                         SEQUENCE LISTING

<110>  Novozymes A/S
 
<120>  Filamentous fungal double-mutant host cells

<130>  NZ12887-WO-PCT

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  7368
<212>  DNA
<213>  aspergillus niger

<400>  1
atgttcggca cgacggttca gcgctgcgtg gtgctcattc tggggatact cagcgtcacg       60

accgtgggct ggccctacga tgagtcgctc gttgattaca acctgaacga gaacaagacc      120

gcagagggac cgataaacta ttggggagaa tggccagatc acacctatca tccgtcacca      180

gacaactggc gcttccccat ctataccatc ttcctggatc gcatcgccaa cggagatccc      240

gctaatgacg atattaacgg caccacctac gagcatgtac tcgattcgaa tcagatgcgc      300

catggcggtg acctagtcgg cttgattgac acgctcgatt acatcagagg catgggcttc      360

aaggtgagtc tattccattg atatcagttc ccggtccatc cttgactgac tgactgatca      420

ttctagggaa tctacttcgc tggtacgggc ttgatgaatc ttccctgggg ctacgatggt      480

tactccccgg tggataccac cctcctcgac aagcaccatg gcaccctgtc cgactggagg      540

cggaccatca aggagatcca cgaccgggat atgtatgtga tcatggataa tacattagca      600

acgtgagtat gcaccgagta ttctagacga ccatgccact aacaatctcc ccgtgcagtt      660

tgagtaacct gatcggtttc aagggccact tgaacgattc ggctgatttc aatgcgaaag      720

agtacgaggt ggagtacgtc accgagagaa cgtacgccga tttccagttc agcaatgact      780

acaatgacac ctgcaactac ccgaaattct ggaacgagac gggatacccg ttgacgtccg      840

gtggcgtgca agacctgaag ggttgctaca acagtgattt cgatcagtat ggcgaactcg      900

aggcgtttgg taatttcccc gactggaagc gacagctcac gaaattcgct tcggtgcaag      960

atcgtctgcg agaatggcac aagccggttc gcgatgtcat cacccggcat tcctgcattg     1020

tgatcgccag tttggacatt gatggcttcc ggtttgataa ggccgtccag gccactctgg     1080

atccgctggg tgacatgcta gcggtctacc gtgaatgtgc caagcaatat ggcaagaaga     1140

acttcttcct gccgggagag atcacttcgg gaaacacctt tggtagtctc tatcttggcc     1200

ggggtcgtca gccaaaccag acgcccgatt cggcagacgc tggcgcgaag ttgacgaatg     1260

cttcgtcgga ttcctacttc ctccgcgatg atggcctgca ggcgttggac gctgcagcct     1320

ttcactacac catctatcgt tcgatgaccc gtttcctggg aatggacggg aacctggtgg     1380

ccggctttga cctgcccact gatttcatcg aagcctggaa tggcatgctc gtcactaacg     1440

acttcatcaa tgccttcacg ggcgagttgg atcccagaca tatgtatgga gtgtcgaacc     1500

aggataactt tcgctggccc gccatcaaga atggtacgga gaaatacctg ctgggtctat     1560

acattgttac gctggagctg ccgggaatcc ctttggttct ctggggcgag gagcaggaga     1620

tgtacgtgtt cgatgcgact gcgtccaact atctgttcgg tcggcaaccc atgacttacc     1680

agacggcgtg gtggacgcat ggctgcttct cgctaaacac ctcgaaattc tacgatttcc     1740

ccaacgacaa gggattgaat ggttgcaacg atatcacagt gacttacgac caacggaatc     1800

cggcgcaccc ccttcgcaac atcatgaagc gcatgtttga gattcgggag cagtacccag     1860

tggccaatga tggcttcaac cttgagacca tttcccagct tacccaggat atctatcttc     1920

cgggttcatc gactaccccg acggtgactg gtctctggtc agtgctgcgc agctactacc     1980

ccggggttca gaaagaggcc tcgagtagca acgatactct ttggcttgta tatcataatg     2040

ccaataaaac ggaaacctat ggcaagaact gtactagcaa ggactccgct cttctgtccc     2100

cttacgagtc gggcacgaag ttgaaaaacc tcttctatcc ctacgatgaa ctcacgctgc     2160

aggatggacc aagtgacgct agcaacggca ccgagtccta cgggtgcacg accaacatga     2220

aattgctgcc atgggaattc cgggcttacg tcaaggcgag cgacttcgtt gaacctggcc     2280

ctaccgtcac cgagtttgtc cccggccacg atgctcgcct gctgtcttcc gaggatactg     2340

gggaaacact gaagatccag ctgggctact ccaaggccat ggactgcagt gccatcacga     2400

aagcagtctc cctgaattcg accaccgtca agggcgtcaa tgccaccctt gacacctcta     2460

gcgtgagctg caccaacgtc accgccagga cgagcagtaa taactacatc ggcgaggttc     2520

ccactgtttg gacctggtcc gcgaacctga caaacgtcta tcacggaatc caccagctca     2580

ccgtcaagaa tgcctccacg acgtctggaa cgcgcgtaga tgccatcgac cgctttttat     2640

tccgagtcgg aacccacacc aacccgttaa tatcgccact ggccaactac tctaccagcc     2700

tcgtccatca gtcggataac ggcagctact atgttcagca tgatgcggcc ggcgctgacc     2760

agttccgcta cacgaccgac tttggcctga actggtccaa ctggacagac tacactggtg     2820

gtaacacgac gattgaattt ccgacttgga ccggcacaga tgctcaaaag tgggagggca     2880

ctcacattcg cgtccagtat ttctcccgcc ttaccggcag cagtgattac atccaggagg     2940

gtgattatga ctgggaatcc ggtgtccctc gcagatttcc ccatctgtgg tggaatggcc     3000

cgtacaacca atacggttat gatgccggtc tggacagcaa gatgcggttt gatactaagg     3060

atcgccgctg gaaatatgat ttcgtttatg aatggccgtc cgtcggacag atcagtgtct     3120

ggggcactgg caaggacggt gttccggaga caacgaatgt ttatggcgat gttgacaact     3180

catcggttgt acaggtcttg cctccctcct acttgtcgtc gaacgtgatt aatatcaccg     3240

agctgccccc cttcccgcac cttggctgga ccatctctct caatgatgcc aacctccgct     3300

atgaattgct tccggtcgga tctggatggg cccagctggt actttacatc cttctctggg     3360

tcgtccctat cttgatgggg ctggcgggag ttttcatctt catccgcacc ttctaccgtg     3420

ttgagctgaa taccgatggc aatgttgtta aggaggacaa gctgccgctg ttgttctggc     3480

gcaggatgaa gggccaatct ggaggtgatg gccagatgga ccgggaagaa tcagatgtcg     3540

ccgccgtggc aggcgaaatg gccattgcag gagcccccga gaaacgccgc acggtcttga     3600

tcgccaccat ggagtacgat attgcggatt ggcaggccaa ggtcaagatt ggtggtctgg     3660

gagtcatggc ccagctcatg tcccaaaacc tgggatatca gaatcttatc tgggtggttc     3720

cctgcgtggg agacatcgaa tatcccgagg ataccccgac agagccatac atcgtgaaga     3780

tcctcgacaa cccctatctc gtcaatgtgc agtatcacgt tctcaacaat atcacctacg     3840

tccttcttga cgctcctgtg ttccgccagc agacaaaagc cgagccgtat cctccccgca     3900

tggatgacct ggatagcgcc atttactact ccgcctggaa ccaatgtatc gcagagacca     3960

tcaagcgctt cccgtccatc gatctgtatc acatcaacga tttccacgga tgcctggcac     4020

cgttgtacct cctgcccaca cgcacgatcc ccgtgtgttt gtctctccac aacgccgagt     4080

tccagggtct ctggcccctc cggacccagc aagaaaagaa ggaagtctgt tcggtcttca     4140

acctccccgt cgagacggct accaaatatt gtcaattcgg taatgtgttc aacttgcttc     4200

acacaggagc gagttacctt cggttccatc agcgcgggtt tggcgcggtc ggtgtgtcaa     4260

agaagtacgg aaagcgttcc tgggctcggt atcctatttt ctggagtttg gacaagatcg     4320

gtagtctgcc caaccctgac ccaactgata cggcggccct ggaggatact cctgacgaga     4380

aagctctgac tcggtcatat gaggaacgga tcactgacaa gctcgaggcc cagaagtggg     4440

ctggcctgac cgaggatcgc aacgccgacc tcctggtgtt cgtcggtcgc tggtctaagc     4500

agaagggtgt cgatctgatt gcggatgtca tccccgccgt tctgtctgac cggccgcagg     4560

tgcaggtgat ctgtgttggt cccatcatcg atctttacgg aagactggct gccattaagc     4620

tggagaagat cgctgccatg ttccctggcc gggtcttctc ccgacctgag ttcactgctt     4680

tgcccccgtg tgtcttctct ggcgctgact tcgctctgat cccgtctcgt gatgagccat     4740

ttggattgat tgccgttgag ttcggtcgga agggtgcact gggaatcgga tctcgcatcg     4800

gaggtttggg tcagatgcca ggctggtggt acaccgttga atcagacgcc actcgccatc     4860

ttctacacca gctgaagact gcgatcaaat ctgccctgga ttcgactcct gaaactcgag     4920

cccagatgcg cgcaaactcc gctaagcagc gattccccgt tctcgagtgg atccagaaac     4980

tcgagacttt gcagcggaca tcgatcaaga ttcatcatga caagaacaag gacaccgtga     5040

ctggttcgat cccggagtct gagagcgtat gggacctgca aaaccttcag agtgcgcgct     5100

attccagtgt ggcacttcct aatatggctc tgtccagagc ggacggcacg gaaaccccgc     5160

ctgaagccat gatccagcag gcccacgctc gccttcaaga gatccaggca tccgagggaa     5220

gcagtcgcga cagcagcctc aaccgcaaac tgtcactggg tcgccggtcc ggccctggtc     5280

agggcagaaa gcgcttgacg aagaggcaag cgaccgcaag ccaggcatcc actgatcacg     5340

gagaagatga gaacgatacc gacgctgacg acgaccacac caggccgcag gaggattaca     5400

tttctcccga ggaggccatg caggccgtta acaacactct aactccccat gctatcactg     5460

gagacagtac tccccgcgcc tcctacttgt ctagacccgt atccccgtac cccatctcac     5520

agatctctac tccagcgtgc ccgacaccgc cacccatgac tcacttccgg accgtttcta     5580

tgctgtcgtt gccatccgtt gttggggacc ataaccgcct cagcagtctc ggcggcgagg     5640

agcagaacca gcccgtcttc gagttgcaga aggtggaccc gactttcacg gacagcttgg     5700

gccacttcac ccggcgcttc gagcagtcgc ttgagaagtt gaacaagaag aactccatca     5760

cggactattg cattgaggtc tatctgatga agagtgagcg caagttctac aattcataca     5820

acgacgccca gcttaagaag cagcctaaga accgttcgct cgcggttccc agctctgaga     5880

gtgttgtgca agaagggccc ggtggctcag tcgttcgtca ctcgtactcc agtgaggatt     5940

ctgaaatcaa tggggaggat gagattgacc gctggctgat gcggttgggt tacacgcgtc     6000

cgatcgcagt tcagcgattc atgagacgcc gcttgggcaa ttggccagtg tattcactat     6060

tcctgggtct gggtcagatc atcgccacca actccgcaca aatcaccctg cttgtcggcc     6120

aggtcggaga gaccgctgtg aagctttatg tcatcgccgc tatctactgc ctgtcctcca     6180

tcgcgtggtg gttcctgtat catcggttcc cagccgtcat ctccctcagt cttccctggt     6240

tcatctactg catggcattc atcgttatcg gtgtttcacc cttcggtctc acggctctcg     6300

gtcgggcctg ggctcagaat gttgcggctg gcgtctacgc cattgcgtcg tctagcggtt     6360

ccttgttctt cgctctgaac tttggagacc agggtgccgt ccctgtcaag gactggatgt     6420

tccgcgccag tatcattcaa ggtatctcac agatctacac ggtcgcgctc tggttctgga     6480

gctccaaggt cactgccgcc gaagtgggag gtgtatctgt agcggccttg agctcctggc     6540

gtctcacggc cgtggtgatg cccattgctg ccctgtgctt cgtgatcgga gtcctgctgg     6600

ccctgggatt gcccaactac taccgtcaag ctcccagccg tatcctgttc ttctacaagt     6660

ctctgttccg ccgacgcatc atcctgtggt tcttcttcat ggtcatcgtc cagaactggt     6720

tccttgctgc cgctttcggc cgcaactggt ccttcctctg gtcgtccaaa cacaccaagc     6780

cctgggagat tgtcctcctt gtgttcggct tcttcgtcgt cctatgggta gtcattcttg     6840

tcatattccg tgccctgtcg aaggaacaca gctggatctt gccagttttc ggtctgagtc     6900

tgggtgctcc ccggtgggca caaacctggt ggggaacctc caacatcggc tactatctcc     6960

cttgggctgg cagcttggtg tcggggtcga tcgcttcccg ctgcctgtgg ctctggctgg     7020

gactccttga cgagatccaa caagtcggat tgggtatgat tctgctgcag accatgactc     7080

gcgtgcatgt ctgcttcgtc ctgttggccg cgcaagcact gggatccatc gccaccatct     7140

gcgcccgcgg cttcgcgccg aacaagattg gccctgggga tatctctccg gatgtgggca     7200

cgtcggtgga caaggtcggt aacgcatggt tctggatcgc tctcttcttc cagctcctgg     7260

caaggtaagc cttcccacac tttcttttct cacgcgagct ttatctaacg tttgaacagt     7320

tggggcttcc tgctcttcta ccgccgcgaa cagctcaacc gaccctaa                  7368


<210>  2
<211>  7194
<212>  DNA
<213>  aspergillus niger


<220>
<221>  CDS
<222>  (1)..(7191)
<223>  AgsA encoding cDNA

<400>  2
atg ttc ggc acg acg gtt cag cgc tgc gtg gtg ctc att ctg ggg ata         48
Met Phe Gly Thr Thr Val Gln Arg Cys Val Val Leu Ile Leu Gly Ile           
1               5                   10                  15                

ctc agc gtc acg acc gtg ggc tgg ccc tac gat gag tcg ctc gtt gat         96
Leu Ser Val Thr Thr Val Gly Trp Pro Tyr Asp Glu Ser Leu Val Asp           
            20                  25                  30                    

tac aac ctg aac gag aac aag acc gca gag gga ccg ata aac tat tgg        144
Tyr Asn Leu Asn Glu Asn Lys Thr Ala Glu Gly Pro Ile Asn Tyr Trp           
        35                  40                  45                        

gga gaa tgg cca gat cac acc tat cat ccg tca cca gac aac tgg cgc        192
Gly Glu Trp Pro Asp His Thr Tyr His Pro Ser Pro Asp Asn Trp Arg           
    50                  55                  60                            

ttc ccc atc tat acc atc ttc ctg gat cgc atc gcc aac gga gat ccc        240
Phe Pro Ile Tyr Thr Ile Phe Leu Asp Arg Ile Ala Asn Gly Asp Pro           
65                  70                  75                  80            

gct aat gac gat att aac ggc acc acc tac gag cat gta ctc gat tcg        288
Ala Asn Asp Asp Ile Asn Gly Thr Thr Tyr Glu His Val Leu Asp Ser           
                85                  90                  95                

aat cag atg cgc cat ggc ggt gac cta gtc ggc ttg att gac acg ctc        336
Asn Gln Met Arg His Gly Gly Asp Leu Val Gly Leu Ile Asp Thr Leu           
            100                 105                 110                   

gat tac atc aga ggc atg ggc ttc aag gga atc tac ttc gct ggt acg        384
Asp Tyr Ile Arg Gly Met Gly Phe Lys Gly Ile Tyr Phe Ala Gly Thr           
        115                 120                 125                       

ggc ttg atg aat ctt ccc tgg ggc tac gat ggt tac tcc ccg gtg gat        432
Gly Leu Met Asn Leu Pro Trp Gly Tyr Asp Gly Tyr Ser Pro Val Asp           
    130                 135                 140                           

acc acc ctc ctc gac aag cac cat ggc acc ctg tcc gac tgg agg cgg        480
Thr Thr Leu Leu Asp Lys His His Gly Thr Leu Ser Asp Trp Arg Arg           
145                 150                 155                 160           

acc atc aag gag atc cac gac cgg gat atg tat gtg atc atg gat aat        528
Thr Ile Lys Glu Ile His Asp Arg Asp Met Tyr Val Ile Met Asp Asn           
                165                 170                 175               

aca tta gca act ttg agt aac ctg atc ggt ttc aag ggc cac ttg aac        576
Thr Leu Ala Thr Leu Ser Asn Leu Ile Gly Phe Lys Gly His Leu Asn           
            180                 185                 190                   

gat tcg gct gat ttc aat gcg aaa gag tac gag gtg gag tac gtc acc        624
Asp Ser Ala Asp Phe Asn Ala Lys Glu Tyr Glu Val Glu Tyr Val Thr           
        195                 200                 205                       

gag aga acg tac gcc gat ttc cag ttc agc aat gac tac aat gac acc        672
Glu Arg Thr Tyr Ala Asp Phe Gln Phe Ser Asn Asp Tyr Asn Asp Thr           
    210                 215                 220                           

tgc aac tac ccg aaa ttc tgg aac gag acg gga tac ccg ttg acg tcc        720
Cys Asn Tyr Pro Lys Phe Trp Asn Glu Thr Gly Tyr Pro Leu Thr Ser           
225                 230                 235                 240           

ggt ggc gtg caa gac ctg aag ggt tgc tac aac agt gat ttc gat cag        768
Gly Gly Val Gln Asp Leu Lys Gly Cys Tyr Asn Ser Asp Phe Asp Gln           
                245                 250                 255               

tat ggc gaa ctc gag gcg ttt ggt aat ttc ccc gac tgg aag cga cag        816
Tyr Gly Glu Leu Glu Ala Phe Gly Asn Phe Pro Asp Trp Lys Arg Gln           
            260                 265                 270                   

ctc acg aaa ttc gct tcg gtg caa gat cgt ctg cga gaa tgg cac aag        864
Leu Thr Lys Phe Ala Ser Val Gln Asp Arg Leu Arg Glu Trp His Lys           
        275                 280                 285                       

ccg gtt cgc gat gtc atc acc cgg cat tcc tgc att gtg atc gcc agt        912
Pro Val Arg Asp Val Ile Thr Arg His Ser Cys Ile Val Ile Ala Ser           
    290                 295                 300                           

ttg gac att gat ggc ttc cgg ttt gat aag gcc gtc cag gcc act ctg        960
Leu Asp Ile Asp Gly Phe Arg Phe Asp Lys Ala Val Gln Ala Thr Leu           
305                 310                 315                 320           

gat ccg ctg ggt gac atg cta gcg gtc tac cgt gaa tgt gcc aag caa       1008
Asp Pro Leu Gly Asp Met Leu Ala Val Tyr Arg Glu Cys Ala Lys Gln           
                325                 330                 335               

tat ggc aag aag aac ttc ttc ctg ccg gga gag atc act tcg gga aac       1056
Tyr Gly Lys Lys Asn Phe Phe Leu Pro Gly Glu Ile Thr Ser Gly Asn           
            340                 345                 350                   

acc ttt ggt agt ctc tat ctt ggc cgg ggt cgt cag cca aac cag acg       1104
Thr Phe Gly Ser Leu Tyr Leu Gly Arg Gly Arg Gln Pro Asn Gln Thr           
        355                 360                 365                       

