                         SEQUENCE LISTING

<110>  ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.
 
<120>  MULTI-SPECIFIC ANTIBODIES FOR CROSS-NEUTRALIZATION OF MULTIPLE 
       FILOVIRUS GLYCOPROTEINS

<130>  96700/2295

<140>  PCT/US2015/57499
<141>  2015-10-27

<150>  US 62/069,516
<151>  2014-10-28

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  723
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion sequence

<400>  1

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ile Asn Tyr 
            20                  25                  30          


Arg Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Gly Pro Arg Ala Thr Gly Tyr Ser Met Ala Asp Val Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Met 
    130                 135                 140                 


Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr 
145                 150                 155                 160 


Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys 
                165                 170                 175     


Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
            180                 185                 190         


Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
    210                 215                 220                 


Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Ala 
225                 230                 235                 240 


Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Ser 
                245                 250                 255     


Ala Gly Ser Ala Gly Ser Ala Gly Ser Gly Gly Ser Glu Val Gln Leu 
            260                 265                 270         


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
        275                 280                 285             


Ser Cys Ala Ala Ser Gly Phe Ala Phe Asn Tyr Tyr Asp Ile His Trp 
    290                 295                 300                 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Tyr Ile Asn 
305                 310                 315                 320 


Pro Gly Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                325                 330                 335     


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
            340                 345                 350         


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gln Leu 
        355                 360                 365             


Tyr Gly Asn Ser Phe Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
    370                 375                 380                 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
385                 390                 395                 400 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
                405                 410                 415     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            420                 425                 430         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        435                 440                 445             


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
    450                 455                 460                 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
465                 470                 475                 480 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                485                 490                 495     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
            500                 505                 510         


Arg Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        515                 520                 525             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    530                 535                 540                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
545                 550                 555                 560 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                565                 570                 575     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            580                 585                 590         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        595                 600                 605             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    610                 615                 620                 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
625                 630                 635                 640 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                645                 650                 655     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            660                 665                 670         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        675                 680                 685             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    690                 695                 700                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
705                 710                 715                 720 


Pro Gly Lys 
            


<210>  2
<211>  1161
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion sequence

<400>  2
gaagtgcagt tactggaaag cggcggcggc ctggttaaac ctggcggtag tctgcgtctg       60

agttgcgccg ccagcggttt caccctgatc aactaccgca tgaactgggt gcgtcaggca      120

ccgggtaaag gcctggagtg ggtgagcagc attagcagca gcagcagcta tattcactac      180

gccgacagcg tgaaaggccg ctttaccatc agccgcgaca atgccgagaa cagtctgtat      240

ctgcagatga acagcctaag ggcggaagat acagccgtgt actactgtgt gcgcgaaggc      300

cctcgcgcaa ccggctatag catggcagac gtgtttgata tctggggtca gggcaccatg      360

gttacagtta gcagtggtgg tggtggtagt ggtggcggtg gtagcggtgg tggtggcagt      420

gaactggtga tgacccagag cccggatagc ttagccgtga gtctgggcga aagggcgacc      480

attaactgca aaagcagcca gagcgtgctg tacagcagca acaacaagag ctacctggca      540

tggtatcagc aaaaaccggg tcagcctccg aaactgctga tctattgggc aagcacccgc      600

gaaagtggtg ttccggatcg cttcagcggt agtggcagcg gtaccgattt caccctgacc      660

atcagcagtc tgcaggccga ggacgttgca gtgtattact gtcagcagta ctacagcgcc      720

ccgctgacct ttggcggcgg caccaaagtt gaaattaagg gcggcagtgc aggcagcgcc      780

ggtagtgccg gtagtggtgg tagcgaagtt cagctggttg aaagtggcgg cggtctggtg      840

cagcctggtg gtagtctgcg tctgagttgt gccgccagcg gctttgcctt caattactat      900

gacattcatt gggttcgcca ggccccgggt aaaggtctgg aatgggttgc atatatcaac      960

ccgggtggcg gtaacaccta ctatgccgac agcgttaagg gtcgcttcac catcagcgca     1020

gataccagca aaaacaccgc ctacctgcag atgaatagcc tgcgtgcaga agataccgcc     1080

gtttactact gtgcccgcca gctgtacggc aatagcttca tggactattg gggccagggc     1140

accttagtta ccgtgagcag c                                               1161


<210>  3
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion sequence

<400>  3

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ile Asn Tyr 
            20                  25                  30          


