                         SEQUENCE LISTING

<110>  Scripps Research Institute
       Schimmel, Paul
       Mathew, Sajish
 
<120>  COMPOSITIONS AND METHODS COMPRISING TYROSYL-TRNA SYNTHETASES AND 
       RESVERATROL COMPOUNDS

<130>  ATYR-122/01WO

<150>  US 62/072,561
<151>  2014-10-30

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  528
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg 
1               5                   10                  15      


Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys 
            20                  25                  30          


Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro 
        35                  40                  45              


His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys 
    50                  55                  60                  


Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu 
65                  70                  75                  80  


Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr 
                85                  90                  95      


Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu 
            100                 105                 110         


Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu 
        115                 120                 125             


Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp 
    130                 135                 140                 


Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu 
145                 150                 155                 160 


Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr 
                165                 170                 175     


Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe 
            180                 185                 190         


Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val 
        195                 200                 205             


His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser 
    210                 215                 220                 


Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp 
225                 230                 235                 240 


Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu 
                245                 250                 255     


Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys 
            260                 265                 270         


Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr 
        275                 280                 285             


Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val 
    290                 295                 300                 


His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu 
305                 310                 315                 320 


Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu 
                325                 330                 335     


Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys 
            340                 345                 350         


Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu 
        355                 360                 365             


Asp Ile Arg Val Gly Lys Ile Ile Thr Val Glu Lys His Pro Asp Ala 
    370                 375                 380                 


Asp Ser Leu Tyr Val Glu Lys Ile Asp Val Gly Glu Ala Glu Pro Arg 
385                 390                 395                 400 


Thr Val Val Ser Gly Leu Val Gln Phe Val Pro Lys Glu Glu Leu Gln 
                405                 410                 415     


Asp Arg Leu Val Val Val Leu Cys Asn Leu Lys Pro Gln Lys Met Arg 
            420                 425                 430         


Gly Val Glu Ser Gln Gly Met Leu Leu Cys Ala Ser Ile Glu Gly Ile 
        435                 440                 445             


Asn Arg Gln Val Glu Pro Leu Asp Pro Pro Ala Gly Ser Ala Pro Gly 
    450                 455                 460                 


Glu His Val Phe Val Lys Gly Tyr Glu Lys Gly Gln Pro Asp Glu Glu 
465                 470                 475                 480 


Leu Lys Pro Lys Lys Lys Val Phe Glu Lys Leu Gln Ala Asp Phe Lys 
                485                 490                 495     


Ile Ser Glu Glu Cys Ile Ala Gln Trp Lys Gln Thr Asn Phe Met Thr 
            500                 505                 510         


Lys Leu Gly Ser Ile Ser Cys Lys Ser Leu Lys Gly Gly Asn Ile Ser 
        515                 520                 525             


<210>  2
<211>  528
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (341)..(341)
<223>  Xaa may be Ala, Gly, Phe, Val, Leu, Ile, Met or Pro

<400>  2

Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg 
1               5                   10                  15      


Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys 
            20                  25                  30          


Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro 
        35                  40                  45              


His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys 
    50                  55                  60                  


Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu 
65                  70                  75                  80  


Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr 
                85                  90                  95      


Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu 
            100                 105                 110         


Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu 
        115                 120                 125             


Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp 
    130                 135                 140                 


Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu 
145                 150                 155                 160 


Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr 
                165                 170                 175     


Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe 
            180                 185                 190         


Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val 
        195                 200                 205             


His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser 
    210                 215                 220                 


Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp 
225                 230                 235                 240 


Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu 
                245                 250                 255     


Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys 
            260                 265                 270         


Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr 
        275                 280                 285             


Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val 
    290                 295                 300                 


His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu 
305                 310                 315                 320 


Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu 
                325                 330                 335     


Ala Ser Ala Ala Xaa Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys 
            340                 345                 350         


Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu 
        355                 360                 365             


Asp Ile Arg Val Gly Lys Ile Ile Thr Val Glu Lys His Pro Asp Ala 
    370                 375                 380                 


