                         SEQUENCE LISTING

<110>  UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
 
<120>  Lactobacillus Acidophilus Surface Layer Protein A (SlpA) as a 
       Therapeutic Agent for the Treatment of Inflammatory Diseases

<130>  UF.1188XC1PCT

<150>  US 62/068,338
<151>  2014-10-24

<160>  55    

<170>  PatentIn version 3.5

<210>  1
<211>  686
<212>  PRT
<213>  Lactobacillus acidophilus


<220>
<221>  MISC_FEATURE
<223>  Amino acid sequence of phosphoglycerol transferase protein

<400>  1

Met Glu Arg Thr Lys Ser Phe Phe Lys Trp Leu Thr Gln Thr Lys Leu 
1               5                   10                  15      


Gly Phe Phe Thr Ile Val Leu Val Leu Phe Trp Leu Lys Thr Tyr Tyr 
            20                  25                  30          


Ile Tyr Leu Thr Lys Phe Asn Leu Gly Ala Val Gly Pro Met Gln Gln 
        35                  40                  45              


Phe Leu Leu Leu Ile Asn Pro Ile Pro Ser Gly Met Leu Leu Leu Gly 
    50                  55                  60                  


Ile Gly Leu Phe Phe Lys Gly Arg Lys Ser Tyr Trp Ile Ile Leu Ile 
65                  70                  75                  80  


Ile Asp Phe Leu Leu Thr Leu Trp Leu Phe Ser Asn Ile Leu Tyr Tyr 
                85                  90                  95      


Arg Glu Phe Ser Asn Phe Leu Ser Phe Ser Ile Ile Lys Thr Ser Gly 
            100                 105                 110         


Ser Thr Ser Asp Asn Leu Gly Lys Ser Ile Ala Gly Ile Thr Leu Ala 
        115                 120                 125             


Ser Asp Phe Leu Ala Phe Leu Asp Ile Ala Val Ile Ile Ala Leu Leu 
    130                 135                 140                 


Ala Thr Lys Val Ile Lys Met Asp Val Arg Pro Leu Lys Leu Lys Val 
145                 150                 155                 160 


Ser Leu Leu Ile Glu Phe Leu Ala Leu Ser Leu Met Gly Leu Asn Leu 
                165                 170                 175     


Leu Met Ala Gln Lys Asp Arg Ser Gly Leu Leu Thr Arg Thr Phe Asp 
            180                 185                 190         


Asn Asn Tyr Ile Val Lys Tyr Leu Gly Ile Asn Glu Tyr Ala Ile Tyr 
        195                 200                 205             


Asp Gly Tyr Lys Thr Ala Gln Thr Ser Ala Gln Met Ala Lys Ala Asn 
    210                 215                 220                 


Val Ser Asp Leu Lys Ser Val Arg Asn Tyr Leu Asn Ala Asn Lys Val 
225                 230                 235                 240 


Lys Pro Asn Pro Glu Tyr Thr Gly Val Ala Lys Gly Lys Asn Val Leu 
                245                 250                 255     


Val Ile His Leu Glu Ser Phe Gln Gln Phe Leu Ile Gly Tyr Lys Trp 
            260                 265                 270         


Lys Gly Lys Glu Val Thr Pro Asn Leu Asn Lys Ile Tyr His Gln Lys 
        275                 280                 285             


Asp Thr Ile Ser Phe Asp Asn Phe Phe Asn Gln Val Gly Gln Gly Lys 
    290                 295                 300                 


Thr Ser Asp Ala Glu Met Met Leu Glu Asn Ser Leu Tyr Gly Leu Gln 
305                 310                 315                 320 


Ser Gly Ser Ala Met Ser Thr Tyr Gly Thr Ser Asn Thr Phe Glu Ser 
                325                 330                 335     


Ala Pro Ala Ile Leu His Gln Gln Ala Gly Tyr Thr Thr Ala Val Met 
            340                 345                 350         


His Gly Gly Ala Gly Ser Phe Trp Asn Arg Asn Asn Ala Tyr Lys Ser 
        355                 360                 365             


Phe Gly Tyr Gln Tyr Phe Met Pro Leu Ser Phe Tyr Glu Asn Lys Pro 
    370                 375                 380                 


Ser Tyr Tyr Ile Gly Tyr Gly Leu Lys Asp Lys Ile Phe Phe Asp Gln 
385                 390                 395                 400 


Ser Ile Lys Tyr Ile Glu Arg Leu Pro Gln Pro Phe Tyr Leu Lys Met 
                405                 410                 415     


Ile Thr Val Thr Asn His Tyr Pro Tyr Asp Ile Asp Lys Lys Asn Gln 
            420                 425                 430         


Ser Ile Ala Lys Thr Asn Thr Gly Asp Glu Thr Val Asp Gly Tyr Val 
        435                 440                 445             


Gln Thr Ala His Tyr Leu Asp Gln Ala Ile Gly Glu Leu Met Ser Trp 
    450                 455                 460                 


Met Lys Lys Thr Gly Leu Asp Lys Lys Thr Leu Ile Val Phe Tyr Gly 
465                 470                 475                 480 


Asp His Tyr Gly Ile Ser Gly Asn His His Lys Ala Ser Ala Gln Leu 
                485                 490                 495     


Leu Lys Lys Lys Ser Phe Asn Asp Phe Asp Asn Leu Gln Phe Gln Arg 
            500                 505                 510         


Val Pro Leu Met Phe His Met Lys Gly Leu Lys Gly Gly Ile Asn His 
        515                 520                 525             


Thr Tyr Gly Gly Glu Ile Asp Val Leu Pro Thr Leu Leu Asn Leu Leu 
    530                 535                 540                 


Gly Ile Lys Asp Ser Asp Thr Ile Gln Phe Gly Tyr Asp Leu Leu Ser 
545                 550                 555                 560 


Lys Asn Ala Pro Gln Ile Val Ala Gln Arg Asn Gly Asp Phe Ile Thr 
                565                 570                 575     


Pro Glu Tyr Ser Lys Val Gly Ser Asp Tyr Tyr Tyr Thr Lys Thr Gly 
            580                 585                 590         


Lys Arg Ile Lys Pro Asn Lys Lys Leu Lys Ala Glu Leu Thr Ala Ile 
        595                 600                 605             


Ser Asn Thr Val Thr Thr Gln Leu Ser Leu Ser Asp Arg Val Ile Asn 
    610                 615                 620                 


Gly Asn Leu Leu Arg Phe Tyr Arg Pro Lys Trp Phe Thr Lys Val Lys 
625                 630                 635                 640 


Pro Lys Asp Tyr Asp Tyr Asn Lys Glu Pro Ser Leu Lys Arg Leu Phe 
                645                 650                 655     


Asn Asp Pro Ser Lys Thr Ser Leu Trp Tyr Gln Asn His Lys Lys Thr 
            660                 665                 670         


Thr Gln Lys Asp Phe Lys Thr Asp Ala Pro Glu Leu Lys Lys 
        675                 680                 685     


<210>  2
<211>  457
<212>  PRT
<213>  Lactobacillus acidophilus


<220>
<221>  MISC_FEATURE
<223>  Amino acid sequence of SlpB protein

<400>  2

Met Lys Lys Asn Leu Arg Ile Val Ser Ala Ala Ala Ala Ala Leu Leu 
1               5                   10                  15      


