                               SEQUENCE LISTING

<110> EXTEND BIOSCIENCES, INC.
 
<120> THERAPEUTIC VITAMIN D CONJUGATES

<130> XTND005W

<140> PCT/US2015/056723
<141> 2015-10-21

<150> 62/244,181
<151> 2015-10-20

<150> 62/067,388
<151> 2014-10-22

<160> 23    

<170> PatentIn version 3.5

<210> 1
<211> 13
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Apelin peptide

<400> 1
Gln Arg Pro Arg Leu Ser His Lys Gly Pro Met Pro Phe 
1               5                   10              


<210> 2
<211> 28
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Octanoylated-Ser

<400> 2
Gly Ser Ser Phe Leu Ser Pro Glu His Gln Arg Val Gln Gln Arg Lys 
1               5                   10                  15      


Glu Ser Lys Lys Pro Pro Ala Lys Leu Gln Pro Arg 
            20                  25              


<210> 3
<211> 29
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Octanoylated-Ser

<400> 3
Gly Ser Ser Phe Leu Ser Pro Glu His Gln Arg Val Gln Gln Arg Lys 
1               5                   10                  15      


Glu Ser Lys Lys Pro Pro Ala Lys Leu Gln Pro Arg Cys 
            20                  25                  


<210> 4
<211> 30
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Octanoylated-Dap

<400> 4
Gly Ser Ser Xaa Phe Leu Ser Pro Glu His Gln Arg Val Gln Gln Arg 
1               5                   10                  15      


Lys Glu Ser Lys Lys Pro Pro Ala Lys Leu Gln Pro Arg Cys 
            20                  25                  30  


<210> 5
<211> 29
<212> PRT
<213> Homo sapiens

<400> 5
Gly Ser Tyr Phe Leu Ser Pro Glu His Gln Arg Val Gln Gln Arg Lys 
1               5                   10                  15      


Glu Ser Lys Lys Pro Pro Ala Lys Leu Gln Pro Arg Cys 
            20                  25                  


<210> 6
<211> 28
<212> PRT
<213> Rattus norvegicus


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Octanoylated-Ser

<400> 6
Gly Ser Ser Phe Leu Ser Pro Glu His Gln Lys Ala Gln Gln Pro Lys 
1               5                   10                  15      


Glu Ser Lys Lys Pro Pro Ala Lys Leu Gln Pro Arg 
            20                  25              


<210> 7
<211> 29
<212> PRT
<213> Rattus norvegicus


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Octanoylated-Ser

<400> 7
Gly Ser Ser Phe Leu Ser Pro Glu His Gln Lys Ala Gln Gln Pro Lys 
1               5                   10                  15      


Glu Ser Lys Lys Pro Pro Ala Lys Leu Gln Pro Arg Cys 
            20                  25                  


<210> 8
<211> 29
<212> PRT
<213> Rattus norvegicus


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Octanoylated-Dap

<400> 8
Gly Ser Xaa Phe Leu Ser Pro Glu His Gln Lys Ala Gln Gln Pro Lys 
1               5                   10                  15      


Glu Ser Lys Lys Pro Pro Ala Lys Leu Gln Pro Arg Cys 
            20                  25                  


<210> 9
<211> 29
<212> PRT
<213> Rattus norvegicus

<400> 9
Gly Ser Trp Phe Leu Ser Pro Glu His Gln Lys Ala Gln Gln Pro Lys 
1               5                   10                  15      


Glu Ser Lys Lys Pro Pro Ala Lys Leu Gln Pro Arg Cys 
            20                  25                  


<210> 10
<211> 34
<212> PRT
<213> Homo sapiens

<400> 10
Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210> 11
<211> 21
<212> PRT
<213> Homo sapiens

<400> 11
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210> 12
<211> 30
<212> PRT
<213> Homo sapiens

<400> 12
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210> 13
<211> 233
<212> PRT
<213> Homo sapiens

<400> 13
Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Phe Ser Phe Ile Ser Pro Phe Ala Gln Ala Val Arg Ser Ser 
65                  70                  75                  80  


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
                85                  90                  95      


Gln Ala Glu Gly Gln Phe Gln Trp Phe Asn Arg Arg Ala Asn Ala Phe 
            100                 105                 110         


Phe Ala Asn Gly Val Glu Phe Arg Asp Asn Gln Phe Val Val Pro Ser 
        115                 120                 125             


Glu Gly Phe Tyr Phe Ile Tyr Ser Gln Val Phe Phe Lys Gly Gln Gly 
    130                 135                 140                 


Cys Pro Ser Thr His Val Phe Phe Thr His Thr Ile Ser Arg Ile Ala 
145                 150                 155                 160 


Val Ser Tyr Gln Thr Lys Val Asn Phe Phe Ser Ala Ile Lys Ser Pro 
                165                 170                 175     


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            180                 185                 190         


Pro Ile Tyr Phe Gly Gly Val Phe Gln Phe Glu Lys Gly Asp Arg Phe 
        195                 200                 205             


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Phe Asp Phe Ala Glu Ser Gly 
    210                 215                 220                 


