                         SEQUENCE LISTING

<110>  DuPont Nutrition Biosciences ApS
 
<120>  METHOD

<130>  P105953PCT

<150>  GB 1419900.4
<151>  2014-11-07

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  887
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated lactase fragment

<400>  1

Val Glu Asp Ala Thr Arg Ser Asp Ser Thr Thr Gln Met Ser Ser Thr 
1               5                   10                  15      


Pro Glu Val Val Tyr Ser Ser Ala Val Asp Ser Lys Gln Asn Arg Thr 
            20                  25                  30          


Ser Asp Phe Asp Ala Asn Trp Lys Phe Met Leu Ser Asp Ser Val Gln 
        35                  40                  45              


Ala Gln Asp Pro Ala Phe Asp Asp Ser Ala Trp Gln Gln Val Asp Leu 
    50                  55                  60                  


Pro His Asp Tyr Ser Ile Thr Gln Lys Tyr Ser Gln Ser Asn Glu Ala 
65                  70                  75                  80  


Glu Ser Ala Tyr Leu Pro Gly Gly Thr Gly Trp Tyr Arg Lys Ser Phe 
                85                  90                  95      


Thr Ile Asp Arg Asp Leu Ala Gly Lys Arg Ile Ala Ile Asn Phe Asp 
            100                 105                 110         


Gly Val Tyr Met Asn Ala Thr Val Trp Phe Asn Gly Val Lys Leu Gly 
        115                 120                 125             


Thr His Pro Tyr Gly Tyr Ser Pro Phe Ser Phe Asp Leu Thr Gly Asn 
    130                 135                 140                 


Ala Lys Phe Gly Gly Glu Asn Thr Ile Val Val Lys Val Glu Asn Arg 
145                 150                 155                 160 


Leu Pro Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val 
                165                 170                 175     


Thr Leu Thr Val Thr Asp Gly Val His Val Gly Asn Asn Gly Val Ala 
            180                 185                 190         


Ile Lys Thr Pro Ser Leu Ala Thr Gln Asn Gly Gly Asp Val Thr Met 
        195                 200                 205             


Asn Leu Thr Thr Lys Val Ala Asn Asp Thr Glu Ala Ala Ala Asn Ile 
    210                 215                 220                 


Thr Leu Lys Gln Thr Val Phe Pro Lys Gly Gly Lys Thr Asp Ala Ala 
225                 230                 235                 240 


Ile Gly Thr Val Thr Thr Ala Ser Lys Ser Ile Ala Ala Gly Ala Ser 
                245                 250                 255     


Ala Asp Val Thr Ser Thr Ile Thr Ala Ala Ser Pro Lys Leu Trp Ser 
            260                 265                 270         


Ile Lys Asn Pro Asn Leu Tyr Thr Val Arg Thr Glu Val Leu Asn Gly 
        275                 280                 285             


Gly Lys Val Leu Asp Thr Tyr Asp Thr Glu Tyr Gly Phe Arg Trp Thr 
    290                 295                 300                 


Gly Phe Asp Ala Thr Ser Gly Phe Ser Leu Asn Gly Glu Lys Val Lys 
305                 310                 315                 320 


Leu Lys Gly Val Ser Met His His Asp Gln Gly Ser Leu Gly Ala Val 
                325                 330                 335     


Ala Asn Arg Arg Ala Ile Glu Arg Gln Val Glu Ile Leu Gln Lys Met 
            340                 345                 350         


Gly Val Asn Ser Ile Arg Thr Thr His Asn Pro Ala Ala Lys Ala Leu 
        355                 360                 365             


Ile Asp Val Cys Asn Glu Lys Gly Val Leu Val Val Glu Glu Val Phe 
    370                 375                 380                 


Asp Met Trp Asn Arg Ser Lys Asn Gly Asn Thr Glu Asp Tyr Gly Lys 
385                 390                 395                 400 


Trp Phe Gly Gln Ala Ile Ala Gly Asp Asn Ala Val Leu Gly Gly Asp 
                405                 410                 415     


Lys Asp Glu Thr Trp Ala Lys Phe Asp Leu Thr Ser Thr Ile Asn Arg 
            420                 425                 430         


Asp Arg Asn Ala Pro Ser Val Ile Met Trp Ser Leu Gly Asn Glu Met 
        435                 440                 445             


Met Glu Gly Ile Ser Gly Ser Val Ser Gly Phe Pro Ala Thr Ser Ala 
    450                 455                 460                 


Lys Leu Val Ala Trp Thr Lys Ala Ala Asp Ser Thr Arg Pro Met Thr 
465                 470                 475                 480 


Tyr Gly Asp Asn Lys Ile Lys Ala Asn Trp Asn Glu Ser Asn Thr Met 
                485                 490                 495     


Gly Asp Asn Leu Thr Ala Asn Gly Gly Val Val Gly Thr Asn Tyr Ser 
            500                 505                 510         


Asp Gly Ala Asn Tyr Asp Lys Ile Arg Thr Thr His Pro Ser Trp Ala 
        515                 520                 525             


Ile Tyr Gly Ser Glu Thr Ala Ser Ala Ile Asn Ser Arg Gly Ile Tyr 
    530                 535                 540                 


Asn Arg Thr Thr Gly Gly Ala Gln Ser Ser Asp Lys Gln Leu Thr Ser 
545                 550                 555                 560 


Tyr Asp Asn Ser Ala Val Gly Trp Gly Ala Val Ala Ser Ser Ala Trp 
                565                 570                 575     


Tyr Asp Val Val Gln Arg Asp Phe Val Ala Gly Thr Tyr Val Trp Thr 
            580                 585                 590         


Gly Phe Asp Tyr Leu Gly Glu Pro Thr Pro Trp Asn Gly Thr Gly Ser 
        595                 600                 605             


Gly Ala Val Gly Ser Trp Pro Ser Pro Lys Asn Ser Tyr Phe Gly Ile 
    610                 615                 620                 


Val Asp Thr Ala Gly Phe Pro Lys Asp Thr Tyr Tyr Phe Tyr Gln Ser 
625                 630                 635                 640 


Gln Trp Asn Asp Asp Val His Thr Leu His Ile Leu Pro Ala Trp Asn 
                645                 650                 655     


Glu Asn Val Val Ala Lys Gly Ser Gly Asn Asn Val Pro Val Val Val 
            660                 665                 670         


Tyr Thr Asp Ala Ala Lys Val Lys Leu Tyr Phe Thr Pro Lys Gly Ser 
        675                 680                 685             


Thr Glu Lys Arg Leu Ile Gly Glu Lys Ser Phe Thr Lys Lys Thr Thr 
    690                 695                 700                 


Ala Ala Gly Tyr Thr Tyr Gln Val Tyr Glu Gly Ser Asp Lys Asp Ser 
705                 710                 715                 720 


Thr Ala His Lys Asn Met Tyr Leu Thr Trp Asn Val Pro Trp Ala Glu 
                725                 730                 735     


Gly Thr Ile Ser Ala Glu Ala Tyr Asp Glu Asn Asn Arg Leu Ile Pro 
            740                 745                 750         


Glu Gly Ser Thr Glu Gly Asn Ala Ser Val Thr Thr Thr Gly Lys Ala 
        755                 760                 765             


Ala Lys Leu Lys Ala Asp Ala Asp Arg Lys Thr Ile Thr Ala Asp Gly 
    770                 775                 780                 


Lys Asp Leu Ser Tyr Ile Glu Val Asp Val Thr Asp Ala Asn Gly His 
785                 790                 795                 800 


Ile Val Pro Asp Ala Ala Asn Arg Val Thr Phe Asp Val Lys Gly Ala 
                805                 810                 815     


Gly Lys Leu Val Gly Val Asp Asn Gly Ser Ser Pro Asp His Asp Ser 
            820                 825                 830         


Tyr Gln Ala Asp Asn Arg Lys Ala Phe Ser Gly Lys Val Leu Ala Ile 
        835                 840                 845             


Val Gln Ser Thr Lys Glu Ala Gly Glu Ile Thr Val Thr Ala Lys Ala 
    850                 855                 860                 


Asp Gly Leu Gln Ser Ser Thr Val Lys Ile Ala Thr Thr Ala Val Pro 
865                 870                 875                 880 


Gly Thr Ser Thr Glu Lys Thr 
                885         


<210>  2
<211>  965
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated lactase fragment

<400>  2

Val Glu Asp Ala Thr Arg Ser Asp Ser Thr Thr Gln Met Ser Ser Thr 
1               5                   10                  15      


Pro Glu Val Val Tyr Ser Ser Ala Val Asp Ser Lys Gln Asn Arg Thr 
            20                  25                  30          


Ser Asp Phe Asp Ala Asn Trp Lys Phe Met Leu Ser Asp Ser Val Gln 
        35                  40                  45              


Ala Gln Asp Pro Ala Phe Asp Asp Ser Ala Trp Gln Gln Val Asp Leu 
    50                  55                  60                  


Pro His Asp Tyr Ser Ile Thr Gln Lys Tyr Ser Gln Ser Asn Glu Ala 
65                  70                  75                  80  


Glu Ser Ala Tyr Leu Pro Gly Gly Thr Gly Trp Tyr Arg Lys Ser Phe 
                85                  90                  95      


Thr Ile Asp Arg Asp Leu Ala Gly Lys Arg Ile Ala Ile Asn Phe Asp 
            100                 105                 110         


Gly Val Tyr Met Asn Ala Thr Val Trp Phe Asn Gly Val Lys Leu Gly 
        115                 120                 125             


Thr His Pro Tyr Gly Tyr Ser Pro Phe Ser Phe Asp Leu Thr Gly Asn 
    130                 135                 140                 


Ala Lys Phe Gly Gly Glu Asn Thr Ile Val Val Lys Val Glu Asn Arg 
145                 150                 155                 160 


Leu Pro Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val 
                165                 170                 175     


Thr Leu Thr Val Thr Asp Gly Val His Val Gly Asn Asn Gly Val Ala 
            180                 185                 190         


Ile Lys Thr Pro Ser Leu Ala Thr Gln Asn Gly Gly Asp Val Thr Met 
        195                 200                 205             


Asn Leu Thr Thr Lys Val Ala Asn Asp Thr Glu Ala Ala Ala Asn Ile 
    210                 215                 220                 


Thr Leu Lys Gln Thr Val Phe Pro Lys Gly Gly Lys Thr Asp Ala Ala 
225                 230                 235                 240 


Ile Gly Thr Val Thr Thr Ala Ser Lys Ser Ile Ala Ala Gly Ala Ser 
                245                 250                 255     


Ala Asp Val Thr Ser Thr Ile Thr Ala Ala Ser Pro Lys Leu Trp Ser 
            260                 265                 270         


Ile Lys Asn Pro Asn Leu Tyr Thr Val Arg Thr Glu Val Leu Asn Gly 
        275                 280                 285             


Gly Lys Val Leu Asp Thr Tyr Asp Thr Glu Tyr Gly Phe Arg Trp Thr 
    290                 295                 300                 


Gly Phe Asp Ala Thr Ser Gly Phe Ser Leu Asn Gly Glu Lys Val Lys 
305                 310                 315                 320 


Leu Lys Gly Val Ser Met His His Asp Gln Gly Ser Leu Gly Ala Val 
                325                 330                 335     


Ala Asn Arg Arg Ala Ile Glu Arg Gln Val Glu Ile Leu Gln Lys Met 
            340                 345                 350         


Gly Val Asn Ser Ile Arg Thr Thr His Asn Pro Ala Ala Lys Ala Leu 
        355                 360                 365             


Ile Asp Val Cys Asn Glu Lys Gly Val Leu Val Val Glu Glu Val Phe 
    370                 375                 380                 


Asp Met Trp Asn Arg Ser Lys Asn Gly Asn Thr Glu Asp Tyr Gly Lys 
385                 390                 395                 400 


Trp Phe Gly Gln Ala Ile Ala Gly Asp Asn Ala Val Leu Gly Gly Asp 
                405                 410                 415     


Lys Asp Glu Thr Trp Ala Lys Phe Asp Leu Thr Ser Thr Ile Asn Arg 
            420                 425                 430         


Asp Arg Asn Ala Pro Ser Val Ile Met Trp Ser Leu Gly Asn Glu Met 
        435                 440                 445             


Met Glu Gly Ile Ser Gly Ser Val Ser Gly Phe Pro Ala Thr Ser Ala 
    450                 455                 460                 


Lys Leu Val Ala Trp Thr Lys Ala Ala Asp Ser Thr Arg Pro Met Thr 
465                 470                 475                 480 


Tyr Gly Asp Asn Lys Ile Lys Ala Asn Trp Asn Glu Ser Asn Thr Met 
                485                 490                 495     


Gly Asp Asn Leu Thr Ala Asn Gly Gly Val Val Gly Thr Asn Tyr Ser 
            500                 505                 510         


Asp Gly Ala Asn Tyr Asp Lys Ile Arg Thr Thr His Pro Ser Trp Ala 
        515                 520                 525             


Ile Tyr Gly Ser Glu Thr Ala Ser Ala Ile Asn Ser Arg Gly Ile Tyr 
    530                 535                 540                 


Asn Arg Thr Thr Gly Gly Ala Gln Ser Ser Asp Lys Gln Leu Thr Ser 
545                 550                 555                 560 


Tyr Asp Asn Ser Ala Val Gly Trp Gly Ala Val Ala Ser Ser Ala Trp 
                565                 570                 575     


Tyr Asp Val Val Gln Arg Asp Phe Val Ala Gly Thr Tyr Val Trp Thr 
            580                 585                 590         


Gly Phe Asp Tyr Leu Gly Glu Pro Thr Pro Trp Asn Gly Thr Gly Ser 
        595                 600                 605             


Gly Ala Val Gly Ser Trp Pro Ser Pro Lys Asn Ser Tyr Phe Gly Ile 
    610                 615                 620                 


Val Asp Thr Ala Gly Phe Pro Lys Asp Thr Tyr Tyr Phe Tyr Gln Ser 
625                 630                 635                 640 


Gln Trp Asn Asp Asp Val His Thr Leu His Ile Leu Pro Ala Trp Asn 
                645                 650                 655     


Glu Asn Val Val Ala Lys Gly Ser Gly Asn Asn Val Pro Val Val Val 
            660                 665                 670         


Tyr Thr Asp Ala Ala Lys Val Lys Leu Tyr Phe Thr Pro Lys Gly Ser 
        675                 680                 685             


Thr Glu Lys Arg Leu Ile Gly Glu Lys Ser Phe Thr Lys Lys Thr Thr 
    690                 695                 700                 


Ala Ala Gly Tyr Thr Tyr Gln Val Tyr Glu Gly Ser Asp Lys Asp Ser 
705                 710                 715                 720 


Thr Ala His Lys Asn Met Tyr Leu Thr Trp Asn Val Pro Trp Ala Glu 
                725                 730                 735     


Gly Thr Ile Ser Ala Glu Ala Tyr Asp Glu Asn Asn Arg Leu Ile Pro 
            740                 745                 750         


Glu Gly Ser Thr Glu Gly Asn Ala Ser Val Thr Thr Thr Gly Lys Ala 
        755                 760                 765             


Ala Lys Leu Lys Ala Asp Ala Asp Arg Lys Thr Ile Thr Ala Asp Gly 
    770                 775                 780                 


Lys Asp Leu Ser Tyr Ile Glu Val Asp Val Thr Asp Ala Asn Gly His 
785                 790                 795                 800 


Ile Val Pro Asp Ala Ala Asn Arg Val Thr Phe Asp Val Lys Gly Ala 
                805                 810                 815     


Gly Lys Leu Val Gly Val Asp Asn Gly Ser Ser Pro Asp His Asp Ser 
            820                 825                 830         


Tyr Gln Ala Asp Asn Arg Lys Ala Phe Ser Gly Lys Val Leu Ala Ile 
        835                 840                 845             


Val Gln Ser Thr Lys Glu Ala Gly Glu Ile Thr Val Thr Ala Lys Ala 
    850                 855                 860                 