Ala Val Ala Pro Val Ala Ala Ser Ala Val Ser Thr Val Asn Ala Ala 
            20                  25                  30          


Ala Val Asn Ala Ile Ala Val Gly Gly Ser Ala Thr Pro Leu Pro Asn 
        35                  40                  45              


Asn Ser Asp Val Gln Ile Ser Ser Ser Val Ala Gly Val Thr Thr Lys 
    50                  55                  60                  


Asn Gly Ser Ser Tyr Thr Asn Gly Arg Ile Ser Gly Ser Ile Asn Ala 
65                  70                  75                  80  


Ser Tyr Asn Gly Thr Ser Tyr Ser Ala Asn Phe Ser Ser Ser Asn Ala 
                85                  90                  95      


Gly Val Val Val Ser Thr Pro Gly His Thr Glu Leu Ser Gly Glu Gln 
            100                 105                 110         


Ile Asn Gly Leu Glu Pro Gly Ser Ala Val Thr Val Thr Leu Arg Asp 
        115                 120                 125             


Gly Val Ser Phe Asn Phe Gly Ser Thr Asn Ala Asn Lys Thr Ile Thr 
    130                 135                 140                 


Leu Ala Phe Pro Lys Asn Val Ser Ala Ala Gly Leu Ala Asp Ala Asn 
145                 150                 155                 160 


Lys Val Ser Ala Thr Ser Glu Thr Ser Val Asp Ala Gly Lys Thr Ile 
                165                 170                 175     


Gln Val Lys Thr Asp Lys Asn Gly Val Val Ser Phe Gly Ser Ala Gln 
            180                 185                 190         


Val Leu Asn Val Lys Val Val Glu Thr Ser Asp Val Arg Ala Val Ser 
        195                 200                 205             


Phe Tyr Asp Ile Gln Thr Gly Lys Thr Val Glu Asn Gly Thr Leu Ser 
    210                 215                 220                 


Ile Val Ala Gly Ser Asn Ala Arg Ala Asn Val Gln Glu Ile Val Asn 
225                 230                 235                 240 


Ala Phe Asn Ala Lys Tyr Gln Ala Ser Gln Leu Asn Asn Ala Asn Ser 
                245                 250                 255     


Asn Ala Asn Val Arg Leu Thr Asp Asn Asn Ala Gln Ala Val Ala Thr 
            260                 265                 270         


Met Leu Arg Ala Gln Asn Ile Asp Val Asp Ala Gln Gly Tyr Phe Thr 
        275                 280                 285             


Ala Pro Ala Ser Leu Ser Leu Thr Phe His Ala Glu Ser Thr Gln Asn 
    290                 295                 300                 


Asn Glu Thr Ala Gln Leu Pro Val Thr Val Ser Val Thr Asn Gly Lys 
305                 310                 315                 320 


Glu Val Thr Pro Ser Thr Val Asp Ser Val Ser Lys Arg Ile Met His 
                325                 330                 335     


Asn Ala Tyr Tyr Tyr Asp Lys Asp Ala Lys Arg Val Gly Thr Asp Ser 
            340                 345                 350         


Val Lys Arg Tyr Asn Ser Val Ser Val Leu Pro Asn Thr Thr Thr Ile 
        355                 360                 365             


Asn Gly Lys Ala Tyr Tyr Gln Val Val Glu Asn Gly Lys Ala Val Asp 
    370                 375                 380                 


Lys Tyr Ile Asn Ala Ala Asn Ile Asp Gly Thr Lys Arg Thr Leu Lys 
385                 390                 395                 400 


His Asn Ala Tyr Val Tyr Ala Ser Ser Lys Lys Arg Ala Asn Lys Val 
                405                 410                 415     


Val Leu Lys Lys Gly Glu Val Val Thr Thr Tyr Gly Ala Ser Tyr Thr 
            420                 425                 430         


Phe Lys Asn Gly Gln Lys Tyr Tyr Lys Ile Gly Asp Asn Thr Asp Lys 
        435                 440                 445             


Thr Tyr Val Lys Val Ala Asn Phe Arg 
    450                 455         


<210>  3
<211>  499
<212>  PRT
<213>  Lactobacillus acidophilus


<220>
<221>  MISC_FEATURE
<223>  Amino acid sequence of SlpX protein

<400>  3

Met Lys Lys Asn Arg Lys Met Leu Gly Leu Ala Ala Ala Thr Leu Leu 
1               5                   10                  15      


Ala Val Ala Pro Val Ala Thr Ser Val Val Pro Val Gln Ala Asp Thr 
            20                  25                  30          


Ala Val Asn Val Gly Ser Ala Ala Gly Thr Gly Ala Asn Thr Thr Asn 
        35                  40                  45              


Thr Thr Thr Gln Ala Pro Gln Asn Lys Pro Tyr Phe Thr Tyr Asn Asn 
    50                  55                  60                  


Glu Ile Ile Gly Glu Ala Thr Gln Ser Asn Pro Leu Gly Asn Val Val 
65                  70                  75                  80  


Arg Thr Thr Ile Ser Phe Lys Ser Asp Asp Lys Val Ser Asp Leu Ile 
                85                  90                  95      


Ser Thr Ile Ser Lys Ala Val Gln Phe His Lys Asn Asn Ser Ala Ser 
            100                 105                 110         


Gly Glu Asn Val Thr Ile Asn Glu Asn Asp Phe Ile Asn Gln Leu Lys 
        115                 120                 125             


Ala Asn Gly Val Thr Val Lys Thr Val Gln Pro Ser Asn Lys Asn Glu 
    130                 135                 140                 


Lys Ala Tyr Glu Ala Ile Asp Lys Val Pro Ser Thr Ser Phe Asn Ile 
145                 150                 155                 160 


Thr Leu Ser Ala Thr Gly Asp Asn Asn Gln Thr Ala Thr Ile Gln Ile 
                165                 170                 175     


Pro Met Val Pro Gln Gly Ala Ser Thr Pro Thr Asp Thr Thr Gln Asn 
            180                 185                 190         


Pro Gln Ile Asn Trp Thr Lys Gly Gly Gln Ala Gln Ser Ser Ser Leu 
        195                 200                 205             


Asn Gly Gln Val Phe Gln Val Ala Val Gly Ser Asn Phe Asn Pro Leu 
    210                 215                 220                 


Asn Phe Thr Asn Ser Asn Gly Glu Asn Ile Ile Val Ser Ala Gln Gln 
225                 230                 235                 240 


Ser Lys Asn Asn Thr Thr Phe Ala Ser Ile Glu Ala Thr Ser Asn Pro 
                245                 250                 255     


Val Asn Thr Ser Glu Ala Gly Arg Tyr Tyr Asn Val Thr Leu Thr Ala 
            260                 265                 270         


Thr Gly Asn Thr Gly Lys Lys Thr Thr Ala Thr Tyr Thr Val Leu Ile 
        275                 280                 285             


Thr Ser Ser Gln Lys Gln Thr Leu Tyr Gly Asn Gly Glu Ser Thr Ile 
    290                 295                 300                 


Ser Thr Tyr Ser Ile Tyr Gly Asn Asn Val Leu Ser Asn Ser Thr Thr 
305                 310                 315                 320 


Phe Lys Asp Gly Asp Gln Val Tyr Val Ser Asp Gln Thr Lys Thr Val 
                325                 330                 335     


Gly Gly Val Ser Tyr Ser Gln Val Ser Pro Lys Ser Lys Asn Asp Ala 
            340                 345                 350         


