                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
 
<120>  Anti-Galectin Antibody Biomarkers Predictive Of Anti-Immune 
       Checkpoint And Anti-Angiogenesis Responses

<130>  DFS-146.25

<140>  PCT/US2015/058276
<141>  2015-10-30

<150>  62/074,779
<151>  2014-11-04

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  408
<212>  DNA
<213>  Homo sapiens

<400>  1
atggcttgtg gtctggtcgc cagcaacctg aatctcaaac ctggagagtg ccttcgagtg       60

cgaggcgagg tggctcctga cgctaagagc ttcgtgctga acctgggcaa agacagcaac      120

aacctgtgcc tgcacttcaa ccctcgcttc aacgcccacg gcgacgccaa caccatcgtg      180

tgcaacagca aggacggcgg ggcctggggg accgagcagc gggaggctgt ctttcccttc      240

cagcctggaa gtgttgcaga ggtgtgcatc accttcgacc aggccaacct gaccgtcaag      300

ctgccagatg gatacgaatt caagttcccc aaccgcctca acctggaggc catcaactac      360

atggcagctg acggtgactt caagatcaaa tgtgtggcct ttgactga                   408


<210>  2
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Cys Gly Leu Val Ala Ser Asn Leu Asn Leu Lys Pro Gly Glu 
1               5                   10                  15      


Cys Leu Arg Val Arg Gly Glu Val Ala Pro Asp Ala Lys Ser Phe Val 
            20                  25                  30          


Leu Asn Leu Gly Lys Asp Ser Asn Asn Leu Cys Leu His Phe Asn Pro 
        35                  40                  45              


Arg Phe Asn Ala His Gly Asp Ala Asn Thr Ile Val Cys Asn Ser Lys 
    50                  55                  60                  


Asp Gly Gly Ala Trp Gly Thr Glu Gln Arg Glu Ala Val Phe Pro Phe 
65                  70                  75                  80  


Gln Pro Gly Ser Val Ala Glu Val Cys Ile Thr Phe Asp Gln Ala Asn 
                85                  90                  95      


Leu Thr Val Lys Leu Pro Asp Gly Tyr Glu Phe Lys Phe Pro Asn Arg 
            100                 105                 110         


Leu Asn Leu Glu Ala Ile Asn Tyr Met Ala Ala Asp Gly Asp Phe Lys 
        115                 120                 125             


Ile Lys Cys Val Ala Phe Asp 
    130                 135 


<210>  3
<211>  408
<212>  DNA
<213>  Mus musculus

<400>  3
atggcctgtg gtctggtcgc cagcaacctg aatctcaaac ctggggaatg tctcaaagtt       60

cggggagagg tggcctcgga cgccaagagc tttgtgctga acctgggaaa agacagcaac      120

aacctgtgcc tacacttcaa tcctcgcttc aatgcccatg gagacgccaa caccattgtg      180

tgtaacacca aggaagatgg gacctgggga accgaacacc gggaacctgc cttccccttc      240

cagcccggga gcatcacaga ggtgtgcatc acctttgacc aggctgacct gaccatcaag      300

ctgccagacg gacatgaatt caagttcccc aaccgcctca acatggaggc catcaactac      360

atggcggcgg atggagactt caagattaag tgcgtggcct ttgagtga                   408


<210>  4
<211>  135
<212>  PRT
<213>  Mus musculus

<400>  4

Met Ala Cys Gly Leu Val Ala Ser Asn Leu Asn Leu Lys Pro Gly Glu 
1               5                   10                  15      


Cys Leu Lys Val Arg Gly Glu Val Ala Ser Asp Ala Lys Ser Phe Val 
            20                  25                  30          


Leu Asn Leu Gly Lys Asp Ser Asn Asn Leu Cys Leu His Phe Asn Pro 
        35                  40                  45              


Arg Phe Asn Ala His Gly Asp Ala Asn Thr Ile Val Cys Asn Thr Lys 
    50                  55                  60                  


Glu Asp Gly Thr Trp Gly Thr Glu His Arg Glu Pro Ala Phe Pro Phe 
65                  70                  75                  80  


Gln Pro Gly Ser Ile Thr Glu Val Cys Ile Thr Phe Asp Gln Ala Asp 
                85                  90                  95      


Leu Thr Ile Lys Leu Pro Asp Gly His Glu Phe Lys Phe Pro Asn Arg 
            100                 105                 110         


Leu Asn Met Glu Ala Ile Asn Tyr Met Ala Ala Asp Gly Asp Phe Lys 
        115                 120                 125             


Ile Lys Cys Val Ala Phe Glu 
    130                 135 


<210>  5
<211>  753
<212>  DNA
<213>  Homo sapiens

<400>  5
atggcagaca atttttcgct ccatgatgcg ttatctgggt ctggaaaccc aaaccctcaa       60

ggatggcctg gcgcatgggg gaaccagcct gctggggcag ggggctaccc aggggcttcc      120

tatcctgggg cctaccccgg gcaggcaccc ccaggggctt atcctggaca ggcacctcca      180

ggcgcctacc ctggagcacc tggagcttat cccggagcac ctgcacctgg agtctaccca      240

gggccaccca gcggccctgg ggcctaccca tcttctggac agccaagtgc caccggagcc      300

taccctgcca ctggccccta tggcgcccct gctgggccac tgattgtgcc ttataacctg      360

cctttgcctg ggggagtggt gcctcgcatg ctgataacaa ttctgggcac ggtgaagccc      420

aatgcaaaca gaattgcttt agatttccaa agagggaatg atgttgcctt ccactttaac      480

ccacgcttca atgagaacaa caggagagtc attgtttgca atacaaagct ggataataac      540

tggggaaggg aagaaagaca gtcggttttc ccatttgaaa gtgggaaacc attcaaaata      600

caagtactgg ttgaacctga ccacttcaag gttgcagtga atgatgctca cttgttgcag      660

tacaatcatc gggttaaaaa actcaatgaa atcagcaaac tgggaatttc tggtgacata      720

gacctcacca gtgcttcata taccatgata taa                                   753


<210>  6
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn 
1               5                   10                  15      


