                         SEQUENCE LISTING

<110>  Queen Mary University of London
 
<120>  PEPTIDES

<130>  P56958WO

<150>  GB1418562.3
<151>  2014-10-20

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Arg Ala Trp Ile Leu Leu Thr Leu Gly Leu Val Ala Cys Val 
1               5                   10                  15      


Ser Ala Glu Ser Arg Ala Glu Leu Thr Ser Asp Lys Asp Met Tyr Leu 
            20                  25                  30          


Asp Asn Ser Ser Ile Glu Glu Ala Ser Gly Val Tyr Pro Ile Asp Asp 
        35                  40                  45              


Asp Asp Tyr Ala Ser Ala Ser Gly Ser Gly Ala Asp Glu Asp Val Glu 
    50                  55                  60                  


Ser Pro Glu Leu Thr Thr Ser Arg Pro Leu Pro Lys Ile Leu Leu Thr 
65                  70                  75                  80  


Ser Ala Ala Pro Lys Val Glu Thr Thr Thr Leu Asn Ile Gln Asn Lys 
                85                  90                  95      


Ile Pro Ala Gln Thr Lys Ser Pro Glu Glu Thr Asp Lys Glu Lys Val 
            100                 105                 110         


His Leu Ser Asp Ser Glu Arg Lys Met Asp Pro Ala Glu Glu Asp Thr 
        115                 120                 125             


Asn Val Tyr Thr Glu Lys His Ser Asp Ser Leu Phe Lys Arg Thr Glu 
    130                 135                 140                 


Val Leu Ala Ala Val Ile Ala Gly Gly Val Ile Gly Phe Leu Phe Ala 
145                 150                 155                 160 


Ile Phe Leu Ile Leu Leu Leu Val Tyr Arg Met Arg Lys Lys Asp Glu 
                165                 170                 175     


Gly Ser Tyr Asp Leu Gly Glu Arg Lys Pro Ser Ser Ala Ala Tyr Gln 
            180                 185                 190         


Lys Ala Pro Thr Lys Glu Phe Tyr Ala 
        195                 200     


<210>  2
<211>  202
<212>  PRT
<213>  Mus musculus

<400>  2

Met Gln Arg Ala Trp Ile Leu Leu Thr Leu Gly Leu Met Ala Cys Val 
1               5                   10                  15      


Ser Ala Glu Thr Arg Thr Glu Leu Thr Ser Asp Lys Asp Met Tyr Leu 
            20                  25                  30          


Asp Asn Ser Ser Ile Glu Glu Ala Ser Gly Val Tyr Pro Ile Asp Asp 
        35                  40                  45              


Asp Asp Tyr Ser Ser Ala Ser Gly Ser Gly Ala Asp Glu Asp Ile Glu 
    50                  55                  60                  


Ser Pro Val Leu Thr Thr Ser Gln Leu Ile Pro Arg Ile Pro Leu Thr 
65                  70                  75                  80  


Ser Ala Ala Ser Pro Lys Val Glu Thr Met Thr Leu Lys Thr Gln Ser 
                85                  90                  95      


Ile Thr Pro Ala Gln Thr Glu Ser Pro Glu Glu Thr Asp Lys Glu Glu 
            100                 105                 110         


Val Asp Ile Ser Glu Ala Glu Glu Lys Leu Gly Pro Ala Ile Lys Ser 
        115                 120                 125             


Thr Asp Val Tyr Thr Glu Lys His Ser Asp Asn Leu Phe Lys Arg Thr 
    130                 135                 140                 


Glu Val Leu Ala Ala Val Ile Ala Gly Gly Val Ile Gly Phe Leu Phe 
145                 150                 155                 160 


Ala Ile Phe Leu Ile Leu Leu Leu Val Tyr Arg Met Arg Lys Lys Asp 
                165                 170                 175     


Glu Gly Ser Tyr Asp Leu Gly Glu Arg Lys Pro Ser Ser Ala Ala Tyr 
            180                 185                 190         


Gln Lys Ala Pro Thr Lys Glu Phe Tyr Ala 
        195                 200         


<210>  3
<211>  400
<212>  PRT
<213>  Artificial sequence

<220>
<223>  S2ED


<220>
<221>  GST + Linker
<222>  (1)..(277)

<220>
<221>  18 amino acid peptide
<222>  (383)..(400)


<400>  3

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Gly Ser Thr Ser 
    210                 215                 220                 


Gly Ser Gly His His His His His His Ser Ala Gly Leu Val Pro Arg 
225                 230                 235                 240 


Gly Ser Thr Ala Ile Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu 
                245                 250                 255     


Arg Gln His Met Asp Ser Pro Asp Leu Gly Thr Gly Gly Gly Ser Gly 
            260                 265                 270         


Asp Asp Asp Asp Lys Glu Thr Arg Thr Glu Leu Thr Ser Asp Lys Asp 
        275                 280                 285             


Met Tyr Leu Asp Asn Ser Ser Ile Glu Glu Ala Ser Gly Val Tyr Pro 
    290                 295                 300                 