Arg Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Gly Pro Arg Ala Thr Gly Tyr Ser Met Ala Asp Val Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Met 
    130                 135                 140                 


Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr 
145                 150                 155                 160 


Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys 
                165                 170                 175     


Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
            180                 185                 190         


Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
    210                 215                 220                 


Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Ala 
225                 230                 235                 240 


Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Ser 
                245                 250                 255     


Ala Gly Ser Ala Gly Ser Ala Gly Ser Gly Gly Ser Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Arg Ala Ser Gln Asp Val Thr Thr Ala Val Ala Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser 
305                 310                 315                 320 


Arg Leu His Asn Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Leu Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
    370                 375                 380                 


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
385                 390                 395                 400 


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
                405                 410                 415     


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
            420                 425                 430         


Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 
        435                 440                 445             


Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
    450                 455                 460                 


Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
465                 470                 475                 480 


Glu Cys Gly Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys 
                485                 490             


<210>  4
<211>  1125
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion sequence

<400>  4
gaagtgcagc tgctggaaag cggtggcggt ctggttaaac ctggcggtag tctgcgcctg       60

agttgcgccg ccagcggttt tacactgatc aactatcgca tgaactgggt gcgtcaggca      120

ccgggtaagg gtctggagtg ggttagcagc attagtagca gcagcagtta cattcactac      180

gccgatagcg tgaaaggccg cttcacaatt agccgcgata acgccgagaa cagcctgtat      240

ctgcagatga acagtttacg cgccgaagat accgccgtgt attattgcgt tcgcgaaggt      300

ccgcgtgcaa ccggctacag catggccgac gttttcgata tttggggtca gggcaccatg      360

gtgacagtta gtagcggtgg tggtggtagt ggtggtggcg gcagcggtgg tggtggtagt      420

gaactggtga tgacccagag cccggatagc ctggcagtga gcctgggtga gcgtgccacc      480

atcaattgca aaagcagcca gagcgtgctg tacagcagca acaacaagag ttacctggcc      540

tggtaccaac agaaaccggg ccagccgccg aaactgctga tttattgggc cagtacccgc      600

gaaagcggcg tgcctgatcg ttttagtggc agcggtagcg gcaccgactt taccctgacc      660

attagcagcc tgcaggccga ggatgtggca gtgtattact gccagcagta ttacagcgcc      720

ccgttaacct ttggcggcgg taccaaagtg gagatcaaag gtggcagtgc aggcagcgcc      780

ggtagtgcag gtagtggtgg tagcgacatc cagatgacac agagtccgag cagcctgagt      840

gccagcgttg gtgaccgtgt gaccattacc tgccgtgcca gccaggatgt taccacagcc      900

gttgcatggt atcagcagaa gccgggtaag gcccctaagt tactgatcta ctgggcaagc      960

cgcctgcata acggtgtgcc gagccgcttt agcggcagtg gtagcggtac cgatttcacc     1020

ctgaccatca gcagtctgca gccggaagat ttcgcaacct actactgtca gcagcattac     1080

agcaccccgc tgacctttgg ccagggcacc aaagtggaaa ttaaa                     1125


<210>  5
<211>  723
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion sequence

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Asn Tyr Tyr 
            20                  25                  30          


Asp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Asn Pro Gly Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Leu Tyr Gly Asn Ser Phe Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Leu Leu Gly Arg Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly Lys Gly Gly Ser Ala Gly Ser Ala Gly Ser 
    450                 455                 460                 


Ala Gly Ser Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
465                 470                 475                 480 


Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                485                 490                 495     


Phe Thr Leu Ile Asn Tyr Arg Met Asn Trp Val Arg Gln Ala Pro Gly 
            500                 505                 510         


Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile 
        515                 520                 525             


His Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    530                 535                 540                 


Ala Glu Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
545                 550                 555                 560 