Pro Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly 
            20                  25                  30          


Ala Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln 
        35                  40                  45              


Ala Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro 
    50                  55                  60                  


Gly Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro 
65                  70                  75                  80  


Gly Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser 
                85                  90                  95      


Ala Thr Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly 
            100                 105                 110         


Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro 
        115                 120                 125             


Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg 
    130                 135                 140                 


Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn 
145                 150                 155                 160 


Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys 
                165                 170                 175     


Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe 
            180                 185                 190         


Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His 
        195                 200                 205             


Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg 
    210                 215                 220                 


Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile 
225                 230                 235                 240 


Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile 
                245                 250 


<210>  7
<211>  603
<212>  DNA
<213>  Homo sapiens

<400>  7
atggcagaca atttttcgct ccatgatgcg ttatctgggt ctggaaaccc aaaccctcaa       60

ggatggcctg gcgcatgggg gaaccagcct gctggggcag ggggctaccc aggggcttcc      120

tatcctgggg cctaccccgg gcaggcaccc ccaggggctt atcctggaca ggcacctcca      180

ggcgcctacc ctggagcacc tggagcttat cccggagcac ctgcacctgg agtctaccca      240

gggccaccca gcggccctgg ggcctaccca tcttctggac agccaagtgc caccggagcc      300

taccctgcca ctggccccta tggcgcccct gctgggccac tgattgtgcc ttataacctg      360

cctttgcctg ggggagtggt gcctcgcatg ctgataacaa ttctgggcac ggtgaagccc      420

aatgcaaaca gaattgcttt agatttccaa agagggaatg atgttgcctt ccactttaac      480

ccacgcttca atgagaacaa caggagagtc attgtttgca cttacatgtg taaaggtttc      540

atgttcactg tgagtgaaaa tttttacatt catcaatatc cctcttgtaa gtcatctact      600

taa                                                                    603


<210>  8
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn 
1               5                   10                  15      


Pro Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly 
            20                  25                  30          


Ala Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln 
        35                  40                  45              


Ala Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro 
    50                  55                  60                  


Gly Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro 
65                  70                  75                  80  


Gly Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser 
                85                  90                  95      


Ala Thr Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly 
            100                 105                 110         


Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro 
        115                 120                 125             


Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg 
    130                 135                 140                 


Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn 
145                 150                 155                 160 


Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Thr Tyr Met 
                165                 170                 175     


Cys Lys Gly Phe Met Phe Thr Val Ser Glu Asn Phe Tyr Ile His Gln 
            180                 185                 190         


Tyr Pro Ser Cys Lys Ser Ser Thr 
        195                 200 


<210>  9
<211>  795
<212>  DNA
<213>  Mus musculus

<400>  9
atggcagaca gcttttcgct taacgatgcc ttagctggct ctggaaaccc aaaccctcaa       60

ggatatccgg gtgcatgggg gaaccagcct ggggcagggg gctacccagg ggctgcttat      120

cctggggcct acccaggaca agctcctcca ggggcctacc caggacaggc tcctccaggg      180

gcctacccag gacaggctcc tcctagtgcc taccccggcc caactgcccc tggagcttat      240

cctggcccaa ctgcccctgg agcttatcct ggctcaactg cccctggagc cttcccaggg      300

caacctgggg cacctggggc ctaccccagt gctcctggag gctatcctgc tgctggccct      360

tatggtgtcc ccgctggacc actgacggtg ccctatgacc tgcccttgcc tggaggagtc      420

atgccccgca tgctgatcac aatcatgggc acagtgaaac ccaacgcaaa caggattgtt      480

ctagatttca ggagagggaa tgatgttgcc ttccacttta acccccgctt caatgagaac      540

aacaggagag tcattgtgtg taacacgaag caggacaata actggggaaa ggaagaaaga      600

cagtcagcct tcccctttga gagtggcaaa ccattcaaaa tacaagtcct ggttgaagct      660

gaccacttca aggttgcggt caacgatgct cacctactgc agtacaacca tcggatgaag      720

aacctccggg aaatcagcca actggggatc agtggtgaca taaccctcac cagcgctaac      780

cacgccatga tctaa                                                       795


<210>  10
<211>  264
<212>  PRT
<213>  Mus musculus

<400>  10

Met Ala Asp Ser Phe Ser Leu Asn Asp Ala Leu Ala Gly Ser Gly Asn 
1               5                   10                  15      


Pro Asn Pro Gln Gly Tyr Pro Gly Ala Trp Gly Asn Gln Pro Gly Ala 
            20                  25                  30          


Gly Gly Tyr Pro Gly Ala Ala Tyr Pro Gly Ala Tyr Pro Gly Gln Ala 
        35                  40                  45              


Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro Gly 
    50                  55                  60                  


Gln Ala Pro Pro Ser Ala Tyr Pro Gly Pro Thr Ala Pro Gly Ala Tyr 
65                  70                  75                  80  


Pro Gly Pro Thr Ala Pro Gly Ala Tyr Pro Gly Ser Thr Ala Pro Gly 
                85                  90                  95      


Ala Phe Pro Gly Gln Pro Gly Ala Pro Gly Ala Tyr Pro Ser Ala Pro 
            100                 105                 110         


Gly Gly Tyr Pro Ala Ala Gly Pro Tyr Gly Val Pro Ala Gly Pro Leu 
        115                 120                 125             


Thr Val Pro Tyr Asp Leu Pro Leu Pro Gly Gly Val Met Pro Arg Met 
    130                 135                 140                 


Leu Ile Thr Ile Met Gly Thr Val Lys Pro Asn Ala Asn Arg Ile Val 
145                 150                 155                 160 


Leu Asp Phe Arg Arg Gly Asn Asp Val Ala Phe His Phe Asn Pro Arg 
                165                 170                 175     


Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys Gln Asp 
            180                 185                 190         