Asp Gly Leu Gln Ser Ser Thr Val Lys Ile Ala Thr Thr Ala Val Pro 
865                 870                 875                 880 


Gly Thr Ser Thr Glu Lys Thr Val Arg Ser Phe Tyr Tyr Ser Arg Asn 
                885                 890                 895     


Tyr Tyr Val Lys Thr Gly Asn Lys Pro Ile Leu Pro Ser Asp Val Glu 
            900                 905                 910         


Val Arg Tyr Ser Asp Gly Thr Ser Asp Arg Gln Asn Val Thr Trp Asp 
        915                 920                 925             


Ala Val Ser Asp Asp Gln Ile Ala Lys Ala Gly Ser Phe Ser Val Ala 
    930                 935                 940                 


Gly Thr Val Ala Gly Gln Lys Ile Ser Val Arg Val Thr Met Ile Asp 
945                 950                 955                 960 


Glu Ile Gly Ala Leu 
                965 


<210>  3
<211>  1038
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated lactase fragment

<400>  3

Val Glu Asp Ala Thr Arg Ser Asp Ser Thr Thr Gln Met Ser Ser Thr 
1               5                   10                  15      


Pro Glu Val Val Tyr Ser Ser Ala Val Asp Ser Lys Gln Asn Arg Thr 
            20                  25                  30          


Ser Asp Phe Asp Ala Asn Trp Lys Phe Met Leu Ser Asp Ser Val Gln 
        35                  40                  45              


Ala Gln Asp Pro Ala Phe Asp Asp Ser Ala Trp Gln Gln Val Asp Leu 
    50                  55                  60                  


Pro His Asp Tyr Ser Ile Thr Gln Lys Tyr Ser Gln Ser Asn Glu Ala 
65                  70                  75                  80  


Glu Ser Ala Tyr Leu Pro Gly Gly Thr Gly Trp Tyr Arg Lys Ser Phe 
                85                  90                  95      


Thr Ile Asp Arg Asp Leu Ala Gly Lys Arg Ile Ala Ile Asn Phe Asp 
            100                 105                 110         


Gly Val Tyr Met Asn Ala Thr Val Trp Phe Asn Gly Val Lys Leu Gly 
        115                 120                 125             


Thr His Pro Tyr Gly Tyr Ser Pro Phe Ser Phe Asp Leu Thr Gly Asn 
    130                 135                 140                 


Ala Lys Phe Gly Gly Glu Asn Thr Ile Val Val Lys Val Glu Asn Arg 
145                 150                 155                 160 


Leu Pro Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val 
                165                 170                 175     


Thr Leu Thr Val Thr Asp Gly Val His Val Gly Asn Asn Gly Val Ala 
            180                 185                 190         


Ile Lys Thr Pro Ser Leu Ala Thr Gln Asn Gly Gly Asp Val Thr Met 
        195                 200                 205             


Asn Leu Thr Thr Lys Val Ala Asn Asp Thr Glu Ala Ala Ala Asn Ile 
    210                 215                 220                 


Thr Leu Lys Gln Thr Val Phe Pro Lys Gly Gly Lys Thr Asp Ala Ala 
225                 230                 235                 240 


Ile Gly Thr Val Thr Thr Ala Ser Lys Ser Ile Ala Ala Gly Ala Ser 
                245                 250                 255     


Ala Asp Val Thr Ser Thr Ile Thr Ala Ala Ser Pro Lys Leu Trp Ser 
            260                 265                 270         


Ile Lys Asn Pro Asn Leu Tyr Thr Val Arg Thr Glu Val Leu Asn Gly 
        275                 280                 285             


Gly Lys Val Leu Asp Thr Tyr Asp Thr Glu Tyr Gly Phe Arg Trp Thr 
    290                 295                 300                 


Gly Phe Asp Ala Thr Ser Gly Phe Ser Leu Asn Gly Glu Lys Val Lys 
305                 310                 315                 320 


Leu Lys Gly Val Ser Met His His Asp Gln Gly Ser Leu Gly Ala Val 
                325                 330                 335     


Ala Asn Arg Arg Ala Ile Glu Arg Gln Val Glu Ile Leu Gln Lys Met 
            340                 345                 350         


Gly Val Asn Ser Ile Arg Thr Thr His Asn Pro Ala Ala Lys Ala Leu 
        355                 360                 365             


Ile Asp Val Cys Asn Glu Lys Gly Val Leu Val Val Glu Glu Val Phe 
    370                 375                 380                 


Asp Met Trp Asn Arg Ser Lys Asn Gly Asn Thr Glu Asp Tyr Gly Lys 
385                 390                 395                 400 


Trp Phe Gly Gln Ala Ile Ala Gly Asp Asn Ala Val Leu Gly Gly Asp 
                405                 410                 415     


Lys Asp Glu Thr Trp Ala Lys Phe Asp Leu Thr Ser Thr Ile Asn Arg 
            420                 425                 430         


Asp Arg Asn Ala Pro Ser Val Ile Met Trp Ser Leu Gly Asn Glu Met 
        435                 440                 445             


Met Glu Gly Ile Ser Gly Ser Val Ser Gly Phe Pro Ala Thr Ser Ala 
    450                 455                 460                 


Lys Leu Val Ala Trp Thr Lys Ala Ala Asp Ser Thr Arg Pro Met Thr 
465                 470                 475                 480 


Tyr Gly Asp Asn Lys Ile Lys Ala Asn Trp Asn Glu Ser Asn Thr Met 
                485                 490                 495     


Gly Asp Asn Leu Thr Ala Asn Gly Gly Val Val Gly Thr Asn Tyr Ser 
            500                 505                 510         


Asp Gly Ala Asn Tyr Asp Lys Ile Arg Thr Thr His Pro Ser Trp Ala 
        515                 520                 525             


Ile Tyr Gly Ser Glu Thr Ala Ser Ala Ile Asn Ser Arg Gly Ile Tyr 
    530                 535                 540                 


Asn Arg Thr Thr Gly Gly Ala Gln Ser Ser Asp Lys Gln Leu Thr Ser 
545                 550                 555                 560 


Tyr Asp Asn Ser Ala Val Gly Trp Gly Ala Val Ala Ser Ser Ala Trp 
                565                 570                 575     


Tyr Asp Val Val Gln Arg Asp Phe Val Ala Gly Thr Tyr Val Trp Thr 
            580                 585                 590         


Gly Phe Asp Tyr Leu Gly Glu Pro Thr Pro Trp Asn Gly Thr Gly Ser 
        595                 600                 605             


Gly Ala Val Gly Ser Trp Pro Ser Pro Lys Asn Ser Tyr Phe Gly Ile 
    610                 615                 620                 


Val Asp Thr Ala Gly Phe Pro Lys Asp Thr Tyr Tyr Phe Tyr Gln Ser 
625                 630                 635                 640 


Gln Trp Asn Asp Asp Val His Thr Leu His Ile Leu Pro Ala Trp Asn 
                645                 650                 655     


Glu Asn Val Val Ala Lys Gly Ser Gly Asn Asn Val Pro Val Val Val 
            660                 665                 670         


Tyr Thr Asp Ala Ala Lys Val Lys Leu Tyr Phe Thr Pro Lys Gly Ser 
        675                 680                 685             


Thr Glu Lys Arg Leu Ile Gly Glu Lys Ser Phe Thr Lys Lys Thr Thr 
    690                 695                 700                 


Ala Ala Gly Tyr Thr Tyr Gln Val Tyr Glu Gly Ser Asp Lys Asp Ser 
705                 710                 715                 720 


Thr Ala His Lys Asn Met Tyr Leu Thr Trp Asn Val Pro Trp Ala Glu 
                725                 730                 735     


Gly Thr Ile Ser Ala Glu Ala Tyr Asp Glu Asn Asn Arg Leu Ile Pro 
            740                 745                 750         


Glu Gly Ser Thr Glu Gly Asn Ala Ser Val Thr Thr Thr Gly Lys Ala 
        755                 760                 765             


Ala Lys Leu Lys Ala Asp Ala Asp Arg Lys Thr Ile Thr Ala Asp Gly 
    770                 775                 780                 


Lys Asp Leu Ser Tyr Ile Glu Val Asp Val Thr Asp Ala Asn Gly His 
785                 790                 795                 800 


Ile Val Pro Asp Ala Ala Asn Arg Val Thr Phe Asp Val Lys Gly Ala 
                805                 810                 815     


Gly Lys Leu Val Gly Val Asp Asn Gly Ser Ser Pro Asp His Asp Ser 
            820                 825                 830         


Tyr Gln Ala Asp Asn Arg Lys Ala Phe Ser Gly Lys Val Leu Ala Ile 
        835                 840                 845             


Val Gln Ser Thr Lys Glu Ala Gly Glu Ile Thr Val Thr Ala Lys Ala 
    850                 855                 860                 


Asp Gly Leu Gln Ser Ser Thr Val Lys Ile Ala Thr Thr Ala Val Pro 
865                 870                 875                 880 


Gly Thr Ser Thr Glu Lys Thr Val Arg Ser Phe Tyr Tyr Ser Arg Asn 
                885                 890                 895     


Tyr Tyr Val Lys Thr Gly Asn Lys Pro Ile Leu Pro Ser Asp Val Glu 
            900                 905                 910         


Val Arg Tyr Ser Asp Gly Thr Ser Asp Arg Gln Asn Val Thr Trp Asp 
        915                 920                 925             


Ala Val Ser Asp Asp Gln Ile Ala Lys Ala Gly Ser Phe Ser Val Ala 
    930                 935                 940                 


Gly Thr Val Ala Gly Gln Lys Ile Ser Val Arg Val Thr Met Ile Asp 
945                 950                 955                 960 


Glu Ile Gly Ala Leu Leu Asn Tyr Ser Ala Ser Thr Pro Val Gly Thr 
                965                 970                 975     


Pro Ala Val Leu Pro Gly Ser Arg Pro Ala Val Leu Pro Asp Gly Thr 
            980                 985                 990         


Val Thr Ser Ala Asn Phe Ala Val  His Trp Thr Lys Pro  Ala Asp Thr 
        995                 1000                 1005             


Val Tyr  Asn Thr Ala Gly Thr  Val Lys Val Pro Gly  Thr Ala Thr 
    1010                 1015                 1020             


Val Phe  Gly Lys Glu Phe Lys  Val Thr Ala Thr Ile  Arg Val Gln 
    1025                 1030                 1035             


<210>  4
<211>  1142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated lactase fragment

<400>  4

Val Glu Asp Ala Thr Arg Ser Asp Ser Thr Thr Gln Met Ser Ser Thr 
1               5                   10                  15      


Pro Glu Val Val Tyr Ser Ser Ala Val Asp Ser Lys Gln Asn Arg Thr 
            20                  25                  30          


Ser Asp Phe Asp Ala Asn Trp Lys Phe Met Leu Ser Asp Ser Val Gln 
        35                  40                  45              


Ala Gln Asp Pro Ala Phe Asp Asp Ser Ala Trp Gln Gln Val Asp Leu 
    50                  55                  60                  


Pro His Asp Tyr Ser Ile Thr Gln Lys Tyr Ser Gln Ser Asn Glu Ala 
65                  70                  75                  80  


Glu Ser Ala Tyr Leu Pro Gly Gly Thr Gly Trp Tyr Arg Lys Ser Phe 
                85                  90                  95      


Thr Ile Asp Arg Asp Leu Ala Gly Lys Arg Ile Ala Ile Asn Phe Asp 
            100                 105                 110         


Gly Val Tyr Met Asn Ala Thr Val Trp Phe Asn Gly Val Lys Leu Gly 
        115                 120                 125             


Thr His Pro Tyr Gly Tyr Ser Pro Phe Ser Phe Asp Leu Thr Gly Asn 
    130                 135                 140                 


Ala Lys Phe Gly Gly Glu Asn Thr Ile Val Val Lys Val Glu Asn Arg 
145                 150                 155                 160 


Leu Pro Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val 
                165                 170                 175     


Thr Leu Thr Val Thr Asp Gly Val His Val Gly Asn Asn Gly Val Ala 
            180                 185                 190         


Ile Lys Thr Pro Ser Leu Ala Thr Gln Asn Gly Gly Asp Val Thr Met 
        195                 200                 205             


Asn Leu Thr Thr Lys Val Ala Asn Asp Thr Glu Ala Ala Ala Asn Ile 
    210                 215                 220                 


Thr Leu Lys Gln Thr Val Phe Pro Lys Gly Gly Lys Thr Asp Ala Ala 
225                 230                 235                 240 


Ile Gly Thr Val Thr Thr Ala Ser Lys Ser Ile Ala Ala Gly Ala Ser 
                245                 250                 255     


Ala Asp Val Thr Ser Thr Ile Thr Ala Ala Ser Pro Lys Leu Trp Ser 
            260                 265                 270         


Ile Lys Asn Pro Asn Leu Tyr Thr Val Arg Thr Glu Val Leu Asn Gly 
        275                 280                 285             


Gly Lys Val Leu Asp Thr Tyr Asp Thr Glu Tyr Gly Phe Arg Trp Thr 
    290                 295                 300                 


Gly Phe Asp Ala Thr Ser Gly Phe Ser Leu Asn Gly Glu Lys Val Lys 
305                 310                 315                 320 


Leu Lys Gly Val Ser Met His His Asp Gln Gly Ser Leu Gly Ala Val 
                325                 330                 335     


Ala Asn Arg Arg Ala Ile Glu Arg Gln Val Glu Ile Leu Gln Lys Met 
            340                 345                 350         


Gly Val Asn Ser Ile Arg Thr Thr His Asn Pro Ala Ala Lys Ala Leu 
        355                 360                 365             


Ile Asp Val Cys Asn Glu Lys Gly Val Leu Val Val Glu Glu Val Phe 
    370                 375                 380                 


Asp Met Trp Asn Arg Ser Lys Asn Gly Asn Thr Glu Asp Tyr Gly Lys 
385                 390                 395                 400 


Trp Phe Gly Gln Ala Ile Ala Gly Asp Asn Ala Val Leu Gly Gly Asp 
                405                 410                 415     


Lys Asp Glu Thr Trp Ala Lys Phe Asp Leu Thr Ser Thr Ile Asn Arg 
            420                 425                 430         


Asp Arg Asn Ala Pro Ser Val Ile Met Trp Ser Leu Gly Asn Glu Met 
        435                 440                 445             


Met Glu Gly Ile Ser Gly Ser Val Ser Gly Phe Pro Ala Thr Ser Ala 
    450                 455                 460                 


Lys Leu Val Ala Trp Thr Lys Ala Ala Asp Ser Thr Arg Pro Met Thr 
465                 470                 475                 480 


Tyr Gly Asp Asn Lys Ile Lys Ala Asn Trp Asn Glu Ser Asn Thr Met 
                485                 490                 495     


Gly Asp Asn Leu Thr Ala Asn Gly Gly Val Val Gly Thr Asn Tyr Ser 
            500                 505                 510         


Asp Gly Ala Asn Tyr Asp Lys Ile Arg Thr Thr His Pro Ser Trp Ala 
        515                 520                 525             


Ile Tyr Gly Ser Glu Thr Ala Ser Ala Ile Asn Ser Arg Gly Ile Tyr 
    530                 535                 540                 


Asn Arg Thr Thr Gly Gly Ala Gln Ser Ser Asp Lys Gln Leu Thr Ser 
545                 550                 555                 560 


Tyr Asp Asn Ser Ala Val Gly Trp Gly Ala Val Ala Ser Ser Ala Trp 
                565                 570                 575     


Tyr Asp Val Val Gln Arg Asp Phe Val Ala Gly Thr Tyr Val Trp Thr 
            580                 585                 590         


Gly Phe Asp Tyr Leu Gly Glu Pro Thr Pro Trp Asn Gly Thr Gly Ser 
        595                 600                 605             