Thr Ala Val Tyr Tyr Cys Val Arg Glu Gly Pro Arg Ala Thr Gly Tyr 
                565                 570                 575     


Ser Met Ala Asp Val Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr 
            580                 585                 590         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        595                 600                 605             


Gly Ser Glu Leu Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser 
    610                 615                 620                 


Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu 
625                 630                 635                 640 


Tyr Ser Ser Asn Asn Lys Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
                645                 650                 655     


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser 
            660                 665                 670         


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        675                 680                 685             


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
    690                 695                 700                 


Gln Gln Tyr Tyr Ser Ala Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
705                 710                 715                 720 


Glu Ile Lys 
            


<210>  6
<211>  1614
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion sequence

<400>  6
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt cgcgtttaac tattatgata ttcattgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatat attaacccgg gcggtggcaa cacctattat      180

gctgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgccagctg      300

tatggcaaca gctttatgga ctactggggt caaggaaccc tggtcaccgt ctcctcggct      360

agcaccaagg gtccgagcgt gtttcctctg gcacctagca gtaaaagcac cagtggtggt      420

acagcagccc tgggttgcct ggtgaaggat tactttccgg agccggtgac cgttagttgg      480

aatagcggcg ccctgaccag tggcgttcat acatttccgg ccgtgctgca gagtagtggc      540

ctgtacagcc tgagtagcgt tgttaccgtt ccgagcagca gcctgggcac ccagacctat      600

atttgcaatg ttaaccataa accgagcaac acaaaagttg ataaaaaagt tgaaccgaag      660

agctgtgaca aaacccatac atgtgacaaa acacacacct gcccgccttg tccggcacct      720

gagctgctgg gtcgcccgag cgtttttctg tttcctccga aaccgaaaga caccacccag      780

aagagtctga gcctgagtcc tggcaaaggt ggatccgccg gtagcgcagg tagtgcaggt      840

agtggcggca gcgaagttca gctgttagaa agtggcggtg gtctggttaa gccgggcggt      900

agtctgcgcc tgagctgtgc agcaagtggt ttcaccctga tcaattatcg tatgaactgg      960

gtgcgccaag ccccgggtaa aggtctggag tgggttagta gtatcagcag cagcagcagt     1020

tacatccact atgccgatag cgttaagggc cgctttacaa tcagccgcga taatgccgag     1080

aatagcttat acctgcaaat gaacagtcta agggcggaag ataccgccgt ttactactgc     1140

gttcgtgaag gccctcgcgc aacaggctat agcatggcag acgtgttcga catttggggt     1200

cagggcacca tggtgaccgt tagtagcggc ggtggtggta gtggtggtgg cggtagtggt     1260

ggcggtggca gcgaactggt gatgacccag agtccggata gcctggccgt gagcttaggc     1320

gagcgtgcaa ccattaattg taaaagcagt cagagtgttc tgtatagtag caataacaag     1380

agctatctgg cctggtatca gcagaagccg ggccagccgc cgaaactgct gatttactgg     1440

gcaagcaccc gcgaaagtgg cgtgcctgat cgctttagtg gtagcggcag cggcaccgat     1500

tttaccctga ccattagcag tctgcaggcc gaggacgttg ccgtttatta ctgccagcag     1560

tactatagcg caccgctgac atttggcggt ggcaccaagg tggaaattaa ataa           1614


<210>  7
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion sequence

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Thr Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Arg Leu His Asn Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Ser Gly Gly Ser Ala Gly Ser Ala 
    210                 215                 220                 


Gly Ser Ala Gly Ser Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly 
225                 230                 235                 240 


Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                245                 250                 255     


Ser Gly Phe Thr Leu Ile Asn Tyr Arg Met Asn Trp Val Arg Gln Ala 
            260                 265                 270         


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Ser Ser Ser Ser 
        275                 280                 285             


Tyr Ile His Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
    290                 295                 300                 


Asp Asn Ala Glu Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
305                 310                 315                 320 


Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg Glu Gly Pro Arg Ala Thr 
                325                 330                 335     


Gly Tyr Ser Met Ala Asp Val Phe Asp Ile Trp Gly Gln Gly Thr Met 
            340                 345                 350         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        355                 360                 365             