Asn Asn Trp Gly Lys Glu Glu Arg Gln Ser Ala Phe Pro Phe Glu Ser 
        195                 200                 205             


Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Ala Asp His Phe Lys 
    210                 215                 220                 


Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg Met Lys 
225                 230                 235                 240 


Asn Leu Arg Glu Ile Ser Gln Leu Gly Ile Ser Gly Asp Ile Thr Leu 
                245                 250                 255     


Thr Ser Ala Asn His Ala Met Ile 
            260                 


<210>  11
<211>  795
<212>  DNA
<213>  Mus musculus

<400>  11
atggcagaca gcttttcgct taacgatgcc ttagctggct ctggaaaccc aaaccctcaa       60

ggatatccgg gtgcatgggg gaaccagcct ggggcagggg gctacccagg ggctgcttat      120

cctggggcct acccaggaca agctcctcca ggggcctacc caggacaggc tcctccaggg      180

gcctacccag gacaggctcc tcctagtgcc taccccggcc caactgcccc tggagcttat      240

cctggcccaa ctgcccctgg agcttatcct ggctcaactg cccctggagc cttcccaggg      300

caacctgggg cacctggggc ctaccccagt gctcctggag gctatcctgc tgctggccct      360

tatggtgtcc ccgctggacc actgacggtg ccctatgacc tgcccttgcc tggaggagtc      420

atgccccgca tgctgatcac aatcatgggc acagtgaaac ccaacgcaaa caggattgtt      480

ctagatttca ggagagggaa tgatgttgcc ttccacttta acccccgctt caatgagaac      540

aacaggagag tcattgtgtg taacacgaag caggacaata actggggaaa ggaagaaaga      600

cagtcagcct tcccctttga gagtggcaaa ccattcaaaa tacaagtcct ggttgaagct      660

gaccacttca aggttgcggt caacgatgct cacctactgc agtacaacca tcggatgaag      720

aacctccggg aaatcagcca actggggatc agtggtgaca taaccctcac cagcgctaac      780

cacgccatga tctaa                                                       795


<210>  12
<211>  264
<212>  PRT
<213>  Mus musculus

<400>  12

Met Ala Asp Ser Phe Ser Leu Asn Asp Ala Leu Ala Gly Ser Gly Asn 
1               5                   10                  15      


Pro Asn Pro Gln Gly Tyr Pro Gly Ala Trp Gly Asn Gln Pro Gly Ala 
            20                  25                  30          


Gly Gly Tyr Pro Gly Ala Ala Tyr Pro Gly Ala Tyr Pro Gly Gln Ala 
        35                  40                  45              


Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro Gly 
    50                  55                  60                  


Gln Ala Pro Pro Ser Ala Tyr Pro Gly Pro Thr Ala Pro Gly Ala Tyr 
65                  70                  75                  80  


Pro Gly Pro Thr Ala Pro Gly Ala Tyr Pro Gly Ser Thr Ala Pro Gly 
                85                  90                  95      


Ala Phe Pro Gly Gln Pro Gly Ala Pro Gly Ala Tyr Pro Ser Ala Pro 
            100                 105                 110         


Gly Gly Tyr Pro Ala Ala Gly Pro Tyr Gly Val Pro Ala Gly Pro Leu 
        115                 120                 125             


Thr Val Pro Tyr Asp Leu Pro Leu Pro Gly Gly Val Met Pro Arg Met 
    130                 135                 140                 


Leu Ile Thr Ile Met Gly Thr Val Lys Pro Asn Ala Asn Arg Ile Val 
145                 150                 155                 160 


Leu Asp Phe Arg Arg Gly Asn Asp Val Ala Phe His Phe Asn Pro Arg 
                165                 170                 175     


Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys Gln Asp 
            180                 185                 190         


Asn Asn Trp Gly Lys Glu Glu Arg Gln Ser Ala Phe Pro Phe Glu Ser 
        195                 200                 205             


Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Ala Asp His Phe Lys 
    210                 215                 220                 


Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg Met Lys 
225                 230                 235                 240 


Asn Leu Arg Glu Ile Ser Gln Leu Gly Ile Ser Gly Asp Ile Thr Leu 
                245                 250                 255     


Thr Ser Ala Asn His Ala Met Ile 
            260                 


<210>  13
<211>  1068
<212>  DNA
<213>  Homo sapiens

<400>  13
atggccttca gcggttccca ggctccctac ctgagtccag ctgtcccctt ttctgggact       60

attcaaggag gtctccagga cggacttcag atcactgtca atgggaccgt tctcagctcc      120

agtggaacca ggtttgctgt gaactttcag actggcttca gtggaaatga cattgccttc      180

cacttcaacc ctcggtttga agatggaggg tacgtggtgt gcaacacgag gcagaacgga      240

agctgggggc ccgaggagag gaagacacac atgcctttcc agaaggggat gccctttgac      300

ctctgcttcc tggtgcagag ctcagatttc aaggtgatgg tgaacgggat cctcttcgtg      360

cagtacttcc accgcgtgcc cttccaccgt gtggacacca tctccgtcaa tggctctgtg      420

cagctgtcct acatcagctt ccagaacccc cgcacagtcc ctgttcagcc tgccttctcc      480

acggtgccgt tctcccagcc tgtctgtttc ccacccaggc ccagggggcg cagacaaaaa      540

cctcccggcg tgtggcctgc caacccggct cccattaccc agacagtcat ccacacagtg      600

cagagcgccc ctggacagat gttctctact cccgccatcc cacctatgat gtacccccac      660

cccgcctatc cgatgccttt catcaccacc attctgggag ggctgtaccc atccaagtcc      720

atcctcctgt caggcactgt cctgcccagt gctcagaggt tccacatcaa cctgtgctct      780

gggaaccaca tcgccttcca cctgaacccc cgttttgatg agaatgctgt ggtccgcaac      840

acccagatcg acaactcctg ggggtctgag gagcgaagtc tgccccgaaa aatgcccttc      900

gtccgtggcc agagcttctc agtgtggatc ttgtgtgaag ctcactgcct caaggtggcc      960

gtggatggtc agcacctgtt tgaatactac catcgcctga ggaacctgcc caccatcaac     1020

agactggaag tggggggcga catccagctg acccatgtgc agacatag                  1068


<210>  14
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Phe Ser Gly Ser Gln Ala Pro Tyr Leu Ser Pro Ala Val Pro 
1               5                   10                  15      


