                         SEQUENCE LISTING

<110>  WILLIAM MARSH RICE UNIVERSITY
 
<120>  BIOSYNTHESIS OF PRODUCTS FROM 1-CARBON COMPOUNDS

<130>  RICE:2015-017-02WO

<150>  62/069,850
<151>  2014-10-29

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  578
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Asp Ser Asn Phe Ala Glu Arg Ser Glu Glu Gln Val Ser Gly 
1               5                   10                  15      


Ala Lys Val Ile Ala Gln Ala Leu Lys Thr Gln Asp Val Glu Tyr Ile 
            20                  25                  30          


Phe Gly Ile Val Gly Ile Pro Val Thr Glu Ile Ala Ile Ala Ala Gln 
        35                  40                  45              


Gln Leu Gly Ile Lys Tyr Ile Gly Met Arg Asn Glu Gln Ala Ala Cys 
    50                  55                  60                  


Tyr Ala Ala Ser Ala Ile Gly Tyr Leu Thr Ser Arg Pro Gly Val Cys 
65                  70                  75                  80  


Leu Val Val Ser Gly Pro Gly Leu Ile His Ala Leu Gly Gly Met Ala 
                85                  90                  95      


Asn Ala Asn Met Asn Cys Trp Pro Leu Leu Val Ile Gly Gly Ser Ser 
            100                 105                 110         


Glu Arg Asn Gln Glu Thr Met Gly Ala Phe Gln Glu Phe Pro Gln Val 
        115                 120                 125             


Glu Ala Cys Arg Leu Tyr Thr Lys Phe Ser Ala Arg Pro Ser Ser Ile 
    130                 135                 140                 


Glu Ala Ile Pro Phe Val Ile Glu Lys Ala Val Arg Ser Ser Ile Tyr 
145                 150                 155                 160 


Gly Arg Pro Gly Ala Cys Tyr Val Asp Ile Pro Ala Asp Phe Val Asn 
                165                 170                 175     


Leu Gln Val Asn Val Asn Ser Ile Lys Tyr Met Glu Arg Cys Met Ser 
            180                 185                 190         


Pro Pro Ile Ser Met Ala Glu Thr Ser Ala Val Cys Thr Ala Ala Ser 
        195                 200                 205             


Val Ile Arg Asn Ala Lys Gln Pro Leu Leu Ile Ile Gly Lys Gly Ala 
    210                 215                 220                 


Ala Tyr Ala His Ala Glu Glu Ser Ile Lys Lys Leu Val Glu Gln Tyr 
225                 230                 235                 240 


Lys Leu Pro Phe Leu Pro Thr Pro Met Gly Lys Gly Val Val Pro Asp 
                245                 250                 255     


Asn His Pro Tyr Cys Val Gly Ala Ala Arg Ser Arg Ala Leu Gln Phe 
            260                 265                 270         


Ala Asp Val Ile Val Leu Phe Gly Ala Arg Leu Asn Trp Ile Leu His 
        275                 280                 285             


Phe Gly Leu Pro Pro Arg Tyr Gln Pro Asp Val Lys Phe Ile Gln Val 
    290                 295                 300                 


Asp Ile Cys Ala Glu Glu Leu Gly Asn Asn Val Lys Pro Ala Val Thr 
305                 310                 315                 320 


Leu Leu Gly Asn Ile His Ala Val Thr Lys Gln Leu Leu Glu Glu Leu 
                325                 330                 335     


Asp Lys Thr Pro Trp Gln Tyr Pro Pro Glu Ser Lys Trp Trp Lys Thr 
            340                 345                 350         


Leu Arg Glu Lys Met Lys Ser Asn Glu Ala Ala Ser Lys Glu Leu Ala 
        355                 360                 365             


Ser Lys Lys Ser Leu Pro Met Asn Tyr Tyr Thr Val Phe Tyr His Val 
    370                 375                 380                 


Gln Glu Gln Leu Pro Arg Asp Cys Phe Val Val Ser Glu Gly Ala Asn 
385                 390                 395                 400 


