                         SEQUENCE LISTING

<110>  Agency for Science, Technology and Research
 
<120>  Anti-TIM-3 Antibodies

<130>  RIC/FP7157985

<150>  GB 1419094.6
<151>  2014-10-27

<160>  61    

<170>  PatentIn version 3.3

<210>  1
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Light chain variable domain sequence for 
       anti-TIM-3 antibody clone 1B9

<400>  1

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Asn Trp Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Glu Ala Trp Asp Tyr Tyr Val 
                85                  90                  95      


Ala Ala Gly Tyr Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  2
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Light chain variable domain sequence for 
       anti-TIM-3 antibody clone 1H9

<400>  2

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Asn Trp Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Asp Ser Trp Asp Ser Ala Asp 
                85                  90                  95      


Ala Ser Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  3
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Light chain variable domain sequence for 
       anti-TIM-3 antibody clone 1H10

<400>  3

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Asn Trp Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Asp Ser Trp Asp Tyr Asp Tyr 
                85                  90                  95      


Ala Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  4
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Light chain variable domain sequence for 
       anti-TIM-3 antibody clone 2C7

<400>  4

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Asn Trp Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Asp Ser Trp Asp Ser Tyr Leu 
                85                  90                  95      


Ala Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  5
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Light chain variable domain sequence for 
       anti-TIM-3 antibody clone 2F4

<400>  5

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Asn Trp Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Glu Ser Trp Asp Tyr Asp Tyr 
                85                  90                  95      


Ala Ser Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  6
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Light chain variable domain sequence for 
       anti-TIM-3 antibody clone 2G6

<400>  6

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Asn Trp Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Asp Ser Trp Asp Ser Ser Asp 
                85                  90                  95      


Ser Ser Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  7
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Light chain variable domain sequence for 
       anti-TIM-3 antibody clone 1D9

<400>  7

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Asn Trp Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Glu Ala Trp Asp Ser Ala Tyr 
                85                  90                  95      


Ala Ala Gly Ser Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  8
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Light chain variable domain sequence for 
       anti-TIM-3 antibody clone 1F4

<400>  8

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Asn Trp Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Asp Ser Trp Asp Ala Ala Leu 
                85                  90                  95      


Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  9
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Light chain variable domain sequence for 
       anti-TIM-3 antibody clone 2C8

<400>  9

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Asn Trp Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Glu Ser Trp Asp Ala Ala Ala 
                85                  90                  95      


Ala Ala Gly Tyr Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  10
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: LC-CDR1

<400>  10

Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 
1               5                   10              


<210>  11
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: LC-CDR2

<400>  11

Gly Asn Asn Trp Arg Pro Ser 
1               5           


<210>  12
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: LC-CDR3

<400>  12

Glu Ala Trp Asp Tyr Tyr Val Ala Ala Gly Tyr 
1               5                   10      


<210>  13
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: LC-CDR3

<400>  13

Asp Ser Trp Asp Ser Ala Asp Ala Ser Gly Val 
1               5                   10      


<210>  14
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: LC-CDR3

<400>  14

Asp Ser Trp Asp Tyr Asp Tyr Ala Ala Gly Val 
1               5                   10      


<210>  15
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: LC-CDR3

<400>  15

Asp Ser Trp Asp Ser Tyr Leu Ala Ala Gly Val 
1               5                   10      


<210>  16
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: LC-CDR3

<400>  16

Glu Ser Trp Asp Tyr Asp Tyr Ala Ser Gly Val 
1               5                   10      


<210>  17
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: LC-CDR3

<400>  17

Asp Ser Trp Asp Ser Ser Asp Ser Ser Gly Val 
1               5                   10      


<210>  18
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: LC-CDR3

<400>  18

Glu Ala Trp Asp Ser Ala Tyr Ala Ala Gly Ser 
1               5                   10      


<210>  19
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: LC-CDR3

<400>  19

Asp Ser Trp Asp Ala Ala Leu Ser Ala Gly Val 
1               5                   10      


<210>  20
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: LC-CDR3

<400>  20

Glu Ser Trp Asp Ala Ala Ala Ala Ala Gly Tyr 
1               5                   10      


<210>  21
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Heavy chain variable domain sequence for 
       anti-TIM-3 antibody clone 1B9

<400>  21

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Tyr Val Ala Gly Ser Asp Ala Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  22
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Heavy chain variable domain sequence for 
       anti-TIM-3 antibody clone 1H9