Asp Ser Leu Tyr Val Glu Lys Ile Asp Val Gly Glu Ala Glu Pro Arg 
385                 390                 395                 400 


Thr Val Val Ser Gly Leu Val Gln Phe Val Pro Lys Glu Glu Leu Gln 
                405                 410                 415     


Asp Arg Leu Val Val Val Leu Cys Asn Leu Lys Pro Gln Lys Met Arg 
            420                 425                 430         


Gly Val Glu Ser Gln Gly Met Leu Leu Cys Ala Ser Ile Glu Gly Ile 
        435                 440                 445             


Asn Arg Gln Val Glu Pro Leu Asp Pro Pro Ala Gly Ser Ala Pro Gly 
    450                 455                 460                 


Glu His Val Phe Val Lys Gly Tyr Glu Lys Gly Gln Pro Asp Glu Glu 
465                 470                 475                 480 


Leu Lys Pro Lys Lys Lys Val Phe Glu Lys Leu Gln Ala Asp Phe Lys 
                485                 490                 495     


Ile Ser Glu Glu Cys Ile Ala Gln Trp Lys Gln Thr Asn Phe Met Thr 
            500                 505                 510         


Lys Leu Gly Ser Ile Ser Cys Lys Ser Leu Lys Gly Gly Asn Ile Ser 
        515                 520                 525             


<210>  3
<211>  528
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg 
1               5                   10                  15      


Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys 
            20                  25                  30          


Glu Arg Glu Leu Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro 
        35                  40                  45              


His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys 
    50                  55                  60                  


Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu 
65                  70                  75                  80  


Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Val Ser Tyr 
                85                  90                  95      


Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu 
            100                 105                 110         


Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu 
        115                 120                 125             


Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp 
    130                 135                 140                 


Ser Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu 
145                 150                 155                 160 


Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr 
                165                 170                 175     


Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe 
            180                 185                 190         


Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val 
        195                 200                 205             


His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser 
    210                 215                 220                 


Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp 
225                 230                 235                 240 


Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu 
                245                 250                 255     


Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys 
            260                 265                 270         


Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr 
        275                 280                 285             


Tyr Thr Ala Tyr Val Asp Leu Glu Lys Asp Phe Ala Ala Glu Val Val 
    290                 295                 300                 


His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu 
305                 310                 315                 320 


Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu 
                325                 330                 335     


Ala Ser Ala Ala Ala Pro Asp Pro Ser Lys Gln Lys Pro Met Ala Lys 
            340                 345                 350         


Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu 
        355                 360                 365             


Asp Ile Arg Val Gly Lys Ile Ile Thr Val Glu Lys His Pro Asp Ala 
    370                 375                 380                 


Asp Ser Leu Tyr Val Glu Lys Ile Asp Val Gly Glu Ala Glu Pro Arg 
385                 390                 395                 400 


Thr Val Val Ser Gly Leu Val Gln Phe Val Pro Lys Glu Glu Leu Gln 
                405                 410                 415     


Asp Arg Leu Val Val Val Leu Cys Asn Leu Lys Pro Gln Lys Met Arg 
            420                 425                 430         


Gly Val Glu Ser Gln Gly Met Leu Leu Cys Ala Ser Ile Glu Gly Ile 
        435                 440                 445             


Asn Arg Gln Val Glu Pro Leu Asp Pro Pro Ala Gly Ser Ala Pro Gly 
    450                 455                 460                 


Glu His Val Phe Val Lys Gly Tyr Glu Lys Gly Gln Pro Asp Glu Glu 
465                 470                 475                 480 


Leu Lys Pro Lys Lys Lys Val Phe Glu Lys Leu Gln Ala Asp Phe Lys 
                485                 490                 495     


Ile Ser Glu Glu Cys Ile Ala Gln Trp Lys Gln Thr Asn Phe Met Thr 
            500                 505                 510         


Lys Leu Gly Ser Ile Ser Cys Lys Ser Leu Lys Gly Gly Asn Ile Ser 
        515                 520                 525             