ccc gat tcg gca gac gct ggc gcg aag ttg acg aat gct tcg tcg gat       1152
Pro Asp Ser Ala Asp Ala Gly Ala Lys Leu Thr Asn Ala Ser Ser Asp           
    370                 375                 380                           

tcc tac ttc ctc cgc gat gat ggc ctg cag gcg ttg gac gct gca gcc       1200
Ser Tyr Phe Leu Arg Asp Asp Gly Leu Gln Ala Leu Asp Ala Ala Ala           
385                 390                 395                 400           

ttt cac tac acc atc tat cgt tcg atg acc cgt ttc ctg gga atg gac       1248
Phe His Tyr Thr Ile Tyr Arg Ser Met Thr Arg Phe Leu Gly Met Asp           
                405                 410                 415               

ggg aac ctg gtg gcc ggc ttt gac ctg ccc act gat ttc atc gaa gcc       1296
Gly Asn Leu Val Ala Gly Phe Asp Leu Pro Thr Asp Phe Ile Glu Ala           
            420                 425                 430                   

tgg aat ggc atg ctc gtc act aac gac ttc atc aat gcc ttc acg ggc       1344
Trp Asn Gly Met Leu Val Thr Asn Asp Phe Ile Asn Ala Phe Thr Gly           
        435                 440                 445                       

gag ttg gat ccc aga cat atg tat gga gtg tcg aac cag gat aac ttt       1392
Glu Leu Asp Pro Arg His Met Tyr Gly Val Ser Asn Gln Asp Asn Phe           
    450                 455                 460                           

cgc tgg ccc gcc atc aag aat ggt acg gag aaa tac ctg ctg ggt cta       1440
Arg Trp Pro Ala Ile Lys Asn Gly Thr Glu Lys Tyr Leu Leu Gly Leu           
465                 470                 475                 480           

tac att gtt acg ctg gag ctg ccg gga atc cct ttg gtt ctc tgg ggc       1488
Tyr Ile Val Thr Leu Glu Leu Pro Gly Ile Pro Leu Val Leu Trp Gly           
                485                 490                 495               

gag gag cag gag atg tac gtg ttc gat gcg act gcg tcc aac tat ctg       1536
Glu Glu Gln Glu Met Tyr Val Phe Asp Ala Thr Ala Ser Asn Tyr Leu           
            500                 505                 510                   

ttc ggt cgg caa ccc atg act tac cag acg gcg tgg tgg acg cat ggc       1584
Phe Gly Arg Gln Pro Met Thr Tyr Gln Thr Ala Trp Trp Thr His Gly           
        515                 520                 525                       

tgc ttc tcg cta aac acc tcg aaa ttc tac gat ttc ccc aac gac aag       1632
Cys Phe Ser Leu Asn Thr Ser Lys Phe Tyr Asp Phe Pro Asn Asp Lys           
    530                 535                 540                           

gga ttg aat ggt tgc aac gat atc aca gtg act tac gac caa cgg aat       1680
Gly Leu Asn Gly Cys Asn Asp Ile Thr Val Thr Tyr Asp Gln Arg Asn           
545                 550                 555                 560           

ccg gcg cac ccc ctt cgc aac atc atg aag cgc atg ttt gag att cgg       1728
Pro Ala His Pro Leu Arg Asn Ile Met Lys Arg Met Phe Glu Ile Arg           
                565                 570                 575               

gag cag tac cca gtg gcc aat gat ggc ttc aac ctt gag acc att tcc       1776
Glu Gln Tyr Pro Val Ala Asn Asp Gly Phe Asn Leu Glu Thr Ile Ser           
            580                 585                 590                   

cag ctt acc cag gat atc tat ctt ccg ggt tca tcg act acc ccg acg       1824
Gln Leu Thr Gln Asp Ile Tyr Leu Pro Gly Ser Ser Thr Thr Pro Thr           
        595                 600                 605                       

gtg act ggt ctc tgg tca gtg ctg cgc agc tac tac ccc ggg gtt cag       1872
Val Thr Gly Leu Trp Ser Val Leu Arg Ser Tyr Tyr Pro Gly Val Gln           
    610                 615                 620                           

aaa gag gcc tcg agt agc aac gat act ctt tgg ctt gta tat cat aat       1920
Lys Glu Ala Ser Ser Ser Asn Asp Thr Leu Trp Leu Val Tyr His Asn           
625                 630                 635                 640           

gcc aat aaa acg gaa acc tat ggc aag aac tgt act agc aag gac tcc       1968
Ala Asn Lys Thr Glu Thr Tyr Gly Lys Asn Cys Thr Ser Lys Asp Ser           
                645                 650                 655               

gct ctt ctg tcc cct tac gag tcg ggc acg aag ttg aaa aac ctc ttc       2016
Ala Leu Leu Ser Pro Tyr Glu Ser Gly Thr Lys Leu Lys Asn Leu Phe           
            660                 665                 670                   

tat ccc tac gat gaa ctc acg ctg cag gat gga cca agt gac gct agc       2064
Tyr Pro Tyr Asp Glu Leu Thr Leu Gln Asp Gly Pro Ser Asp Ala Ser           
        675                 680                 685                       

aac ggc acc gag tcc tac ggg tgc acg acc aac atg aaa ttg ctg cca       2112
Asn Gly Thr Glu Ser Tyr Gly Cys Thr Thr Asn Met Lys Leu Leu Pro           
    690                 695                 700                           

tgg gaa ttc cgg gct tac gtc aag gcg agc gac ttc gtt gaa cct ggc       2160
Trp Glu Phe Arg Ala Tyr Val Lys Ala Ser Asp Phe Val Glu Pro Gly           
705                 710                 715                 720           

cct acc gtc acc gag ttt gtc ccc ggc cac gat gct cgc ctg ctg tct       2208
Pro Thr Val Thr Glu Phe Val Pro Gly His Asp Ala Arg Leu Leu Ser           
                725                 730                 735               

tcc gag gat act ggg gaa aca ctg aag atc cag ctg ggc tac tcc aag       2256
Ser Glu Asp Thr Gly Glu Thr Leu Lys Ile Gln Leu Gly Tyr Ser Lys           
            740                 745                 750                   

gcc atg gac tgc agt gcc atc acg aaa gca gtc tcc ctg aat tcg acc       2304
Ala Met Asp Cys Ser Ala Ile Thr Lys Ala Val Ser Leu Asn Ser Thr           
        755                 760                 765                       

acc gtc aag ggc gtc aat gcc acc ctt gac acc tct agc gtg agc tgc       2352
Thr Val Lys Gly Val Asn Ala Thr Leu Asp Thr Ser Ser Val Ser Cys           
    770                 775                 780                           

acc aac gtc acc gcc agg acg agc agt aat aac tac atc ggc gag gtt       2400
Thr Asn Val Thr Ala Arg Thr Ser Ser Asn Asn Tyr Ile Gly Glu Val           
785                 790                 795                 800           

ccc act gtt tgg acc tgg tcc gcg aac ctg aca aac gtc tat cac gga       2448
Pro Thr Val Trp Thr Trp Ser Ala Asn Leu Thr Asn Val Tyr His Gly           
                805                 810                 815               

atc cac cag ctc acc gtc aag aat gcc tcc acg acg tct gga acg cgc       2496
Ile His Gln Leu Thr Val Lys Asn Ala Ser Thr Thr Ser Gly Thr Arg           
            820                 825                 830                   

gta gat gcc atc gac cgc ttt tta ttc cga gtc gga acc cac acc aac       2544
Val Asp Ala Ile Asp Arg Phe Leu Phe Arg Val Gly Thr His Thr Asn           
        835                 840                 845                       

ccg tta ata tcg cca ctg gcc aac tac tct acc agc ctc gtc cat cag       2592
Pro Leu Ile Ser Pro Leu Ala Asn Tyr Ser Thr Ser Leu Val His Gln           
    850                 855                 860                           

tcg gat aac ggc agc tac tat gtt cag cat gat gcg gcc ggc gct gac       2640
Ser Asp Asn Gly Ser Tyr Tyr Val Gln His Asp Ala Ala Gly Ala Asp           
865                 870                 875                 880           

cag ttc cgc tac acg acc gac ttt ggc ctg aac tgg tcc aac tgg aca       2688
Gln Phe Arg Tyr Thr Thr Asp Phe Gly Leu Asn Trp Ser Asn Trp Thr           
                885                 890                 895               

gac tac act ggt ggt aac acg acg att gaa ttt ccg act tgg acc ggc       2736
Asp Tyr Thr Gly Gly Asn Thr Thr Ile Glu Phe Pro Thr Trp Thr Gly           
            900                 905                 910                   

aca gat gct caa aag tgg gag ggc act cac att cgc gtc cag tat ttc       2784
Thr Asp Ala Gln Lys Trp Glu Gly Thr His Ile Arg Val Gln Tyr Phe           
        915                 920                 925                       

tcc cgc ctt acc ggc agc agt gat tac atc cag gag ggt gat tat gac       2832
Ser Arg Leu Thr Gly Ser Ser Asp Tyr Ile Gln Glu Gly Asp Tyr Asp           
    930                 935                 940                           

tgg gaa tcc ggt gtc cct cgc aga ttt ccc cat ctg tgg tgg aat ggc       2880
Trp Glu Ser Gly Val Pro Arg Arg Phe Pro His Leu Trp Trp Asn Gly           
945                 950                 955                 960           

ccg tac aac caa tac ggt tat gat gcc ggt ctg gac agc aag atg cgg       2928
Pro Tyr Asn Gln Tyr Gly Tyr Asp Ala Gly Leu Asp Ser Lys Met Arg           
                965                 970                 975               

ttt gat act aag gat cgc cgc tgg aaa tat gat ttc gtt tat gaa tgg       2976
Phe Asp Thr Lys Asp Arg Arg Trp Lys Tyr Asp Phe Val Tyr Glu Trp           
            980                 985                 990                   

ccg tcc gtc gga cag atc agt gtc  tgg ggc act ggc aag  gac ggt gtt     3024
Pro Ser Val Gly Gln Ile Ser Val  Trp Gly Thr Gly Lys  Asp Gly Val         
        995                 1000                 1005                     

ccg gag  aca acg aat gtt tat  ggc gat gtt gac aac  tca tcg gtt        3069
Pro Glu  Thr Thr Asn Val Tyr  Gly Asp Val Asp Asn  Ser Ser Val            
    1010                 1015                 1020                        

gta cag  gtc ttg cct ccc tcc  tac ttg tcg tcg aac  gtg att aat        3114
Val Gln  Val Leu Pro Pro Ser  Tyr Leu Ser Ser Asn  Val Ile Asn            
    1025                 1030                 1035                        

atc acc  gag ctg ccc ccc ttc  ccg cac ctt ggc tgg  acc atc tct        3159
Ile Thr  Glu Leu Pro Pro Phe  Pro His Leu Gly Trp  Thr Ile Ser            
    1040                 1045                 1050                        

ctc aat  gat gcc aac ctc cgc  tat gaa ttg ctt ccg  gtc gga tct        3204
Leu Asn  Asp Ala Asn Leu Arg  Tyr Glu Leu Leu Pro  Val Gly Ser            
    1055                 1060                 1065                        

gga tgg  gcc cag ctg gta ctt  tac atc ctt ctc tgg  gtc gtc cct        3249
Gly Trp  Ala Gln Leu Val Leu  Tyr Ile Leu Leu Trp  Val Val Pro            
    1070                 1075                 1080                        

atc ttg  atg ggg ctg gcg gga  gtt ttc atc ttc atc  cgc acc ttc        3294
Ile Leu  Met Gly Leu Ala Gly  Val Phe Ile Phe Ile  Arg Thr Phe            
    1085                 1090                 1095                        

tac cgt  gtt gag ctg aat acc  gat ggc aat gtt gtt  aag gag gac        3339
Tyr Arg  Val Glu Leu Asn Thr  Asp Gly Asn Val Val  Lys Glu Asp            
    1100                 1105                 1110                        

aag ctg  ccg ctg ttg ttc tgg  cgc agg atg aag ggc  caa tct gga        3384
Lys Leu  Pro Leu Leu Phe Trp  Arg Arg Met Lys Gly  Gln Ser Gly            
    1115                 1120                 1125                        

ggt gat  ggc cag atg gac cgg  gaa gaa tca gat gtc  gcc gcc gtg        3429
Gly Asp  Gly Gln Met Asp Arg  Glu Glu Ser Asp Val  Ala Ala Val            
    1130                 1135                 1140                        

gca ggc  gaa atg gcc att gca  gga gcc ccc gag aaa  cgc cgc acg        3474
Ala Gly  Glu Met Ala Ile Ala  Gly Ala Pro Glu Lys  Arg Arg Thr            
    1145                 1150                 1155                        

gtc ttg  atc gcc acc atg gag  tac gat att gcg gat  tgg cag gcc        3519
Val Leu  Ile Ala Thr Met Glu  Tyr Asp Ile Ala Asp  Trp Gln Ala            
    1160                 1165                 1170                        

aag gtc  aag att ggt ggt ctg  gga gtc atg gcc cag  ctc atg tcc        3564
Lys Val  Lys Ile Gly Gly Leu  Gly Val Met Ala Gln  Leu Met Ser            
    1175                 1180                 1185                        

caa aac  ctg gga tat cag aat  ctt atc tgg gtg gtt  ccc tgc gtg        3609
Gln Asn  Leu Gly Tyr Gln Asn  Leu Ile Trp Val Val  Pro Cys Val            
    1190                 1195                 1200                        

gga gac  atc gaa tat ccc gag  gat acc ccg aca gag  cca tac atc        3654
Gly Asp  Ile Glu Tyr Pro Glu  Asp Thr Pro Thr Glu  Pro Tyr Ile            
    1205                 1210                 1215                        

gtg aag  atc ctc gac aac ccc  tat ctc gtc aat gtg  cag tat cac        3699
Val Lys  Ile Leu Asp Asn Pro  Tyr Leu Val Asn Val  Gln Tyr His            
    1220                 1225                 1230                        

gtt ctc  aac aat atc acc tac  gtc ctt ctt gac gct  cct gtg ttc        3744
Val Leu  Asn Asn Ile Thr Tyr  Val Leu Leu Asp Ala  Pro Val Phe            
    1235                 1240                 1245                        

cgc cag  cag aca aaa gcc gag  ccg tat cct ccc cgc  atg gat gac        3789
Arg Gln  Gln Thr Lys Ala Glu  Pro Tyr Pro Pro Arg  Met Asp Asp            
    1250                 1255                 1260                        

ctg gat  agc gcc att tac tac  tcc gcc tgg aac caa  tgt atc gca        3834
Leu Asp  Ser Ala Ile Tyr Tyr  Ser Ala Trp Asn Gln  Cys Ile Ala            
    1265                 1270                 1275                        

gag acc  atc aag cgc ttc ccg  tcc atc gat ctg tat  cac atc aac        3879
Glu Thr  Ile Lys Arg Phe Pro  Ser Ile Asp Leu Tyr  His Ile Asn            
    1280                 1285                 1290                        

gat ttc  cac gga tgc ctg gca  ccg ttg tac ctc ctg  ccc aca cgc        3924
Asp Phe  His Gly Cys Leu Ala  Pro Leu Tyr Leu Leu  Pro Thr Arg            
    1295                 1300                 1305                        

acg atc  ccc gtg tgt ttg tct  ctc cac aac gcc gag  ttc cag ggt        3969
Thr Ile  Pro Val Cys Leu Ser  Leu His Asn Ala Glu  Phe Gln Gly            
    1310                 1315                 1320                        

ctc tgg  ccc ctc cgg acc cag  caa gaa aag aag gaa  gtc tgt tcg        4014
Leu Trp  Pro Leu Arg Thr Gln  Gln Glu Lys Lys Glu  Val Cys Ser            
    1325                 1330                 1335                        

gtc ttc  aac ctc ccc gtc gag  acg gct acc aaa tat  tgt caa ttc        4059
Val Phe  Asn Leu Pro Val Glu  Thr Ala Thr Lys Tyr  Cys Gln Phe            
    1340                 1345                 1350                        

ggt aat  gtg ttc aac ttg ctt  cac aca gga gcg agt  tac ctt cgg        4104
Gly Asn  Val Phe Asn Leu Leu  His Thr Gly Ala Ser  Tyr Leu Arg            
    1355                 1360                 1365                        

ttc cat  cag cgc ggg ttt ggc  gcg gtc ggt gtg tca  aag aag tac        4149
Phe His  Gln Arg Gly Phe Gly  Ala Val Gly Val Ser  Lys Lys Tyr            
    1370                 1375                 1380                        

gga aag  cgt tcc tgg gct cgg  tat cct att ttc tgg  agt ttg gac        4194
Gly Lys  Arg Ser Trp Ala Arg  Tyr Pro Ile Phe Trp  Ser Leu Asp            
    1385                 1390                 1395                        

aag atc  ggt agt ctg ccc aac  cct gac cca act gat  acg gcg gcc        4239
Lys Ile  Gly Ser Leu Pro Asn  Pro Asp Pro Thr Asp  Thr Ala Ala            
    1400                 1405                 1410                        

ctg gag  gat act cct gac gag  aaa gct ctg act cgg  tca tat gag        4284
Leu Glu  Asp Thr Pro Asp Glu  Lys Ala Leu Thr Arg  Ser Tyr Glu            
    1415                 1420                 1425                        

gaa cgg  atc act gac aag ctc  gag gcc cag aag tgg  gct ggc ctg        4329
Glu Arg  Ile Thr Asp Lys Leu  Glu Ala Gln Lys Trp  Ala Gly Leu            
    1430                 1435                 1440                        

acc gag  gat cgc aac gcc gac  ctc ctg gtg ttc gtc  ggt cgc tgg        4374
Thr Glu  Asp Arg Asn Ala Asp  Leu Leu Val Phe Val  Gly Arg Trp            
    1445                 1450                 1455                        

tct aag  cag aag ggt gtc gat  ctg att gcg gat gtc  atc ccc gcc        4419
Ser Lys  Gln Lys Gly Val Asp  Leu Ile Ala Asp Val  Ile Pro Ala            
    1460                 1465                 1470                        

gtt ctg  tct gac cgg ccg cag  gtg cag gtg atc tgt  gtt ggt ccc        4464
Val Leu  Ser Asp Arg Pro Gln  Val Gln Val Ile Cys  Val Gly Pro            
    1475                 1480                 1485                        

atc atc  gat ctt tac gga aga  ctg gct gcc att aag  ctg gag aag        4509
Ile Ile  Asp Leu Tyr Gly Arg  Leu Ala Ala Ile Lys  Leu Glu Lys            
    1490                 1495                 1500                        

atc gct  gcc atg ttc cct ggc  cgg gtc ttc tcc cga  cct gag ttc        4554
Ile Ala  Ala Met Phe Pro Gly  Arg Val Phe Ser Arg  Pro Glu Phe            
    1505                 1510                 1515                        

act gct  ttg ccc ccg tgt gtc  ttc tct ggc gct gac  ttc gct ctg        4599
Thr Ala  Leu Pro Pro Cys Val  Phe Ser Gly Ala Asp  Phe Ala Leu            
    1520                 1525                 1530                        

atc ccg  tct cgt gat gag cca  ttt gga ttg att gcc  gtt gag ttc        4644
Ile Pro  Ser Arg Asp Glu Pro  Phe Gly Leu Ile Ala  Val Glu Phe            
    1535                 1540                 1545                        

ggt cgg  aag ggt gca ctg gga  atc gga tct cgc atc  gga ggt ttg        4689
Gly Arg  Lys Gly Ala Leu Gly  Ile Gly Ser Arg Ile  Gly Gly Leu            
    1550                 1555                 1560                        