Gly Ala Val Gly Ser Trp Pro Ser Pro Lys Asn Ser Tyr Phe Gly Ile 
    610                 615                 620                 


Val Asp Thr Ala Gly Phe Pro Lys Asp Thr Tyr Tyr Phe Tyr Gln Ser 
625                 630                 635                 640 


Gln Trp Asn Asp Asp Val His Thr Leu His Ile Leu Pro Ala Trp Asn 
                645                 650                 655     


Glu Asn Val Val Ala Lys Gly Ser Gly Asn Asn Val Pro Val Val Val 
            660                 665                 670         


Tyr Thr Asp Ala Ala Lys Val Lys Leu Tyr Phe Thr Pro Lys Gly Ser 
        675                 680                 685             


Thr Glu Lys Arg Leu Ile Gly Glu Lys Ser Phe Thr Lys Lys Thr Thr 
    690                 695                 700                 


Ala Ala Gly Tyr Thr Tyr Gln Val Tyr Glu Gly Ser Asp Lys Asp Ser 
705                 710                 715                 720 


Thr Ala His Lys Asn Met Tyr Leu Thr Trp Asn Val Pro Trp Ala Glu 
                725                 730                 735     


Gly Thr Ile Ser Ala Glu Ala Tyr Asp Glu Asn Asn Arg Leu Ile Pro 
            740                 745                 750         


Glu Gly Ser Thr Glu Gly Asn Ala Ser Val Thr Thr Thr Gly Lys Ala 
        755                 760                 765             


Ala Lys Leu Lys Ala Asp Ala Asp Arg Lys Thr Ile Thr Ala Asp Gly 
    770                 775                 780                 


Lys Asp Leu Ser Tyr Ile Glu Val Asp Val Thr Asp Ala Asn Gly His 
785                 790                 795                 800 


Ile Val Pro Asp Ala Ala Asn Arg Val Thr Phe Asp Val Lys Gly Ala 
                805                 810                 815     


Gly Lys Leu Val Gly Val Asp Asn Gly Ser Ser Pro Asp His Asp Ser 
            820                 825                 830         


Tyr Gln Ala Asp Asn Arg Lys Ala Phe Ser Gly Lys Val Leu Ala Ile 
        835                 840                 845             


Val Gln Ser Thr Lys Glu Ala Gly Glu Ile Thr Val Thr Ala Lys Ala 
    850                 855                 860                 


Asp Gly Leu Gln Ser Ser Thr Val Lys Ile Ala Thr Thr Ala Val Pro 
865                 870                 875                 880 


Gly Thr Ser Thr Glu Lys Thr Val Arg Ser Phe Tyr Tyr Ser Arg Asn 
                885                 890                 895     


Tyr Tyr Val Lys Thr Gly Asn Lys Pro Ile Leu Pro Ser Asp Val Glu 
            900                 905                 910         


Val Arg Tyr Ser Asp Gly Thr Ser Asp Arg Gln Asn Val Thr Trp Asp 
        915                 920                 925             


Ala Val Ser Asp Asp Gln Ile Ala Lys Ala Gly Ser Phe Ser Val Ala 
    930                 935                 940                 


Gly Thr Val Ala Gly Gln Lys Ile Ser Val Arg Val Thr Met Ile Asp 
945                 950                 955                 960 


Glu Ile Gly Ala Leu Leu Asn Tyr Ser Ala Ser Thr Pro Val Gly Thr 
                965                 970                 975     


Pro Ala Val Leu Pro Gly Ser Arg Pro Ala Val Leu Pro Asp Gly Thr 
            980                 985                 990         


Val Thr Ser Ala Asn Phe Ala Val  His Trp Thr Lys Pro  Ala Asp Thr 
        995                 1000                 1005             


Val Tyr  Asn Thr Ala Gly Thr  Val Lys Val Pro Gly  Thr Ala Thr 
    1010                 1015                 1020             


Val Phe  Gly Lys Glu Phe Lys  Val Thr Ala Thr Ile  Arg Val Gln 
    1025                 1030                 1035             


Arg Ser  Gln Val Thr Ile Gly  Ser Ser Val Ser Gly  Asn Ala Leu 
    1040                 1045                 1050             


Arg Leu  Thr Gln Asn Ile Pro  Ala Asp Lys Gln Ser  Asp Thr Leu 
    1055                 1060                 1065             


Asp Ala  Ile Lys Asp Gly Ser  Thr Thr Val Asp Ala  Asn Thr Gly 
    1070                 1075                 1080             


Gly Gly  Ala Asn Pro Ser Ala  Trp Thr Asn Trp Ala  Tyr Ser Lys 
    1085                 1090                 1095             


Ala Gly  His Asn Thr Ala Glu  Ile Thr Phe Glu Tyr  Ala Thr Glu 
    1100                 1105                 1110             


Gln Gln  Leu Gly Gln Ile Val  Met Tyr Phe Phe Arg  Asp Ser Asn 
    1115                 1120                 1125             


Ala Val  Arg Phe Pro Asp Ala  Gly Lys Thr Lys Ile  Gln Ile 
    1130                 1135                 1140         


<210>  5
<211>  1211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated lactase fragment

<400>  5

Val Glu Asp Ala Thr Arg Ser Asp Ser Thr Thr Gln Met Ser Ser Thr 
1               5                   10                  15      


Pro Glu Val Val Tyr Ser Ser Ala Val Asp Ser Lys Gln Asn Arg Thr 
            20                  25                  30          


Ser Asp Phe Asp Ala Asn Trp Lys Phe Met Leu Ser Asp Ser Val Gln 
        35                  40                  45              


Ala Gln Asp Pro Ala Phe Asp Asp Ser Ala Trp Gln Gln Val Asp Leu 
    50                  55                  60                  


Pro His Asp Tyr Ser Ile Thr Gln Lys Tyr Ser Gln Ser Asn Glu Ala 
65                  70                  75                  80  


Glu Ser Ala Tyr Leu Pro Gly Gly Thr Gly Trp Tyr Arg Lys Ser Phe 
                85                  90                  95      


Thr Ile Asp Arg Asp Leu Ala Gly Lys Arg Ile Ala Ile Asn Phe Asp 
            100                 105                 110         


Gly Val Tyr Met Asn Ala Thr Val Trp Phe Asn Gly Val Lys Leu Gly 
        115                 120                 125             


Thr His Pro Tyr Gly Tyr Ser Pro Phe Ser Phe Asp Leu Thr Gly Asn 
    130                 135                 140                 


Ala Lys Phe Gly Gly Glu Asn Thr Ile Val Val Lys Val Glu Asn Arg 
145                 150                 155                 160 


Leu Pro Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val 
                165                 170                 175     


Thr Leu Thr Val Thr Asp Gly Val His Val Gly Asn Asn Gly Val Ala 
            180                 185                 190         


Ile Lys Thr Pro Ser Leu Ala Thr Gln Asn Gly Gly Asp Val Thr Met 
        195                 200                 205             


Asn Leu Thr Thr Lys Val Ala Asn Asp Thr Glu Ala Ala Ala Asn Ile 
    210                 215                 220                 


Thr Leu Lys Gln Thr Val Phe Pro Lys Gly Gly Lys Thr Asp Ala Ala 
225                 230                 235                 240 


Ile Gly Thr Val Thr Thr Ala Ser Lys Ser Ile Ala Ala Gly Ala Ser 
                245                 250                 255     


Ala Asp Val Thr Ser Thr Ile Thr Ala Ala Ser Pro Lys Leu Trp Ser 
            260                 265                 270         


Ile Lys Asn Pro Asn Leu Tyr Thr Val Arg Thr Glu Val Leu Asn Gly 
        275                 280                 285             


Gly Lys Val Leu Asp Thr Tyr Asp Thr Glu Tyr Gly Phe Arg Trp Thr 
    290                 295                 300                 


Gly Phe Asp Ala Thr Ser Gly Phe Ser Leu Asn Gly Glu Lys Val Lys 
305                 310                 315                 320 


Leu Lys Gly Val Ser Met His His Asp Gln Gly Ser Leu Gly Ala Val 
                325                 330                 335     


Ala Asn Arg Arg Ala Ile Glu Arg Gln Val Glu Ile Leu Gln Lys Met 
            340                 345                 350         


Gly Val Asn Ser Ile Arg Thr Thr His Asn Pro Ala Ala Lys Ala Leu 
        355                 360                 365             


Ile Asp Val Cys Asn Glu Lys Gly Val Leu Val Val Glu Glu Val Phe 
    370                 375                 380                 


Asp Met Trp Asn Arg Ser Lys Asn Gly Asn Thr Glu Asp Tyr Gly Lys 
385                 390                 395                 400 


Trp Phe Gly Gln Ala Ile Ala Gly Asp Asn Ala Val Leu Gly Gly Asp 
                405                 410                 415     


Lys Asp Glu Thr Trp Ala Lys Phe Asp Leu Thr Ser Thr Ile Asn Arg 
            420                 425                 430         


Asp Arg Asn Ala Pro Ser Val Ile Met Trp Ser Leu Gly Asn Glu Met 
        435                 440                 445             


Met Glu Gly Ile Ser Gly Ser Val Ser Gly Phe Pro Ala Thr Ser Ala 
    450                 455                 460                 


Lys Leu Val Ala Trp Thr Lys Ala Ala Asp Ser Thr Arg Pro Met Thr 
465                 470                 475                 480 


Tyr Gly Asp Asn Lys Ile Lys Ala Asn Trp Asn Glu Ser Asn Thr Met 
                485                 490                 495     


Gly Asp Asn Leu Thr Ala Asn Gly Gly Val Val Gly Thr Asn Tyr Ser 
            500                 505                 510         


Asp Gly Ala Asn Tyr Asp Lys Ile Arg Thr Thr His Pro Ser Trp Ala 
        515                 520                 525             


Ile Tyr Gly Ser Glu Thr Ala Ser Ala Ile Asn Ser Arg Gly Ile Tyr 
    530                 535                 540                 


Asn Arg Thr Thr Gly Gly Ala Gln Ser Ser Asp Lys Gln Leu Thr Ser 
545                 550                 555                 560 


Tyr Asp Asn Ser Ala Val Gly Trp Gly Ala Val Ala Ser Ser Ala Trp 
                565                 570                 575     


Tyr Asp Val Val Gln Arg Asp Phe Val Ala Gly Thr Tyr Val Trp Thr 
            580                 585                 590         


Gly Phe Asp Tyr Leu Gly Glu Pro Thr Pro Trp Asn Gly Thr Gly Ser 
        595                 600                 605             


Gly Ala Val Gly Ser Trp Pro Ser Pro Lys Asn Ser Tyr Phe Gly Ile 
    610                 615                 620                 


Val Asp Thr Ala Gly Phe Pro Lys Asp Thr Tyr Tyr Phe Tyr Gln Ser 
625                 630                 635                 640 


Gln Trp Asn Asp Asp Val His Thr Leu His Ile Leu Pro Ala Trp Asn 
                645                 650                 655     


Glu Asn Val Val Ala Lys Gly Ser Gly Asn Asn Val Pro Val Val Val 
            660                 665                 670         


Tyr Thr Asp Ala Ala Lys Val Lys Leu Tyr Phe Thr Pro Lys Gly Ser 
        675                 680                 685             


Thr Glu Lys Arg Leu Ile Gly Glu Lys Ser Phe Thr Lys Lys Thr Thr 
    690                 695                 700                 


Ala Ala Gly Tyr Thr Tyr Gln Val Tyr Glu Gly Ser Asp Lys Asp Ser 
705                 710                 715                 720 


Thr Ala His Lys Asn Met Tyr Leu Thr Trp Asn Val Pro Trp Ala Glu 
                725                 730                 735     


Gly Thr Ile Ser Ala Glu Ala Tyr Asp Glu Asn Asn Arg Leu Ile Pro 
            740                 745                 750         


Glu Gly Ser Thr Glu Gly Asn Ala Ser Val Thr Thr Thr Gly Lys Ala 
        755                 760                 765             


Ala Lys Leu Lys Ala Asp Ala Asp Arg Lys Thr Ile Thr Ala Asp Gly 
    770                 775                 780                 


Lys Asp Leu Ser Tyr Ile Glu Val Asp Val Thr Asp Ala Asn Gly His 
785                 790                 795                 800 


Ile Val Pro Asp Ala Ala Asn Arg Val Thr Phe Asp Val Lys Gly Ala 
                805                 810                 815     


Gly Lys Leu Val Gly Val Asp Asn Gly Ser Ser Pro Asp His Asp Ser 
            820                 825                 830         


Tyr Gln Ala Asp Asn Arg Lys Ala Phe Ser Gly Lys Val Leu Ala Ile 
        835                 840                 845             


Val Gln Ser Thr Lys Glu Ala Gly Glu Ile Thr Val Thr Ala Lys Ala 
    850                 855                 860                 


Asp Gly Leu Gln Ser Ser Thr Val Lys Ile Ala Thr Thr Ala Val Pro 
865                 870                 875                 880 


Gly Thr Ser Thr Glu Lys Thr Val Arg Ser Phe Tyr Tyr Ser Arg Asn 
                885                 890                 895     


Tyr Tyr Val Lys Thr Gly Asn Lys Pro Ile Leu Pro Ser Asp Val Glu 
            900                 905                 910         


Val Arg Tyr Ser Asp Gly Thr Ser Asp Arg Gln Asn Val Thr Trp Asp 
        915                 920                 925             


Ala Val Ser Asp Asp Gln Ile Ala Lys Ala Gly Ser Phe Ser Val Ala 
    930                 935                 940                 


Gly Thr Val Ala Gly Gln Lys Ile Ser Val Arg Val Thr Met Ile Asp 
945                 950                 955                 960 


Glu Ile Gly Ala Leu Leu Asn Tyr Ser Ala Ser Thr Pro Val Gly Thr 
                965                 970                 975     


Pro Ala Val Leu Pro Gly Ser Arg Pro Ala Val Leu Pro Asp Gly Thr 
            980                 985                 990         


Val Thr Ser Ala Asn Phe Ala Val  His Trp Thr Lys Pro  Ala Asp Thr 
        995                 1000                 1005             


Val Tyr  Asn Thr Ala Gly Thr  Val Lys Val Pro Gly  Thr Ala Thr 
    1010                 1015                 1020             


Val Phe  Gly Lys Glu Phe Lys  Val Thr Ala Thr Ile  Arg Val Gln 
    1025                 1030                 1035             


Arg Ser  Gln Val Thr Ile Gly  Ser Ser Val Ser Gly  Asn Ala Leu 
    1040                 1045                 1050             


Arg Leu  Thr Gln Asn Ile Pro  Ala Asp Lys Gln Ser  Asp Thr Leu 
    1055                 1060                 1065             


Asp Ala  Ile Lys Asp Gly Ser  Thr Thr Val Asp Ala  Asn Thr Gly 
    1070                 1075                 1080             


Gly Gly  Ala Asn Pro Ser Ala  Trp Thr Asn Trp Ala  Tyr Ser Lys 
    1085                 1090                 1095             


Ala Gly  His Asn Thr Ala Glu  Ile Thr Phe Glu Tyr  Ala Thr Glu 
    1100                 1105                 1110             


Gln Gln  Leu Gly Gln Ile Val  Met Tyr Phe Phe Arg  Asp Ser Asn 
    1115                 1120                 1125             


Ala Val  Arg Phe Pro Asp Ala  Gly Lys Thr Lys Ile  Gln Ile Ser 
    1130                 1135                 1140             


Ala Asp  Gly Lys Asn Trp Thr  Asp Leu Ala Ala Thr  Glu Thr Ile 
    1145                 1150                 1155             


Ala Ala  Gln Glu Ser Ser Asp  Arg Val Lys Pro Tyr  Thr Tyr Asp 
    1160                 1165                 1170             


Phe Ala  Pro Val Gly Ala Thr  Phe Val Lys Val Thr  Val Thr Asn 
    1175                 1180                 1185             


Ala Asp  Thr Thr Thr Pro Ser  Gly Val Val Cys Ala  Gly Leu Thr 
    1190                 1195                 1200             