Thr Met Asp Ile Gly Arg Thr Val Leu Gln Asn Tyr Leu Pro Arg His 
                405                 410                 415     


Arg Leu Asp Ala Gly Thr Phe Gly Thr Met Gly Val Gly Leu Gly Phe 
            420                 425                 430         


Ala Ile Ala Ala Ala Val Val Ala Lys Asp Arg Ser Pro Gly Gln Trp 
        435                 440                 445             


Ile Ile Cys Val Glu Gly Asp Ser Ala Phe Gly Phe Ser Gly Met Glu 
    450                 455                 460                 


Val Glu Thr Ile Cys Arg Tyr Asn Leu Pro Ile Ile Leu Leu Val Val 
465                 470                 475                 480 


Asn Asn Asn Gly Ile Tyr Gln Gly Phe Asp Thr Asp Thr Trp Lys Glu 
                485                 490                 495     


Met Leu Lys Phe Gln Asp Ala Thr Ala Val Val Pro Pro Met Cys Leu 
            500                 505                 510         


Leu Pro Asn Ser His Tyr Glu Gln Val Met Thr Ala Phe Gly Gly Lys 
        515                 520                 525             


Gly Tyr Phe Val Gln Thr Pro Glu Glu Leu Gln Lys Ser Leu Arg Gln 
    530                 535                 540                 


Ser Leu Ala Asp Thr Thr Lys Pro Ser Leu Ile Asn Ile Met Ile Glu 
545                 550                 555                 560 


Pro Gln Ala Thr Arg Lys Ala Gln Asp Phe His Trp Leu Thr Arg Ser 
                565                 570                 575     


Asn Met 
        


<210>  2
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Asp Ser Asn Phe Ala Glu Arg Ser Glu Glu Gln Val Ser Gly 
1               5                   10                  15      


Ala Lys Val Ile Ala Gln Ala Leu Lys Thr Gln Asp Val Glu Tyr Ile 
            20                  25                  30          


Phe Gly Ile Val Gly Ile Pro Val Thr Glu Ile Ala Ile Ala Ala Gln 
        35                  40                  45              


Gln Leu Gly Ile Lys Tyr Ile Gly Met Arg Asn Glu Gln Ala Ala Cys 
    50                  55                  60                  


Tyr Ala Ala Ser Ala Ile Gly Tyr Leu Thr Ser Arg Pro Leu Leu Val 
65                  70                  75                  80  


Ile Gly Gly Ser Ser Glu Arg Asn Gln Glu Thr Met Gly Ala Phe Gln 
                85                  90                  95      


Glu Phe Pro Gln Val Glu Ala Cys Arg Leu Tyr Thr Lys Phe Ser Ala 
            100                 105                 110         


Arg Pro Ser Ser Ile Glu Ala Ile Pro Phe Val Ile Glu Lys Ala Val 
        115                 120                 125             


Arg Ser Ser Ile Tyr Gly Arg Pro Gly Ala Cys Tyr Val Asp Ile Pro 
    130                 135                 140                 


Ala Asp Phe Val Asn Leu Gln Val Asn Val Asn Ser Ile Lys Tyr Met 
145                 150                 155                 160 


Glu Arg Cys Met Ser Pro Pro Ile Ser Met Ala Glu Thr Ser Ala Val 
                165                 170                 175     


Cys Thr Ala Ala Ser Val Ile Arg Asn Ala Lys Gln Pro Leu Leu Ile 
            180                 185                 190         


Ile Gly Lys Gly Ala Ala Tyr Ala His Ala Glu Glu Ser Ile Lys Lys 
        195                 200                 205             


Leu Val Glu Gln Tyr Lys Leu Pro Phe Leu Pro Thr Pro Met Gly Lys 
    210                 215                 220                 


Gly Val Val Pro Asp Asn His Pro Tyr Cys Val Gly Ala Ala Arg Ser 
225                 230                 235                 240 


Arg Ala Leu Gln Phe Ala Asp Val Ile Val Leu Phe Gly Ala Arg Leu 
                245                 250                 255     


