                         SEQUENCE LISTING

<110>  Bristol-Myers Squibb Company
 
<120>  Modified FGF-21 Polypeptides and Uses Thereof

<130>  43270.2213

<141>  2015-10-23

<150>  US 62/068,296
<151>  2014-10-24

<150>  US 62/068,514
<151>  2014-10-24

<150>  US 62/068,523
<151>  2014-10-24

<150>  US 62/068,526
<151>  2014-10-24

<150>  US 62/068,534
<151>  2014-10-24

<150>  US 62/141,337
<151>  2015-04-01

<150>  US 62/141,383
<151>  2015-04-01

<160>  487   

<170>  PatentIn version 3.5

<210>  1
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  1

His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
1               5                   10                  15      


Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 
            20                  25                  30          


Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 
        35                  40                  45              


Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 
    50                  55                  60                  


Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 
65                  70                  75                  80  


Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 
                85                  90                  95      


Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 
            100                 105                 110         


Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro 
        115                 120                 125             


Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 
    130                 135                 140                 


Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser 
                165                 170                 175     


Pro Ser Tyr Ala Ser 
            180     


<210>  2
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  2

Met His His His His His His Ser Gly Gly His Pro Ile Pro Asp Ser 
1               5                   10                  15      


Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr 
            20                  25                  30          


Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp 
        35                  40                  45              


Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln 
    50                  55                  60                  


Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr 
65                  70                  75                  80  


Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu 
                85                  90                  95      


His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp 
            100                 105                 110         


Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu 
        115                 120                 125             


Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala 
    130                 135                 140                 


Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro 
145                 150                 155                 160 


Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu 
                165                 170                 175     


Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
            180                 185                 190     


<210>  3
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser 
1               5                   10                  15      


Val Leu Ala Gly Leu Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro 
            20                  25                  30          


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
        35                  40                  45              


Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 
    50                  55                  60                  


Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 
65                  70                  75                  80  


Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
                85                  90                  95      


Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 
            100                 105                 110         


Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 
        115                 120                 125             


Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 
    130                 135                 140                 


His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly 
145                 150                 155                 160 


Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu 
                165                 170                 175     


Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp 
            180                 185                 190         


Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
        195                 200                 205             


Ser 
    


<210>  4
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser 
1               5                   10                  15      


Val Leu Ala Gly Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro Asp 
            20                  25                  30          


Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu 
        35                  40                  45              


Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu 
    50                  55                  60                  


Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu 
65                  70                  75                  80  


Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys 
                85                  90                  95      


Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser 
            100                 105                 110         


Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu 
        115                 120                 125             


Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His 
    130                 135                 140                 


Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro 
145                 150                 155                 160 


Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro 
                165                 170                 175     


Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro 
            180                 185                 190         


Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
        195                 200                 205             


<210>  5
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  5

His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
1               5                   10                  15      


Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 
            20                  25                  30          


Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 
        35                  40                  45              


Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 
    50                  55                  60                  


Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 
65                  70                  75                  80  


Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 
                85                  90                  95      


Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 
            100                 105                 110         


Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro 
        115                 120                 125             


Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 
    130                 135                 140                 


Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser 
                165                 170                 175     


Pro Ser Tyr Ala Ser 
            180     


<210>  6
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser 
1               5                   10                  15      


Val Leu Ala Gly Leu Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro 
            20                  25                  30          


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
        35                  40                  45              


Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 
    50                  55                  60                  


Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 
65                  70                  75                  80  


Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
                85                  90                  95      


Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 
            100                 105                 110         


Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 
        115                 120                 125             


Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 
    130                 135                 140                 


His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly 
145                 150                 155                 160 


Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu 
                165                 170                 175     


Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp 
            180                 185                 190         


Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
        195                 200                 205             


Ser 
    


<210>  7
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser 
1               5                   10                  15      


Val Leu Ala Gly Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro Asp 
            20                  25                  30          


Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu 
        35                  40                  45              


Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu 
    50                  55                  60                  


Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu 
65                  70                  75                  80  


Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys 
                85                  90                  95      


Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser 
            100                 105                 110         


Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu 
        115                 120                 125             


Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His 
    130                 135                 140                 


Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro 
145                 150                 155                 160 


Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu Pro 
                165                 170                 175     


Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro 
            180                 185                 190         


Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
        195                 200                 205             


<210>  8
<211>  546
<212>  DNA
<213>  Homo sapiens

<400>  8
caccccatcc ctgactccag tcctctcctg caattcgggg gccaagtccg gcagcggtac     60

ctctacacag atgatgccca gcagacagaa gcccacctgg agatcaggga ggatgggacg    120

gtggggggcg ctgctgacca gagccccgaa agtctcctgc agctgaaagc cttgaagccg    180

ggagttattc aaatcttggg agtcaagaca tccaggttcc tgtgccagcg gccagatggg    240

gccctgtatg gatcgctcca ctttgaccct gaggcctgca gcttccggga gctgcttctt    300

gaggacggat acaatgttta ccagtccgaa gcccacggcc tcccgctgca cctgccaggg    360

aacaagtccc cacaccggga ccctgcaccc cgaggaccag ctcgcttcct gccactacca    420

ggcctgcccc ccgcaccccc ggagccaccc ggaatcctgg ccccccagcc ccccgatgtg    480

ggctcctcgg accctctgag catggtggga ccttcccagg gccgaagccc cagctacgct    540

tcctga                                                               546


<210>  9
<211>  576
<212>  DNA
<213>  Homo sapiens

<400>  9
atgcatcatc atcatcatca tagcggcggc caccccatcc ctgactccag tcctctcctg     60

caattcgggg gccaagtccg gcagcggtac ctctacacag atgatgccca gcagacagaa    120

gcccacctgg agatcaggga ggatgggacg gtggggggcg ctgctgacca gagccccgaa    180

agtctcctgc agctgaaagc cttgaagccg ggagttattc aaatcttggg agtcaagaca    240

tccaggttcc tgtgccagcg gccagatggg gccctgtatg gatcgctcca ctttgaccct    300

gaggcctgca gcttccggga gctgcttctt gaggacggat acaatgttta ccagtccgaa    360

gcccacggcc tcccgctgca cctgccaggg aacaagtccc cacaccggga ccctgcaccc    420

cgaggaccag ctcgcttcct gccactacca ggcctgcccc ccgcaccccc ggagccaccc    480

ggaatcctgg ccccccagcc ccccgatgtg ggctcctcgg accctctgag catggtggga    540

ccttcccagg gccgaagccc cagctacgct tcctga                              576


<210>  10
<211>  630
<212>  DNA
<213>  Homo sapiens

<400>  10
atggactcgg acgagaccgg gttcgagcac tcaggactgt gggtttctgt gctggctggt     60

cttctgctgg gagcctgcca ggcacacccc atccctgact ccagtcctct cctgcaattc    120

gggggccaag tccggcagcg gtacctctac acagatgatg cccagcagac agaagcccac    180

ctggagatca gggaggatgg gacggtgggg ggcgctgctg accagagccc cgaaagtctc    240

ctgcagctga aagccttgaa gccgggagtt attcaaatct tgggagtcaa gacatccagg    300

ttcctgtgcc agcggccaga tggggccctg tatggatcgc tccactttga ccctgaggcc    360

tgcagcttcc gggagctgct tcttgaggac ggatacaatg tttaccagtc cgaagcccac    420

ggcctcccgc tgcacctgcc agggaacaag tccccacacc gggaccctgc accccgagga    480

ccagctcgct tcctgccact accaggcctg ccccccgcac ccccggagcc acccggaatc    540

ctggcccccc agccccccga tgtgggctcc tcggaccctc tgagcatggt gggaccttcc    600

cagggccgaa gccccagcta cgcttcctga                                     630


<210>  11
<211>  627
<212>  DNA
<213>  Homo sapiens

<400>  11
atggactcgg acgagaccgg gttcgagcac tcaggactgt gggtttctgt gctggctggt     60

cttctgggag cctgccaggc acaccccatc cctgactcca gtcctctcct gcaattcggg    120

ggccaagtcc ggcagcggta cctctacaca gatgatgccc agcagacaga agcccacctg    180

gagatcaggg aggatgggac ggtggggggc gctgctgacc agagccccga aagtctcctg    240

cagctgaaag ccttgaagcc gggagttatt caaatcttgg gagtcaagac atccaggttc    300

ctgtgccagc ggccagatgg ggccctgtat ggatcgctcc actttgaccc tgaggcctgc    360

agcttccggg agctgcttct tgaggacgga tacaatgttt accagtccga agcccacggc    420

ctcccgctgc acctgccagg gaacaagtcc ccacaccggg accctgcacc ccgaggacca    480

gctcgcttcc tgccactacc aggcctgccc cccgcacccc cggagccacc cggaatcctg    540

gccccccagc cccccgatgt gggctcctcg gaccctctga gcatggtggg accttcccag    600

ggccgaagcc ccagctacgc ttcctga                                        627


<210>  12
<211>  545
<212>  DNA
<213>  homo sapiens

<400>  12
caccccatcc ctgactccag tcctctcctg caattcgggg gccaagtccg gcagcggtac     60

ctctacacag atgatgccca gcagacagaa gcccacctgg agatcaggga ggatgggacg    120

gtggggggcg ctgctgacca gagccccgaa agtctcctgc agctgaaagc cttgaagccg    180

ggagttattc aaatcttggg agtcaagaca tccaggttcc tgtgccagcg gccagatggg    240

gccctgtatg gatcgctcca ctttgaccct gaggcctgca gcttccggga gctgcttctt    300

gaggacggat acaatgttta ccagtccgaa gcccacggcc tcccgctgca cctgccaggg    360

aacaagtccc cacaccggga ccctgcaccc cgaggaccag ctcgcttcct gccactacca    420

ggcctgcccc ccgcactccc ggagccaccc ggaatcctgg ccccccagcc ccccgatgtg    480

ggctcctcgg accctctgag catggtggga ccttcccagg gccgaagccc agctacgctt    540

cctga                                                                545


<210>  13
<211>  630
<212>  DNA
<213>  Homo sapiens

<400>  13
atggactcgg acgagaccgg gttcgagcac tcaggactgt gggtttctgt gctggctggt     60

cttctgctgg gagcctgcca ggcacacccc atccctgact ccagtcctct cctgcaattc    120

gggggccaag tccggcagcg gtacctctac acagatgatg cccagcagac agaagcccac    180

ctggagatca gggaggatgg gacggtgggg ggcgctgctg accagagccc cgaaagtctc    240

ctgcagctga aagccttgaa gccgggagtt attcaaatct tgggagtcaa gacatccagg    300

ttcctgtgcc agcggccaga tggggccctg tatggatcgc tccactttga ccctgaggcc    360

tgcagcttcc gggagctgct tcttgaggac ggatacaatg tttaccagtc cgaagcccac    420

ggcctcccgc tgcacctgcc agggaacaag tccccacacc gggaccctgc accccgagga    480

ccagctcgct tcctgccact accaggcctg ccccccgcac tcccggagcc acccggaatc    540

ctggcccccc agccccccga tgtgggctcc tcggaccctc tgagcatggt gggaccttcc    600

cagggccgaa gccccagcta cgcttcctga                                     630


<210>  14
<211>  627
<212>  DNA
<213>  Homo sapiens

<400>  14
atggactcgg acgagaccgg gttcgagcac tcaggactgt gggtttctgt gctggctggt     60

cttctgggag cctgccaggc acaccccatc cctgactcca gtcctctcct gcaattcggg    120

ggccaagtcc ggcagcggta cctctacaca gatgatgccc agcagacaga agcccacctg    180

gagatcaggg aggatgggac ggtggggggc gctgctgacc agagccccga aagtctcctg    240

cagctgaaag ccttgaagcc gggagttatt caaatcttgg gagtcaagac atccaggttc    300

ctgtgccagc ggccagatgg ggccctgtat ggatcgctcc actttgaccc tgaggcctgc    360

agcttccggg agctgcttct tgaggacgga tacaatgttt accagtccga agcccacggc    420

ctcccgctgc acctgccagg gaacaagtcc ccacaccggg accctgcacc ccgaggacca    480

gctcgcttcc tgccactacc aggcctgccc cccgcactcc cggagccacc cggaatcctg    540

gccccccagc cccccgatgt gggctcctcg gaccctctga gcatggtggg accttcccag    600

ggccgaagcc ccagctacgc ttcctga                                        627


<210>  15
<211>  77
<212>  DNA
<213>  Artificial

<220>
<223>  Mutant tRNA derived from Methanococcus jannaschii tRNA

<400>  15
ccggcggtag ttcagcaggg cagaacggcg gactctaaat ccgcatggcg ctggttcaaa     60

tccagcccgc cggacca                                                    77


<210>  16
<211>  306
<212>  PRT
<213>  Artificial

<220>
<223>  Mutant synthetase derived from Methanococcus jannaschii 
       synthetase

<400>  16

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Val 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Tyr Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Glu His Gly Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Gly Ile His 
145                 150                 155                 160 


Tyr Glu Gly Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile 
                165                 170                 175     


His Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His 
            180                 185                 190         


Asn Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser 
        195                 200                 205             


Lys Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala 
    210                 215                 220                 


Lys Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro 
225                 230                 235                 240 


Ile Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys 
                245                 250                 255     


Arg Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu 
            260                 265                 270         


Leu Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys 
        275                 280                 285             


Asn Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys 
    290                 295                 300                 


Arg Leu 
305     


<210>  17
<211>  77
<212>  DNA
<213>  Methanococcus jannaschii

<400>  17
ccggcggtag ttcagcaggg cagaacggcg gactctaaat ccgcatggcg ctggttcaaa     60

tccggcccgc cggacca                                                    77


<210>  18
<211>  88
<212>  DNA
<213>  Artificial

<220>
<223>  An optimized amber supressor tRNA

<400>  18
cccagggtag ccaagctcgg ccaacggcga cggactctaa atccgttctc gtaggagttc     60

gagggttcga atcccttccc tgggacca                                        88


<210>  19
<211>  89
<212>  DNA
<213>  Artificial

<220>
<223>  An optimized AGGA frameshift supressor tRNA

<400>  19
gcgagggtag ccaagctcgg ccaacggcga cggacttcct aatccgttct cgtaggagtt     60

cgagggttcg aatccctccc ctcgcacca                                       89


<210>  20
<211>  306
<212>  PRT
<213>  Artificial

<220>
<223>  Aminoacyl tRNA synthetase for the incorporation of 
       p-azido-L-phenylalanine

<400>  20

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Gly 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Thr Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Thr Tyr Tyr 
145                 150                 155                 160 


Tyr Leu Gly Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile 
                165                 170                 175     


His Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His 
            180                 185                 190         


Asn Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser 
        195                 200                 205             


Lys Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala 
    210                 215                 220                 


Lys Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro 
225                 230                 235                 240 


Ile Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys 
                245                 250                 255     


Arg Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu 
            260                 265                 270         


Leu Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys 
        275                 280                 285             


Asn Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys 
    290                 295                 300                 


Arg Leu 
305     


<210>  21
<211>  306
<212>  PRT
<213>  Artificial

<220>
<223>  Aminoacyl tRNA synthetase for the incorporation of 
       p-benzoyl-L-phenylalanine

<400>  21

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Gly 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Ser Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Thr Ser His 
145                 150                 155                 160 


Tyr Leu Gly Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile 
                165                 170                 175     


His Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His 
            180                 185                 190         


Asn Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser 
        195                 200                 205             


Lys Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala 
    210                 215                 220                 


Lys Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro 
225                 230                 235                 240 


Ile Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys 
                245                 250                 255     


Arg Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu 
            260                 265                 270         


Leu Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys 
        275                 280                 285             


Asn Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys 
    290                 295                 300                 


Arg Leu 
305     


<210>  22
<211>  305
<212>  PRT
<213>  Artificial

<220>
<223>  Aminoacyl tRNA synthetase for the incorporation of 
       propargyl-phenylalanine

<400>  22

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Ala 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Pro Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Ala Ile Tyr 
145                 150                 155                 160 


Leu Ala Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile His 
                165                 170                 175     


Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His Asn 
            180                 185                 190         


Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser Lys 
        195                 200                 205             


Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala Lys 
    210                 215                 220                 


Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro Ile 
225                 230                 235                 240 


Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys Arg 
                245                 250                 255     


Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu Leu 
            260                 265                 270         


Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys Asn 
        275                 280                 285             


Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys Arg 
    290                 295                 300                 


Leu 
305 


<210>  23
<211>  305
<212>  PRT
<213>  Artificial

<220>
<223>  Aminoacyl tRNA synthetase for the incorporation of 
       propargyl-phenylalanine

<400>  23

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Ala 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Pro Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Ile Pro Tyr 
145                 150                 155                 160 


Leu Pro Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile His 
                165                 170                 175     


Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His Asn 
            180                 185                 190         


Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser Lys 
        195                 200                 205             


Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala Lys 
    210                 215                 220                 


Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro Ile 
225                 230                 235                 240 


Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys Arg 
                245                 250                 255     


Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu Leu 
            260                 265                 270         


Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys Asn 
        275                 280                 285             


Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys Arg 
    290                 295                 300                 


Leu 
305 


<210>  24
<211>  305
<212>  PRT
<213>  Artificial

<220>
<223>  Aminoacyl tRNA synthetase for the incorporation of 
       propargyl-phenylalanine

<400>  24

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Ala 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Lys Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Ala Ile Tyr 
145                 150                 155                 160 


Leu Ala Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile His 
                165                 170                 175     


Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His Asn 
            180                 185                 190         


Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser Lys 
        195                 200                 205             


Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala Lys 
    210                 215                 220                 


Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro Ile 
225                 230                 235                 240 


Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys Arg 
                245                 250                 255     


Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu Leu 
            260                 265                 270         


Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys Asn 
        275                 280                 285             


Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys Arg 
    290                 295                 300                 


Leu 
305 


<210>  25
<211>  306
<212>  PRT
<213>  Artificial

<220>
<223>  Aminoacyl tRNA synthetase  for the incorporation of 
       p-azido-phenylalanine

<400>  25

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Thr 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Asn Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Pro Leu His 
145                 150                 155                 160 


Tyr Gln Gly Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile 
                165                 170                 175     


His Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His 
            180                 185                 190         


Asn Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser 
        195                 200                 205             


Lys Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala 
    210                 215                 220                 


Lys Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro 
225                 230                 235                 240 


Ile Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys 
                245                 250                 255     


Arg Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu 
            260                 265                 270         


Leu Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys 
        275                 280                 285             


Asn Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys 
    290                 295                 300                 


Arg Leu 
305     


<210>  26
<211>  306
<212>  PRT
<213>  Artificial

<220>
<223>  Aminoacyl tRNA synthetase  for the incorporation of 
       p-azido-phenylalanine

<400>  26

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Thr 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Ser Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Pro Leu His 
145                 150                 155                 160 


Tyr Gln Gly Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile 
                165                 170                 175     


His Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His 
            180                 185                 190         


Asn Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser 
        195                 200                 205             


Lys Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala 
    210                 215                 220                 


Lys Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro 
225                 230                 235                 240 


Ile Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys 
                245                 250                 255     


Arg Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu 
            260                 265                 270         


Leu Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys 
        275                 280                 285             


Asn Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys 
    290                 295                 300                 


Arg Leu 
305     


<210>  27
<211>  306
<212>  PRT
<213>  Artificial

<220>
<223>  Aminoacyl tRNA synthetase for the incorporation of 
       p-azido-phenylalanine

<400>  27

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Leu 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Thr Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Pro Val His 
145                 150                 155                 160 


Tyr Gln Gly Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile 
                165                 170                 175     


His Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His 
            180                 185                 190         


Asn Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser 
        195                 200                 205             


Lys Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala 
    210                 215                 220                 


Lys Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro 
225                 230                 235                 240 


Ile Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys 
                245                 250                 255     


Arg Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu 
            260                 265                 270         


Leu Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys 
        275                 280                 285             


Asn Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys 
    290                 295                 300                 


Arg Leu 
305     


<210>  28
<211>  306
<212>  PRT
<213>  Artificial

<220>
<223>  Aminoacyl tRNA synthetase  for the incorporation of 
       p-azido-phenylalanine

<400>  28

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Thr 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Ser Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Pro Ser His 
145                 150                 155                 160 


Tyr Gln Gly Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile 
                165                 170                 175     


His Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His 
            180                 185                 190         


Asn Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser 
        195                 200                 205             


Lys Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala 
    210                 215                 220                 


Lys Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro 
225                 230                 235                 240 


Ile Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys 
                245                 250                 255     


Arg Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu 
            260                 265                 270         


Leu Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys 
        275                 280                 285             


Asn Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys 
    290                 295                 300                 


Arg Leu 
305     


<210>  29
<211>  306
<212>  PRT
<213>  Artificial

<220>
<223>  Aminoacyl tRNA synthetase  for the incorporation of 
       p-acetyl-phenylalanine

<400>  29

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Leu 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Glu Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Gly Cys His 
145                 150                 155                 160 


Tyr Arg Gly Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile 
                165                 170                 175     


His Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His 
            180                 185                 190         


Asn Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser 
        195                 200                 205             


Lys Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala 
    210                 215                 220                 


Lys Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro 
225                 230                 235                 240 


Ile Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys 
                245                 250                 255     


Arg Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu 
            260                 265                 270         


Leu Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys 
        275                 280                 285             


Asn Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys 
    290                 295                 300                 


Arg Leu 
305     


<210>  30
<211>  306
<212>  PRT
<213>  Artificial

<220>
<223>  Aminoacyl tRNA synthetase  for the incorporation of p-acetyl 
       -phenylalanine

<400>  30

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Leu 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Glu Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Gly Thr His 
145                 150                 155                 160 


Tyr Arg Gly Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile 
                165                 170                 175     


His Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His 
            180                 185                 190         


Asn Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser 
        195                 200                 205             


Lys Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala 
    210                 215                 220                 


Lys Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro 
225                 230                 235                 240 


Ile Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys 
                245                 250                 255     


Arg Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu 
            260                 265                 270         


Leu Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys 
        275                 280                 285             


Asn Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys 
    290                 295                 300                 


Arg Leu 
305     


<210>  31
<211>  306
<212>  PRT
<213>  Artificial

<220>
<223>  Aminoacyl tRNA synthetase  for the incorporation of 
       p-acetyl-phenylalanine

<400>  31

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Ala 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Glu Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Gly Gly His 
145                 150                 155                 160 


Tyr Leu Gly Val Asp Val Ile Val Gly Gly Met Glu Gln Arg Lys Ile 
                165                 170                 175     


His Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His 
            180                 185                 190         


Asn Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser 
        195                 200                 205             


Lys Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala 
    210                 215                 220                 


Lys Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro 
225                 230                 235                 240 


Ile Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys 
                245                 250                 255     


Arg Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu 
            260                 265                 270         


Leu Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys 
        275                 280                 285             


Asn Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys 
    290                 295                 300                 