Phe Ser Gly Thr Ile Gln Gly Gly Leu Gln Asp Gly Leu Gln Ile Thr 
            20                  25                  30          


Val Asn Gly Thr Val Leu Ser Ser Ser Gly Thr Arg Phe Ala Val Asn 
        35                  40                  45              


Phe Gln Thr Gly Phe Ser Gly Asn Asp Ile Ala Phe His Phe Asn Pro 
    50                  55                  60                  


Arg Phe Glu Asp Gly Gly Tyr Val Val Cys Asn Thr Arg Gln Asn Gly 
65                  70                  75                  80  


Ser Trp Gly Pro Glu Glu Arg Lys Thr His Met Pro Phe Gln Lys Gly 
                85                  90                  95      


Met Pro Phe Asp Leu Cys Phe Leu Val Gln Ser Ser Asp Phe Lys Val 
            100                 105                 110         


Met Val Asn Gly Ile Leu Phe Val Gln Tyr Phe His Arg Val Pro Phe 
        115                 120                 125             


His Arg Val Asp Thr Ile Ser Val Asn Gly Ser Val Gln Leu Ser Tyr 
    130                 135                 140                 


Ile Ser Phe Gln Asn Pro Arg Thr Val Pro Val Gln Pro Ala Phe Ser 
145                 150                 155                 160 


Thr Val Pro Phe Ser Gln Pro Val Cys Phe Pro Pro Arg Pro Arg Gly 
                165                 170                 175     


Arg Arg Gln Lys Pro Pro Gly Val Trp Pro Ala Asn Pro Ala Pro Ile 
            180                 185                 190         


Thr Gln Thr Val Ile His Thr Val Gln Ser Ala Pro Gly Gln Met Phe 
        195                 200                 205             


Ser Thr Pro Ala Ile Pro Pro Met Met Tyr Pro His Pro Ala Tyr Pro 
    210                 215                 220                 


Met Pro Phe Ile Thr Thr Ile Leu Gly Gly Leu Tyr Pro Ser Lys Ser 
225                 230                 235                 240 


Ile Leu Leu Ser Gly Thr Val Leu Pro Ser Ala Gln Arg Phe His Ile 
                245                 250                 255     


Asn Leu Cys Ser Gly Asn His Ile Ala Phe His Leu Asn Pro Arg Phe 
            260                 265                 270         


Asp Glu Asn Ala Val Val Arg Asn Thr Gln Ile Asp Asn Ser Trp Gly 
        275                 280                 285             


Ser Glu Glu Arg Ser Leu Pro Arg Lys Met Pro Phe Val Arg Gly Gln 
    290                 295                 300                 


Ser Phe Ser Val Trp Ile Leu Cys Glu Ala His Cys Leu Lys Val Ala 
305                 310                 315                 320 


Val Asp Gly Gln His Leu Phe Glu Tyr Tyr His Arg Leu Arg Asn Leu 
                325                 330                 335     


Pro Thr Ile Asn Arg Leu Glu Val Gly Gly Asp Ile Gln Leu Thr His 
            340                 345                 350         


Val Gln Thr 
        355 


<210>  15
<211>  972
<212>  DNA
<213>  Homo sapiens

<400>  15
atggccttca gcggttccca ggctccctac ctgagtccag ctgtcccctt ttctgggact       60

attcaaggag gtctccagga cggacttcag atcactgtca atgggaccgt tctcagctcc      120

agtggaacca ggtttgctgt gaactttcag actggcttca gtggaaatga cattgccttc      180

cacttcaacc ctcggtttga agatggaggg tacgtggtgt gcaacacgag gcagaacgga      240

agctgggggc ccgaggagag gaagacacac atgcctttcc agaaggggat gccctttgac      300

ctctgcttcc tggtgcagag ctcagatttc aaggtgatgg tgaacgggat cctcttcgtg      360

cagtacttcc accgcgtgcc cttccaccgt gtggacacca tctccgtcaa tggctctgtg      420

cagctgtcct acatcagctt ccagcctccc ggcgtgtggc ctgccaaccc ggctcccatt      480

acccagacag tcatccacac agtgcagagc gcccctggac agatgttctc tactcccgcc      540

atcccaccta tgatgtaccc ccaccccgcc tatccgatgc ctttcatcac caccattctg      600

ggagggctgt acccatccaa gtccatcctc ctgtcaggca ctgtcctgcc cagtgctcag      660

aggttccaca tcaacctgtg ctctgggaac cacatcgcct tccacctgaa cccccgtttt      720

gatgagaatg ctgtggtccg caacacccag atcgacaact cctgggggtc tgaggagcga      780

agtctgcccc gaaaaatgcc cttcgtccgt ggccagagct tctcagtgtg gatcttgtgt      840

gaagctcact gcctcaaggt ggccgtggat ggtcagcacc tgtttgaata ctaccatcgc      900

ctgaggaacc tgcccaccat caacagactg gaagtggggg gcgacatcca gctgacccat      960

gtgcagacat ag                                                          972


<210>  16
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Phe Ser Gly Ser Gln Ala Pro Tyr Leu Ser Pro Ala Val Pro 
1               5                   10                  15      


Phe Ser Gly Thr Ile Gln Gly Gly Leu Gln Asp Gly Leu Gln Ile Thr 
            20                  25                  30          


Val Asn Gly Thr Val Leu Ser Ser Ser Gly Thr Arg Phe Ala Val Asn 
        35                  40                  45              


Phe Gln Thr Gly Phe Ser Gly Asn Asp Ile Ala Phe His Phe Asn Pro 
    50                  55                  60                  