Asn Trp Ile Leu His Phe Gly Leu Pro Pro Arg Tyr Gln Pro Asp Val 
            260                 265                 270         


Lys Phe Ile Gln Val Asp Ile Cys Ala Glu Glu Leu Gly Asn Asn Val 
        275                 280                 285             


Lys Pro Ala Val Thr Leu Leu Gly Asn Ile His Ala Val Thr Lys Gln 
    290                 295                 300                 


Leu Leu Glu Glu Leu Asp Lys Thr Pro Trp Gln Tyr Pro Pro Glu Ser 
305                 310                 315                 320 


Lys Trp Trp Lys Thr Leu Arg Glu Lys Met Lys Ser Asn Glu Ala Ala 
                325                 330                 335     


Ser Lys Glu Leu Ala Ser Lys Lys Ser Leu Pro Met Asn Tyr Tyr Thr 
            340                 345                 350         


Val Phe Tyr His Val Gln Glu Gln Leu Pro Arg Asp Cys Phe Val Val 
        355                 360                 365             


Ser Glu Gly Ala Asn Thr Met Asp Ile Gly Arg Thr Val Leu Gln Asn 
    370                 375                 380                 


Tyr Leu Pro Arg His Arg Leu Asp Ala Gly Thr Phe Gly Thr Met Gly 
385                 390                 395                 400 


Val Gly Leu Gly Phe Ala Ile Ala Ala Ala Val Val Ala Lys Asp Arg 
                405                 410                 415     


Ser Pro Gly Gln Trp Ile Ile Cys Val Glu Gly Asp Ser Ala Phe Gly 
            420                 425                 430         


Phe Ser Gly Met Glu Val Glu Thr Ile Cys Arg Tyr Asn Leu Pro Ile 
        435                 440                 445             


Ile Leu Leu Val Val Asn Asn Asn Gly Ile Tyr Gln Gly Phe Asp Thr 
    450                 455                 460                 


Asp Thr Trp Lys Glu Met Leu Lys Phe Gln Asp Ala Thr Ala Val Val 
465                 470                 475                 480 


Pro Pro Met Cys Leu Leu Pro Asn Ser His Tyr Glu Gln Val Met Thr 
                485                 490                 495     


Ala Phe Gly Gly Lys Gly Tyr Phe Val Gln Thr Pro Glu Glu Leu Gln 
            500                 505                 510         


Lys Ser Leu Arg Gln Ser Leu Ala Asp Thr Thr Lys Pro Ser Leu Ile 
        515                 520                 525             


Asn Ile Met Ile Glu Pro Gln Ala Thr Arg Lys Ala Gln Asp Phe His 
    530                 535                 540                 


Trp Leu Thr Arg Ser Asn Met 
545                 550     


<210>  3
<211>  496
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Pro Asp Ser Asn Phe Ala Glu Arg Ser Glu Glu Gln Val Ser Gly 
1               5                   10                  15      


Ala Lys Val Ile Ala Gln Ala Leu Lys Thr Gln Asp Val Glu Tyr Ile 
            20                  25                  30          


Phe Gly Ile Val Gly Ile Pro Val Thr Glu Ile Ala Ile Ala Ala Gln 
        35                  40                  45              


Gln Leu Gly Ile Lys Tyr Ile Gly Met Arg Asn Glu Gln Ala Ala Cys 
    50                  55                  60                  


Tyr Ala Ala Ser Ala Ile Gly Tyr Leu Thr Ser Arg Pro Gly Val Cys 
65                  70                  75                  80  


Leu Val Val Ser Gly Pro Gly Leu Ile His Ala Leu Gly Gly Met Ala 
                85                  90                  95      


Asn Ala Asn Met Asn Cys Trp Tyr Met Glu Arg Cys Met Ser Pro Pro 
            100                 105                 110         


Ile Ser Met Ala Glu Thr Ser Ala Val Cys Thr Ala Ala Ser Val Ile 
        115                 120                 125             


Arg Asn Ala Lys Gln Pro Leu Leu Ile Ile Gly Lys Gly Ala Ala Tyr 
    130                 135                 140                 