Asn Ser Ser Asn Ile Trp Val Lys Thr Ser Ala Leu Val Lys Pro Ala 
        355                 360                 365             


Gly Asp Thr Asn Val Lys Thr Tyr Pro Val Met Val Asp Ser Arg Ala 
    370                 375                 380                 


Tyr Asp Lys Asn Gly Asn Tyr Leu Gly His Met Tyr Tyr Ala Tyr Asp 
385                 390                 395                 400 


Asn Ile Asp Ile Val Pro Thr Val Val Thr Ile Asn Gly Lys Thr Tyr 
                405                 410                 415     


Tyr Lys Val Ala Asn Lys Asp Glu Tyr Val Arg Val Thr Asn Ile Thr 
            420                 425                 430         


Gly Asn Gln Arg Thr Leu Lys His Asn Ala Tyr Ile Tyr Trp Ser Ser 
        435                 440                 445             


Tyr Arg Arg Thr Pro Gly Thr Gly Lys Met Tyr Arg Gly Gln Thr Val 
    450                 455                 460                 


Thr Thr Tyr Gly Pro Gln Met Lys Phe Lys Asn Gly Lys Lys Tyr Tyr 
465                 470                 475                 480 


Arg Ile Glu Gly Cys Arg Asn Asn Asn Lys Arg Tyr Ile Lys Ala Val 
                485                 490                 495     


Asn Phe Tyr 
            


<210>  4
<211>  444
<212>  PRT
<213>  Lactobacillus acidophilus


<220>
<221>  MISC_FEATURE
<223>  Amino acid sequence of SlpA protein

<400>  4

Met Lys Lys Asn Leu Arg Ile Val Ser Ala Ala Ala Ala Ala Leu Leu 
1               5                   10                  15      


Ala Val Ala Pro Val Ala Ala Ser Ala Val Ser Thr Val Ser Ala Ala 
            20                  25                  30          


Thr Thr Ile Asn Ala Ser Ser Ser Ala Ile Asn Thr Asn Thr Asn Ala 
        35                  40                  45              


Lys Tyr Asp Val Asp Val Thr Pro Ser Val Ser Ala Val Ala Ala Asn 
    50                  55                  60                  


Thr Ala Asn Asn Thr Pro Ala Ile Ala Gly Asn Leu Thr Gly Thr Ile 
65                  70                  75                  80  


Ser Ala Ser Tyr Asn Gly Lys Thr Tyr Thr Ala Asn Leu Lys Ala Asp 
                85                  90                  95      


Thr Glu Asn Ala Thr Ile Thr Ala Ala Gly Ser Thr Thr Ala Val Lys 
            100                 105                 110         


Pro Ala Glu Leu Ala Ala Gly Val Ala Tyr Thr Val Thr Val Asn Asp 
        115                 120                 125             


Val Ser Phe Asn Phe Gly Ser Glu Asn Ala Gly Lys Thr Val Thr Leu 
    130                 135                 140                 


Gly Ser Ala Asn Ser Asn Val Lys Phe Thr Gly Thr Asn Ser Asp Asn 
145                 150                 155                 160 


Gln Thr Glu Thr Asn Val Ser Thr Leu Lys Val Lys Leu Asp Gln Asn 
                165                 170                 175     


Gly Val Ala Ser Leu Thr Asn Val Ser Ile Ala Asn Val Tyr Ala Ile 
            180                 185                 190         


Asn Thr Thr Asp Asn Ser Asn Val Asn Phe Tyr Asp Val Thr Ser Gly 
        195                 200                 205             


Ala Thr Val Thr Asn Gly Ala Val Ser Val Asn Ala Asp Asn Gln Gly 
    210                 215                 220                 


Gln Val Asn Val Ala Asn Val Val Ala Ala Ile Asn Ser Lys Tyr Phe 
225                 230                 235                 240 


Ala Ala Gln Tyr Ala Asp Lys Lys Leu Asn Thr Arg Thr Ala Asn Thr 
                245                 250                 255     


Glu Asp Ala Ile Lys Ala Ala Leu Lys Asp Gln Lys Ile Asp Val Asn 
            260                 265                 270         


Ser Val Gly Tyr Phe Lys Ala Pro His Thr Phe Thr Val Asn Val Lys 
        275                 280                 285             


Ala Thr Ser Asn Thr Asn Gly Lys Ser Ala Thr Leu Pro Val Val Val 
    290                 295                 300                 


Thr Val Pro Asn Val Ala Glu Pro Thr Val Ala Ser Val Ser Lys Arg 
305                 310                 315                 320 


Ile Met His Asn Ala Tyr Tyr Tyr Asp Lys Asp Ala Lys Arg Val Gly 
                325                 330                 335     


Thr Asp Ser Val Lys Arg Tyr Asn Ser Val Ser Val Leu Pro Asn Thr 
            340                 345                 350         


Thr Thr Ile Asn Gly Lys Thr Tyr Tyr Gln Val Val Glu Asn Gly Lys 
        355                 360                 365             


Ala Val Asp Lys Tyr Ile Asn Ala Ala Asn Ile Asp Gly Thr Lys Arg 
    370                 375                 380                 


Thr Leu Lys His Asn Ala Tyr Val Tyr Ala Ser Ser Lys Lys Arg Ala 
385                 390                 395                 400 


Asn Lys Val Val Leu Lys Lys Gly Glu Val Val Thr Thr Tyr Gly Ala 
                405                 410                 415     


Ser Tyr Thr Phe Lys Asn Gly Gln Lys Tyr Tyr Lys Ile Gly Asp Asn 
            420                 425                 430         


Thr Asp Lys Thr Tyr Val Lys Val Ala Asn Phe Arg 
        435                 440                 


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  111b Forward primer sequence

<400>  5
aaggagaacc aagcaacgac                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  111b Reverse primer sequence

<400>  6
gagattgagc tgtctgctca                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ocln Forward primer sequence

<400>  7
gctgtgatgt gtgtgagctg                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ocln Reverse primer sequence

<400>  8
gacggtctac ctggaggaac                                                   20


<210>  9
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cd209a Forward primer sequence

<400>  9
tctggattca gtagcttcac agg                                               23


<210>  10
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cd209a Reverse primer sequence

<400>  10
gggtcagttc ttggtagaca ttc                                               23


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cd209b Forward primer sequence

<400>  11
ttgatggtca gcggcagcag g                                                 21


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cd209b Reverse primer sequence

<400>  12
tcagcaggag cccagccaag a                                                 21


<210>  13
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cd209c Forward primer sequence

<400>  13
ctggaatgac tctgtcaatg cc                                                22


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cd209c Reverse primer sequence

<400>  14
gccatctgcc ttcatgcttc a                                                 21


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cd209d Forward primer sequence

<400>  15
gggcccaact ggtcatcata                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cd209d Reverse primer sequence

<400>  16
agcgtgtaaa gctgggtgac                                                   20


<210>  17
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cd209e Forward primer sequence

<400>  17
ccacattccc ctggtgttg                                                    19


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cd209e Reverse primer sequence

<400>  18
cagaggcgac agagtctatc a                                                 21


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cd209f Forward primer sequence

<400>  19
ctctttgggc ctctttttgc t                                                 21


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cd209f Reverse primer sequence

<400>  20
agtatgcacg aatcctggag a                                                 21


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cd209g Forward primer sequence

