatttcc ccctcacgtt ggcgtctgct gtaccctctc     1200

agacatctgt gtacttctgt gccagcagcc taagtttcgg cactgaagct ttctttggac     1260

aaggcaccag actcacagtt gtagaggacc tgaacaaggt gttcccaccc gaggtcgctg     1320

tgtttgagcc atcagaagca gagatctccc acacccaaaa ggccacactg gtgtgcctgg     1380

ccacaggctt cttccctgac cacgtggagc tgagctggtg ggtgaatggg aaggaggtgc     1440

acagtggggt cagcacggac ccgcagcccc tcaaggagca gcccgccctc aatgactcca     1500

gatactgcct gagcagccgc ctgagggtct cggccacctt ctggcagaac ccccgcaacc     1560

acttccgctg tcaagtccag ttctacgggc tctcggagaa tgacgagtgg acccaggata     1620

gggccaaacc cgtcacccag atcgtcagcg ccgaggcctg gggtagagca gactgtggct     1680

ttacctcggt gtcctaccag caaggggtcc tgtctgccac catcctctat gagatcctgc     1740

tagggaaggc caccctgtat gctgtgctgg tcagcgccct tgtgttgatg gccatggtca     1800

agagaaagga tttcggatcc atggctgcag gaggtcccgg cgcggggtct gcggccccgg     1860

tctcctccac atcctccctt cccctggctg ctctcaacat gcgagtgcgg cgccgcctgt     1920

ctctgttctt gaacgtgcgg acacaggtgg cggccgactg gaccgcgctg gcggaggaga     1980

tggactttga gtacttggag atccggcaac tggagacaca agcggacccc actggcaggc     2040

tgctggacgc ctggcaggga cgccctggcg cctctgtagg ccgactgctc gagctgctta     2100

ccaagctggg ccgcgacgac gtgctgctgg agctgggacc cagcattgag gaggattgcc     2160

aaaagtatat cttgaagcag cagcaggagg aggctgagaa gcctttacag gtggccgctg     2220

tagacagcag tgtcccacgg acagcagagc tggcgggcat caccacactt gatgaccccc     2280

tgggg                                                                 2285


<210>  12
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


<210>  13
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human CD8a without the intracellular signaling domain

<400>  13

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
        195                 200             


<210>  14
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human CD8a-MyD88 where MyD88 lacks the TIR domain

<400>  14

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser Thr Ser Ser Leu Pro 
    210                 215                 220                 


Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg Leu Ser Leu Phe Leu 
225                 230                 235                 240 


Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr Ala Leu Ala Glu Glu 
                245                 250                 255     


Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu Glu Thr Gln Ala Asp 
            260                 265                 270         


Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly Arg Pro Gly Ala Ser 
        275                 280                 285             


Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu Gly Arg Asp Asp Val 
    290                 295                 300                 


Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp Cys Gln Lys Tyr Ile 
305                 310                 315                 320 


Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro Leu Gln Val Ala Ala 
                325                 330                 335     


Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu Ala Gly Ile Thr Thr 
            340                 345                 350         


Leu Asp Asp Pro Leu Gly 
        355             


<210>  15
<211>  247
<212>  PRT
<213>  Mus musculus

<400>  15

Met Ala Ser Pro Leu Thr Arg Phe Leu Ser Leu Asn Leu Leu Leu Leu 
1               5                   10                  15      


Gly Glu Ser Ile Ile Leu Gly Ser Gly Glu Ala Lys Pro Gln Ala Pro 
            20                  25                  30          


Glu Leu Arg Ile Phe Pro Lys Lys Met Asp Ala Glu Leu Gly Gln Lys 
        35                  40                  45              


Val Asp Leu Val Cys Glu Val Leu Gly Ser Val Ser Gln Gly Cys Ser 
    50                  55                  60                  


Trp Leu Phe Gln Asn Ser Ser Ser Lys Leu Pro Gln Pro Thr Phe Val 
65                  70                  75                  80  


Val Tyr Met Ala Ser Ser His Asn Lys Ile Thr Trp Asp Glu Lys Leu 
                85                  90                  95      


Asn Ser Ser Lys Leu Phe Ser Ala Met Arg Asp Thr Asn Asn Lys Tyr 
            100                 105                 110         