Ala His Ala Glu Glu Ser Ile Lys Lys Leu Val Glu Gln Tyr Lys Leu 
145                 150                 155                 160 


Pro Phe Leu Pro Thr Pro Met Gly Lys Gly Val Val Pro Asp Asn His 
                165                 170                 175     


Pro Tyr Cys Val Gly Ala Ala Arg Ser Arg Ala Leu Gln Phe Ala Asp 
            180                 185                 190         


Val Ile Val Leu Phe Gly Ala Arg Leu Asn Trp Ile Leu His Phe Gly 
        195                 200                 205             


Leu Pro Pro Arg Tyr Gln Pro Asp Val Lys Phe Ile Gln Val Asp Ile 
    210                 215                 220                 


Cys Ala Glu Glu Leu Gly Asn Asn Val Lys Pro Ala Val Thr Leu Leu 
225                 230                 235                 240 


Gly Asn Ile His Ala Val Thr Lys Gln Leu Leu Glu Glu Leu Asp Lys 
                245                 250                 255     


Thr Pro Trp Gln Tyr Pro Pro Glu Ser Lys Trp Trp Lys Thr Leu Arg 
            260                 265                 270         


Glu Lys Met Lys Ser Asn Glu Ala Ala Ser Lys Glu Leu Ala Ser Lys 
        275                 280                 285             


Lys Ser Leu Pro Met Asn Tyr Tyr Thr Val Phe Tyr His Val Gln Glu 
    290                 295                 300                 


Gln Leu Pro Arg Asp Cys Phe Val Val Ser Glu Gly Ala Asn Thr Met 
305                 310                 315                 320 


Asp Ile Gly Arg Thr Val Leu Gln Asn Tyr Leu Pro Arg His Arg Leu 
                325                 330                 335     


Asp Ala Gly Thr Phe Gly Thr Met Gly Val Gly Leu Gly Phe Ala Ile 
            340                 345                 350         


Ala Ala Ala Val Val Ala Lys Asp Arg Ser Pro Gly Gln Trp Ile Ile 
        355                 360                 365             


Cys Val Glu Gly Asp Ser Ala Phe Gly Phe Ser Gly Met Glu Val Glu 
    370                 375                 380                 


Thr Ile Cys Arg Tyr Asn Leu Pro Ile Ile Leu Leu Val Val Asn Asn 
385                 390                 395                 400 


Asn Gly Ile Tyr Gln Gly Phe Asp Thr Asp Thr Trp Lys Glu Met Leu 
                405                 410                 415     


Lys Phe Gln Asp Ala Thr Ala Val Val Pro Pro Met Cys Leu Leu Pro 
            420                 425                 430         


Asn Ser His Tyr Glu Gln Val Met Thr Ala Phe Gly Gly Lys Gly Tyr 
        435                 440                 445             


Phe Val Gln Thr Pro Glu Glu Leu Gln Lys Ser Leu Arg Gln Ser Leu 
    450                 455                 460                 


Ala Asp Thr Thr Lys Pro Ser Leu Ile Asn Ile Met Ile Glu Pro Gln 
465                 470                 475                 480 


Ala Thr Arg Lys Ala Gln Asp Phe His Trp Leu Thr Arg Ser Asn Met 
                485                 490                 495     


<210>  4
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Pro Asp Ser Asn Phe Ala Glu Arg Ser Glu Glu Gln Val Ser Gly 
1               5                   10                  15      


Ala Lys Val Ile Ala Gln Ala Leu Lys Thr Gln Asp Val Glu Tyr Ile 
            20                  25                  30          


Phe Gly Ile Val Gly Ile Pro Val Thr Glu Ile Ala Ile Ala Ala Gln 
        35                  40                  45              


Gln Leu Gly Ile Lys Tyr Ile Gly Met Arg Asn Glu Gln Ala Ala Cys 
    50                  55                  60                  


Tyr Ala Ala Ser Ala Ile Gly Tyr Leu Thr Ser Arg Pro Gly Val Cys 
65                  70                  75                  80  