Arg Phe Glu Asp Gly Gly Tyr Val Val Cys Asn Thr Arg Gln Asn Gly 
65                  70                  75                  80  


Ser Trp Gly Pro Glu Glu Arg Lys Thr His Met Pro Phe Gln Lys Gly 
                85                  90                  95      


Met Pro Phe Asp Leu Cys Phe Leu Val Gln Ser Ser Asp Phe Lys Val 
            100                 105                 110         


Met Val Asn Gly Ile Leu Phe Val Gln Tyr Phe His Arg Val Pro Phe 
        115                 120                 125             


His Arg Val Asp Thr Ile Ser Val Asn Gly Ser Val Gln Leu Ser Tyr 
    130                 135                 140                 


Ile Ser Phe Gln Pro Pro Gly Val Trp Pro Ala Asn Pro Ala Pro Ile 
145                 150                 155                 160 


Thr Gln Thr Val Ile His Thr Val Gln Ser Ala Pro Gly Gln Met Phe 
                165                 170                 175     


Ser Thr Pro Ala Ile Pro Pro Met Met Tyr Pro His Pro Ala Tyr Pro 
            180                 185                 190         


Met Pro Phe Ile Thr Thr Ile Leu Gly Gly Leu Tyr Pro Ser Lys Ser 
        195                 200                 205             


Ile Leu Leu Ser Gly Thr Val Leu Pro Ser Ala Gln Arg Phe His Ile 
    210                 215                 220                 


Asn Leu Cys Ser Gly Asn His Ile Ala Phe His Leu Asn Pro Arg Phe 
225                 230                 235                 240 


Asp Glu Asn Ala Val Val Arg Asn Thr Gln Ile Asp Asn Ser Trp Gly 
                245                 250                 255     


Ser Glu Glu Arg Ser Leu Pro Arg Lys Met Pro Phe Val Arg Gly Gln 
            260                 265                 270         


Ser Phe Ser Val Trp Ile Leu Cys Glu Ala His Cys Leu Lys Val Ala 
        275                 280                 285             


Val Asp Gly Gln His Leu Phe Glu Tyr Tyr His Arg Leu Arg Asn Leu 
    290                 295                 300                 


Pro Thr Ile Asn Arg Leu Glu Val Gly Gly Asp Ile Gln Leu Thr His 
305                 310                 315                 320 


Val Gln Thr 
            


<210>  17
<211>  1068
<212>  DNA
<213>  Homo sapiens

<400>  17
atggccttca gcggttccca ggctccctat ctgagcccag ccgtcccctt ttctgggact       60

atccaagggg gtctccagga cggatttcag atcactgtca atggggccgt tctcagctcc      120

agtggaacca ggtttgctgt ggactttcag acgggcttca gtggaaacga cattgccttc      180

cacttcaacc ctcggtttga agacggaggg tatgtggtgt gcaacacgag gcagaaagga      240

agatgggggc ccgaggagag gaagatgcac atgcccttcc agaaggggat gccctttgac      300

ctctgcttcc tggtgcagag ctcagatttc aaggtgatgg tgaacgggag cctcttcgtg      360

cagtacttcc accgcgtgcc cttccaccgt gtggacacca tctccgtcaa tggctctgtg      420

cagctgtcct acatcagctt ccagaatccc cgcacagtcc ccgttcagcc tgccttctcc      480

acggtgccgt tctcccagcc tgtctgtttc ccacccaggc ccagggggcg cagacaaaaa      540

cctcccagcg tgcggcctgc caacccagct cccattaccc agacagtcat ccacacggtg      600

cagagcgcct ctggacagat gttctctact cccgccatcc cacctatgat gtacccccac      660

cctgcctatc cgatgccttt catcaccacc attccgggag ggctgtaccc atccaagtcc      720

atcatcctgt caggcactgt cctgcccagt gctcagaggt tccacatcaa cctgtgctct      780

gggagccaca tcgccttcca catgaacccc cgttttgatg agaatgctgt ggtccgtaac      840

acccagatca acaactcttg ggggtctgag gagcgaagtc tgccccgaaa aatgcccttc      900

gtccgaggcc agagcttctc ggtgtggatc ttgtgtgaag ctcactgcct caaggtggcc      960

gtggatggtc agcacgtgtt tgaatactac catcgcctga ggaacctgcc caccatcaac     1020

aaactggaag tgggtggcga catccagctg acccacgtgc agacatag                  1068


<210>  18
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Phe Ser Gly Ser Gln Ala Pro Tyr Leu Ser Pro Ala Val Pro 
1               5                   10                  15      


Phe Ser Gly Thr Ile Gln Gly Gly Leu Gln Asp Gly Phe Gln Ile Thr 
            20                  25                  30          


Val Asn Gly Ala Val Leu Ser Ser Ser Gly Thr Arg Phe Ala Val Asp 
        35                  40                  45              


Phe Gln Thr Gly Phe Ser Gly Asn Asp Ile Ala Phe His Phe Asn Pro 
    50                  55                  60                  


Arg Phe Glu Asp Gly Gly Tyr Val Val Cys Asn Thr Arg Gln Lys Gly 
65                  70                  75                  80  


Arg Trp Gly Pro Glu Glu Arg Lys Met His Met Pro Phe Gln Lys Gly 
                85                  90                  95      


Met Pro Phe Asp Leu Cys Phe Leu Val Gln Ser Ser Asp Phe Lys Val 
            100                 105                 110         


Met Val Asn Gly Ser Leu Phe Val Gln Tyr Phe His Arg Val Pro Phe 
        115                 120                 125             


His Arg Val Asp Thr Ile Ser Val Asn Gly Ser Val Gln Leu Ser Tyr 
    130                 135                 140                 


Ile Ser Phe Gln Asn Pro Arg Thr Val Pro Val Gln Pro Ala Phe Ser 
145                 150                 155                 160 


Thr Val Pro Phe Ser Gln Pro Val Cys Phe Pro Pro Arg Pro Arg Gly 
                165                 170                 175     