<400>  21
ggcctcagcg atcacagaag                                                   20


<210>  22
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cd209g Reverse primer sequence

<400>  22
acaacggctg tcattccatt ta                                                22


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Muc2 Forward primer sequence

<400>  23
gtgtgggacc tgacaatgtg                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Muc2 Reverse primer sequence

<400>  24
acaacgaggt aggtgccatc                                                   20


<210>  25
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Muc3 Forward primer sequence

<400>  25
gccgtgaatt gtatgaacgg a                                                 21


<210>  26
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Muc3 Reverse primer sequence

<400>  26
cgcagttgac cacgttgact a                                                 21


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tjp1 Forward primer sequence

<400>  27
aggacaccaa agcatgtgag                                                   20


<210>  28
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tjp1 Reverse primer sequence

<400>  28
ggcattcctg ctggttaca                                                    19


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tjp2 Forward primer sequence

<400>  29
atgggagcag tacaccgtga                                                   20


<210>  30
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tjp2 Reverse primer sequence

<400>  30
tgaccaccct gtcattttct tg                                                22


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tjp3 Forward primer sequence

<400>  31
tcggcatagc tgtctctgga                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tjp3 Reverse primer sequence

<400>  32
gttggctgtt ttggtgcagg                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cldn1 Forward primer sequence

<400>  33
tccttgttcg gctatgtgtc                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cldn1 Reverse primer sequence

<400>  34
ggcatgcacc taagaatcag                                                   20


<210>  35
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cldn2 Forward primer sequence

<400>  35
ggctgttagg cacatccat                                                    19


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cldn2 Reverse primer sequence

<400>  36
tggcaccaac ataggaactc                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cldn3 Forward primer sequence

<400>  37
tggcaccaac ataggaactc                                                   20


<210>  38
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cldn3 Reverse primer sequence

<400>  38
ctggcaagta gctgcagtg                                                    19


<210>  39
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cldn5 Forward primer sequence

<400>  39
gcaaggtgta tgaatctgtg ct                                                22


<210>  40
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cldn5 Reverse primer sequence

<400>  40
gtcaaggtaa caaagagtgc ca                                                22


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cldn8 Forward primer sequence

<400>  41
gccggaatca tcttcttcat                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cldn8 Reverse primer sequence

<400>  42
catccaccag tgggttgtag                                                   20


<210>  43
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hsp25 Forward primer sequence

<400>  43
ggttgcccga tgagtggtc                                                    19


<210>  44
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hsp25 Reverse primer sequence

<400>  44
ctgagctgtc ggttgagcg                                                    19


<210>  45
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hsp72 Forward primer sequence

<400>  45
ctccctcttg cgttgcctc                                                    19


<210>  46
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hsp72 Forward primer sequence

<400>  46
acccgcagta atagccatct g                                                 21


<210>  47
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SlpA protein sequence

<400>  47

Ala Ala Thr Thr Ile Asn Ala Ser Ser Ser Ala Ile Asn Thr Asn Thr 
1               5                   10                  15      


Asn Ala Lys Tyr Asp Val Asp Val Thr Pro Ser Val Ser Ala Val Ala 
            20                  25                  30          


Ala Val Ala Ala Asn Thr Ala Asn Asn Thr Pro Ala Ile Ala Gly Asn 
        35                  40                  45              


Leu Thr Gly Thr Ile Ser Ala Ser Tyr Asn Gly Lys Thr Tyr Thr Ala 
    50                  55                  60                  


Asn Leu Lys Ala Asp Thr Glu Asn Ala Thr Ile Thr Ala Ala Gly Ser 
65                  70                  75                  80  


Thr Thr Ala Val Lys Pro Ala Glu Leu Ala Ala Gly Val Ala Tyr Thr 
                85                  90                  95      


Val Thr Val Asn Asp Val Ser Phe Asn Phe Gly Ser Glu Asn Ala Gly 
            100                 105                 110         


Lys Thr Val Thr Leu Gly Ser Ala Asn Ser Asn Val Lys Phe Thr Gly 
        115                 120                 125             


Thr Asn Ser Asp Asn Gln Thr Glu Thr Asn Val Ser Thr Leu Lys Val 
    130                 135                 140                 


Lys Leu Asp Gln Asn Gly Val Ala Ser Leu Thr Asn Val Ser Ile Ala 
145                 150                 155                 160 


Asn Val Tyr Ala Ile Asn Thr Thr Asp Asn Ser Asn Val Asn Phe Tyr 
                165                 170                 175     


Asp Val Thr Ser Gly Ala Thr Val Thr Asn Gly Ala Val Ser Val Asn 
            180                 185                 190         


Ala Asp Asn Gln Gly Gln Val Asn Val Ala Asn Val Val Ala Ala Ile 
        195                 200                 205             


Asn Ser Lys Tyr Phe Ala Ala Gln Tyr Ala Asp Lys Lys Leu Asn Thr 
    210                 215                 220                 


Arg Thr Ala Asn Thr Glu Asp Ala Ile Lys Ala Ala Leu Lys Asp Gln 
225                 230                 235                 240 


Lys Ile Asp Val Asn Ser Val Gly Tyr Phe Lys Ala Pro His Thr Phe 
                245                 250                 255     


Thr Val Asn Val Lys Ala Thr Ser Asn Thr Asn Gly Lys Ser Ala Thr 
            260                 265                 270         


Leu Pro Val Val Val Thr Val Pro Asn Val Ala Glu Pro Thr Val Ala 
        275                 280                 285             


<210>  48
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SlpA protein sequence

<400>  48

Met Lys Lys Asn Leu Arg Ile Val Ser Ala Ala Ala Ala Ala Leu Leu 
1               5                   10                  15      


Ala Val Ala Pro Val Ala Ala Ser Ala Val Ser Thr Val Ser Ala Ala 
            20                  25                  30          


Thr Thr Ile Asn Ala Ser Ser Ser Ala Ile Asn Thr Asn Thr Asn Ala 
        35                  40                  45              


Lys Tyr Asp Val Asp Val Thr Pro Ser Val Ser Ala Val Ala Ala Asn 
    50                  55                  60                  


Thr Ala Asn Asn Thr Pro Ala Ile Ala Gly Asn Leu Thr Gly Thr Ile 
65                  70                  75                  80  


Ser Ala Ser Tyr Asn Gly Lys Thr Tyr Thr Ala Asn Leu Lys Ala Asp 
                85                  90                  95      


Thr Glu Asn Ala Thr Ile Thr Ala Ala Gly Ser Thr Thr Ala Val Lys 
            100                 105                 110         


Pro Ala Glu Leu Ala Ala Gly Val Ala Tyr Thr Val Thr Val Asn Asp 
        115                 120                 125             


Val Ser Phe Asn Phe Gly Ser Glu Asn Ala Gly Lys Thr Val Thr Leu 
    130                 135                 140                 


Gly Ser Ala Asn Ser Asn Val Lys Phe Thr Gly Thr Asn Ser Asp Asn 
145                 150                 155                 160 


Gln Thr Glu Thr Asn Val Ser Thr Leu Lys Val Lys Leu Asp Gln Asn 
                165                 170                 175     


Gly Val Ala Ser Leu Thr Asn Val Ser Ile Ala Asn Val Tyr Ala Ile 
            180                 185                 190         


Asn Thr Thr Asp Asn Ser Asn Val Asn Phe Tyr Asp Val Thr Ser Gly 
        195                 200                 205             