Gln Val Tyr Phe Gly Ile Ile Ala Phe 
225                 230             


<210> 14
<211> 474
<212> PRT
<213> Homo sapiens

<400> 14
Met Lys Arg Val Leu Val Leu Leu Leu Ala Val Ala Phe Gly His Ala 
1               5                   10                  15      


Leu Glu Arg Gly Arg Asp Tyr Glu Lys Asn Lys Val Cys Lys Glu Phe 
            20                  25                  30          


Ser His Leu Gly Lys Glu Asp Phe Thr Ser Leu Ser Leu Val Leu Tyr 
        35                  40                  45              


Ser Arg Lys Phe Pro Ser Gly Thr Phe Glu Gln Val Ser Gln Phe Val 
    50                  55                  60                  


Lys Glu Val Val Ser Phe Thr Glu Ala Cys Cys Ala Glu Gly Ala Asp 
65                  70                  75                  80  


Pro Asp Cys Tyr Asp Thr Arg Thr Ser Ala Phe Ser Ala Lys Ser Cys 
                85                  90                  95      


Glu Ser Asn Ser Pro Phe Pro Val His Pro Gly Thr Ala Glu Cys Cys 
            100                 105                 110         


Thr Lys Glu Gly Phe Glu Arg Lys Leu Cys Met Ala Ala Leu Lys His 
        115                 120                 125             


Gln Pro Gln Glu Phe Pro Thr Tyr Val Glu Pro Thr Asn Asp Glu Ile 
    130                 135                 140                 


Cys Glu Ala Phe Arg Lys Asp Pro Lys Glu Tyr Ala Asn Gln Phe Met 
145                 150                 155                 160 


Trp Glu Tyr Ser Thr Asn Tyr Gly Gln Ala Pro Leu Ser Leu Leu Val 
                165                 170                 175     


Ser Tyr Thr Lys Ser Tyr Leu Ser Met Val Gly Ser Cys Cys Thr Ser 
            180                 185                 190         


Ala Ser Pro Thr Val Cys Phe Leu Lys Glu Arg Leu Gln Leu Lys His 
        195                 200                 205             


Leu Ser Leu Leu Thr Thr Leu Ser Asn Arg Val Cys Ser Gln Tyr Ala 
    210                 215                 220                 


Ala Tyr Gly Glu Lys Lys Ser Arg Leu Ser Asn Leu Ile Lys Leu Ala 
225                 230                 235                 240 


Gln Lys Val Pro Thr Ala Asp Leu Glu Asp Val Leu Pro Leu Ala Glu 
                245                 250                 255     


Asp Ile Thr Asn Ile Leu Ser Lys Cys Cys Glu Ser Ala Ser Glu Asp 
            260                 265                 270         


Cys Met Ala Lys Glu Leu Pro Glu His Thr Val Lys Leu Cys Asp Asn 
        275                 280                 285             


Leu Ser Thr Lys Asn Ser Lys Phe Glu Asp Cys Cys Gln Glu Lys Thr 
    290                 295                 300                 


Ala Met Asp Val Phe Val Cys Thr Tyr Phe Met Pro Ala Ala Gln Leu 
305                 310                 315                 320 


Pro Glu Leu Pro Asp Val Glu Leu Pro Thr Asn Lys Asp Val Cys Asp 
                325                 330                 335     


Pro Gly Asn Thr Lys Val Met Asp Lys Tyr Thr Phe Glu Leu Ser Arg 
            340                 345                 350         


Arg Thr His Leu Pro Glu Val Phe Leu Ser Lys Val Leu Glu Pro Thr 
        355                 360                 365             


Leu Lys Ser Leu Gly Glu Cys Cys Asp Val Glu Asp Ser Thr Thr Cys 
    370                 375                 380                 


Phe Asn Ala Lys Gly Pro Leu Leu Lys Lys Glu Leu Ser Ser Phe Ile 
385                 390                 395                 400 


Asp Lys Gly Gln Glu Leu Cys Ala Asp Tyr Ser Glu Asn Thr Phe Thr 
                405                 410                 415     


Glu Tyr Lys Lys Lys Leu Ala Glu Arg Leu Lys Ala Lys Leu Pro Asp 
            420                 425                 430         


Ala Thr Pro Thr Glu Leu Ala Lys Leu Val Asn Lys His Ser Asp Phe 
        435                 440                 445             


Ala Ser Asn Cys Cys Ser Ile Asn Ser Pro Pro Leu Tyr Cys Asp Ser 
    450                 455                 460                 