Val Leu Thr Leu Asn Lys Phe Ser Lys Glu Asn Glu Gly Tyr Tyr Phe 
        115                 120                 125             


Cys Ser Val Ile Ser Asn Ser Val Met Tyr Phe Ser Ser Val Val Pro 
    130                 135                 140                 


Val Leu Gln Lys Val Asn Ser Thr Thr Thr Lys Pro Val Leu Arg Thr 
145                 150                 155                 160 


Pro Ser Pro Val His Pro Thr Gly Thr Ser Gln Pro Gln Arg Pro Glu 
                165                 170                 175     


Asp Cys Arg Pro Arg Gly Ser Val Lys Gly Thr Gly Leu Asp Phe Ala 
            180                 185                 190         


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu 
        195                 200                 205             


Leu Leu Ser Leu Ile Ile Thr Leu Ile Cys Tyr His Arg Ser Arg Lys 
    210                 215                 220                 


Arg Val Cys Lys Cys Pro Arg Pro Leu Val Arg Gln Glu Gly Lys Pro 
225                 230                 235                 240 


Arg Pro Ser Glu Lys Ile Val 
                245         


<210>  16
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse CD8a without the intracellular signaling domain

<400>  16

Met Ala Ser Pro Leu Thr Arg Phe Leu Ser Leu Asn Leu Leu Leu Leu 
1               5                   10                  15      


Gly Glu Ser Ile Ile Leu Gly Ser Gly Glu Ala Lys Pro Gln Ala Pro 
            20                  25                  30          


Glu Leu Arg Ile Phe Pro Lys Lys Met Asp Ala Glu Leu Gly Gln Lys 
        35                  40                  45              


Val Asp Leu Val Cys Glu Val Leu Gly Ser Val Ser Gln Gly Cys Ser 
    50                  55                  60                  


Trp Leu Phe Gln Asn Ser Ser Ser Lys Leu Pro Gln Pro Thr Phe Val 
65                  70                  75                  80  


Val Tyr Met Ala Ser Ser His Asn Lys Ile Thr Trp Asp Glu Lys Leu 
                85                  90                  95      


Asn Ser Ser Lys Leu Phe Ser Ala Met Arg Asp Thr Asn Asn Lys Tyr 
            100                 105                 110         


Val Leu Thr Leu Asn Lys Phe Ser Lys Glu Asn Glu Gly Tyr Tyr Phe 
        115                 120                 125             


Cys Ser Val Ile Ser Asn Ser Val Met Tyr Phe Ser Ser Val Val Pro 
    130                 135                 140                 


Val Leu Gln Lys Val Asn Ser Thr Thr Thr Lys Pro Val Leu Arg Thr 
145                 150                 155                 160 


Pro Ser Pro Val His Pro Thr Gly Thr Ser Gln Pro Gln Arg Pro Glu 
                165                 170                 175     


Asp Cys Arg Pro Arg Gly Ser Val Lys Gly Thr Gly Leu Asp Phe Ala 
            180                 185                 190         


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu 
        195                 200                 205             


Leu Leu Ser Leu Ile Ile Thr Leu Ile 
    210                 215         


<210>  17
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse CD8a-human MyD88 where MyD88 lacks TIR domain

<400>  17

Met Ala Ser Pro Leu Thr Arg Phe Leu Ser Leu Asn Leu Leu Leu Leu 
1               5                   10                  15      


Gly Glu Ser Ile Ile Leu Gly Ser Gly Glu Ala Lys Pro Gln Ala Pro 
            20                  25                  30          


Glu Leu Arg Ile Phe Pro Lys Lys Met Asp Ala Glu Leu Gly Gln Lys 
        35                  40                  45              


Val Asp Leu Val Cys Glu Val Leu Gly Ser Val Ser Gln Gly Cys Ser 
    50                  55                  60                  


Trp Leu Phe Gln Asn Ser Ser Ser Lys Leu Pro Gln Pro Thr Phe Val 
65                  70                  75                  80  


Val Tyr Met Ala Ser Ser His Asn Lys Ile Thr Trp Asp Glu Lys Leu 
                85                  90                  95      