ggt cag  atg cca ggc tgg tgg  tac acc gtt gaa tca  gac gcc act        4734
Gly Gln  Met Pro Gly Trp Trp  Tyr Thr Val Glu Ser  Asp Ala Thr            
    1565                 1570                 1575                        

cgc cat  ctt cta cac cag ctg  aag act gcg atc aaa  tct gcc ctg        4779
Arg His  Leu Leu His Gln Leu  Lys Thr Ala Ile Lys  Ser Ala Leu            
    1580                 1585                 1590                        

gat tcg  act cct gaa act cga  gcc cag atg cgc gca  aac tcc gct        4824
Asp Ser  Thr Pro Glu Thr Arg  Ala Gln Met Arg Ala  Asn Ser Ala            
    1595                 1600                 1605                        

aag cag  cga ttc ccc gtt ctc  gag tgg atc cag aaa  ctc gag act        4869
Lys Gln  Arg Phe Pro Val Leu  Glu Trp Ile Gln Lys  Leu Glu Thr            
    1610                 1615                 1620                        

ttg cag  cgg aca tcg atc aag  att cat cat gac aag  aac aag gac        4914
Leu Gln  Arg Thr Ser Ile Lys  Ile His His Asp Lys  Asn Lys Asp            
    1625                 1630                 1635                        

acc gtg  act ggt tcg atc ccg  gag tct gag agc gta  tgg gac ctg        4959
Thr Val  Thr Gly Ser Ile Pro  Glu Ser Glu Ser Val  Trp Asp Leu            
    1640                 1645                 1650                        

caa aac  ctt cag agt gcg cgc  tat tcc agt gtg gca  ctt cct aat        5004
Gln Asn  Leu Gln Ser Ala Arg  Tyr Ser Ser Val Ala  Leu Pro Asn            
    1655                 1660                 1665                        

atg gct  ctg tcc aga gcg gac  ggc acg gaa acc ccg  cct gaa gcc        5049
Met Ala  Leu Ser Arg Ala Asp  Gly Thr Glu Thr Pro  Pro Glu Ala            
    1670                 1675                 1680                        

atg atc  cag cag gcc cac gct  cgc ctt caa gag atc  cag gca tcc        5094
Met Ile  Gln Gln Ala His Ala  Arg Leu Gln Glu Ile  Gln Ala Ser            
    1685                 1690                 1695                        

gag gga  agc agt cgc gac agc  agc ctc aac cgc aaa  ctg tca ctg        5139
Glu Gly  Ser Ser Arg Asp Ser  Ser Leu Asn Arg Lys  Leu Ser Leu            
    1700                 1705                 1710                        

ggt cgc  cgg tcc ggc cct ggt  cag ggc aga aag cgc  ttg acg aag        5184
Gly Arg  Arg Ser Gly Pro Gly  Gln Gly Arg Lys Arg  Leu Thr Lys            
    1715                 1720                 1725                        

agg caa  gcg acc gca agc cag  gca tcc act gat cac  gga gaa gat        5229
Arg Gln  Ala Thr Ala Ser Gln  Ala Ser Thr Asp His  Gly Glu Asp            
    1730                 1735                 1740                        

gag aac  gat acc gac gct gac  gac gac cac acc agg  ccg cag gag        5274
Glu Asn  Asp Thr Asp Ala Asp  Asp Asp His Thr Arg  Pro Gln Glu            
    1745                 1750                 1755                        

gat tac  att tct ccc gag gag  gcc atg cag gcc gtt  aac aac act        5319
Asp Tyr  Ile Ser Pro Glu Glu  Ala Met Gln Ala Val  Asn Asn Thr            
    1760                 1765                 1770                        

cta act  ccc cat gct atc act  gga gac agt act ccc  cgc gcc tcc        5364
Leu Thr  Pro His Ala Ile Thr  Gly Asp Ser Thr Pro  Arg Ala Ser            
    1775                 1780                 1785                        

tac ttg  tct aga ccc gta tcc  ccg tac ccc atc tca  cag atc tct        5409
Tyr Leu  Ser Arg Pro Val Ser  Pro Tyr Pro Ile Ser  Gln Ile Ser            
    1790                 1795                 1800                        

act cca  gcg tgc ccg aca ccg  cca ccc atg act cac  ttc cgg acc        5454
Thr Pro  Ala Cys Pro Thr Pro  Pro Pro Met Thr His  Phe Arg Thr            
    1805                 1810                 1815                        

gtt tct  atg ctg tcg ttg cca  tcc gtt gtt ggg gac  cat aac cgc        5499
Val Ser  Met Leu Ser Leu Pro  Ser Val Val Gly Asp  His Asn Arg            
    1820                 1825                 1830                        

ctc agc  agt ctc ggc ggc gag  gag cag aac cag ccc  gtc ttc gag        5544
Leu Ser  Ser Leu Gly Gly Glu  Glu Gln Asn Gln Pro  Val Phe Glu            
    1835                 1840                 1845                        

ttg cag  aag gtg gac ccg act  ttc acg gac agc ttg  ggc cac ttc        5589
Leu Gln  Lys Val Asp Pro Thr  Phe Thr Asp Ser Leu  Gly His Phe            
    1850                 1855                 1860                        

acc cgg  cgc ttc gag cag tcg  ctt gag aag ttg aac  aag aag aac        5634
Thr Arg  Arg Phe Glu Gln Ser  Leu Glu Lys Leu Asn  Lys Lys Asn            
    1865                 1870                 1875                        

tcc atc  acg gac tat tgc att  gag gtc tat ctg atg  aag agt gag        5679
Ser Ile  Thr Asp Tyr Cys Ile  Glu Val Tyr Leu Met  Lys Ser Glu            
    1880                 1885                 1890                        

cgc aag  ttc tac aat tca tac  aac gac gcc cag ctt  aag aag cag        5724
Arg Lys  Phe Tyr Asn Ser Tyr  Asn Asp Ala Gln Leu  Lys Lys Gln            
    1895                 1900                 1905                        

cct aag  aac cgt tcg ctc gcg  gtt ccc agc tct gag  agt gtt gtg        5769
Pro Lys  Asn Arg Ser Leu Ala  Val Pro Ser Ser Glu  Ser Val Val            
    1910                 1915                 1920                        

caa gaa  ggg ccc ggt ggc tca  gtc gtt cgt cac tcg  tac tcc agt        5814
Gln Glu  Gly Pro Gly Gly Ser  Val Val Arg His Ser  Tyr Ser Ser            
    1925                 1930                 1935                        

gag gat  tct gaa atc aat ggg  gag gat gag att gac  cgc tgg ctg        5859
Glu Asp  Ser Glu Ile Asn Gly  Glu Asp Glu Ile Asp  Arg Trp Leu            
    1940                 1945                 1950                        

atg cgg  ttg ggt tac acg cgt  ccg atc gca gtt cag  cga ttc atg        5904
Met Arg  Leu Gly Tyr Thr Arg  Pro Ile Ala Val Gln  Arg Phe Met            
    1955                 1960                 1965                        

aga cgc  cgc ttg ggc aat tgg  cca gtg tat tca cta  ttc ctg ggt        5949
Arg Arg  Arg Leu Gly Asn Trp  Pro Val Tyr Ser Leu  Phe Leu Gly            
    1970                 1975                 1980                        

ctg ggt  cag atc atc gcc acc  aac tcc gca caa atc  acc ctg ctt        5994
Leu Gly  Gln Ile Ile Ala Thr  Asn Ser Ala Gln Ile  Thr Leu Leu            
    1985                 1990                 1995                        

gtc ggc  cag gtc gga gag acc  gct gtg aag ctt tat  gtc atc gcc        6039
Val Gly  Gln Val Gly Glu Thr  Ala Val Lys Leu Tyr  Val Ile Ala            
    2000                 2005                 2010                        

gct atc  tac tgc ctg tcc tcc  atc gcg tgg tgg ttc  ctg tat cat        6084
Ala Ile  Tyr Cys Leu Ser Ser  Ile Ala Trp Trp Phe  Leu Tyr His            
    2015                 2020                 2025                        

cgg ttc  cca gcc gtc atc tcc  ctc agt ctt ccc tgg  ttc atc tac        6129
Arg Phe  Pro Ala Val Ile Ser  Leu Ser Leu Pro Trp  Phe Ile Tyr            
    2030                 2035                 2040                        

tgc atg  gca ttc atc gtt atc  ggt gtt tca ccc ttc  ggt ctc acg        6174
Cys Met  Ala Phe Ile Val Ile  Gly Val Ser Pro Phe  Gly Leu Thr            
    2045                 2050                 2055                        

gct ctc  ggt cgg gcc tgg gct  cag aat gtt gcg gct  ggc gtc tac        6219
Ala Leu  Gly Arg Ala Trp Ala  Gln Asn Val Ala Ala  Gly Val Tyr            
    2060                 2065                 2070                        

gcc att  gcg tcg tct agc ggt  tcc ttg ttc ttc gct  ctg aac ttt        6264
Ala Ile  Ala Ser Ser Ser Gly  Ser Leu Phe Phe Ala  Leu Asn Phe            
    2075                 2080                 2085                        

gga gac  cag ggt gcc gtc cct  gtc aag gac tgg atg  ttc cgc gcc        6309
Gly Asp  Gln Gly Ala Val Pro  Val Lys Asp Trp Met  Phe Arg Ala            
    2090                 2095                 2100                        

agt atc  att caa ggt atc tca  cag atc tac acg gtc  gcg ctc tgg        6354
Ser Ile  Ile Gln Gly Ile Ser  Gln Ile Tyr Thr Val  Ala Leu Trp            
    2105                 2110                 2115                        

ttc tgg  agc tcc aag gtc act  gcc gcc gaa gtg gga  ggt gta tct        6399
Phe Trp  Ser Ser Lys Val Thr  Ala Ala Glu Val Gly  Gly Val Ser            
    2120                 2125                 2130                        

gta gcg  gcc ttg agc tcc tgg  cgt ctc acg gcc gtg  gtg atg ccc        6444
Val Ala  Ala Leu Ser Ser Trp  Arg Leu Thr Ala Val  Val Met Pro            
    2135                 2140                 2145                        

att gct  gcc ctg tgc ttc gtg  atc gga gtc ctg ctg  gcc ctg gga        6489
Ile Ala  Ala Leu Cys Phe Val  Ile Gly Val Leu Leu  Ala Leu Gly            
    2150                 2155                 2160                        

ttg ccc  aac tac tac cgt caa  gct ccc agc cgt atc  ctg ttc ttc        6534
Leu Pro  Asn Tyr Tyr Arg Gln  Ala Pro Ser Arg Ile  Leu Phe Phe            
    2165                 2170                 2175                        

tac aag  tct ctg ttc cgc cga  cgc atc atc ctg tgg  ttc ttc ttc        6579
Tyr Lys  Ser Leu Phe Arg Arg  Arg Ile Ile Leu Trp  Phe Phe Phe            
    2180                 2185                 2190                        

atg gtc  atc gtc cag aac tgg  ttc ctt gct gcc gct  ttc ggc cgc        6624
Met Val  Ile Val Gln Asn Trp  Phe Leu Ala Ala Ala  Phe Gly Arg            
    2195                 2200                 2205                        

aac tgg  tcc ttc ctc tgg tcg  tcc aaa cac acc aag  ccc tgg gag        6669
Asn Trp  Ser Phe Leu Trp Ser  Ser Lys His Thr Lys  Pro Trp Glu            
    2210                 2215                 2220                        

att gtc  ctc ctt gtg ttc ggc  ttc ttc gtc gtc cta  tgg gta gtc        6714
Ile Val  Leu Leu Val Phe Gly  Phe Phe Val Val Leu  Trp Val Val            
    2225                 2230                 2235                        

att ctt  gtc ata ttc cgt gcc  ctg tcg aag gaa cac  agc tgg atc        6759
Ile Leu  Val Ile Phe Arg Ala  Leu Ser Lys Glu His  Ser Trp Ile            
    2240                 2245                 2250                        

ttg cca  gtt ttc ggt ctg agt  ctg ggt gct ccc cgg  tgg gca caa        6804
Leu Pro  Val Phe Gly Leu Ser  Leu Gly Ala Pro Arg  Trp Ala Gln            
    2255                 2260                 2265                        

acc tgg  tgg gga acc tcc aac  atc ggc tac tat ctc  cct tgg gct        6849
Thr Trp  Trp Gly Thr Ser Asn  Ile Gly Tyr Tyr Leu  Pro Trp Ala            
    2270                 2275                 2280                        

ggc agc  ttg gtg tcg ggg tcg  atc gct tcc cgc tgc  ctg tgg ctc        6894
Gly Ser  Leu Val Ser Gly Ser  Ile Ala Ser Arg Cys  Leu Trp Leu            
    2285                 2290                 2295                        

tgg ctg  gga ctc ctt gac gag  atc caa caa gtc gga  ttg ggt atg        6939
Trp Leu  Gly Leu Leu Asp Glu  Ile Gln Gln Val Gly  Leu Gly Met            
    2300                 2305                 2310                        

att ctg  ctg cag acc atg act  cgc gtg cat gtc tgc  ttc gtc ctg        6984
Ile Leu  Leu Gln Thr Met Thr  Arg Val His Val Cys  Phe Val Leu            
    2315                 2320                 2325                        

ttg gcc  gcg caa gca ctg gga  tcc atc gcc acc atc  tgc gcc cgc        7029
Leu Ala  Ala Gln Ala Leu Gly  Ser Ile Ala Thr Ile  Cys Ala Arg            
    2330                 2335                 2340                        

ggc ttc  gcg ccg aac aag att  ggc cct ggg gat atc  tct ccg gat        7074
Gly Phe  Ala Pro Asn Lys Ile  Gly Pro Gly Asp Ile  Ser Pro Asp            
    2345                 2350                 2355                        

gtg ggc  acg tcg gtg gac aag  gtc ggt aac gca tgg  ttc tgg atc        7119
Val Gly  Thr Ser Val Asp Lys  Val Gly Asn Ala Trp  Phe Trp Ile            
    2360                 2365                 2370                        

gct ctc  ttc ttc cag ctc ctg  gca agt tgg ggc ttc  ctg ctc ttc        7164
Ala Leu  Phe Phe Gln Leu Leu  Ala Ser Trp Gly Phe  Leu Leu Phe            
    2375                 2380                 2385                        

tac cgc  cgc gaa cag ctc aac  cga ccc taa                             7194
Tyr Arg  Arg Glu Gln Leu Asn  Arg Pro                                     
    2390                 2395                                             


<210>  3
<211>  2397
<212>  PRT
<213>  aspergillus niger

<400>  3

Met Phe Gly Thr Thr Val Gln Arg Cys Val Val Leu Ile Leu Gly Ile 
1               5                   10                  15      


Leu Ser Val Thr Thr Val Gly Trp Pro Tyr Asp Glu Ser Leu Val Asp 
            20                  25                  30          


Tyr Asn Leu Asn Glu Asn Lys Thr Ala Glu Gly Pro Ile Asn Tyr Trp 
        35                  40                  45              


Gly Glu Trp Pro Asp His Thr Tyr His Pro Ser Pro Asp Asn Trp Arg 
    50                  55                  60                  


Phe Pro Ile Tyr Thr Ile Phe Leu Asp Arg Ile Ala Asn Gly Asp Pro 
65                  70                  75                  80  


Ala Asn Asp Asp Ile Asn Gly Thr Thr Tyr Glu His Val Leu Asp Ser 
                85                  90                  95      


Asn Gln Met Arg His Gly Gly Asp Leu Val Gly Leu Ile Asp Thr Leu 
            100                 105                 110         


Asp Tyr Ile Arg Gly Met Gly Phe Lys Gly Ile Tyr Phe Ala Gly Thr 
        115                 120                 125             


Gly Leu Met Asn Leu Pro Trp Gly Tyr Asp Gly Tyr Ser Pro Val Asp 
    130                 135                 140                 


Thr Thr Leu Leu Asp Lys His His Gly Thr Leu Ser Asp Trp Arg Arg 
145                 150                 155                 160 


Thr Ile Lys Glu Ile His Asp Arg Asp Met Tyr Val Ile Met Asp Asn 
                165                 170                 175     


Thr Leu Ala Thr Leu Ser Asn Leu Ile Gly Phe Lys Gly His Leu Asn 
            180                 185                 190         


Asp Ser Ala Asp Phe Asn Ala Lys Glu Tyr Glu Val Glu Tyr Val Thr 
        195                 200                 205             


Glu Arg Thr Tyr Ala Asp Phe Gln Phe Ser Asn Asp Tyr Asn Asp Thr 
    210                 215                 220                 


Cys Asn Tyr Pro Lys Phe Trp Asn Glu Thr Gly Tyr Pro Leu Thr Ser 
225                 230                 235                 240 


Gly Gly Val Gln Asp Leu Lys Gly Cys Tyr Asn Ser Asp Phe Asp Gln 
                245                 250                 255     


Tyr Gly Glu Leu Glu Ala Phe Gly Asn Phe Pro Asp Trp Lys Arg Gln 
            260                 265                 270         


Leu Thr Lys Phe Ala Ser Val Gln Asp Arg Leu Arg Glu Trp His Lys 
        275                 280                 285             


Pro Val Arg Asp Val Ile Thr Arg His Ser Cys Ile Val Ile Ala Ser 
    290                 295                 300                 


Leu Asp Ile Asp Gly Phe Arg Phe Asp Lys Ala Val Gln Ala Thr Leu 
305                 310                 315                 320 


Asp Pro Leu Gly Asp Met Leu Ala Val Tyr Arg Glu Cys Ala Lys Gln 
                325                 330                 335     


Tyr Gly Lys Lys Asn Phe Phe Leu Pro Gly Glu Ile Thr Ser Gly Asn 
            340                 345                 350         


Thr Phe Gly Ser Leu Tyr Leu Gly Arg Gly Arg Gln Pro Asn Gln Thr 
        355                 360                 365             


Pro Asp Ser Ala Asp Ala Gly Ala Lys Leu Thr Asn Ala Ser Ser Asp 
    370                 375                 380                 


Ser Tyr Phe Leu Arg Asp Asp Gly Leu Gln Ala Leu Asp Ala Ala Ala 
385                 390                 395                 400 


Phe His Tyr Thr Ile Tyr Arg Ser Met Thr Arg Phe Leu Gly Met Asp 
                405                 410                 415     


Gly Asn Leu Val Ala Gly Phe Asp Leu Pro Thr Asp Phe Ile Glu Ala 
            420                 425                 430         


Trp Asn Gly Met Leu Val Thr Asn Asp Phe Ile Asn Ala Phe Thr Gly 
        435                 440                 445             


Glu Leu Asp Pro Arg His Met Tyr Gly Val Ser Asn Gln Asp Asn Phe 
    450                 455                 460                 


Arg Trp Pro Ala Ile Lys Asn Gly Thr Glu Lys Tyr Leu Leu Gly Leu 
465                 470                 475                 480 


Tyr Ile Val Thr Leu Glu Leu Pro Gly Ile Pro Leu Val Leu Trp Gly 
                485                 490                 495     


Glu Glu Gln Glu Met Tyr Val Phe Asp Ala Thr Ala Ser Asn Tyr Leu 
            500                 505                 510         


Phe Gly Arg Gln Pro Met Thr Tyr Gln Thr Ala Trp Trp Thr His Gly 
        515                 520                 525             


Cys Phe Ser Leu Asn Thr Ser Lys Phe Tyr Asp Phe Pro Asn Asp Lys 
    530                 535                 540                 