<400>  22

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Tyr Val Ala Gly Phe Asp Asp Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  23
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Heavy chain variable domain sequence for 
       anti-TIM-3 antibody clone 1H10

<400>  23

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Tyr Val Ala Gly Phe Asp Ser Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  24
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Heavy chain variable domain sequence for 
       anti-TIM-3 antibody clone 2C7

<400>  24

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Tyr Val Ala Gly Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  25
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Heavy chain variable domain sequence for 
       anti-TIM-3 antibody clone 2F4

<400>  25

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Tyr Val Ala Gly Ser Asp Ala Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  26
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Heavy chain variable domain sequence for 
       anti-TIM-3 antibody clone 2G6

<400>  26

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Tyr Val Ala Gly Phe Asp Ser Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  27
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Heavy chain variable domain sequence for 
       anti-TIM-3 antibody clone 1D9

<400>  27

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Tyr Tyr Ala Gly Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  28
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Heavy chain variable domain sequence for 
       anti-TIM-3 antibody clone 1F4

<400>  28

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Tyr Val Ala Gly Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  29
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Heavy chain variable domain sequence for 
       anti-TIM-3 antibody clone 2C8

<400>  29

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Tyr Val Ala Gly Ser Asp Ala Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  30
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: HC-CDR1

<400>  30

Gly Gly Ser Phe Ser Gly Tyr Tyr Trp Ser 
1               5                   10  


<210>  31
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: HC-CDR2

<400>  31

Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  32
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: HC-CDR3

<400>  32

Gly Tyr Val Ala Gly Ser Asp Ala 
1               5               


<210>  33
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: HC-CDR3

<400>  33

Gly Tyr Val Ala Gly Phe Asp Asp 
1               5               


<210>  34
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: HC-CDR3

<400>  34

Gly Tyr Val Ala Gly Phe Asp Ser 
1               5               


<210>  35
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: HC-CDR3

<400>  35

Gly Tyr Val Ala Gly Tyr Asp Tyr 
1               5               


<210>  36
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: HC-CDR3

<400>  36

Gly Tyr Val Ala Gly Ser Asp Ala 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: HC-CDR3

<400>  37

Gly Tyr Val Ala Gly Phe Asp Ser 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: HC-CDR3

<400>  38

Gly Tyr Tyr Ala Gly Asp Asp Tyr 
1               5               


<210>  39
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: HC-CDR3

<400>  39

Gly Tyr Val Ala Gly Tyr Asp Tyr 
1               5               


<210>  40
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: HC-CDR3

<400>  40

Gly Tyr Val Ala Gly Ser Asp Ala 
1               5               


<210>  41
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: LC-CDR3


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa = Glu or Asp

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa = Ala or Ser

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa = Tyr, Ser or Ala

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa = Tyr, Ala, Asp or Ser

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa = Val, Asp, Tyr, Leu or Ala

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa = Ala or Ser

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa = Ala or Ser

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa = Tyr, Val or Ser

<400>  41

Xaa Xaa Trp Asp Xaa Xaa Xaa Xaa Xaa Gly Xaa 
1               5                   10      


<210>  42
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: HC-CDR3


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa = Val or Tyr

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa = Ser, Phe, Tyr or Asp

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa = Ala, Asp, Ser or Tyr

<400>  42

Gly Tyr Xaa Ala Gly Xaa Asp Xaa 
1               5               


<210>  43
<211>  330
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Nucleotide sequence of light chain variable 
       domain sequence for anti-TIM-3 antibody clone 1B9

<400>  43
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa agtcaccatc     60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta ccagcagctc    120

ccaggaacag cccccaaact cctcatttat ggcaataatt ggcgaccctc agggattcct    180

gaccgcttct ctggctccaa gtctggcacc tcagccaccc tgggcatcac cggacttcag    240

actggggacg aggccgatta ttactgcgaa gcttgggatt attatgttgc tgctgggtat    300

ttcggcggag ggaccaagct gaccgtccta                                     330


<210>  44
<211>  330
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Nucleotide sequence of light chain variable 
       domain sequence for anti-TIM-3 antibody clone 1H9