Asn Ser Ser Lys Leu Phe Ser Ala Met Arg Asp Thr Asn Asn Lys Tyr 
            100                 105                 110         


Val Leu Thr Leu Asn Lys Phe Ser Lys Glu Asn Glu Gly Tyr Tyr Phe 
        115                 120                 125             


Cys Ser Val Ile Ser Asn Ser Val Met Tyr Phe Ser Ser Val Val Pro 
    130                 135                 140                 


Val Leu Gln Lys Val Asn Ser Thr Thr Thr Lys Pro Val Leu Arg Thr 
145                 150                 155                 160 


Pro Ser Pro Val His Pro Thr Gly Thr Ser Gln Pro Gln Arg Pro Glu 
                165                 170                 175     


Asp Cys Arg Pro Arg Gly Ser Val Lys Gly Thr Gly Leu Asp Phe Ala 
            180                 185                 190         


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu 
        195                 200                 205             


Leu Leu Ser Leu Ile Ile Thr Leu Ile Met Ala Ala Gly Gly Pro Gly 
    210                 215                 220                 


Ala Gly Ser Ala Ala Pro Val Ser Ser Thr Ser Ser Leu Pro Leu Ala 
225                 230                 235                 240 


Ala Leu Asn Met Arg Val Arg Arg Arg Leu Ser Leu Phe Leu Asn Val 
                245                 250                 255     


Arg Thr Gln Val Ala Ala Asp Trp Thr Ala Leu Ala Glu Glu Met Asp 
            260                 265                 270         


Phe Glu Tyr Leu Glu Ile Arg Gln Leu Glu Thr Gln Ala Asp Pro Thr 
        275                 280                 285             


Gly Arg Leu Leu Asp Ala Trp Gln Gly Arg Pro Gly Ala Ser Val Gly 
    290                 295                 300                 


Arg Leu Leu Glu Leu Leu Thr Lys Leu Gly Arg Asp Asp Val Leu Leu 
305                 310                 315                 320 


Glu Leu Gly Pro Ser Ile Glu Glu Asp Cys Gln Lys Tyr Ile Leu Lys 
                325                 330                 335     


Gln Gln Gln Glu Glu Ala Glu Lys Pro Leu Gln Val Ala Ala Val Asp 
            340                 345                 350         


Ser Ser Val Pro Arg Thr Ala Glu Leu Ala Gly Ile Thr Thr Leu Asp 
        355                 360                 365             


Asp Pro Leu Gly 
    370         


<210>  18
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human CD8a TM-MyD88

<400>  18

Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    50                  55                  60                  


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
65                  70                  75                  80  


His Arg Asn Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro 
                85                  90                  95      


Val Ser Ser Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val 
            100                 105                 110         


Arg Arg Arg Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala 
        115                 120                 125             


Asp Trp Thr Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile 
    130                 135                 140                 


Arg Gln Leu Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala 
145                 150                 155                 160 


Trp Gln Gly Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu 
                165                 170                 175     


Thr Lys Leu Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile 
            180                 185                 190         


Glu Glu Asp Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala 
        195                 200                 205             


Glu Lys Pro Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro Arg Thr 
    210                 215                 220                 


Ala Glu Leu Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly 
225                 230                 235             


<210>  19
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse CD8a-human CD28-human 41BB-human CD3zeta

<400>  19

Met Ala Ser Pro Leu Thr Arg Phe Leu Ser Leu Asn Leu Leu Leu Leu 
1               5                   10                  15      


Gly Glu Ser Ile Ile Leu Gly Ser Gly Glu Ala Lys Pro Gln Ala Pro 
            20                  25                  30          


Glu Leu Arg Ile Phe Pro Lys Lys Met Asp Ala Glu Leu Gly Gln Lys 
        35                  40                  45              


Val Asp Leu Val Cys Glu Val Leu Gly Ser Val Ser Gln Gly Cys Ser 
    50                  55                  60                  


Trp Leu Phe Gln Asn Ser Ser Ser Lys Leu Pro Gln Pro Thr Phe Val 
65                  70                  75                  80  


Val Tyr Met Ala Ser Ser His Asn Lys Ile Thr Trp Asp Glu Lys Leu 
                85                  90                  95      