<210>  4
<211>  528
<212>  PRT
<213>  Bos taurus

<400>  4

Met Gly Asp Ser Leu Ser Pro Glu Glu Lys Leu Ser Leu Ile Thr Arg 
1               5                   10                  15      


Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys 
            20                  25                  30          


Glu Arg Glu Leu Lys Val Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro 
        35                  40                  45              


His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys 
    50                  55                  60                  


Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu 
65                  70                  75                  80  


Asp Asn Met Lys Ala Pro Trp Asp Val Leu Glu Leu Arg Thr Ser Tyr 
                85                  90                  95      


Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu 
            100                 105                 110         


Glu Lys Leu Arg Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu 
        115                 120                 125             


Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp 
    130                 135                 140                 


Ala Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu 
145                 150                 155                 160 


Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr 
                165                 170                 175     


Leu Lys Val Asp Ala Gln Phe Gly Gly Val Asp Gln Arg Lys Ile Phe 
            180                 185                 190         


Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Ile 
        195                 200                 205             


His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser 
    210                 215                 220                 


Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp 
225                 230                 235                 240 


Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu 
                245                 250                 255     


Asn Asn Gly Val Leu Ala Phe Ile Arg His Val Leu Phe Pro Leu Lys 
            260                 265                 270         


Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr 
        275                 280                 285             


Tyr Thr Ala Tyr Leu Asp Leu Glu Lys Asp Phe Ala Asp Glu Val Val 
    290                 295                 300                 


His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu 
305                 310                 315                 320 


Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu 
                325                 330                 335     


Ser Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Ala Val Lys 
            340                 345                 350         


Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu 
        355                 360                 365             


Asp Ile Arg Val Gly Lys Val Ile Ser Val Asp Lys His Pro Asp Ala 
    370                 375                 380                 


Asp Ser Leu Tyr Val Glu Lys Ile Asp Val Gly Glu Ala Glu Pro Arg 
385                 390                 395                 400 


Thr Val Val Ser Gly Leu Val Gln Phe Val Pro Lys Glu Glu Leu Gln 
                405                 410                 415     


Asp Arg Leu Val Val Val Leu Cys Asn Leu Lys Pro Gln Lys Met Arg 
            420                 425                 430         


Gly Val Lys Ser Gln Gly Met Leu Leu Cys Ala Ser Val Glu Gly Val 
        435                 440                 445             


Asn Arg Lys Val Glu Pro Leu Asp Pro Pro Ala Gly Ser Ala Pro Gly 
    450                 455                 460                 


Glu Arg Val Phe Val Lys Gly Tyr Glu Lys Gly Gln Pro Asp Glu Glu 
465                 470                 475                 480 


Leu Lys Pro Lys Lys Lys Val Phe Glu Lys Leu Gln Ala Asp Phe Lys 
                485                 490                 495     


Ile Ser Asp Glu Tyr Ile Ala Gln Trp Lys Gln Thr Asn Phe Met Thr 
            500                 505                 510         


Lys Met Gly Ser Val Ser Cys Lys Ser Leu Lys Gly Gly Asn Ile Ser 
        515                 520                 525             


<210>  5
<211>  528
<212>  PRT
<213>  Rattus norvegicus

<400>  5

Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg 
1               5                   10                  15      


Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys 
            20                  25                  30          


Glu Arg Glu Leu Lys Val Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro 
        35                  40                  45              


His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys 
    50                  55                  60                  


Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu 
65                  70                  75                  80  


Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Thr Ser Tyr 
                85                  90                  95      


Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu 
            100                 105                 110         


Glu Lys Leu Lys Phe Thr Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu 
        115                 120                 125             


Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Leu Val Thr Gln His Asp 
    130                 135                 140                 


Ala Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu 
145                 150                 155                 160 


Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr 
                165                 170                 175     


Leu Lys Val Asp Ala Gln Phe Gly Gly Ile Asp Gln Arg Lys Ile Phe 
            180                 185                 190         


Thr Phe Ala Glu Lys Tyr Leu Pro Thr Leu Gly Tyr Ser Lys Arg Val 
        195                 200                 205             