Arg Leu 
305     


<210>  32
<211>  306
<212>  PRT
<213>  Artificial

<220>
<223>  Aminoacyl tRNA synthetase  for the incorporation of 
       p-azido-phenylalanine

<400>  32

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Ala 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Arg Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Val Ile His 
145                 150                 155                 160 


Tyr Asp Gly Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile 
                165                 170                 175     


His Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His 
            180                 185                 190         


Asn Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser 
        195                 200                 205             


Lys Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala 
    210                 215                 220                 


Lys Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro 
225                 230                 235                 240 


Ile Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys 
                245                 250                 255     


Arg Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu 
            260                 265                 270         


Leu Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys 
        275                 280                 285             


Asn Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys 
    290                 295                 300                 


Arg Leu 
305     


<210>  33
<211>  306
<212>  PRT
<213>  Artificial

<220>
<223>  Aminoacyl tRNA synthetase  for the incorporation of 
       p-azido-phenylalanine

<400>  33

Met Asp Glu Phe Glu Met Ile Lys Arg Asn Thr Ser Glu Ile Ile Ser 
1               5                   10                  15      


Glu Glu Glu Leu Arg Glu Val Leu Lys Lys Asp Glu Lys Ser Ala Gly 
            20                  25                  30          


Ile Gly Phe Glu Pro Ser Gly Lys Ile His Leu Gly His Tyr Leu Gln 
        35                  40                  45              


Ile Lys Lys Met Ile Asp Leu Gln Asn Ala Gly Phe Asp Ile Ile Ile 
    50                  55                  60                  


Leu Leu Ala Asp Leu His Ala Tyr Leu Asn Gln Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Glu Ile Arg Lys Ile Gly Asp Tyr Asn Lys Lys Val Phe Glu Ala Met 
                85                  90                  95      


Gly Leu Lys Ala Lys Tyr Val Tyr Gly Ser Thr Phe Gln Leu Asp Lys 
            100                 105                 110         


Asp Tyr Thr Leu Asn Val Tyr Arg Leu Ala Leu Lys Thr Thr Leu Lys 
        115                 120                 125             


Arg Ala Arg Arg Ser Met Glu Leu Ile Ala Arg Glu Asp Glu Asn Pro 
    130                 135                 140                 


Lys Val Ala Glu Val Ile Tyr Pro Ile Met Gln Val Asn Thr Tyr Tyr 
145                 150                 155                 160 


Tyr Leu Gly Val Asp Val Ala Val Gly Gly Met Glu Gln Arg Lys Ile 
                165                 170                 175     


His Met Leu Ala Arg Glu Leu Leu Pro Lys Lys Val Val Cys Ile His 
            180                 185                 190         


Asn Pro Val Leu Thr Gly Leu Asp Gly Glu Gly Lys Met Ser Ser Ser 
        195                 200                 205             


Lys Gly Asn Phe Ile Ala Val Asp Asp Ser Pro Glu Glu Ile Arg Ala 
    210                 215                 220                 


Lys Ile Lys Lys Ala Tyr Cys Pro Ala Gly Val Val Glu Gly Asn Pro 
225                 230                 235                 240 


Ile Met Glu Ile Ala Lys Tyr Phe Leu Glu Tyr Pro Leu Thr Ile Lys 
                245                 250                 255     


Arg Pro Glu Lys Phe Gly Gly Asp Leu Thr Val Asn Ser Tyr Glu Glu 
            260                 265                 270         


Leu Glu Ser Leu Phe Lys Asn Lys Glu Leu His Pro Met Asp Leu Lys 
        275                 280                 285             


Asn Ala Val Ala Glu Glu Leu Ile Lys Ile Leu Glu Pro Ile Arg Lys 
    290                 295                 300                 


Arg Leu 
305     


<210>  34
<211>  208
<212>  PRT
<213>  Rattus norvegicus

<400>  34

Met Asp Trp Met Lys Ser Arg Val Gly Ala Pro Gly Leu Trp Val Cys 
1               5                   10                  15      


Leu Leu Leu Pro Val Phe Leu Leu Gly Val Cys Glu Ala Tyr Pro Ile 
            20                  25                  30          


Ser Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg 
        35                  40                  45              


Tyr Leu Tyr Thr Asp Asp Asp Gln Asp Thr Glu Ala His Leu Glu Ile 
    50                  55                  60                  


Arg Glu Asp Gly Thr Val Val Gly Thr Ala His Arg Ser Pro Glu Ser 
65                  70                  75                  80  


Leu Leu Glu Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly 
                85                  90                  95      


Val Lys Ala Ser Arg Phe Leu Cys Gln Gln Pro Asp Gly Thr Leu Tyr 
            100                 105                 110         


Gly Ser Pro His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu 
        115                 120                 125             


Leu Lys Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro 
    130                 135                 140                 


Leu Arg Leu Pro Gln Lys Asp Ser Gln Asp Pro Ala Thr Arg Gly Pro 
145                 150                 155                 160 


Val Arg Phe Leu Pro Met Pro Gly Leu Pro His Glu Pro Gln Glu Gln 
                165                 170                 175     


Pro Gly Val Leu Pro Pro Glu Pro Pro Asp Val Gly Ser Ser Asp Pro 
            180                 185                 190         


Leu Ser Met Val Glu Pro Leu Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
        195                 200                 205             


<210>  35
<211>  210
<212>  PRT
<213>  Mus musculus

<400>  35

Met Glu Trp Met Arg Ser Arg Val Gly Thr Leu Gly Leu Trp Val Arg 
1               5                   10                  15      


Leu Leu Leu Ala Val Phe Leu Leu Gly Val Tyr Gln Ala Tyr Pro Ile 
            20                  25                  30          


Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg 
        35                  40                  45              


Tyr Leu Tyr Thr Asp Asp Asp Gln Asp Thr Glu Ala His Leu Glu Ile 
    50                  55                  60                  


Arg Glu Asp Gly Thr Val Val Gly Ala Ala His Arg Ser Pro Glu Ser 
65                  70                  75                  80  


Leu Leu Glu Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly 
                85                  90                  95      


Val Lys Ala Ser Arg Phe Leu Cys Gln Gln Pro Asp Gly Ala Leu Tyr 
            100                 105                 110         


Gly Ser Pro His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu 
        115                 120                 125             


Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro 
    130                 135                 140                 


Leu Arg Leu Pro Gln Lys Asp Ser Pro Asn Gln Asp Ala Thr Ser Trp 
145                 150                 155                 160 


Gly Pro Val Arg Phe Leu Pro Met Pro Gly Leu Leu His Glu Pro Gln 
                165                 170                 175     


Asp Gln Ala Gly Phe Leu Pro Pro Glu Pro Pro Asp Val Gly Ser Ser 
            180                 185                 190         


Asp Pro Leu Ser Met Val Glu Pro Leu Gln Gly Arg Ser Pro Ser Tyr 
        195                 200                 205             


Ala Ser 
    210 


<210>  36
<211>  194
<212>  PRT
<213>  Danio rerio

<400>  36

Met Leu Phe Ala Cys Phe Phe Ile Phe Phe Ala Leu Phe Pro His Leu 
1               5                   10                  15      


Arg Trp Cys Met Tyr Val Pro Ala Gln Asn Val Leu Leu Gln Phe Gly 
            20                  25                  30          


Thr Gln Val Arg Glu Arg Leu Leu Tyr Thr Asp Gly Leu Phe Leu Glu 
        35                  40                  45              


Met Asn Pro Asp Gly Ser Val Lys Gly Ser Pro Glu Lys Asn Leu Asn 
    50                  55                  60                  


Cys Val Leu Glu Leu Arg Ser Val Lys Ala Gly Glu Thr Val Ile Gln 
65                  70                  75                  80  


Ser Ala Ala Thr Ser Leu Tyr Leu Cys Val Asp Asp Gln Asp Lys Leu 
                85                  90                  95      


Lys Gly Gln His His Tyr Ser Ala Leu Asp Cys Thr Phe Gln Glu Leu 
            100                 105                 110         


Leu Leu Asp Gly Tyr Ser Phe Phe Leu Ser Pro His Thr Asn Leu Pro 
        115                 120                 125             


Val Ser Leu Leu Ser Lys Arg Gln Lys His Gly Asn Pro Leu Ser Arg 
    130                 135                 140                 


Phe Leu Pro Val Ser Arg Ala Glu Asp Ser Arg Thr Gln Glu Val Lys 
145                 150                 155                 160 


Gln Tyr Ile Gln Asp Ile Asn Leu Asp Ser Asp Asp Pro Leu Gly Met 
                165                 170                 175     


Gly His Arg Ser His Leu Gln Thr Val Phe Ser Pro Ser Leu His Thr 
            180                 185                 190         


Lys Lys 
        


<210>  37
<211>  1043
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Lys Pro Gly Cys Ala Ala Gly Ser Pro Gly Asn Glu Trp Ile Phe 
1               5                   10                  15      


Phe Ser Thr Asp Glu Ile Thr Thr Arg Tyr Arg Asn Thr Met Ser Asn 
            20                  25                  30          


Gly Gly Leu Gln Arg Ser Val Ile Leu Ser Ala Leu Ile Leu Leu Arg 
        35                  40                  45              


Ala Val Thr Gly Phe Ser Gly Asp Gly Arg Ala Ile Trp Ser Lys Asn 
    50                  55                  60                  


Pro Asn Phe Thr Pro Val Asn Glu Ser Gln Leu Phe Leu Tyr Asp Thr 
65                  70                  75                  80  


Phe Pro Lys Asn Phe Phe Trp Gly Ile Gly Thr Gly Ala Leu Gln Val 
                85                  90                  95      


Glu Gly Ser Trp Lys Lys Asp Gly Lys Gly Pro Ser Ile Trp Asp His 
            100                 105                 110         


Phe Ile His Thr His Leu Lys Asn Val Ser Ser Thr Asn Gly Ser Ser 
        115                 120                 125             


Asp Ser Tyr Ile Phe Leu Glu Lys Asp Leu Ser Ala Leu Asp Phe Ile 
    130                 135                 140                 


Gly Val Ser Phe Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro 
145                 150                 155                 160 


Asp Gly Ile Val Thr Val Ala Asn Ala Lys Gly Leu Gln Tyr Tyr Ser 
                165                 170                 175     


Thr Leu Leu Asp Ala Leu Val Leu Arg Asn Ile Glu Ile Val Thr Leu 
            180                 185                 190         


Tyr His Trp Asp Leu Pro Leu Ala Leu Gln Glu Lys Tyr Gly Gly Trp 
        195                 200                 205             


Lys Asn Asp Thr Ile Ile Asp Ile Phe Asn Asp Tyr Ala Thr Tyr Cys 
    210                 215                 220                 


Phe Gln Met Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His Asn 
225                 230                 235                 240 


Pro Tyr Leu Val Ala Trp His Gly Tyr Gly Thr Gly Met His Ala Pro 
                245                 250                 255     


Gly Glu Lys Gly Asn Leu Ala Ala Val Tyr Thr Val Gly His Asn Leu 
            260                 265                 270         


Ile Lys Ala His Ser Lys Val Trp His Asn Tyr Asn Thr His Phe Arg 
        275                 280                 285             


Pro His Gln Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp Ile 
    290                 295                 300                 


Glu Pro Asn Arg Ser Glu Asn Thr Met Asp Ile Phe Lys Cys Gln Gln 
305                 310                 315                 320 


Ser Met Val Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly Asp 
                325                 330                 335     


Gly Asp Tyr Pro Glu Gly Met Arg Lys Lys Leu Phe Ser Val Leu Pro 
            340                 345                 350         


Ile Phe Ser Glu Ala Glu Lys His Glu Met Arg Gly Thr Ala Asp Phe 
        355                 360                 365             


Phe Ala Phe Ser Phe Gly Pro Asn Asn Phe Lys Pro Leu Asn Thr Met 
    370                 375                 380                 


Ala Lys Met Gly Gln Asn Val Ser Leu Asn Leu Arg Glu Ala Leu Asn 
385                 390                 395                 400 


Trp Ile Lys Leu Glu Tyr Asn Asn Pro Arg Ile Leu Ile Ala Glu Asn 
                405                 410                 415     


Gly Trp Phe Thr Asp Ser Arg Val Lys Thr Glu Asp Thr Thr Ala Ile 
            420                 425                 430         


Tyr Met Met Lys Asn Phe Leu Ser Gln Val Leu Gln Ala Ile Arg Leu 
        435                 440                 445             


Asp Glu Ile Arg Val Phe Gly Tyr Thr Ala Trp Ser Leu Leu Asp Gly 
    450                 455                 460                 


Phe Glu Trp Gln Asp Ala Tyr Thr Ile Arg Arg Gly Leu Phe Tyr Val 
465                 470                 475                 480 


Asp Phe Asn Ser Lys Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala His 
                485                 490                 495     


Tyr Tyr Lys Gln Ile Ile Arg Glu Asn Gly Phe Ser Leu Lys Glu Ser 
            500                 505                 510         


Thr Pro Asp Val Gln Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly Val 
        515                 520                 525             


Thr Glu Ser Val Leu Lys Pro Glu Ser Val Ala Ser Ser Pro Gln Phe 
    530                 535                 540                 


Ser Asp Pro His Leu Tyr Val Trp Asn Ala Thr Gly Asn Arg Leu Leu 
545                 550                 555                 560 


His Arg Val Glu Gly Val Arg Leu Lys Thr Arg Pro Ala Gln Cys Thr 
                565                 570                 575     


Asp Phe Val Asn Ile Lys Lys Gln Leu Glu Met Leu Ala Arg Met Lys 
            580                 585                 590         


Val Thr His Tyr Arg Phe Ala Leu Asp Trp Ala Ser Val Leu Pro Thr 
        595                 600                 605             


Gly Asn Leu Ser Ala Val Asn Arg Gln Ala Leu Arg Tyr Tyr Arg Cys 
    610                 615                 620                 


Val Val Ser Glu Gly Leu Lys Leu Gly Ile Ser Ala Met Val Thr Leu 
625                 630                 635                 640 


Tyr Tyr Pro Thr His Ala His Leu Gly Leu Pro Glu Pro Leu Leu His 
                645                 650                 655     


Ala Asp Gly Trp Leu Asn Pro Ser Thr Ala Glu Ala Phe Gln Ala Tyr 
            660                 665                 670         


Ala Gly Leu Cys Phe Gln Glu Leu Gly Asp Leu Val Lys Leu Trp Ile 
        675                 680                 685             


Thr Ile Asn Glu Pro Asn Arg Leu Ser Asp Ile Tyr Asn Arg Ser Gly 
    690                 695                 700                 


Asn Asp Thr Tyr Gly Ala Ala His Asn Leu Leu Val Ala His Ala Leu 
705                 710                 715                 720 


Ala Trp Arg Leu Tyr Asp Arg Gln Phe Arg Pro Ser Gln Arg Gly Ala 
                725                 730                 735     


Val Ser Leu Ser Leu His Ala Asp Trp Ala Glu Pro Ala Asn Pro Tyr 
            740                 745                 750         


Ala Asp Ser His Trp Arg Ala Ala Glu Arg Phe Leu Gln Phe Glu Ile 
        755                 760                 765             


Ala Trp Phe Ala Glu Pro Leu Phe Lys Thr Gly Asp Tyr Pro Ala Ala 
    770                 775                 780                 


Met Arg Glu Tyr Ile Ala Ser Lys His Arg Arg Gly Leu Ser Ser Ser 
785                 790                 795                 800 


Ala Leu Pro Arg Leu Thr Glu Ala Glu Arg Arg Leu Leu Lys Gly Thr 
                805                 810                 815     


Val Asp Phe Cys Ala Leu Asn His Phe Thr Thr Arg Phe Val Met His 
            820                 825                 830         


Glu Gln Leu Ala Gly Ser Arg Tyr Asp Ser Asp Arg Asp Ile Gln Phe 
        835                 840                 845             


Leu Gln Asp Ile Thr Arg Leu Ser Ser Pro Thr Arg Leu Ala Val Ile 
    850                 855                 860                 


Pro Trp Gly Val Arg Lys Leu Leu Arg Trp Val Arg Arg Asn Tyr Gly 
865                 870                 875                 880 


Asp Met Asp Ile Tyr Ile Thr Ala Ser Gly Ile Asp Asp Gln Ala Leu 
                885                 890                 895     


Glu Asp Asp Arg Leu Arg Lys Tyr Tyr Leu Gly Lys Tyr Leu Gln Glu 
            900                 905                 910         


Val Leu Lys Ala Tyr Leu Ile Asp Lys Val Arg Ile Lys Gly Tyr Tyr 
        915                 920                 925             


Ala Phe Lys Leu Ala Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe Phe 
    930                 935                 940                 


Thr Ser Asp Phe Lys Ala Lys Ser Ser Ile Gln Phe Tyr Asn Lys Val 
945                 950                 955                 960 


Ile Ser Ser Arg Gly Phe Pro Phe Glu Asn Ser Ser Ser Arg Cys Ser 
                965                 970                 975     


Gln Thr Gln Glu Asn Thr Glu Cys Thr Val Cys Leu Phe Leu Val Gln 
            980                 985                 990         


Lys Lys Pro Leu Ile Phe Leu Gly  Cys Cys Phe Phe Ser  Thr Leu Val 
        995                 1000                 1005             


Leu Leu  Leu Ser Ile Ala Ile  Phe Gln Arg Gln Lys  Arg Arg Lys 
    1010                 1015                 1020             


Phe Trp  Lys Ala Lys Asn Leu  Gln His Ile Pro Leu  Lys Lys Gly 
    1025                 1030                 1035             


Lys Arg  Val Val Ser 
    1040             


<210>  38
<211>  1043
<212>  PRT
<213>  Mus musculus

<400>  38

Met Lys Thr Gly Cys Ala Ala Gly Ser Pro Gly Asn Glu Trp Ile Phe 
1               5                   10                  15      


Phe Ser Ser Asp Glu Arg Asn Thr Arg Ser Arg Lys Thr Met Ser Asn 
            20                  25                  30          


Arg Ala Leu Gln Arg Ser Ala Val Leu Ser Ala Phe Val Leu Leu Arg 
        35                  40                  45              


Ala Val Thr Gly Phe Ser Gly Asp Gly Lys Ala Ile Trp Asp Lys Lys 
    50                  55                  60                  


Gln Tyr Val Ser Pro Val Asn Pro Ser Gln Leu Phe Leu Tyr Asp Thr 
65                  70                  75                  80  


Phe Pro Lys Asn Phe Ser Trp Gly Val Gly Thr Gly Ala Phe Gln Val 
                85                  90                  95      


Glu Gly Ser Trp Lys Thr Asp Gly Arg Gly Pro Ser Ile Trp Asp Arg 
            100                 105                 110         


Tyr Val Tyr Ser His Leu Arg Gly Val Asn Gly Thr Asp Arg Ser Thr 
        115                 120                 125             


Asp Ser Tyr Ile Phe Leu Glu Lys Asp Leu Leu Ala Leu Asp Phe Leu 
    130                 135                 140                 


Gly Val Ser Phe Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro 
145                 150                 155                 160 


Asn Gly Thr Val Ala Ala Val Asn Ala Gln Gly Leu Arg Tyr Tyr Arg 
                165                 170                 175     


Ala Leu Leu Asp Ser Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr 
            180                 185                 190         


Leu Tyr His Trp Asp Leu Pro Leu Thr Leu Gln Glu Glu Tyr Gly Gly 
        195                 200                 205             


Trp Lys Asn Ala Thr Met Ile Asp Leu Phe Asn Asp Tyr Ala Thr Tyr 
    210                 215                 220                 


Cys Phe Gln Thr Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His 
225                 230                 235                 240 


Asn Pro Tyr Leu Val Ala Trp His Gly Phe Gly Thr Gly Met His Ala 
                245                 250                 255     


Pro Gly Glu Lys Gly Asn Leu Thr Ala Val Tyr Thr Val Gly His Asn 
            260                 265                 270         


Leu Ile Lys Ala His Ser Lys Val Trp His Asn Tyr Asp Lys Asn Phe 
        275                 280                 285             


Arg Pro His Gln Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp 
    290                 295                 300                 


Ile Glu Pro Asn Arg Thr Asp Asn Met Glu Asp Val Ile Asn Cys Gln 
305                 310                 315                 320 


His Ser Met Ser Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly 
                325                 330                 335     


Asp Gly Asp Tyr Pro Glu Phe Met Lys Thr Gly Ala Met Ile Pro Glu 
            340                 345                 350         


Phe Ser Glu Ala Glu Lys Glu Glu Val Arg Gly Thr Ala Asp Phe Phe 
        355                 360                 365             


Ala Phe Ser Phe Gly Pro Asn Asn Phe Arg Pro Ser Asn Thr Val Val 
    370                 375                 380                 


Lys Met Gly Gln Asn Val Ser Leu Asn Leu Arg Gln Val Leu Asn Trp 
385                 390                 395                 400 


Ile Lys Leu Glu Tyr Asp Asp Pro Gln Ile Leu Ile Ser Glu Asn Gly 
                405                 410                 415     


Trp Phe Thr Asp Ser Tyr Ile Lys Thr Glu Asp Thr Thr Ala Ile Tyr 
            420                 425                 430         


Met Met Lys Asn Phe Leu Asn Gln Val Leu Gln Ala Ile Lys Phe Asp 
        435                 440                 445             


Glu Ile Arg Val Phe Gly Tyr Thr Ala Trp Thr Leu Leu Asp Gly Phe 
    450                 455                 460                 


Glu Trp Gln Asp Ala Tyr Thr Thr Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Asn Ser Glu Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala His Tyr 
                485                 490                 495     


Tyr Lys Gln Ile Ile Gln Asp Asn Gly Phe Pro Leu Lys Glu Ser Thr 
            500                 505                 510         


Pro Asp Met Lys Gly Arg Phe Pro Cys Asp Phe Ser Trp Gly Val Thr 
        515                 520                 525             


Glu Ser Val Leu Lys Pro Glu Phe Thr Val Ser Ser Pro Gln Phe Thr 
    530                 535                 540                 


Asp Pro His Leu Tyr Val Trp Asn Val Thr Gly Asn Arg Leu Leu Tyr 
545                 550                 555                 560 


Arg Val Glu Gly Val Arg Leu Lys Thr Arg Pro Ser Gln Cys Thr Asp 
                565                 570                 575     


Tyr Val Ser Ile Lys Lys Arg Val Glu Met Leu Ala Lys Met Lys Val 
            580                 585                 590         


Thr His Tyr Gln Phe Ala Leu Asp Trp Thr Ser Ile Leu Pro Thr Gly 
        595                 600                 605             


Asn Leu Ser Lys Val Asn Arg Gln Val Leu Arg Tyr Tyr Arg Cys Val 
    610                 615                 620                 