Gly Leu Asn Gly Cys Asn Asp Ile Thr Val Thr Tyr Asp Gln Arg Asn 
545                 550                 555                 560 


Pro Ala His Pro Leu Arg Asn Ile Met Lys Arg Met Phe Glu Ile Arg 
                565                 570                 575     


Glu Gln Tyr Pro Val Ala Asn Asp Gly Phe Asn Leu Glu Thr Ile Ser 
            580                 585                 590         


Gln Leu Thr Gln Asp Ile Tyr Leu Pro Gly Ser Ser Thr Thr Pro Thr 
        595                 600                 605             


Val Thr Gly Leu Trp Ser Val Leu Arg Ser Tyr Tyr Pro Gly Val Gln 
    610                 615                 620                 


Lys Glu Ala Ser Ser Ser Asn Asp Thr Leu Trp Leu Val Tyr His Asn 
625                 630                 635                 640 


Ala Asn Lys Thr Glu Thr Tyr Gly Lys Asn Cys Thr Ser Lys Asp Ser 
                645                 650                 655     


Ala Leu Leu Ser Pro Tyr Glu Ser Gly Thr Lys Leu Lys Asn Leu Phe 
            660                 665                 670         


Tyr Pro Tyr Asp Glu Leu Thr Leu Gln Asp Gly Pro Ser Asp Ala Ser 
        675                 680                 685             


Asn Gly Thr Glu Ser Tyr Gly Cys Thr Thr Asn Met Lys Leu Leu Pro 
    690                 695                 700                 


Trp Glu Phe Arg Ala Tyr Val Lys Ala Ser Asp Phe Val Glu Pro Gly 
705                 710                 715                 720 


Pro Thr Val Thr Glu Phe Val Pro Gly His Asp Ala Arg Leu Leu Ser 
                725                 730                 735     


Ser Glu Asp Thr Gly Glu Thr Leu Lys Ile Gln Leu Gly Tyr Ser Lys 
            740                 745                 750         


Ala Met Asp Cys Ser Ala Ile Thr Lys Ala Val Ser Leu Asn Ser Thr 
        755                 760                 765             


Thr Val Lys Gly Val Asn Ala Thr Leu Asp Thr Ser Ser Val Ser Cys 
    770                 775                 780                 


Thr Asn Val Thr Ala Arg Thr Ser Ser Asn Asn Tyr Ile Gly Glu Val 
785                 790                 795                 800 


Pro Thr Val Trp Thr Trp Ser Ala Asn Leu Thr Asn Val Tyr His Gly 
                805                 810                 815     


Ile His Gln Leu Thr Val Lys Asn Ala Ser Thr Thr Ser Gly Thr Arg 
            820                 825                 830         


Val Asp Ala Ile Asp Arg Phe Leu Phe Arg Val Gly Thr His Thr Asn 
        835                 840                 845             


Pro Leu Ile Ser Pro Leu Ala Asn Tyr Ser Thr Ser Leu Val His Gln 
    850                 855                 860                 


Ser Asp Asn Gly Ser Tyr Tyr Val Gln His Asp Ala Ala Gly Ala Asp 
865                 870                 875                 880 


Gln Phe Arg Tyr Thr Thr Asp Phe Gly Leu Asn Trp Ser Asn Trp Thr 
                885                 890                 895     


Asp Tyr Thr Gly Gly Asn Thr Thr Ile Glu Phe Pro Thr Trp Thr Gly 
            900                 905                 910         


Thr Asp Ala Gln Lys Trp Glu Gly Thr His Ile Arg Val Gln Tyr Phe 
        915                 920                 925             


Ser Arg Leu Thr Gly Ser Ser Asp Tyr Ile Gln Glu Gly Asp Tyr Asp 
    930                 935                 940                 


Trp Glu Ser Gly Val Pro Arg Arg Phe Pro His Leu Trp Trp Asn Gly 
945                 950                 955                 960 


Pro Tyr Asn Gln Tyr Gly Tyr Asp Ala Gly Leu Asp Ser Lys Met Arg 
                965                 970                 975     


Phe Asp Thr Lys Asp Arg Arg Trp Lys Tyr Asp Phe Val Tyr Glu Trp 
            980                 985                 990         


Pro Ser Val Gly Gln Ile Ser Val  Trp Gly Thr Gly Lys  Asp Gly Val 
        995                 1000                 1005             


Pro Glu  Thr Thr Asn Val Tyr  Gly Asp Val Asp Asn  Ser Ser Val 
    1010                 1015                 1020             


Val Gln  Val Leu Pro Pro Ser  Tyr Leu Ser Ser Asn  Val Ile Asn 
    1025                 1030                 1035             


Ile Thr  Glu Leu Pro Pro Phe  Pro His Leu Gly Trp  Thr Ile Ser 
    1040                 1045                 1050             


Leu Asn  Asp Ala Asn Leu Arg  Tyr Glu Leu Leu Pro  Val Gly Ser 
    1055                 1060                 1065             


Gly Trp  Ala Gln Leu Val Leu  Tyr Ile Leu Leu Trp  Val Val Pro 
    1070                 1075                 1080             


Ile Leu  Met Gly Leu Ala Gly  Val Phe Ile Phe Ile  Arg Thr Phe 
    1085                 1090                 1095             


Tyr Arg  Val Glu Leu Asn Thr  Asp Gly Asn Val Val  Lys Glu Asp 
    1100                 1105                 1110             


Lys Leu  Pro Leu Leu Phe Trp  Arg Arg Met Lys Gly  Gln Ser Gly 
    1115                 1120                 1125             


Gly Asp  Gly Gln Met Asp Arg  Glu Glu Ser Asp Val  Ala Ala Val 
    1130                 1135                 1140             


Ala Gly  Glu Met Ala Ile Ala  Gly Ala Pro Glu Lys  Arg Arg Thr 
    1145                 1150                 1155             


Val Leu  Ile Ala Thr Met Glu  Tyr Asp Ile Ala Asp  Trp Gln Ala 
    1160                 1165                 1170             


Lys Val  Lys Ile Gly Gly Leu  Gly Val Met Ala Gln  Leu Met Ser 
    1175                 1180                 1185             


Gln Asn  Leu Gly Tyr Gln Asn  Leu Ile Trp Val Val  Pro Cys Val 
    1190                 1195                 1200             


Gly Asp  Ile Glu Tyr Pro Glu  Asp Thr Pro Thr Glu  Pro Tyr Ile 
    1205                 1210                 1215             


Val Lys  Ile Leu Asp Asn Pro  Tyr Leu Val Asn Val  Gln Tyr His 
    1220                 1225                 1230             


Val Leu  Asn Asn Ile Thr Tyr  Val Leu Leu Asp Ala  Pro Val Phe 
    1235                 1240                 1245             


Arg Gln  Gln Thr Lys Ala Glu  Pro Tyr Pro Pro Arg  Met Asp Asp 
    1250                 1255                 1260             


Leu Asp  Ser Ala Ile Tyr Tyr  Ser Ala Trp Asn Gln  Cys Ile Ala 
    1265                 1270                 1275             


Glu Thr  Ile Lys Arg Phe Pro  Ser Ile Asp Leu Tyr  His Ile Asn 
    1280                 1285                 1290             


Asp Phe  His Gly Cys Leu Ala  Pro Leu Tyr Leu Leu  Pro Thr Arg 
    1295                 1300                 1305             


Thr Ile  Pro Val Cys Leu Ser  Leu His Asn Ala Glu  Phe Gln Gly 
    1310                 1315                 1320             


Leu Trp  Pro Leu Arg Thr Gln  Gln Glu Lys Lys Glu  Val Cys Ser 
    1325                 1330                 1335             


Val Phe  Asn Leu Pro Val Glu  Thr Ala Thr Lys Tyr  Cys Gln Phe 
    1340                 1345                 1350             


Gly Asn  Val Phe Asn Leu Leu  His Thr Gly Ala Ser  Tyr Leu Arg 
    1355                 1360                 1365             


Phe His  Gln Arg Gly Phe Gly  Ala Val Gly Val Ser  Lys Lys Tyr 
    1370                 1375                 1380             


Gly Lys  Arg Ser Trp Ala Arg  Tyr Pro Ile Phe Trp  Ser Leu Asp 
    1385                 1390                 1395             


Lys Ile  Gly Ser Leu Pro Asn  Pro Asp Pro Thr Asp  Thr Ala Ala 
    1400                 1405                 1410             


Leu Glu  Asp Thr Pro Asp Glu  Lys Ala Leu Thr Arg  Ser Tyr Glu 
    1415                 1420                 1425             


Glu Arg  Ile Thr Asp Lys Leu  Glu Ala Gln Lys Trp  Ala Gly Leu 
    1430                 1435                 1440             


Thr Glu  Asp Arg Asn Ala Asp  Leu Leu Val Phe Val  Gly Arg Trp 
    1445                 1450                 1455             


Ser Lys  Gln Lys Gly Val Asp  Leu Ile Ala Asp Val  Ile Pro Ala 
    1460                 1465                 1470             


Val Leu  Ser Asp Arg Pro Gln  Val Gln Val Ile Cys  Val Gly Pro 
    1475                 1480                 1485             


Ile Ile  Asp Leu Tyr Gly Arg  Leu Ala Ala Ile Lys  Leu Glu Lys 
    1490                 1495                 1500             


Ile Ala  Ala Met Phe Pro Gly  Arg Val Phe Ser Arg  Pro Glu Phe 
    1505                 1510                 1515             


Thr Ala  Leu Pro Pro Cys Val  Phe Ser Gly Ala Asp  Phe Ala Leu 
    1520                 1525                 1530             


Ile Pro  Ser Arg Asp Glu Pro  Phe Gly Leu Ile Ala  Val Glu Phe 
    1535                 1540                 1545             


Gly Arg  Lys Gly Ala Leu Gly  Ile Gly Ser Arg Ile  Gly Gly Leu 
    1550                 1555                 1560             


Gly Gln  Met Pro Gly Trp Trp  Tyr Thr Val Glu Ser  Asp Ala Thr 
    1565                 1570                 1575             


Arg His  Leu Leu His Gln Leu  Lys Thr Ala Ile Lys  Ser Ala Leu 
    1580                 1585                 1590             


Asp Ser  Thr Pro Glu Thr Arg  Ala Gln Met Arg Ala  Asn Ser Ala 
    1595                 1600                 1605             


Lys Gln  Arg Phe Pro Val Leu  Glu Trp Ile Gln Lys  Leu Glu Thr 
    1610                 1615                 1620             


Leu Gln  Arg Thr Ser Ile Lys  Ile His His Asp Lys  Asn Lys Asp 
    1625                 1630                 1635             


Thr Val  Thr Gly Ser Ile Pro  Glu Ser Glu Ser Val  Trp Asp Leu 
    1640                 1645                 1650             


Gln Asn  Leu Gln Ser Ala Arg  Tyr Ser Ser Val Ala  Leu Pro Asn 
    1655                 1660                 1665             


Met Ala  Leu Ser Arg Ala Asp  Gly Thr Glu Thr Pro  Pro Glu Ala 
    1670                 1675                 1680             


Met Ile  Gln Gln Ala His Ala  Arg Leu Gln Glu Ile  Gln Ala Ser 
    1685                 1690                 1695             


Glu Gly  Ser Ser Arg Asp Ser  Ser Leu Asn Arg Lys  Leu Ser Leu 
    1700                 1705                 1710             


Gly Arg  Arg Ser Gly Pro Gly  Gln Gly Arg Lys Arg  Leu Thr Lys 
    1715                 1720                 1725             


Arg Gln  Ala Thr Ala Ser Gln  Ala Ser Thr Asp His  Gly Glu Asp 
    1730                 1735                 1740             


Glu Asn  Asp Thr Asp Ala Asp  Asp Asp His Thr Arg  Pro Gln Glu 
    1745                 1750                 1755             


Asp Tyr  Ile Ser Pro Glu Glu  Ala Met Gln Ala Val  Asn Asn Thr 
    1760                 1765                 1770             


Leu Thr  Pro His Ala Ile Thr  Gly Asp Ser Thr Pro  Arg Ala Ser 
    1775                 1780                 1785             


Tyr Leu  Ser Arg Pro Val Ser  Pro Tyr Pro Ile Ser  Gln Ile Ser 
    1790                 1795                 1800             


Thr Pro  Ala Cys Pro Thr Pro  Pro Pro Met Thr His  Phe Arg Thr 
    1805                 1810                 1815             


Val Ser  Met Leu Ser Leu Pro  Ser Val Val Gly Asp  His Asn Arg 
    1820                 1825                 1830             


Leu Ser  Ser Leu Gly Gly Glu  Glu Gln Asn Gln Pro  Val Phe Glu 
    1835                 1840                 1845             


Leu Gln  Lys Val Asp Pro Thr  Phe Thr Asp Ser Leu  Gly His Phe 
    1850                 1855                 1860             


Thr Arg  Arg Phe Glu Gln Ser  Leu Glu Lys Leu Asn  Lys Lys Asn 
    1865                 1870                 1875             


Ser Ile  Thr Asp Tyr Cys Ile  Glu Val Tyr Leu Met  Lys Ser Glu 
    1880                 1885                 1890             


Arg Lys  Phe Tyr Asn Ser Tyr  Asn Asp Ala Gln Leu  Lys Lys Gln 
    1895                 1900                 1905             


Pro Lys  Asn Arg Ser Leu Ala  Val Pro Ser Ser Glu  Ser Val Val 
    1910                 1915                 1920             


Gln Glu  Gly Pro Gly Gly Ser  Val Val Arg His Ser  Tyr Ser Ser 
    1925                 1930                 1935             


Glu Asp  Ser Glu Ile Asn Gly  Glu Asp Glu Ile Asp  Arg Trp Leu 
    1940                 1945                 1950             


Met Arg  Leu Gly Tyr Thr Arg  Pro Ile Ala Val Gln  Arg Phe Met 
    1955                 1960                 1965             


Arg Arg  Arg Leu Gly Asn Trp  Pro Val Tyr Ser Leu  Phe Leu Gly 
    1970                 1975                 1980             


Leu Gly  Gln Ile Ile Ala Thr  Asn Ser Ala Gln Ile  Thr Leu Leu 
    1985                 1990                 1995             


Val Gly  Gln Val Gly Glu Thr  Ala Val Lys Leu Tyr  Val Ile Ala 
    2000                 2005                 2010             


Ala Ile  Tyr Cys Leu Ser Ser  Ile Ala Trp Trp Phe  Leu Tyr His 
    2015                 2020                 2025             


Arg Phe  Pro Ala Val Ile Ser  Leu Ser Leu Pro Trp  Phe Ile Tyr 
    2030                 2035                 2040             


Cys Met  Ala Phe Ile Val Ile  Gly Val Ser Pro Phe  Gly Leu Thr 
    2045                 2050                 2055             


Ala Leu  Gly Arg Ala Trp Ala  Gln Asn Val Ala Ala  Gly Val Tyr 
    2060                 2065                 2070             


Ala Ile  Ala Ser Ser Ser Gly  Ser Leu Phe Phe Ala  Leu Asn Phe 
    2075                 2080                 2085             


Gly Asp  Gln Gly Ala Val Pro  Val Lys Asp Trp Met  Phe Arg Ala 
    2090                 2095                 2100             


Ser Ile  Ile Gln Gly Ile Ser  Gln Ile Tyr Thr Val  Ala Leu Trp 
    2105                 2110                 2115             


Phe Trp  Ser Ser Lys Val Thr  Ala Ala Glu Val Gly  Gly Val Ser 
    2120                 2125                 2130             


Val Ala  Ala Leu Ser Ser Trp  Arg Leu Thr Ala Val  Val Met Pro 
    2135                 2140                 2145             


Ile Ala  Ala Leu Cys Phe Val  Ile Gly Val Leu Leu  Ala Leu Gly 
    2150                 2155                 2160             


Leu Pro  Asn Tyr Tyr Arg Gln  Ala Pro Ser Arg Ile  Leu Phe Phe 
    2165                 2170                 2175             


Tyr Lys  Ser Leu Phe Arg Arg  Arg Ile Ile Leu Trp  Phe Phe Phe 
    2180                 2185                 2190             


Met Val  Ile Val Gln Asn Trp  Phe Leu Ala Ala Ala  Phe Gly Arg 
    2195                 2200                 2205             


Asn Trp  Ser Phe Leu Trp Ser  Ser Lys His Thr Lys  Pro Trp Glu 
    2210                 2215                 2220             


Ile Val  Leu Leu Val Phe Gly  Phe Phe Val Val Leu  Trp Val Val 
    2225                 2230                 2235             


Ile Leu  Val Ile Phe Arg Ala  Leu Ser Lys Glu His  Ser Trp Ile 
    2240                 2245                 2250             


Leu Pro  Val Phe Gly Leu Ser  Leu Gly Ala Pro Arg  Trp Ala Gln 
    2255                 2260                 2265             


Thr Trp  Trp Gly Thr Ser Asn  Ile Gly Tyr Tyr Leu  Pro Trp Ala 
    2270                 2275                 2280             


Gly Ser  Leu Val Ser Gly Ser  Ile Ala Ser Arg Cys  Leu Trp Leu 
    2285                 2290                 2295             


Trp Leu  Gly Leu Leu Asp Glu  Ile Gln Gln Val Gly  Leu Gly Met 
    2300                 2305                 2310             


Ile Leu  Leu Gln Thr Met Thr  Arg Val His Val Cys  Phe Val Leu 
    2315                 2320                 2325             


Leu Ala  Ala Gln Ala Leu Gly  Ser Ile Ala Thr Ile  Cys Ala Arg 
    2330                 2335                 2340             


Gly Phe  Ala Pro Asn Lys Ile  Gly Pro Gly Asp Ile  Ser Pro Asp 
    2345                 2350                 2355             


Val Gly  Thr Ser Val Asp Lys  Val Gly Asn Ala Trp  Phe Trp Ile 
    2360                 2365                 2370             


Ala Leu  Phe Phe Gln Leu Leu  Ala Ser Trp Gly Phe  Leu Leu Phe 
    2375                 2380                 2385             


