                         SEQUENCE LISTING

<110>  Bicycle Therapeutics Limited
 
<120>  BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR MT1-MMP

<130>  BIC-C-P1803PCT

<150>  GB1419237.1
<151>  2014-10-29

<150>  GB1515245.7
<151>  2015-08-27

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa represents either a polar, uncharged amino acid residue 
       selected from N, C, Q, M, S and T or a non-polar aliphatic amino 
       acid residue selected from G, A, I, L, P and V

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Xaa can be any naturally occurring amino acid

<400>  1

Cys Xaa Xaa Xaa Xaa Gly Cys Glu Asp Phe Tyr Xaa Xaa Cys 
1               5                   10                  


<210>  2
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  2

Cys Tyr Asn Glu Phe Gly Cys Glu Asp Phe Tyr Asp Ile Cys 
1               5                   10                  


<210>  3
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is beta Ala

<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Sar10

<400>  3

Xaa Xaa Ala Cys Tyr Asn Glu Phe Gly Cys Glu Asp Phe Tyr Asp Ile 
1               5                   10                  15      


Cys 
    


<210>  4
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is D-Ala

<400>  4

Cys Xaa Asn Glu Phe Gly Cys Glu Asp Phe Tyr Asp Ile Cys 
1               5                   10                  


<210>  5
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is Beta Ala

<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Sar10

<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa is D-Ala

<220>
<221>  Xaa
<222>  (8)..(8)
<223>  Xaa is NAl

<220>
<221>  Xaa
<222>  (9)..(9)
<223>  Xaa is D-Ala

<220>
<221>  Xaa
<222>  (16)..(16)
<223>  Xaa is tBuGly

<400>  5

Xaa Xaa Ala Cys Xaa Asn Glu Xaa Xaa Cys Glu Asp Phe Tyr Asp Xaa 
1               5                   10                  15      


Cys 
    


<210>  6
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Y, M, F or V

<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa represents a polar, uncharged amino acid residue selected 
       from N, C, Q, M, S and T or a non-polar aliphatic amino acid 
       residue selected from G, A, I, L, P and V

<220>
<221>  Xaa
<222>  (4)..(4)
<223>  Xaa represents a polar, uncharged amino acid residue selected 
       from N, C, Q, M, S and T or a polar, negatively charged amino 
       acid residue selected from D or E

<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa represents a non-polar aromatic amino acid residue selected 
       from F, W and Y

<220>
<221>  Xaa
<222>  (12)..(12)
<223>  Xaa represents a polar, negatively charged amino acid residue 
       selected from D or E

<220>
<221>  Xaa
<222>  (13)..(13)
<223>  Xaa represents a non-polar aliphatic amino acid residue selected 
       from G, A, I, L, P and V

<400>  6

Cys Xaa Xaa Xaa Xaa Gly Cys Glu Asp Phe Tyr Xaa Xaa Cys 
1               5                   10                  


<210>  7
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Y, M, F or V

<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is N or G

<220>
<221>  Xaa
<222>  (4)..(4)
<223>  Xaa is E or Q

<400>  7

Cys Xaa Xaa Xaa Phe Gly Cys Glu Asp Phe Tyr Asp Ile Cys 
1               5                   10                  


<210>  8
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Y, M or F

<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is N or G

<220>
<221>  Xaa
<222>  (4)..(4)
<223>  Xaa is E or Q

<400>  8

Cys Xaa Xaa Xaa Phe Gly Cys Glu Asp Phe Tyr Asp Ile Cys 
1               5                   10                  


<210>  9
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Y or M

<220>
<221>  Xaa
<222>  (4)..(4)
<223>  Xaa is E or Q

<400>  9

Cys Xaa Asn Xaa Phe Gly Cys Glu Asp Phe Tyr Asp Ile Cys 
1               5                   10                  


<210>  10
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  10

Cys Met Asn Gln Phe Gly Cys Glu Asp Phe Tyr Asp Ile Cys 
1               5                   10                  


<210>  11
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  11

Cys Phe Gly Glu Phe Gly Cys Glu Asp Phe Tyr Asp Ile Cys 
1               5                   10                  


<210>  12
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  12

Cys Val Asn Glu Phe Gly Cys Glu Asp Phe Tyr Asp Ile Cys 
1               5                   10                  


<210>  13
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  13

Cys Phe Asn Glu Phe Gly Cys Glu Asp Phe Tyr Asp Ile Cys 
1               5                   10                  


<210>  14
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  14

Cys Tyr Asn Glu Tyr Gly Cys Glu Asp Phe Tyr Asp Ile Cys 
1               5                   10                  


<210>  15
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  15

Cys Tyr Asn Glu Trp Gly Cys Glu Asp Phe Tyr Asp Ile Cys 
1               5                   10                  


<210>  16
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  16

Cys Lys Asn Arg Gly Phe Gly Cys Glu Asp Phe Tyr Asp Ile Cys 
1               5                   10                  15  


<210>  17
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  17

Cys Glu Asp Phe Tyr Asp Ile Cys 
1               5               


<210>  18
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  18

Ala Cys Tyr Asn Glu Phe Gly Cys Glu Asp Phe Tyr Asp Ile Cys Ala 
1               5                   10                  15      


<210>  19
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  19

Ala Cys Met Asn Gln Phe Gly Cys Glu Asp Phe Tyr Asp Ile Cys Ala 
1               5                   10                  15      


<210>  20
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is Sar10

<400>  20

Gly Xaa Ala Cys Tyr Asn Glu Phe Gly Cys Glu Asp Phe Tyr Asp Ile 
1               5                   10                  15      


Cys 
    


<210>  21
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  21

Tyr Asn Glu Phe 
1               


<210>  22
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  22

Tyr Asn Glu Phe Gly 
1               5   


<210>  23
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  23

Glu Asp Phe Tyr Asp Ile 
1               5       