Val Ser Glu Gly Leu Lys Leu Gly Val Phe Pro Met Val Thr Leu Tyr 
625                 630                 635                 640 


His Pro Thr His Ser His Leu Gly Leu Pro Leu Pro Leu Leu Ser Ser 
                645                 650                 655     


Gly Gly Trp Leu Asn Met Asn Thr Ala Lys Ala Phe Gln Asp Tyr Ala 
            660                 665                 670         


Glu Leu Cys Phe Arg Glu Leu Gly Asp Leu Val Lys Leu Trp Ile Thr 
        675                 680                 685             


Ile Asn Glu Pro Asn Arg Leu Ser Asp Met Tyr Asn Arg Thr Ser Asn 
    690                 695                 700                 


Asp Thr Tyr Arg Ala Ala His Asn Leu Met Ile Ala His Ala Gln Val 
705                 710                 715                 720 


Trp His Leu Tyr Asp Arg Gln Tyr Arg Pro Val Gln His Gly Ala Val 
                725                 730                 735     


Ser Leu Ser Leu His Cys Asp Trp Ala Glu Pro Ala Asn Pro Phe Val 
            740                 745                 750         


Asp Ser His Trp Lys Ala Ala Glu Arg Phe Leu Gln Phe Glu Ile Ala 
        755                 760                 765             


Trp Phe Ala Asp Pro Leu Phe Lys Thr Gly Asp Tyr Pro Ser Val Met 
    770                 775                 780                 


Lys Glu Tyr Ile Ala Ser Lys Asn Gln Arg Gly Leu Ser Ser Ser Val 
785                 790                 795                 800 


Leu Pro Arg Phe Thr Ala Lys Glu Ser Arg Leu Val Lys Gly Thr Val 
                805                 810                 815     


Asp Phe Tyr Ala Leu Asn His Phe Thr Thr Arg Phe Val Ile His Lys 
            820                 825                 830         


Gln Leu Asn Thr Asn Arg Ser Val Ala Asp Arg Asp Val Gln Phe Leu 
        835                 840                 845             


Gln Asp Ile Thr Arg Leu Ser Ser Pro Ser Arg Leu Ala Val Thr Pro 
    850                 855                 860                 


Trp Gly Val Arg Lys Leu Leu Ala Trp Ile Arg Arg Asn Tyr Arg Asp 
865                 870                 875                 880 


Arg Asp Ile Tyr Ile Thr Ala Asn Gly Ile Asp Asp Leu Ala Leu Glu 
                885                 890                 895     


Asp Asp Gln Ile Arg Lys Tyr Tyr Leu Glu Lys Tyr Val Gln Glu Ala 
            900                 905                 910         


Leu Lys Ala Tyr Leu Ile Asp Lys Val Lys Ile Lys Gly Tyr Tyr Ala 
        915                 920                 925             


Phe Lys Leu Thr Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe Phe Thr 
    930                 935                 940                 


Ser Asp Phe Arg Ala Lys Ser Ser Val Gln Phe Tyr Ser Lys Leu Ile 
945                 950                 955                 960 


Ser Ser Ser Gly Leu Pro Ala Glu Asn Arg Ser Pro Ala Cys Gly Gln 
                965                 970                 975     


Pro Ala Glu Asp Thr Asp Cys Thr Ile Cys Ser Phe Leu Val Glu Lys 
            980                 985                 990         


Lys Pro Leu Ile Phe Phe Gly Cys  Cys Phe Ile Ser Thr  Leu Ala Val 
        995                 1000                 1005             


Leu Leu  Ser Ile Thr Val Phe  His His Gln Lys Arg  Arg Lys Phe 
    1010                 1015                 1020             


Gln Lys  Ala Arg Asn Leu Gln  Asn Ile Pro Leu Lys  Lys Gly His 
    1025                 1030                 1035             


Ser Arg  Val Phe Ser 
    1040             


<210>  39
<211>  63
<212>  DNA
<213>  Artificial

<220>
<223>  FGF21 secretion constructs, cloned into pVK7ara (Nde/Eco)

<400>  39
atgaaaaaaa ctgctatcgc gatcgctgta gctctggctg gtttcgcgac cgtagctaac     60

gct                                                                   63


<210>  40
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  FGF21 secretion constructs, cloned into pVK7ara (Nde/Eco)

<400>  40

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Asn Ala 
            20      


<210>  41
<211>  78
<212>  DNA
<213>  Artificial

<220>
<223>  FGF21 secretion constructs, cloned into pVK7ara (Nde/Eco)

<400>  41
atgaaaataa aaacaggtgc acgcatcctc gcattatccg cattaacgac gatgatgttt     60

tccgcctcgg ctctcgcc                                                   78


<210>  42
<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  FGF21 secretion constructs, cloned into pVK7ara (Nde/Eco)

<400>  42

Met Lys Ile Lys Thr Gly Ala Arg Ile Leu Ala Leu Ser Ala Leu Thr 
1               5                   10                  15      


Thr Met Met Phe Ser Ala Ser Ala Leu Ala 
            20                  25      


<210>  43
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  FGF21 secretion constructs, cloned into pVK7ara (Nde/Eco)

<400>  43
atgaaaaaga atatcgcatt tcttcttgca tctatgttcg ttttttctat tgctacaaat     60

gcctatgca                                                             69


<210>  44
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  FGF21 secretion constructs, cloned into pVK7ara (Nde/Eco)

<400>  44

Met Lys Lys Asn Ile Ala Phe Leu Leu Ala Ser Met Phe Val Phe Ser 
1               5                   10                  15      


Ile Ala Thr Asn Ala Tyr Ala 
            20              


<210> 45
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic peptide

<400> 45
His Ser Tyr Tyr Glu Gln Asn Ser 
1               5               


<210> 46
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic peptide

<400> 46
Tyr Ser Gln Thr 
1               


<210> 47
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic peptide

<400> 47
Tyr Gly Ser Lys Tyr Tyr Tyr 
1               5           


<210> 48
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 48
Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Pro Lys 
1               5                   10                  15      


Tyr Asp Lys Thr Gly His Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly 
            20                  25                  30          


Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Thr Arg Gln Thr Thr 
        35                  40                  45              


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
    50                  55                  60                  


Tyr Ala Val Ser Lys Asp Asp Tyr Tyr Pro His Glu His Arg Pro Ile 
65                  70                  75                  80  


Ser Ile Asn Tyr Arg Thr 
                85      


<210> 49
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 49
Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Ser Asn 
1               5                   10                  15      


Asp Gly Pro Gly Leu Ser Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly 
            20                  25                  30          


Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Ser Ser Gln Thr Thr 
        35                  40                  45              


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
    50                  55                  60                  


Tyr Ala Val Ser Tyr Tyr Thr Lys Lys Ala Tyr Ser Ala Gly Pro Ile 
65                  70                  75                  80  


Ser Ile Asn Tyr Arg Thr 
                85      


<210> 50
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 50
Glu Met Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Glu Asp 
1               5                   10                  15      


Asp Ser Tyr Tyr Ser Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly 
            20                  25                  30          


Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Ser Asp Leu Tyr Thr 
        35                  40                  45              


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
    50                  55                  60                  


Tyr Ala Val Thr Tyr Asp Val Thr Asp Leu Ile Met His Glu Pro Ile 
65                  70                  75                  80  


Ser Ile Asn Tyr Arg Thr 
                85      


<210> 51
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 51
Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Glu Asp 
1               5                   10                  15      


Asp Ser Tyr Tyr Ser Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly 
            20                  25                  30          


Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Ser Asp Leu Tyr Thr 
        35                  40                  45              


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
    50                  55                  60                  


Tyr Ala Val Thr Tyr Asp Val Thr Asp Leu Ile Met His Glu Pro Ile 
65                  70                  75                  80  


Ser Ile Asn Tyr Arg Thr 
                85      


<210> 52
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 52
Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Tyr Met 
1               5                   10                  15      


Asp Glu Tyr Asp Val Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly 
            20                  25                  30          


Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Asn Tyr Tyr Asn Thr 
        35                  40                  45              


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
    50                  55                  60                  


Tyr Ala Val Thr Arg Ile Lys Ala Asn Asn Tyr Met Tyr Gly Pro Ile 
65                  70                  75                  80  


Ser Ile Asn Tyr Arg Thr 
                85      


<210> 53
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 53
Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asn His 
1               5                   10                  15      


Leu Glu His Val Ala Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly 
            20                  25                  30          


Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Glu Tyr Pro Thr Thr 
        35                  40                  45              


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
    50                  55                  60                  


Tyr Ala Val Thr Ile Thr Met Leu Lys Tyr Pro Thr Gln Ser Pro Ile 
65                  70                  75                  80  


Ser Ile Asn Tyr Arg Thr 
                85      


<210> 54
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 54
Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Gly His 
1               5                   10                  15      


Tyr Arg Arg Ser Gly His Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly 
            20                  25                  30          


Gly Asn Ser Pro Val Gln Glu Phe Thr Val Asp Pro Ser Ser Tyr Thr 
        35                  40                  45              


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
    50                  55                  60                  


Tyr Ala Val Ser Lys Asp Asp Tyr Tyr Pro His Glu His Arg Pro Ile 
65                  70                  75                  80  


Ser Ile Asn Tyr Arg Thr 
                85      


<210> 55
<211> 84
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 55
Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala 
1               5                   10                  15      


Ser His Tyr Glu Arg Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly 
            20                  25                  30          


Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Arg Tyr His His Thr 
        35                  40                  45              


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
    50                  55                  60                  


Tyr Ala Val Thr Gln Ala Gln Glu His Tyr Gln Pro Pro Ile Ser Ile 
65                  70                  75                  80  


Asn Tyr Arg Thr 
                


<210> 56
<211> 82
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 56
Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asn Ser 
1               5                   10                  15      


Tyr Tyr His Ser Ala Asp Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly 
            20                  25                  30          


Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Tyr Pro Pro Thr Thr 
        35                  40                  45              


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
    50                  55                  60                  


Tyr Ala Val Tyr Ser Ala Lys Ser Tyr Tyr Pro Ile Ser Ile Asn Tyr 
65                  70                  75                  80  


Arg Thr 
        


<210> 57
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 57
Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Ser Lys 
1               5                   10                  15      


Tyr Ser Lys His Gly His Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly 
            20                  25                  30          


Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Ser Gly Asn Ala Thr 
        35                  40                  45              


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
    50                  55                  60                  


Tyr Ala Val Glu Asp Thr Asn Asp Tyr Pro His Thr His Arg Pro Ile 
65                  70                  75                  80  


Ser Ile Asn Tyr Arg Thr 
                85      


<210> 58
<211> 84
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 58
Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp His Gly 
1               5                   10                  15      


Glu Pro Asp Gln Thr Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly 
            20                  25                  30          


Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Pro Tyr Arg Arg Thr 
        35                  40                  45              


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
    50                  55                  60                  


Tyr Ala Val Thr Ser Gly Tyr Thr Gly His Tyr Gln Pro Ile Ser Ile 
65                  70                  75                  80  


Asn Tyr Arg Thr 
                


<210> 59
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 59
Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Ser Lys 
1               5                   10                  15      


Tyr Ser Lys His Gly His Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly 
            20                  25                  30          


Gly Asn Ser Pro Val Gln Glu Phe Thr Val Asp Pro Ser Ser Tyr Thr 
        35                  40                  45              


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
    50                  55                  60                  


Tyr Ala Val Ser Lys Asp Asp Tyr Tyr Pro His Glu His Arg Pro Ile 
65                  70                  75                  80  


Ser Ile Asn Tyr Arg Thr 
                85      


<210> 60
<211> 82
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 60
Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Tyr Glu 
1               5                   10                  15      


Pro Tyr Thr Pro Ile His Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly 
            20                  25                  30          


Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Gly Tyr Tyr Gly Thr 
        35                  40                  45              


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
    50                  55                  60                  


Tyr Ala Val Tyr Gly Tyr Tyr Gln Tyr Thr Pro Ile Ser Ile Asn Tyr 
65                  70                  75                  80  


Arg Thr 
        


<210> 61
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 61
Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Ser Lys 
1               5                   10                  15      


Tyr Ser Lys His Gly His Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly 
            20                  25                  30          


Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Ser Gly Asn Ala Thr 
        35                  40                  45              


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
    50                  55                  60                  


Tyr Ala Val Ser Asp Asp Asn Lys Tyr Tyr His Gln His Arg Pro Ile 
65                  70                  75                  80  


Ser Ile Asn Tyr Arg Thr 
                85      


<210> 62
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 62
Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Gly His 
1               5                   10                  15      


Tyr Arg Arg Ser Gly His Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly 
            20                  25                  30          


Gly Asn Ser Pro Val Gln Glu Phe Thr Val Asp Pro Ser Ser Tyr Thr 
        35                  40                  45              


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
    50                  55                  60                  


Tyr Ala Val Ser Lys Asp Asp Tyr Tyr Pro His Glu His Arg Pro Ile 
65                  70                  75                  80  


Ser Ile Asn Tyr Arg Thr 
                85      


<210> 63
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 63
Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Ser Lys 
1               5                   10                  15      


Tyr Ser Lys His Gly His Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly 
            20                  25                  30          


Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Ser Gly Asn Ala Thr 
        35                  40                  45              


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
    50                  55                  60                  


Tyr Ala Val Glu Asp Thr Asn Asp Tyr Pro His Thr His Arg Pro Ile 
65                  70                  75                  80  


Ser Ile Asn Tyr Arg Thr 
                85      


<210> 64
<211> 82
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 64
Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Tyr Glu 
1               5                   10                  15      


Pro Gly Ala Ser Val Tyr Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly 
            20                  25                  30          


Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Ser Tyr Tyr His Thr 
        35                  40                  45              


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
    50                  55                  60                  


Tyr Ala Val Tyr Gly Tyr Tyr Glu Tyr Glu Pro Ile Ser Ile Asn Tyr 
65                  70                  75                  80  


Arg Thr 
        


<210> 65
<211> 82
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 65
Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Gln Ser 
1               5                   10                  15      


Tyr Tyr Ala His Ser Asp Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly 
            20                  25                  30          


Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Tyr Pro Pro Gln Thr 
        35                  40                  45              


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
    50                  55                  60                  


Tyr Ala Val Tyr Ala Gly Ser Ser Tyr Tyr Pro Ile Ser Ile Asn Tyr 
65                  70                  75                  80  


Arg Thr 
        


<210> 66
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 66
Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Gly His 
1               5                   10                  15      


Tyr Arg Arg Ser Gly His Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly 
            20                  25                  30          


Gly Asn Ser Pro Val Gln Glu Phe Thr Val Asp Pro Ser Ser Tyr Thr 
        35                  40                  45              


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
    50                  55                  60                  


Tyr Ala Val Ser Lys Asp Asp Tyr Tyr Pro His Glu His Arg Pro Ile 
65                  70                  75                  80  


Ser Ile Asn Tyr Arg Thr 
                85      


<210> 67
<211> 82
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 67
Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Pro Glu 
1               5                   10                  15      


Pro Gly Thr Pro Val Tyr Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly 
            20                  25                  30          


Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Ala Tyr Tyr Gly Thr 
        35                  40                  45              


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
    50                  55                  60                  


Tyr Ala Val Tyr Gly Tyr Tyr Asp Tyr Ser Pro Ile Ser Ile Asn Tyr 
65                  70                  75                  80  


Arg Thr 
        


<210> 68
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 68
Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Tyr Arg 
1               5                   10                  15      


Tyr Glu Lys Thr Gln His Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly 
            20                  25                  30          


Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Pro Glu Ser Gly Thr 
        35                  40                  45              


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
    50                  55                  60                  


Tyr Ala Val Tyr Ala Gly Tyr Glu Tyr Pro His Thr His Arg Pro Ile 
65                  70                  75                  80  


Ser Ile Asn Tyr Arg Thr 
                85      


<210> 69
<211> 87
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 69
Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Val Lys 
1               5                   10                  15      


Ser Glu Glu Tyr Tyr Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly 
            20                  25                  30          


Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Tyr Tyr Val His Thr 
        35                  40                  45              


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
    50                  55                  60                  


Tyr Ala Val Thr Glu Tyr Tyr Tyr Ala Gly Ala Val Val Ser Val Pro 
65                  70                  75                  80  


Ile Ser Ile Asn Tyr Arg Thr 
                85          


<210> 70
<211> 82
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 70
Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Tyr Asp 
1               5                   10                  15      


Pro Tyr Thr Tyr Gly Ser Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly 
            20                  25                  30          


Gly Asn Ser Pro Val Gln Glu Phe Thr Val Gly Pro Tyr Thr Thr Thr 
        35                  40                  45              


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
    50                  55                  60                  


Tyr Ala Val Ser Tyr Tyr Tyr Ser Thr Gln Pro Ile Ser Ile Asn Tyr 
65                  70                  75                  80  


Arg Thr 
        


<210> 71
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 71
Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Ser Asn 
1               5                   10                  15      


Asp Gly Pro Gly Leu Ser Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly 
            20                  25                  30          


Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Ser Ser Gln Thr Thr 
        35                  40                  45              


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
    50                  55                  60                  


Tyr Ala Val Ser Tyr Tyr Thr Lys Lys Ala Tyr Ser Ala Gly Pro Ile 
65                  70                  75                  80  


Ser Ile Asn Tyr Arg Thr 
                85      


<210> 72
<211> 82
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic polypeptide

<400> 72
Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Pro Asp 
1               5                   10                  15      


Pro Tyr Tyr Lys Pro Asp Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly 
            20                  25                  30          


Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Arg Asp Tyr Thr Thr 
        35                  40                  45              


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
    50                  55                  60                  


Tyr Ala Val Tyr Ser Tyr Tyr Gly Tyr Tyr Pro Ile Ser Ile Asn Tyr 
65                  70                  75                  80  


Arg Thr 
        

<210>  73
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  73

Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro 
1               5                   10          


<210>  74
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  74

Gly Ala Gly Gly Gly Gly Ser Gly 
1               5               


<210>  75
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  75

Glu Pro Lys Ser Ser Asp 
1               5       


<210>  76
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  76

Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala Gln Pro Gln 
1               5                   10                  15      


Ala Glu Gly Leu Ala 
            20      


<210>  77
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  77

Glu Leu Gln Leu Glu Glu Ser Ala Ala Glu Ala Gln Asp Gly Glu Leu 
1               5                   10                  15      


Asp 
    


<210>  78
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  78

Gly Gln Pro Asp Glu Pro Gly Gly Ser 
1               5                   


<210>  79
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  79

Gly Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10              


<210>  80
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  80

Glu Leu Gln Leu Glu Glu Ser Ala Ala Glu Ala Gln Glu Gly Glu Leu 
1               5                   10                  15      


Glu 
    


<210>  81
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  81

Gly Ser Gly Ser Gly 
1               5   


<210>  82
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  82

Gly Ser Gly Cys 
1               


<210>  83
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  83

Ala Gly Gly Gly Gly Ser Gly 
1               5           


<210>  84
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  84

Gly Ser Gly Ser 
1               


<210>  85
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  85

Gln Pro Asp Glu Pro Gly Gly Ser 
1               5               


<210>  86
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  86

Gly Ser Gly Ser Gly Ser 
1               5       


<210>  87
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  87

Thr Val Ala Ala Pro Ser 
1               5       


<210>  88
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  88

Lys Ala Gly Gly Gly Gly Ser Gly 
1               5               


<210>  89
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  89

Lys Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10              


<210>  90
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  90

Lys Gln Pro Asp Glu Pro Gly Gly Ser 
1               5                   


<210>  91
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  91

Lys Glu Leu Gln Leu Glu Glu Ser Ala Ala Glu Ala Gln Asp Gly Glu 
1               5                   10                  15      


Leu Asp 
        


<210>  92
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  92

Lys Thr Val Ala Ala Pro Ser 
1               5           


<210>  93
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  93

Lys Ala Gly Gly Gly Gly Ser Gly Gly 
1               5                   


<210>  94
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  94

Lys Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly 
1               5                   10                  


<210>  95
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  95

Lys Gln Pro Asp Glu Pro Gly Gly Ser Gly 
1               5                   10  


<210>  96
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  96

Lys Glu Leu Gln Leu Glu Glu Ser Ala Ala Glu Ala Gln Asp Gly Glu 
1               5                   10                  15      


Leu Asp Gly 
            


<210>  97
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  97

Lys Thr Val Ala Ala Pro Ser Gly Ala Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


<210>  98
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  98

Ala Gly Gly Gly Gly Ser Gly 
1               5           


<210>  99
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  99

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly 
1               5                   10              


<210>  100
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  100

Gln Pro Asp Glu Pro Gly Gly Ser Gly 
1               5                   


<210>  101
<211>  182
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  101

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp 
        115                 120                 125             


Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro 
    130                 135                 140                 


Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp 
145                 150                 155                 160 


Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg 
                165                 170                 175     


Ser Pro Ser Tyr Ala Ser 
            180         


<210>  102
<211>  173
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  102

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe 
        115                 120                 125             


Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile 
    130                 135                 140                 


Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met 
145                 150                 155                 160 


Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
                165                 170             


<210>  103
<211>  182
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  103

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp 
        115                 120                 125             


Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro 
    130                 135                 140                 


Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp 
145                 150                 155                 160 


Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg 
                165                 170                 175     


Ser Pro Ser Tyr Ala Ser 
            180         


<210>  104
<211>  182
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  104

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Pro Gly Lys Lys Ser Pro His Arg Asp 
        115                 120                 125             


Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro 
    130                 135                 140                 


Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp 
145                 150                 155                 160 


Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg 
                165                 170                 175     


Ser Pro Ser Tyr Ala Ser 
            180         


<210>  105
<211>  180
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  105

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Pro Gly Asp Lys Ser Arg Asp Pro Ala 
        115                 120                 125             


Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala 
    130                 135                 140                 


Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly 
145                 150                 155                 160 


Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro 
                165                 170                 175     


Ser Tyr Ala Ser 
            180 


<210>  106
<211>  180
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  106

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Pro Gly His Lys Ser Arg Asp Pro Ala 
        115                 120                 125             


Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala 
    130                 135                 140                 


Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly 
145                 150                 155                 160 


Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro 
                165                 170                 175     


Ser Tyr Ala Ser 
            180 


<210>  107
<211>  182
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  107

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Pro Gly Asp Lys Ser Pro His Arg Asp 
        115                 120                 125             


Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro 
    130                 135                 140                 


Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp 
145                 150                 155                 160 


Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg 
                165                 170                 175     


Ser Pro Ser Tyr Ala Ser 
            180         


<210>  108
<211>  170
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  108

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Gly Ser Gly Ala Arg Phe Leu Pro Leu 
        115                 120                 125             


Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 
    130                 135                 140                 


Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro 
145                 150                 155                 160 


Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
                165                 170 