Tyr Arg  Arg Glu Gln Leu Asn  Arg Pro 
    2390                 2395         


<210>  4
<211>  7532
<212>  DNA
<213>  aspergillus niger

<400>  4
atgaagtggg ctatttccgg cacgctgctc gcctgtttcg caacaactgc aacggcctgg       60

ccttacgacg agtccctcgt cgactacaac ttcaatcaga accagtccgc tacgaacccg      120

gcggactatt ggggaacatg gcccaatcat accggggact acttcccctc cccggacaat      180

tggcgcttcc ccgtctacac cctctttctc gaccgcttcg tcaacggtga ccccacaaac      240

gacaacatca atggcaccct gttcgaacat gacctccgct cgaatcagat gcgccatggt      300

ggcgatgttg ccggcctgct ggataccttg gattacttgc agggcatggg aatcaaggtc      360

ggtccctgtg gcttgtccga tgctgcgatc aattactgac gatggtttag ggtctctatc      420

ttgccggaac aatcctcatg aaccagccct ggggatctga cggttattcg gctttggaca      480

cgacattgtt ggatcaacac tatggtaacc tgcagacgtg gcgcaatgcc atcacggaaa      540

ttcacaagcg cgggatgtat gtcatcttcg ataacaccat cgcaacgtaa gtttgccgct      600

gccttttccc ctctttccta cccaacaaac taacctgcaa tttttaggat gggtgatttg      660

atcggatttg atggctatct gaacaccacc acccccttct ccgtgaagga acaccaaacg      720

gtgtggaaga ctgaccgccg ctatgtggac ttcgacattg gcaatgacta caacgagacg      780

tgcgactacc cccgcttctg gttcgaggat ggctaccccg ttcaagcgtc agtcaccgag      840

gagcttgtcg gatgttacaa cagtgatttc gaccagtacg gtgatattga ggcctttggt      900

gtcttccccg attggcaacg tcagctggca aaattcgcct ccgttcagga tcgactccgt      960

gaatgggttc cctccgtgcg cgagcgtttg atccgccact cctgcatcat tattcagtcg     1020

ctcgatattg acggtttccg gtacgacaag gcgactcagg caaccgtcga cgccctcgga     1080

gatatgtcca atgcgtaccg cgagtgcgcc cgcgccgtag gaaaagagaa cttcttcatt     1140

gcgggcgaaa tcacgggtgg taataccttt ggttccatct acttgggccg aggaagacag     1200

cccaaccagt tccctgactc ggcggaggca gccatgaagc tgaccaacac ttccgacgcc     1260

cagtatttcc tgcgtgaagt gggacatgag gcgattgatg gtgcagcctt ccactactcc     1320

atttaccgag cgctgacccg cttcctgggc atggatggta acttggctgc cggttacgat     1380

gtgccagtcg actgggttga tgcctggaat ctcatgctgc agtccaacga tctggtcaat     1440

gcgaatacag gcaagttcga cccccgccac atgtacgggg ctaccaacca ggatgtcttc     1500

cgttggccca cggtggaaaa gggcgtggag cgtcagttgc ttggattgta catcacgact     1560

cttctgctcc ccggaattcc gctccttctc tggggcgagg aacaggcgtt ttacgtactg     1620

gatgccacgg catcgaacta catctacggt cggcaggcca tgtctcctgc caccgcatgg     1680

agggatcatg gctgtttctc cttggaatcg tctcagtact ataattggcc cattgagtcc     1740

ggccgtcagg gctgccacga ccccacggtg gcctacgatc atcgtgaccc gtctcatccc     1800

gtgcgcaata tcattaagca tatgtatcag atgcgcgaac agttccccgt cctcaatgac     1860

ggctatacta ttcaaaagct ctcgaaccac accgaggacg tgtactatct cggttccaac     1920

ggcacagcca ccgagaccgg actctggtcg attcttcgtg atgtgaacgc ggatgtgcag     1980

gatttgggct ccgatgcgaa gaaccagcct gtctggctgg tttaccacaa cacgaaccgc     2040

accattgatt acaagtttga ctgctcggat aatgatacag ctctgattgc ccccttcgat     2100

agtggcacct gggtcaaaaa cctgttccac ccgtatgacg agcaccagct gatcgattcc     2160

cccaccaagt tgggattgaa cggatcaact gcatacagtg gctgcttggc taatatgacc     2220

atgtccgcct atgaattccg ggcctacgtg cctaaaaccc gctttactaa acccaggccg     2280

atgattacaa agttcactcc gggacacgat gtcccgatcc gctcgaccgt ggccccgaac     2340

gcagacgaga acgtggaggt cgaaatttac ttctccgaag aaatggattg cgactcggtg     2400

acaaagtcca ttaccctttc gtcatcgacc gaaattggaa aggccccctc tgtcgattct     2460

ggcagtgtca actgcaagtc agtccccgcc actaacacca gctggaccgg ccagattccc     2520

ggggtgtgga tgtgggcggc caacctgaca ggtgtgtaca acggcattca tcgtctcaca     2580

gtcaacaatg tcagcacaga gagtgggaac gcaaccacca acgccgtcga ccatttcctc     2640

ttccgcatcg gccagattga taatccgatg attttcagca gtgcgaacta ttcaactagt     2700

ttgctccata aggaatccaa cggcaccctt ttcatccagc accacgccgc gggtgctgat     2760

aagtatcgct attctacgaa ttggggtacc actttctccg attggattga ctacaggggc     2820

ggaaatgaca ctattgagga actcgaatgg tcgggaacca agaagcagtc atggaaagga     2880

aaccacgttc gcgtggagta ttggagtcgt tggaccggca gcagcgatta cgtccaagag     2940

ggagacgcgg gctggaacga gaatgttcca cgccgtttcc ctcacgtctt cttcaacgga     3000

ccctacaacc agtatgggta tgatgcaggt ctggacaacg tggtccgcca ggacagcgtt     3060

gacggtctct ggaaatatca tttcaccgcg gaatggcctg ctcaagctca attgaacatt     3120

tggggtatga accctgatgg ggagcctgac cagagttggg tcctgggaga tgccgataat     3180

gattcggttc tcgatcgcat gccgccctct tcgctgtccg cgacattgat taacatcact     3240

gaacaccccc cctctcccta catttcgtgg aatatcttca ttgatgacgg gaccatgcgc     3300

ttccagctgt tccccgtcgg gcatcagaat actcagatcg ccatgtatgt gctcttttgg     3360

atcatccccg tcatcacggg cgcagccggt gtgtgggctt tcatgaagtc tttctacaag     3420

gtcaaattca accaggttgg tgtgagcgaa aaacaccaga tgatcccatt ggccttgcgg     3480

cggaagttca agcgcaatcg caatcgtggc ggtgatgagg aaaactcaaa ccctctcatg     3540

cgtctggcga acaagtccgg gttcctccag actgacacgg cgattggtgg tgctgctagc     3600

ggcaagcgtc gcatggtcct gatcgccacc atggagtacg acattgagga ttgggccatc     3660

aagatcaaga ttggtggtct tggtgtcatg gcgcaactca tgggtaagac tctgggtcat     3720

caagacttga tctgggtggt gccttgcgtt gggggtgtcg attaccccgt ggacaaaccc     3780

gcagagccca tgcatgtcac cattcttggc aattcgtacg aggtccaggt ccagtatcac     3840

gtcttgaata acatcaccta tgttctgctg gatgcccctg tgttccgtca acagtctaag     3900

tcagagcctt acccggctcg catggacgac ctgaacagcg ccatttacta ctcggcctgg     3960

aatcagtgca ttgcggaagc ctgcaagaga ttccctatcg acctgtatca tatcaacgac     4020

taccatggtt ccctggctcc actgtatcta cttcctgaca cagtacctgc ctgtctttcc     4080

ctgcataacg ccgagttcca aggtttgtgg cccatgcgga cgcagaaaga aaaggaggaa     4140

gtttgctccg tgttcaatct ggatatcgag accgtgaggc attacgtgca gtttggagag     4200

gtgttcaact tgctccactc gggtgctagt tatctccgtg ttcaccaaca aggtttcggt     4260

gctgttggtg tgtctaagaa gtacggaaag cggtcctacg cgcgttaccc cattttctgg     4320

ggtctccgca aggttggaaa cctacctaac cctgatccgt ctgatgtcgg tgagtggagc     4380

aaggaacagg ccagcgccat gggtgacaat gtgagcgtgg acccgactta tgaagccggt     4440

cgaggcgacc tcaagcgtca agctcaggag tgggccggtc ttgaacagaa ccctgacgcc     4500

gatttgcttg tcttcgttgg tcgttggtcg atgcagaagg gtgttgattt gatcgccgac     4560

gtcatgcctg ctgtcctgga agcacgcccc aatgttcagc tcatttgtgt tggaccagtt     4620

atcgatctct acggtaaatt cgcggccctc aaactcgatc acatgatgaa ggtctacccc     4680

ggacgagtgt tctctagacc tgagttcacg gcattgcccc cctacatctt ctctggtgct     4740

gaattcgcgc tgattccctc tcgtgacgag cccttcggtc tggtcgccgt cgagttcgga     4800

cgtaagggag ctctgggtat cggtgcccgg gttggtggtc tcggtcagat gccaggttgg     4860

tggtacaatg tggaatcgac agctacctcc catttgctcg ttcagttcaa gctggctatc     4920

gacgcggctc tcagttcgaa aacggaaact cgtgctatga tgcgtgcccg gtccgccaaa     4980

cagcgcttcc cggtcgccca gtgggtggaa gacttggaga tcctgcaaac caccgccatc     5040

caagtgcaca acaaggaatt ggttaaacat aacggtcgac ccttcacccc gtctggaact     5100

accacgccgg gtggcatctt aagccagccg tcaagtccac taatgccccc tggaatgcag     5160

actcccttgg ctcattctcg ggaaagcagc tattctaacc tgaaccgtct cagtgaatat     5220

gtcacagatc cgaaaacaaa ctacagtcga gacatcagcc ccagtgggac ggaaaagccg     5280

cggtccggcc tgcaacgaca gctttctctt ggtgttcgct caggacctgg tcatcaagag     5340

cgccgtggcc gtcgtggacg ccagcgcgac agcatccccg aacacgaaga caccgcaggg     5400

gccatgaccg acgtcgaaga agaccacgag gacattgggg atcagcagga tgcggacgac     5460

gagtacactc tcaccccggc tcaggtcgag gaaggacgtc gcttgcaggc tgtccagcag     5520

cagggagtgg gtatgccgac gagtccgggc gtccgccgtt atagtcaaga ctccttgcat     5580

ccgcgacagc ttcctagcag ccctggcccc gtcccacctc ctacacagag cctccttccg     5640

ccacccaggc ttggggatgc cggtagccga ctcagtagcg cgtctgtcct gtccctggat     5700

tcggtcgttg gtaccaagac ggacttcaag ctccagaagg ttgacccctt ctttacggat     5760

tctactggcg agtactacaa ggcattcgac aagaggctgg tcggcttgaa cggctcgaac     5820

tccgaatccc agctttgcat tgaggaatat ctcatcaaga gtgagaagga atggttcgac     5880

aagttccgcg atgcccgact gggtcgtcta aaatcccccg cgtcgtctgt cttccgggac     5940

aagcatggtg cctcccctgt tggctcctac tacgatgata cgggctcccg ggtgagtggt     6000

gactatgacc gggagtcccg cgacacggaa gatgacgagt tcctcctggg caaggactac     6060

gtgcctccga cgggtctgcg caagtggatg cagattcgtg ttggagactg gccagtctac     6120

tcgttattcc ttgccttggg tcagatcatt gcagccaact cttatcaggt gaccttgctt     6180

accggtgagg ttggtgagac ggccgagaag ctctatggta tcgcaaccac ctacctgatc     6240

acctcgatcc tttggtggct tgtgttccgt tacttcaaat cggtggtgtg cctctcggct     6300

ccctggttct tctatggcct tgccttcctt ctgatcggct ccgctcactt tgaacccaat     6360

tcattcaacc ggggttggat ccagaacatc ggaagtggat gttacgccgc tgcctcgtct     6420

agcggttcca tcttcttcgc cttgaacttt ggtgacgaag gtggtgcgcc ggtcgaaacc     6480

tggatcttcc gggcttgtct cattcagggt atccagtcgg cttatatcat cggactgtgg     6540

tattggggtt ccactctgac caaggcatcc agccagggtc tgttgacctc gacgaacaac     6600

atcgccaata gctggaagat gacgtgagta cattgaaccc tctgattgtt catcaatcag     6660

ccagtcattc catcttgtga cccgctaaca ctgatctcct ctagtgccat ctgttacccg     6720

attgcaatct tcctctgggc tgttggattg ctgcttctct ttggacttcc taactactat     6780

cgccaaaccc cgggcaaagt ggcctccttt tacaagtccg tattccgccg caagatcgtc     6840

ctctggaact tcgttgccgt catcctgcaa aacttcttcc tcagcgcacc gtacggccgc     6900

aactggggct gtaagtctaa ctttccctgc cacatcgtgt cgaattgata agctaactct     6960

agtccgcagt cctttggtct tccaatcacg ccaaggcctg gcaaatcgtt attctctgta     7020

tcgtcttcta cgggttcgtc tgggcgggct tcctgttcgt cgtcagccgc tatttcaagt     7080

cccacagctg gttcctgccc gtgtttgcgt gcggacttgg agcacctcgc ttcattcaaa     7140

tctggtgggg tgtctcgggc atcggttact tccttccctg ggtctccgga ggctatctcg     7200

gcggagcttt ggcctcgagg agtctctggc tctggctggg cgtgttggat tccatccagg     7260

gtctcgggtt cggtatcatc ctcctgcaga ccctcacccg catgcacatg ctgttcaccc     7320

tgatctgctc gcaggtgctt ggttccattg ccaccatctg tgcgcgggcg tttgccccga     7380

ataacgtcgg gcccggccct gtgtcgccgg accctacctt tggaggaagt gcagtggcca     7440

atgcgtggtt ctgggtggcc ctgttttgtc agctgttggt gtgtgctggc ttcctcctct     7500

tcttccggaa agagcagctt tccaaacctt ga                                   7532


<210>  5
<211>  7278
<212>  DNA
<213>  aspergillus niger


<220>
<221>  CDS
<222>  (1)..(7275)
<223>  AgsE-encoding cDNA

<400>  5
atg aag tgg gct att tcc ggc acg ctg ctc gcc tgt ttc gca aca act         48
Met Lys Trp Ala Ile Ser Gly Thr Leu Leu Ala Cys Phe Ala Thr Thr           
1               5                   10                  15                

gca acg gcc tgg cct tac gac gag tcc ctc gtc gac tac aac ttc aat         96
Ala Thr Ala Trp Pro Tyr Asp Glu Ser Leu Val Asp Tyr Asn Phe Asn           
            20                  25                  30                    

cag aac cag tcc gct acg aac ccg gcg gac tat tgg gga aca tgg ccc        144
Gln Asn Gln Ser Ala Thr Asn Pro Ala Asp Tyr Trp Gly Thr Trp Pro           
        35                  40                  45                        

aat cat acc ggg gac tac ttc ccc tcc ccg gac aat tgg cgc ttc ccc        192
Asn His Thr Gly Asp Tyr Phe Pro Ser Pro Asp Asn Trp Arg Phe Pro           
    50                  55                  60                            

gtc tac acc ctc ttt ctc gac cgc ttc gtc aac ggt gac ccc aca aac        240
Val Tyr Thr Leu Phe Leu Asp Arg Phe Val Asn Gly Asp Pro Thr Asn           
65                  70                  75                  80            

gac aac atc aat ggc acc ctg ttc gaa cat gac ctc cgc tcg aat cag        288
Asp Asn Ile Asn Gly Thr Leu Phe Glu His Asp Leu Arg Ser Asn Gln           
                85                  90                  95                

atg cgc cat ggt ggc gat gtt gcc ggc ctg ctg gat acc ttg gat tac        336
Met Arg His Gly Gly Asp Val Ala Gly Leu Leu Asp Thr Leu Asp Tyr           
            100                 105                 110                   

ttg cag ggc atg gga atc aag ggt ctc tat ctt gcc gga aca atc ctc        384
Leu Gln Gly Met Gly Ile Lys Gly Leu Tyr Leu Ala Gly Thr Ile Leu           
        115                 120                 125                       

atg aac cag ccc tgg gga tct gac ggt tat tcg gct ttg gac acg aca        432
Met Asn Gln Pro Trp Gly Ser Asp Gly Tyr Ser Ala Leu Asp Thr Thr           
    130                 135                 140                           

ttg ttg gat caa cac tat ggt aac ctg cag acg tgg cgc aat gcc atc        480
Leu Leu Asp Gln His Tyr Gly Asn Leu Gln Thr Trp Arg Asn Ala Ile           
145                 150                 155                 160           

acg gaa att cac aag cgc ggg atg tat gtc atc ttc gat aac acc atc        528
Thr Glu Ile His Lys Arg Gly Met Tyr Val Ile Phe Asp Asn Thr Ile           
                165                 170                 175               

gca acg atg ggt gat ttg atc gga ttt gat ggc tat ctg aac acc acc        576
Ala Thr Met Gly Asp Leu Ile Gly Phe Asp Gly Tyr Leu Asn Thr Thr           
            180                 185                 190                   

acc ccc ttc tcc gtg aag gaa cac caa acg gtg tgg aag act gac cgc        624
Thr Pro Phe Ser Val Lys Glu His Gln Thr Val Trp Lys Thr Asp Arg           
        195                 200                 205                       

cgc tat gtg gac ttc gac att ggc aat gac tac aac gag acg tgc gac        672
Arg Tyr Val Asp Phe Asp Ile Gly Asn Asp Tyr Asn Glu Thr Cys Asp           
    210                 215                 220                           

tac ccc cgc ttc tgg ttc gag gat ggc tac ccc gtt caa gcg tca gtc        720
Tyr Pro Arg Phe Trp Phe Glu Asp Gly Tyr Pro Val Gln Ala Ser Val           
225                 230                 235                 240           

acc gag gag ctt gtc gga tgt tac aac agt gat ttc gac cag tac ggt        768
Thr Glu Glu Leu Val Gly Cys Tyr Asn Ser Asp Phe Asp Gln Tyr Gly           
                245                 250                 255               

gat att gag gcc ttt ggt gtc ttc ccc gat tgg caa cgt cag ctg gca        816
Asp Ile Glu Ala Phe Gly Val Phe Pro Asp Trp Gln Arg Gln Leu Ala           
            260                 265                 270                   

aaa ttc gcc tcc gtt cag gat cga ctc cgt gaa tgg gtt ccc tcc gtg        864
Lys Phe Ala Ser Val Gln Asp Arg Leu Arg Glu Trp Val Pro Ser Val           
        275                 280                 285                       

cgc gag cgt ttg atc cgc cac tcc tgc atc att att cag tcg ctc gat        912
Arg Glu Arg Leu Ile Arg His Ser Cys Ile Ile Ile Gln Ser Leu Asp           
    290                 295                 300                           

att gac ggt ttc cgg tac gac aag gcg act cag gca acc gtc gac gcc        960
Ile Asp Gly Phe Arg Tyr Asp Lys Ala Thr Gln Ala Thr Val Asp Ala           
305                 310                 315                 320           

ctc gga gat atg tcc aat gcg tac cgc gag tgc gcc cgc gcc gta gga       1008
Leu Gly Asp Met Ser Asn Ala Tyr Arg Glu Cys Ala Arg Ala Val Gly           
                325                 330                 335               

aaa gag aac ttc ttc att gcg ggc gaa atc acg ggt ggt aat acc ttt       1056
Lys Glu Asn Phe Phe Ile Ala Gly Glu Ile Thr Gly Gly Asn Thr Phe           
            340                 345                 350                   

ggt tcc atc tac ttg ggc cga gga aga cag ccc aac cag ttc cct gac       1104
Gly Ser Ile Tyr Leu Gly Arg Gly Arg Gln Pro Asn Gln Phe Pro Asp           
        355                 360                 365                       

tcg gcg gag gca gcc atg aag ctg acc aac act tcc gac gcc cag tat       1152
Ser Ala Glu Ala Ala Met Lys Leu Thr Asn Thr Ser Asp Ala Gln Tyr           
    370                 375                 380                           

ttc ctg cgt gaa gtg gga cat gag gcg att gat ggt gca gcc ttc cac       1200
Phe Leu Arg Glu Val Gly His Glu Ala Ile Asp Gly Ala Ala Phe His           
385                 390                 395                 400           

tac tcc att tac cga gcg ctg acc cgc ttc ctg ggc atg gat ggt aac       1248
Tyr Ser Ile Tyr Arg Ala Leu Thr Arg Phe Leu Gly Met Asp Gly Asn           
                405                 410                 415               

ttg gct gcc ggt tac gat gtg cca gtc gac tgg gtt gat gcc tgg aat       1296
Leu Ala Ala Gly Tyr Asp Val Pro Val Asp Trp Val Asp Ala Trp Asn           
            420                 425                 430                   

ctc atg ctg cag tcc aac gat ctg gtc aat gcg aat aca ggc aag ttc       1344
Leu Met Leu Gln Ser Asn Asp Leu Val Asn Ala Asn Thr Gly Lys Phe           
        435                 440                 445                       