Glu Ile  Glu Leu Lys Thr Ala  Thr 
    1205                 1210     


<210>  6
<211>  1296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated lactase fragment

<400>  6

Val Glu Asp Ala Thr Arg Ser Asp Ser Thr Thr Gln Met Ser Ser Thr 
1               5                   10                  15      


Pro Glu Val Val Tyr Ser Ser Ala Val Asp Ser Lys Gln Asn Arg Thr 
            20                  25                  30          


Ser Asp Phe Asp Ala Asn Trp Lys Phe Met Leu Ser Asp Ser Val Gln 
        35                  40                  45              


Ala Gln Asp Pro Ala Phe Asp Asp Ser Ala Trp Gln Gln Val Asp Leu 
    50                  55                  60                  


Pro His Asp Tyr Ser Ile Thr Gln Lys Tyr Ser Gln Ser Asn Glu Ala 
65                  70                  75                  80  


Glu Ser Ala Tyr Leu Pro Gly Gly Thr Gly Trp Tyr Arg Lys Ser Phe 
                85                  90                  95      


Thr Ile Asp Arg Asp Leu Ala Gly Lys Arg Ile Ala Ile Asn Phe Asp 
            100                 105                 110         


Gly Val Tyr Met Asn Ala Thr Val Trp Phe Asn Gly Val Lys Leu Gly 
        115                 120                 125             


Thr His Pro Tyr Gly Tyr Ser Pro Phe Ser Phe Asp Leu Thr Gly Asn 
    130                 135                 140                 


Ala Lys Phe Gly Gly Glu Asn Thr Ile Val Val Lys Val Glu Asn Arg 
145                 150                 155                 160 


Leu Pro Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val 
                165                 170                 175     


Thr Leu Thr Val Thr Asp Gly Val His Val Gly Asn Asn Gly Val Ala 
            180                 185                 190         


Ile Lys Thr Pro Ser Leu Ala Thr Gln Asn Gly Gly Asp Val Thr Met 
        195                 200                 205             


Asn Leu Thr Thr Lys Val Ala Asn Asp Thr Glu Ala Ala Ala Asn Ile 
    210                 215                 220                 


Thr Leu Lys Gln Thr Val Phe Pro Lys Gly Gly Lys Thr Asp Ala Ala 
225                 230                 235                 240 


Ile Gly Thr Val Thr Thr Ala Ser Lys Ser Ile Ala Ala Gly Ala Ser 
                245                 250                 255     


Ala Asp Val Thr Ser Thr Ile Thr Ala Ala Ser Pro Lys Leu Trp Ser 
            260                 265                 270         


Ile Lys Asn Pro Asn Leu Tyr Thr Val Arg Thr Glu Val Leu Asn Gly 
        275                 280                 285             


Gly Lys Val Leu Asp Thr Tyr Asp Thr Glu Tyr Gly Phe Arg Trp Thr 
    290                 295                 300                 


Gly Phe Asp Ala Thr Ser Gly Phe Ser Leu Asn Gly Glu Lys Val Lys 
305                 310                 315                 320 


Leu Lys Gly Val Ser Met His His Asp Gln Gly Ser Leu Gly Ala Val 
                325                 330                 335     


Ala Asn Arg Arg Ala Ile Glu Arg Gln Val Glu Ile Leu Gln Lys Met 
            340                 345                 350         


Gly Val Asn Ser Ile Arg Thr Thr His Asn Pro Ala Ala Lys Ala Leu 
        355                 360                 365             


Ile Asp Val Cys Asn Glu Lys Gly Val Leu Val Val Glu Glu Val Phe 
    370                 375                 380                 


Asp Met Trp Asn Arg Ser Lys Asn Gly Asn Thr Glu Asp Tyr Gly Lys 
385                 390                 395                 400 


Trp Phe Gly Gln Ala Ile Ala Gly Asp Asn Ala Val Leu Gly Gly Asp 
                405                 410                 415     


Lys Asp Glu Thr Trp Ala Lys Phe Asp Leu Thr Ser Thr Ile Asn Arg 
            420                 425                 430         


Asp Arg Asn Ala Pro Ser Val Ile Met Trp Ser Leu Gly Asn Glu Met 
        435                 440                 445             


Met Glu Gly Ile Ser Gly Ser Val Ser Gly Phe Pro Ala Thr Ser Ala 
    450                 455                 460                 


Lys Leu Val Ala Trp Thr Lys Ala Ala Asp Ser Thr Arg Pro Met Thr 
465                 470                 475                 480 


Tyr Gly Asp Asn Lys Ile Lys Ala Asn Trp Asn Glu Ser Asn Thr Met 
                485                 490                 495     


Gly Asp Asn Leu Thr Ala Asn Gly Gly Val Val Gly Thr Asn Tyr Ser 
            500                 505                 510         


Asp Gly Ala Asn Tyr Asp Lys Ile Arg Thr Thr His Pro Ser Trp Ala 
        515                 520                 525             


Ile Tyr Gly Ser Glu Thr Ala Ser Ala Ile Asn Ser Arg Gly Ile Tyr 
    530                 535                 540                 


Asn Arg Thr Thr Gly Gly Ala Gln Ser Ser Asp Lys Gln Leu Thr Ser 
545                 550                 555                 560 


Tyr Asp Asn Ser Ala Val Gly Trp Gly Ala Val Ala Ser Ser Ala Trp 
                565                 570                 575     


Tyr Asp Val Val Gln Arg Asp Phe Val Ala Gly Thr Tyr Val Trp Thr 
            580                 585                 590         


Gly Phe Asp Tyr Leu Gly Glu Pro Thr Pro Trp Asn Gly Thr Gly Ser 
        595                 600                 605             


Gly Ala Val Gly Ser Trp Pro Ser Pro Lys Asn Ser Tyr Phe Gly Ile 
    610                 615                 620                 


Val Asp Thr Ala Gly Phe Pro Lys Asp Thr Tyr Tyr Phe Tyr Gln Ser 
625                 630                 635                 640 


Gln Trp Asn Asp Asp Val His Thr Leu His Ile Leu Pro Ala Trp Asn 
                645                 650                 655     


Glu Asn Val Val Ala Lys Gly Ser Gly Asn Asn Val Pro Val Val Val 
            660                 665                 670         


Tyr Thr Asp Ala Ala Lys Val Lys Leu Tyr Phe Thr Pro Lys Gly Ser 
        675                 680                 685             


Thr Glu Lys Arg Leu Ile Gly Glu Lys Ser Phe Thr Lys Lys Thr Thr 
    690                 695                 700                 


Ala Ala Gly Tyr Thr Tyr Gln Val Tyr Glu Gly Ser Asp Lys Asp Ser 
705                 710                 715                 720 


Thr Ala His Lys Asn Met Tyr Leu Thr Trp Asn Val Pro Trp Ala Glu 
                725                 730                 735     


Gly Thr Ile Ser Ala Glu Ala Tyr Asp Glu Asn Asn Arg Leu Ile Pro 
            740                 745                 750         


Glu Gly Ser Thr Glu Gly Asn Ala Ser Val Thr Thr Thr Gly Lys Ala 
        755                 760                 765             


Ala Lys Leu Lys Ala Asp Ala Asp Arg Lys Thr Ile Thr Ala Asp Gly 
    770                 775                 780                 


Lys Asp Leu Ser Tyr Ile Glu Val Asp Val Thr Asp Ala Asn Gly His 
785                 790                 795                 800 


Ile Val Pro Asp Ala Ala Asn Arg Val Thr Phe Asp Val Lys Gly Ala 
                805                 810                 815     


Gly Lys Leu Val Gly Val Asp Asn Gly Ser Ser Pro Asp His Asp Ser 
            820                 825                 830         


Tyr Gln Ala Asp Asn Arg Lys Ala Phe Ser Gly Lys Val Leu Ala Ile 
        835                 840                 845             


Val Gln Ser Thr Lys Glu Ala Gly Glu Ile Thr Val Thr Ala Lys Ala 
    850                 855                 860                 


Asp Gly Leu Gln Ser Ser Thr Val Lys Ile Ala Thr Thr Ala Val Pro 
865                 870                 875                 880 


Gly Thr Ser Thr Glu Lys Thr Val Arg Ser Phe Tyr Tyr Ser Arg Asn 
                885                 890                 895     


Tyr Tyr Val Lys Thr Gly Asn Lys Pro Ile Leu Pro Ser Asp Val Glu 
            900                 905                 910         


Val Arg Tyr Ser Asp Gly Thr Ser Asp Arg Gln Asn Val Thr Trp Asp 
        915                 920                 925             


Ala Val Ser Asp Asp Gln Ile Ala Lys Ala Gly Ser Phe Ser Val Ala 
    930                 935                 940                 


Gly Thr Val Ala Gly Gln Lys Ile Ser Val Arg Val Thr Met Ile Asp 
945                 950                 955                 960 


Glu Ile Gly Ala Leu Leu Asn Tyr Ser Ala Ser Thr Pro Val Gly Thr 
                965                 970                 975     


Pro Ala Val Leu Pro Gly Ser Arg Pro Ala Val Leu Pro Asp Gly Thr 
            980                 985                 990         


Val Thr Ser Ala Asn Phe Ala Val  His Trp Thr Lys Pro  Ala Asp Thr 
        995                 1000                 1005             


Val Tyr  Asn Thr Ala Gly Thr  Val Lys Val Pro Gly  Thr Ala Thr 
    1010                 1015                 1020             


Val Phe  Gly Lys Glu Phe Lys  Val Thr Ala Thr Ile  Arg Val Gln 
    1025                 1030                 1035             


Arg Ser  Gln Val Thr Ile Gly  Ser Ser Val Ser Gly  Asn Ala Leu 
    1040                 1045                 1050             


Arg Leu  Thr Gln Asn Ile Pro  Ala Asp Lys Gln Ser  Asp Thr Leu 
    1055                 1060                 1065             


Asp Ala  Ile Lys Asp Gly Ser  Thr Thr Val Asp Ala  Asn Thr Gly 
    1070                 1075                 1080             


Gly Gly  Ala Asn Pro Ser Ala  Trp Thr Asn Trp Ala  Tyr Ser Lys 
    1085                 1090                 1095             


Ala Gly  His Asn Thr Ala Glu  Ile Thr Phe Glu Tyr  Ala Thr Glu 
    1100                 1105                 1110             


Gln Gln  Leu Gly Gln Ile Val  Met Tyr Phe Phe Arg  Asp Ser Asn 
    1115                 1120                 1125             


Ala Val  Arg Phe Pro Asp Ala  Gly Lys Thr Lys Ile  Gln Ile Ser 
    1130                 1135                 1140             


Ala Asp  Gly Lys Asn Trp Thr  Asp Leu Ala Ala Thr  Glu Thr Ile 
    1145                 1150                 1155             


Ala Ala  Gln Glu Ser Ser Asp  Arg Val Lys Pro Tyr  Thr Tyr Asp 
    1160                 1165                 1170             


Phe Ala  Pro Val Gly Ala Thr  Phe Val Lys Val Thr  Val Thr Asn 
    1175                 1180                 1185             


Ala Asp  Thr Thr Thr Pro Ser  Gly Val Val Cys Ala  Gly Leu Thr 
    1190                 1195                 1200             


Glu Ile  Glu Leu Lys Thr Ala  Thr Ser Lys Phe Val  Thr Asn Thr 
    1205                 1210                 1215             


Ser Ala  Ala Leu Ser Ser Leu  Thr Val Asn Gly Thr  Lys Val Ser 
    1220                 1225                 1230             


Asp Ser  Val Leu Ala Ala Gly  Ser Tyr Asn Thr Pro  Ala Ile Ile 
    1235                 1240                 1245             


Ala Asp  Val Lys Ala Glu Gly  Glu Gly Asn Ala Ser  Val Thr Val 
    1250                 1255                 1260             


Leu Pro  Ala His Asp Asn Val  Ile Arg Val Ile Thr  Glu Ser Glu 
    1265                 1270                 1275             


Asp His  Val Thr Arg Lys Thr  Phe Thr Ile Asn Leu  Gly Thr Glu 
    1280                 1285                 1290             


Gln Glu  Phe 
    1295     


<210>  7
<211>  453
<212>  PRT
<213>  Bifidobacterium bifidum

<400>  7

Gln Asn Arg Thr Ser Asp Phe Asp Ala Asn Trp Lys Phe Met Leu Ser 
1               5                   10                  15      


Asp Ser Val Gln Ala Gln Asp Pro Ala Phe Asp Asp Ser Ala Trp Gln 
            20                  25                  30          


Gln Val Asp Leu Pro His Asp Tyr Ser Ile Thr Gln Lys Tyr Ser Gln 
        35                  40                  45              


Ser Asn Glu Ala Glu Ser Ala Tyr Leu Pro Gly Gly Thr Gly Trp Tyr 
    50                  55                  60                  


Arg Lys Ser Phe Thr Ile Asp Arg Asp Leu Ala Gly Lys Arg Ile Ala 
65                  70                  75                  80  


Ile Asn Phe Asp Gly Val Tyr Met Asn Ala Thr Val Trp Phe Asn Gly 
                85                  90                  95      


Val Lys Leu Gly Thr His Pro Tyr Gly Tyr Ser Pro Phe Ser Phe Asp 
            100                 105                 110         


Leu Thr Gly Asn Ala Lys Phe Gly Gly Glu Asn Thr Ile Val Val Lys 
        115                 120                 125             


Val Glu Asn Arg Leu Pro Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile 
    130                 135                 140                 


Tyr Arg Asp Val Thr Leu Thr Val Thr Asp Gly Val His Val Gly Asn 
145                 150                 155                 160 


Asn Gly Val Ala Ile Lys Thr Pro Ser Leu Ala Thr Gln Asn Gly Gly 
                165                 170                 175     


Asp Val Thr Met Asn Leu Thr Thr Lys Val Ala Asn Asp Thr Glu Ala 
            180                 185                 190         


Ala Ala Asn Ile Thr Leu Lys Gln Thr Val Phe Pro Lys Gly Gly Lys 
        195                 200                 205             


Thr Asp Ala Ala Ile Gly Thr Val Thr Thr Ala Ser Lys Ser Ile Ala 
    210                 215                 220                 


Ala Gly Ala Ser Ala Asp Val Thr Ser Thr Ile Thr Ala Ala Ser Pro 
225                 230                 235                 240 


Lys Leu Trp Ser Ile Lys Asn Pro Asn Leu Tyr Thr Val Arg Thr Glu 
                245                 250                 255     


Val Leu Asn Gly Gly Lys Val Leu Asp Thr Tyr Asp Thr Glu Tyr Gly 
            260                 265                 270         


Phe Arg Trp Thr Gly Phe Asp Ala Thr Ser Gly Phe Ser Leu Asn Gly 
        275                 280                 285             


Glu Lys Val Lys Leu Lys Gly Val Ser Met His His Asp Gln Gly Ser 
    290                 295                 300                 


Leu Gly Ala Val Ala Asn Arg Arg Ala Ile Glu Arg Gln Val Glu Ile 
305                 310                 315                 320 


Leu Gln Lys Met Gly Val Asn Ser Ile Arg Thr Thr His Asn Pro Ala 
                325                 330                 335     


Ala Lys Ala Leu Ile Asp Val Cys Asn Glu Lys Gly Val Leu Val Val 
            340                 345                 350         


Glu Glu Val Phe Asp Met Trp Asn Arg Ser Lys Asn Gly Asn Thr Glu 
        355                 360                 365             


Asp Tyr Gly Lys Trp Phe Gly Gln Ala Ile Ala Gly Asp Asn Ala Val 
    370                 375                 380                 


Leu Gly Gly Asp Lys Asp Glu Thr Trp Ala Lys Phe Asp Leu Thr Ser 
385                 390                 395                 400 


Thr Ile Asn Arg Asp Arg Asn Ala Pro Ser Val Ile Met Trp Ser Leu 
                405                 410                 415     