<210>  109
<211>  182
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  109

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Pro Gly Gln Lys Ser Pro His Arg Asp 
        115                 120                 125             


Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro 
    130                 135                 140                 


Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp 
145                 150                 155                 160 


Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg 
                165                 170                 175     


Ser Pro Ser Tyr Ala Ser 
            180         


<210>  110
<211>  172
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  110

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Gly Ser Gly Gly Pro Ala Arg Phe Leu 
        115                 120                 125             


Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu 
    130                 135                 140                 


Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val 
145                 150                 155                 160 


Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
                165                 170         


<210>  111
<211>  179
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  111

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Gly Ser Gly His Arg Asp Pro Ala Pro 
        115                 120                 125             


Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro 
    130                 135                 140                 


Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser 
145                 150                 155                 160 


Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser 
                165                 170                 175     


Tyr Ala Ser 
            


<210>  112
<211>  180
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  112

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Pro His His Ser Gly Arg Asp Pro Ala 
        115                 120                 125             


Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala 
    130                 135                 140                 


Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly 
145                 150                 155                 160 


Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro 
                165                 170                 175     


Ser Tyr Ala Ser 
            180 


<210>  113
<211>  180
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  113

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Pro Gly Lys Asp Ser Gln Asp Pro Ala 
        115                 120                 125             


Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala 
    130                 135                 140                 


Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly 
145                 150                 155                 160 


Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro 
                165                 170                 175     


Ser Tyr Ala Ser 
            180 


<210>  114
<211>  181
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  114

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Pro Gly His His Lys Ser Arg Asp Pro 
        115                 120                 125             


Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 
    130                 135                 140                 


Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser 
                165                 170                 175     


Pro Ser Tyr Ala Ser 
            180     


<210>  115
<211>  181
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  115

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Pro Gly His His Lys Ser Arg Asp Pro 
        115                 120                 125             


Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 
    130                 135                 140                 


Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Glu 
                165                 170                 175     


Pro Ser Tyr Ala Ser 
            180     


<210>  116
<211>  180
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  116

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Pro Gly His His Lys Ser Arg Asp Pro 
        115                 120                 125             


Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 
    130                 135                 140                 


Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Leu Ser Met Val Pro Ser Gln Gly Arg Ser Pro 
                165                 170                 175     


Ser Tyr Ala Ser 
            180 


<210>  117
<211>  180
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  117

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Pro Gly His His Lys Ser Arg Asp Pro 
        115                 120                 125             


Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 
    130                 135                 140                 


Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Leu Ser Met Val Gly Ser Gln Gly Arg Ser Pro 
                165                 170                 175     


Ser Tyr Ala Ser 
            180 


<210>  118
<211>  172
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  118

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp 
        115                 120                 125             


Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro 
    130                 135                 140                 


Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp 
145                 150                 155                 160 


Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro 
                165                 170         


<210>  119
<211>  180
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  119

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Gly Ser Gly Pro His Arg Asp Pro Ala 
        115                 120                 125             


Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala 
    130                 135                 140                 


Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly 
145                 150                 155                 160 


Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro 
                165                 170                 175     


Ser Tyr Ala Ser 
            180 


<210>  120
<211>  178
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  120

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Gly Gly His Arg Asp Pro Ala Pro Arg 
        115                 120                 125             


Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro 
    130                 135                 140                 


Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser 
145                 150                 155                 160 


Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr 
                165                 170                 175     


Ala Ser 
        


<210>  121
<211>  178
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  121

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Gly Ser Gly Arg Asp Pro Ala Pro Arg 
        115                 120                 125             


Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro 
    130                 135                 140                 


Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser 
145                 150                 155                 160 


Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr 
                165                 170                 175     


Ala Ser 
        


<210>  122
<211>  176
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  122

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Ser Gly Gly Pro Ala Pro Arg Gly Pro 
        115                 120                 125             


Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro 
    130                 135                 140                 


Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro 
145                 150                 155                 160 


Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
                165                 170                 175     


<210>  123
<211>  171
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  123

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Gly Gly Gly Pro Ala Arg Phe Leu Pro 
        115                 120                 125             


Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala 
    130                 135                 140                 


Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu 
145                 150                 155                 160 


Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
                165                 170     


<210>  124
<211>  169
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  124

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Pro Gly Gly Arg Phe Leu Pro Leu Pro 
        115                 120                 125             


Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln 
    130                 135                 140                 


Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser 
145                 150                 155                 160 


Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
                165                 


<210>  125
<211>  170
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  125

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Pro Ser Gly Gly Arg Phe Leu Pro Leu 
        115                 120                 125             


Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 
    130                 135                 140                 


Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro 
145                 150                 155                 160 


Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
                165                 170 


<210>  126
<211>  175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  126

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Ser Gly Gly Pro Ala Pro Arg Gly Pro Ala 
        115                 120                 125             


Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro 
    130                 135                 140                 


Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu 
145                 150                 155                 160 


Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
                165                 170                 175 


<210>  127
<211>  171
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  127

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Gly Ser Gly Gly Pro Ala Arg Phe Leu Pro 
        115                 120                 125             


Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala 
    130                 135                 140                 


Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu 
145                 150                 155                 160 


Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
                165                 170     


<210>  128
<211>  166
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  128

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro His Gly Gly Arg Phe Leu Pro Leu Pro Gly Leu Pro 
        115                 120                 125             


Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp 
    130                 135                 140                 


Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg 
145                 150                 155                 160 


Ser Pro Ser Tyr Ala Ser 
                165     


<210>  129
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  129

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro His Ser Gly Gly Arg Phe Leu Pro Leu Pro Gly Leu 
        115                 120                 125             


Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro 
    130                 135                 140                 


Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly 
145                 150                 155                 160 


Arg Ser Pro Ser Tyr Ala Ser 
                165         


<210>  130
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  130

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro His Gly Ser Gly Arg Phe Leu Pro Leu Pro Gly Leu 
        115                 120                 125             


Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro 
    130                 135                 140                 


Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly 
145                 150                 155                 160 


Arg Ser Pro Ser Tyr Ala Ser 
                165         


<210>  131
<211>  172
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  131

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Gly Ser Gly Gly Pro Ala Arg Phe Leu 
        115                 120                 125             


Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu 
    130                 135                 140                 


Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val 
145                 150                 155                 160 


Thr Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
                165                 170         


<210>  132
<211>  187
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  132

Met His His His His His His Pro Ile Pro Asp Ser Ser Pro Leu Leu 
1               5                   10                  15      


Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala 
            20                  25                  30          


Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly 
        35                  40                  45              


Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu 
    50                  55                  60                  


Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu 
65                  70                  75                  80  


Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro 
                85                  90                  95      


Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val 
            100                 105                 110         


Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn Lys 
        115                 120                 125             


Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro 
    130                 135                 140                 


Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu Ala 
145                 150                 155                 160 


Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly 
                165                 170                 175     


Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
            180                 185         


<210> 133

<400> 133
000

<210> 134

<400> 134
000

<210> 135

<400> 135
000

<210> 136

<400> 136
000

<210> 137

<400> 137
000

<210> 138

<400> 138
000

<210> 139

<400> 139
000

<210> 140

<400> 140
000

<210> 141

<400> 141
000

<210> 142

<400> 142
000

<210> 143

<400> 143
000

<210> 144

<400> 144
000

<210> 145

<400> 145
000

<210> 146

<400> 146
000

<210> 147

<400> 147
000

<210> 148

<400> 148
000

<210> 149

<400> 149
000

<210> 150

<400> 150
000

<210> 151

<400> 151
000

<210> 152

<400> 152
000

<210> 153

<400> 153
000

<210> 154

<400> 154
000

<210> 155

<400> 155
000

<210> 156

<400> 156
000

<210> 157

<400> 157
000

<210> 158

<400> 158
000

<210> 159

<400> 159
000

<210> 160

<400> 160
000

<210> 161

<400> 161
000

<210> 162

<400> 162
000

<210> 163

<400> 163
000

<210> 164

<400> 164
000

<210> 165

<400> 165
000

<210> 166

<400> 166
000

<210> 167

<400> 167
000

<210> 168

<400> 168
000

<210> 169

<400> 169
000

<210> 170

<400> 170
000

<210> 171

<400> 171
000

<210> 172

<400> 172
000

<210> 173

<400> 173
000

<210> 174

<400> 174
000

<210> 175

<400> 175
000

<210> 176

<400> 176
000

<210> 177

<400> 177
000

<210> 178

<400> 178
000

<210> 179

<400> 179
000

<210> 180

<400> 180
000

<210> 181

<400> 181
000

<210> 182

<400> 182
000

<210> 183

<400> 183
000

<210> 184

<400> 184
000

<210> 185

<400> 185
000

<210> 186

<400> 186
000

<210> 187

<400> 187
000

<210> 188

<400> 188
000

<210> 189

<400> 189
000

<210> 190

<400> 190
000

<210> 191

<400> 191
000

<210> 192

<400> 192
000

<210> 193

<400> 193
000

<210> 194

<400> 194
000

<210> 195

<400> 195
000

<210> 196

<400> 196
000

<210> 197

<400> 197
000

<210> 198

<400> 198
000

<210> 199

<400> 199
000

<210> 200

<400> 200
000

<210>  201
<211>  182
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Para-acetyl-L-phenylalanine optionally linked to a 30 kDa 
       poly(ethylene glycol)

<400>  201

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Xaa Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp 
        115                 120                 125             


Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro 
    130                 135                 140                 


Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp 
145                 150                 155                 160 


Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg 
                165                 170                 175     


Ser Pro Ser Tyr Ala Ser 
            180         


<210>  202
<211>  173
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Para-acetyl-L-phenylalanine optionally linked to a 30 kDa 
       poly(ethylene glycol)

<400>  202

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Xaa Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe 
        115                 120                 125             


Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile 
    130                 135                 140                 


Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met 
145                 150                 155                 160 


Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
                165                 170             


<210> 203

<400> 203
000

<210> 204

<400> 204
000

<210>  205
<211>  180
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Para-acetyl-L-phenylalanine optionally linked to a 30 kDa 
       poly(ethylene glycol)

<400>  205

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Xaa Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Pro Gly Asp Lys Ser Arg Asp Pro Ala 
        115                 120                 125             


Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala 
    130                 135                 140                 


Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly 
145                 150                 155                 160 


Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro 
                165                 170                 175     


Ser Tyr Ala Ser 
            180 


<210>  206
<211>  180
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Para-acetyl-L-phenylalanine optionally linked to a 30 kDa 
       poly(ethylene glycol)


<400>  206

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Xaa Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Pro Gly His Lys Ser Arg Asp Pro Ala 
        115                 120                 125             


Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala 
    130                 135                 140                 


Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly 
145                 150                 155                 160 


Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro 
                165                 170                 175     


Ser Tyr Ala Ser 
            180 


<210> 207

<400> 207
000

<210> 208

<400> 208
000

<210> 209

<400> 209
000

<210>  210
<211>  172
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Para-acetyl-L-phenylalanine optionally linked to a 30 kDa 
       poly(ethylene glycol)


<400>  210

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Xaa Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Gly Ser Gly Gly Pro Ala Arg Phe Leu 
        115                 120                 125             


Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu 
    130                 135                 140                 


Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val 
145                 150                 155                 160 


Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
                165                 170         


<210>  211
<211>  179
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Para-acetyl-L-phenylalanine optionally linked to a 30 kDa 
       poly(ethylene glycol)


<400>  211

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Xaa Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Gly Ser Gly His Arg Asp Pro Ala Pro 
        115                 120                 125             


Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro 
    130                 135                 140                 


Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser 
145                 150                 155                 160 


Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser 
                165                 170                 175     


Tyr Ala Ser 
            


<210>  212
<211>  180
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Para-acetyl-L-phenylalanine optionally linked to a 30 kDa 
       poly(ethylene glycol)


<400>  212

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Xaa Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Pro His His Ser Gly Arg Asp Pro Ala 
        115                 120                 125             


Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala 
    130                 135                 140                 


Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly 
145                 150                 155                 160 


Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro 
                165                 170                 175     


Ser Tyr Ala Ser 
            180 


<210> 213

<400> 213
000

<210> 214

<400> 214
000

<210> 215

<400> 215
000

<210> 216

<400> 216
000

<210> 217

<400> 217
000

<210> 218

<400> 218
000

<210>  219
<211>  180
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Para-acetyl-L-phenylalanine optionally linked to a 30 kDa 
       poly(ethylene glycol)


<400>  219

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Xaa Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Gly Ser Gly Pro His Arg Asp Pro Ala 
        115                 120                 125             


Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala 
    130                 135                 140                 


Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly 
145                 150                 155                 160 


Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro 
                165                 170                 175     


Ser Tyr Ala Ser 
            180 


<210>  220
<211>  178
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Para-acetyl-L-phenylalanine optionally linked to a 30 kDa 
       poly(ethylene glycol)


<400>  220

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Xaa Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Gly Gly His Arg Asp Pro Ala Pro Arg 
        115                 120                 125             


Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro 
    130                 135                 140                 


Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser 
145                 150                 155                 160 


Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr 
                165                 170                 175     


Ala Ser 
        


<210>  221
<211>  178
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Para-acetyl-L-phenylalanine optionally linked to a 30 kDa 
       poly(ethylene glycol)


<400>  221

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Xaa Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Gly Ser Gly Arg Asp Pro Ala Pro Arg 
        115                 120                 125             


Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro 
    130                 135                 140                 


Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser 
145                 150                 155                 160 


Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr 
                165                 170                 175     


Ala Ser 
        


<210>  222
<211>  176
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Para-acetyl-L-phenylalanine optionally linked to a 30 kDa 
       poly(ethylene glycol)


<400>  222

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Xaa Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Ser Gly Gly Pro Ala Pro Arg Gly Pro 
        115                 120                 125             


Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro 
    130                 135                 140                 


Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro 
145                 150                 155                 160 


Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
                165                 170                 175     


<210>  223
<211>  171
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Para-acetyl-L-phenylalanine optionally linked to a 30 kDa 
       poly(ethylene glycol)


<400>  223

Met His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
1               5                   10                  15      


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            20                  25                  30          


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        35                  40                  45              


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    50                  55                  60                  


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
65                  70                  75                  80  


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                85                  90                  95      


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Xaa Ser Glu Ala 
            100                 105                 110         


His Gly Leu Pro Leu His Leu Gly Gly Gly Pro Ala Arg Phe Leu Pro 
        115                 120                 125             


Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala 
    130                 135                 140                 


Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu 
145                 150                 155                 160 


Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
                165                 170     


<210> 224

<400> 224
000


<210> 225

<400> 225
000


<210> 226

<400> 226
000


<210> 227

<400> 227
000


<210> 228

<400> 228
000


<210> 229

<400> 229
000


<210> 230

<400> 230
000


<210> 231

<400> 231
000


<210> 232

<400> 232
000


<210> 233

<400> 233
000


<210> 234

<400> 234
000


<210> 235

<400> 235
000


<210> 236

<400> 236
000


<210> 237

<400> 237
000


<210> 238

<400> 238
000


<210> 239

<400> 239
000


<210> 240

<400> 240
000


<210> 241

<400> 241
000


<210> 242

<400> 242
000


<210> 243

<400> 243
000


<210> 244

<400> 244
000


<210> 245

<400> 245
000


<210> 246

<400> 246
000


<210> 247

<400> 247
000


<210> 248

<400> 248
000


<210> 249

<400> 249
000


<210> 250

<400> 250
000


<210> 251

<400> 251
000


<210> 252

<400> 252
000


<210> 253

<400> 253
000


<210> 254

<400> 254
000


<210> 255

<400> 255
000


<210> 256

<400> 256
000


<210> 257

<400> 257
000


<210> 258

<400> 258
000


<210> 259

<400> 259
000


<210> 260

<400> 260
000


<210> 261

<400> 261
000


<210> 262

<400> 262
000


<210> 263

<400> 263
000


<210> 264

<400> 264
000


<210> 265

<400> 265
000


<210> 266

<400> 266
000


<210> 267

<400> 267
000


<210> 268

<400> 268
000


<210> 269

<400> 269
000


<210> 270

<400> 270
000


<210> 271

<400> 271
000


<210> 272

<400> 272
000


<210> 273

<400> 273
000


<210> 274

<400> 274
000


<210> 275

<400> 275
000


<210> 276

<400> 276
000


<210> 277

<400> 277
000


<210> 278

<400> 278
000


<210> 279

<400> 279
000


<210> 280

<400> 280
000


<210> 281

<400> 281
000


<210> 282

<400> 282
000


<210> 283

<400> 283
000


<210> 284

<400> 284
000


<210> 285

<400> 285
000


<210> 286

<400> 286
000


<210> 287

<400> 287
000


<210> 288

<400> 288
000


<210> 289

<400> 289
000


<210> 290

<400> 290
000


<210> 291

<400> 291
000


<210> 292

<400> 292
000


<210> 293

<400> 293
000


<210> 294

<400> 294
000


<210> 295

<400> 295
000


<210> 296

<400> 296
000


<210> 297

<400> 297
000


<210> 298

<400> 298
000


<210> 299

<400> 299
000


<210> 300

<400> 300
000

<210>  301
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  301

Thr Val Ala Ala Pro Ser Gly 
1               5           


<210>  302
<211>  227
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  302

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  303
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  303

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


<210>  304
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  304

Gly Ser Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


<210>  305
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  305

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser 
            20                  


<210>  306
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  306

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Ser Ser 
            20                  


<210>  307
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  307

Glu Pro Lys Ser Ser Gly Ser Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Ser Ser 
            20                  


<210>  308
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  308

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser 
            


<210>  309
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  309

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Ser Ser 
            


<210>  310
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  310

Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro 
1               5                   10                  15      


Ser Ala Pro Ala 
            20  


<210>  311
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  311

Ala Ala Pro Ala Ser Pro Ala Pro Ala Ala Pro Ser Ala Pro Ala Pro 
1               5                   10                  15      


Ala Ala Pro Ser 
            20  


<210>  312
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  312

Ala Pro Ser Ser Pro Ser Pro Ser Ala Pro Ser Ser Pro Ser Pro Ala 
1               5                   10                  15      


Ser Pro Ser Ser 
            20  


<210>  313
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  313

Ser Ala Pro Ser Ser Pro Ser Pro Ser Ala Pro Ser Ser Pro Ser Pro 
1               5                   10                  15      


Ala Ser Pro Ser 
            20  


<210>  314
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  314

Ser Ser Pro Ser Ala Pro Ser Pro Ser Ser Pro Ala Ser Pro Ser Pro 
1               5                   10                  15      


Ser Ser Pro Ala 
            20  


<210>  315
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  315

Ala Ala Ser Pro Ala Ala Pro Ser Ala Pro Pro Ala Ala Ala Ser Pro 
1               5                   10                  15      


Ala Ala Pro Ser Ala Pro Pro Ala 
            20                  


<210>  316
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  316

Ala Ser Ala Ala Ala Pro Ala Ala Ala Ser Ala Ala Ala Ser Ala Pro 
1               5                   10                  15      


Ser Ala Ala Ala 
            20  


<210>  317
<211>  519
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  317
atgcatccta ttcctgattc ttctcctctg ctgcaatttg ggggtcaggt gcgccaacgt       60

tacctgtaca ccgacgatgc gcaacagact gaggctcacc tggagatccg tgaggacggg      120

actgtcggag gggctgccga tcaatcccca gagtcactgc tgcaactgaa agccctgaag      180

cctggggtca ttcagatcct gggcgtaaag acgagtcgtt tcctgtgcca acgtcctgac      240

ggggcactgt atggctcgct gcattttgat cctgaggctt gtagttttcg cgaactgctg      300

ctggaagatg gttacaatgt gtatcagagt gaagcacacg gtctgcctct gcacctgggt      360

tctggtcgtg gtccggcgcg ttttctgcca ctgcctggcc tgcctccagc accacctgaa      420

ccaccgggta ttctggctcc gcaacctcca gacgtcggga gttcagatcc tctgtcgatg      480

gtagaaccgt cacaaggtcg ctctcctagt tacgcgtca                             519


<210>  318
<211>  519
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  318
atgcatccta ttcctgattc ttctcctctg ctgcaatttg ggggtcaggt gcgccaacgt       60

tacctgtaca ccgacgatgc gcaacagact gaggctcacc tggagatccg tgaggacggg      120

actgtcggag gggctgccga tcaatcccca gagtcactgc tgcaactgaa agccctgaag      180

cctggggtca ttcagatcct gggcgtaaag acgagtcgtt tcctgtgcca acgtcctgac      240

ggggcactgt atggctcgct gcattttgat cctgaggctt gtagttttcg cgaactgctg      300

ctggaagatg gttacaatgt gtattagagt gaagcacacg gtctgcctct gcatctgggc      360

tccggccgcg gtccggcccg ttttctgcca ctgcctggcc tgcctccagc accacctgaa      420

ccaccgggta ttctggctcc gcaacctcca gacgtcggga gttcagatcc tctgtcgatg      480

gtagaaccgt cacaaggtcg ctctcctagt tacgcgtca                             519


<210>  319
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  319

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp His Ser Tyr Tyr Glu Gln Asn Ser Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu 
        35                  40                  45              


Phe Thr Val Pro Tyr Ser Gln Thr Thr Ala Thr Ile Ser Gly Leu Lys 
    50                  55                  60                  


Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Tyr Gly Ser Lys 
65                  70                  75                  80  


Tyr Tyr Tyr Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Glu Lys Pro 
                85                  90                  95      


Ser Gln 
        


<210>  320
<211>  103
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  320

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Arg Glu Val Gln Lys Tyr Ser Asp Leu Gly 
        35                  40                  45              


Pro Leu Tyr Ile Tyr Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr 
    50                  55                  60                  


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
65                  70                  75                  80  


Tyr Ala Val Thr Gly Ser Gly Glu Ser Pro Ala Ser Ser Lys Pro Ile 
                85                  90                  95      


Ser Ile Asn Tyr Arg Thr Pro 
            100             


<210>  321
<211>  585
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  321

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ala Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  322
<211>  584
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  322

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ala Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly 
            580                 


<210>  323
<211>  227
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  323

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  324
<211>  225
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  324

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro 
225 


<210>  325
<211>  227
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  325

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  326
<211>  227
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  326

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly 
1               5                   10                  15      


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  327
<211>  232
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  327

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  328
<211>  227
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  328

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  329
<211>  226
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  329

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210>  330
<211>  227
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  330

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  331
<211>  227
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  331

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ser Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  332
<211>  227
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  332

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  333
<211>  227
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  333

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr His Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  334
<211>  233
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  334

Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10                  15      


Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Leu Gly Lys 
225                 230             


<210>  335
<211>  233
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  335

Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Leu Gly Lys 
225                 230             