<400>  44
cagtctgtgc tgacgcagcc gccctcagtg tctgcggccc caggacagaa agtcaccatc     60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta ccagcagctc    120

ccaggaacag cccccaaact cctcatttat ggcaataatt ggcgaccctc agggattcct    180

gaccgcttct ctggctccaa gtctggcacc tcagccaccc tgggcatcac cggacttcag    240

actggggacg aggccgatta ttactgcgat tcttgggatt ctgctgatgc ttctggggtt    300

ttcggcggag ggaccaagct gaccgtccta                                     330


<210>  45
<211>  330
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Nucleotide sequence of light chain variable 
       domain sequence for anti-TIM-3 antibody clone 1H10

<400>  45
cagtctgtgc tgacgcagcc gccctcagtg tctgcggccc caggacagaa agtcaccatc     60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta ccagcagctc    120

ccaggaacag cccccaaact cctcatttat ggcaataatt ggcgaccctc agggattcct    180

gaccgcttct ctggctccaa gtctggcacc tcagccaccc tgggcatcac cggacttcag    240

actggggacg aggccgatta ttactgcgat tcttgggatt atgattatgc tgctggggtt    300

ttcggcggag ggaccaagct gaccgtccta                                     330


<210>  46
<211>  330
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Nucleotide sequence of light chain variable 
       domain sequence for anti-TIM-3 antibody clone 2C7

<400>  46
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa agtcaccatc     60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta ccagcagctc    120

ccaggaacag cccccaaact cctcatttat ggcaataatt ggcgaccctc agggattcct    180

gaccgcttct ctggctccaa gtctggcacc tcagccaccc tgggcatcac cggacttcag    240

actggggacg aggccgatta ttactgcgat tcttgggatt cttatcttgc tgctggggtt    300

ttcggcggag ggaccaagct gaccgtccta                                     330


<210>  47
<211>  330
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Nucleotide sequence of light chain variable 
       domain sequence for anti-TIM-3 antibody clone 2F4

<400>  47
cagtctgtgc tgacgcagcc gccctcagtg tctgcggccc caggacagaa agtcaccatc     60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta ccagcagctc    120

ccaggaacag cccccaaact cctcatttat ggcaataatt ggcgaccctc agggattcct    180

gaccgcttct ctggctccaa gtctggcacc tcagccaccc tgggcatcac cggacttcag    240

actggggacg aggccgatta ttactgcgaa tcttgggatt atgattatgc ttctggggtt    300

ttcggcggag ggaccaagct gaccgtccta                                     330


<210>  48
<211>  330
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Nucleotide sequence of light chain variable 
       domain sequence for anti-TIM-3 antibody clone 2G6

<400>  48
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa agtcaccatc     60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta ccagcagctc    120

ccaggaacag cccccaaact cctcatttat ggcaataatt ggcgaccctc agggattcct    180

gaccgcttct ctggctccaa gtctggcacc tcagccaccc tgggcatcac cggacttcag    240

actggggacg aggccgatta ttactgcgat tcttgggatt cttctgattc ttctggggtt    300

ttcggcggag ggaccaagct gaccgtccta                                     330


<210>  49
<211>  330
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Nucleotide sequence of light chain variable 
       domain sequence for anti-TIM-3 antibody clone 1D9

<400>  49
cagtctgtgc tgacgcagcc gccctcagtg tctgcggccc caggacagaa agtcaccatc     60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta ccagcagctc    120

ccaggaacag cccccaaact cctcatttat ggcaataatt ggcgaccctc agggattcct    180

gaccgcttct ctggctccaa gtctggcacc tcagccaccc tgggcatcac cggacttcag    240

actggggacg aggccgatta ttactgcgaa gcttgggatt ctgcttatgc tgctgggtct    300

ttcggcggag ggaccaagct gaccgtccta                                     330


<210>  50
<211>  330
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Nucleotide sequence of light chain variable 
       domain sequence for anti-TIM-3 antibody clone 1F4

<400>  50
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa agtcaccatc     60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta ccagcagctc    120

ccaggaacag cccccaaact cctcatttat ggcaataatt ggcgaccctc agggattcct    180

gaccgcttct ctggctccaa gtctggcacc tcagccaccc tgggcatcac cggacttcag    240

actggggacg aggccgatta ttactgcgat tcttgggatg ctgctctttc tgctggggtt    300

ttcggcggag ggaccaagct gaccgtccta                                     330


<210>  51
<211>  330
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Nucleotide sequence of light chain variable 
       domain sequence for anti-TIM-3 antibody clone 2C8