Gly Asn Glu Met Met Glu Gly Ile Ser Gly Ser Val Ser Gly Phe Pro 
            420                 425                 430         


Ala Thr Ser Ala Lys Leu Val Ala Trp Thr Lys Ala Ala Asp Ser Thr 
        435                 440                 445             


Arg Pro Met Thr Tyr 
    450             


<210>  8
<211>  5160
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding an extracellular lactase

<400>  8
gcagttgaag atgcaacaag aagcgatagc acaacacaaa tgtcatcaac accggaagtt       60

gtttattcat cagcggtcga tagcaaacaa aatcgcacaa gcgattttga tgcgaactgg      120

aaatttatgc tgtcagatag cgttcaagca caagatccgg catttgatga ttcagcatgg      180

caacaagttg atctgccgca tgattatagc atcacacaga aatatagcca aagcaatgaa      240

gcagaatcag catatcttcc gggaggcaca ggctggtata gaaaaagctt tacaattgat      300

agagatctgg caggcaaacg cattgcgatt aattttgatg gcgtctatat gaatgcaaca      360

gtctggttta atggcgttaa actgggcaca catccgtatg gctattcacc gttttcattt      420

gatctgacag gcaatgcaaa atttggcgga gaaaacacaa ttgtcgtcaa agttgaaaat      480

agactgccgt catcaagatg gtattcaggc agcggcattt atagagatgt tacactgaca      540

gttacagatg gcgttcatgt tggcaataat ggcgtcgcaa ttaaaacacc gtcactggca      600

acacaaaatg gcggagatgt cacaatgaac ctgacaacaa aagtcgcgaa tgatacagaa      660

gcagcagcga acattacact gaaacagaca gtttttccga aaggcggaaa aacggatgca      720

gcaattggca cagttacaac agcatcaaaa tcaattgcag caggcgcatc agcagatgtt      780

acaagcacaa ttacagcagc aagcccgaaa ctgtggtcaa ttaaaaaccc gaacctgtat      840

acagttagaa cagaagttct gaacggaggc aaagttctgg atacatatga tacagaatat      900

ggctttcgct ggacaggctt tgatgcaaca tcaggctttt cactgaatgg cgaaaaagtc      960

aaactgaaag gcgttagcat gcatcatgat caaggctcac ttggcgcagt tgcaaataga     1020

cgcgcaattg aaagacaagt cgaaatcctg caaaaaatgg gcgtcaatag cattcgcaca     1080

acacataatc cggcagcaaa agcactgatt gatgtctgca atgaaaaagg cgttctggtt     1140

gtcgaagaag tctttgatat gtggaaccgc agcaaaaatg gcaacacgga agattatggc     1200

aaatggtttg gccaagcaat tgcaggcgat aatgcagttc tgggaggcga taaagatgaa     1260

acatgggcga aatttgatct tacatcaaca attaaccgcg atagaaatgc accgtcagtt     1320

attatgtggt cactgggcaa tgaaatgatg gaaggcattt caggctcagt ttcaggcttt     1380

ccggcaacat cagcaaaact ggttgcatgg acaaaagcag cagattcaac aagaccgatg     1440

acatatggcg ataacaaaat taaagcgaac tggaacgaat caaatacaat gggcgataat     1500

ctgacagcaa atggcggagt tgttggcaca aattattcag atggcgcaaa ctatgataaa     1560

attcgtacaa cacatccgtc atgggcaatt tatggctcag aaacagcatc agcgattaat     1620

agccgtggca tttataatag aacaacaggc ggagcacaat catcagataa acagctgaca     1680

agctatgata attcagcagt tggctgggga gcagttgcat catcagcatg gtatgatgtt     1740

gttcagagag attttgtcgc aggcacatat gtttggacag gatttgatta tctgggcgaa     1800

ccgacaccgt ggaatggcac aggctcaggc gcagttggct catggccgtc accgaaaaat     1860

agctattttg gcatcgttga tacagcaggc tttccgaaag atacatatta tttttatcag     1920

agccagtgga atgatgatgt tcatacactg catattcttc cggcatggaa tgaaaatgtt     1980

gttgcaaaag gctcaggcaa taatgttccg gttgtcgttt atacagatgc agcgaaagtg     2040

aaactgtatt ttacaccgaa aggctcaaca gaaaaaagac tgatcggcga aaaatcattt     2100

acaaaaaaaa caacagcggc aggctataca tatcaagtct atgaaggcag cgataaagat     2160

tcaacagcgc ataaaaacat gtatctgaca tggaatgttc cgtgggcaga aggcacaatt     2220

tcagcggaag cgtatgatga aaataatcgc ctgattccgg aaggcagcac agaaggcaac     2280

gcatcagtta caacaacagg caaagcagca aaactgaaag cagatgcgga tcgcaaaaca     2340

attacagcgg atggcaaaga tctgtcatat attgaagtcg atgtcacaga tgcaaatggc     2400

catattgttc cggatgcagc aaatagagtc acatttgatg ttaaaggcgc aggcaaactg     2460

gttggcgttg ataatggctc atcaccggat catgattcat atcaagcgga taaccgcaaa     2520

gcattttcag gcaaagtcct ggcaattgtt cagtcaacaa aagaagcagg cgaaattaca     2580

gttacagcaa aagcagatgg cctgcaatca agcacagtta aaattgcaac aacagcagtt     2640

ccgggaacaa gcacagaaaa aacagtccgc agcttttatt acagccgcaa ctattatgtc     2700

aaaacaggca acaaaccgat tctgccgtca gatgttgaag ttcgctattc agatggaaca     2760

agcgatagac aaaacgttac atgggatgca gtttcagatg atcaaattgc aaaagcaggc     2820

tcattttcag ttgcaggcac agttgcaggc caaaaaatta gcgttcgcgt cacaatgatt     2880

gatgaaattg gcgcactgct gaattattca gcaagcacac cggttggcac accggcagtt     2940

cttccgggat caagaccggc agtcctgccg gatggcacag tcacatcagc aaattttgca     3000

gtccattgga caaaaccggc agatacagtc tataatacag caggcacagt caaagtaccg     3060

ggaacagcaa cagtttttgg caaagaattt aaagtcacag cgacaattag agttcaaaga     3120

agccaagtta caattggctc atcagtttca ggaaatgcac tgagactgac acaaaatatt     3180

ccggcagata aacaatcaga tacactggat gcgattaaag atggctcaac aacagttgat     3240

gcaaatacag gcggaggcgc aaatccgtca gcatggacaa attgggcata ttcaaaagca     3300

ggccataaca cagcggaaat tacatttgaa tatgcgacag aacaacaact gggccagatc     3360

gtcatgtatt tttttcgcga tagcaatgca gttagatttc cggatgctgg caaaacaaaa     3420

attcagatca gcgcagatgg caaaaattgg acagatctgg cagcaacaga aacaattgca     3480

gcgcaagaat caagcgatag agtcaaaccg tatacatatg attttgcacc ggttggcgca     3540

acatttgtta aagtgacagt cacaaacgca gatacaacaa caccgtcagg cgttgtttgc     3600

gcaggcctga cagaaattga actgaaaaca gcgacaagca aatttgtcac aaatacatca     3660

gcagcactgt catcacttac agtcaatggc acaaaagttt cagattcagt tctggcagca     3720

ggctcatata acacaccggc aattatcgca gatgttaaag cggaaggcga aggcaatgca     3780

agcgttacag tccttccggc acatgataat gttattcgcg tcattacaga aagcgaagat     3840

catgtcacac gcaaaacatt tacaatcaac ctgggcacag aacaagaatt tccggctgat     3900

tcagatgaaa gagattatcc ggcagcagat atgacagtca cagttggctc agaacaaaca     3960

tcaggcacag caacagaagg accgaaaaaa tttgcagtcg atggcaacac atcaacatat     4020

tggcatagca attggacacc gacaacagtt aatgatctgt ggatcgcgtt tgaactgcaa     4080

aaaccgacaa aactggatgc actgagatat cttccgcgtc cggcaggctc aaaaaatggc     4140

agcgtcacag aatataaagt tcaggtgtca gatgatggaa caaactggac agatgcaggc     4200

tcaggcacat ggacaacgga ttatggctgg aaactggcgg aatttaatca accggtcaca     4260

acaaaacatg ttagactgaa agcggttcat acatatgcag atagcggcaa cgataaattt     4320

atgagcgcaa gcgaaattag actgagaaaa gcggtcgata caacggatat ttcaggcgca     4380

acagttacag ttccggcaaa actgacagtt gatagagttg atgcagatca tccggcaaca     4440

tttgcaacaa aagatgtcac agttacactg ggagatgcaa cactgagata tggcgttgat     4500

tatctgctgg attatgcagg caatacagca gttggcaaag caacagtgac agttagaggc     4560

attgataaat attcaggcac agtcgcgaaa acatttacaa ttgaactgaa aaatgcaccg     4620

gcaccggaac cgacactgac atcagttagc gtcaaaacaa aaccgagcaa actgacatat     4680

gttgtcggag atgcatttga tccggcaggc ctggttctgc aacatgatag acaagcagat     4740

agacctccgc aaccgctggt tggcgaacaa gcggatgaac gcggactgac atgcggcaca     4800

agatgcgata gagttgaaca actgcgcaaa catgaaaata gagaagcgca tagaacaggc     4860

ctggatcatc tggaatttgt tggcgcagca gatggcgcag ttggagaaca agcaacattt     4920

aaagtccatg tccatgcaga tcagggagat ggcagacatg atgatgcaga tgaacgcgat     4980

attgatccgc atgttccggt cgatcatgca gttggcgaac tggcaagagc agcatgccat     5040

catgttattg gcctgagagt cgatacacat agacttaaag caagcggctt tcaaattccg     5100

gctgatgata tggcagaaat cgatcgcatt acaggctttc atcgttttga acgccatgtc     5160


<210>  9
<211>  2661
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding BIF_917

<400>  9
gttgaagatg caacaagaag cgatagcaca acacaaatgt catcaacacc ggaagttgtt       60

tattcatcag cggtcgatag caaacaaaat cgcacaagcg attttgatgc gaactggaaa      120

tttatgctgt cagatagcgt tcaagcacaa gatccggcat ttgatgattc agcatggcaa      180

caagttgatc tgccgcatga ttatagcatc acacagaaat atagccaaag caatgaagca      240

gaatcagcat atcttccggg aggcacaggc tggtatagaa aaagctttac aattgataga      300

gatctggcag gcaaacgcat tgcgattaat tttgatggcg tctatatgaa tgcaacagtc      360

tggtttaatg gcgttaaact gggcacacat ccgtatggct attcaccgtt ttcatttgat      420

ctgacaggca atgcaaaatt tggcggagaa aacacaattg tcgtcaaagt tgaaaataga      480

ctgccgtcat caagatggta ttcaggcagc ggcatttata gagatgttac actgacagtt      540

acagatggcg ttcatgttgg caataatggc gtcgcaatta aaacaccgtc actggcaaca      600

caaaatggcg gagatgtcac aatgaacctg acaacaaaag tcgcgaatga tacagaagca      660

gcagcgaaca ttacactgaa acagacagtt tttccgaaag gcggaaaaac ggatgcagca      720

attggcacag ttacaacagc atcaaaatca attgcagcag gcgcatcagc agatgttaca      780

agcacaatta cagcagcaag cccgaaactg tggtcaatta aaaacccgaa cctgtataca      840

gttagaacag aagttctgaa cggaggcaaa gttctggata catatgatac agaatatggc      900

tttcgctgga caggctttga tgcaacatca ggcttttcac tgaatggcga aaaagtcaaa      960

ctgaaaggcg ttagcatgca tcatgatcaa ggctcacttg gcgcagttgc aaatagacgc     1020

gcaattgaaa gacaagtcga aatcctgcaa aaaatgggcg tcaatagcat tcgcacaaca     1080

cataatccgg cagcaaaagc actgattgat gtctgcaatg aaaaaggcgt tctggttgtc     1140

gaagaagtct ttgatatgtg gaaccgcagc aaaaatggca acacggaaga ttatggcaaa     1200

tggtttggcc aagcaattgc aggcgataat gcagttctgg gaggcgataa agatgaaaca     1260

tgggcgaaat ttgatcttac atcaacaatt aaccgcgata gaaatgcacc gtcagttatt     1320

atgtggtcac tgggcaatga aatgatggaa ggcatttcag gctcagtttc aggctttccg     1380

gcaacatcag caaaactggt tgcatggaca aaagcagcag attcaacaag accgatgaca     1440

tatggcgata acaaaattaa agcgaactgg aacgaatcaa atacaatggg cgataatctg     1500

acagcaaatg gcggagttgt tggcacaaat tattcagatg gcgcaaacta tgataaaatt     1560

cgtacaacac atccgtcatg ggcaatttat ggctcagaaa cagcatcagc gattaatagc     1620

cgtggcattt ataatagaac aacaggcgga gcacaatcat cagataaaca gctgacaagc     1680

tatgataatt cagcagttgg ctggggagca gttgcatcat cagcatggta tgatgttgtt     1740

cagagagatt ttgtcgcagg cacatatgtt tggacaggat ttgattatct gggcgaaccg     1800

acaccgtgga atggcacagg ctcaggcgca gttggctcat ggccgtcacc gaaaaatagc     1860

tattttggca tcgttgatac agcaggcttt ccgaaagata catattattt ttatcagagc     1920

cagtggaatg atgatgttca tacactgcat attcttccgg catggaatga aaatgttgtt     1980

gcaaaaggct caggcaataa tgttccggtt gtcgtttata cagatgcagc gaaagtgaaa     2040

ctgtatttta caccgaaagg ctcaacagaa aaaagactga tcggcgaaaa atcatttaca     2100

aaaaaaacaa cagcggcagg ctatacatat caagtctatg aaggcagcga taaagattca     2160

acagcgcata aaaacatgta tctgacatgg aatgttccgt gggcagaagg cacaatttca     2220

gcggaagcgt atgatgaaaa taatcgcctg attccggaag gcagcacaga aggcaacgca     2280

tcagttacaa caacaggcaa agcagcaaaa ctgaaagcag atgcggatcg caaaacaatt     2340

acagcggatg gcaaagatct gtcatatatt gaagtcgatg tcacagatgc aaatggccat     2400

attgttccgg atgcagcaaa tagagtcaca tttgatgtta aaggcgcagg caaactggtt     2460

ggcgttgata atggctcatc accggatcat gattcatatc aagcggataa ccgcaaagca     2520

ttttcaggca aagtcctggc aattgttcag tcaacaaaag aagcaggcga aattacagtt     2580

acagcaaaag cagatggcct gcaatcaagc acagttaaaa ttgcaacaac agcagttccg     2640

ggaacaagca cagaaaaaac a                                               2661


<210>  10
<211>  2895
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding BIF_995