Ala Thr Val Thr Asn Gly Ala Val Ser Val Asn Ala Asp Asn Gln Gly 
    210                 215                 220                 


Gln Val Asn Val Ala Asn Val Val Ala Ala Ile Asn Ser Lys Tyr Phe 
225                 230                 235                 240 


Ala Ala Gln Tyr Ala Asp Lys Lys Leu Asn Thr Arg Thr Ala Asn Thr 
                245                 250                 255     


Glu Asp Ala Ile Lys Ala Ala Leu Lys Asp Gln Lys Ile Asp Val Asn 
            260                 265                 270         


Ser Val Gly Tyr Phe Lys Ala Pro His Thr Phe Thr Val Asn Val Lys 
        275                 280                 285             


Ala Thr Ser Asn Thr Asn Gly Lys Ser Ala Thr Leu Pro Val Val Val 
    290                 295                 300                 


Thr Val Pro Asn Val Ala Glu Pro Thr Val Ala Ser Val Ser Lys Arg 
305                 310                 315                 320 


Ile Met His Asn Ala Tyr Tyr Tyr Asp Lys Asp Ala Lys Arg Val Gly 
                325                 330                 335     


Thr Asp Ser Val Lys Arg Tyr Asn Ser Val Ser Val Leu Pro Asn Thr 
            340                 345                 350         


Thr Thr Ile Asn Gly Lys Thr Tyr Tyr Gln Val Val Glu Asn Gly Lys 
        355                 360                 365             


Ala Val Asp Lys Tyr Ile Asn Ala Ala Asn Ile Asp Gly Thr Lys Arg 
    370                 375                 380                 


Thr Leu Lys His Asn Ala Tyr Val Tyr Ala Ser Ser Lys Lys Arg Ala 
385                 390                 395                 400 


Asn Lys Val Val Leu Lys Lys Gly Glu Val Val Thr Thr Tyr Gly Ala 
                405                 410                 415     


Ser Tyr Thr Phe Lys Asn Gly Gln Lys Tyr Tyr Lys Ile Gly Asp Asn 
            420                 425                 430         


Thr Asp Lys Thr Tyr Val Lys Val Ala Asn Phe Arg 
        435                 440                 


<210>  49
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SlpA protein sequence

<400>  49

Met Phe Gly Gly Arg Lys Ile Met Gln Ser Ser Leu Lys Lys Ser Leu 
1               5                   10                  15      


Tyr Leu Gly Leu Ala Ala Leu Ser Phe Ala Gly Val Ala Ala Val Ser 
            20                  25                  30          


Thr Thr Ala Ser Ala Lys Ser Tyr Ala Thr Ala Gly Ala Tyr Thr Thr 
        35                  40                  45              


Leu Lys Thr Asp Ala Thr Lys Arg Asn Val Glu Ala Thr Gly Thr Asn 
    50                  55                  60                  


Ala Leu Tyr Thr Lys Pro Gly Thr Val Lys Gly Ala Lys Val Val Ala 
65                  70                  75                  80  


Ser Lys Ala Thr Met Ala Lys Leu Ala Ser Ser Lys Lys Ser Ala Asp 
                85                  90                  95      


Tyr Phe Arg Ala Tyr Gly Val Lys Thr Thr Asn Arg Gly Ser Val Tyr 
            100                 105                 110         


Tyr Arg Val Val Ser Met Asp Gly Lys Tyr Arg Gly Tyr Val Tyr Gly 
        115                 120                 125             


Gly Lys Ser Asp Thr Ala Phe Ala Gly Gly Ile Lys Ser Ala Asp Thr 
    130                 135                 140                 


Thr Thr Thr Ala Thr Thr Pro Thr Arg Thr Thr Gly Tyr Tyr Leu Lys 
145                 150                 155                 160 


Asp Val Ser Lys Asn Thr Leu Trp Thr Ala Pro Lys Asn Thr Gln Tyr 
                165                 170                 175     


Lys Ala Ser Lys Val Ser Leu Tyr Gly Val Lys Ser Thr Asp Thr Phe 
            180                 185                 190         


Lys Val Asp Ser Ala Ala Thr Lys Thr Arg Glu Gly Ser Leu Tyr Tyr 
        195                 200                 205             


His Val Thr Asp Thr Gln Asn Thr Ser Val Ser Gly Trp Ile Tyr Ala 
    210                 215                 220                 


Gly Lys Gly Tyr Val Ala Gly Ala Thr Thr Gln Asp Leu Gly Gly Leu 
225                 230                 235                 240 


Ser Leu Thr Met Ser Asp Ala Ala Ala Thr Ser Asp Asn Ser Val Lys 
                245                 250                 255     


Val Val Tyr Arg Ala Ser Gly Ser Gln Val Gly Thr Ala Thr Trp Val 
            260                 265                 270         


Thr Ala Ala Ala Gly Thr Lys Ala Gly Ala Thr Val Gly Thr Thr Ala 
        275                 280                 285             


Val Asn Ala Ala Gly Val Lys Leu Ala Asp Phe Val Thr Asn Ser Leu 
    290                 295                 300                 


Pro Ser Gly Tyr Thr Thr Thr Gly Thr Val Asp Thr Ala Ser Ala Thr 
305                 310                 315                 320 


Tyr Gly Asn Thr Val Tyr Val Asp Val Thr Ala Ala Ala Thr Ser Lys 
                325                 330                 335     


Val Gln Leu Val Ala Asp Asn Val Asp Asn Thr Ala Ser Thr Thr Asp 
            340                 345                 350         


Asn Ala Val Ala Gly Val Leu Ala Asn Gly Ala Lys Leu Ser Ser Ser 
        355                 360                 365             


Asp Leu Ser Ala Thr Leu Lys Glu Ala Gly Ile Lys Ala Leu Thr Gly 
    370                 375                 380                 


Thr Lys Gly Glu Ala Ile Gly Ala Thr Asn Leu Ala Thr Ile Ser Gly 
385                 390                 395                 400 


Ala Phe Asp Thr Ala Glu Ile Asn Gly Ser Lys Thr Tyr Tyr Ala Ala 
                405                 410                 415     


Asn Gly Asp Ala Tyr His Tyr Val Phe Thr Tyr Glu Pro Ala Asn Phe 
            420                 425                 430         


Ala Asn Asp Asn Arg Leu Ala Thr Tyr Gly Asp Thr Leu Thr Ala Ser 
        435                 440                 445             


Phe Lys Ala Val Leu Thr Lys Gly Ala Pro Ser Ala Ser Ser Ser Asn 
    450                 455                 460                 


Ser Ser Trp Ile Ala 
465                 


<210>  50
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SlpA protein sequence

<400>  50

Met Lys Lys Asn Leu Arg Ile Val Ser Ala Ala Ala Ala Ala Leu Leu 
1               5                   10                  15      


Ala Val Ala Pro Val Ala Ala Ser Ala Val Ser Val Asn Ala Ala Asp 
            20                  25                  30          


Asn Thr Val Ala Thr Thr Thr Asn Thr Ala Asn Thr Val Ile Asn Ala 
        35                  40                  45              


Asp Gly Thr Ala Ile Asn Thr Pro Ala Asp Ala Lys Tyr Asp Val Asp 
    50                  55                  60                  


Val Thr Pro Asn Leu Thr Ala Thr Ala Ala Ser Thr Val Asn Gly Gln 
65                  70                  75                  80  