Asn Ser Ser Lys Leu Phe Ser Ala Met Arg Asp Thr Asn Asn Lys Tyr 
            100                 105                 110         


Val Leu Thr Leu Asn Lys Phe Ser Lys Glu Asn Glu Gly Tyr Tyr Phe 
        115                 120                 125             


Cys Ser Val Ile Ser Asn Ser Val Met Tyr Phe Ser Ser Val Val Pro 
    130                 135                 140                 


Val Leu Gln Lys Val Asn Ser Thr Thr Thr Lys Pro Val Leu Arg Thr 
145                 150                 155                 160 


Pro Ser Pro Val His Pro Thr Gly Thr Ser Gln Pro Gln Arg Pro Glu 
                165                 170                 175     


Asp Cys Arg Pro Arg Gly Ser Val Lys Gly Thr Gly Leu Asp Phe Ala 
            180                 185                 190         


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu 
        195                 200                 205             


Leu Leu Ser Leu Ile Ile Thr Leu Ile Arg Ser Lys Arg Ser Arg Leu 
    210                 215                 220                 


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
225                 230                 235                 240 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
                245                 250                 255     


Arg Ser Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
            260                 265                 270         


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
        275                 280                 285             


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
    290                 295                 300                 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
305                 310                 315                 320 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
                325                 330                 335     


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
            340                 345                 350         


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
        355                 360                 365             


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
    370                 375                 380                 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
385                 390                 395                 400 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
                405                 410                 415     


Arg 
    


<210>  20
<211>  575
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human CD4-MyD88 where MyD88 lacks the TIR domain

<400>  20

Met Glu Thr Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu 
1               5                   10                  15      


Gln Leu Ala Leu Leu Pro Ala Ala Thr Gln Gly Lys Lys Val Val Leu 
            20                  25                  30          


Gly Lys Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys 
        35                  40                  45              


Lys Ser Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu 
    50                  55                  60                  


Gly Asn Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp 
65                  70                  75                  80  


Arg Ala Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu 
                85                  90                  95      


Ile Ile Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu 
            100                 105                 110         


Val Glu Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr 
        115                 120                 125             


Ala Asn Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr 
    130                 135                 140                 


Leu Glu Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro 
145                 150                 155                 160 


Arg Gly Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu 
                165                 170                 175     


Glu Leu Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln 
            180                 185                 190         


Lys Lys Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Phe Gln Lys 
        195                 200                 205             


Ala Ser Ser Ile Val Tyr Lys Lys Glu Gly Glu Gln Val Glu Phe Ser 
    210                 215                 220                 


Phe Pro Leu Ala Phe Thr Val Glu Lys Leu Thr Gly Ser Gly Glu Leu 
225                 230                 235                 240 


Trp Trp Gln Ala Glu Arg Ala Ser Ser Ser Lys Ser Trp Ile Thr Phe 
                245                 250                 255     


Asp Leu Lys Asn Lys Glu Val Ser Val Lys Arg Val Thr Gln Asp Pro 
            260                 265                 270         


Lys Leu Gln Met Gly Lys Lys Leu Pro Leu His Leu Thr Leu Pro Gln 
        275                 280                 285             


Ala Leu Pro Gln Tyr Ala Gly Ser Gly Asn Leu Thr Leu Ala Leu Glu 
    290                 295                 300                 


Ala Lys Thr Gly Lys Leu His Gln Glu Val Asn Leu Val Val Met Arg 
305                 310                 315                 320 


Ala Thr Gln Leu Gln Lys Asn Leu Thr Cys Glu Val Trp Gly Pro Thr 
                325                 330                 335     


Ser Pro Lys Leu Met Leu Ser Leu Lys Leu Glu Asn Lys Glu Ala Lys 
            340                 345                 350         


Val Ser Lys Arg Glu Lys Ala Val Trp Val Leu Asn Pro Glu Ala Gly 
        355                 360                 365             


Met Trp Gln Cys Leu Leu Ser Asp Ser Gly Gln Val Leu Leu Glu Ser 
    370                 375                 380                 


Asn Ile Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala 
385                 390                 395                 400 


Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu 
                405                 410                 415     


Gly Ile Phe Phe Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala 
            420                 425                 430         


Pro Val Ser Ser Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg 
        435                 440                 445             