Gly Gly Gly Ser Glu Leu Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
    370                 375                 380                 


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser 
385                 390                 395                 400 


Val Leu Tyr Ser Ser Asn Asn Lys Ser Tyr Leu Ala Trp Tyr Gln Gln 
                405                 410                 415     


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
            420                 425                 430         


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        435                 440                 445             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr 
    450                 455                 460                 


Tyr Cys Gln Gln Tyr Tyr Ser Ala Pro Leu Thr Phe Gly Gly Gly Thr 
465                 470                 475                 480 


Lys Val Glu Ile Lys 
                485 


<210>  8
<211>  1455
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion sequence


<220>
<221>  misc_feature
<222>  (1443)..(1443)
<223>  n is a, c, g, or t

<400>  8
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gggcgagcca ggatgtgacc accgctgtag cctggtatca acagaaacca      120

ggaaaagctc cgaagcttct gatttactgg gcgagccgtc ttcataatgg cgtgccgagc      180

cgctttagcg gcagcggctc cgggacggat ttcactctga ccatcagcag tctgcagccg      240

gaagacttcg caacttatta ctgtcagcaa cattatagca ccccgctgac gttcggacag      300

ggtaccaagg tggagatcaa acgtacggtg gcagcaccga gcgtgtttat ctttccgccg      360

agcgacgaac aactgaaaag tggcacagcc agcgtggtgt gtttactgaa caacttctat      420

cctcgcgagg ccaaggtgca gtggaaagtg gacaatgcac tgcagagtgg caatagccag      480

gagagcgtga ccgaacagga tagcaaagat agcacctata gcctgagtag caccctgacc      540

ctgagcaagg ccgattatga gaagcacaag gtgtatgcat gcgaggttac ccatcagggc      600

ctgagcagcc cggtgaccaa aagctttaac cgtggcgaat gcggtggtag tggtggatcc      660

gccggtagcg caggtagtgc aggtagtggc ggcagcgaag ttcagctgtt agaaagtggc      720

ggtggtctgg ttaagccggg cggtagtctg cgcctgagct gtgcagcaag tggtttcacc      780

ctgatcaatt atcgtatgaa ctgggtgcgc caagccccgg gtaaaggtct ggagtgggtt      840

agtagtatca gcagcagcag cagttacatc cactatgccg atagcgttaa gggccgcttt      900

acaatcagcc gcgataatgc cgagaatagc ttatacctgc aaatgaacag tctaagggcg      960

gaagataccg ccgtttacta ctgcgttcgt gaaggccctc gcgcaacagg ctatagcatg     1020

gcagacgtgt tcgacatttg gggtcagggc accatggtga ccgttagtag cggcggtggt     1080

ggtagtggtg gtggcggtag tggtggcggt ggcagcgaac tggtgatgac ccagagtccg     1140

gatagcctgg ccgtgagctt aggcgagcgt gcaaccatta attgtaaaag cagtcagagt     1200

gttctgtata gtagcaataa caagagctat ctggcctggt atcagcagaa gccgggccag     1260

ccgccgaaac tgctgattta ctgggcaagc acccgcgaaa gtggcgtgcc tgatcgcttt     1320

agtggtagcg gcagcggcac cgattttacc ctgaccatta gcagtctgca ggccgaggac     1380

gttgccgttt attactgcca gcagtactat agcgcaccgc tgacatttgg cggtggcacc     1440

aangtggaaa ttaaa                                                      1455


<210>  9
<211>  723
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion sequence

<400>  9

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ile Asn Tyr 
            20                  25                  30          


Arg Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Gly Pro Arg Ala Thr Gly Tyr Ser Met Ala Asp Val Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Met 
    130                 135                 140                 


Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr 
145                 150                 155                 160 


Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys 
                165                 170                 175     


Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
            180                 185                 190         


Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
    210                 215                 220                 


Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Ala 
225                 230                 235                 240 


Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Ser 
                245                 250                 255     


Ala Gly Ser Ala Gly Ser Ala Gly Ser Gly Gly Ser Glu Val Gln Leu 
            260                 265                 270         