gac ccc cgc cac atg tac ggg gct acc aac cag gat gtc ttc cgt tgg       1392
Asp Pro Arg His Met Tyr Gly Ala Thr Asn Gln Asp Val Phe Arg Trp           
    450                 455                 460                           

ccc acg gtg gaa aag ggc gtg gag cgt cag ttg ctt gga ttg tac atc       1440
Pro Thr Val Glu Lys Gly Val Glu Arg Gln Leu Leu Gly Leu Tyr Ile           
465                 470                 475                 480           

acg act ctt ctg ctc ccc gga att ccg ctc ctt ctc tgg ggc gag gaa       1488
Thr Thr Leu Leu Leu Pro Gly Ile Pro Leu Leu Leu Trp Gly Glu Glu           
                485                 490                 495               

cag gcg ttt tac gta ctg gat gcc acg gca tcg aac tac atc tac ggt       1536
Gln Ala Phe Tyr Val Leu Asp Ala Thr Ala Ser Asn Tyr Ile Tyr Gly           
            500                 505                 510                   

cgg cag gcc atg tct cct gcc acc gca tgg agg gat cat ggc tgt ttc       1584
Arg Gln Ala Met Ser Pro Ala Thr Ala Trp Arg Asp His Gly Cys Phe           
        515                 520                 525                       

tcc ttg gaa tcg tct cag tac tat aat tgg ccc att gag tcc ggc cgt       1632
Ser Leu Glu Ser Ser Gln Tyr Tyr Asn Trp Pro Ile Glu Ser Gly Arg           
    530                 535                 540                           

cag ggc tgc cac gac ccc acg gtg gcc tac gat cat cgt gac ccg tct       1680
Gln Gly Cys His Asp Pro Thr Val Ala Tyr Asp His Arg Asp Pro Ser           
545                 550                 555                 560           

cat ccc gtg cgc aat atc att aag cat atg tat cag atg cgc gaa cag       1728
His Pro Val Arg Asn Ile Ile Lys His Met Tyr Gln Met Arg Glu Gln           
                565                 570                 575               

ttc ccc gtc ctc aat gac ggc tat act att caa aag ctc tcg aac cac       1776
Phe Pro Val Leu Asn Asp Gly Tyr Thr Ile Gln Lys Leu Ser Asn His           
            580                 585                 590                   

acc gag gac gtg tac tat ctc ggt tcc aac ggc aca gcc acc gag acc       1824
Thr Glu Asp Val Tyr Tyr Leu Gly Ser Asn Gly Thr Ala Thr Glu Thr           
        595                 600                 605                       

gga ctc tgg tcg att ctt cgt gat gtg aac gcg gat gtg cag gat ttg       1872
Gly Leu Trp Ser Ile Leu Arg Asp Val Asn Ala Asp Val Gln Asp Leu           
    610                 615                 620                           

ggc tcc gat gcg aag aac cag cct gtc tgg ctg gtt tac cac aac acg       1920
Gly Ser Asp Ala Lys Asn Gln Pro Val Trp Leu Val Tyr His Asn Thr           
625                 630                 635                 640           

aac cgc acc att gat tac aag ttt gac tgc tcg gat aat gat aca gct       1968
Asn Arg Thr Ile Asp Tyr Lys Phe Asp Cys Ser Asp Asn Asp Thr Ala           
                645                 650                 655               

ctg att gcc ccc ttc gat agt ggc acc tgg gtc aaa aac ctg ttc cac       2016
Leu Ile Ala Pro Phe Asp Ser Gly Thr Trp Val Lys Asn Leu Phe His           
            660                 665                 670                   

ccg tat gac gag cac cag ctg atc gat tcc ccc acc aag ttg gga ttg       2064
Pro Tyr Asp Glu His Gln Leu Ile Asp Ser Pro Thr Lys Leu Gly Leu           
        675                 680                 685                       

aac gga tca act gca tac agt ggc tgc ttg gct aat atg acc atg tcc       2112
Asn Gly Ser Thr Ala Tyr Ser Gly Cys Leu Ala Asn Met Thr Met Ser           
    690                 695                 700                           

gcc tat gaa ttc cgg gcc tac gtg cct aaa acc cgc ttt act aaa ccc       2160
Ala Tyr Glu Phe Arg Ala Tyr Val Pro Lys Thr Arg Phe Thr Lys Pro           
705                 710                 715                 720           

agg ccg atg att aca aag ttc act ccg gga cac gat gtc ccg atc cgc       2208
Arg Pro Met Ile Thr Lys Phe Thr Pro Gly His Asp Val Pro Ile Arg           
                725                 730                 735               

tcg acc gtg gcc ccg aac gca gac gag aac gtg gag gtc gaa att tac       2256
Ser Thr Val Ala Pro Asn Ala Asp Glu Asn Val Glu Val Glu Ile Tyr           
            740                 745                 750                   

ttc tcc gaa gaa atg gat tgc gac tcg gtg aca aag tcc att acc ctt       2304
Phe Ser Glu Glu Met Asp Cys Asp Ser Val Thr Lys Ser Ile Thr Leu           
        755                 760                 765                       

tcg tca tcg acc gaa att gga aag gcc ccc tct gtc gat tct ggc agt       2352
Ser Ser Ser Thr Glu Ile Gly Lys Ala Pro Ser Val Asp Ser Gly Ser           
    770                 775                 780                           

gtc aac tgc aag tca gtc ccc gcc act aac acc agc tgg acc ggc cag       2400
Val Asn Cys Lys Ser Val Pro Ala Thr Asn Thr Ser Trp Thr Gly Gln           
785                 790                 795                 800           

att ccc ggg gtg tgg atg tgg gcg gcc aac ctg aca ggt gtg tac aac       2448
Ile Pro Gly Val Trp Met Trp Ala Ala Asn Leu Thr Gly Val Tyr Asn           
                805                 810                 815               

ggc att cat cgt ctc aca gtc aac aat gtc agc aca gag agt ggg aac       2496
Gly Ile His Arg Leu Thr Val Asn Asn Val Ser Thr Glu Ser Gly Asn           
            820                 825                 830                   

gca acc acc aac gcc gtc gac cat ttc ctc ttc cgc atc ggc cag att       2544
Ala Thr Thr Asn Ala Val Asp His Phe Leu Phe Arg Ile Gly Gln Ile           
        835                 840                 845                       

gat aat ccg atg att ttc agc agt gcg aac tat tca act agt ttg ctc       2592
Asp Asn Pro Met Ile Phe Ser Ser Ala Asn Tyr Ser Thr Ser Leu Leu           
    850                 855                 860                           

cat aag gaa tcc aac ggc acc ctt ttc atc cag cac cac gcc gcg ggt       2640
His Lys Glu Ser Asn Gly Thr Leu Phe Ile Gln His His Ala Ala Gly           
865                 870                 875                 880           

gct gat aag tat cgc tat tct acg aat tgg ggt acc act ttc tcc gat       2688
Ala Asp Lys Tyr Arg Tyr Ser Thr Asn Trp Gly Thr Thr Phe Ser Asp           
                885                 890                 895               

tgg att gac tac agg ggc gga aat gac act att gag gaa ctc gaa tgg       2736
Trp Ile Asp Tyr Arg Gly Gly Asn Asp Thr Ile Glu Glu Leu Glu Trp           
            900                 905                 910                   

tcg gga acc aag aag cag tca tgg aaa gga aac cac gtt cgc gtg gag       2784
Ser Gly Thr Lys Lys Gln Ser Trp Lys Gly Asn His Val Arg Val Glu           
        915                 920                 925                       

tat tgg agt cgt tgg acc ggc agc agc gat tac gtc caa gag gga gac       2832
Tyr Trp Ser Arg Trp Thr Gly Ser Ser Asp Tyr Val Gln Glu Gly Asp           
    930                 935                 940                           

gcg ggc tgg aac gag aat gtt cca cgc cgt ttc cct cac gtc ttc ttc       2880
Ala Gly Trp Asn Glu Asn Val Pro Arg Arg Phe Pro His Val Phe Phe           
945                 950                 955                 960           

aac gga ccc tac aac cag tat ggg tat gat gca ggt ctg gac aac gtg       2928
Asn Gly Pro Tyr Asn Gln Tyr Gly Tyr Asp Ala Gly Leu Asp Asn Val           
                965                 970                 975               

gtc cgc cag gac agc gtt gac ggt ctc tgg aaa tat cat ttc acc gcg       2976
Val Arg Gln Asp Ser Val Asp Gly Leu Trp Lys Tyr His Phe Thr Ala           
            980                 985                 990                   

gaa tgg cct gct caa gct caa ttg  aac att tgg ggt atg  aac cct gat     3024
Glu Trp Pro Ala Gln Ala Gln Leu  Asn Ile Trp Gly Met  Asn Pro Asp         
        995                 1000                 1005                     

ggg gag  cct gac cag agt tgg  gtc ctg gga gat gcc  gat aat gat        3069
Gly Glu  Pro Asp Gln Ser Trp  Val Leu Gly Asp Ala  Asp Asn Asp            
    1010                 1015                 1020                        

tcg gtt  ctc gat cgc atg ccg  ccc tct tcg ctg tcc  gcg aca ttg        3114
Ser Val  Leu Asp Arg Met Pro  Pro Ser Ser Leu Ser  Ala Thr Leu            
    1025                 1030                 1035                        

att aac  atc act gaa cac ccc  ccc tct ccc tac att  tcg tgg aat        3159
Ile Asn  Ile Thr Glu His Pro  Pro Ser Pro Tyr Ile  Ser Trp Asn            
    1040                 1045                 1050                        

atc ttc  att gat gac ggg acc  atg cgc ttc cag ctg  ttc ccc gtc        3204
Ile Phe  Ile Asp Asp Gly Thr  Met Arg Phe Gln Leu  Phe Pro Val            
    1055                 1060                 1065                        

ggg cat  cag aat act cag atc  gcc atg tat gtg ctc  ttt tgg atc        3249
Gly His  Gln Asn Thr Gln Ile  Ala Met Tyr Val Leu  Phe Trp Ile            
    1070                 1075                 1080                        

atc ccc  gtc atc acg ggc gca  gcc ggt gtg tgg gct  ttc atg aag        3294
Ile Pro  Val Ile Thr Gly Ala  Ala Gly Val Trp Ala  Phe Met Lys            
    1085                 1090                 1095                        

tct ttc  tac aag gtc aaa ttc  aac cag gtt ggt gtg  agc gaa aaa        3339
Ser Phe  Tyr Lys Val Lys Phe  Asn Gln Val Gly Val  Ser Glu Lys            
    1100                 1105                 1110                        

cac cag  atg atc cca ttg gcc  ttg cgg cgg aag ttc  aag cgc aat        3384
His Gln  Met Ile Pro Leu Ala  Leu Arg Arg Lys Phe  Lys Arg Asn            
    1115                 1120                 1125                        

cgc aat  cgt ggc ggt gat gag  gaa aac tca aac cct  ctc atg cgt        3429
Arg Asn  Arg Gly Gly Asp Glu  Glu Asn Ser Asn Pro  Leu Met Arg            
    1130                 1135                 1140                        

ctg gcg  aac aag tcc ggg ttc  ctc cag act gac acg  gcg att ggt        3474
Leu Ala  Asn Lys Ser Gly Phe  Leu Gln Thr Asp Thr  Ala Ile Gly            
    1145                 1150                 1155                        

ggt gct  gct agc ggc aag cgt  cgc atg gtc ctg atc  gcc acc atg        3519
Gly Ala  Ala Ser Gly Lys Arg  Arg Met Val Leu Ile  Ala Thr Met            
    1160                 1165                 1170                        

gag tac  gac att gag gat tgg  gcc atc aag atc aag  att ggt ggt        3564
Glu Tyr  Asp Ile Glu Asp Trp  Ala Ile Lys Ile Lys  Ile Gly Gly            
    1175                 1180                 1185                        

ctt ggt  gtc atg gcg caa ctc  atg ggt aag act ctg  ggt cat caa        3609
Leu Gly  Val Met Ala Gln Leu  Met Gly Lys Thr Leu  Gly His Gln            
    1190                 1195                 1200                        

gac ttg  atc tgg gtg gtg cct  tgc gtt ggg ggt gtc  gat tac ccc        3654
Asp Leu  Ile Trp Val Val Pro  Cys Val Gly Gly Val  Asp Tyr Pro            
    1205                 1210                 1215                        

gtg gac  aaa ccc gca gag ccc  atg cat gtc acc att  ctt ggc aat        3699
Val Asp  Lys Pro Ala Glu Pro  Met His Val Thr Ile  Leu Gly Asn            
    1220                 1225                 1230                        

tcg tac  gag gtc cag gtc cag  tat cac gtc ttg aat  aac atc acc        3744
Ser Tyr  Glu Val Gln Val Gln  Tyr His Val Leu Asn  Asn Ile Thr            
    1235                 1240                 1245                        

tat gtt  ctg ctg gat gcc cct  gtg ttc cgt caa cag  tct aag tca        3789
Tyr Val  Leu Leu Asp Ala Pro  Val Phe Arg Gln Gln  Ser Lys Ser            
    1250                 1255                 1260                        

gag cct  tac ccg gct cgc atg  gac gac ctg aac agc  gcc att tac        3834
Glu Pro  Tyr Pro Ala Arg Met  Asp Asp Leu Asn Ser  Ala Ile Tyr            
    1265                 1270                 1275                        

tac tcg  gcc tgg aat cag tgc  att gcg gaa gcc tgc  aag aga ttc        3879
Tyr Ser  Ala Trp Asn Gln Cys  Ile Ala Glu Ala Cys  Lys Arg Phe            
    1280                 1285                 1290                        

cct atc  gac ctg tat cat atc  aac gac tac cat ggt  tcc ctg gct        3924
Pro Ile  Asp Leu Tyr His Ile  Asn Asp Tyr His Gly  Ser Leu Ala            
    1295                 1300                 1305                        

cca ctg  tat cta ctt cct gac  aca gta cct gcc tgt  ctt tcc ctg        3969
Pro Leu  Tyr Leu Leu Pro Asp  Thr Val Pro Ala Cys  Leu Ser Leu            
    1310                 1315                 1320                        

cat aac  gcc gag ttc caa ggt  ttg tgg ccc atg cgg  acg cag aaa        4014
His Asn  Ala Glu Phe Gln Gly  Leu Trp Pro Met Arg  Thr Gln Lys            
    1325                 1330                 1335                        

gaa aag  gag gaa gtt tgc tcc  gtg ttc aat ctg gat  atc gag acc        4059
Glu Lys  Glu Glu Val Cys Ser  Val Phe Asn Leu Asp  Ile Glu Thr            
    1340                 1345                 1350                        

gtg agg  cat tac gtg cag ttt  gga gag gtg ttc aac  ttg ctc cac        4104
Val Arg  His Tyr Val Gln Phe  Gly Glu Val Phe Asn  Leu Leu His            
    1355                 1360                 1365                        

tcg ggt  gct agt tat ctc cgt  gtt cac caa caa ggt  ttc ggt gct        4149
Ser Gly  Ala Ser Tyr Leu Arg  Val His Gln Gln Gly  Phe Gly Ala            
    1370                 1375                 1380                        

gtt ggt  gtg tct aag aag tac  gga aag cgg tcc tac  gcg cgt tac        4194
Val Gly  Val Ser Lys Lys Tyr  Gly Lys Arg Ser Tyr  Ala Arg Tyr            
    1385                 1390                 1395                        

ccc att  ttc tgg ggt ctc cgc  aag gtt gga aac cta  cct aac cct        4239
Pro Ile  Phe Trp Gly Leu Arg  Lys Val Gly Asn Leu  Pro Asn Pro            
    1400                 1405                 1410                        

gat ccg  tct gat gtc ggt gag  tgg agc aag gaa cag  gcc agc gcc        4284
Asp Pro  Ser Asp Val Gly Glu  Trp Ser Lys Glu Gln  Ala Ser Ala            
    1415                 1420                 1425                        

atg ggt  gac aat gtg agc gtg  gac ccg act tat gaa  gcc ggt cga        4329
Met Gly  Asp Asn Val Ser Val  Asp Pro Thr Tyr Glu  Ala Gly Arg            
    1430                 1435                 1440                        

ggc gac  ctc aag cgt caa gct  cag gag tgg gcc ggt  ctt gaa cag        4374
Gly Asp  Leu Lys Arg Gln Ala  Gln Glu Trp Ala Gly  Leu Glu Gln            
    1445                 1450                 1455                        

aac cct  gac gcc gat ttg ctt  gtc ttc gtt ggt cgt  tgg tcg atg        4419
Asn Pro  Asp Ala Asp Leu Leu  Val Phe Val Gly Arg  Trp Ser Met            
    1460                 1465                 1470                        

cag aag  ggt gtt gat ttg atc  gcc gac gtc atg cct  gct gtc ctg        4464
Gln Lys  Gly Val Asp Leu Ile  Ala Asp Val Met Pro  Ala Val Leu            
    1475                 1480                 1485                        

gaa gca  cgc ccc aat gtt cag  ctc att tgt gtt gga  cca gtt atc        4509
Glu Ala  Arg Pro Asn Val Gln  Leu Ile Cys Val Gly  Pro Val Ile            
    1490                 1495                 1500                        

gat ctc  tac ggt aaa ttc gcg  gcc ctc aaa ctc gat  cac atg atg        4554
Asp Leu  Tyr Gly Lys Phe Ala  Ala Leu Lys Leu Asp  His Met Met            
    1505                 1510                 1515                        

aag gtc  tac ccc gga cga gtg  ttc tct aga cct gag  ttc acg gca        4599
Lys Val  Tyr Pro Gly Arg Val  Phe Ser Arg Pro Glu  Phe Thr Ala            
    1520                 1525                 1530                        

ttg ccc  ccc tac atc ttc tct  ggt gct gaa ttc gcg  ctg att ccc        4644
Leu Pro  Pro Tyr Ile Phe Ser  Gly Ala Glu Phe Ala  Leu Ile Pro            
    1535                 1540                 1545                        

tct cgt  gac gag ccc ttc ggt  ctg gtc gcc gtc gag  ttc gga cgt        4689
Ser Arg  Asp Glu Pro Phe Gly  Leu Val Ala Val Glu  Phe Gly Arg            
    1550                 1555                 1560                        

aag gga  gct ctg ggt atc ggt  gcc cgg gtt ggt ggt  ctc ggt cag        4734
Lys Gly  Ala Leu Gly Ile Gly  Ala Arg Val Gly Gly  Leu Gly Gln            
    1565                 1570                 1575                        

atg cca  ggt tgg tgg tac aat  gtg gaa tcg aca gct  acc tcc cat        4779
Met Pro  Gly Trp Trp Tyr Asn  Val Glu Ser Thr Ala  Thr Ser His            
    1580                 1585                 1590                        

ttg ctc  gtt cag ttc aag ctg  gct atc gac gcg gct  ctc agt tcg        4824
Leu Leu  Val Gln Phe Lys Leu  Ala Ile Asp Ala Ala  Leu Ser Ser            
    1595                 1600                 1605                        

aaa acg  gaa act cgt gct atg  atg cgt gcc cgg tcc  gcc aaa cag        4869
Lys Thr  Glu Thr Arg Ala Met  Met Arg Ala Arg Ser  Ala Lys Gln            
    1610                 1615                 1620                        

cgc ttc  ccg gtc gcc cag tgg  gtg gaa gac ttg gag  atc ctg caa        4914
Arg Phe  Pro Val Ala Gln Trp  Val Glu Asp Leu Glu  Ile Leu Gln            
    1625                 1630                 1635                        