Val Arg Arg Arg Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala 
    450                 455                 460                 


Ala Asp Trp Thr Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu 
465                 470                 475                 480 


Ile Arg Gln Leu Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp 
                485                 490                 495     


Ala Trp Gln Gly Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu 
            500                 505                 510         


Leu Thr Lys Leu Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser 
        515                 520                 525             


Ile Glu Glu Asp Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu Glu 
    530                 535                 540                 


Ala Glu Lys Pro Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro Arg 
545                 550                 555                 560 


Thr Ala Glu Leu Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly 
                565                 570                 575 


<210>  21
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse CD4-human MyD88 where MyD88 lacks the TIR domain

<400>  21

Met Glu Thr Cys Arg Ala Ile Ser Leu Arg Arg Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Gln Leu Ser Gln Leu Leu Ala Val Thr Gln Gly Lys Thr Leu Val 
            20                  25                  30          


Leu Gly Lys Glu Gly Glu Ser Ala Glu Leu Pro Cys Glu Ser Ser Gln 
        35                  40                  45              


Lys Lys Ile Thr Val Phe Thr Trp Lys Phe Ser Asp Gln Arg Lys Ile 
    50                  55                  60                  


Leu Gly Gln His Gly Lys Gly Val Leu Ile Arg Gly Gly Ser Pro Ser 
65                  70                  75                  80  


Gln Phe Asp Arg Phe Asp Ser Lys Lys Gly Ala Trp Glu Lys Gly Ser 
                85                  90                  95      


Phe Pro Leu Ile Ile Asn Lys Leu Lys Met Glu Thr Glu Asp Ser Gln 
            100                 105                 110         


Thr Tyr Ile Cys Glu Leu Glu Asn Arg Lys Glu Glu Val Glu Leu Trp 
        115                 120                 125             


Val Phe Lys Val Thr Phe Ser Pro Gly Thr Ser Leu Leu Gln Gly Gln 
    130                 135                 140                 


Ser Leu Thr Leu Thr Leu Asp Ser Asn Ser Lys Val Ser Asn Pro Leu 
145                 150                 155                 160 


Thr Glu Cys Lys His Lys Lys Gly Lys Val Val Ser Gly Ser Lys Val 
                165                 170                 175     


Leu Ser Met Ser Asn Leu Arg Val Gln Asp Ser Asp Phe Trp Asn Cys 
            180                 185                 190         


Thr Val Thr Leu Asp Gln Lys Lys Asn Trp Phe Gly Met Thr Leu Ser 
        195                 200                 205             


Val Leu Gly Phe Gln Ser Thr Ala Ile Thr Ala Tyr Lys Ser Glu Gly 
    210                 215                 220                 


Glu Ser Ala Glu Phe Ser Phe Pro Leu Asn Phe Ala Glu Glu Asn Gly 
225                 230                 235                 240 


Trp Gly Glu Leu Met Trp Lys Ala Glu Lys Asp Ser Phe Phe Gln Pro 
                245                 250                 255     


Trp Ile Ser Phe Ser Ile Lys Asn Lys Glu Val Ser Val Gln Lys Ser 
            260                 265                 270         


Thr Lys Asp Leu Lys Leu Gln Leu Lys Glu Thr Leu Pro Leu Thr Leu 
        275                 280                 285             


Lys Ile Pro Gln Val Ser Leu Gln Phe Ala Gly Ser Gly Asn Leu Thr 
    290                 295                 300                 


Leu Thr Leu Asp Lys Gly Thr Leu His Gln Glu Val Asn Leu Val Val 
305                 310                 315                 320 


Met Lys Val Ala Gln Leu Asn Asn Thr Leu Thr Cys Glu Val Met Gly 
                325                 330                 335     


Pro Thr Ser Pro Lys Met Arg Leu Thr Leu Lys Gln Glu Asn Gln Glu 
            340                 345                 350         


Ala Arg Val Ser Glu Glu Gln Lys Val Val Gln Val Val Ala Pro Glu 
        355                 360                 365             


Thr Gly Leu Trp Gln Cys Leu Leu Ser Glu Gly Asp Lys Val Lys Met 
    370                 375                 380                 