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
        275                 280                 285             


Ser Cys Ala Ala Ser Gly Phe Ala Phe Asn Tyr Tyr Asp Met Phe Trp 
    290                 295                 300                 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Tyr Ile Lys 
305                 310                 315                 320 


Pro Gly Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                325                 330                 335     


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
            340                 345                 350         


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gln Leu 
        355                 360                 365             


Tyr Gly Asn Ser Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
    370                 375                 380                 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
385                 390                 395                 400 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
                405                 410                 415     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            420                 425                 430         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        435                 440                 445             


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
    450                 455                 460                 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
465                 470                 475                 480 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                485                 490                 495     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
            500                 505                 510         


Arg Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        515                 520                 525             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    530                 535                 540                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
545                 550                 555                 560 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                565                 570                 575     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            580                 585                 590         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        595                 600                 605             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    610                 615                 620                 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
625                 630                 635                 640 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                645                 650                 655     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            660                 665                 670         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        675                 680                 685             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    690                 695                 700                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
705                 710                 715                 720 


Pro Gly Lys 
            


<210>  10
<211>  1161
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion sequence

<400>  10
gaagttcagt tactggaaag tggcggcggc ctggttaaac cgggtggtag cctgcgtctg       60

agttgcgcag caagcggctt caccctgatc aactatcgca tgaactgggt gcgccaagca      120

ccgggtaagg gtctggagtg ggtgagcagc atcagcagca gcagcagcta catccactac      180

gcagacagcg ttaaaggccg cttcaccatt agccgcgata acgccgaaaa cagcctgtac      240

ctgcagatga acagtctaag ggcggaggat accgcagtgt actactgcgt tcgtgaaggc      300

ccgcgtgcaa ccggctatag catggccgac gtttttgata tttggggcca gggcaccatg      360

gtgaccgtga gtagtggtgg tggtggcagc ggtggtggcg gtagtggtgg tggtggcagt      420

gaactggtta tgacccagag tccggacagt ctggcagtga gcctgggcga gcgtgcaacc      480

atcaactgta agagcagtca gagcgtgctg tatagtagca acaataaaag ctatctggcc      540

tggtatcagc agaagccggg tcagccgcct aagctgctga tttattgggc cagcacccgc      600

gaaagcggtg ttccggatcg ctttagcggt agcggcagcg gtaccgattt caccctgacc      660

atcagcagcc tgcaggccga agatgtggcc gtgtattatt gccagcagta ctacagcgcc      720

ccgctgacct ttggtggcgg taccaaggtg gaaattaaag gcggcagtgc cggtagtgcc      780

ggtagtgcag gtagcggcgg tagcgaggtt cagctggtgg aaagcggcgg tggtctggtt      840

cagcctggtg gtagcctgcg cctgagctgt gccgcaagcg gtttcgcatt taactactat      900

gacatgttct gggttcgcca ggcaccgggc aaaggtctgg aatgggtggc ctatatcaaa      960

ccgggcggcg gcaacaccta ctacgccgat agcgttaagg gtcgtttcac catcagcgcc     1020

gataccagca aaaacaccgc ctatctgcag atgaatagcc taagggcgga agacaccgca     1080

gtgtattact gcgcacgcca gctgtacggc aacagctttt tcgattactg gggccagggt     1140

accctggtta ccgtgagcag c                                               1161


<210>  11
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion sequence

<400>  11

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ile Asn Tyr 
            20                  25                  30          


Arg Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Gly Pro Arg Ala Thr Gly Tyr Ser Met Ala Asp Val Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Met 
    130                 135                 140                 


Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr 
145                 150                 155                 160 


Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys 
                165                 170                 175     


Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
            180                 185                 190         


Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
    210                 215                 220                 


Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Ala 
225                 230                 235                 240 


Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Ser 
                245                 250                 255     


Ala Gly Ser Ala Gly Ser Ala Gly Ser Gly Gly Ser Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Lys Ala Ser Gln Asp Val Thr Thr Ala Val Ala Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser 
305                 310                 315                 320 


Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Leu Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
    370                 375                 380                 


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
385                 390                 395                 400 


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
                405                 410                 415     