Arg Arg Gln Lys Pro Pro Ser Val Arg Pro Ala Asn Pro Ala Pro Ile 
            180                 185                 190         


Thr Gln Thr Val Ile His Thr Val Gln Ser Ala Ser Gly Gln Met Phe 
        195                 200                 205             


Ser Thr Pro Ala Ile Pro Pro Met Met Tyr Pro His Pro Ala Tyr Pro 
    210                 215                 220                 


Met Pro Phe Ile Thr Thr Ile Pro Gly Gly Leu Tyr Pro Ser Lys Ser 
225                 230                 235                 240 


Ile Ile Leu Ser Gly Thr Val Leu Pro Ser Ala Gln Arg Phe His Ile 
                245                 250                 255     


Asn Leu Cys Ser Gly Ser His Ile Ala Phe His Met Asn Pro Arg Phe 
            260                 265                 270         


Asp Glu Asn Ala Val Val Arg Asn Thr Gln Ile Asn Asn Ser Trp Gly 
        275                 280                 285             


Ser Glu Glu Arg Ser Leu Pro Arg Lys Met Pro Phe Val Arg Gly Gln 
    290                 295                 300                 


Ser Phe Ser Val Trp Ile Leu Cys Glu Ala His Cys Leu Lys Val Ala 
305                 310                 315                 320 


Val Asp Gly Gln His Val Phe Glu Tyr Tyr His Arg Leu Arg Asn Leu 
                325                 330                 335     


Pro Thr Ile Asn Lys Leu Glu Val Gly Gly Asp Ile Gln Leu Thr His 
            340                 345                 350         


Val Gln Thr 
        355 


<210>  19
<211>  1071
<212>  DNA
<213>  Homo sapiens

<400>  19
atggccttca gcggttgcca ggctccctat ctgagcccag ccgtcccctt ttctgggact       60

atccaagggg gtctccagga cggatttcag atcactgtca atggggccgt tctcagctgc      120

agtggaacca ggtttgctgt ggactttcag acgggcttca gtggaaacga cattgccttc      180

cacttcaacc ctcggtttga agacggaggg tatgtggtgt gcaacacgag gcagaaagga      240

acatgggggc ccgaggagag gaagatgcac atgcccttcc agaaggggat gccctttgac      300

ctctgcttcc tggtgcagag ctcagatttc aaggtgatgg tgaacgggag cctcttcgtg      360

cagtacttcc accgcgtgcc cttccaccgt gtggacacca tctccgtcaa tggctctgtg      420

cagctgtcct acatcagctt ccagaatccc cgcgcagtcc ccgttcagcc tgccttctcc      480

acggtgccgt tctcccagcc tgtctgtttc ccacccaggc ccagggggcg cagacaaaaa      540

cctcccagcg tgcggcctgc caacccagct cccattaccc agacagtcat ccacacggtg      600

cagagtgcct ctggacagat gttctctcag actcccgcca tcccacctat gatgtacccc      660

caccctgcct atccgatgcc tttcatcacc accattccgg gagggctgta cccatccaag      720

tccatcatcc tgtcaggcac tgtcctgccc agtgctcaga ggttccacat caacctgtgc      780

tctgggagcc acatcgcctt ccacatgaac ccccgttttg atgagaatgc tgtggtccgt      840

aacacccaga tcaacaactc ttgggggtct gaggagcgaa gtctgccccg aaaaatgccc      900

ttcgtccgag gccagagctt ctcggtgtgg atcttgtgtg aagctcactg cctcaaggtg      960

gccgtggatg gtcagcacgt gtttgaatac taccatcgcc tgaggaacct gcccaccatc     1020

aacaaactgg aagtgggtgg cgacatccag ctgacccacg tgcagacata g              1071


<210>  20
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Phe Ser Gly Cys Gln Ala Pro Tyr Leu Ser Pro Ala Val Pro 
1               5                   10                  15      


Phe Ser Gly Thr Ile Gln Gly Gly Leu Gln Asp Gly Phe Gln Ile Thr 
            20                  25                  30          


Val Asn Gly Ala Val Leu Ser Cys Ser Gly Thr Arg Phe Ala Val Asp 
        35                  40                  45              


Phe Gln Thr Gly Phe Ser Gly Asn Asp Ile Ala Phe His Phe Asn Pro 
    50                  55                  60                  


Arg Phe Glu Asp Gly Gly Tyr Val Val Cys Asn Thr Arg Gln Lys Gly 
65                  70                  75                  80  


Thr Trp Gly Pro Glu Glu Arg Lys Met His Met Pro Phe Gln Lys Gly 
                85                  90                  95      


Met Pro Phe Asp Leu Cys Phe Leu Val Gln Ser Ser Asp Phe Lys Val 
            100                 105                 110         


Met Val Asn Gly Ser Leu Phe Val Gln Tyr Phe His Arg Val Pro Phe 
        115                 120                 125             


His Arg Val Asp Thr Ile Ser Val Asn Gly Ser Val Gln Leu Ser Tyr 
    130                 135                 140                 


Ile Ser Phe Gln Asn Pro Arg Ala Val Pro Val Gln Pro Ala Phe Ser 
145                 150                 155                 160 


Thr Val Pro Phe Ser Gln Pro Val Cys Phe Pro Pro Arg Pro Arg Gly 
                165                 170                 175     


Arg Arg Gln Lys Pro Pro Ser Val Arg Pro Ala Asn Pro Ala Pro Ile 
            180                 185                 190         


Thr Gln Thr Val Ile His Thr Val Gln Ser Ala Ser Gly Gln Met Phe 
        195                 200                 205             


Ser Gln Thr Pro Ala Ile Pro Pro Met Met Tyr Pro His Pro Ala Tyr 
    210                 215                 220                 


Pro Met Pro Phe Ile Thr Thr Ile Pro Gly Gly Leu Tyr Pro Ser Lys 
225                 230                 235                 240 