<210> 336

<400> 336
000


<210> 337

<400> 337
000


<210> 338

<400> 338
000


<210> 339

<400> 339
000


<210> 340

<400> 340
000


<210> 341

<400> 341
000


<210> 342

<400> 342
000

<210>  343
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  343

Gly Ser Gly His 
1               


<210>  344
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  344

His His Ser Gly 
1               


<210>  345
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  345

His Gly Ser His 
1               


<210>  346
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  346

Gly Ser Gly Pro 
1               


<210>  347
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  347

His Ser Gly Gly 
1               


<210>  348
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  348

His Gly Ser Gly 
1               


<210>  349
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  349

Lys Asp Ser Gln 
1               


<210>  350
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  350

Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25              


<210>  351
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  351

Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro Pro Ser Pro Glu Pro 
1               5                   10                  15  


<210>  352
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  352

Glu Leu Gln Leu Glu Glu Ser Ala Ala Glu Ala Gln Glu Gly Glu Leu 
1               5                   10                  15      


Glu 
    


<210>  353
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  353

Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Gly 
1               5                   10                  15      


Ser 
    


<210>  354
<211>  2
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  354

Gly Ser 
1       


<210>  355
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  355

Gly Gly Gly Gly Ser 
1               5   


<210>  356
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  356

Glu Glu Glu Glu Asp Glu Glu Glu Glu Asp 
1               5                   10  


<210>  357
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  357

Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro 
1               5                   10  


<210>  358
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  358

Gly Ser His His His His His His His His Gly Ser 
1               5                   10          


<210>  359
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  359

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  360
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  360

Gly Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  361
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  361

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


<210>  362
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  362

Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro Ser 
1               5                   10                  15      


Pro Ser 
        


<210>  363
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  363

Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln Glu 
1               5                   10                  15      


Glu Arg Glu Thr Lys Thr Pro 
            20              


<210>  364
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  364

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  365
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  365

Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro Pro Ser Pro Glu Pro Pro 
1               5                   10                  15      


Thr Pro Glu Pro Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro 
            20                  25                  30  


<210>  366
<211>  36
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  366

Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro Ser 
1               5                   10                  15      


Pro Ser Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr 
            20                  25                  30          


Pro Ser Pro Ser 
        35      


<210>  367
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  367

Pro Ser Pro Glu Pro 
1               5   


<210>  368
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  368

Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro Pro Ser Pro Glu Pro Pro 
1               5                   10                  15      


Thr Pro Glu Pro 
            20  


<210>  369
<211>  40
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  369

Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro Pro Ser Pro Glu Pro Pro 
1               5                   10                  15      


Thr Pro Glu Pro Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro Pro Ser 
            20                  25                  30          


Pro Glu Pro Pro Thr Pro Glu Pro 
        35                  40  


<210>  370
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  370

Pro Thr Pro Glu Pro Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro Pro 
1               5                   10                  15      


Ser Pro Glu Pro 
            20  


<210>  371
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  371

Pro Ser Pro Glu Pro Gly Gly Gly Ser Pro Thr Pro Glu Pro 
1               5                   10                  


<210>  372
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  372

Pro Ser Pro Glu Pro Glu Glu Glu Asp Pro Thr Pro Glu Pro 
1               5                   10                  


<210>  373
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  373

Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro Glu Glu Glu Asp Pro Ser 
1               5                   10                  15      


Pro Glu Pro Pro Thr Pro Glu Pro 
            20                  


<210>  374
<211>  34
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  374

Pro Thr Pro Glu Pro Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro Glu 
1               5                   10                  15      


Glu Glu Asp Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro Pro Ser Pro 
            20                  25                  30          


Glu Pro 
        


<210>  375
<211>  35
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  375

Pro Thr Pro Glu Pro Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro Gly 
1               5                   10                  15      


Gly Gly Gly Ser Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro Pro Ser 
            20                  25                  30          


Pro Glu Pro 
        35  


<210>  376
<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  376

Pro Ser Pro Glu Pro Thr Pro Glu Pro Ser Pro Glu Pro Pro Thr Pro 
1               5                   10                  15      


Glu Pro Ser Pro Glu Pro Thr Pro Glu Pro 
            20                  25      


<210>  377
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  377

Gly Glu Thr Gly Ser 
1               5   


<210>  378
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  378

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  379
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  379

Gly Glu Thr Gly Ser Ser Gly Glu Gly Thr 
1               5                   10  


<210>  380
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  380

Gly Glu Thr Gly Ser Ser Gly Glu Gly Thr Gly Ser Thr Gly Ser 
1               5                   10                  15  


<210>  381
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  381

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  382
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  382

Gly Glu Thr Gly Ser Ser Gly Glu Gly Thr Gly Ser Thr Gly Ser Gly 
1               5                   10                  15      


Ala Gly Glu Ser 
            20  


<210>  383
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  383

Gly Glu Thr Gly Ser Ser Gly Glu Gly Thr Gly Ser Thr Gly Ser Gly 
1               5                   10                  15      


Ala Gly Glu Ser Gly Thr Gly Glu Ser Gly Glu Gly Gly Ser 
            20                  25                  30  


<210> 384

<400> 384
000


<210> 385

<400> 385
000


<210> 386

<400> 386
000


<210> 387

<400> 387
000


<210> 388

<400> 388
000


<210> 389

<400> 389
000


<210> 390

<400> 390
000


<210> 391

<400> 391
000


<210> 392

<400> 392
000


<210> 393

<400> 393
000


<210> 394

<400> 394
000


<210> 395

<400> 395
000


<210> 396

<400> 396
000


<210> 397

<400> 397
000


<210> 398

<400> 398
000


<210> 399

<400> 399
000


<210> 400

<400> 400
000


<210>  401
<211>  277
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  401

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Arg Glu Val Gln Lys Tyr Ser Asp Leu Gly 
        35                  40                  45              


Pro Leu Tyr Ile Tyr Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr 
    50                  55                  60                  


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
65                  70                  75                  80  


Tyr Ala Val Thr Gly Ser Gly Glu Ser Pro Ala Ser Ser Lys Pro Ile 
                85                  90                  95      


Ser Ile Asn Tyr Arg Thr Pro Gly Ser His Pro Ile Pro Asp Ser Ser 
            100                 105                 110         


Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr 
        115                 120                 125             


Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly 
    130                 135                 140                 


Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu 
145                 150                 155                 160 


Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser 
                165                 170                 175     


Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His 
            180                 185                 190         


Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly 
        195                 200                 205             


Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Gly 
    210                 215                 220                 


Ser Gly Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 
225                 230                 235                 240 


Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 
                245                 250                 255     


Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser 
            260                 265                 270         


Pro Ser Tyr Ala Ser 
        275         


<210>  402
<211>  280
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  402

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Arg Glu Val Gln Lys Tyr Ser Asp Leu Gly 
        35                  40                  45              


Pro Leu Tyr Ile Tyr Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr 
    50                  55                  60                  


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
65                  70                  75                  80  


Tyr Ala Val Thr Gly Ser Gly Glu Ser Pro Ala Ser Ser Lys Pro Ile 
                85                  90                  95      


Ser Ile Asn Tyr Arg Thr Pro Gly Gly Gly Gly Ser His Pro Ile Pro 
            100                 105                 110         


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
        115                 120                 125             


Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 
    130                 135                 140                 


Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 
145                 150                 155                 160 


Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
                165                 170                 175     


Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 
            180                 185                 190         


Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 
        195                 200                 205             


Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 
    210                 215                 220                 


His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 
225                 230                 235                 240 


Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 
                245                 250                 255     


Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln 
            260                 265                 270         


Gly Arg Ser Pro Ser Tyr Ala Ser 
        275                 280 


<210>  403
<211>  285
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  403

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Arg Glu Val Gln Lys Tyr Ser Asp Leu Gly 
        35                  40                  45              


Pro Leu Tyr Ile Tyr Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr 
    50                  55                  60                  


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
65                  70                  75                  80  


Tyr Ala Val Thr Gly Ser Gly Glu Ser Pro Ala Ser Ser Lys Pro Ile 
                85                  90                  95      


Ser Ile Asn Tyr Arg Thr Pro Glu Glu Glu Glu Asp Glu Glu Glu Glu 
            100                 105                 110         


Asp His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
        115                 120                 125             


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
    130                 135                 140                 


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
145                 150                 155                 160 


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
                165                 170                 175     


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
            180                 185                 190         


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
        195                 200                 205             


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
    210                 215                 220                 


His Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe 
225                 230                 235                 240 


Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile 
                245                 250                 255     


Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met 
            260                 265                 270         


Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
        275                 280                 285 


<210>  404
<211>  285
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  404

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Arg Glu Val Gln Lys Tyr Ser Asp Leu Gly 
        35                  40                  45              


Pro Leu Tyr Ile Tyr Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr 
    50                  55                  60                  


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
65                  70                  75                  80  


Tyr Ala Val Thr Gly Ser Gly Glu Ser Pro Ala Ser Ser Lys Pro Ile 
                85                  90                  95      


Ser Ile Asn Tyr Arg Thr Pro Pro Ser Pro Glu Pro Pro Thr Pro Glu 
            100                 105                 110         


Pro His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
        115                 120                 125             


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
    130                 135                 140                 


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
145                 150                 155                 160 


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
                165                 170                 175     


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
            180                 185                 190         


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
        195                 200                 205             


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
    210                 215                 220                 


His Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe 
225                 230                 235                 240 


Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile 
                245                 250                 255     


Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met 
            260                 265                 270         


Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
        275                 280                 285 


<210>  405
<211>  287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  405

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Arg Glu Val Gln Lys Tyr Ser Asp Leu Gly 
        35                  40                  45              


Pro Leu Tyr Ile Tyr Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr 
    50                  55                  60                  


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
65                  70                  75                  80  


Tyr Ala Val Thr Gly Ser Gly Glu Ser Pro Ala Ser Ser Lys Pro Ile 
                85                  90                  95      


Ser Ile Asn Tyr Arg Thr Pro Gly Ser His His His His His His His 
            100                 105                 110         


His Gly Ser His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly 
        115                 120                 125             


Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr 
    130                 135                 140                 


Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala 
145                 150                 155                 160 


Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly 
                165                 170                 175     


Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg 
            180                 185                 190         


Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys 
        195                 200                 205             


Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser 
    210                 215                 220                 


Glu Ala His Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala 
225                 230                 235                 240 


Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro 
                245                 250                 255     


Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu 
            260                 265                 270         


Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
        275                 280                 285         


<210>  406
<211>  290
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  406

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Arg Glu Val Gln Lys Tyr Ser Asp Leu Gly 
        35                  40                  45              


Pro Leu Tyr Ile Tyr Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr 
    50                  55                  60                  


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
65                  70                  75                  80  


Tyr Ala Val Thr Gly Ser Gly Glu Ser Pro Ala Ser Ser Lys Pro Ile 
                85                  90                  95      


Ser Ile Asn Tyr Arg Thr Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser His Pro Ile Pro Asp Ser Ser Pro Leu Leu 
        115                 120                 125             


Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala 
    130                 135                 140                 


Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly 
145                 150                 155                 160 


Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu 
                165                 170                 175     


Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu 
            180                 185                 190         


Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro 
        195                 200                 205             


Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val 
    210                 215                 220                 


Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Gly Ser Gly Arg 
225                 230                 235                 240 


Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro 
                245                 250                 255     


Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser 
            260                 265                 270         


Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr 
        275                 280                 285             


Ala Ser 
    290 


<210>  407
<211>  290
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  407

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Arg Glu Val Gln Lys Tyr Ser Asp Leu Gly 
        35                  40                  45              


Pro Leu Tyr Ile Tyr Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr 
    50                  55                  60                  


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
65                  70                  75                  80  


Tyr Ala Val Thr Gly Ser Gly Glu Ser Pro Ala Ser Ser Lys Pro Ile 
                85                  90                  95      


Ser Ile Asn Tyr Arg Thr Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser His Pro Ile Pro Asp Ser Ser Pro Leu Leu 
        115                 120                 125             


Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala 
    130                 135                 140                 


Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly 
145                 150                 155                 160 


Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu 
                165                 170                 175     


Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu 
            180                 185                 190         


Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro 
        195                 200                 205             


Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val 
    210                 215                 220                 


Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Gly Ser Gly Arg 
225                 230                 235                 240 


Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro 
                245                 250                 255     


Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser 
            260                 265                 270         


Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr 
        275                 280                 285             


Ala Ser 
    290 


<210>  408
<211>  291
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  408

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Arg Glu Val Gln Lys Tyr Ser Asp Leu Gly 
        35                  40                  45              


Pro Leu Tyr Ile Tyr Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr 
    50                  55                  60                  


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
65                  70                  75                  80  


Tyr Ala Val Thr Gly Ser Gly Glu Ser Pro Ala Ser Ser Lys Pro Ile 
                85                  90                  95      


Ser Ile Asn Tyr Arg Thr Pro Gly Ser Gly Ser Gly Ser Gly Ser Gly 
            100                 105                 110         


Ser Gly Ser Gly Ser Gly Ser His Pro Ile Pro Asp Ser Ser Pro Leu 
        115                 120                 125             


Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp 
    130                 135                 140                 


Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val 
145                 150                 155                 160 


Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala 
                165                 170                 175     


Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe 
            180                 185                 190         


Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp 
        195                 200                 205             


Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn 
    210                 215                 220                 


Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Gly Ser Gly 
225                 230                 235                 240 


Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro 
                245                 250                 255     


Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser 
            260                 265                 270         


Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser 
        275                 280                 285             


Tyr Ala Ser 
    290     


<210>  409
<211>  293
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  409

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Arg Glu Val Gln Lys Tyr Ser Asp Leu Gly 
        35                  40                  45              


Pro Leu Tyr Ile Tyr Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr 
    50                  55                  60                  


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
65                  70                  75                  80  


Tyr Ala Val Thr Gly Ser Gly Glu Ser Pro Ala Ser Ser Lys Pro Ile 
                85                  90                  95      


Ser Ile Asn Tyr Arg Thr Pro Pro Ser Thr Pro Pro Thr Pro Ser Pro 
            100                 105                 110         


Ser Thr Pro Pro Thr Pro Ser Pro Ser His Pro Ile Pro Asp Ser Ser 
        115                 120                 125             


Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr 
    130                 135                 140                 


Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly 
145                 150                 155                 160 


Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu 
                165                 170                 175     


Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser 
            180                 185                 190         


Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His 
        195                 200                 205             


Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly 
    210                 215                 220                 


Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Gly 
225                 230                 235                 240 


Ser Gly Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 
                245                 250                 255     


Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 
            260                 265                 270         


Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser 
        275                 280                 285             


Pro Ser Tyr Ala Ser 
    290             


<210>  410
<211>  298
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  410

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Arg Glu Val Gln Lys Tyr Ser Asp Leu Gly 
        35                  40                  45              


Pro Leu Tyr Ile Tyr Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr 
    50                  55                  60                  


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
65                  70                  75                  80  


Tyr Ala Val Thr Gly Ser Gly Glu Ser Pro Ala Ser Ser Lys Pro Ile 
                85                  90                  95      


Ser Ile Asn Tyr Arg Thr Pro Arg Gly Gly Glu Glu Lys Lys Lys Glu 
            100                 105                 110         


Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro His Pro 
        115                 120                 125             


Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln 
    130                 135                 140                 


Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu 
145                 150                 155                 160 


Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu 
                165                 170                 175     


Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu 
            180                 185                 190         


Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu 
        195                 200                 205             


Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu 
    210                 215                 220                 


Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu 
225                 230                 235                 240 


Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu Pro Leu 
                245                 250                 255     


Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 
            260                 265                 270         


Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro 
        275                 280                 285             


Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
    290                 295             


<210>  411
<211>  300
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  411

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Arg Glu Val Gln Lys Tyr Ser Asp Leu Gly 
        35                  40                  45              


Pro Leu Tyr Ile Tyr Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr 
    50                  55                  60                  


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
65                  70                  75                  80  


Tyr Ala Val Thr Gly Ser Gly Glu Ser Pro Ala Ser Ser Lys Pro Ile 
                85                  90                  95      


Ser Ile Asn Tyr Arg Thr Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
    130                 135                 140                 


Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 
145                 150                 155                 160 


Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 
                165                 170                 175     


Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 
            180                 185                 190         


Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 
        195                 200                 205             


Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 
    210                 215                 220                 


Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 
225                 230                 235                 240 


Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu 
                245                 250                 255     


Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu 
            260                 265                 270         


Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val 
        275                 280                 285             


Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
    290                 295                 300 


<210>  412
<211>  305
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  412

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Arg Glu Val Gln Lys Tyr Ser Asp Leu Gly 
        35                  40                  45              


Pro Leu Tyr Ile Tyr Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr 
    50                  55                  60                  


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
65                  70                  75                  80  


Tyr Ala Val Thr Gly Ser Gly Glu Ser Pro Ala Ser Ser Lys Pro Ile 
                85                  90                  95      


Ser Ile Asn Tyr Arg Thr Pro Pro Ser Pro Glu Pro Pro Thr Pro Glu 
            100                 105                 110         


Pro Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro Pro Ser Pro Glu Pro 
        115                 120                 125             


Pro Thr Pro Glu Pro His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 
    130                 135                 140                 


Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln 
145                 150                 155                 160 


Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 
                165                 170                 175     


Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 
            180                 185                 190         


Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 
        195                 200                 205             


Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 
    210                 215                 220                 


Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 
225                 230                 235                 240 


Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly 
                245                 250                 255     


Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu 
            260                 265                 270         


Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp 
        275                 280                 285             


Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
    290                 295                 300                 


Ser 
305 


<210>  413
<211>  311
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  413

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Arg Glu Val Gln Lys Tyr Ser Asp Leu Gly 
        35                  40                  45              


Pro Leu Tyr Ile Tyr Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr 
    50                  55                  60                  


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
65                  70                  75                  80  


Tyr Ala Val Thr Gly Ser Gly Glu Ser Pro Ala Ser Ser Lys Pro Ile 
                85                  90                  95      


Ser Ile Asn Tyr Arg Thr Pro Pro Ser Thr Pro Pro Thr Pro Ser Pro 
            100                 105                 110         


Ser Thr Pro Pro Thr Pro Ser Pro Ser Pro Ser Thr Pro Pro Thr Pro 
        115                 120                 125             


Ser Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser His Pro Ile Pro Asp 
    130                 135                 140                 


Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu 
145                 150                 155                 160 


Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu 
                165                 170                 175     


Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu 
            180                 185                 190         


Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys 
        195                 200                 205             


Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser 
    210                 215                 220                 


Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu 
225                 230                 235                 240 


Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His 
                245                 250                 255     


Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu 
            260                 265                 270         


Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro 
        275                 280                 285             


Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly 
    290                 295                 300                 


Arg Ser Pro Ser Tyr Ala Ser 
305                 310     


<210>  414
<211>  280
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  414

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Arg Glu Val Gln Lys Tyr Ser Asp Leu Gly 
        35                  40                  45              


Pro Leu Tyr Ile Tyr Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr 
    50                  55                  60                  


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
65                  70                  75                  80  


Tyr Ala Val Thr Gly Ser Gly Glu Ser Pro Ala Ser Ser Lys Pro Ile 
                85                  90                  95      


Ser Ile Asn Tyr Arg Thr Pro Pro Ser Pro Glu Pro His Pro Ile Pro 
            100                 105                 110         


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
        115                 120                 125             


Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 
    130                 135                 140                 


Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 
145                 150                 155                 160 


Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
                165                 170                 175     


Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 
            180                 185                 190         


Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 
        195                 200                 205             


Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 
    210                 215                 220                 


His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 
225                 230                 235                 240 


Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 
                245                 250                 255     


Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln 
            260                 265                 270         


Gly Arg Ser Pro Ser Tyr Ala Ser 
        275                 280 


<210>  415
<211>  295
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  415

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Arg Glu Val Gln Lys Tyr Ser Asp Leu Gly 
        35                  40                  45              


Pro Leu Tyr Ile Tyr Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr 
    50                  55                  60                  


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
65                  70                  75                  80  


Tyr Ala Val Thr Gly Ser Gly Glu Ser Pro Ala Ser Ser Lys Pro Ile 
                85                  90                  95      


Ser Ile Asn Tyr Arg Thr Pro Pro Ser Pro Glu Pro Pro Thr Pro Glu 
            100                 105                 110         


Pro Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro His Pro Ile Pro Asp 
        115                 120                 125             


Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu 
    130                 135                 140                 


Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu 
145                 150                 155                 160 


Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu 
                165                 170                 175     


Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys 
            180                 185                 190         


Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser 
        195                 200                 205             


Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu 
    210                 215                 220                 


Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His 
225                 230                 235                 240 


Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu 
                245                 250                 255     


Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro 
            260                 265                 270         


Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly 
        275                 280                 285             


Arg Ser Pro Ser Tyr Ala Ser 
    290                 295 


<210>  416
<211>  315
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  416

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Arg Glu Val Gln Lys Tyr Ser Asp Leu Gly 
        35                  40                  45              


Pro Leu Tyr Ile Tyr Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr 
    50                  55                  60                  


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
65                  70                  75                  80  


Tyr Ala Val Thr Gly Ser Gly Glu Ser Pro Ala Ser Ser Lys Pro Ile 
                85                  90                  95      


Ser Ile Asn Tyr Arg Thr Pro Pro Ser Pro Glu Pro Pro Thr Pro Glu 
            100                 105                 110         


Pro Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro Pro Ser Pro Glu Pro 
        115                 120                 125             


Pro Thr Pro Glu Pro Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro His 
    130                 135                 140                 


Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg 
145                 150                 155                 160 


Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu 
                165                 170                 175     


Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro 
            180                 185                 190         


Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile 
        195                 200                 205             


Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala 
    210                 215                 220                 


Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu 
225                 230                 235                 240 


Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly 
                245                 250                 255     


Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu Pro 
            260                 265                 270         


Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala 
        275                 280                 285             


Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu 
    290                 295                 300                 


Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
305                 310                 315 


<210>  417
<211>  295
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  417

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Arg Glu Val Gln Lys Tyr Ser Asp Leu Gly 
        35                  40                  45              


Pro Leu Tyr Ile Tyr Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr 
    50                  55                  60                  


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
65                  70                  75                  80  


Tyr Ala Val Thr Gly Ser Gly Glu Ser Pro Ala Ser Ser Lys Pro Ile 
                85                  90                  95      


Ser Ile Asn Tyr Arg Thr Pro Pro Thr Pro Glu Pro Pro Ser Pro Glu 
            100                 105                 110         


Pro Pro Thr Pro Glu Pro Pro Ser Pro Glu Pro His Pro Ile Pro Asp 
        115                 120                 125             


Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu 
    130                 135                 140                 


Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu 
145                 150                 155                 160 


Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu 
                165                 170                 175     


Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys 
            180                 185                 190         


Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser 
        195                 200                 205             


Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu 
    210                 215                 220                 


Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His 
225                 230                 235                 240 


Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu 
                245                 250                 255     


Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro 
            260                 265                 270         


Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly 
        275                 280                 285             