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
            420                 425                 430         


Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 
        435                 440                 445             


Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
    450                 455                 460                 


Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
465                 470                 475                 480 


Glu Cys Gly Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys 
                485                 490             


<210>  12
<211>  1125
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion sequence

<400>  12
gaagttcagt tactggaaag tggcggcggc ctggttaaac cgggtggtag cctgcgtctg       60

agttgcgcag caagcggctt caccctgatc aactatcgca tgaactgggt gcgccaagca      120

ccgggtaagg gtctggagtg ggtgagcagc atcagcagca gcagcagcta catccactac      180

gcagacagcg ttaaaggccg cttcaccatt agccgcgata acgccgaaaa cagcctgtac      240

ctgcagatga acagtctaag ggcggaggat accgcagtgt actactgcgt tcgtgaaggc      300

ccgcgtgcaa ccggctatag catggccgac gtttttgata tttggggcca gggcaccatg      360

gtgaccgtga gtagtggtgg tggtggcagc ggtggtggcg gtagtggtgg tggtggcagt      420

gaactggtta tgacccagag tccggacagt ctggcagtga gcctgggcga gcgtgcaacc      480

atcaactgta agagcagtca gagcgtgctg tatagtagca acaataaaag ctatctggcc      540

tggtatcagc agaagccggg tcagccgcct aagctgctga tttattgggc cagcacccgc      600

gaaagcggtg ttccggatcg ctttagcggt agcggcagcg gtaccgattt caccctgacc      660

atcagcagcc tgcaggccga agatgtggcc gtgtattatt gccagcagta ctacagcgcc      720

ccgctgacct ttggtggcgg taccaaggtg gaaattaaag gcggcagtgc cggtagtgcc      780

ggtagtgcag gtagcggcgg tagcgatatc cagatgaccc agagtccgag tagtctgagc      840

gccagcgttg gtgaccgcgt taccatcacc tgcaaggcca gccaggatgt taccaccgcc      900

gtggcctggt atcaacagaa accgggcaag gccccgaagc tgctgattta ttgggccagt      960

acacgccata caggcgtgcc gagccgtttt agtggcagcg gtagcggtac cgacttcacc     1020

ctgaccatca gtagcctgca accggaggat ttcgccacct actactgcca gcagcactac     1080

agcaccccgc tgacctttgg ccaaggtacc aaggtggaga ttaag                     1125


<210>  13
<211>  723
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion sequence

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Asn Tyr Tyr 
            20                  25                  30          


Asp Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Lys Pro Gly Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Leu Tyr Gly Asn Ser Phe Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Leu Leu Gly Arg Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly Lys Gly Gly Ser Ala Gly Ser Ala Gly Ser 
    450                 455                 460                 


Ala Gly Ser Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
465                 470                 475                 480 


Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                485                 490                 495     


Phe Thr Leu Ile Asn Tyr Arg Met Asn Trp Val Arg Gln Ala Pro Gly 
            500                 505                 510         


Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile 
        515                 520                 525             


His Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    530                 535                 540                 


Ala Glu Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
545                 550                 555                 560 


Thr Ala Val Tyr Tyr Cys Val Arg Glu Gly Pro Arg Ala Thr Gly Tyr 
                565                 570                 575     


Ser Met Ala Asp Val Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr 
            580                 585                 590         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        595                 600                 605             


Gly Ser Glu Leu Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser 
    610                 615                 620                 


Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu 
625                 630                 635                 640 


Tyr Ser Ser Asn Asn Lys Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
                645                 650                 655     


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser 
            660                 665                 670         


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        675                 680                 685             


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
    690                 695                 700                 


Gln Gln Tyr Tyr Ser Ala Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
705                 710                 715                 720 


Glu Ile Lys 
            


<210>  14
<211>  2172
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion sequence