<400>  51
cagtctgtgc tgacgcagcc gccctcagtg tctgcggccc caggacagaa agtcaccatc     60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta ccagcagctc    120

ccaggaacag cccccaaact cctcatttat ggcaataatt ggcgaccctc agggattcct    180

gaccgcttct ctggctccaa gtctggcacc tcagccaccc tgggcatcac cggacttcag    240

actggggacg aggccgatta ttactgcgaa tcttgggatg ctgctgctgc tgctgggtat    300

ttcggcggag ggaccaagct gaccgtccta                                     330


<210>  52
<211>  348
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Nucleotide sequence of heavy chain variable 
       domain sequence for anti-TIM-3 antibody clone 1B9

<400>  52
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc     60

acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctggat ccgccagccc    120

ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac caactacaac    180

ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccttg    240

aaactgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag aggctatgtt    300

gctggctctg atgcttgggg ccagggaacc ctggtcaccg tctcaagc                 348


<210>  53
<211>  348
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Nucleotide sequence of heavy chain variable 
       domain sequence for anti-TIM-3 antibody clone 1H9

<400>  53
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc     60

acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctggat ccgccagccc    120

ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac caactacaac    180

ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccttg    240

aaactgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag aggctatgtt    300

gctggctttg atgattgggg ccagggaacc ctggtcaccg tctcaagc                 348


<210>  54
<211>  348
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Nucleotide sequence of heavy chain variable 
       domain sequence for anti-TIM-3 antibody clone 1H10

<400>  54
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc     60

acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctggat ccgccagccc    120

ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac caactacaac    180

ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccttg    240

aaactgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag aggctatgtt    300

gctggctttg attcttgggg ccagggaacc ctggtcaccg tctcaagc                 348


<210>  55
<211>  348
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Nucleotide sequence of heavy chain variable 
       domain sequence for anti-TIM-3 antibody clone 2C7

<400>  55
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc     60

acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctggat ccgccagccc    120

ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac caactacaac    180

ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccttg    240

aaactgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag aggctatgtt    300

gctggctatg attattgggg ccagggaacc ctggtcaccg tctcaagc                 348


<210>  56
<211>  348
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Nucleotide sequence of heavy chain variable 
       domain sequence for anti-TIM-3 antibody clone 2F4

<400>  56
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc     60

acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctggat ccgccagccc    120

ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac caactacaac    180

ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccttg    240

aaactgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag aggctatgtt    300

gctggctctg atgcttgggg ccagggaacc ctggtcaccg tctcaagc                 348


<210>  57
<211>  348
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Nucleotide sequence of heavy chain variable 
       domain sequence for anti-TIM-3 antibody clone 2G6

<400>  57
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc     60

acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctggat ccgccagccc    120

ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac caactacaac    180

ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccttg    240

aaactgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag aggctatgtt    300

gctggctttg attcttgggg ccagggaacc ctggtcaccg tctcaagc                 348


<210>  58
<211>  348
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Nucleotide sequence of heavy chain variable 
       domain sequence for anti-TIM-3 antibody clone 1D9

<400>  58
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc     60

acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctggat ccgccagccc    120

ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac caactacaac    180

ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccttg    240

aaactgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag aggctattat    300

gctggcgatg attattgggg ccagggaacc ctggtcaccg tctcaagc                 348


<210>  59
<211>  348
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Nucleotide sequence of heavy chain variable 
       domain sequence for anti-TIM-3 antibody clone 1F4

<400>  59
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc     60

acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctggat ccgccagccc    120

ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac caactacaac    180

ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccttg    240

aaactgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag aggctatgtt    300

gctggctatg attattgggg ccagggaacc ctggtcaccg tctcaagc                 348


<210>  60
<211>  348
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Nucleotide sequence of heavy chain variable 
       domain sequence for anti-TIM-3 antibody clone 2C8

<400>  60
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc     60

acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctggat ccgccagccc    120

ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac caactacaac    180

ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccttg    240

aaactgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag aggctatgtt    300

gctggctctg atgcttgggg ccagggaacc ctggtcaccg tctcaagc                 348


<210>  61
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: HC-CDR1

<400>  61

Gly Tyr Tyr Trp Ser 
1               5   