Arg Ser Pro Ser Tyr Ala Ser 
    290                 295 


<210>  418
<211>  289
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  418

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Arg Glu Val Gln Lys Tyr Ser Asp Leu Gly 
        35                  40                  45              


Pro Leu Tyr Ile Tyr Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr 
    50                  55                  60                  


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
65                  70                  75                  80  


Tyr Ala Val Thr Gly Ser Gly Glu Ser Pro Ala Ser Ser Lys Pro Ile 
                85                  90                  95      


Ser Ile Asn Tyr Arg Thr Pro Pro Ser Pro Glu Pro Gly Gly Gly Ser 
            100                 105                 110         


Pro Thr Pro Glu Pro His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 
        115                 120                 125             


Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln 
    130                 135                 140                 


Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 
145                 150                 155                 160 


Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 
                165                 170                 175     


Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 
            180                 185                 190         


Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 
        195                 200                 205             


Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 
    210                 215                 220                 


Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly 
225                 230                 235                 240 


Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu 
                245                 250                 255     


Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp 
            260                 265                 270         


Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
        275                 280                 285             


Ser 
    


<210>  419
<211>  289
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  419

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Arg Glu Val Gln Lys Tyr Ser Asp Leu Gly 
        35                  40                  45              


Pro Leu Tyr Ile Tyr Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr 
    50                  55                  60                  


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
65                  70                  75                  80  


Tyr Ala Val Thr Gly Ser Gly Glu Ser Pro Ala Ser Ser Lys Pro Ile 
                85                  90                  95      


Ser Ile Asn Tyr Arg Thr Pro Pro Ser Pro Glu Pro Glu Glu Glu Asp 
            100                 105                 110         


Pro Thr Pro Glu Pro His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 
        115                 120                 125             


Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln 
    130                 135                 140                 


Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 
145                 150                 155                 160 


Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 
                165                 170                 175     


Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 
            180                 185                 190         


Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 
        195                 200                 205             


Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 
    210                 215                 220                 


Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly 
225                 230                 235                 240 


Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu 
                245                 250                 255     


Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp 
            260                 265                 270         


Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
        275                 280                 285             


Ser 
    


<210>  420
<211>  299
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  420

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Arg Glu Val Gln Lys Tyr Ser Asp Leu Gly 
        35                  40                  45              


Pro Leu Tyr Ile Tyr Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr 
    50                  55                  60                  


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
65                  70                  75                  80  


Tyr Ala Val Thr Gly Ser Gly Glu Ser Pro Ala Ser Ser Lys Pro Ile 
                85                  90                  95      


Ser Ile Asn Tyr Arg Thr Pro Pro Ser Pro Glu Pro Pro Thr Pro Glu 
            100                 105                 110         


Pro Glu Glu Glu Asp Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro His 
        115                 120                 125             


Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg 
    130                 135                 140                 


Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu 
145                 150                 155                 160 


Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro 
                165                 170                 175     


Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile 
            180                 185                 190         


Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala 
        195                 200                 205             


Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu 
    210                 215                 220                 


Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly 
225                 230                 235                 240 


Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu Pro 
                245                 250                 255     


Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala 
            260                 265                 270         


Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu 
        275                 280                 285             


Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
    290                 295                 


<210>  421
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  421

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Arg Glu Val Gln Lys Tyr Ser Asp Leu Gly 
        35                  40                  45              


Pro Leu Tyr Ile Tyr Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr 
    50                  55                  60                  


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
65                  70                  75                  80  


Tyr Ala Val Thr Gly Ser Gly Glu Ser Pro Ala Ser Ser Lys Pro Ile 
                85                  90                  95      


Ser Ile Asn Tyr Arg Thr Pro Pro Thr Pro Glu Pro Pro Ser Pro Glu 
            100                 105                 110         


Pro Pro Thr Pro Glu Pro Glu Glu Glu Asp Pro Ser Pro Glu Pro Pro 
        115                 120                 125             


Thr Pro Glu Pro Pro Ser Pro Glu Pro His Pro Ile Pro Asp Ser Ser 
    130                 135                 140                 


Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr 
145                 150                 155                 160 


Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly 
                165                 170                 175     


Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu 
            180                 185                 190         


Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser 
        195                 200                 205             


Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His 
    210                 215                 220                 


Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly 
225                 230                 235                 240 


Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Gly 
                245                 250                 255     


Ser Gly Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 
            260                 265                 270         


Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 
        275                 280                 285             


Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser 
    290                 295                 300                 


Pro Ser Tyr Ala Ser 
305                 


<210>  422
<211>  310
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  422

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Arg Glu Val Gln Lys Tyr Ser Asp Leu Gly 
        35                  40                  45              


Pro Leu Tyr Ile Tyr Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr 
    50                  55                  60                  


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
65                  70                  75                  80  


Tyr Ala Val Thr Gly Ser Gly Glu Ser Pro Ala Ser Ser Lys Pro Ile 
                85                  90                  95      


Ser Ile Asn Tyr Arg Thr Pro Pro Thr Pro Glu Pro Pro Ser Pro Glu 
            100                 105                 110         


Pro Pro Thr Pro Glu Pro Gly Gly Gly Gly Ser Pro Ser Pro Glu Pro 
        115                 120                 125             


Pro Thr Pro Glu Pro Pro Ser Pro Glu Pro His Pro Ile Pro Asp Ser 
    130                 135                 140                 


Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr 
145                 150                 155                 160 


Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp 
                165                 170                 175     


Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln 
            180                 185                 190         


Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr 
        195                 200                 205             


Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu 
    210                 215                 220                 


His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp 
225                 230                 235                 240 


Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu 
                245                 250                 255     


Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro 
            260                 265                 270         


Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp 
        275                 280                 285             


Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg 
    290                 295                 300                 


Ser Pro Ser Tyr Ala Ser 
305                 310 


<210>  423
<211>  301
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  423

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Arg Glu Val Gln Lys Tyr Ser Asp Leu Gly 
        35                  40                  45              


Pro Leu Tyr Ile Tyr Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr 
    50                  55                  60                  


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
65                  70                  75                  80  


Tyr Ala Val Thr Gly Ser Gly Glu Ser Pro Ala Ser Ser Lys Pro Ile 
                85                  90                  95      


Ser Ile Asn Tyr Arg Thr Pro Pro Ser Pro Glu Pro Thr Pro Glu Pro 
            100                 105                 110         


Ser Pro Glu Pro Pro Thr Pro Glu Pro Ser Pro Glu Pro Thr Pro Glu 
        115                 120                 125             


Pro His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
    130                 135                 140                 


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
145                 150                 155                 160 


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
                165                 170                 175     


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
            180                 185                 190         


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
        195                 200                 205             


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
    210                 215                 220                 


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
225                 230                 235                 240 


His Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe 
                245                 250                 255     


Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile 
            260                 265                 270         


Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met 
        275                 280                 285             


Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
    290                 295                 300     


<210>  424
<211>  759
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  424

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ala Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Ser His Pro Ile Pro Asp 
            580                 585                 590         


Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu 
        595                 600                 605             


Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu 
    610                 615                 620                 


Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu 
625                 630                 635                 640 


Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys 
                645                 650                 655     


Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser 
            660                 665                 670         


Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu 
        675                 680                 685             


Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His 
    690                 695                 700                 


Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu 
705                 710                 715                 720 


Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro 
                725                 730                 735     


Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Glu 
            740                 745                 750         


Arg Ser Pro Ser Tyr Ala Ser 
        755                 


<210>  425
<211>  762
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  425

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ala Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly Ser His Pro 
            580                 585                 590         


Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln 
        595                 600                 605             


Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu 
    610                 615                 620                 


Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu 
625                 630                 635                 640 


Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu 
                645                 650                 655     


Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu 
            660                 665                 670         


Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu 
        675                 680                 685             


Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu 
    690                 695                 700                 


Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu Pro Leu 
705                 710                 715                 720 


Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 
                725                 730                 735     


Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro 
            740                 745                 750         


Ser Gln Glu Arg Ser Pro Ser Tyr Ala Ser 
        755                 760         


<210>  426
<211>  762
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  426

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ala Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Glu Thr Gly Ser His Pro 
            580                 585                 590         


Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln 
        595                 600                 605             


Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu 
    610                 615                 620                 


Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu 
625                 630                 635                 640 


Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu 
                645                 650                 655     


Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu 
            660                 665                 670         


Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu 
        675                 680                 685             


Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu 
    690                 695                 700                 


Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu Pro Leu 
705                 710                 715                 720 


Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 
                725                 730                 735     


Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro 
            740                 745                 750         


Ser Gln Glu Arg Ser Pro Ser Tyr Ala Ser 
        755                 760         


<210>  427
<211>  767
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  427

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ala Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly Ser Gly Gly 
            580                 585                 590         


Gly Gly Ser His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly 
        595                 600                 605             


Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr 
    610                 615                 620                 


Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala 
625                 630                 635                 640 


Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly 
                645                 650                 655     


Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg 
            660                 665                 670         


Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys 
        675                 680                 685             


Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser 
    690                 695                 700                 


Glu Ala His Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala 
705                 710                 715                 720 


Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro 
                725                 730                 735     


Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu 
            740                 745                 750         


Ser Met Val Glu Pro Ser Gln Glu Arg Ser Pro Ser Tyr Ala Ser 
        755                 760                 765         


<210>  428
<211>  767
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  428

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ala Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Glu Thr Gly Ser Ser Gly 
            580                 585                 590         


Glu Gly Thr His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly 
        595                 600                 605             


Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr 
    610                 615                 620                 


Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala 
625                 630                 635                 640 


Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly 
                645                 650                 655     


Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg 
            660                 665                 670         


Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys 
        675                 680                 685             


Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser 
    690                 695                 700                 


Glu Ala His Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala 
705                 710                 715                 720 


Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro 
                725                 730                 735     


Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu 
            740                 745                 750         


Ser Met Val Glu Pro Ser Gln Glu Arg Ser Pro Ser Tyr Ala Ser 
        755                 760                 765         


<210>  429
<211>  772
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  429

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ala Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly Ser Gly Gly 
            580                 585                 590         


Gly Gly Ser Gly Gly Gly Gly Ser His Pro Ile Pro Asp Ser Ser Pro 
        595                 600                 605             


Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp 
    610                 615                 620                 


Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr 
625                 630                 635                 640 


Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys 
                645                 650                 655     


Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg 
            660                 665                 670         


Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe 
        675                 680                 685             


Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr 
    690                 695                 700                 


Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Gly Ser 
705                 710                 715                 720 


Gly Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala 
                725                 730                 735     


Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly 
            740                 745                 750         


Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Glu Arg Ser Pro 
        755                 760                 765             


Ser Tyr Ala Ser 
    770         


<210>  430
<211>  772
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  430

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ala Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Glu Thr Gly Ser Ser Gly 
            580                 585                 590         


Glu Gly Thr Gly Ser Thr Gly Ser His Pro Ile Pro Asp Ser Ser Pro 
        595                 600                 605             


Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp 
    610                 615                 620                 


Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr 
625                 630                 635                 640 


Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys 
                645                 650                 655     


Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg 
            660                 665                 670         


Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe 
        675                 680                 685             


Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr 
    690                 695                 700                 


Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Gly Ser 
705                 710                 715                 720 


Gly Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala 
                725                 730                 735     


Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly 
            740                 745                 750         


Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Glu Arg Ser Pro 
        755                 760                 765             


Ser Tyr Ala Ser 
    770         


<210>  431
<211>  777
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  431

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ala Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly Ser Gly Gly 
            580                 585                 590         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Pro Ile 
        595                 600                 605             


Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg 
    610                 615                 620                 


Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile 
625                 630                 635                 640 


Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser 
                645                 650                 655     


Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly 
            660                 665                 670         


Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr 
        675                 680                 685             


Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu 
    690                 695                 700                 


Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro 
705                 710                 715                 720 


Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro 
                725                 730                 735     


Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln 
            740                 745                 750         


Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser 
        755                 760                 765             


Gln Glu Arg Ser Pro Ser Tyr Ala Ser 
    770                 775         


<210>  432
<211>  777
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  432

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ala Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Glu Thr Gly Ser Ser Gly 
            580                 585                 590         


Glu Gly Thr Gly Ser Thr Gly Ser Gly Ala Gly Glu Ser His Pro Ile 
        595                 600                 605             


Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg 
    610                 615                 620                 


Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile 
625                 630                 635                 640 


Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser 
                645                 650                 655     


Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly 
            660                 665                 670         


Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr 
        675                 680                 685             


Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu 
    690                 695                 700                 


Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro 
705                 710                 715                 720 


Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro 
                725                 730                 735     


Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln 
            740                 745                 750         


Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser 
        755                 760                 765             


Gln Glu Arg Ser Pro Ser Tyr Ala Ser 
    770                 775         


<210> 433

<400> 433
000


<210>  434
<211>  771
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  434

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ala Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly 
            580                 585                 590         


Gly Ser Gly Gly Gly Gly Ser His Pro Ile Pro Asp Ser Ser Pro Leu 
        595                 600                 605             


Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp 
    610                 615                 620                 


Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val 
625                 630                 635                 640 


Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala 
                645                 650                 655     


Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe 
            660                 665                 670         


Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp 
        675                 680                 685             


Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn 
    690                 695                 700                 


Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Gly Ser Gly 
705                 710                 715                 720 


Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro 
                725                 730                 735     


Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser 
            740                 745                 750         


Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Glu Arg Ser Pro Ser 
        755                 760                 765             


Tyr Ala Ser 
    770     


<210>  435
<211>  771
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  435

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ala Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Gly Glu Thr Gly Ser Ser Gly Glu 
            580                 585                 590         


Gly Thr Gly Ser Thr Gly Ser His Pro Ile Pro Asp Ser Ser Pro Leu 
        595                 600                 605             


Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp 
    610                 615                 620                 


Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val 
625                 630                 635                 640 


Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala 
                645                 650                 655     


Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe 
            660                 665                 670         


Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp 
        675                 680                 685             


Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn 
    690                 695                 700                 


Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Gly Ser Gly 
705                 710                 715                 720 


Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro 
                725                 730                 735     


Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser 
            740                 745                 750         


Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Glu Arg Ser Pro Ser 
        755                 760                 765             


Tyr Ala Ser 
    770     


<210>  436
<211>  780
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  436

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ala Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly 
            580                 585                 590         


Gly Ser Gly Gly Gly Gly Ser His Pro Ile Pro Asp Ser Ser Pro Leu 
        595                 600                 605             


Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp 
    610                 615                 620                 


Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val 
625                 630                 635                 640 


Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala 
                645                 650                 655     


Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe 
            660                 665                 670         


Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp 
        675                 680                 685             


Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn 
    690                 695                 700                 


Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn 
705                 710                 715                 720 


Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu 
                725                 730                 735     


Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu 
            740                 745                 750         


Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val 
        755                 760                 765             


Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
    770                 775                 780 


<210>  437
<211>  780
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  437

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ala Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Gly Glu Thr Gly Ser Ser Gly Glu 
            580                 585                 590         


Gly Thr Gly Ser Thr Gly Ser His Pro Ile Pro Asp Ser Ser Pro Leu 
        595                 600                 605             


Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp 
    610                 615                 620                 


Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val 
625                 630                 635                 640 


Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala 
                645                 650                 655     


Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe 
            660                 665                 670         


Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp 
        675                 680                 685             


Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn 
    690                 695                 700                 


Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn 
705                 710                 715                 720 


Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu 
                725                 730                 735     


Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu 
            740                 745                 750         


Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val 
        755                 760                 765             


Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
    770                 775                 780 


<210> 438

<400> 438
000


<210> 439

<400> 439
000

<210>  440
<211>  767
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  440

His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
1               5                   10                  15      


Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 
            20                  25                  30          


Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 
        35                  40                  45              


Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 
    50                  55                  60                  


Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 
65                  70                  75                  80  


Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 
                85                  90                  95      


Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 
            100                 105                 110         


Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu 
        115                 120                 125             


Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu 
    130                 135                 140                 


Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val 
145                 150                 155                 160 


Glu Pro Ser Gln Glu Arg Ser Pro Ser Tyr Ala Ser Gly Glu Thr Gly 
                165                 170                 175     


Ser Ser Gly Glu Gly Thr Asp Ala His Lys Ser Glu Val Ala His Arg 
            180                 185                 190         


Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala 
        195                 200                 205             


Phe Ala Gln Tyr Leu Gln Gln Ala Pro Phe Glu Asp His Val Lys Leu 
    210                 215                 220                 


Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser 
225                 230                 235                 240 


Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu 
                245                 250                 255     


Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys 
            260                 265                 270         


Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys 
        275                 280                 285             


Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val 
    290                 295                 300                 


Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr 
305                 310                 315                 320 


Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu 
                325                 330                 335     


Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln 
            340                 345                 350         


Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg 
        355                 360                 365             


Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser 
    370                 375                 380                 


Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg 
385                 390                 395                 400 


Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu 
                405                 410                 415     


Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu 
            420                 425                 430         


Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu 
        435                 440                 445             


Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro 
    450                 455                 460                 


Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met 
465                 470                 475                 480 


Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp 
                485                 490                 495     


Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe 
            500                 505                 510         


Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu 
        515                 520                 525             


Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala 
    530                 535                 540                 


Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys 
545                 550                 555                 560 


Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu 
                565                 570                 575     


Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg 
            580                 585                 590         


Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val 
        595                 600                 605             


Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu 
    610                 615                 620                 


Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn 
625                 630                 635                 640 


Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr 
                645                 650                 655     


Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala 
            660                 665                 670         


Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr 
        675                 680                 685             


Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln 
    690                 695                 700                 


Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys 
705                 710                 715                 720 


Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe 
                725                 730                 735     


Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu 
            740                 745                 750         


Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
        755                 760                 765         


<210>  441
<211>  777
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  441

His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
1               5                   10                  15      


Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 
            20                  25                  30          


Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 
        35                  40                  45              


Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 
    50                  55                  60                  


Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 
65                  70                  75                  80  


Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 
                85                  90                  95      


Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 
            100                 105                 110         


Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu 
        115                 120                 125             


Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu 
    130                 135                 140                 


Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val 
145                 150                 155                 160 


Glu Pro Ser Gln Glu Arg Ser Pro Ser Tyr Ala Ser Gly Glu Thr Gly 
                165                 170                 175     


Ser Ser Gly Glu Gly Thr Gly Ser Thr Gly Ser Gly Ala Gly Glu Ser 
            180                 185                 190         


Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
        195                 200                 205             


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
    210                 215                 220                 


Gln Ala Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
225                 230                 235                 240 


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
                245                 250                 255     


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
            260                 265                 270         


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
        275                 280                 285             


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
    290                 295                 300                 


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
305                 310                 315                 320 


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
                325                 330                 335     


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
            340                 345                 350         


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
        355                 360                 365             


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
    370                 375                 380                 


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
385                 390                 395                 400 


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
                405                 410                 415     


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
            420                 425                 430         


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
        435                 440                 445             


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
    450                 455                 460                 


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
465                 470                 475                 480 


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
                485                 490                 495     


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
            500                 505                 510         


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
        515                 520                 525             


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
    530                 535                 540                 


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
545                 550                 555                 560 


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
                565                 570                 575     


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
            580                 585                 590         


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
        595                 600                 605             


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
    610                 615                 620                 


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
625                 630                 635                 640 


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
                645                 650                 655     


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
            660                 665                 670         


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
        675                 680                 685             


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
    690                 695                 700                 


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
705                 710                 715                 720 


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
                725                 730                 735     


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
            740                 745                 750         


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
        755                 760                 765             


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
    770                 775         


<210>  442
<211>  787
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  442

His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
1               5                   10                  15      


Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 
            20                  25                  30          


Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 
        35                  40                  45              


Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 
    50                  55                  60                  


Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 
65                  70                  75                  80  


Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 
                85                  90                  95      


Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 
            100                 105                 110         


Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu 
        115                 120                 125             


Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu 
    130                 135                 140                 


Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val 
145                 150                 155                 160 


Glu Pro Ser Gln Glu Arg Ser Pro Ser Tyr Ala Ser Gly Glu Thr Gly 
                165                 170                 175     


Ser Ser Gly Glu Gly Thr Gly Ser Thr Gly Ser Gly Ala Gly Glu Ser 
            180                 185                 190         


Gly Thr Gly Glu Ser Gly Glu Gly Gly Ser Asp Ala His Lys Ser Glu 
        195                 200                 205             


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
    210                 215                 220                 


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ala Pro Phe Glu Asp 
225                 230                 235                 240 


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
                245                 250                 255     


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
            260                 265                 270         


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
        275                 280                 285             


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
    290                 295                 300                 


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
305                 310                 315                 320 


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
                325                 330                 335     


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
            340                 345                 350         


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
        355                 360                 365             


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
    370                 375                 380                 


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
385                 390                 395                 400 


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
                405                 410                 415     


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
            420                 425                 430         


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
        435                 440                 445             


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
    450                 455                 460                 


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
465                 470                 475                 480 


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
                485                 490                 495     


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
            500                 505                 510         


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
        515                 520                 525             


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
    530                 535                 540                 


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
545                 550                 555                 560 


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
                565                 570                 575     


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
            580                 585                 590         


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
        595                 600                 605             


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
    610                 615                 620                 


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
625                 630                 635                 640 


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
                645                 650                 655     


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
            660                 665                 670         


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
        675                 680                 685             


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
    690                 695                 700                 


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
705                 710                 715                 720 


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
                725                 730                 735     


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
            740                 745                 750         


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
        755                 760                 765             


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
    770                 775                 780                 


Leu Gly Leu 
785         


<210>  443
<211>  786
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  443

His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
1               5                   10                  15      


Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 
            20                  25                  30          


Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 
        35                  40                  45              


Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 
    50                  55                  60                  


Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 
65                  70                  75                  80  


Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 
                85                  90                  95      


Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 
            100                 105                 110         


Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro 
        115                 120                 125             


Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 
    130                 135                 140                 


Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser 
                165                 170                 175     


Pro Ser Tyr Ala Ser Gly Glu Thr Gly Ser Ser Gly Glu Gly Thr Gly 
            180                 185                 190         


Ser Thr Gly Ser Gly Ala Gly Glu Ser Asp Ala His Lys Ser Glu Val 
        195                 200                 205             


Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val 
    210                 215                 220                 


Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ala Pro Phe Glu Asp His 
225                 230                 235                 240 


Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala 
                245                 250                 255     


Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly 
            260                 265                 270         


Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met 
        275                 280                 285             


Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu 
    290                 295                 300                 


Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu 
305                 310                 315                 320 


Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu 
                325                 330                 335     


Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala 
            340                 345                 350         


Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu 
        355                 360                 365             


Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp 
    370                 375                 380                 


Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys 
385                 390                 395                 400 


Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala 
                405                 410                 415     


Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val 
            420                 425                 430         


Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His 
        435                 440                 445             


Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr 
    450                 455                 460                 


Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys 
465                 470                 475                 480 


Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn 
                485                 490                 495     


Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu 
            500                 505                 510         


Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu 
        515                 520                 525             


Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val 
    530                 535                 540                 


Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys 
545                 550                 555                 560 


Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp 
                565                 570                 575     


Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn 
            580                 585                 590         


Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu 
        595                 600                 605             


Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu 
    610                 615                 620                 


Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys 
625                 630                 635                 640 


His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val 
                645                 650                 655     


Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp 
            660                 665                 670         


Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys 
        675                 680                 685             


Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn 
    690                 695                 700                 


Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys 
705                 710                 715                 720 


Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His 
                725                 730                 735     


Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe 
            740                 745                 750         


Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys 
        755                 760                 765             


Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu 
    770                 775                 780                 


Gly Leu 
785     


<210> 444

<400> 444
000


<210> 445

<400> 445
000


<210>  446
<211>  964
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  446

His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
1               5                   10                  15      


Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 
            20                  25                  30          


Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 
        35                  40                  45              


Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 
    50                  55                  60                  


Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 
65                  70                  75                  80  


Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 
                85                  90                  95      


Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 
            100                 105                 110         


Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu 
        115                 120                 125             


Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu 
    130                 135                 140                 


Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val 
145                 150                 155                 160 


Glu Pro Ser Gln Glu Arg Ser Pro Ser Tyr Ala Ser Gly Glu Thr Gly 
                165                 170                 175     


Ser Ser Gly Glu Gly Thr Gly Ser Thr Gly Ser Gly Ala Gly Glu Ser 
            180                 185                 190         


Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
        195                 200                 205             


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
    210                 215                 220                 


Gln Ala Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
225                 230                 235                 240 


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
                245                 250                 255     


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
            260                 265                 270         


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
        275                 280                 285             


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
    290                 295                 300                 


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
305                 310                 315                 320 


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
                325                 330                 335     


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
            340                 345                 350         


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
        355                 360                 365             


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
    370                 375                 380                 


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
385                 390                 395                 400 


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
                405                 410                 415     


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
            420                 425                 430         


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
        435                 440                 445             


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
    450                 455                 460                 


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
465                 470                 475                 480 


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
                485                 490                 495     


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
            500                 505                 510         


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
        515                 520                 525             


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
    530                 535                 540                 


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
545                 550                 555                 560 


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
                565                 570                 575     


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
            580                 585                 590         


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
        595                 600                 605             


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
    610                 615                 620                 


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
625                 630                 635                 640 


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
                645                 650                 655     


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
            660                 665                 670         


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
        675                 680                 685             


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
    690                 695                 700                 


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
705                 710                 715                 720 


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
                725                 730                 735     


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
            740                 745                 750         


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
        755                 760                 765             


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly Ser Gly Gly 
    770                 775                 780                 


Gly Gly Ser Gly Gly Gly Gly Ser His Pro Ile Pro Asp Ser Ser Pro 
785                 790                 795                 800 


Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp 
                805                 810                 815     


Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr 
            820                 825                 830         


Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys 
        835                 840                 845             


Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg 
    850                 855                 860                 


Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe 
865                 870                 875                 880 


Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr 
                885                 890                 895     


Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Gly Ser 
            900                 905                 910         


Gly Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala 
        915                 920                 925             


Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly 
    930                 935                 940                 


Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Glu Arg Ser Pro 
945                 950                 955                 960 


Ser Tyr Ala Ser 
                


<210>  447
<211>  982
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  447

His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
1               5                   10                  15      


Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 
            20                  25                  30          


Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 
        35                  40                  45              


Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 
    50                  55                  60                  


Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 
65                  70                  75                  80  


Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 
                85                  90                  95      


Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 
            100                 105                 110         


Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro 
        115                 120                 125             


Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 
    130                 135                 140                 


Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser 
                165                 170                 175     


Pro Ser Tyr Ala Ser Gly Glu Thr Gly Ser Ser Gly Glu Gly Thr Gly 
            180                 185                 190         


Ser Thr Gly Ser Gly Ala Gly Glu Ser Asp Ala His Lys Ser Glu Val 
        195                 200                 205             


Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val 
    210                 215                 220                 


Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ala Pro Phe Glu Asp His 
225                 230                 235                 240 


Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala 
                245                 250                 255     


Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly 
            260                 265                 270         


Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met 
        275                 280                 285             


Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu 
    290                 295                 300                 


Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu 
305                 310                 315                 320 


Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu 
                325                 330                 335     


Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala 
            340                 345                 350         


Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu 
        355                 360                 365             


Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp 
    370                 375                 380                 


Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys 
385                 390                 395                 400 


Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala 
                405                 410                 415     


Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val 
            420                 425                 430         


Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His 
        435                 440                 445             


Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr 
    450                 455                 460                 


Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys 
465                 470                 475                 480 


Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn 
                485                 490                 495     


Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu 
            500                 505                 510         


Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu 
        515                 520                 525             


Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val 
    530                 535                 540                 


Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys 
545                 550                 555                 560 


Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp 
                565                 570                 575     


Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn 
            580                 585                 590         


Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu 
        595                 600                 605             


Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu 
    610                 615                 620                 


Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys 
625                 630                 635                 640 


His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val 
                645                 650                 655     


Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp 
            660                 665                 670         


Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys 
        675                 680                 685             


Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn 
    690                 695                 700                 


Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys 
705                 710                 715                 720 


Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His 
                725                 730                 735     


Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe 
            740                 745                 750         


Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys 
        755                 760                 765             


Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu 
    770                 775                 780                 


Gly Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
785                 790                 795                 800 


Ser His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
                805                 810                 815     


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
            820                 825                 830         


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
        835                 840                 845             


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
    850                 855                 860                 


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
865                 870                 875                 880 


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
                885                 890                 895     


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
            900                 905                 910         


His Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp 
        915                 920                 925             


Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro 
    930                 935                 940                 


Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp 
945                 950                 955                 960 


Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg 
                965                 970                 975     


Ser Pro Ser Tyr Ala Ser 
            980         


<210>  448
<211>  963
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  448

His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
1               5                   10                  15      


Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 
            20                  25                  30          


Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 
        35                  40                  45              


Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 
    50                  55                  60                  


Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 
65                  70                  75                  80  


Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 
                85                  90                  95      


Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 
            100                 105                 110         


Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu 
        115                 120                 125             


Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu 
    130                 135                 140                 


Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val 
145                 150                 155                 160 


Glu Pro Ser Gln Glu Arg Ser Pro Ser Tyr Ala Ser Gly Glu Thr Gly 
                165                 170                 175     


Ser Ser Gly Glu Gly Thr Gly Ser Thr Gly Ser Gly Ala Gly Glu Ser 
            180                 185                 190         


Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
        195                 200                 205             


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
    210                 215                 220                 


Gln Ala Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
225                 230                 235                 240 


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
                245                 250                 255     


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
            260                 265                 270         


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
        275                 280                 285             


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
    290                 295                 300                 


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
305                 310                 315                 320 


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
                325                 330                 335     


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
            340                 345                 350         


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
        355                 360                 365             


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
    370                 375                 380                 


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
385                 390                 395                 400 


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
                405                 410                 415     


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
            420                 425                 430         


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
        435                 440                 445             


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
    450                 455                 460                 


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
465                 470                 475                 480 


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
                485                 490                 495     


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
            500                 505                 510         


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
        515                 520                 525             


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
    530                 535                 540                 


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
545                 550                 555                 560 


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
                565                 570                 575     


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
            580                 585                 590         


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
        595                 600                 605             


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
    610                 615                 620                 


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
625                 630                 635                 640 


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
                645                 650                 655     


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
            660                 665                 670         


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
        675                 680                 685             


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
    690                 695                 700                 


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
705                 710                 715                 720 


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
                725                 730                 735     


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
            740                 745                 750         


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
        755                 760                 765             


Ala Ala Ser Gln Ala Ala Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly 
    770                 775                 780                 


Gly Ser Gly Gly Gly Gly Ser His Pro Ile Pro Asp Ser Ser Pro Leu 
785                 790                 795                 800 


Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp 
                805                 810                 815     


Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val 
            820                 825                 830         


Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala 
        835                 840                 845             


Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe 
    850                 855                 860                 


Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp 
865                 870                 875                 880 


Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn 
                885                 890                 895     


Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Gly Ser Gly 
            900                 905                 910         


Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro 
        915                 920                 925             


Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser 
    930                 935                 940                 


Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Glu Arg Ser Pro Ser 
945                 950                 955                 960 


Tyr Ala Ser 
            


<210>  449
<211>  981
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  449

His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
1               5                   10                  15      


Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 
            20                  25                  30          


Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 
        35                  40                  45              


Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 
    50                  55                  60                  


Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 
65                  70                  75                  80  


Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 
                85                  90                  95      


Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 
            100                 105                 110         


Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro 
        115                 120                 125             


Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 
    130                 135                 140                 


Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser 
                165                 170                 175     


Pro Ser Tyr Ala Ser Gly Glu Thr Gly Ser Ser Gly Glu Gly Thr Gly 
            180                 185                 190         


Ser Thr Gly Ser Gly Ala Gly Glu Ser Asp Ala His Lys Ser Glu Val 
        195                 200                 205             


Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val 
    210                 215                 220                 


Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ala Pro Phe Glu Asp His 
225                 230                 235                 240 


Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala 
                245                 250                 255     


Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly 
            260                 265                 270         


Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met 
        275                 280                 285             


Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu 
    290                 295                 300                 


Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu 
305                 310                 315                 320 


Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu 
                325                 330                 335     


Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala 
            340                 345                 350         


Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu 
        355                 360                 365             


Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp 
    370                 375                 380                 


Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys 
385                 390                 395                 400 


Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala 
                405                 410                 415     


Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val 
            420                 425                 430         


Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His 
        435                 440                 445             


Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr 
    450                 455                 460                 


Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys 
465                 470                 475                 480 


Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn 
                485                 490                 495     


Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu 
            500                 505                 510         


Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu 
        515                 520                 525             


Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val 
    530                 535                 540                 


Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys 
545                 550                 555                 560 


Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp 
                565                 570                 575     


Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn 
            580                 585                 590         


Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu 
        595                 600                 605             


Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu 
    610                 615                 620                 


Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys 
625                 630                 635                 640 


His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val 
                645                 650                 655     


Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp 
            660                 665                 670         


Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys 
        675                 680                 685             


Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn 
    690                 695                 700                 


Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys 
705                 710                 715                 720 


Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His 
                725                 730                 735     


Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe 
            740                 745                 750         


Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys 
        755                 760                 765             


Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu 
    770                 775                 780                 


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
785                 790                 795                 800 


His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
                805                 810                 815     


Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 
            820                 825                 830         


Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 
        835                 840                 845             


Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 
    850                 855                 860                 


Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 
865                 870                 875                 880 


Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 
                885                 890                 895     


Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 
            900                 905                 910         


Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro 
        915                 920                 925             


Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 
    930                 935                 940                 


Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 
945                 950                 955                 960 


Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser 
                965                 970                 975     


Pro Ser Tyr Ala Ser 
            980     


<210>  450
<211>  974
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  450

His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
1               5                   10                  15      


Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 
            20                  25                  30          


Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 
        35                  40                  45              


Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 
    50                  55                  60                  


Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 
65                  70                  75                  80  


Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 
                85                  90                  95      


Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 
            100                 105                 110         


Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu 
        115                 120                 125             


Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu 
    130                 135                 140                 


Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val 
145                 150                 155                 160 


Glu Pro Ser Gln Glu Arg Ser Pro Ser Tyr Ala Ser Gly Glu Thr Gly 
                165                 170                 175     


Ser Ser Gly Glu Gly Thr Gly Ser Thr Gly Ser Gly Ala Gly Glu Ser 
            180                 185                 190         


Gly Thr Gly Glu Ser Gly Glu Gly Gly Ser Asp Ala His Lys Ser Glu 
        195                 200                 205             


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
    210                 215                 220                 


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ala Pro Phe Glu Asp 
225                 230                 235                 240 


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
                245                 250                 255     


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
            260                 265                 270         


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
        275                 280                 285             


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
    290                 295                 300                 


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
305                 310                 315                 320 


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
                325                 330                 335     


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
            340                 345                 350         


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
        355                 360                 365             


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
    370                 375                 380                 


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
385                 390                 395                 400 


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
                405                 410                 415     


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
            420                 425                 430         


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
        435                 440                 445             


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
    450                 455                 460                 


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
465                 470                 475                 480 


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
                485                 490                 495     


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
            500                 505                 510         


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
        515                 520                 525             


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
    530                 535                 540                 


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
545                 550                 555                 560 


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
                565                 570                 575     


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
            580                 585                 590         


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
        595                 600                 605             


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
    610                 615                 620                 


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
625                 630                 635                 640 


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
                645                 650                 655     


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
            660                 665                 670         


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
        675                 680                 685             


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
    690                 695                 700                 


Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
705                 710                 715                 720 


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
                725                 730                 735     


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
            740                 745                 750         


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
        755                 760                 765             


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
    770                 775                 780                 


Leu Gly Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
785                 790                 795                 800 


Gly Ser His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly 
                805                 810                 815     


Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu 
            820                 825                 830         


Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp 
        835                 840                 845             


Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val 
    850                 855                 860                 


Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro 
865                 870                 875                 880 


Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser 
                885                 890                 895     


Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu 
            900                 905                 910         


Ala His Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg 
        915                 920                 925             


Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly 
    930                 935                 940                 


Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser 
945                 950                 955                 960 


Met Val Glu Pro Ser Gln Glu Arg Ser Pro Ser Tyr Ala Ser 
                965                 970                 


<210>  451
<211>  992
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  451

His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
1               5                   10                  15      


Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 
            20                  25                  30          


Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 
        35                  40                  45              


Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 
    50                  55                  60                  


Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 
65                  70                  75                  80  


Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 
                85                  90                  95      


Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 
            100                 105                 110         


Gly Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro 
        115                 120                 125             


Ala Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 
    130                 135                 140                 


Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser 
                165                 170                 175     


Pro Ser Tyr Ala Ser Gly Glu Thr Gly Ser Ser Gly Glu Gly Thr Gly 
            180                 185                 190         


Ser Thr Gly Ser Gly Ala Gly Glu Ser Gly Thr Gly Glu Ser Gly Glu 
        195                 200                 205             


Gly Gly Ser Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp 
    210                 215                 220                 


Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln 
225                 230                 235                 240 


Tyr Leu Gln Gln Ala Pro Phe Glu Asp His Val Lys Leu Val Asn Glu 
                245                 250                 255     


Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn 
            260                 265                 270         


Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val 
        275                 280                 285             


Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys 
    290                 295                 300                 


Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn 
305                 310                 315                 320 


Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr 
                325                 330                 335     


Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu 
            340                 345                 350         


Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe 
        355                 360                 365             


Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp 
    370                 375                 380                 


Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly 
385                 390                 395                 400 


Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys 
                405                 410                 415     


Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln 
            420                 425                 430         


Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp 
        435                 440                 445             


Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys 
    450                 455                 460                 


Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp 
465                 470                 475                 480 


Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu 
                485                 490                 495     


Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp 
            500                 505                 510         


Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys 
        515                 520                 525             


Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu 
    530                 535                 540                 


Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu 
545                 550                 555                 560 


Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp 
                565                 570                 575     


Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val 
            580                 585                 590         


Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln 
        595                 600                 605             


Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys 
    610                 615                 620                 


Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn 
625                 630                 635                 640 


Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg 
                645                 650                 655     


Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys 
            660                 665                 670         


Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys 
        675                 680                 685             


Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val 
    690                 695                 700                 


Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe 
705                 710                 715                 720 


His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys 
                725                 730                 735     


Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys 
            740                 745                 750         


Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys 
        755                 760                 765             


Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys 
    770                 775                 780                 


Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly 
785                 790                 795                 800 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Pro Ile Pro Asp 
                805                 810                 815     


Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu 
            820                 825                 830         


Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu 
        835                 840                 845             


Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu 
    850                 855                 860                 


Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys 
865                 870                 875                 880 


Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser 
                885                 890                 895     


Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu 
            900                 905                 910         


Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His 
        915                 920                 925             


Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro 
    930                 935                 940                 


Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro 
945                 950                 955                 960 


Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro 
                965                 970                 975     


Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
            980                 985                 990         


<210>  452
<211>  272
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  452

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp His Ser Tyr Tyr Glu Gln Asn Ser Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu 
        35                  40                  45              


Phe Thr Val Pro Tyr Ser Gln Thr Thr Ala Thr Ile Ser Gly Leu Lys 
    50                  55                  60                  


Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Tyr Gly Ser Lys 
65                  70                  75                  80  


Tyr Tyr Tyr Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Glu Lys Pro 
                85                  90                  95      


Ser Gln Gly Ser His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe 
            100                 105                 110         


Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln 
        115                 120                 125             


Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala 
    130                 135                 140                 


Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro 
145                 150                 155                 160 


Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln 
                165                 170                 175     


Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala 
            180                 185                 190         


Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln 
        195                 200                 205             


Ser Glu Ala His Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro 
    210                 215                 220                 


Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro 
225                 230                 235                 240 


Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro 
                245                 250                 255     


Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
            260                 265                 270         


<210>  453
<211>  275
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  453

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp His Ser Tyr Tyr Glu Gln Asn Ser Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu 
        35                  40                  45              


Phe Thr Val Pro Tyr Ser Gln Thr Thr Ala Thr Ile Ser Gly Leu Lys 
    50                  55                  60                  


Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Tyr Gly Ser Lys 
65                  70                  75                  80  


Tyr Tyr Tyr Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Glu Lys Pro 
                85                  90                  95      


Ser Gln Gly Gly Gly Gly Ser His Pro Ile Pro Asp Ser Ser Pro Leu 
            100                 105                 110         


Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp 
        115                 120                 125             


Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val 
    130                 135                 140                 


Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala 
145                 150                 155                 160 


Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe 
                165                 170                 175     


Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp 
            180                 185                 190         


Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn 
        195                 200                 205             


Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Gly Ser Gly 
    210                 215                 220                 


Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro 
225                 230                 235                 240 


Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser 
                245                 250                 255     


Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser 
            260                 265                 270         


Tyr Ala Ser 
        275 


<210>  454
<211>  280
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  454

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp His Ser Tyr Tyr Glu Gln Asn Ser Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu 
        35                  40                  45              


Phe Thr Val Pro Tyr Ser Gln Thr Thr Ala Thr Ile Ser Gly Leu Lys 
    50                  55                  60                  


Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Tyr Gly Ser Lys 
65                  70                  75                  80  


Tyr Tyr Tyr Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Glu Lys Pro 
                85                  90                  95      


Ser Gln Glu Glu Glu Glu Asp Glu Glu Glu Glu Asp His Pro Ile Pro 
            100                 105                 110         


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
        115                 120                 125             


Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 
    130                 135                 140                 


Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 
145                 150                 155                 160 


Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
                165                 170                 175     


Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 
            180                 185                 190         


Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 
        195                 200                 205             


Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 
    210                 215                 220                 


His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 
225                 230                 235                 240 


Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 
                245                 250                 255     


Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln 
            260                 265                 270         


Gly Arg Ser Pro Ser Tyr Ala Ser 
        275                 280 


<210>  455
<211>  280
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  455

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp His Ser Tyr Tyr Glu Gln Asn Ser Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu 
        35                  40                  45              


Phe Thr Val Pro Tyr Ser Gln Thr Thr Ala Thr Ile Ser Gly Leu Lys 
    50                  55                  60                  


Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Tyr Gly Ser Lys 
65                  70                  75                  80  


Tyr Tyr Tyr Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Glu Lys Pro 
                85                  90                  95      


Ser Gln Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro His Pro Ile Pro 
            100                 105                 110         


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
        115                 120                 125             


Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 
    130                 135                 140                 


Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 
145                 150                 155                 160 


Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
                165                 170                 175     


Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 
            180                 185                 190         


Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 
        195                 200                 205             


Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 
    210                 215                 220                 


His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 
225                 230                 235                 240 


Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 
                245                 250                 255     


Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln 
            260                 265                 270         


Gly Arg Ser Pro Ser Tyr Ala Ser 
        275                 280 


<210>  456
<211>  282
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  456

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp His Ser Tyr Tyr Glu Gln Asn Ser Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu 
        35                  40                  45              


Phe Thr Val Pro Tyr Ser Gln Thr Thr Ala Thr Ile Ser Gly Leu Lys 
    50                  55                  60                  


Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Tyr Gly Ser Lys 
65                  70                  75                  80  


Tyr Tyr Tyr Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Glu Lys Pro 
                85                  90                  95      


Ser Gln Gly Ser His His His His His His His His Gly Ser His Pro 
            100                 105                 110         


Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln 
        115                 120                 125             


Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu 
    130                 135                 140                 


Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu 
145                 150                 155                 160 


Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu 
                165                 170                 175     


Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu 
            180                 185                 190         


Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu 
        195                 200                 205             


Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu 
    210                 215                 220                 


Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu Pro Leu 
225                 230                 235                 240 


Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro 
                245                 250                 255     


Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro 
            260                 265                 270         


Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
        275                 280         


<210>  457
<211>  285
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  457

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp His Ser Tyr Tyr Glu Gln Asn Ser Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu 
        35                  40                  45              


Phe Thr Val Pro Tyr Ser Gln Thr Thr Ala Thr Ile Ser Gly Leu Lys 
    50                  55                  60                  


Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Tyr Gly Ser Lys 
65                  70                  75                  80  


Tyr Tyr Tyr Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Glu Lys Pro 
                85                  90                  95      


Ser Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            100                 105                 110         


Ser His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
        115                 120                 125             


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
    130                 135                 140                 


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
145                 150                 155                 160 


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
                165                 170                 175     


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
            180                 185                 190         


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
        195                 200                 205             


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
    210                 215                 220                 


His Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe 
225                 230                 235                 240 


Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile 
                245                 250                 255     


Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met 
            260                 265                 270         


Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
        275                 280                 285 


<210>  458
<211>  285
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  458

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp His Ser Tyr Tyr Glu Gln Asn Ser Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu 
        35                  40                  45              


Phe Thr Val Pro Tyr Ser Gln Thr Thr Ala Thr Ile Ser Gly Leu Lys 
    50                  55                  60                  


Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Tyr Gly Ser Lys 
65                  70                  75                  80  


Tyr Tyr Tyr Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Glu Lys Pro 
                85                  90                  95      


Ser Gln Gly Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly 
            100                 105                 110         


Ser His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
        115                 120                 125             


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
    130                 135                 140                 


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
145                 150                 155                 160 


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
                165                 170                 175     


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
            180                 185                 190         


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
        195                 200                 205             


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
    210                 215                 220                 


His Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe 
225                 230                 235                 240 


Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile 
                245                 250                 255     


Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met 
            260                 265                 270         


Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
        275                 280                 285 


<210>  459
<211>  286
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  459

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp His Ser Tyr Tyr Glu Gln Asn Ser Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu 
        35                  40                  45              


Phe Thr Val Pro Tyr Ser Gln Thr Thr Ala Thr Ile Ser Gly Leu Lys 
    50                  55                  60                  


Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Tyr Gly Ser Lys 
65                  70                  75                  80  


Tyr Tyr Tyr Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Glu Lys Pro 
                85                  90                  95      


Ser Gln Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
            100                 105                 110         


Gly Ser His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly 
        115                 120                 125             


Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu 
    130                 135                 140                 


Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp 
145                 150                 155                 160 


Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val 
                165                 170                 175     


Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro 
            180                 185                 190         


Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser 
        195                 200                 205             


Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu 
    210                 215                 220                 