<400>  14
gaagttcaac tggttgagag tggcggtggc ttagttcaac cgggcggtag tttacgcctg       60

agttgtgcag ccagcggttt cgccttcaac tattatgaca tgttttgggt gcgccaggca      120

ccgggtaaag gcctggagtg ggtggcctat atcaaaccgg gcggtggcaa cacctattac      180

gccgatagcg tgaaaggtcg ctttaccatc agcgcagata ccagcaagaa taccgcctac      240

ctgcagatga atagcctgcg tgccgaagac accgccgttt attattgcgc ccgccagctg      300

tacggcaata gctttttcga ttactggggc cagggcaccc tggttaccgt tagcagcgct      360

agcaccaagg gtccgagcgt gtttcctctg gcacctagca gtaaaagcac cagtggtggt      420

acagcagccc tgggttgcct ggtgaaggat tactttccgg agccggtgac cgttagttgg      480

aatagcggcg ccctgaccag tggcgttcat acatttccgg ccgtgctgca gagtagtggc      540

ctgtacagcc tgagtagcgt tgttaccgtt ccgagcagca gcctgggcac ccagacctat      600

atttgcaatg ttaaccataa accgagcaac acaaaagttg ataaaaaagt tgaaccgaag      660

agctgtgaca aaacccatac atgtgacaaa acacacacct gcccgccttg tccggcacct      720

gagctgctgg gtcgcccgag cgtttttctg tttcctccga aaccgaaaga caccctgatg      780

atcagccgca cacctgaggt gacctgtgtt gtggtggatg tgagccacga agatcctgaa      840

gttaagttta actggtatgt ggatggcgtg gaggtgcata atgccaagac aaagccgcgt      900

gaagagcagt acaacagcac ctatcgtgtt gttagtgtgc tgaccgttct gcaccaagat      960

tggctgaacg gcaaggagta taaatgcaag gttagcaata aagccctgcc ggccccgatc     1020

gagaagacca tcagcaaagc caaaggtcag ccgcgtgagc ctcaggtgta tacactgccg     1080

cctagccgtg aggagatgac caagaatcag gttagcctga cctgtctggt gaaaggcttt     1140

tacccgagcg atatcgccgt tgagtgggaa agcaatggtc agcctgagaa caactacaag     1200

accaccccgc ctgttttaga cagtgatggt agctttttct tatacagcaa actgaccgtt     1260

gataagagcc gctggcagca gggcaatgtg tttagctgca gtgttatgca tgaggccctg     1320

cataaccact atacccagaa gagtctgagc ctgagtcctg gcaaaggtgg atccgccggt     1380

agcgcaggta gtgcaggtag tggcggcagc gaagttcagc tgttagaaag tggcggtggt     1440

ctggttaagc cgggcggtag tctgcgcctg agctgtgcag caagtggttt caccctgatc     1500

aattatcgta tgaactgggt gcgccaagcc ccgggtaaag gtctggagtg ggttagtagt     1560

atcagcagca gcagcagtta catccactat gccgatagcg ttaagggccg ctttacaatc     1620

agccgcgata atgccgagaa tagcttatac ctgcaaatga acagtctaag ggcggaagat     1680

accgccgttt actactgcgt tcgtgaaggc cctcgcgcaa caggctatag catggcagac     1740

gtgttcgaca tttggggtca gggcaccatg gtgaccgtta gtagcggcgg tggtggtagt     1800

ggtggtggcg gtagtggtgg cggtggcagc gaactggtga tgacccagag tccggatagc     1860

ctggccgtga gcttaggcga gcgtgcaacc attaattgta aaagcagtca gagtgttctg     1920

tatagtagca ataacaagag ctatctggcc tggtatcagc agaagccggg ccagccgccg     1980

aaactgctga tttactgggc aagcacccgc gaaagtggcg tgcctgatcg ctttagtggt     2040

agcggcagcg gcaccgattt taccctgacc attagcagtc tgcaggccga ggacgttgcc     2100

gtttattact gccagcagta ctatagcgca ccgctgacat ttggcggtgg caccaaggtg     2160

gaaattaaat aa                                                         2172


<210>  15
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion sequence

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Thr Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Ser Gly Gly Ser Ala Gly Ser Ala 
    210                 215                 220                 


Gly Ser Ala Gly Ser Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly 
225                 230                 235                 240 


Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                245                 250                 255     


Ser Gly Phe Thr Leu Ile Asn Tyr Arg Met Asn Trp Val Arg Gln Ala 
            260                 265                 270         