Ser Ile Ile Leu Ser Gly Thr Val Leu Pro Ser Ala Gln Arg Phe His 
                245                 250                 255     


Ile Asn Leu Cys Ser Gly Ser His Ile Ala Phe His Met Asn Pro Arg 
            260                 265                 270         


Phe Asp Glu Asn Ala Val Val Arg Asn Thr Gln Ile Asn Asn Ser Trp 
        275                 280                 285             


Gly Ser Glu Glu Arg Ser Leu Pro Arg Lys Met Pro Phe Val Arg Gly 
    290                 295                 300                 


Gln Ser Phe Ser Val Trp Ile Leu Cys Glu Ala His Cys Leu Lys Val 
305                 310                 315                 320 


Ala Val Asp Gly Gln His Val Phe Glu Tyr Tyr His Arg Leu Arg Asn 
                325                 330                 335     


Leu Pro Thr Ile Asn Lys Leu Glu Val Gly Gly Asp Ile Gln Leu Thr 
            340                 345                 350         


His Val Gln Thr 
        355     


<210>  21
<211>  1062
<212>  DNA
<213>  Mus musculus

<400>  21
atggctctct tcagtgccca gtctccatac attaacccga tcatcccctt tactggacca       60

atccaaggag ggctgcagga gggacttcag gtgaccctcc aggggactac caagagtttt      120

gcacaaaggt ttgtggtgaa ctttcagaac agcttcaatg gaaatgacat tgccttccac      180

ttcaaccccc ggtttgagga aggagggtat gtggtttgca acacgaagca gaacggacag      240

tggggtcctg aggagagaaa gatgcagatg cccttccaga aggggatgcc ctttgagctt      300

tgcttcctgg tgcagaggtc agagttcaag gtgatggtga acaagaaatt ctttgtgcag      360

taccaacacc gcgtacccta ccacctcgtg gacaccatcg ctgtctccgg ctgcttgaag      420

ctgtccttta tcaccttcca gaactctgca gcccctgtcc agcatgtctt ctccacagtg      480

cagttctctc agccagtcca gttcccacgg acccctaagg ggcgcaaaca gaaaactcag      540

aactttcgtc ctgcccacca ggcacccatg gctcaaacta ccatccatat ggttcacagc      600

acccctggac agatgttctc tactcctgga atccctcctg tggtgtaccc caccccagcc      660

tataccatac ctttctacac ccccattcca aatgggcttt acccgtccaa gtccatcatg      720

atatcaggca atgtcttgcc agatgctacg aggttccata tcaaccttcg ctgtggaggt      780

gacattgctt tccacctgaa cccccgtttc aatgagaatg ctgttgtccg aaacactcag      840

atcaacaact cctgggggca ggaagagcga agtctgcttg ggaggatgcc cttcagtcga      900

ggccagagct tctcggtgtg gatcatatgt gaaggtcact gcttcaaggt agctgtgaat      960

ggtcaacaca tgtgtgaata ttaccaccgc ctgaagaact tgcaggatat caacactcta     1020

gaagtggcgg gtgatatcca gctgacccac gtgcagacat ag                        1062


<210>  22
<211>  353
<212>  PRT
<213>  Mus musculus

<400>  22

Met Ala Leu Phe Ser Ala Gln Ser Pro Tyr Ile Asn Pro Ile Ile Pro 
1               5                   10                  15      


Phe Thr Gly Pro Ile Gln Gly Gly Leu Gln Glu Gly Leu Gln Val Thr 
            20                  25                  30          


Leu Gln Gly Thr Thr Lys Ser Phe Ala Gln Arg Phe Val Val Asn Phe 
        35                  40                  45              


Gln Asn Ser Phe Asn Gly Asn Asp Ile Ala Phe His Phe Asn Pro Arg 
    50                  55                  60                  


Phe Glu Glu Gly Gly Tyr Val Val Cys Asn Thr Lys Gln Asn Gly Gln 
65                  70                  75                  80  


Trp Gly Pro Glu Glu Arg Lys Met Gln Met Pro Phe Gln Lys Gly Met 
                85                  90                  95      


Pro Phe Glu Leu Cys Phe Leu Val Gln Arg Ser Glu Phe Lys Val Met 
            100                 105                 110         


Val Asn Lys Lys Phe Phe Val Gln Tyr Gln His Arg Val Pro Tyr His 
        115                 120                 125             


Leu Val Asp Thr Ile Ala Val Ser Gly Cys Leu Lys Leu Ser Phe Ile 
    130                 135                 140                 


Thr Phe Gln Asn Ser Ala Ala Pro Val Gln His Val Phe Ser Thr Val 
145                 150                 155                 160 


Gln Phe Ser Gln Pro Val Gln Phe Pro Arg Thr Pro Lys Gly Arg Lys 
                165                 170                 175     


Gln Lys Thr Gln Asn Phe Arg Pro Ala His Gln Ala Pro Met Ala Gln 
            180                 185                 190         


Thr Thr Ile His Met Val His Ser Thr Pro Gly Gln Met Phe Ser Thr 
        195                 200                 205             


Pro Gly Ile Pro Pro Val Val Tyr Pro Thr Pro Ala Tyr Thr Ile Pro 
    210                 215                 220                 


Phe Tyr Thr Pro Ile Pro Asn Gly Leu Tyr Pro Ser Lys Ser Ile Met 
225                 230                 235                 240 


Ile Ser Gly Asn Val Leu Pro Asp Ala Thr Arg Phe His Ile Asn Leu 
                245                 250                 255     


Arg Cys Gly Gly Asp Ile Ala Phe His Leu Asn Pro Arg Phe Asn Glu 
            260                 265                 270         


Asn Ala Val Val Arg Asn Thr Gln Ile Asn Asn Ser Trp Gly Gln Glu 
        275                 280                 285             


Glu Arg Ser Leu Leu Gly Arg Met Pro Phe Ser Arg Gly Gln Ser Phe 
    290                 295                 300                 