Leu Val Val Ser Gly Pro Gly Leu Ile His Ala Leu Gly Gly Met Ala 
                85                  90                  95      


Asn Ala Asn Met Asn Cys Trp Pro Leu Leu Val Ile Gly Gly Ser Ser 
            100                 105                 110         


Glu Arg Asn Gln Glu Thr Met Gly Ala Phe Gln Glu Phe Pro Gln Ala 
        115                 120                 125             


Val Arg Ser Ser Ile Tyr Gly Arg Pro Gly Ala Cys Tyr Val Asp Ile 
    130                 135                 140                 


Pro Ala Asp Phe Val Asn Leu Gln Val Asn Val Asn Ser Ile Lys Tyr 
145                 150                 155                 160 


Met Glu Arg Cys Met Ser Pro Pro Ile Ser Met Ala Glu Thr Ser Ala 
                165                 170                 175     


Val Cys Thr Ala Ala Ser Val Ile Arg Asn Ala Lys Gln Pro Leu Leu 
            180                 185                 190         


Ile Ile Gly Lys Gly Ala Ala Tyr Ala His Ala Glu Glu Ser Ile Lys 
        195                 200                 205             


Lys Leu Val Glu Gln Tyr Lys Leu Pro Phe Leu Pro Thr Pro Met Gly 
    210                 215                 220                 


Lys Gly Val Val Pro Asp Asn His Pro Tyr Cys Val Gly Ala Ala Arg 
225                 230                 235                 240 


Ser Arg Ala Leu Gln Phe Ala Asp Val Ile Val Leu Phe Gly Ala Arg 
                245                 250                 255     


Leu Asn Trp Ile Leu His Phe Gly Leu Pro Pro Arg Tyr Gln Pro Asp 
            260                 265                 270         


Val Lys Phe Ile Gln Val Asp Ile Cys Ala Glu Glu Leu Gly Asn Asn 
        275                 280                 285             


Val Lys Pro Ala Val Thr Leu Leu Gly Asn Ile His Ala Val Thr Lys 
    290                 295                 300                 


Gln Glu Leu Ala Ser Lys Lys Ser Leu Pro Met Asn Tyr Tyr Thr Val 
305                 310                 315                 320 


Phe Tyr His Val Gln Glu Gln Leu Pro Arg Asp Cys Phe Val Val Ser 
                325                 330                 335     


Glu Gly Ala Asn Thr Met Asp Ile Gly Arg Thr Val Leu Gln Asn Tyr 
            340                 345                 350         


Leu Pro Arg His Arg Leu Asp Ala Gly Thr Phe Gly Thr Met Gly Val 
        355                 360                 365             


Gly Leu Gly Phe Ala Ile Ala Ala Ala Val Val Ala Lys Asp Arg Ser 
    370                 375                 380                 


Pro Gly Gln Trp Ile Ile Cys Val Glu Gly Asp Ser Ala Phe Gly Phe 
385                 390                 395                 400 


Ser Gly Met Glu Val Glu Thr Ile Cys Arg Tyr Asn Leu Pro Ile Ile 
                405                 410                 415     


Leu Leu Val Val Asn Asn Asn Gly Ile Tyr Gln Gly Phe Asp Thr Asp 
            420                 425                 430         


Thr Trp Lys Glu Met Leu Lys Phe Gln Asp Ala Thr Ala Val Val Pro 
        435                 440                 445             


Pro Met Cys Leu Leu Pro Asn Ser His Tyr Glu Gln Val Met Thr Ala 
    450                 455                 460                 


Phe Gly Gly Lys Gly Tyr Phe Val Gln Thr Pro Glu Glu Leu Gln Lys 
465                 470                 475                 480 


Ser Leu Arg Gln Ser Leu Ala Asp Thr Thr Lys Pro Ser Leu Ile Asn 
                485                 490                 495     


Ile Met Ile Glu Pro Gln Ala Thr Arg Lys Ala Gln Asp Phe His Trp 
            500                 505                 510         


Leu Thr Arg Ser Asn Met 
        515             