Thr Ile Asn Gly Ser Ile Thr Gly Asn Ile Thr Ala Ser Tyr Asn Gly 
                85                  90                  95      


Gln Ser Tyr Thr Gly Thr Leu Asp Thr Lys Asn Gly Lys Val Ser Val 
            100                 105                 110         


Ala Asp Ser Lys Gly Thr Ala Val Thr Asp Phe Ser Lys Leu Thr Asn 
        115                 120                 125             


Gly Ser Tyr Thr Val Thr Val Ser Gly Val Ser Phe Asn Phe Gly Thr 
    130                 135                 140                 


Ala Asn Ala Asn Lys Thr Ile Thr Leu Gly Ser Lys Asn Ser Asn Val 
145                 150                 155                 160 


Lys Phe Ala Gly Ala Asp Gly Lys Phe Ala Asp Thr Val Lys Val Glu 
                165                 170                 175     


Leu Gly Gln Asn Gly Thr Leu Thr Thr Pro Ile Ser Val Gln Val Ser 
            180                 185                 190         


Asn Val Asn Ala Leu Asp Leu Ser Asn Ala Asn Gly Val Asn Phe Tyr 
        195                 200                 205             


Asn Ala Ser Asn Gly Ser Gln Val Thr Lys Gly Ser Val Asn Val Thr 
    210                 215                 220                 


Ala Gly Leu Ile Gly Arg Leu Asn Val Ser Thr Val Ala Ser Glu Ile 
225                 230                 235                 240 


Leu Lys Asn Cys Ala Ala Tyr Gln Val Ser Asn Gly Lys Pro Val Ser 
                245                 250                 255     


Gln Leu Pro Asp Gln Lys Ala Val Val Ala Asp Val Asn Ala Ala Leu 
            260                 265                 270         


Lys Ala Ala Asn Ile Pro Val Asp Asn Ala Gly Trp Phe Thr Ala Pro 
        275                 280                 285             


Ile Ser Leu Ser Val Asn Val Lys Ala Ser Ser Ser Ile Asn Gly Val 
    290                 295                 300                 


Gly Cys Tyr Phe Thr Cys Thr Val Asn Val Ala Asn Gly Lys Asp Met 
305                 310                 315                 320 


Thr Val Pro Ser Gln Ser Lys Thr Ile Met His Asn Ala Tyr Tyr Tyr 
                325                 330                 335     


Asp Lys Asp Ala Lys Arg Val Gly Thr Asp Lys Leu Thr Arg Tyr Asn 
            340                 345                 350         


Ser Val Thr Val Ala Met Asn Thr Thr Thr Ile Asn Gly Lys Ala Tyr 
        355                 360                 365             


Tyr Glu Val Ile Glu Asn Gly Lys Ala Thr Gly Lys Phe Ile Asn Ala 
    370                 375                 380                 


Asp Asn Ile Asp Gly Thr Lys Arg Thr Leu Lys His Asn Ala Tyr Val 
385                 390                 395                 400 


Tyr Lys Thr Ser Lys Lys Arg Ala Asn Lys Val Thr Leu Lys Lys Gly 
                405                 410                 415     


Thr Glu Val Thr Thr Tyr Gly Gly Thr Tyr Thr Phe Lys Asn Gly Lys 
            420                 425                 430         


Gln Tyr Tyr Lys Ile Gly Asn Asn Thr Asp Lys Thr Tyr Val Lys Ala 
        435                 440                 445             


Ser Asn Phe 
    450     


<210>  51
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SlpA protein sequence

<400>  51

Met Lys Lys Asn Leu Arg Ile Val Ser Ala Ala Ala Ala Ala Leu Leu 
1               5                   10                  15      


Ala Val Ala Pro Val Ala Ala Ala Gly Val Ser Ser Val Thr Ala Ser 
            20                  25                  30          


Ser Ile Glu Phe Val Gly Ser Ser Asn Ser Ser Leu Leu Pro Glu Val 
        35                  40                  45              


Asn Asp His Thr Val Asn Phe Gly Ile Asn Phe Asn Ala Ile Gly Ala 
    50                  55                  60                  


Tyr Gly Asn Val Pro Ser Ser Val Ser Ala Thr Ala Glu Val Thr Ile 
65                  70                  75                  80  


Asn Gly Gln Lys Thr Thr Ile Asn Leu Pro Glu Asn Gln Lys Ser Tyr 
                85                  90                  95      


Ile Tyr Tyr Ala Thr Thr Asn Glu Ser Val Asp Ala Ser Lys Leu Val 
            100                 105                 110         


Ala Gly Gln Lys Tyr Tyr Thr Gly Ile Asn Asn Ala Ser Leu Asn Leu 
        115                 120                 125             


Gly Ser Pro Asn His Asp Lys Asp Ile Thr Leu Glu Gly Ser Asn Val 
    130                 135                 140                 


Ser Phe Lys Thr Asn Asp Ser Asp Pro Tyr Thr Lys Thr Leu Lys Val 
145                 150                 155                 160 


Asn Thr Asp Lys Asn Gly Val Ile Ser Asn Leu Ser Ile Lys Ser Ala 
                165                 170                 175     


Asn Phe Asp Ala Val Asp Val Asn Asn Ala Arg Thr Val Ser Phe Tyr 
            180                 185                 190         


Asp Ala Asp Thr Gly Asn Ile Val Thr Ser Gly Ala Leu Glu Ile Asn 
        195                 200                 205             


Ala Gly Pro Asn Ala Gln Met Asn Val Gln Thr Ile Leu Ala Lys Phe 
    210                 215                 220                 


Glu Gln Lys Tyr Gln Ala Ala Gln Leu Asn Asn Ala Gly Thr Thr Asn 
225                 230                 235                 240 


Asn Val Ser Tyr Asn Asn Asp Leu Ile Ser Thr Thr Pro Ala Asp Leu 
                245                 250                 255     


Ala Ala Gln Leu Lys Lys Ala Gly Tyr Ser Val Asp Asn Asn Gly Tyr 
            260                 265                 270         


Phe Thr Ala Lys His Ser Phe Thr Val Asn Phe Ser Ala Lys Ser Gly 
        275                 280                 285             


Gln Asn Gly Tyr Thr Thr Thr Met Pro Val Thr Val Thr Val Pro Asn 
    290                 295                 300                 


Val Ala Glu Glu Thr Val Pro Ser Gln Ile Arg Thr Val Met His Asn 
305                 310                 315                 320 


Ala Phe Phe Tyr Asp Lys Asn Gly Lys Arg Val Gly Ser Asp Lys Val 
                325                 330                 335     


Thr Arg Tyr Asn Ser Ala Thr Val Ala Met Asn Thr Thr Thr Ile Ile 
            340                 345                 350         


Gly Lys Ala Tyr Tyr Glu Val Ile Glu Asn Gly Lys Ala Thr Gly Lys 
        355                 360                 365             


Phe Ile Asn Ala Ala Asn Ile Asp Gly Thr Lys Arg Thr Leu Lys His 
    370                 375                 380                 


Asn Ala Tyr Val Tyr Lys Ser Ser Lys Lys Arg Ala Asn Lys Val Val 
385                 390                 395                 400 


Leu Lys Lys Gly Glu Thr Val Val Thr Tyr Gly Gly Ala Tyr Thr Phe 
                405                 410                 415     