<400>  10
gttgaagatg caacaagaag cgatagcaca acacaaatgt catcaacacc ggaagttgtt       60

tattcatcag cggtcgatag caaacaaaat cgcacaagcg attttgatgc gaactggaaa      120

tttatgctgt cagatagcgt tcaagcacaa gatccggcat ttgatgattc agcatggcaa      180

caagttgatc tgccgcatga ttatagcatc acacagaaat atagccaaag caatgaagca      240

gaatcagcat atcttccggg aggcacaggc tggtatagaa aaagctttac aattgataga      300

gatctggcag gcaaacgcat tgcgattaat tttgatggcg tctatatgaa tgcaacagtc      360

tggtttaatg gcgttaaact gggcacacat ccgtatggct attcaccgtt ttcatttgat      420

ctgacaggca atgcaaaatt tggcggagaa aacacaattg tcgtcaaagt tgaaaataga      480

ctgccgtcat caagatggta ttcaggcagc ggcatttata gagatgttac actgacagtt      540

acagatggcg ttcatgttgg caataatggc gtcgcaatta aaacaccgtc actggcaaca      600

caaaatggcg gagatgtcac aatgaacctg acaacaaaag tcgcgaatga tacagaagca      660

gcagcgaaca ttacactgaa acagacagtt tttccgaaag gcggaaaaac ggatgcagca      720

attggcacag ttacaacagc atcaaaatca attgcagcag gcgcatcagc agatgttaca      780

agcacaatta cagcagcaag cccgaaactg tggtcaatta aaaacccgaa cctgtataca      840

gttagaacag aagttctgaa cggaggcaaa gttctggata catatgatac agaatatggc      900

tttcgctgga caggctttga tgcaacatca ggcttttcac tgaatggcga aaaagtcaaa      960

ctgaaaggcg ttagcatgca tcatgatcaa ggctcacttg gcgcagttgc aaatagacgc     1020

gcaattgaaa gacaagtcga aatcctgcaa aaaatgggcg tcaatagcat tcgcacaaca     1080

cataatccgg cagcaaaagc actgattgat gtctgcaatg aaaaaggcgt tctggttgtc     1140

gaagaagtct ttgatatgtg gaaccgcagc aaaaatggca acacggaaga ttatggcaaa     1200

tggtttggcc aagcaattgc aggcgataat gcagttctgg gaggcgataa agatgaaaca     1260

tgggcgaaat ttgatcttac atcaacaatt aaccgcgata gaaatgcacc gtcagttatt     1320

atgtggtcac tgggcaatga aatgatggaa ggcatttcag gctcagtttc aggctttccg     1380

gcaacatcag caaaactggt tgcatggaca aaagcagcag attcaacaag accgatgaca     1440

tatggcgata acaaaattaa agcgaactgg aacgaatcaa atacaatggg cgataatctg     1500

acagcaaatg gcggagttgt tggcacaaat tattcagatg gcgcaaacta tgataaaatt     1560

cgtacaacac atccgtcatg ggcaatttat ggctcagaaa cagcatcagc gattaatagc     1620

cgtggcattt ataatagaac aacaggcgga gcacaatcat cagataaaca gctgacaagc     1680

tatgataatt cagcagttgg ctggggagca gttgcatcat cagcatggta tgatgttgtt     1740

cagagagatt ttgtcgcagg cacatatgtt tggacaggat ttgattatct gggcgaaccg     1800

acaccgtgga atggcacagg ctcaggcgca gttggctcat ggccgtcacc gaaaaatagc     1860

tattttggca tcgttgatac agcaggcttt ccgaaagata catattattt ttatcagagc     1920

cagtggaatg atgatgttca tacactgcat attcttccgg catggaatga aaatgttgtt     1980

gcaaaaggct caggcaataa tgttccggtt gtcgtttata cagatgcagc gaaagtgaaa     2040

ctgtatttta caccgaaagg ctcaacagaa aaaagactga tcggcgaaaa atcatttaca     2100

aaaaaaacaa cagcggcagg ctatacatat caagtctatg aaggcagcga taaagattca     2160

acagcgcata aaaacatgta tctgacatgg aatgttccgt gggcagaagg cacaatttca     2220

gcggaagcgt atgatgaaaa taatcgcctg attccggaag gcagcacaga aggcaacgca     2280

tcagttacaa caacaggcaa agcagcaaaa ctgaaagcag atgcggatcg caaaacaatt     2340

acagcggatg gcaaagatct gtcatatatt gaagtcgatg tcacagatgc aaatggccat     2400

attgttccgg atgcagcaaa tagagtcaca tttgatgtta aaggcgcagg caaactggtt     2460

ggcgttgata atggctcatc accggatcat gattcatatc aagcggataa ccgcaaagca     2520

ttttcaggca aagtcctggc aattgttcag tcaacaaaag aagcaggcga aattacagtt     2580

acagcaaaag cagatggcct gcaatcaagc acagttaaaa ttgcaacaac agcagttccg     2640

ggaacaagca cagaaaaaac agtccgcagc ttttattaca gccgcaacta ttatgtcaaa     2700

acaggcaaca aaccgattct gccgtcagat gttgaagttc gctattcaga tggaacaagc     2760

gatagacaaa acgttacatg ggatgcagtt tcagatgatc aaattgcaaa agcaggctca     2820

ttttcagttg caggcacagt tgcaggccaa aaaattagcg ttcgcgtcac aatgattgat     2880

gaaattggcg cactg                                                      2895


<210>  11
<211>  3114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding BIF_1068

<400>  11
gttgaagatg caacaagaag cgatagcaca acacaaatgt catcaacacc ggaagttgtt       60

tattcatcag cggtcgatag caaacaaaat cgcacaagcg attttgatgc gaactggaaa      120

tttatgctgt cagatagcgt tcaagcacaa gatccggcat ttgatgattc agcatggcaa      180

caagttgatc tgccgcatga ttatagcatc acacagaaat atagccaaag caatgaagca      240

gaatcagcat atcttccggg aggcacaggc tggtatagaa aaagctttac aattgataga      300

gatctggcag gcaaacgcat tgcgattaat tttgatggcg tctatatgaa tgcaacagtc      360

tggtttaatg gcgttaaact gggcacacat ccgtatggct attcaccgtt ttcatttgat      420

ctgacaggca atgcaaaatt tggcggagaa aacacaattg tcgtcaaagt tgaaaataga      480

ctgccgtcat caagatggta ttcaggcagc ggcatttata gagatgttac actgacagtt      540

acagatggcg ttcatgttgg caataatggc gtcgcaatta aaacaccgtc actggcaaca      600

caaaatggcg gagatgtcac aatgaacctg acaacaaaag tcgcgaatga tacagaagca      660

gcagcgaaca ttacactgaa acagacagtt tttccgaaag gcggaaaaac ggatgcagca      720

attggcacag ttacaacagc atcaaaatca attgcagcag gcgcatcagc agatgttaca      780

agcacaatta cagcagcaag cccgaaactg tggtcaatta aaaacccgaa cctgtataca      840

gttagaacag aagttctgaa cggaggcaaa gttctggata catatgatac agaatatggc      900

tttcgctgga caggctttga tgcaacatca ggcttttcac tgaatggcga aaaagtcaaa      960

ctgaaaggcg ttagcatgca tcatgatcaa ggctcacttg gcgcagttgc aaatagacgc     1020

gcaattgaaa gacaagtcga aatcctgcaa aaaatgggcg tcaatagcat tcgcacaaca     1080

cataatccgg cagcaaaagc actgattgat gtctgcaatg aaaaaggcgt tctggttgtc     1140

gaagaagtct ttgatatgtg gaaccgcagc aaaaatggca acacggaaga ttatggcaaa     1200

tggtttggcc aagcaattgc aggcgataat gcagttctgg gaggcgataa agatgaaaca     1260

tgggcgaaat ttgatcttac atcaacaatt aaccgcgata gaaatgcacc gtcagttatt     1320

atgtggtcac tgggcaatga aatgatggaa ggcatttcag gctcagtttc aggctttccg     1380

gcaacatcag caaaactggt tgcatggaca aaagcagcag attcaacaag accgatgaca     1440

tatggcgata acaaaattaa agcgaactgg aacgaatcaa atacaatggg cgataatctg     1500

acagcaaatg gcggagttgt tggcacaaat tattcagatg gcgcaaacta tgataaaatt     1560

cgtacaacac atccgtcatg ggcaatttat ggctcagaaa cagcatcagc gattaatagc     1620

cgtggcattt ataatagaac aacaggcgga gcacaatcat cagataaaca gctgacaagc     1680

tatgataatt cagcagttgg ctggggagca gttgcatcat cagcatggta tgatgttgtt     1740

cagagagatt ttgtcgcagg cacatatgtt tggacaggat ttgattatct gggcgaaccg     1800

acaccgtgga atggcacagg ctcaggcgca gttggctcat ggccgtcacc gaaaaatagc     1860

tattttggca tcgttgatac agcaggcttt ccgaaagata catattattt ttatcagagc     1920

cagtggaatg atgatgttca tacactgcat attcttccgg catggaatga aaatgttgtt     1980

gcaaaaggct caggcaataa tgttccggtt gtcgtttata cagatgcagc gaaagtgaaa     2040

ctgtatttta caccgaaagg ctcaacagaa aaaagactga tcggcgaaaa atcatttaca     2100

aaaaaaacaa cagcggcagg ctatacatat caagtctatg aaggcagcga taaagattca     2160

acagcgcata aaaacatgta tctgacatgg aatgttccgt gggcagaagg cacaatttca     2220

gcggaagcgt atgatgaaaa taatcgcctg attccggaag gcagcacaga aggcaacgca     2280

tcagttacaa caacaggcaa agcagcaaaa ctgaaagcag atgcggatcg caaaacaatt     2340

acagcggatg gcaaagatct gtcatatatt gaagtcgatg tcacagatgc aaatggccat     2400

attgttccgg atgcagcaaa tagagtcaca tttgatgtta aaggcgcagg caaactggtt     2460

ggcgttgata atggctcatc accggatcat gattcatatc aagcggataa ccgcaaagca     2520

ttttcaggca aagtcctggc aattgttcag tcaacaaaag aagcaggcga aattacagtt     2580

acagcaaaag cagatggcct gcaatcaagc acagttaaaa ttgcaacaac agcagttccg     2640

ggaacaagca cagaaaaaac agtccgcagc ttttattaca gccgcaacta ttatgtcaaa     2700

acaggcaaca aaccgattct gccgtcagat gttgaagttc gctattcaga tggaacaagc     2760

gatagacaaa acgttacatg ggatgcagtt tcagatgatc aaattgcaaa agcaggctca     2820

ttttcagttg caggcacagt tgcaggccaa aaaattagcg ttcgcgtcac aatgattgat     2880

gaaattggcg cactgctgaa ttattcagca agcacaccgg ttggcacacc ggcagttctt     2940

ccgggatcaa gaccggcagt cctgccggat ggcacagtca catcagcaaa ttttgcagtc     3000

cattggacaa aaccggcaga tacagtctat aatacagcag gcacagtcaa agtaccggga     3060

acagcaacag tttttggcaa agaatttaaa gtcacagcga caattagagt tcaa           3114


<210>  12
<211>  3426
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding BIF_1172

<400>  12
gttgaagatg caacaagaag cgatagcaca acacaaatgt catcaacacc ggaagttgtt       60

tattcatcag cggtcgatag caaacaaaat cgcacaagcg attttgatgc gaactggaaa      120

tttatgctgt cagatagcgt tcaagcacaa gatccggcat ttgatgattc agcatggcaa      180

caagttgatc tgccgcatga ttatagcatc acacagaaat atagccaaag caatgaagca      240

gaatcagcat atcttccggg aggcacaggc tggtatagaa aaagctttac aattgataga      300

gatctggcag gcaaacgcat tgcgattaat tttgatggcg tctatatgaa tgcaacagtc      360

tggtttaatg gcgttaaact gggcacacat ccgtatggct attcaccgtt ttcatttgat      420

ctgacaggca atgcaaaatt tggcggagaa aacacaattg tcgtcaaagt tgaaaataga      480

ctgccgtcat caagatggta ttcaggcagc ggcatttata gagatgttac actgacagtt      540

acagatggcg ttcatgttgg caataatggc gtcgcaatta aaacaccgtc actggcaaca      600

caaaatggcg gagatgtcac aatgaacctg acaacaaaag tcgcgaatga tacagaagca      660

gcagcgaaca ttacactgaa acagacagtt tttccgaaag gcggaaaaac ggatgcagca      720

attggcacag ttacaacagc atcaaaatca attgcagcag gcgcatcagc agatgttaca      780

agcacaatta cagcagcaag cccgaaactg tggtcaatta aaaacccgaa cctgtataca      840

gttagaacag aagttctgaa cggaggcaaa gttctggata catatgatac agaatatggc      900

tttcgctgga caggctttga tgcaacatca ggcttttcac tgaatggcga aaaagtcaaa      960

ctgaaaggcg ttagcatgca tcatgatcaa ggctcacttg gcgcagttgc aaatagacgc     1020

gcaattgaaa gacaagtcga aatcctgcaa aaaatgggcg tcaatagcat tcgcacaaca     1080

cataatccgg cagcaaaagc actgattgat gtctgcaatg aaaaaggcgt tctggttgtc     1140

gaagaagtct ttgatatgtg gaaccgcagc aaaaatggca acacggaaga ttatggcaaa     1200

tggtttggcc aagcaattgc aggcgataat gcagttctgg gaggcgataa agatgaaaca     1260

tgggcgaaat ttgatcttac atcaacaatt aaccgcgata gaaatgcacc gtcagttatt     1320

atgtggtcac tgggcaatga aatgatggaa ggcatttcag gctcagtttc aggctttccg     1380

gcaacatcag caaaactggt tgcatggaca aaagcagcag attcaacaag accgatgaca     1440

tatggcgata acaaaattaa agcgaactgg aacgaatcaa atacaatggg cgataatctg     1500

acagcaaatg gcggagttgt tggcacaaat tattcagatg gcgcaaacta tgataaaatt     1560

cgtacaacac atccgtcatg ggcaatttat ggctcagaaa cagcatcagc gattaatagc     1620

cgtggcattt ataatagaac aacaggcgga gcacaatcat cagataaaca gctgacaagc     1680

tatgataatt cagcagttgg ctggggagca gttgcatcat cagcatggta tgatgttgtt     1740

cagagagatt ttgtcgcagg cacatatgtt tggacaggat ttgattatct gggcgaaccg     1800

acaccgtgga atggcacagg ctcaggcgca gttggctcat ggccgtcacc gaaaaatagc     1860

tattttggca tcgttgatac agcaggcttt ccgaaagata catattattt ttatcagagc     1920

cagtggaatg atgatgttca tacactgcat attcttccgg catggaatga aaatgttgtt     1980

gcaaaaggct caggcaataa tgttccggtt gtcgtttata cagatgcagc gaaagtgaaa     2040

ctgtatttta caccgaaagg ctcaacagaa aaaagactga tcggcgaaaa atcatttaca     2100

aaaaaaacaa cagcggcagg ctatacatat caagtctatg aaggcagcga taaagattca     2160

acagcgcata aaaacatgta tctgacatgg aatgttccgt gggcagaagg cacaatttca     2220

gcggaagcgt atgatgaaaa taatcgcctg attccggaag gcagcacaga aggcaacgca     2280

tcagttacaa caacaggcaa agcagcaaaa ctgaaagcag atgcggatcg caaaacaatt     2340

acagcggatg gcaaagatct gtcatatatt gaagtcgatg tcacagatgc aaatggccat     2400

attgttccgg atgcagcaaa tagagtcaca tttgatgtta aaggcgcagg caaactggtt     2460

ggcgttgata atggctcatc accggatcat gattcatatc aagcggataa ccgcaaagca     2520

ttttcaggca aagtcctggc aattgttcag tcaacaaaag aagcaggcga aattacagtt     2580

acagcaaaag cagatggcct gcaatcaagc acagttaaaa ttgcaacaac agcagttccg     2640

ggaacaagca cagaaaaaac agtccgcagc ttttattaca gccgcaacta ttatgtcaaa     2700

acaggcaaca aaccgattct gccgtcagat gttgaagttc gctattcaga tggaacaagc     2760

gatagacaaa acgttacatg ggatgcagtt tcagatgatc aaattgcaaa agcaggctca     2820

ttttcagttg caggcacagt tgcaggccaa aaaattagcg ttcgcgtcac aatgattgat     2880

gaaattggcg cactgctgaa ttattcagca agcacaccgg ttggcacacc ggcagttctt     2940

ccgggatcaa gaccggcagt cctgccggat ggcacagtca catcagcaaa ttttgcagtc     3000

cattggacaa aaccggcaga tacagtctat aatacagcag gcacagtcaa agtaccggga     3060

acagcaacag tttttggcaa agaatttaaa gtcacagcga caattagagt tcaaagaagc     3120

caagttacaa ttggctcatc agtttcagga aatgcactga gactgacaca aaatattccg     3180

gcagataaac aatcagatac actggatgcg attaaagatg gctcaacaac agttgatgca     3240

aatacaggcg gaggcgcaaa tccgtcagca tggacaaatt gggcatattc aaaagcaggc     3300

cataacacag cggaaattac atttgaatat gcgacagaac aacaactggg ccagatcgtc     3360

atgtattttt ttcgcgatag caatgcagtt agatttccgg atgctggcaa aacaaaaatt     3420

cagatc                                                                3426


<210>  13
<211>  3633
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding BIF_1241