His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser 
    210                 215                 220                 


Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp 
225                 230                 235                 240 


Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu 
                245                 250                 255     


Asn Asn Gly Val Leu Ser Phe Val Lys His Val Leu Phe Pro Leu Lys 
            260                 265                 270         


Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr 
        275                 280                 285             


Tyr Thr Ile Tyr Gln Glu Leu Glu Lys Asp Phe Ala Ala Glu Val Val 
    290                 295                 300                 


His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu 
305                 310                 315                 320 


Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu 
                325                 330                 335     


Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Thr Ala Lys 
            340                 345                 350         


Gly Pro Ala Lys Ser Ser Glu Pro Glu Glu Ile Ile Pro Ser Arg Leu 
        355                 360                 365             


Asp Ile Arg Val Gly Lys Ile Leu Ser Val Glu Lys His Pro Asp Ala 
    370                 375                 380                 


Asp Ser Leu Tyr Val Glu Lys Ile Asp Val Gly Glu Ala Glu Pro Arg 
385                 390                 395                 400 


Thr Val Val Ser Gly Leu Val Gln Phe Val Pro Lys Glu Glu Leu Gln 
                405                 410                 415     


Asp Arg Leu Val Val Val Leu Cys Asn Leu Lys Pro Gln Lys Met Arg 
            420                 425                 430         


Gly Val Asp Ser Gln Gly Met Leu Leu Cys Ala Ser Val Glu Gly Val 
        435                 440                 445             


Ser Arg Gln Val Glu Pro Leu Asp Pro Pro Ala Gly Ser Ala Pro Gly 
    450                 455                 460                 


Glu Arg Val Phe Val Gln Gly Tyr Glu Lys Gly Gln Pro Asp Glu Glu 
465                 470                 475                 480 


Leu Lys Pro Lys Lys Lys Val Phe Glu Lys Leu Gln Ala Asp Phe Lys 
                485                 490                 495     


Ile Ser Asp Asp Cys Val Ala Gln Trp Lys Gln Thr Asn Phe Met Thr 
            500                 505                 510         


Lys Leu Gly Phe Val Ser Cys Lys Ser Leu Lys Gly Gly Asn Ile Ser 
        515                 520                 525             


<210>  6
<211>  528
<212>  PRT
<213>  Mus musculus

<400>  6

Met Gly Asp Ala Pro Ser Pro Glu Glu Lys Leu His Leu Ile Thr Arg 
1               5                   10                  15      


Asn Leu Gln Glu Val Leu Gly Glu Glu Lys Leu Lys Glu Ile Leu Lys 
            20                  25                  30          


Glu Arg Glu Leu Lys Val Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro 
        35                  40                  45              


His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys 
    50                  55                  60                  


Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu 
65                  70                  75                  80  


Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Thr Ser Tyr 
                85                  90                  95      


Tyr Glu Asn Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu 
            100                 105                 110         


Glu Lys Leu Lys Phe Ile Lys Gly Thr Asp Tyr Gln Leu Ser Lys Glu 
        115                 120                 125             


Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp 
    130                 135                 140                 


Ala Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu 
145                 150                 155                 160 


Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr 
                165                 170                 175     


Leu Lys Val Asp Ala Gln Phe Gly Gly Val Asp Gln Arg Lys Ile Phe 
            180                 185                 190         


Thr Phe Ala Glu Lys Tyr Leu Pro Ala Leu Gly Tyr Ser Lys Arg Val 
        195                 200                 205             


His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser 
    210                 215                 220                 


Ser Ser Glu Glu Glu Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp 
225                 230                 235                 240 


Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Val Glu 
                245                 250                 255     


Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys 
            260                 265                 270         


Ser Glu Phe Val Ile Leu Arg Asp Glu Lys Trp Gly Gly Asn Lys Thr 
        275                 280                 285             


Tyr Thr Val Tyr Leu Glu Leu Glu Lys Asp Phe Ala Ala Glu Val Val 
    290                 295                 300                 


His Pro Gly Asp Leu Lys Asn Ser Val Glu Val Ala Leu Asn Lys Leu 
305                 310                 315                 320 