Ala His Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg 
225                 230                 235                 240 


Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly 
                245                 250                 255     


Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser 
            260                 265                 270         


Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
        275                 280                 285     


<210>  460
<211>  288
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  460

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp His Ser Tyr Tyr Glu Gln Asn Ser Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu 
        35                  40                  45              


Phe Thr Val Pro Tyr Ser Gln Thr Thr Ala Thr Ile Ser Gly Leu Lys 
    50                  55                  60                  


Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Tyr Gly Ser Lys 
65                  70                  75                  80  


Tyr Tyr Tyr Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Glu Lys Pro 
                85                  90                  95      


Ser Gln Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr 
            100                 105                 110         


Pro Ser Pro Ser His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe 
        115                 120                 125             


Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln 
    130                 135                 140                 


Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala 
145                 150                 155                 160 


Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro 
                165                 170                 175     


Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln 
            180                 185                 190         


Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala 
        195                 200                 205             


Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln 
    210                 215                 220                 


Ser Glu Ala His Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro 
225                 230                 235                 240 


Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro 
                245                 250                 255     


Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro 
            260                 265                 270         


Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
        275                 280                 285             


<210>  461
<211>  293
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  461

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp His Ser Tyr Tyr Glu Gln Asn Ser Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu 
        35                  40                  45              


Phe Thr Val Pro Tyr Ser Gln Thr Thr Ala Thr Ile Ser Gly Leu Lys 
    50                  55                  60                  


Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Tyr Gly Ser Lys 
65                  70                  75                  80  


Tyr Tyr Tyr Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Glu Lys Pro 
                85                  90                  95      


Ser Gln Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu Glu 
            100                 105                 110         


Gln Glu Glu Arg Glu Thr Lys Thr Pro His Pro Ile Pro Asp Ser Ser 
        115                 120                 125             


Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr 
    130                 135                 140                 


Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly 
145                 150                 155                 160 


Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu 
                165                 170                 175     


Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser 
            180                 185                 190         


Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His 
        195                 200                 205             


Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly 
    210                 215                 220                 


Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Gly 
225                 230                 235                 240 


Ser Gly Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro 
                245                 250                 255     


Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val 
            260                 265                 270         


Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser 
        275                 280                 285             


Pro Ser Tyr Ala Ser 
    290             


<210>  462
<211>  295
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  462

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp His Ser Tyr Tyr Glu Gln Asn Ser Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu 
        35                  40                  45              


Phe Thr Val Pro Tyr Ser Gln Thr Thr Ala Thr Ile Ser Gly Leu Lys 
    50                  55                  60                  


Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Tyr Gly Ser Lys 
65                  70                  75                  80  


Tyr Tyr Tyr Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Glu Lys Pro 
                85                  90                  95      


Ser Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Pro Ile Pro Asp 
        115                 120                 125             


Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu 
    130                 135                 140                 


Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu 
145                 150                 155                 160 


Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu 
                165                 170                 175     


Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys 
            180                 185                 190         


Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser 
        195                 200                 205             


Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu 
    210                 215                 220                 


Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His 
225                 230                 235                 240 


Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu 
                245                 250                 255     


Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro 
            260                 265                 270         


Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly 
        275                 280                 285             


Arg Ser Pro Ser Tyr Ala Ser 
    290                 295 


<210>  463
<211>  300
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  463

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp His Ser Tyr Tyr Glu Gln Asn Ser Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu 
        35                  40                  45              


Phe Thr Val Pro Tyr Ser Gln Thr Thr Ala Thr Ile Ser Gly Leu Lys 
    50                  55                  60                  


Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Tyr Gly Ser Lys 
65                  70                  75                  80  


Tyr Tyr Tyr Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Glu Lys Pro 
                85                  90                  95      


Ser Gln Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro Pro Ser Pro Glu 
            100                 105                 110         


Pro Pro Thr Pro Glu Pro Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro 
        115                 120                 125             


His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
    130                 135                 140                 


Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 
145                 150                 155                 160 


Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 
                165                 170                 175     


Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 
            180                 185                 190         


Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 
        195                 200                 205             


Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 
    210                 215                 220                 


Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 
225                 230                 235                 240 


Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu 
                245                 250                 255     


Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu 
            260                 265                 270         


Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val 
        275                 280                 285             


Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
    290                 295                 300 


<210>  464
<211>  306
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  464

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp His Ser Tyr Tyr Glu Gln Asn Ser Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu 
        35                  40                  45              


Phe Thr Val Pro Tyr Ser Gln Thr Thr Ala Thr Ile Ser Gly Leu Lys 
    50                  55                  60                  


Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Tyr Gly Ser Lys 
65                  70                  75                  80  


Tyr Tyr Tyr Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Glu Lys Pro 
                85                  90                  95      


Ser Gln Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr 
            100                 105                 110         


Pro Ser Pro Ser Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro 
        115                 120                 125             


Pro Thr Pro Ser Pro Ser His Pro Ile Pro Asp Ser Ser Pro Leu Leu 
    130                 135                 140                 


Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala 
145                 150                 155                 160 


Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly 
                165                 170                 175     


Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu 
            180                 185                 190         


Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu 
        195                 200                 205             


Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro 
    210                 215                 220                 


Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val 
225                 230                 235                 240 


Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Gly Ser Gly Arg 
                245                 250                 255     


Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro 
            260                 265                 270         


Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser 
        275                 280                 285             


Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr 
    290                 295                 300                 


Ala Ser 
305     


<210>  465
<211>  275
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  465

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp His Ser Tyr Tyr Glu Gln Asn Ser Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu 
        35                  40                  45              


Phe Thr Val Pro Tyr Ser Gln Thr Thr Ala Thr Ile Ser Gly Leu Lys 
    50                  55                  60                  


Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Tyr Gly Ser Lys 
65                  70                  75                  80  


Tyr Tyr Tyr Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Glu Lys Pro 
                85                  90                  95      


Ser Gln Pro Ser Pro Glu Pro His Pro Ile Pro Asp Ser Ser Pro Leu 
            100                 105                 110         


Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp 
        115                 120                 125             


Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val 
    130                 135                 140                 


Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala 
145                 150                 155                 160 


Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe 
                165                 170                 175     


Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp 
            180                 185                 190         


Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn 
        195                 200                 205             


Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Gly Ser Gly 
    210                 215                 220                 


Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro 
225                 230                 235                 240 


Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser 
                245                 250                 255     


Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser 
            260                 265                 270         


Tyr Ala Ser 
        275 


<210>  466
<211>  290
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  466

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp His Ser Tyr Tyr Glu Gln Asn Ser Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu 
        35                  40                  45              


Phe Thr Val Pro Tyr Ser Gln Thr Thr Ala Thr Ile Ser Gly Leu Lys 
    50                  55                  60                  


Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Tyr Gly Ser Lys 
65                  70                  75                  80  


Tyr Tyr Tyr Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Glu Lys Pro 
                85                  90                  95      


Ser Gln Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro Pro Ser Pro Glu 
            100                 105                 110         


Pro Pro Thr Pro Glu Pro His Pro Ile Pro Asp Ser Ser Pro Leu Leu 
        115                 120                 125             


Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala 
    130                 135                 140                 


Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly 
145                 150                 155                 160 


Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu 
                165                 170                 175     


Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu 
            180                 185                 190         


Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro 
        195                 200                 205             


Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val 
    210                 215                 220                 


Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Gly Ser Gly Arg 
225                 230                 235                 240 


Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro 
                245                 250                 255     


Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser 
            260                 265                 270         


Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr 
        275                 280                 285             


Ala Ser 
    290 


<210>  467
<211>  310
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  467

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp His Ser Tyr Tyr Glu Gln Asn Ser Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu 
        35                  40                  45              


Phe Thr Val Pro Tyr Ser Gln Thr Thr Ala Thr Ile Ser Gly Leu Lys 
    50                  55                  60                  


Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Tyr Gly Ser Lys 
65                  70                  75                  80  


Tyr Tyr Tyr Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Glu Lys Pro 
                85                  90                  95      


Ser Gln Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro Pro Ser Pro Glu 
            100                 105                 110         


Pro Pro Thr Pro Glu Pro Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro 
        115                 120                 125             


Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro His Pro Ile Pro Asp Ser 
    130                 135                 140                 


Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr 
145                 150                 155                 160 


Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp 
                165                 170                 175     


Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln 
            180                 185                 190         


Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr 
        195                 200                 205             


Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu 
    210                 215                 220                 


His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp 
225                 230                 235                 240 


Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu 
                245                 250                 255     


Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro 
            260                 265                 270         


Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp 
        275                 280                 285             


Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg 
    290                 295                 300                 


Ser Pro Ser Tyr Ala Ser 
305                 310 


<210>  468
<211>  290
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  468

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp His Ser Tyr Tyr Glu Gln Asn Ser Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu 
        35                  40                  45              


Phe Thr Val Pro Tyr Ser Gln Thr Thr Ala Thr Ile Ser Gly Leu Lys 
    50                  55                  60                  


Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Tyr Gly Ser Lys 
65                  70                  75                  80  


Tyr Tyr Tyr Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Glu Lys Pro 
                85                  90                  95      


Ser Gln Pro Thr Pro Glu Pro Pro Ser Pro Glu Pro Pro Thr Pro Glu 
            100                 105                 110         


Pro Pro Ser Pro Glu Pro His Pro Ile Pro Asp Ser Ser Pro Leu Leu 
        115                 120                 125             


Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala 
    130                 135                 140                 


Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly 
145                 150                 155                 160 


Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu 
                165                 170                 175     


Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu 
            180                 185                 190         


Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro 
        195                 200                 205             


Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val 
    210                 215                 220                 


Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Gly Ser Gly Arg 
225                 230                 235                 240 


Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro 
                245                 250                 255     


Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser 
            260                 265                 270         


Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr 
        275                 280                 285             


Ala Ser 
    290 


<210>  469
<211>  284
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  469

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp His Ser Tyr Tyr Glu Gln Asn Ser Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu 
        35                  40                  45              


Phe Thr Val Pro Tyr Ser Gln Thr Thr Ala Thr Ile Ser Gly Leu Lys 
    50                  55                  60                  


Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Tyr Gly Ser Lys 
65                  70                  75                  80  


Tyr Tyr Tyr Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Glu Lys Pro 
                85                  90                  95      


Ser Gln Pro Ser Pro Glu Pro Gly Gly Gly Ser Pro Thr Pro Glu Pro 
            100                 105                 110         


His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
        115                 120                 125             


Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 
    130                 135                 140                 


Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 
145                 150                 155                 160 


Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 
                165                 170                 175     


Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 
            180                 185                 190         


Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 
        195                 200                 205             


Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 
    210                 215                 220                 


Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu 
225                 230                 235                 240 


Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu 
                245                 250                 255     


Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val 
            260                 265                 270         


Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
        275                 280                 


<210>  470
<211>  284
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  470

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp His Ser Tyr Tyr Glu Gln Asn Ser Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu 
        35                  40                  45              


Phe Thr Val Pro Tyr Ser Gln Thr Thr Ala Thr Ile Ser Gly Leu Lys 
    50                  55                  60                  


Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Tyr Gly Ser Lys 
65                  70                  75                  80  


Tyr Tyr Tyr Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Glu Lys Pro 
                85                  90                  95      


Ser Gln Pro Ser Pro Glu Pro Glu Glu Glu Asp Pro Thr Pro Glu Pro 
            100                 105                 110         


His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
        115                 120                 125             


Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 
    130                 135                 140                 


Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 
145                 150                 155                 160 


Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 
                165                 170                 175     


Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 
            180                 185                 190         


Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 
        195                 200                 205             


Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 
    210                 215                 220                 


Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu 
225                 230                 235                 240 


Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu 
                245                 250                 255     


Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val 
            260                 265                 270         


Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
        275                 280                 


<210>  471
<211>  294
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  471

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp His Ser Tyr Tyr Glu Gln Asn Ser Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu 
        35                  40                  45              


Phe Thr Val Pro Tyr Ser Gln Thr Thr Ala Thr Ile Ser Gly Leu Lys 
    50                  55                  60                  


Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Tyr Gly Ser Lys 
65                  70                  75                  80  


Tyr Tyr Tyr Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Glu Lys Pro 
                85                  90                  95      


Ser Gln Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro Glu Glu Glu Asp 
            100                 105                 110         


Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro His Pro Ile Pro Asp Ser 
        115                 120                 125             


Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr 
    130                 135                 140                 


Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp 
145                 150                 155                 160 


Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln 
                165                 170                 175     


Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr 
            180                 185                 190         


Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu 
        195                 200                 205             


His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp 
    210                 215                 220                 


Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu 
225                 230                 235                 240 


Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro 
                245                 250                 255     


Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp 
            260                 265                 270         


Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg 
        275                 280                 285             


Ser Pro Ser Tyr Ala Ser 
    290                 


<210>  472
<211>  304
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  472

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp His Ser Tyr Tyr Glu Gln Asn Ser Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu 
        35                  40                  45              


Phe Thr Val Pro Tyr Ser Gln Thr Thr Ala Thr Ile Ser Gly Leu Lys 
    50                  55                  60                  


Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Tyr Gly Ser Lys 
65                  70                  75                  80  


Tyr Tyr Tyr Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Glu Lys Pro 
                85                  90                  95      


Ser Gln Pro Thr Pro Glu Pro Pro Ser Pro Glu Pro Pro Thr Pro Glu 
            100                 105                 110         


Pro Glu Glu Glu Asp Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro Pro 
        115                 120                 125             


Ser Pro Glu Pro His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe 
    130                 135                 140                 


Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln 
145                 150                 155                 160 


Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala 
                165                 170                 175     


Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro 
            180                 185                 190         


Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln 
        195                 200                 205             


Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala 
    210                 215                 220                 


Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln 
225                 230                 235                 240 


Ser Glu Ala His Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro 
                245                 250                 255     


Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro 
            260                 265                 270         


Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro 
        275                 280                 285             


Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
    290                 295                 300                 


<210>  473
<211>  305
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  473

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp His Ser Tyr Tyr Glu Gln Asn Ser Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu 
        35                  40                  45              


Phe Thr Val Pro Tyr Ser Gln Thr Thr Ala Thr Ile Ser Gly Leu Lys 
    50                  55                  60                  


Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Tyr Gly Ser Lys 
65                  70                  75                  80  


Tyr Tyr Tyr Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Glu Lys Pro 
                85                  90                  95      


Ser Gln Pro Thr Pro Glu Pro Pro Ser Pro Glu Pro Pro Thr Pro Glu 
            100                 105                 110         


Pro Gly Gly Gly Gly Ser Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro 
        115                 120                 125             


Pro Ser Pro Glu Pro His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln 
    130                 135                 140                 


Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln 
145                 150                 155                 160 


Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly 
                165                 170                 175     


Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys 
            180                 185                 190         


Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys 
        195                 200                 205             


Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu 
    210                 215                 220                 


Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr 
225                 230                 235                 240 


Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly 
                245                 250                 255     


Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu 
            260                 265                 270         


Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp 
        275                 280                 285             


Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
    290                 295                 300                 


Ser 
305 


<210>  474
<211>  296
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  474

Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp His Ser Tyr Tyr Glu Gln Asn Ser Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu 
        35                  40                  45              


Phe Thr Val Pro Tyr Ser Gln Thr Thr Ala Thr Ile Ser Gly Leu Lys 
    50                  55                  60                  


Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Tyr Gly Ser Lys 
65                  70                  75                  80  


Tyr Tyr Tyr Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Glu Lys Pro 
                85                  90                  95      


Ser Gln Pro Ser Pro Glu Pro Thr Pro Glu Pro Ser Pro Glu Pro Pro 
            100                 105                 110         


Thr Pro Glu Pro Ser Pro Glu Pro Thr Pro Glu Pro His Pro Ile Pro 
        115                 120                 125             


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
    130                 135                 140                 


Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 
145                 150                 155                 160 


Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 
                165                 170                 175     


Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
            180                 185                 190         


Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 
        195                 200                 205             


Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 
    210                 215                 220                 


Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 
225                 230                 235                 240 


His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly 
                245                 250                 255     


Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro 
            260                 265                 270         


Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln 
        275                 280                 285             


Gly Arg Ser Pro Ser Tyr Ala Ser 
    290                 295     


<210>  475
<211>  414
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  475

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly 
                245                 250                 255     


Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu 
            260                 265                 270         


Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp 
        275                 280                 285             


Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val 
    290                 295                 300                 


Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro 
305                 310                 315                 320 


Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser 
                325                 330                 335     


Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu 
            340                 345                 350         


Ala His Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg 
        355                 360                 365             


Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly 
    370                 375                 380                 


Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser 
385                 390                 395                 400 


Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
                405                 410                 


<210>  476
<211>  427
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  476

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser His 
                245                 250                 255     


Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg 
            260                 265                 270         


Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu 
        275                 280                 285             


Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro 
    290                 295                 300                 


Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile 
305                 310                 315                 320 


Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala 
                325                 330                 335     


Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu 
            340                 345                 350         


Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly 
        355                 360                 365             


Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu Pro 
    370                 375                 380                 


Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala 
385                 390                 395                 400 


Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu 
                405                 410                 415     


Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
            420                 425         


<210>  477
<211>  429
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  477

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro Pro Ser Pro 
225                 230                 235                 240 


Glu Pro Pro Thr Pro Glu Pro Pro Ser Pro Glu Pro Pro Thr Pro Glu 
                245                 250                 255     


Pro His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln 
            260                 265                 270         


Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala 
        275                 280                 285             


His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln 
    290                 295                 300                 


Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile 
305                 310                 315                 320 


Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp 
                325                 330                 335     


Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe 
            340                 345                 350         


Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala 
        355                 360                 365             


His Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe 
    370                 375                 380                 


Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile 
385                 390                 395                 400 


Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met 
                405                 410                 415     


Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
            420                 425                 


<210>  478
<211>  414
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  478

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Pro Ser Pro Glu Pro Pro Thr Pro Glu Pro Pro Ser Pro 
225                 230                 235                 240 


Glu Pro His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly 
                245                 250                 255     


Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu 
            260                 265                 270         


Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp 
        275                 280                 285             


Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val 
    290                 295                 300                 


Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro 
305                 310                 315                 320 


Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser 
                325                 330                 335     


Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu 
            340                 345                 350         


Ala His Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg 
        355                 360                 365             


Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly 
    370                 375                 380                 


Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser 
385                 390                 395                 400 


Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
                405                 410                 


<210>  479
<211>  411
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  479

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Ser His His His His His His His His Gly Ser His 
225                 230                 235                 240 


Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg 
                245                 250                 255     


Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu 
            260                 265                 270         


Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro 
        275                 280                 285             


Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile 
    290                 295                 300                 


Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala 
305                 310                 315                 320 


Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu 
                325                 330                 335     


Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly 
            340                 345                 350         


Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu Pro 
        355                 360                 365             


Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu Ala 
    370                 375                 380                 


Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Glu 
385                 390                 395                 400 


Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
                405                 410     


<210>  480
<211>  416
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  480

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Glu Leu Gln Leu Glu Glu Ser Ala Ala Glu Ala Gln Glu 
225                 230                 235                 240 


Gly Glu Leu Glu His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe 
                245                 250                 255     


Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln 
            260                 265                 270         


Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala 
        275                 280                 285             


Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro 
    290                 295                 300                 


Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln 
305                 310                 315                 320 


Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala 
                325                 330                 335     


Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln 
            340                 345                 350         


Ser Glu Ala His Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro 
        355                 360                 365             


Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro 
    370                 375                 380                 


Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro 
385                 390                 395                 400 


Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
                405                 410                 415     


<210>  481
<211>  415
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  481

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Gly Ser His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly 
                245                 250                 255     


Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr 
            260                 265                 270         


Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala 
        275                 280                 285             


Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly 
    290                 295                 300                 


Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg 
305                 310                 315                 320 


Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys 
                325                 330                 335     


Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser 
            340                 345                 350         


Glu Ala His Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala 
        355                 360                 365             


Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro 
    370                 375                 380                 


Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu 
385                 390                 395                 400 


Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
                405                 410                 415 


<210>  482
<211>  414
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  482

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly 
                245                 250                 255     


Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu 
            260                 265                 270         


Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp 
        275                 280                 285             


Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val 
    290                 295                 300                 


Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro 
305                 310                 315                 320 


Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser 
                325                 330                 335     


Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu 
            340                 345                 350         


Ala His Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg 
        355                 360                 365             


Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly 
    370                 375                 380                 


Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser 
385                 390                 395                 400 


Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
                405                 410                 


<210>  483
<211>  412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  483

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
225                 230                 235                 240 


His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val 
                245                 250                 255     


Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His 
            260                 265                 270         


Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser 
        275                 280                 285             


Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln 
    290                 295                 300                 


Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly 
305                 310                 315                 320 


Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg 
                325                 330                 335     


Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His 
            340                 345                 350         


Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg Phe Leu 
        355                 360                 365             


Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly Ile Leu 
    370                 375                 380                 


Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val 
385                 390                 395                 400 


Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
                405                 410         


<210>  484
<211>  413
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  484

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly 
                245                 250                 255     


Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu 
            260                 265                 270         


Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp 
        275                 280                 285             


Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val 
    290                 295                 300                 


Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro 
305                 310                 315                 320 


Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser 
                325                 330                 335     


Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu 
            340                 345                 350         


Ala His Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg 
        355                 360                 365             


Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly 
    370                 375                 380                 


Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser 
385                 390                 395                 400 


Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
                405                 410             


<210>  485
<211>  411
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  485

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly 
                245                 250                 255     


Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu 
            260                 265                 270         


Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp 
        275                 280                 285             


Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val 
    290                 295                 300                 


Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro 
305                 310                 315                 320 


Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser 
                325                 330                 335     


Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu 
            340                 345                 350         


Ala His Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg 
        355                 360                 365             


Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly 
    370                 375                 380                 


Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser 
385                 390                 395                 400 


Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser 
                405                 410     


<210>  486
<211>  419
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  486

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser His Pro Ile Pro Asp Ser Ser Pro Leu 
                245                 250                 255     


Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp 
            260                 265                 270         


Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val 
        275                 280                 285             


Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala 
    290                 295                 300                 


Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe 
305                 310                 315                 320 


Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp 
                325                 330                 335     


Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn 
            340                 345                 350         


Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Gly Ser Gly 
        355                 360                 365             


Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro 
    370                 375                 380                 


Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser 
385                 390                 395                 400 


Ser Asp Pro Leu Ser Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser 
                405                 410                 415     


Tyr Ala Ser 
            


<210>  487
<211>  414
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic sequence

<400>  487

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser His Pro Ile Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly 
                245                 250                 255     


Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu 
            260                 265                 270         


Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp 
        275                 280                 285             


Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val 
    290                 295                 300                 


Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro 
305                 310                 315                 320 


Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser 
                325                 330                 335     


Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu 
            340                 345                 350         


Ala His Gly Leu Pro Leu His Leu Gly Ser Gly Arg Gly Pro Ala Arg 
        355                 360                 365             


Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Pro Pro Glu Pro Pro Gly 
    370                 375                 380                 


Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser 
385                 390                 395                 400 


Met Val Glu Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
                405                 410                 