<400>  13
gttgaagatg caacaagaag cgatagcaca acacaaatgt catcaacacc ggaagttgtt       60

tattcatcag cggtcgatag caaacaaaat cgcacaagcg attttgatgc gaactggaaa      120

tttatgctgt cagatagcgt tcaagcacaa gatccggcat ttgatgattc agcatggcaa      180

caagttgatc tgccgcatga ttatagcatc acacagaaat atagccaaag caatgaagca      240

gaatcagcat atcttccggg aggcacaggc tggtatagaa aaagctttac aattgataga      300

gatctggcag gcaaacgcat tgcgattaat tttgatggcg tctatatgaa tgcaacagtc      360

tggtttaatg gcgttaaact gggcacacat ccgtatggct attcaccgtt ttcatttgat      420

ctgacaggca atgcaaaatt tggcggagaa aacacaattg tcgtcaaagt tgaaaataga      480

ctgccgtcat caagatggta ttcaggcagc ggcatttata gagatgttac actgacagtt      540

acagatggcg ttcatgttgg caataatggc gtcgcaatta aaacaccgtc actggcaaca      600

caaaatggcg gagatgtcac aatgaacctg acaacaaaag tcgcgaatga tacagaagca      660

gcagcgaaca ttacactgaa acagacagtt tttccgaaag gcggaaaaac ggatgcagca      720

attggcacag ttacaacagc atcaaaatca attgcagcag gcgcatcagc agatgttaca      780

agcacaatta cagcagcaag cccgaaactg tggtcaatta aaaacccgaa cctgtataca      840

gttagaacag aagttctgaa cggaggcaaa gttctggata catatgatac agaatatggc      900

tttcgctgga caggctttga tgcaacatca ggcttttcac tgaatggcga aaaagtcaaa      960

ctgaaaggcg ttagcatgca tcatgatcaa ggctcacttg gcgcagttgc aaatagacgc     1020

gcaattgaaa gacaagtcga aatcctgcaa aaaatgggcg tcaatagcat tcgcacaaca     1080

cataatccgg cagcaaaagc actgattgat gtctgcaatg aaaaaggcgt tctggttgtc     1140

gaagaagtct ttgatatgtg gaaccgcagc aaaaatggca acacggaaga ttatggcaaa     1200

tggtttggcc aagcaattgc aggcgataat gcagttctgg gaggcgataa agatgaaaca     1260

tgggcgaaat ttgatcttac atcaacaatt aaccgcgata gaaatgcacc gtcagttatt     1320

atgtggtcac tgggcaatga aatgatggaa ggcatttcag gctcagtttc aggctttccg     1380

gcaacatcag caaaactggt tgcatggaca aaagcagcag attcaacaag accgatgaca     1440

tatggcgata acaaaattaa agcgaactgg aacgaatcaa atacaatggg cgataatctg     1500

acagcaaatg gcggagttgt tggcacaaat tattcagatg gcgcaaacta tgataaaatt     1560

cgtacaacac atccgtcatg ggcaatttat ggctcagaaa cagcatcagc gattaatagc     1620

cgtggcattt ataatagaac aacaggcgga gcacaatcat cagataaaca gctgacaagc     1680

tatgataatt cagcagttgg ctggggagca gttgcatcat cagcatggta tgatgttgtt     1740

cagagagatt ttgtcgcagg cacatatgtt tggacaggat ttgattatct gggcgaaccg     1800

acaccgtgga atggcacagg ctcaggcgca gttggctcat ggccgtcacc gaaaaatagc     1860

tattttggca tcgttgatac agcaggcttt ccgaaagata catattattt ttatcagagc     1920

cagtggaatg atgatgttca tacactgcat attcttccgg catggaatga aaatgttgtt     1980

gcaaaaggct caggcaataa tgttccggtt gtcgtttata cagatgcagc gaaagtgaaa     2040

ctgtatttta caccgaaagg ctcaacagaa aaaagactga tcggcgaaaa atcatttaca     2100

aaaaaaacaa cagcggcagg ctatacatat caagtctatg aaggcagcga taaagattca     2160

acagcgcata aaaacatgta tctgacatgg aatgttccgt gggcagaagg cacaatttca     2220

gcggaagcgt atgatgaaaa taatcgcctg attccggaag gcagcacaga aggcaacgca     2280

tcagttacaa caacaggcaa agcagcaaaa ctgaaagcag atgcggatcg caaaacaatt     2340

acagcggatg gcaaagatct gtcatatatt gaagtcgatg tcacagatgc aaatggccat     2400

attgttccgg atgcagcaaa tagagtcaca tttgatgtta aaggcgcagg caaactggtt     2460

ggcgttgata atggctcatc accggatcat gattcatatc aagcggataa ccgcaaagca     2520

ttttcaggca aagtcctggc aattgttcag tcaacaaaag aagcaggcga aattacagtt     2580

acagcaaaag cagatggcct gcaatcaagc acagttaaaa ttgcaacaac agcagttccg     2640

ggaacaagca cagaaaaaac agtccgcagc ttttattaca gccgcaacta ttatgtcaaa     2700

acaggcaaca aaccgattct gccgtcagat gttgaagttc gctattcaga tggaacaagc     2760

gatagacaaa acgttacatg ggatgcagtt tcagatgatc aaattgcaaa agcaggctca     2820

ttttcagttg caggcacagt tgcaggccaa aaaattagcg ttcgcgtcac aatgattgat     2880

gaaattggcg cactgctgaa ttattcagca agcacaccgg ttggcacacc ggcagttctt     2940

ccgggatcaa gaccggcagt cctgccggat ggcacagtca catcagcaaa ttttgcagtc     3000

cattggacaa aaccggcaga tacagtctat aatacagcag gcacagtcaa agtaccggga     3060

acagcaacag tttttggcaa agaatttaaa gtcacagcga caattagagt tcaaagaagc     3120

caagttacaa ttggctcatc agtttcagga aatgcactga gactgacaca aaatattccg     3180

gcagataaac aatcagatac actggatgcg attaaagatg gctcaacaac agttgatgca     3240

aatacaggcg gaggcgcaaa tccgtcagca tggacaaatt gggcatattc aaaagcaggc     3300

cataacacag cggaaattac atttgaatat gcgacagaac aacaactggg ccagatcgtc     3360

atgtattttt ttcgcgatag caatgcagtt agatttccgg atgctggcaa aacaaaaatt     3420

cagatcagcg cagatggcaa aaattggaca gatctggcag caacagaaac aattgcagcg     3480

caagaatcaa gcgatagagt caaaccgtat acatatgatt ttgcaccggt tggcgcaaca     3540

tttgttaaag tgacagtcac aaacgcagat acaacaacac cgtcaggcgt tgtttgcgca     3600

ggcctgacag aaattgaact gaaaacagcg aca                                  3633


<210>  14
<211>  3888
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding BIF_1326

<400>  14
gttgaagatg caacaagaag cgatagcaca acacaaatgt catcaacacc ggaagttgtt       60

tattcatcag cggtcgatag caaacaaaat cgcacaagcg attttgatgc gaactggaaa      120

tttatgctgt cagatagcgt tcaagcacaa gatccggcat ttgatgattc agcatggcaa      180

caagttgatc tgccgcatga ttatagcatc acacagaaat atagccaaag caatgaagca      240

gaatcagcat atcttccggg aggcacaggc tggtatagaa aaagctttac aattgataga      300

gatctggcag gcaaacgcat tgcgattaat tttgatggcg tctatatgaa tgcaacagtc      360

tggtttaatg gcgttaaact gggcacacat ccgtatggct attcaccgtt ttcatttgat      420

ctgacaggca atgcaaaatt tggcggagaa aacacaattg tcgtcaaagt tgaaaataga      480

ctgccgtcat caagatggta ttcaggcagc ggcatttata gagatgttac actgacagtt      540

acagatggcg ttcatgttgg caataatggc gtcgcaatta aaacaccgtc actggcaaca      600

caaaatggcg gagatgtcac aatgaacctg acaacaaaag tcgcgaatga tacagaagca      660

gcagcgaaca ttacactgaa acagacagtt tttccgaaag gcggaaaaac ggatgcagca      720

attggcacag ttacaacagc atcaaaatca attgcagcag gcgcatcagc agatgttaca      780

agcacaatta cagcagcaag cccgaaactg tggtcaatta aaaacccgaa cctgtataca      840

gttagaacag aagttctgaa cggaggcaaa gttctggata catatgatac agaatatggc      900

tttcgctgga caggctttga tgcaacatca ggcttttcac tgaatggcga aaaagtcaaa      960

ctgaaaggcg ttagcatgca tcatgatcaa ggctcacttg gcgcagttgc aaatagacgc     1020

gcaattgaaa gacaagtcga aatcctgcaa aaaatgggcg tcaatagcat tcgcacaaca     1080

cataatccgg cagcaaaagc actgattgat gtctgcaatg aaaaaggcgt tctggttgtc     1140

gaagaagtct ttgatatgtg gaaccgcagc aaaaatggca acacggaaga ttatggcaaa     1200

tggtttggcc aagcaattgc aggcgataat gcagttctgg gaggcgataa agatgaaaca     1260

tgggcgaaat ttgatcttac atcaacaatt aaccgcgata gaaatgcacc gtcagttatt     1320

atgtggtcac tgggcaatga aatgatggaa ggcatttcag gctcagtttc aggctttccg     1380

gcaacatcag caaaactggt tgcatggaca aaagcagcag attcaacaag accgatgaca     1440

tatggcgata acaaaattaa agcgaactgg aacgaatcaa atacaatggg cgataatctg     1500

acagcaaatg gcggagttgt tggcacaaat tattcagatg gcgcaaacta tgataaaatt     1560

cgtacaacac atccgtcatg ggcaatttat ggctcagaaa cagcatcagc gattaatagc     1620

cgtggcattt ataatagaac aacaggcgga gcacaatcat cagataaaca gctgacaagc     1680

tatgataatt cagcagttgg ctggggagca gttgcatcat cagcatggta tgatgttgtt     1740

cagagagatt ttgtcgcagg cacatatgtt tggacaggat ttgattatct gggcgaaccg     1800

acaccgtgga atggcacagg ctcaggcgca gttggctcat ggccgtcacc gaaaaatagc     1860

tattttggca tcgttgatac agcaggcttt ccgaaagata catattattt ttatcagagc     1920

cagtggaatg atgatgttca tacactgcat attcttccgg catggaatga aaatgttgtt     1980

gcaaaaggct caggcaataa tgttccggtt gtcgtttata cagatgcagc gaaagtgaaa     2040

ctgtatttta caccgaaagg ctcaacagaa aaaagactga tcggcgaaaa atcatttaca     2100

aaaaaaacaa cagcggcagg ctatacatat caagtctatg aaggcagcga taaagattca     2160

acagcgcata aaaacatgta tctgacatgg aatgttccgt gggcagaagg cacaatttca     2220

gcggaagcgt atgatgaaaa taatcgcctg attccggaag gcagcacaga aggcaacgca     2280

tcagttacaa caacaggcaa agcagcaaaa ctgaaagcag atgcggatcg caaaacaatt     2340

acagcggatg gcaaagatct gtcatatatt gaagtcgatg tcacagatgc aaatggccat     2400

attgttccgg atgcagcaaa tagagtcaca tttgatgtta aaggcgcagg caaactggtt     2460

ggcgttgata atggctcatc accggatcat gattcatatc aagcggataa ccgcaaagca     2520

ttttcaggca aagtcctggc aattgttcag tcaacaaaag aagcaggcga aattacagtt     2580

acagcaaaag cagatggcct gcaatcaagc acagttaaaa ttgcaacaac agcagttccg     2640

ggaacaagca cagaaaaaac agtccgcagc ttttattaca gccgcaacta ttatgtcaaa     2700

acaggcaaca aaccgattct gccgtcagat gttgaagttc gctattcaga tggaacaagc     2760

gatagacaaa acgttacatg ggatgcagtt tcagatgatc aaattgcaaa agcaggctca     2820

ttttcagttg caggcacagt tgcaggccaa aaaattagcg ttcgcgtcac aatgattgat     2880

gaaattggcg cactgctgaa ttattcagca agcacaccgg ttggcacacc ggcagttctt     2940

ccgggatcaa gaccggcagt cctgccggat ggcacagtca catcagcaaa ttttgcagtc     3000

cattggacaa aaccggcaga tacagtctat aatacagcag gcacagtcaa agtaccggga     3060

acagcaacag tttttggcaa agaatttaaa gtcacagcga caattagagt tcaaagaagc     3120

caagttacaa ttggctcatc agtttcagga aatgcactga gactgacaca aaatattccg     3180

gcagataaac aatcagatac actggatgcg attaaagatg gctcaacaac agttgatgca     3240

aatacaggcg gaggcgcaaa tccgtcagca tggacaaatt gggcatattc aaaagcaggc     3300

cataacacag cggaaattac atttgaatat gcgacagaac aacaactggg ccagatcgtc     3360

atgtattttt ttcgcgatag caatgcagtt agatttccgg atgctggcaa aacaaaaatt     3420

cagatcagcg cagatggcaa aaattggaca gatctggcag caacagaaac aattgcagcg     3480

caagaatcaa gcgatagagt caaaccgtat acatatgatt ttgcaccggt tggcgcaaca     3540

tttgttaaag tgacagtcac aaacgcagat acaacaacac cgtcaggcgt tgtttgcgca     3600

ggcctgacag aaattgaact gaaaacagcg acaagcaaat ttgtcacaaa tacatcagca     3660

gcactgtcat cacttacagt caatggcaca aaagtttcag attcagttct ggcagcaggc     3720

tcatataaca caccggcaat tatcgcagat gttaaagcgg aaggcgaagg caatgcaagc     3780

gttacagtcc ttccggcaca tgataatgtt attcgcgtca ttacagaaag cgaagatcat     3840

gtcacacgca aaacatttac aatcaacctg ggcacagaac aagaattt                  3888


<210>  15
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer for generation of BIF variants

<400>  15
ggggtaacta gtggaagatg caacaagaag                                        30


<210>  16
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for BIF917

<400>  16
gcgcttaatt aattatgttt tttctgtgct tgttc                                  35


<210>  17
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for BIF995

<400>  17
gcgcttaatt aattacagtg cgccaatttc atcaatca                               38


<210>  18
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for BIF1068

<400>  18
gcgcttaatt aattattgaa ctctaattgt cgctg                                  35


<210>  19
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for BIF1241

<400>  19
gcgcttaatt aattatgtcg ctgttttcag ttcaat                                 36


<210>  20
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for BIF1326

<400>  20
gcgcttaatt aattaaaatt cttgttctgt gccca                                  35


<210>  21
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for BIF1478

<400>  21
gcgcttaatt aattatctca gtctaatttc gcttgcgc                               38


<210>  22
<211>  1720
<212>  PRT
<213>  Bifidobacterium bifidum

<400>  22

Val Glu Asp Ala Thr Arg Ser Asp Ser Thr Thr Gln Met Ser Ser Thr 
1               5                   10                  15      


Pro Glu Val Val Tyr Ser Ser Ala Val Asp Ser Lys Gln Asn Arg Thr 
            20                  25                  30          


Ser Asp Phe Asp Ala Asn Trp Lys Phe Met Leu Ser Asp Ser Val Gln 
        35                  40                  45              


Ala Gln Asp Pro Ala Phe Asp Asp Ser Ala Trp Gln Gln Val Asp Leu 
    50                  55                  60                  