Lys Asn Gly Lys Gln Tyr Tyr Lys Ile Gly Asn Asn Thr Asp Lys Thr 
            420                 425                 430         


Tyr Val Lys Val Ala Asn Phe 
        435                 


<210>  52
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SlpA protein sequence

<400>  52

Met Lys Lys Asn Leu Arg Ile Val Ser Ala Ala Ala Ala Ala Leu Leu 
1               5                   10                  15      


Ala Val Ala Pro Val Ala Ala Ser Ala Val Ser Val Asn Ala Ala Ser 
            20                  25                  30          


Ser Ser Ala Val Gln Thr Ala Thr Asn Ile Gly Thr Val Leu Pro Leu 
        35                  40                  45              


Thr Asp Gly Ser Thr Val Asn Val Lys Pro Asn Ile Ser Leu Asn Thr 
    50                  55                  60                  


Ser Ala Tyr Glu Gly Val Lys Ala Asn Ile Ser Val Ser Phe Ser Ala 
65                  70                  75                  80  


Thr Val Asp Gly Thr Thr Ala Thr Ser Asn Phe Thr Pro Asn Ala Ser 
                85                  90                  95      


Thr Ile Glu Leu Trp Lys Asn Glu Lys Asn Lys Val Thr Gln Val Thr 
            100                 105                 110         


Tyr Leu Gln Gln Val Thr Ser Ser Asn Ala Gly Ala Thr Tyr Gln Val 
        115                 120                 125             


Lys Met Thr Gln Val Gly Leu Asn Phe Gly Ser Gln Asn Ala Asn Lys 
    130                 135                 140                 


Lys Val Thr Leu Thr Phe Pro Glu Gly Asp Met Phe Lys Thr Ala Asp 
145                 150                 155                 160 


Thr Ser Leu Ala Gln Ser His Glu Val Lys Leu Asp Gln Asn Gly Thr 
                165                 170                 175     


Ile Thr Leu Pro Glu Val Val Met Asn Val Thr Ala Lys Asp Phe Ala 
            180                 185                 190         


Asn Pro Ala Val Val Asn Trp Tyr Asn Thr Ala Thr Asn Ala Val Val 
        195                 200                 205             


Ser Thr Gly Asn Ile Glu Leu Phe Ala Gly Ser Asp Ala Gly Lys Met 
    210                 215                 220                 


Asn Val Ala Gln Val Val Ser Ala Thr Glu Lys Lys Tyr His Ala Ser 
225                 230                 235                 240 


Asn Tyr Gly Thr Lys Ala Asn Gln Glu Ser Ser Thr Ile Ser Tyr Thr 
                245                 250                 255     


Asn Asn Leu Lys Asp Ala Leu Lys Ala Met Asn Val Asp Val Asp Ala 
            260                 265                 270         


Gln Gly Trp Phe Val Ala Pro Lys Ser Phe Thr Phe Asn Met Thr Ala 
        275                 280                 285             


Lys Ala Asn Asn Asn Asp Ala Ser Ser Thr Leu Ala Val Thr Val Ser 
    290                 295                 300                 


Val Pro Asn Gly Lys Asp Met Thr Val Pro Ser Gln Ser Lys Thr Val 
305                 310                 315                 320 


Met His Asn Ala Phe Phe Tyr Asp Lys Asn Gly Lys Arg Val Gly Ser 
                325                 330                 335     


Asp Lys Val Thr Arg Tyr Asn Ser Ala Thr Val Ala Met Asn Thr Thr 
            340                 345                 350         


Thr Ile Asn Gly Lys Ala Tyr Tyr Glu Val Ile Glu Asn Gly Lys Ala 
        355                 360                 365             


Thr Gly Lys Phe Ile Asn Ala Ala Asn Ile Asp Gly Thr Lys Arg Thr 
    370                 375                 380                 


Leu Lys His Asn Ala Tyr Val Tyr Lys Ser Ser Lys Lys Arg Ala Asn 
385                 390                 395                 400 


Lys Val Val Leu Lys Lys Gly Thr Glu Val Val Thr Tyr Gly Gly Ala 
                405                 410                 415     


Tyr Thr Phe Lys Asn Gly Lys Gln Tyr Tyr Lys Ile Gly Asn Asn Thr 
            420                 425                 430         


Asp Lys Thr Tyr Val Lys Val Ser Asn Phe 
        435                 440         


<210>  53
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SlpA protein sequence

<400>  53

Ser Val Ser Glu Ser Lys Asp Thr Val Asn Val Thr Pro Ser Phe Thr 
1               5                   10                  15      


Leu Thr Ser Ala Ile Pro Ala Lys Gly Val Pro Ala Thr Leu Gln Gly 
            20                  25                  30          


Ser Ile Glu Ala Ser Leu Asn Gly Thr Ser Val Thr Ala Asp Val Ala 
        35                  40                  45              


Asp Val Ala Lys Asp Val Thr Leu Thr Asp Gly Asn Lys Thr Val Tyr 
    50                  55                  60                  


Ser Tyr Asn Glu Arg Glu Asn Lys Val Asp Asn Asn Leu Ser Ala Val 
65                  70                  75                  80  


Glu Ala Ser Lys Glu Tyr Thr Met Thr Leu Ser Gly Val Gly Phe Ser 
                85                  90                  95      


Phe Gly Lys Ala Asn Ala Gly Lys Thr Leu Thr Phe Lys Leu Pro Lys 
            100                 105                 110         


Asn Val Lys Val Asn Asp Thr Ser Asn Asp Val Lys Val Ser Leu Asp 
        115                 120                 125             


Gln Tyr Gly Asn Ala Thr Asn Leu Lys Phe Val Ile Ser Asn Ile Lys 
    130                 135                 140                 


Ala Tyr Asp Ser Ala Asn Thr Asn Ala Val Ser Phe Tyr Ala Ala Lys 
145                 150                 155                 160 


Ser Gly Leu Val Ala Thr Gln Gly Ser Tyr Met Thr Leu Ala Asp Glu 
                165                 170                 175     


Asn Gly Asn Leu Asn Val Asn Thr Leu Leu Asp Lys Leu Lys Gly Lys 
            180                 185                 190         


Tyr Glu Ala Met Gln Phe Lys Asp Ser Lys Phe Glu Thr Val Asn Val 
        195                 200                 205             


Asn Thr Thr Ala Asp Asp Val Lys Ala Glu Leu Glu Lys Ala Gly Ile 
    210                 215                 220                 


Lys Val Asp Ala Ala Asn Asn Phe Glu Ala Pro Asp Thr Phe Thr Val 
225                 230                 235                 240 


Thr Leu Asn Ala Lys Ser Asp Val Asn Gly Lys Thr Ala Ser Leu Pro 
                245                 250                 255     


Val Val Val Thr Val Pro Asn Gly Lys Ser Thr Val Val Pro Ser Gln 
            260                 265                 270         


Ser Lys Thr Ile Met His Asn Ala Tyr Tyr Tyr Asp Lys Asp Ala Lys 
        275                 280                 285             


Arg Val Gly Thr Asp Lys Val Thr Arg Tyr Asn Ala Val Thr Val Ala 
    290                 295                 300                 


Met Asn Thr Thr Lys Leu Ala Asn Gly Ile Ser Tyr Tyr Glu Val Ile 
305                 310                 315                 320 


Glu Asn 
        


<210>  54
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SlpA protein sequence

<400>  54

Ala Asp Ser Ala Ile Asn Ala Asn Thr Asn Ala Lys Tyr Asp Val Asp 
1               5                   10                  15      