Leu Asp Pro Ile Arg Glu Lys Phe Asn Thr Pro Ala Leu Lys Lys Leu 
                325                 330                 335     


Ala Ser Ala Ala Tyr Pro Asp Pro Ser Lys Gln Lys Pro Pro Ala Lys 
            340                 345                 350         


Gly Pro Ala Lys Asn Ser Glu Pro Glu Glu Val Ile Pro Ser Arg Leu 
        355                 360                 365             


Asp Ile Arg Val Gly Lys Ile Leu Ser Val Glu Lys His Pro Asp Ala 
    370                 375                 380                 


Asp Ser Leu Tyr Val Glu Lys Ile Asp Val Gly Glu Ala Glu Pro Arg 
385                 390                 395                 400 


Thr Val Val Ser Gly Leu Val Gln Phe Val Pro Lys Glu Glu Leu Gln 
                405                 410                 415     


Asp Arg Leu Val Val Val Leu Cys Asn Leu Lys Pro Gln Lys Met Arg 
            420                 425                 430         


Gly Val Asp Ser Gln Gly Met Leu Leu Cys Ala Ser Val Glu Gly Val 
        435                 440                 445             


Ser Arg Gln Val Glu Pro Leu Asp Pro Pro Ala Gly Ser Ala Pro Gly 
    450                 455                 460                 


Glu Arg Val Phe Val Gln Gly Tyr Glu Lys Gly Gln Pro Asp Glu Glu 
465                 470                 475                 480 


Leu Lys Pro Lys Lys Lys Val Phe Glu Lys Leu Gln Ala Asp Phe Lys 
                485                 490                 495     


Ile Ser Glu Glu Cys Ile Ala Gln Trp Lys Gln Thr Asn Phe Met Thr 
            500                 505                 510         


Lys Leu Gly Phe Val Ser Cys Lys Ser Leu Lys Gly Gly Asn Ile Ser 
        515                 520                 525             


<210>  7
<211>  527
<212>  PRT
<213>  Gallus gallus

<400>  7

Met Glu Thr Ala Ser Gly Pro Gln Glu Lys Tyr Gln Leu Ile Thr Arg 
1               5                   10                  15      


Asn Leu Gln Glu Val Leu Gly Glu Asp Lys Leu Met Ala Ile Leu Lys 
            20                  25                  30          


Glu Arg Glu Val Lys Ile Tyr Trp Gly Thr Ala Thr Thr Gly Lys Pro 
        35                  40                  45              


His Val Ala Tyr Phe Val Pro Met Ser Lys Ile Ala Asp Phe Leu Lys 
    50                  55                  60                  


Ala Gly Cys Glu Val Thr Ile Leu Phe Ala Asp Leu His Ala Tyr Leu 
65                  70                  75                  80  


Asp Asn Met Lys Ala Pro Trp Glu Leu Leu Glu Leu Arg Thr Arg Tyr 
                85                  90                  95      


Tyr Glu His Val Ile Lys Ala Met Leu Glu Ser Ile Gly Val Pro Leu 
            100                 105                 110         


Glu Lys Leu Lys Phe Ile Arg Gly Thr Asp Tyr Gln Leu Ser Lys Glu 
        115                 120                 125             


Tyr Thr Leu Asp Val Tyr Arg Leu Ser Ser Val Val Thr Gln His Asp 
    130                 135                 140                 


Ala Lys Lys Ala Gly Ala Glu Val Val Lys Gln Val Glu His Pro Leu 
145                 150                 155                 160 


Leu Ser Gly Leu Leu Tyr Pro Gly Leu Gln Ala Leu Asp Glu Glu Tyr 
                165                 170                 175     


Leu Lys Val Asp Ala Gln Phe Gly Gly Val Asp Gln Arg Lys Ile Phe 
            180                 185                 190         


Thr Phe Ala Glu Lys Tyr Leu Pro Ser Leu Gly Tyr Ala Lys Arg Ile 
        195                 200                 205             