Asp Ser Arg Ile Gln Val Leu Ser Arg Gly Val Asn Gln Thr Val Phe 
385                 390                 395                 400 


Leu Ala Cys Val Leu Gly Gly Ser Phe Gly Phe Leu Gly Phe Leu Gly 
                405                 410                 415     


Leu Cys Ile Leu Cys Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala 
            420                 425                 430         


Ala Pro Val Ser Ser Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met 
        435                 440                 445             


Arg Val Arg Arg Arg Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val 
    450                 455                 460                 


Ala Ala Asp Trp Thr Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu 
465                 470                 475                 480 


Glu Ile Arg Gln Leu Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu 
                485                 490                 495     


Asp Ala Trp Gln Gly Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu 
            500                 505                 510         


Leu Leu Thr Lys Leu Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro 
        515                 520                 525             


Ser Ile Glu Glu Asp Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu 
    530                 535                 540                 


Glu Ala Glu Lys Pro Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro 
545                 550                 555                 560 


Arg Thr Ala Glu Leu Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly 
                565                 570                 575     


<210>  22
<211>  780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human DMF5 TCR-MyD88 where MyD88 lacks the TIR domain

<400>  22

Met Glu Thr Met Glu Thr Lys Ser Leu Arg Val Leu Leu Val Ile Leu 
1               5                   10                  15      


Trp Leu Gln Leu Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln 
            20                  25                  30          


Asn Ser Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn 
        35                  40                  45              


Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln 
    50                  55                  60                  


Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met Glu Thr Phe Ile Tyr Ser 
65                  70                  75                  80  


Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala 
                85                  90                  95      


Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser 
            100                 105                 110         


Ala Thr Tyr Leu Cys Ala Val Asn Phe Gly Gly Gly Lys Leu Ile Phe 
        115                 120                 125             


Gly Gln Gly Thr Glu Leu Ser Val Lys Pro Asn Ile Gln Asn Pro Asp 
    130                 135                 140                 


Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val 
145                 150                 155                 160 


Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys 
                165                 170                 175     


Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Glu Thr 
            180                 185                 190         


Arg Ser Met Glu Thr Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser 
        195                 200                 205             


Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile 
    210                 215                 220                 


Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys 
225                 230                 235                 240 


Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn 
                245                 250                 255     


Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
            260                 265                 270         


Asn Leu Leu Met Glu Thr Thr Leu Arg Leu Trp Ser Ser Arg Ala Lys 
        275                 280                 285             


Arg Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn 
    290                 295                 300                 


Pro Gly Pro Met Glu Thr Arg Ile Arg Leu Leu Cys Cys Val Ala Phe 
305                 310                 315                 320 


Ser Leu Leu Trp Ala Gly Pro Val Ile Ala Gly Ile Thr Gln Ala Pro 
                325                 330                 335     


Thr Ser Gln Ile Leu Ala Ala Gly Arg Arg Met Glu Thr Thr Leu Arg 
            340                 345                 350         


Cys Thr Gln Asp Met Glu Thr Arg His Asn Ala Met Tyr Trp Tyr Arg 
        355                 360                 365             


Gln Asp Leu Gly Leu Gly Leu Arg Leu Ile His Tyr Ser Asn Thr Ala 
    370                 375                 380                 


Gly Thr Thr Gly Lys Gly Glu Val Pro Asp Gly Tyr Ser Val Ser Arg 
385                 390                 395                 400 


Ala Asn Thr Asp Asp Phe Pro Leu Thr Leu Ala Ser Ala Val Pro Ser 
                405                 410                 415     


Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Leu Ser Phe Gly Thr Glu 
            420                 425                 430         


Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val Glu Asp Leu Asn 
        435                 440                 445             


Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu 
    450                 455                 460                 


Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe 
465                 470                 475                 480 


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
                485                 490                 495     


His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala 
            500                 505                 510         


Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
        515                 520                 525             


Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
    530                 535                 540                 


Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro 
545                 550                 555                 560 


Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
                565                 570                 575     


Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
            580                 585                 590         


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
        595                 600                 605             


Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe Gly Ser Met 
    610                 615                 620                 


Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser Thr 
625                 630                 635                 640 


Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg Leu 
                645                 650                 655     


Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr Ala 
            660                 665                 670         


Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu Glu 
        675                 680                 685             


Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly Arg 
    690                 695                 700                 


Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu Gly 
705                 710                 715                 720 


Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp Cys 
                725                 730                 735     


Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro Leu 
            740                 745                 750         


Gln Val Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu Ala 
        755                 760                 765             


Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly Gly Ser 
    770                 775                 780 


<210>  23
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse CD8a protein with K73A mutation

<400>  23

Met Ala Ser Pro Leu Thr Arg Phe Leu Ser Leu Asn Leu Leu Leu Leu 
1               5                   10                  15      


Gly Glu Ser Ile Ile Leu Gly Ser Gly Glu Ala Lys Pro Gln Ala Pro 
            20                  25                  30          


Glu Leu Arg Ile Phe Pro Lys Lys Met Asp Ala Glu Leu Gly Gln Lys 
        35                  40                  45              


Val Asp Leu Val Cys Glu Val Leu Gly Ser Val Ser Gln Gly Cys Ser 
    50                  55                  60                  


Trp Leu Phe Gln Asn Ser Ser Ser Ala Leu Pro Gln Pro Thr Phe Val 
65                  70                  75                  80  


Val Tyr Met Ala Ser Ser His Asn Lys Ile Thr Trp Asp Glu Lys Leu 
                85                  90                  95      


Asn Ser Ser Lys Leu Phe Ser Ala Met Arg Asp Thr Asn Asn Lys Tyr 
            100                 105                 110         


Val Leu Thr Leu Asn Lys Phe Ser Lys Glu Asn Glu Gly Tyr Tyr Phe 
        115                 120                 125             


Cys Ser Val Ile Ser Asn Ser Val Met Tyr Phe Ser Ser Val Val Pro 
    130                 135                 140                 


Val Leu Gln Lys Val Asn Ser Thr Thr Thr Lys Pro Val Leu Arg Thr 
145                 150                 155                 160 


Pro Ser Pro Val His Pro Thr Gly Thr Ser Gln Pro Gln Arg Pro Glu 
                165                 170                 175     


Asp Cys Arg Pro Arg Gly Ser Val Lys Gly Thr Gly Leu Asp Phe Ala 
            180                 185                 190         


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu 
        195                 200                 205             


Leu Leu Ser Leu Ile Ile Thr Leu Ile Cys Tyr His Arg Ser Arg Lys 
    210                 215                 220                 


Arg Val Cys Lys Cys Pro Arg Pro Leu Val Arg Gln Glu Gly Lys Pro 
225                 230                 235                 240 


Arg Pro Ser Glu Lys Ile Val 
                245         


<210>  24
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser 
1               5                   10                  15      


Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg 
            20                  25                  30          


Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr 
        35                  40                  45              


Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu 
    50                  55                  60                  


Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly 
65                  70                  75                  80  


Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu 
                85                  90                  95      


Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp 
            100                 105                 110         


Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro 
        115                 120                 125             


Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu 
    130                 135                 140                 


Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly His Met Pro Glu Arg 
145                 150                 155                 160 


Phe Asp Ala Phe Ile Cys Tyr Cys Pro Ser Asp Ile Gln Phe Val Gln 
                165                 170                 175     


Glu Met Ile Arg Gln Leu Glu Gln Thr Asn Tyr Arg Leu Lys Leu Cys 
            180                 185                 190         


Val Ser Asp Arg Asp Val Leu Pro Gly Thr Cys Val Trp Ser Ile Ala 
        195                 200                 205             


Ser Glu Leu Ile Glu Lys Arg Cys Arg Arg Met Val Val Val Val Ser 
    210                 215                 220                 


Asp Asp Tyr Leu Gln Ser Lys Glu Cys Asp Phe Gln Thr Lys Phe Ala 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Ala His Gln Lys Arg Leu Ile Pro Ile Lys 
                245                 250                 255     


Tyr Lys Ala Met Lys Lys Glu Phe Pro Ser Ile Leu Arg Phe Ile Thr 
            260                 265                 270         


Val Cys Asp Tyr Thr Asn Pro Cys Thr Lys Ser Trp Phe Trp Thr Arg 
        275                 280                 285             


Leu Ala Lys Ala Leu Ser Leu Pro 
    290                 295     