acc acc  gcc atc caa gtg cac  aac aag gaa ttg gtt  aaa cat aac        4959
Thr Thr  Ala Ile Gln Val His  Asn Lys Glu Leu Val  Lys His Asn            
    1640                 1645                 1650                        

ggt cga  ccc ttc acc ccg tct  gga act acc acg ccg  ggt ggc atc        5004
Gly Arg  Pro Phe Thr Pro Ser  Gly Thr Thr Thr Pro  Gly Gly Ile            
    1655                 1660                 1665                        

tta agc  cag ccg tca agt cca  cta atg ccc cct gga  atg cag act        5049
Leu Ser  Gln Pro Ser Ser Pro  Leu Met Pro Pro Gly  Met Gln Thr            
    1670                 1675                 1680                        

ccc ttg  gct cat tct cgg gaa  agc agc tat tct aac  ctg aac cgt        5094
Pro Leu  Ala His Ser Arg Glu  Ser Ser Tyr Ser Asn  Leu Asn Arg            
    1685                 1690                 1695                        

ctc agt  gaa tat gtc aca gat  ccg aaa aca aac tac  agt cga gac        5139
Leu Ser  Glu Tyr Val Thr Asp  Pro Lys Thr Asn Tyr  Ser Arg Asp            
    1700                 1705                 1710                        

atc agc  ccc agt ggg acg gaa  aag ccg cgg tcc ggc  ctg caa cga        5184
Ile Ser  Pro Ser Gly Thr Glu  Lys Pro Arg Ser Gly  Leu Gln Arg            
    1715                 1720                 1725                        

cag ctt  tct ctt ggt gtt cgc  tca gga cct ggt cat  caa gag cgc        5229
Gln Leu  Ser Leu Gly Val Arg  Ser Gly Pro Gly His  Gln Glu Arg            
    1730                 1735                 1740                        

cgt ggc  cgt cgt gga cgc cag  cgc gac agc atc ccc  gaa cac gaa        5274
Arg Gly  Arg Arg Gly Arg Gln  Arg Asp Ser Ile Pro  Glu His Glu            
    1745                 1750                 1755                        

gac acc  gca ggg gcc atg acc  gac gtc gaa gaa gac  cac gag gac        5319
Asp Thr  Ala Gly Ala Met Thr  Asp Val Glu Glu Asp  His Glu Asp            
    1760                 1765                 1770                        

att ggg  gat cag cag gat gcg  gac gac gag tac act  ctc acc ccg        5364
Ile Gly  Asp Gln Gln Asp Ala  Asp Asp Glu Tyr Thr  Leu Thr Pro            
    1775                 1780                 1785                        

gct cag  gtc gag gaa gga cgt  cgc ttg cag gct gtc  cag cag cag        5409
Ala Gln  Val Glu Glu Gly Arg  Arg Leu Gln Ala Val  Gln Gln Gln            
    1790                 1795                 1800                        

gga gtg  ggt atg ccg acg agt  ccg ggc gtc cgc cgt  tat agt caa        5454
Gly Val  Gly Met Pro Thr Ser  Pro Gly Val Arg Arg  Tyr Ser Gln            
    1805                 1810                 1815                        

gac tcc  ttg cat ccg cga cag  ctt cct agc agc cct  ggc ccc gtc        5499
Asp Ser  Leu His Pro Arg Gln  Leu Pro Ser Ser Pro  Gly Pro Val            
    1820                 1825                 1830                        

cca cct  cct aca cag agc ctc  ctt ccg cca ccc agg  ctt ggg gat        5544
Pro Pro  Pro Thr Gln Ser Leu  Leu Pro Pro Pro Arg  Leu Gly Asp            
    1835                 1840                 1845                        

gcc ggt  agc cga ctc agt agc  gcg tct gtc ctg tcc  ctg gat tcg        5589
Ala Gly  Ser Arg Leu Ser Ser  Ala Ser Val Leu Ser  Leu Asp Ser            
    1850                 1855                 1860                        

gtc gtt  ggt acc aag acg gac  ttc aag ctc cag aag  gtt gac ccc        5634
Val Val  Gly Thr Lys Thr Asp  Phe Lys Leu Gln Lys  Val Asp Pro            
    1865                 1870                 1875                        

ttc ttt  acg gat tct act ggc  gag tac tac aag gca  ttc gac aag        5679
Phe Phe  Thr Asp Ser Thr Gly  Glu Tyr Tyr Lys Ala  Phe Asp Lys            
    1880                 1885                 1890                        

agg ctg  gtc ggc ttg aac ggc  tcg aac tcc gaa tcc  cag ctt tgc        5724
Arg Leu  Val Gly Leu Asn Gly  Ser Asn Ser Glu Ser  Gln Leu Cys            
    1895                 1900                 1905                        

att gag  gaa tat ctc atc aag  agt gag aag gaa tgg  ttc gac aag        5769
Ile Glu  Glu Tyr Leu Ile Lys  Ser Glu Lys Glu Trp  Phe Asp Lys            
    1910                 1915                 1920                        

ttc cgc  gat gcc cga ctg ggt  cgt cta aaa tcc ccc  gcg tcg tct        5814
Phe Arg  Asp Ala Arg Leu Gly  Arg Leu Lys Ser Pro  Ala Ser Ser            
    1925                 1930                 1935                        

gtc ttc  cgg gac aag cat ggt  gcc tcc cct gtt ggc  tcc tac tac        5859
Val Phe  Arg Asp Lys His Gly  Ala Ser Pro Val Gly  Ser Tyr Tyr            
    1940                 1945                 1950                        

gat gat  acg ggc tcc cgg gtg  agt ggt gac tat gac  cgg gag tcc        5904
Asp Asp  Thr Gly Ser Arg Val  Ser Gly Asp Tyr Asp  Arg Glu Ser            
    1955                 1960                 1965                        

cgc gac  acg gaa gat gac gag  ttc ctc ctg ggc aag  gac tac gtg        5949
Arg Asp  Thr Glu Asp Asp Glu  Phe Leu Leu Gly Lys  Asp Tyr Val            
    1970                 1975                 1980                        

cct ccg  acg ggt ctg cgc aag  tgg atg cag att cgt  gtt gga gac        5994
Pro Pro  Thr Gly Leu Arg Lys  Trp Met Gln Ile Arg  Val Gly Asp            
    1985                 1990                 1995                        

tgg cca  gtc tac tcg tta ttc  ctt gcc ttg ggt cag  atc att gca        6039
Trp Pro  Val Tyr Ser Leu Phe  Leu Ala Leu Gly Gln  Ile Ile Ala            
    2000                 2005                 2010                        

gcc aac  tct tat cag gtg acc  ttg ctt acc ggt gag  gtt ggt gag        6084
Ala Asn  Ser Tyr Gln Val Thr  Leu Leu Thr Gly Glu  Val Gly Glu            
    2015                 2020                 2025                        

acg gcc  gag aag ctc tat ggt  atc gca acc acc tac  ctg atc acc        6129
Thr Ala  Glu Lys Leu Tyr Gly  Ile Ala Thr Thr Tyr  Leu Ile Thr            
    2030                 2035                 2040                        

tcg atc  ctt tgg tgg ctt gtg  ttc cgt tac ttc aaa  tcg gtg gtg        6174
Ser Ile  Leu Trp Trp Leu Val  Phe Arg Tyr Phe Lys  Ser Val Val            
    2045                 2050                 2055                        

tgc ctc  tcg gct ccc tgg ttc  ttc tat ggc ctt gcc  ttc ctt ctg        6219
Cys Leu  Ser Ala Pro Trp Phe  Phe Tyr Gly Leu Ala  Phe Leu Leu            
    2060                 2065                 2070                        

atc ggc  tcc gct cac ttt gaa  ccc aat tca ttc aac  cgg ggt tgg        6264
Ile Gly  Ser Ala His Phe Glu  Pro Asn Ser Phe Asn  Arg Gly Trp            
    2075                 2080                 2085                        

atc cag  aac atc gga agt gga  tgt tac gcc gct gcc  tcg tct agc        6309
Ile Gln  Asn Ile Gly Ser Gly  Cys Tyr Ala Ala Ala  Ser Ser Ser            
    2090                 2095                 2100                        

ggt tcc  atc ttc ttc gcc ttg  aac ttt ggt gac gaa  ggt ggt gcg        6354
Gly Ser  Ile Phe Phe Ala Leu  Asn Phe Gly Asp Glu  Gly Gly Ala            
    2105                 2110                 2115                        

ccg gtc  gaa acc tgg atc ttc  cgg gct tgt ctc att  cag ggt atc        6399
Pro Val  Glu Thr Trp Ile Phe  Arg Ala Cys Leu Ile  Gln Gly Ile            
    2120                 2125                 2130                        

cag tcg  gct tat atc atc gga  ctg tgg tat tgg ggt  tcc act ctg        6444
Gln Ser  Ala Tyr Ile Ile Gly  Leu Trp Tyr Trp Gly  Ser Thr Leu            
    2135                 2140                 2145                        

acc aag  gca tcc agc cag ggt  ctg ttg acc tcg acg  aac aac atc        6489
Thr Lys  Ala Ser Ser Gln Gly  Leu Leu Thr Ser Thr  Asn Asn Ile            
    2150                 2155                 2160                        

gcc aat  agc tgg aag atg act  gcc atc tgt tac ccg  att gca atc        6534
Ala Asn  Ser Trp Lys Met Thr  Ala Ile Cys Tyr Pro  Ile Ala Ile            
    2165                 2170                 2175                        

ttc ctc  tgg gct gtt gga ttg  ctg ctt ctc ttt gga  ctt cct aac        6579
Phe Leu  Trp Ala Val Gly Leu  Leu Leu Leu Phe Gly  Leu Pro Asn            
    2180                 2185                 2190                        

tac tat  cgc caa acc ccg ggc  aaa gtg gcc tcc ttt  tac aag tcc        6624
Tyr Tyr  Arg Gln Thr Pro Gly  Lys Val Ala Ser Phe  Tyr Lys Ser            
    2195                 2200                 2205                        

gta ttc  cgc cgc aag atc gtc  ctc tgg aac ttc gtt  gcc gtc atc        6669
Val Phe  Arg Arg Lys Ile Val  Leu Trp Asn Phe Val  Ala Val Ile            
    2210                 2215                 2220                        

ctg caa  aac ttc ttc ctc agc  gca ccg tac ggc cgc  aac tgg ggc        6714
Leu Gln  Asn Phe Phe Leu Ser  Ala Pro Tyr Gly Arg  Asn Trp Gly            
    2225                 2230                 2235                        

ttc ctt  tgg tct tcc aat cac  gcc aag gcc tgg caa  atc gtt att        6759
Phe Leu  Trp Ser Ser Asn His  Ala Lys Ala Trp Gln  Ile Val Ile            
    2240                 2245                 2250                        

ctc tgt  atc gtc ttc tac ggg  ttc gtc tgg gcg ggc  ttc ctg ttc        6804
Leu Cys  Ile Val Phe Tyr Gly  Phe Val Trp Ala Gly  Phe Leu Phe            
    2255                 2260                 2265                        

gtc gtc  agc cgc tat ttc aag  tcc cac agc tgg ttc  ctg ccc gtg        6849
Val Val  Ser Arg Tyr Phe Lys  Ser His Ser Trp Phe  Leu Pro Val            
    2270                 2275                 2280                        

ttt gcg  tgc gga ctt gga gca  cct cgc ttc att caa  atc tgg tgg        6894
Phe Ala  Cys Gly Leu Gly Ala  Pro Arg Phe Ile Gln  Ile Trp Trp            
    2285                 2290                 2295                        

ggt gtc  tcg ggc atc ggt tac  ttc ctt ccc tgg gtc  tcc gga ggc        6939
Gly Val  Ser Gly Ile Gly Tyr  Phe Leu Pro Trp Val  Ser Gly Gly            
    2300                 2305                 2310                        

tat ctc  ggc gga gct ttg gcc  tcg agg agt ctc tgg  ctc tgg ctg        6984
Tyr Leu  Gly Gly Ala Leu Ala  Ser Arg Ser Leu Trp  Leu Trp Leu            
    2315                 2320                 2325                        

ggc gtg  ttg gat tcc atc cag  ggt ctc ggg ttc ggt  atc atc ctc        7029
Gly Val  Leu Asp Ser Ile Gln  Gly Leu Gly Phe Gly  Ile Ile Leu            
    2330                 2335                 2340                        

ctg cag  acc ctc acc cgc atg  cac atg ctg ttc acc  ctg atc tgc        7074
Leu Gln  Thr Leu Thr Arg Met  His Met Leu Phe Thr  Leu Ile Cys            
    2345                 2350                 2355                        

tcg cag  gtg ctt ggt tcc att  gcc acc atc tgt gcg  cgg gcg ttt        7119
Ser Gln  Val Leu Gly Ser Ile  Ala Thr Ile Cys Ala  Arg Ala Phe            
    2360                 2365                 2370                        

gcc ccg  aat aac gtc ggg ccc  ggc cct gtg tcg ccg  gac cct acc        7164
Ala Pro  Asn Asn Val Gly Pro  Gly Pro Val Ser Pro  Asp Pro Thr            
    2375                 2380                 2385                        

ttt gga  gga agt gca gtg gcc  aat gcg tgg ttc tgg  gtg gcc ctg        7209
Phe Gly  Gly Ser Ala Val Ala  Asn Ala Trp Phe Trp  Val Ala Leu            
    2390                 2395                 2400                        

ttt tgt  cag ctg ttg gtg tgt  gct ggc ttc ctc ctc  ttc ttc cgg        7254
Phe Cys  Gln Leu Leu Val Cys  Ala Gly Phe Leu Leu  Phe Phe Arg            
    2405                 2410                 2415                        

aaa gag  cag ctt tcc aaa cct  tga                                     7278
Lys Glu  Gln Leu Ser Lys Pro                                              
    2420                 2425                                             


<210>  6
<211>  2425
<212>  PRT
<213>  aspergillus niger

<400>  6

Met Lys Trp Ala Ile Ser Gly Thr Leu Leu Ala Cys Phe Ala Thr Thr 
1               5                   10                  15      


Ala Thr Ala Trp Pro Tyr Asp Glu Ser Leu Val Asp Tyr Asn Phe Asn 
            20                  25                  30          


Gln Asn Gln Ser Ala Thr Asn Pro Ala Asp Tyr Trp Gly Thr Trp Pro 
        35                  40                  45              


Asn His Thr Gly Asp Tyr Phe Pro Ser Pro Asp Asn Trp Arg Phe Pro 
    50                  55                  60                  


Val Tyr Thr Leu Phe Leu Asp Arg Phe Val Asn Gly Asp Pro Thr Asn 
65                  70                  75                  80  


Asp Asn Ile Asn Gly Thr Leu Phe Glu His Asp Leu Arg Ser Asn Gln 
                85                  90                  95      


Met Arg His Gly Gly Asp Val Ala Gly Leu Leu Asp Thr Leu Asp Tyr 
            100                 105                 110         


Leu Gln Gly Met Gly Ile Lys Gly Leu Tyr Leu Ala Gly Thr Ile Leu 
        115                 120                 125             


Met Asn Gln Pro Trp Gly Ser Asp Gly Tyr Ser Ala Leu Asp Thr Thr 
    130                 135                 140                 


Leu Leu Asp Gln His Tyr Gly Asn Leu Gln Thr Trp Arg Asn Ala Ile 
145                 150                 155                 160 


Thr Glu Ile His Lys Arg Gly Met Tyr Val Ile Phe Asp Asn Thr Ile 
                165                 170                 175     


Ala Thr Met Gly Asp Leu Ile Gly Phe Asp Gly Tyr Leu Asn Thr Thr 
            180                 185                 190         


Thr Pro Phe Ser Val Lys Glu His Gln Thr Val Trp Lys Thr Asp Arg 
        195                 200                 205             


Arg Tyr Val Asp Phe Asp Ile Gly Asn Asp Tyr Asn Glu Thr Cys Asp 
    210                 215                 220                 


Tyr Pro Arg Phe Trp Phe Glu Asp Gly Tyr Pro Val Gln Ala Ser Val 
225                 230                 235                 240 


Thr Glu Glu Leu Val Gly Cys Tyr Asn Ser Asp Phe Asp Gln Tyr Gly 
                245                 250                 255     


Asp Ile Glu Ala Phe Gly Val Phe Pro Asp Trp Gln Arg Gln Leu Ala 
            260                 265                 270         


Lys Phe Ala Ser Val Gln Asp Arg Leu Arg Glu Trp Val Pro Ser Val 
        275                 280                 285             


Arg Glu Arg Leu Ile Arg His Ser Cys Ile Ile Ile Gln Ser Leu Asp 
    290                 295                 300                 


Ile Asp Gly Phe Arg Tyr Asp Lys Ala Thr Gln Ala Thr Val Asp Ala 
305                 310                 315                 320 


Leu Gly Asp Met Ser Asn Ala Tyr Arg Glu Cys Ala Arg Ala Val Gly 
                325                 330                 335     


Lys Glu Asn Phe Phe Ile Ala Gly Glu Ile Thr Gly Gly Asn Thr Phe 
            340                 345                 350         


Gly Ser Ile Tyr Leu Gly Arg Gly Arg Gln Pro Asn Gln Phe Pro Asp 
        355                 360                 365             


Ser Ala Glu Ala Ala Met Lys Leu Thr Asn Thr Ser Asp Ala Gln Tyr 
    370                 375                 380                 


Phe Leu Arg Glu Val Gly His Glu Ala Ile Asp Gly Ala Ala Phe His 
385                 390                 395                 400 


Tyr Ser Ile Tyr Arg Ala Leu Thr Arg Phe Leu Gly Met Asp Gly Asn 
                405                 410                 415     


Leu Ala Ala Gly Tyr Asp Val Pro Val Asp Trp Val Asp Ala Trp Asn 
            420                 425                 430         


Leu Met Leu Gln Ser Asn Asp Leu Val Asn Ala Asn Thr Gly Lys Phe 
        435                 440                 445             


Asp Pro Arg His Met Tyr Gly Ala Thr Asn Gln Asp Val Phe Arg Trp 
    450                 455                 460                 


Pro Thr Val Glu Lys Gly Val Glu Arg Gln Leu Leu Gly Leu Tyr Ile 
465                 470                 475                 480 


Thr Thr Leu Leu Leu Pro Gly Ile Pro Leu Leu Leu Trp Gly Glu Glu 
                485                 490                 495     


Gln Ala Phe Tyr Val Leu Asp Ala Thr Ala Ser Asn Tyr Ile Tyr Gly 
            500                 505                 510         


Arg Gln Ala Met Ser Pro Ala Thr Ala Trp Arg Asp His Gly Cys Phe 
        515                 520                 525             


Ser Leu Glu Ser Ser Gln Tyr Tyr Asn Trp Pro Ile Glu Ser Gly Arg 
    530                 535                 540                 


Gln Gly Cys His Asp Pro Thr Val Ala Tyr Asp His Arg Asp Pro Ser 
545                 550                 555                 560 


His Pro Val Arg Asn Ile Ile Lys His Met Tyr Gln Met Arg Glu Gln 
                565                 570                 575     


Phe Pro Val Leu Asn Asp Gly Tyr Thr Ile Gln Lys Leu Ser Asn His 
            580                 585                 590         


Thr Glu Asp Val Tyr Tyr Leu Gly Ser Asn Gly Thr Ala Thr Glu Thr 
        595                 600                 605             


Gly Leu Trp Ser Ile Leu Arg Asp Val Asn Ala Asp Val Gln Asp Leu 
    610                 615                 620                 