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Ser Ser Ser Ser 
        275                 280                 285             


Tyr Ile His Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
    290                 295                 300                 


Asp Asn Ala Glu Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
305                 310                 315                 320 


Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg Glu Gly Pro Arg Ala Thr 
                325                 330                 335     


Gly Tyr Ser Met Ala Asp Val Phe Asp Ile Trp Gly Gln Gly Thr Met 
            340                 345                 350         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        355                 360                 365             


Gly Gly Gly Ser Glu Leu Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
    370                 375                 380                 


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser 
385                 390                 395                 400 


Val Leu Tyr Ser Ser Asn Asn Lys Ser Tyr Leu Ala Trp Tyr Gln Gln 
                405                 410                 415     


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
            420                 425                 430         


Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        435                 440                 445             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr 
    450                 455                 460                 


Tyr Cys Gln Gln Tyr Tyr Ser Ala Pro Leu Thr Phe Gly Gly Gly Thr 
465                 470                 475                 480 


Lys Val Glu Ile Lys 
                485 


<210>  16
<211>  1458
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion sequence

<400>  16
gacattcaga tgacccaaag tccgagcagc ctgagtgcca gtgttggtga tcgcgtgaca       60

atcacatgca aggccagtca ggacgtgacc accgcagtgg cctggtatca gcagaaaccg      120

ggtaaggccc cgaagctgct gatctattgg gccagtaccc gccacaccgg tgttcctagt      180

cgcttcagtg gcagtggcag cggcacagat ttcaccctga ccatcagcag cctgcaaccg      240

gaagattttg ccacctacta ctgccagcag cactatagca ccccgctgac ctttggccag      300

ggcaccaagg ttgagattaa acgtacggtg gcagcaccga gcgtgtttat ctttccgccg      360

agcgacgaac aactgaaaag tggcacagcc agcgtggtgt gtttactgaa caacttctat      420

cctcgcgagg ccaaggtgca gtggaaagtg gacaatgcac tgcagagtgg caatagccag      480

gagagcgtga ccgaacagga tagcaaagat agcacctata gcctgagtag caccctgacc      540

ctgagcaagg ccgattatga gaagcacaag gtgtatgcat gcgaggttac ccatcagggc      600

ctgagcagcc cggtgaccaa aagctttaac cgtggcgaat gcggtggtag tggtggatcc      660

gccggtagcg caggtagtgc aggtagtggc ggcagcgaag ttcagctgtt agaaagtggc      720

ggtggtctgg ttaagccggg cggtagtctg cgcctgagct gtgcagcaag tggtttcacc      780

ctgatcaatt atcgtatgaa ctgggtgcgc caagccccgg gtaaaggtct ggagtgggtt      840

agtagtatca gcagcagcag cagttacatc cactatgccg atagcgttaa gggccgcttt      900

acaatcagcc gcgataatgc cgagaatagc ttatacctgc aaatgaacag tctaagggcg      960

gaagataccg ccgtttacta ctgcgttcgt gaaggccctc gcgcaacagg ctatagcatg     1020

gcagacgtgt tcgacatttg gggtcagggc accatggtga ccgttagtag cggcggtggt     1080

ggtagtggtg gtggcggtag tggtggcggt ggcagcgaac tggtgatgac ccagagtccg     1140

gatagcctgg ccgtgagctt aggcgagcgt gcaaccatta attgtaaaag cagtcagagt     1200

gttctgtata gtagcaataa caagagctat ctggcctggt atcagcagaa gccgggccag     1260

ccgccgaaac tgctgattta ctgggcaagc acccgcgaaa gtggcgtgcc tgatcgcttt     1320

agtggtagcg gcagcggcac cgattttacc ctgaccatta gcagtctgca ggccgaggac     1380

gttgccgttt attactgcca gcagtactat agcgcaccgc tgacatttgg cggtggcacc     1440

aaggtggaaa ttaaataa                                                   1458


<210>  17
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  17

Gly Gly Ser Ala Gly Ser Ala Gly Ser Ala Gly Ser Gly Gly Ser 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  18

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