Val Thr Pro Ser Ile Ser Ala Ile Ala Ala Val Ala Lys Ser Asp Thr 
            20                  25                  30          


Met Pro Ala Ile Pro Gly Ser Leu Thr Gly Ser Ile Ser Ala Ser Tyr 
        35                  40                  45              


Asn Gly Lys Ser Tyr Thr Ala Asn Leu Pro Lys Asp Ser Gly Asn Ala 
    50                  55                  60                  


Thr Ile Thr Asp Ser Asn Asn Asn Thr Val Lys Pro Ala Lys Leu Glu 
65                  70                  75                  80  


Ala Asp Lys Ala Tyr Thr Val Thr Val Pro Asp Val Ser Phe Asn Phe 
                85                  90                  95      


Gly Ser Glu Asn Ala Gly Lys Val Ile Thr Ile Gly Ser Ala Asn Pro 
            100                 105                 110         


Asn Val Thr Phe Thr Lys Lys Thr Gly Asp Gln Pro Ala Ser Thr Val 
        115                 120                 125             


Lys Val Thr Leu Asp Gln Asp Gly Val Ala Lys Leu Ser Ser Val Gln 
    130                 135                 140                 


Ile Lys Asn Val Tyr Ala Ile Asp Thr Thr Tyr Asn Ser Asn Val Asn 
145                 150                 155                 160 


Phe Tyr Asp Val Thr Thr Gly Ala Ile Val Thr Thr Gly Ala Val Ser 
                165                 170                 175     


Ile Asp Ala Asp Asn Gln Gly Gln Leu Asn Ile Thr Ser Val Val Ala 
            180                 185                 190         


Ala Ile Asn Ser Lys Tyr Phe Ala Ala Gln Tyr Asp Lys Lys Gln Leu 
        195                 200                 205             


Thr Asn Asp Val Thr Phe Asp Thr Glu Thr Ala Val Lys Asp Ala Leu 
    210                 215                 220                 


Lys Ala Gln Lys Ile Glu Val Ser Ser Val Gly Tyr Phe Lys Ala Pro 
225                 230                 235                 240 


His Thr Phe Thr Val Asn Val Lys Ala Thr Ser Asn Lys Asn Gly Lys 
                245                 250                 255     


Ser Ala Thr Leu Pro Val Thr Val Thr Val Pro Asn Val Ala Asp Pro 
            260                 265                 270         


Val Val Pro Ser Gln Ser Lys Thr Ile Met His Asn Ala Tyr Phe Tyr 
        275                 280                 285             


Asp Lys Asp Ala Lys Arg Val Gly Thr Asp Lys Val Thr Arg Tyr Asn 
    290                 295                 300                 


Thr Val Thr Val Ala Met Asn Thr Thr Lys Leu Ala Asn Gly Ile Ser 
305                 310                 315                 320 


Tyr Tyr Glu Val Ile Glu Asn Gly Lys Ala 
                325                 330 


<210>  55
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SlpA protein sequence

<400>  55

Met Asp His Val Ser Lys Gly Phe Val His Tyr Arg Leu Leu Ser His 
1               5                   10                  15      


Ala Glu Pro Met Ala Tyr Tyr Ile Phe Tyr Ile Ser Arg Arg Lys Asp 
            20                  25                  30          


His Met Lys Lys Asn Leu Arg Ile Val Ser Ala Ala Ala Ala Ala Leu 
        35                  40                  45              


Leu Ala Val Ala Pro Val Ala Ala Thr Ala Met Pro Val Asn Ala Ala 
    50                  55                  60                  


Thr Thr Ile Asn Ala Asp Ser Ala Ile Asn Ala Asn Thr Asn Ala Lys 
65                  70                  75                  80  


Tyr Asp Val Asp Val Thr Pro Ser Ile Ser Ala Ile Ala Lys Val Thr 
                85                  90                  95      


Gly Ser Ala Thr Ile Pro Gly Ser Leu Thr Gly Ser Ile Ser Ala Ser 
            100                 105                 110         


Tyr Asn Gly Lys Ser Tyr Thr Ala Asn Leu Pro Lys Asp Ser Gly Asn 
        115                 120                 125             


Ala Thr Ile Ala Asp Lys His Gly Asn Pro Val Lys Pro Ala Asp Leu 
    130                 135                 140                 


Glu Ala Asp Lys Ala Tyr Thr Val Thr Val Pro Asp Val Ser Phe Asn 
145                 150                 155                 160 


Phe Gly Ser Glu Asn Ala Gly Lys Glu Ile Thr Ile Gly Ser Ala Asn 
                165                 170                 175     


Gln Asn Val Thr Phe Thr Thr Lys Asp Ser Gln Ser Gly Ser Thr Val 
            180                 185                 190         


Ser Gly Ser Thr Val Lys Val Thr Leu Asp Gln Asp Gly Val Ala Lys 
        195                 200                 205             


Leu Ser Ser Val Gln Ile Lys Asp Val Tyr Ala Ile Asp Thr Thr Tyr 
    210                 215                 220                 


Asn Ser Asn Val Asn Phe Tyr Asp Val Thr Thr Gly Ala Ile Val Thr 
225                 230                 235                 240 


Thr Gly Ala Val Ser Ile Asp Ala Asp Asn Gln Gly Gln Leu Asn Thr 
                245                 250                 255     


Ala Ser Val Val Ala Ala Ile Ser Ser Lys Tyr Phe Ala Ala Gln Tyr 
            260                 265                 270         


Ala Asp Lys Asn Leu Thr Ser Asp Asn Val Thr Tyr Asn Ile Glu Thr 
        275                 280                 285             


Ala Val Lys Asp Ala Leu Lys Ala Gln Lys Ile Glu Val Ser Ser Val 
    290                 295                 300                 


Gly Tyr Phe Lys Ala Pro His Thr Phe Thr Val Asn Val Lys Ala Thr 
305                 310                 315                 320 


Ser Asn Lys Asn Gly Lys Ser Ala Thr Leu Pro Val Thr Val Thr Val 
                325                 330                 335     


Pro Asn Val Ala Asp Pro Val Val Pro Ser Gln Ser Lys Thr Ile Met 
            340                 345                 350         


His Asn Ala Tyr Phe Tyr Asp Lys Asp Ala Lys Arg Val Gly Thr Asp 
        355                 360                 365             


Lys Val Thr Arg Tyr Asn Thr Val Thr Val Ala Met Asn Thr Thr Lys 
    370                 375                 380                 


Leu Ala Asn Gly Ile Ser Tyr Tyr Glu Val Ile Glu Asn Gly Lys Ala 
385                 390                 395                 400 


Thr Gly Lys Tyr Ile Asn Ala Asp Asn Ile Asp Gly Thr Lys Arg Thr 
                405                 410                 415     


Leu Lys His Asn Ala Tyr Val Tyr Lys Thr Ser Lys Lys Arg Ala Asn 
            420                 425                 430         


Lys Val Val Leu Lys Lys Gly Thr Glu Val Thr Thr Tyr Gly Gly Ser 
        435                 440                 445             


Tyr Lys Phe Lys Asn Gly Lys Lys Tyr Tyr Lys Ile Gly Ala Asp Thr 
    450                 455                 460                 


Lys Lys Thr Tyr Val Arg Val Glu Asn Phe Asp 
465                 470                 475 