His Leu Met Asn Pro Met Val Pro Gly Leu Thr Gly Ser Lys Met Ser 
    210                 215                 220                 


Ser Ser Glu Glu Asp Ser Lys Ile Asp Leu Leu Asp Arg Lys Glu Asp 
225                 230                 235                 240 


Val Lys Lys Lys Leu Lys Lys Ala Phe Cys Glu Pro Gly Asn Ile Glu 
                245                 250                 255     


Asn Asn Gly Val Leu Ser Phe Ile Lys His Val Leu Phe Pro Leu Lys 
            260                 265                 270         


Ser Glu Phe Val Ile Leu Arg Glu Glu Lys Trp Gly Gly Asn Lys Thr 
        275                 280                 285             


Tyr Thr Ala Tyr Glu Thr Leu Glu Lys Asp Phe Ala Glu Gln Val Val 
    290                 295                 300                 


His Pro Gly Asp Leu Lys Asn Ser Val Glu Ala Ala Leu Asn Lys Leu 
305                 310                 315                 320 


Leu Asp Pro Ile Arg Glu Lys Phe Asn Ser Pro Glu Leu Lys Lys Leu 
                325                 330                 335     


Thr Asn Ala Ala Tyr Pro Asn Pro Ser Lys Ala Lys Pro Ala Glu Lys 
            340                 345                 350         


Gly Thr Lys Asn Ser Glu Pro Glu Thr Ile Val Pro Ser Arg Leu Asp 
        355                 360                 365             


Ile Arg Val Gly Lys Val Val Ser Val Glu Lys His Pro Asp Ala Asp 
    370                 375                 380                 


Ser Leu Tyr Val Glu Lys Ile Asp Val Gly Glu Pro Glu Pro Arg Thr 
385                 390                 395                 400 


Val Val Ser Gly Leu Val Gln Phe Val Pro Lys Glu Gln Leu Gln Asp 
                405                 410                 415     


Arg Leu Val Val Leu Leu Cys Asn Leu Lys Pro Gln Lys Met Arg Gly 
            420                 425                 430         


Val Glu Ser Gln Gly Met Val Leu Cys Ala Ser Ser Val Gly Glu Pro 
        435                 440                 445             


Arg Gln Val Glu Pro Leu Asp Pro Pro Ala Glu Cys Cys Ala Gly Glu 
    450                 455                 460                 


Arg Val Tyr Val Glu Gly Tyr Glu Asp Gly Glu Pro Asp Asp Glu Leu 
465                 470                 475                 480 


Lys Pro Lys Lys Lys Val Phe Glu Lys Leu Gln Ala Asp Phe Arg Ile 
                485                 490                 495     


Ser Glu Asp Cys Ile Ala Gln Trp Lys Glu Arg Asn Phe Leu Thr Lys 
            500                 505                 510         


Leu Gly Ser Ile Ser Cys Lys Ser Leu Lys Gly Gly Ser Ile Ser 
        515                 520                 525         


<210>  8
<211>  4
<212>  PRT
<213>  Unknown

<220>
<223>  conserved active site sequence motif

<400>  8

His Ile Gly His 
1               


<210>  9
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  conserved active site sequence motif

<400>  9

Lys Met Ser Lys Ser 
1               5   


<210>  10
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  10
ctagcccaca tgcatgacta ttt                                               23


<210>  11
<211>  26
<212>  DNA
<213>  Homo sapiens

<400>  11
tatatatata tatatatata tatttt                                            26


<210>  12
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  12
tttttttgag actga                                                        15


<210>  13
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  13
tatatatata tatatatata t                                                 21


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Silencer Select Pre-designed siRNA against PARP-1

<400>  14
gcagcuucau aaccgaagat t                                                 21


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Silencer Select Pre-designed siRNA against SIRT1

<400>  15
ggcuugaugg uaaucaguat t                                                 21


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Silencer Select Pre-designed siRNA against TyrRS

<400>  16
ggacuuugcu gcugagguut t                                                 21