Ser Val Trp Ile Ile Cys Glu Gly His Cys Phe Lys Val Ala Val Asn 
305                 310                 315                 320 


Gly Gln His Met Cys Glu Tyr Tyr His Arg Leu Lys Asn Leu Gln Asp 
                325                 330                 335     


Ile Asn Thr Leu Glu Val Ala Gly Asp Ile Gln Leu Thr His Val Gln 
            340                 345                 350         


Thr 
    


<210>  23
<211>  969
<212>  DNA
<213>  Mus musculus

<400>  23
atggctctct tcagtgccca gtctccatac attaacccga tcatcccctt tactggacca       60

atccaaggag ggctgcagga gggacttcag gtgaccctcc aggggactac caagagtttt      120

gcacaaaggt ttgtggtgaa ctttcagaac agcttcaatg gaaatgacat tgccttccac      180

ttcaaccccc ggtttgagga aggagggtat gtggtttgca acacgaagca gaacggacag      240

tggggtcctg aggagagaaa gatgcagatg cccttccaga aggggatgcc ctttgagctt      300

tgcttcctgg tgcagaggtc agagttcaag gtgatggtga acaagaaatt ctttgtgcag      360

taccaacacc gcgtacccta ccacctcgtg gacaccatcg ctgtctccgg ctgcttgaag      420

ctgtccttta tcaccttcca gactcagaac tttcgtcctg cccaccaggc acccatggct      480

caaactacca tccatatggt tcacagcacc cctggacaga tgttctctac tcctggaatc      540

cctcctgtgg tgtaccccac cccagcctat accatacctt tctacacccc cattccaaat      600

gggctttacc cgtccaagtc catcatgata tcaggcaatg tcttgccaga tgctacgagg      660

ttccatatca accttcgctg tggaggtgac attgctttcc acctgaaccc ccgtttcaat      720

gagaatgctg ttgtccgaaa cactcagatc aacaactcct gggggcagga agagcgaagt      780

ctgcttggga ggatgccctt cagtcgaggc cagagcttct cggtgtggat catatgtgaa      840

ggtcactgct tcaaggtagc tgtgaatggt caacacatgt gtgaatatta ccaccgcctg      900

aagaacttgc aggatatcaa cactctagaa gtggcgggtg atatccagct gacccacgtg      960

cagacatag                                                              969


<210>  24
<211>  322
<212>  PRT
<213>  Mus musculus

<400>  24

Met Ala Leu Phe Ser Ala Gln Ser Pro Tyr Ile Asn Pro Ile Ile Pro 
1               5                   10                  15      


Phe Thr Gly Pro Ile Gln Gly Gly Leu Gln Glu Gly Leu Gln Val Thr 
            20                  25                  30          


Leu Gln Gly Thr Thr Lys Ser Phe Ala Gln Arg Phe Val Val Asn Phe 
        35                  40                  45              


Gln Asn Ser Phe Asn Gly Asn Asp Ile Ala Phe His Phe Asn Pro Arg 
    50                  55                  60                  


Phe Glu Glu Gly Gly Tyr Val Val Cys Asn Thr Lys Gln Asn Gly Gln 
65                  70                  75                  80  


Trp Gly Pro Glu Glu Arg Lys Met Gln Met Pro Phe Gln Lys Gly Met 
                85                  90                  95      


Pro Phe Glu Leu Cys Phe Leu Val Gln Arg Ser Glu Phe Lys Val Met 
            100                 105                 110         


Val Asn Lys Lys Phe Phe Val Gln Tyr Gln His Arg Val Pro Tyr His 
        115                 120                 125             


Leu Val Asp Thr Ile Ala Val Ser Gly Cys Leu Lys Leu Ser Phe Ile 
    130                 135                 140                 


Thr Phe Gln Thr Gln Asn Phe Arg Pro Ala His Gln Ala Pro Met Ala 
145                 150                 155                 160 


Gln Thr Thr Ile His Met Val His Ser Thr Pro Gly Gln Met Phe Ser 
                165                 170                 175     


Thr Pro Gly Ile Pro Pro Val Val Tyr Pro Thr Pro Ala Tyr Thr Ile 
            180                 185                 190         


Pro Phe Tyr Thr Pro Ile Pro Asn Gly Leu Tyr Pro Ser Lys Ser Ile 
        195                 200                 205             


Met Ile Ser Gly Asn Val Leu Pro Asp Ala Thr Arg Phe His Ile Asn 
    210                 215                 220                 


Leu Arg Cys Gly Gly Asp Ile Ala Phe His Leu Asn Pro Arg Phe Asn 
225                 230                 235                 240 


Glu Asn Ala Val Val Arg Asn Thr Gln Ile Asn Asn Ser Trp Gly Gln 
                245                 250                 255     


Glu Glu Arg Ser Leu Leu Gly Arg Met Pro Phe Ser Arg Gly Gln Ser 
            260                 265                 270         


Phe Ser Val Trp Ile Ile Cys Glu Gly His Cys Phe Lys Val Ala Val 
        275                 280                 285             


Asn Gly Gln His Met Cys Glu Tyr Tyr His Arg Leu Lys Asn Leu Gln 
    290                 295                 300                 


Asp Ile Asn Thr Leu Glu Val Ala Gly Asp Ile Gln Leu Thr His Val 
305                 310                 315                 320 


Gln Thr 
        


<210>  25
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Gal-1 sense synthetic 
       primer"

<400>  25
cgcgaacaga ttggaggtgc ttgtggtctg gtcgccagca ac                          42


<210>  26
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Gal-1 antisense 
       synthetic primer"

<400>  26
gtggcggccg ctctattagt caaaggccac acatttgatc tt                          42


<210>  27
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Gal-3 sense synthetic 
       primer"

<400>  27
cgcgaacaga ttggaggtgc agacaatttt tcgctccatg at                          42


<210>  28
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Gal-3 antisense 
       synthetic primer"

<400>  28
gtggcggccg ctctattagt atcatggtat atgaagcact ggt                         43