Pro His Asp Tyr Ser Ile Thr Gln Lys Tyr Ser Gln Ser Asn Glu Ala 
65                  70                  75                  80  


Glu Ser Ala Tyr Leu Pro Gly Gly Thr Gly Trp Tyr Arg Lys Ser Phe 
                85                  90                  95      


Thr Ile Asp Arg Asp Leu Ala Gly Lys Arg Ile Ala Ile Asn Phe Asp 
            100                 105                 110         


Gly Val Tyr Met Asn Ala Thr Val Trp Phe Asn Gly Val Lys Leu Gly 
        115                 120                 125             


Thr His Pro Tyr Gly Tyr Ser Pro Phe Ser Phe Asp Leu Thr Gly Asn 
    130                 135                 140                 


Ala Lys Phe Gly Gly Glu Asn Thr Ile Val Val Lys Val Glu Asn Arg 
145                 150                 155                 160 


Leu Pro Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val 
                165                 170                 175     


Thr Leu Thr Val Thr Asp Gly Val His Val Gly Asn Asn Gly Val Ala 
            180                 185                 190         


Ile Lys Thr Pro Ser Leu Ala Thr Gln Asn Gly Gly Asp Val Thr Met 
        195                 200                 205             


Asn Leu Thr Thr Lys Val Ala Asn Asp Thr Glu Ala Ala Ala Asn Ile 
    210                 215                 220                 


Thr Leu Lys Gln Thr Val Phe Pro Lys Gly Gly Lys Thr Asp Ala Ala 
225                 230                 235                 240 


Ile Gly Thr Val Thr Thr Ala Ser Lys Ser Ile Ala Ala Gly Ala Ser 
                245                 250                 255     


Ala Asp Val Thr Ser Thr Ile Thr Ala Ala Ser Pro Lys Leu Trp Ser 
            260                 265                 270         


Ile Lys Asn Pro Asn Leu Tyr Thr Val Arg Thr Glu Val Leu Asn Gly 
        275                 280                 285             


Gly Lys Val Leu Asp Thr Tyr Asp Thr Glu Tyr Gly Phe Arg Trp Thr 
    290                 295                 300                 


Gly Phe Asp Ala Thr Ser Gly Phe Ser Leu Asn Gly Glu Lys Val Lys 
305                 310                 315                 320 


Leu Lys Gly Val Ser Met His His Asp Gln Gly Ser Leu Gly Ala Val 
                325                 330                 335     


Ala Asn Arg Arg Ala Ile Glu Arg Gln Val Glu Ile Leu Gln Lys Met 
            340                 345                 350         


Gly Val Asn Ser Ile Arg Thr Thr His Asn Pro Ala Ala Lys Ala Leu 
        355                 360                 365             


Ile Asp Val Cys Asn Glu Lys Gly Val Leu Val Val Glu Glu Val Phe 
    370                 375                 380                 


Asp Met Trp Asn Arg Ser Lys Asn Gly Asn Thr Glu Asp Tyr Gly Lys 
385                 390                 395                 400 


Trp Phe Gly Gln Ala Ile Ala Gly Asp Asn Ala Val Leu Gly Gly Asp 
                405                 410                 415     


Lys Asp Glu Thr Trp Ala Lys Phe Asp Leu Thr Ser Thr Ile Asn Arg 
            420                 425                 430         


Asp Arg Asn Ala Pro Ser Val Ile Met Trp Ser Leu Gly Asn Glu Met 
        435                 440                 445             


Met Glu Gly Ile Ser Gly Ser Val Ser Gly Phe Pro Ala Thr Ser Ala 
    450                 455                 460                 


Lys Leu Val Ala Trp Thr Lys Ala Ala Asp Ser Thr Arg Pro Met Thr 
465                 470                 475                 480 


Tyr Gly Asp Asn Lys Ile Lys Ala Asn Trp Asn Glu Ser Asn Thr Met 
                485                 490                 495     


Gly Asp Asn Leu Thr Ala Asn Gly Gly Val Val Gly Thr Asn Tyr Ser 
            500                 505                 510         


Asp Gly Ala Asn Tyr Asp Lys Ile Arg Thr Thr His Pro Ser Trp Ala 
        515                 520                 525             


Ile Tyr Gly Ser Glu Thr Ala Ser Ala Ile Asn Ser Arg Gly Ile Tyr 
    530                 535                 540                 


Asn Arg Thr Thr Gly Gly Ala Gln Ser Ser Asp Lys Gln Leu Thr Ser 
545                 550                 555                 560 


Tyr Asp Asn Ser Ala Val Gly Trp Gly Ala Val Ala Ser Ser Ala Trp 
                565                 570                 575     


Tyr Asp Val Val Gln Arg Asp Phe Val Ala Gly Thr Tyr Val Trp Thr 
            580                 585                 590         


Gly Phe Asp Tyr Leu Gly Glu Pro Thr Pro Trp Asn Gly Thr Gly Ser 
        595                 600                 605             


Gly Ala Val Gly Ser Trp Pro Ser Pro Lys Asn Ser Tyr Phe Gly Ile 
    610                 615                 620                 


Val Asp Thr Ala Gly Phe Pro Lys Asp Thr Tyr Tyr Phe Tyr Gln Ser 
625                 630                 635                 640 


Gln Trp Asn Asp Asp Val His Thr Leu His Ile Leu Pro Ala Trp Asn 
                645                 650                 655     


Glu Asn Val Val Ala Lys Gly Ser Gly Asn Asn Val Pro Val Val Val 
            660                 665                 670         


Tyr Thr Asp Ala Ala Lys Val Lys Leu Tyr Phe Thr Pro Lys Gly Ser 
        675                 680                 685             


Thr Glu Lys Arg Leu Ile Gly Glu Lys Ser Phe Thr Lys Lys Thr Thr 
    690                 695                 700                 


Ala Ala Gly Tyr Thr Tyr Gln Val Tyr Glu Gly Ser Asp Lys Asp Ser 
705                 710                 715                 720 


Thr Ala His Lys Asn Met Tyr Leu Thr Trp Asn Val Pro Trp Ala Glu 
                725                 730                 735     


Gly Thr Ile Ser Ala Glu Ala Tyr Asp Glu Asn Asn Arg Leu Ile Pro 
            740                 745                 750         


Glu Gly Ser Thr Glu Gly Asn Ala Ser Val Thr Thr Thr Gly Lys Ala 
        755                 760                 765             


Ala Lys Leu Lys Ala Asp Ala Asp Arg Lys Thr Ile Thr Ala Asp Gly 
    770                 775                 780                 


Lys Asp Leu Ser Tyr Ile Glu Val Asp Val Thr Asp Ala Asn Gly His 
785                 790                 795                 800 


Ile Val Pro Asp Ala Ala Asn Arg Val Thr Phe Asp Val Lys Gly Ala 
                805                 810                 815     


Gly Lys Leu Val Gly Val Asp Asn Gly Ser Ser Pro Asp His Asp Ser 
            820                 825                 830         


Tyr Gln Ala Asp Asn Arg Lys Ala Phe Ser Gly Lys Val Leu Ala Ile 
        835                 840                 845             


Val Gln Ser Thr Lys Glu Ala Gly Glu Ile Thr Val Thr Ala Lys Ala 
    850                 855                 860                 


Asp Gly Leu Gln Ser Ser Thr Val Lys Ile Ala Thr Thr Ala Val Pro 
865                 870                 875                 880 


Gly Thr Ser Thr Glu Lys Thr Val Arg Ser Phe Tyr Tyr Ser Arg Asn 
                885                 890                 895     


Tyr Tyr Val Lys Thr Gly Asn Lys Pro Ile Leu Pro Ser Asp Val Glu 
            900                 905                 910         


Val Arg Tyr Ser Asp Gly Thr Ser Asp Arg Gln Asn Val Thr Trp Asp 
        915                 920                 925             


Ala Val Ser Asp Asp Gln Ile Ala Lys Ala Gly Ser Phe Ser Val Ala 
    930                 935                 940                 


Gly Thr Val Ala Gly Gln Lys Ile Ser Val Arg Val Thr Met Ile Asp 
945                 950                 955                 960 


Glu Ile Gly Ala Leu Leu Asn Tyr Ser Ala Ser Thr Pro Val Gly Thr 
                965                 970                 975     


Pro Ala Val Leu Pro Gly Ser Arg Pro Ala Val Leu Pro Asp Gly Thr 
            980                 985                 990         


Val Thr Ser Ala Asn Phe Ala Val  His Trp Thr Lys Pro  Ala Asp Thr 
        995                 1000                 1005             


Val Tyr  Asn Thr Ala Gly Thr  Val Lys Val Pro Gly  Thr Ala Thr 
    1010                 1015                 1020             


Val Phe  Gly Lys Glu Phe Lys  Val Thr Ala Thr Ile  Arg Val Gln 
    1025                 1030                 1035             


Arg Ser  Gln Val Thr Ile Gly  Ser Ser Val Ser Gly  Asn Ala Leu 
    1040                 1045                 1050             


Arg Leu  Thr Gln Asn Ile Pro  Ala Asp Lys Gln Ser  Asp Thr Leu 
    1055                 1060                 1065             


Asp Ala  Ile Lys Asp Gly Ser  Thr Thr Val Asp Ala  Asn Thr Gly 
    1070                 1075                 1080             


Gly Gly  Ala Asn Pro Ser Ala  Trp Thr Asn Trp Ala  Tyr Ser Lys 
    1085                 1090                 1095             


Ala Gly  His Asn Thr Ala Glu  Ile Thr Phe Glu Tyr  Ala Thr Glu 
    1100                 1105                 1110             


Gln Gln  Leu Gly Gln Ile Val  Met Tyr Phe Phe Arg  Asp Ser Asn 
    1115                 1120                 1125             


Ala Val  Arg Phe Pro Asp Ala  Gly Lys Thr Lys Ile  Gln Ile Ser 
    1130                 1135                 1140             


Ala Asp  Gly Lys Asn Trp Thr  Asp Leu Ala Ala Thr  Glu Thr Ile 
    1145                 1150                 1155             


Ala Ala  Gln Glu Ser Ser Asp  Arg Val Lys Pro Tyr  Thr Tyr Asp 
    1160                 1165                 1170             


Phe Ala  Pro Val Gly Ala Thr  Phe Val Lys Val Thr  Val Thr Asn 
    1175                 1180                 1185             


Ala Asp  Thr Thr Thr Pro Ser  Gly Val Val Cys Ala  Gly Leu Thr 
    1190                 1195                 1200             


Glu Ile  Glu Leu Lys Thr Ala  Thr Ser Lys Phe Val  Thr Asn Thr 
    1205                 1210                 1215             


Ser Ala  Ala Leu Ser Ser Leu  Thr Val Asn Gly Thr  Lys Val Ser 
    1220                 1225                 1230             


Asp Ser  Val Leu Ala Ala Gly  Ser Tyr Asn Thr Pro  Ala Ile Ile 
    1235                 1240                 1245             


Ala Asp  Val Lys Ala Glu Gly  Glu Gly Asn Ala Ser  Val Thr Val 
    1250                 1255                 1260             


Leu Pro  Ala His Asp Asn Val  Ile Arg Val Ile Thr  Glu Ser Glu 
    1265                 1270                 1275             


Asp His  Val Thr Arg Lys Thr  Phe Thr Ile Asn Leu  Gly Thr Glu 
    1280                 1285                 1290             


Gln Glu  Phe Pro Ala Asp Ser  Asp Glu Arg Asp Tyr  Pro Ala Ala 
    1295                 1300                 1305             


Asp Met  Thr Val Thr Val Gly  Ser Glu Gln Thr Ser  Gly Thr Ala 
    1310                 1315                 1320             


Thr Glu  Gly Pro Lys Lys Phe  Ala Val Asp Gly Asn  Thr Ser Thr 
    1325                 1330                 1335             


Tyr Trp  His Ser Asn Trp Thr  Pro Thr Thr Val Asn  Asp Leu Trp 
    1340                 1345                 1350             


Ile Ala  Phe Glu Leu Gln Lys  Pro Thr Lys Leu Asp  Ala Leu Arg 
    1355                 1360                 1365             


Tyr Leu  Pro Arg Pro Ala Gly  Ser Lys Asn Gly Ser  Val Thr Glu 
    1370                 1375                 1380             


Tyr Lys  Val Gln Val Ser Asp  Asp Gly Thr Asn Trp  Thr Asp Ala 
    1385                 1390                 1395             


Gly Ser  Gly Thr Trp Thr Thr  Asp Tyr Gly Trp Lys  Leu Ala Glu 
    1400                 1405                 1410             


Phe Asn  Gln Pro Val Thr Thr  Lys His Val Arg Leu  Lys Ala Val 
    1415                 1420                 1425             


His Thr  Tyr Ala Asp Ser Gly  Asn Asp Lys Phe Met  Ser Ala Ser 
    1430                 1435                 1440             


Glu Ile  Arg Leu Arg Lys Ala  Val Asp Thr Thr Asp  Ile Ser Gly 
    1445                 1450                 1455             


Ala Thr  Val Thr Val Pro Ala  Lys Leu Thr Val Asp  Arg Val Asp 
    1460                 1465                 1470             


Ala Asp  His Pro Ala Thr Phe  Ala Thr Lys Asp Val  Thr Val Thr 
    1475                 1480                 1485             


Leu Gly  Asp Ala Thr Leu Arg  Tyr Gly Val Asp Tyr  Leu Leu Asp 
    1490                 1495                 1500             


Tyr Ala  Gly Asn Thr Ala Val  Gly Lys Ala Thr Val  Thr Val Arg 
    1505                 1510                 1515             


Gly Ile  Asp Lys Tyr Ser Gly  Thr Val Ala Lys Thr  Phe Thr Ile 
    1520                 1525                 1530             


Glu Leu  Lys Asn Ala Pro Ala  Pro Glu Pro Thr Leu  Thr Ser Val 
    1535                 1540                 1545             


Ser Val  Lys Thr Lys Pro Ser  Lys Leu Thr Tyr Val  Val Gly Asp 
    1550                 1555                 1560             


Ala Phe  Asp Pro Ala Gly Leu  Val Leu Gln His Asp  Arg Gln Ala 
    1565                 1570                 1575             


Asp Arg  Pro Pro Gln Pro Leu  Val Gly Glu Gln Ala  Asp Glu Arg 
    1580                 1585                 1590             


Gly Leu  Thr Cys Gly Thr Arg  Cys Asp Arg Val Glu  Gln Leu Arg 
    1595                 1600                 1605             


Lys His  Glu Asn Arg Glu Ala  His Arg Thr Gly Leu  Asp His Leu 
    1610                 1615                 1620             


Glu Phe  Val Gly Ala Ala Asp  Gly Ala Val Gly Glu  Gln Ala Thr 
    1625                 1630                 1635             


Phe Lys  Val His Val His Ala  Asp Gln Gly Asp Gly  Arg His Asp 
    1640                 1645                 1650             


Asp Ala  Asp Glu Arg Asp Ile  Asp Pro His Val Pro  Val Asp His 
    1655                 1660                 1665             


Ala Val  Gly Glu Leu Ala Arg  Ala Ala Cys His His  Val Ile Gly 
    1670                 1675                 1680             


Leu Arg  Val Asp Thr His Arg  Leu Lys Ala Ser Gly  Phe Gln Ile 
    1685                 1690                 1695             


Pro Ala  Asp Asp Met Ala Glu  Ile Asp Arg Ile Thr  Gly Phe His 
    1700                 1705                 1710             


Arg Phe  Glu Arg His Val Gly  
    1715                 1720 


<210>  23
<211>  30
<212>  PRT
<213>  Bifidobacterium bifidum

<400>  23

Val Arg Ser Lys Lys Leu Trp Ile Ser Leu Leu Phe Ala Leu Ala Leu 
1               5                   10                  15      


Ile Phe Thr Met Ala Phe Gly Ser Thr Ser Ser Ala Gln Ala 
            20                  25                  30  