Gly Ser Asp Ala Lys Asn Gln Pro Val Trp Leu Val Tyr His Asn Thr 
625                 630                 635                 640 


Asn Arg Thr Ile Asp Tyr Lys Phe Asp Cys Ser Asp Asn Asp Thr Ala 
                645                 650                 655     


Leu Ile Ala Pro Phe Asp Ser Gly Thr Trp Val Lys Asn Leu Phe His 
            660                 665                 670         


Pro Tyr Asp Glu His Gln Leu Ile Asp Ser Pro Thr Lys Leu Gly Leu 
        675                 680                 685             


Asn Gly Ser Thr Ala Tyr Ser Gly Cys Leu Ala Asn Met Thr Met Ser 
    690                 695                 700                 


Ala Tyr Glu Phe Arg Ala Tyr Val Pro Lys Thr Arg Phe Thr Lys Pro 
705                 710                 715                 720 


Arg Pro Met Ile Thr Lys Phe Thr Pro Gly His Asp Val Pro Ile Arg 
                725                 730                 735     


Ser Thr Val Ala Pro Asn Ala Asp Glu Asn Val Glu Val Glu Ile Tyr 
            740                 745                 750         


Phe Ser Glu Glu Met Asp Cys Asp Ser Val Thr Lys Ser Ile Thr Leu 
        755                 760                 765             


Ser Ser Ser Thr Glu Ile Gly Lys Ala Pro Ser Val Asp Ser Gly Ser 
    770                 775                 780                 


Val Asn Cys Lys Ser Val Pro Ala Thr Asn Thr Ser Trp Thr Gly Gln 
785                 790                 795                 800 


Ile Pro Gly Val Trp Met Trp Ala Ala Asn Leu Thr Gly Val Tyr Asn 
                805                 810                 815     


Gly Ile His Arg Leu Thr Val Asn Asn Val Ser Thr Glu Ser Gly Asn 
            820                 825                 830         


Ala Thr Thr Asn Ala Val Asp His Phe Leu Phe Arg Ile Gly Gln Ile 
        835                 840                 845             


Asp Asn Pro Met Ile Phe Ser Ser Ala Asn Tyr Ser Thr Ser Leu Leu 
    850                 855                 860                 


His Lys Glu Ser Asn Gly Thr Leu Phe Ile Gln His His Ala Ala Gly 
865                 870                 875                 880 


Ala Asp Lys Tyr Arg Tyr Ser Thr Asn Trp Gly Thr Thr Phe Ser Asp 
                885                 890                 895     


Trp Ile Asp Tyr Arg Gly Gly Asn Asp Thr Ile Glu Glu Leu Glu Trp 
            900                 905                 910         


Ser Gly Thr Lys Lys Gln Ser Trp Lys Gly Asn His Val Arg Val Glu 
        915                 920                 925             


Tyr Trp Ser Arg Trp Thr Gly Ser Ser Asp Tyr Val Gln Glu Gly Asp 
    930                 935                 940                 


Ala Gly Trp Asn Glu Asn Val Pro Arg Arg Phe Pro His Val Phe Phe 
945                 950                 955                 960 


Asn Gly Pro Tyr Asn Gln Tyr Gly Tyr Asp Ala Gly Leu Asp Asn Val 
                965                 970                 975     


Val Arg Gln Asp Ser Val Asp Gly Leu Trp Lys Tyr His Phe Thr Ala 
            980                 985                 990         


Glu Trp Pro Ala Gln Ala Gln Leu  Asn Ile Trp Gly Met  Asn Pro Asp 
        995                 1000                 1005             


Gly Glu  Pro Asp Gln Ser Trp  Val Leu Gly Asp Ala  Asp Asn Asp 
    1010                 1015                 1020             


Ser Val  Leu Asp Arg Met Pro  Pro Ser Ser Leu Ser  Ala Thr Leu 
    1025                 1030                 1035             


Ile Asn  Ile Thr Glu His Pro  Pro Ser Pro Tyr Ile  Ser Trp Asn 
    1040                 1045                 1050             


Ile Phe  Ile Asp Asp Gly Thr  Met Arg Phe Gln Leu  Phe Pro Val 
    1055                 1060                 1065             


Gly His  Gln Asn Thr Gln Ile  Ala Met Tyr Val Leu  Phe Trp Ile 
    1070                 1075                 1080             


Ile Pro  Val Ile Thr Gly Ala  Ala Gly Val Trp Ala  Phe Met Lys 
    1085                 1090                 1095             


Ser Phe  Tyr Lys Val Lys Phe  Asn Gln Val Gly Val  Ser Glu Lys 
    1100                 1105                 1110             


His Gln  Met Ile Pro Leu Ala  Leu Arg Arg Lys Phe  Lys Arg Asn 
    1115                 1120                 1125             


Arg Asn  Arg Gly Gly Asp Glu  Glu Asn Ser Asn Pro  Leu Met Arg 
    1130                 1135                 1140             


Leu Ala  Asn Lys Ser Gly Phe  Leu Gln Thr Asp Thr  Ala Ile Gly 
    1145                 1150                 1155             


Gly Ala  Ala Ser Gly Lys Arg  Arg Met Val Leu Ile  Ala Thr Met 
    1160                 1165                 1170             


Glu Tyr  Asp Ile Glu Asp Trp  Ala Ile Lys Ile Lys  Ile Gly Gly 
    1175                 1180                 1185             


Leu Gly  Val Met Ala Gln Leu  Met Gly Lys Thr Leu  Gly His Gln 
    1190                 1195                 1200             


Asp Leu  Ile Trp Val Val Pro  Cys Val Gly Gly Val  Asp Tyr Pro 
    1205                 1210                 1215             


Val Asp  Lys Pro Ala Glu Pro  Met His Val Thr Ile  Leu Gly Asn 
    1220                 1225                 1230             


Ser Tyr  Glu Val Gln Val Gln  Tyr His Val Leu Asn  Asn Ile Thr 
    1235                 1240                 1245             


Tyr Val  Leu Leu Asp Ala Pro  Val Phe Arg Gln Gln  Ser Lys Ser 
    1250                 1255                 1260             


Glu Pro  Tyr Pro Ala Arg Met  Asp Asp Leu Asn Ser  Ala Ile Tyr 
    1265                 1270                 1275             


Tyr Ser  Ala Trp Asn Gln Cys  Ile Ala Glu Ala Cys  Lys Arg Phe 
    1280                 1285                 1290             


Pro Ile  Asp Leu Tyr His Ile  Asn Asp Tyr His Gly  Ser Leu Ala 
    1295                 1300                 1305             


Pro Leu  Tyr Leu Leu Pro Asp  Thr Val Pro Ala Cys  Leu Ser Leu 
    1310                 1315                 1320             


His Asn  Ala Glu Phe Gln Gly  Leu Trp Pro Met Arg  Thr Gln Lys 
    1325                 1330                 1335             


Glu Lys  Glu Glu Val Cys Ser  Val Phe Asn Leu Asp  Ile Glu Thr 
    1340                 1345                 1350             


Val Arg  His Tyr Val Gln Phe  Gly Glu Val Phe Asn  Leu Leu His 
    1355                 1360                 1365             


Ser Gly  Ala Ser Tyr Leu Arg  Val His Gln Gln Gly  Phe Gly Ala 
    1370                 1375                 1380             


Val Gly  Val Ser Lys Lys Tyr  Gly Lys Arg Ser Tyr  Ala Arg Tyr 
    1385                 1390                 1395             


Pro Ile  Phe Trp Gly Leu Arg  Lys Val Gly Asn Leu  Pro Asn Pro 
    1400                 1405                 1410             


Asp Pro  Ser Asp Val Gly Glu  Trp Ser Lys Glu Gln  Ala Ser Ala 
    1415                 1420                 1425             


Met Gly  Asp Asn Val Ser Val  Asp Pro Thr Tyr Glu  Ala Gly Arg 
    1430                 1435                 1440             


Gly Asp  Leu Lys Arg Gln Ala  Gln Glu Trp Ala Gly  Leu Glu Gln 
    1445                 1450                 1455             


Asn Pro  Asp Ala Asp Leu Leu  Val Phe Val Gly Arg  Trp Ser Met 
    1460                 1465                 1470             


Gln Lys  Gly Val Asp Leu Ile  Ala Asp Val Met Pro  Ala Val Leu 
    1475                 1480                 1485             


Glu Ala  Arg Pro Asn Val Gln  Leu Ile Cys Val Gly  Pro Val Ile 
    1490                 1495                 1500             


Asp Leu  Tyr Gly Lys Phe Ala  Ala Leu Lys Leu Asp  His Met Met 
    1505                 1510                 1515             


Lys Val  Tyr Pro Gly Arg Val  Phe Ser Arg Pro Glu  Phe Thr Ala 
    1520                 1525                 1530             


Leu Pro  Pro Tyr Ile Phe Ser  Gly Ala Glu Phe Ala  Leu Ile Pro 
    1535                 1540                 1545             


Ser Arg  Asp Glu Pro Phe Gly  Leu Val Ala Val Glu  Phe Gly Arg 
    1550                 1555                 1560             


Lys Gly  Ala Leu Gly Ile Gly  Ala Arg Val Gly Gly  Leu Gly Gln 
    1565                 1570                 1575             


Met Pro  Gly Trp Trp Tyr Asn  Val Glu Ser Thr Ala  Thr Ser His 
    1580                 1585                 1590             


Leu Leu  Val Gln Phe Lys Leu  Ala Ile Asp Ala Ala  Leu Ser Ser 
    1595                 1600                 1605             


Lys Thr  Glu Thr Arg Ala Met  Met Arg Ala Arg Ser  Ala Lys Gln 
    1610                 1615                 1620             


Arg Phe  Pro Val Ala Gln Trp  Val Glu Asp Leu Glu  Ile Leu Gln 
    1625                 1630                 1635             


Thr Thr  Ala Ile Gln Val His  Asn Lys Glu Leu Val  Lys His Asn 
    1640                 1645                 1650             


Gly Arg  Pro Phe Thr Pro Ser  Gly Thr Thr Thr Pro  Gly Gly Ile 
    1655                 1660                 1665             


Leu Ser  Gln Pro Ser Ser Pro  Leu Met Pro Pro Gly  Met Gln Thr 
    1670                 1675                 1680             


Pro Leu  Ala His Ser Arg Glu  Ser Ser Tyr Ser Asn  Leu Asn Arg 
    1685                 1690                 1695             


Leu Ser  Glu Tyr Val Thr Asp  Pro Lys Thr Asn Tyr  Ser Arg Asp 
    1700                 1705                 1710             


Ile Ser  Pro Ser Gly Thr Glu  Lys Pro Arg Ser Gly  Leu Gln Arg 
    1715                 1720                 1725             


Gln Leu  Ser Leu Gly Val Arg  Ser Gly Pro Gly His  Gln Glu Arg 
    1730                 1735                 1740             


Arg Gly  Arg Arg Gly Arg Gln  Arg Asp Ser Ile Pro  Glu His Glu 
    1745                 1750                 1755             


Asp Thr  Ala Gly Ala Met Thr  Asp Val Glu Glu Asp  His Glu Asp 
    1760                 1765                 1770             


Ile Gly  Asp Gln Gln Asp Ala  Asp Asp Glu Tyr Thr  Leu Thr Pro 
    1775                 1780                 1785             


Ala Gln  Val Glu Glu Gly Arg  Arg Leu Gln Ala Val  Gln Gln Gln 
    1790                 1795                 1800             


Gly Val  Gly Met Pro Thr Ser  Pro Gly Val Arg Arg  Tyr Ser Gln 
    1805                 1810                 1815             


Asp Ser  Leu His Pro Arg Gln  Leu Pro Ser Ser Pro  Gly Pro Val 
    1820                 1825                 1830             


Pro Pro  Pro Thr Gln Ser Leu  Leu Pro Pro Pro Arg  Leu Gly Asp 
    1835                 1840                 1845             


Ala Gly  Ser Arg Leu Ser Ser  Ala Ser Val Leu Ser  Leu Asp Ser 
    1850                 1855                 1860             


Val Val  Gly Thr Lys Thr Asp  Phe Lys Leu Gln Lys  Val Asp Pro 
    1865                 1870                 1875             


Phe Phe  Thr Asp Ser Thr Gly  Glu Tyr Tyr Lys Ala  Phe Asp Lys 
    1880                 1885                 1890             


Arg Leu  Val Gly Leu Asn Gly  Ser Asn Ser Glu Ser  Gln Leu Cys 
    1895                 1900                 1905             


Ile Glu  Glu Tyr Leu Ile Lys  Ser Glu Lys Glu Trp  Phe Asp Lys 
    1910                 1915                 1920             


Phe Arg  Asp Ala Arg Leu Gly  Arg Leu Lys Ser Pro  Ala Ser Ser 
    1925                 1930                 1935             


Val Phe  Arg Asp Lys His Gly  Ala Ser Pro Val Gly  Ser Tyr Tyr 
    1940                 1945                 1950             


Asp Asp  Thr Gly Ser Arg Val  Ser Gly Asp Tyr Asp  Arg Glu Ser 
    1955                 1960                 1965             


Arg Asp  Thr Glu Asp Asp Glu  Phe Leu Leu Gly Lys  Asp Tyr Val 
    1970                 1975                 1980             


Pro Pro  Thr Gly Leu Arg Lys  Trp Met Gln Ile Arg  Val Gly Asp 
    1985                 1990                 1995             


Trp Pro  Val Tyr Ser Leu Phe  Leu Ala Leu Gly Gln  Ile Ile Ala 
    2000                 2005                 2010             


Ala Asn  Ser Tyr Gln Val Thr  Leu Leu Thr Gly Glu  Val Gly Glu 
    2015                 2020                 2025             


Thr Ala  Glu Lys Leu Tyr Gly  Ile Ala Thr Thr Tyr  Leu Ile Thr 
    2030                 2035                 2040             


Ser Ile  Leu Trp Trp Leu Val  Phe Arg Tyr Phe Lys  Ser Val Val 
    2045                 2050                 2055             


Cys Leu  Ser Ala Pro Trp Phe  Phe Tyr Gly Leu Ala  Phe Leu Leu 
    2060                 2065                 2070             


Ile Gly  Ser Ala His Phe Glu  Pro Asn Ser Phe Asn  Arg Gly Trp 
    2075                 2080                 2085             


Ile Gln  Asn Ile Gly Ser Gly  Cys Tyr Ala Ala Ala  Ser Ser Ser 
    2090                 2095                 2100             


Gly Ser  Ile Phe Phe Ala Leu  Asn Phe Gly Asp Glu  Gly Gly Ala 
    2105                 2110                 2115             


Pro Val  Glu Thr Trp Ile Phe  Arg Ala Cys Leu Ile  Gln Gly Ile 
    2120                 2125                 2130             


Gln Ser  Ala Tyr Ile Ile Gly  Leu Trp Tyr Trp Gly  Ser Thr Leu 
    2135                 2140                 2145             


Thr Lys  Ala Ser Ser Gln Gly  Leu Leu Thr Ser Thr  Asn Asn Ile 
    2150                 2155                 2160             


Ala Asn  Ser Trp Lys Met Thr  Ala Ile Cys Tyr Pro  Ile Ala Ile 
    2165                 2170                 2175             


Phe Leu  Trp Ala Val Gly Leu  Leu Leu Leu Phe Gly  Leu Pro Asn 
    2180                 2185                 2190             


Tyr Tyr  Arg Gln Thr Pro Gly  Lys Val Ala Ser Phe  Tyr Lys Ser 
    2195                 2200                 2205             


Val Phe  Arg Arg Lys Ile Val  Leu Trp Asn Phe Val  Ala Val Ile 
    2210                 2215                 2220             


Leu Gln  Asn Phe Phe Leu Ser  Ala Pro Tyr Gly Arg  Asn Trp Gly 
    2225                 2230                 2235             


Phe Leu  Trp Ser Ser Asn His  Ala Lys Ala Trp Gln  Ile Val Ile 
    2240                 2245                 2250             


Leu Cys  Ile Val Phe Tyr Gly  Phe Val Trp Ala Gly  Phe Leu Phe 
    2255                 2260                 2265             


Val Val  Ser Arg Tyr Phe Lys  Ser His Ser Trp Phe  Leu Pro Val 
    2270                 2275                 2280             


Phe Ala  Cys Gly Leu Gly Ala  Pro Arg Phe Ile Gln  Ile Trp Trp 
    2285                 2290                 2295             


Gly Val  Ser Gly Ile Gly Tyr  Phe Leu Pro Trp Val  Ser Gly Gly 
    2300                 2305                 2310             


Tyr Leu  Gly Gly Ala Leu Ala  Ser Arg Ser Leu Trp  Leu Trp Leu 
    2315                 2320                 2325             


Gly Val  Leu Asp Ser Ile Gln  Gly Leu Gly Phe Gly  Ile Ile Leu 
    2330                 2335                 2340             


Leu Gln  Thr Leu Thr Arg Met  His Met Leu Phe Thr  Leu Ile Cys 
    2345                 2350                 2355             


Ser Gln  Val Leu Gly Ser Ile  Ala Thr Ile Cys Ala  Arg Ala Phe 
    2360                 2365                 2370             


Ala Pro  Asn Asn Val Gly Pro  Gly Pro Val Ser Pro  Asp Pro Thr 
    2375                 2380                 2385             


Phe Gly  Gly Ser Ala Val Ala  Asn Ala Trp Phe Trp  Val Ala Leu 
    2390                 2395                 2400             


Phe Cys  Gln Leu Leu Val Cys  Ala Gly Phe Leu Leu  Phe Phe Arg 
    2405                 2410                 2415             


Lys Glu  Gln Leu Ser Lys Pro  
    2420                 2425 


<210>  7
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer agsA1 (sense)

<400>  7
ggtggcggcc gcctgtgaat agctaccagc                                        30


<210>  8
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer agsA2 (antisense)

<400>  8
ctccactagt tgctaatgta ttatccatga                                        30


<210>  9
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer agsA3 (sense)

<400>  9
cttctagagt ttaaacaacc gcctcagcag                                        30


<210>  10
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer agsA4 (antisense)

<400>  10
ttaattaaag aagggcattc tatggacgta                                        30


<210>  11
<211>  28
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer agsE1 (sense)

<400>  11
accgcggtct ttcagccagg gaatggct                                          28


<210>  12
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer agsE2 (antisense)

<400>  12
ttactagtac acaatagtgc aggtgatgtc                                        30


<210>  13
<211>  29
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer agsE3 (sense)

<400>  13
tttctagacg ccttaatgat gtggtggtg                                         29


<210>  14
<211>  28
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer agsE4 (antisense)

<400>  14
ttaattaaat ggcgcccact gctacagg                                          28


<210>  15
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Forward primer (agsA5)

<400>  15
agcagtctcg gcggcgagga                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Reverse primer (agsA6)

<400>  16
attgcccaag cggcgtctca                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Forward primer (agsE5)

<400>  17
accgggcatg aacatttaac                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Reverse primer (agsE6)

<400>  18
aagtatttat tgtattttgg                                                   20


<210>  19
<211>  33
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer ap025-1 (sense)

<400>  19
tttggatcca ccatgcgttt catttctgtc tcc                                    33


<210>  20
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer ap025-2 (antisense)

<400>  20
ccacgtgtta gcaaccaagg tatatggcat                                        30


<210>  21
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Forward primer (ap025-3)

<400>  21
aggatcagtt cctgctccgg                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Reverse primer (ap025-4)

<400>  22
ggtatatggc attcgcatag                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Forward primer (ap025-3)

<400>  23
aggatcagtt cctgctccgg                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Reverse primer (ap025-4)

<400>  24
ggtatatggc attcgcatag                                                   20