Glu Ile Asp Ala Glu Leu Lys Asn Ile Leu 
465                 470                 


<210> 15
<211> 1801
<212> DNA
<213> Homo sapiens

<400> 15
tttaataata attctgtgtt gcttctgaga ttaataattg attaattcat agtcaggaat       60

ctttgtaaaa aggaaaccaa ttacttttgg ctaccacttt tacatggtca cctacaggag      120

agaggaggtg ctgcaagact ctctggtaga aaaatgaaga gggtcctggt actactgctt      180

gctgtggcat ttggacatgc tttagagaga ggccgggatt atgaaaagaa taaagtctgc      240

aaggaattct cccatctggg aaaggaggac ttcacatctc tgtcactagt cctgtacagt      300

agaaaatttc ccagtggcac gtttgaacag gtcagccaac ttgtgaagga agttgtctcc      360

ttgaccgaag cctgctgtgc ggaaggggct gaccctgact gctatgacac caggacctca      420

gcactgtctg ccaagtcctg tgaaagtaat tctccattcc ccgttcaccc aggcactgct      480

gagtgctgca ccaaagaggg cctggaacga aagctctgca tggctgctct gaaacaccag      540

ccacaggaat tccctaccta cgtggaaccc acaaatgatg aaatctgtga ggcgttcagg      600

aaagatccaa aggaatatgc taatcaattt atgtgggaat attccactaa ttacggacaa      660

gctcctctgt cacttttagt cagttacacc aagagttatc tttctatggt agggtcctgc      720

tgtacctctg caagcccaac tgtatgcttt ttgaaagaga gactccagct taaacattta      780

tcacttctca ccactctgtc aaatagagtc tgctcacaat atgctgctta tggggagaag      840

aaatcaaggc tcagcaatct cataaagtta gcccaaaaag tgcctactgc tgatctggag      900

gatgttttgc cactagctga agatattact aacatcctct ccaaatgctg tgagtctgcc      960

tctgaagatt gcatggccaa agagctgcct gaacacacag taaaactctg tgacaattta     1020

tccacaaaga attctaagtt tgaagactgt tgtcaagaaa aaacagccat ggacgttttt     1080

gtgtgcactt acttcatgcc agctgcccaa ctccccgagc ttccagatgt agagttgccc     1140

acaaacaaag atgtgtgtga tccaggaaac accaaagtca tggataagta tacatttgaa     1200

ctaagcagaa ggactcatct tccggaagta ttcctcagta aggtacttga gccaacccta     1260

aaaagccttg gtgaatgctg tgatgttgaa gactcaacta cctgttttaa tgctaagggc     1320

cctctactaa agaaggaact atcttctttc attgacaagg gacaagaact atgtgcagat     1380

tattcagaaa atacatttac tgagtacaag aaaaaactgg cagagcgact aaaagcaaaa     1440

ttgcctgatg ccacacccac ggaactggca aagctggtta acaagcactc agactttgcc     1500

tccaactgct gttccataaa ctcacctcct ctttactgtg attcagagat tgatgctgaa     1560

ttgaagaata tcctgtagtc ctgaagcatg tttattaact ttgaccagag ttggagccac     1620

ccaggggaat gatctctgat gacctaacct aagcaaaacc actgagcttc tgggaagaca     1680

actaggatac tttctacttt ttctagctac aatatcttca tacaatgaca agtatgatga     1740

tttgctatca aaataaattg aaatataatg caaaccataa aaaaaaaaaa aaaaaaaaaa     1800

a                                                                     1801


<210> 16
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Cys Gln Arg Pro Arg Leu Ser His Lys Gly Pro Met Pro Phe 
1               5                   10                  


<210> 17
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Cys 
        35  


<210> 18
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Cys Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu 
1               5                   10                  15      


Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val 
            20                  25                  30          


His Asn Phe 
        35  


<210> 19
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210> 20
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Cys 
            20                  25                  30          


<210> 21
<211> 567
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 21
atgcatcatc accatcatca cccgtgtcca gattcctctc ctttattgca attcggtggc       60

caagttcgtc aacgctacct gtataccgac gacgcccagc agaccgaagc gcaccttgag      120

atccgtgagg atggtacggt cggtggcgca gctgaccaaa gcccggagag cctgctgcag      180

ttgaaggccc tgaaaccggg tgttatccag attctgggtg tgaaaaccag ccgctttctg      240

tgccagcgtc cggatggcgc gctgtacggt agcctgcatt tcgacccgga agcgtgctct      300

tttcgcgagc tgctgctgga agatggctat aacgtgtacc aaagcgaagc gcacggtctg      360

ccgctgcatc tgccgggtaa taagagcccg caccgcgatc cggcaccgcg tggtccggct      420

cgtttcctgc cgttgccggg tctgccaccg gcgctgccgg agccgccagg cattctggca      480

ccgcagccgc ctgacgtcgg cagcagcgac ccgctgtcca tggttggtcc gagccagggc      540

cgtagcccgt cgtatgcgag ctgataa                                          567


<210> 22
<211> 188
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Met His His His His His His His Pro Cys Pro Asp Ser Ser Pro Leu 
1               5                   10                  15      


Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr Asp Asp 
            20                  25                  30          


Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly Thr Val 
        35                  40                  45              


Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu Lys Ala 
    50                  55                  60                  


Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys Thr Ser Arg Phe 
65                  70                  75                  80  


Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His Phe Asp 
                85                  90                  95      


Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly Tyr Asn 
            100                 105                 110         


Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro Gly Asn 
        115                 120                 125             


Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg Phe Leu 
    130                 135                 140                 


Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly Ile Leu 
145                 150                 155                 160 


Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val 
                165                 170                 175     


Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
            180                 185             


<210> 23
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 23
His His His His His His 
1               5       