Ile Asp Asp Asp Asp Tyr Ser Ser Ala Ser Gly Ser Gly Ala Asp Glu 
305                 310                 315                 320 


Asp Ile Glu Ser Pro Val Leu Thr Thr Ser Gln Leu Ile Pro Arg Ile 
                325                 330                 335     


Pro Leu Thr Ser Ala Ala Ser Pro Lys Val Glu Thr Met Thr Leu Lys 
            340                 345                 350         


Thr Gln Ser Ile Thr Pro Ala Gln Thr Glu Ser Pro Glu Glu Thr Asp 
        355                 360                 365             


Lys Glu Glu Val Asp Ile Ser Glu Ala Glu Glu Lys Leu Gly Pro Ala 
    370                 375                 380                 


Ile Lys Ser Thr Asp Val Tyr Thr Glu Lys His Ser Asp Asn Leu Phe 
385                 390                 395                 400 


<210>  4
<211>  382
<212>  PRT
<213>  Artificial sequence

<220>
<223>  S2EDdeltaP124-F141


<220>
<221>  GST + Linker
<222>  (1)..(277)

<400>  4

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Gly Ser Thr Ser 
    210                 215                 220                 


Gly Ser Gly His His His His His His Ser Ala Gly Leu Val Pro Arg 
225                 230                 235                 240 


Gly Ser Thr Ala Ile Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu 
                245                 250                 255     


Arg Gln His Met Asp Ser Pro Asp Leu Gly Thr Gly Gly Gly Ser Gly 
            260                 265                 270         


Asp Asp Asp Asp Lys Glu Thr Arg Thr Glu Leu Thr Ser Asp Lys Asp 
        275                 280                 285             


Met Tyr Leu Asp Asn Ser Ser Ile Glu Glu Ala Ser Gly Val Tyr Pro 
    290                 295                 300                 


Ile Asp Asp Asp Asp Tyr Ser Ser Ala Ser Gly Ser Gly Ala Asp Glu 
305                 310                 315                 320 


Asp Ile Glu Ser Pro Val Leu Thr Thr Ser Gln Leu Ile Pro Arg Ile 
                325                 330                 335     


Pro Leu Thr Ser Ala Ala Ser Pro Lys Val Glu Thr Met Thr Leu Lys 
            340                 345                 350         


Thr Gln Ser Ile Thr Pro Ala Gln Thr Glu Ser Pro Glu Glu Thr Asp 
        355                 360                 365             


Lys Glu Glu Val Asp Ile Ser Glu Ala Glu Glu Lys Leu Gly 
    370                 375                 380         


<210>  5
<211>  349
<212>  PRT
<213>  Artificial sequence

<220>
<223>  S2EDdeltaL73-G123


<220>
<221>  GST + Linker
<222>  (1)..(277)

<220>
<221>  18 amino acid peptide
<222>  (332)..(349)


<400>  5

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Gly Ser Thr Ser 
    210                 215                 220                 


Gly Ser Gly His His His His His His Ser Ala Gly Leu Val Pro Arg 
225                 230                 235                 240 


Gly Ser Thr Ala Ile Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu 
                245                 250                 255     


Arg Gln His Met Asp Ser Pro Asp Leu Gly Thr Gly Gly Gly Ser Gly 
            260                 265                 270         


Asp Asp Asp Asp Lys Glu Thr Arg Thr Glu Leu Thr Ser Asp Lys Asp 
        275                 280                 285             


Met Tyr Leu Asp Asn Ser Ser Ile Glu Glu Ala Ser Gly Val Tyr Pro 
    290                 295                 300                 


Ile Asp Asp Asp Asp Tyr Ser Ser Ala Ser Gly Ser Gly Ala Asp Glu 
305                 310                 315                 320 


Asp Ile Glu Ser Pro Val Leu Thr Thr Ser Gln Pro Ala Ile Lys Ser 
                325                 330                 335     


Thr Asp Val Tyr Thr Glu Lys His Ser Asp Asn Leu Phe 
            340                 345                 


<210>  6
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  hS2pep peptide derived from human syndecan-2

<400>  6

Pro Ala Glu Glu Asp Thr Asn Val Tyr Thr Glu Lys His Ser Asp Ser 
1               5                   10                  15      


Leu Phe 
        


<210>  7
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Scrambled peptide used as a negative control

<400>  7

Val Pro Tyr Phe Asn Ala Thr Leu Thr Asp Glu Glu Ser Ser Asp Lys 
1               5                   10                  15      


Glu Thr 
        


<210>  8
<211>  606
<212>  DNA
<213>  Homo sapiens

<400>  8
atgcggcgcg cgtggatcct gctcaccttg ggcttggtgg cctgcgtgtc ggcggagtcg       60

agagcagagc tgacatctga taaagacatg taccttgaca acagctccat tgaagaagct      120

tcaggagtgt atcctattga tgacgatgac tacgcttctg cgtctggctc gggagctgat      180

gaggatgtag agagtccaga gctgacaaca tctcgaccac ttccaaagat actgttgact      240

agtgctgctc caaaagtgga aaccacgacg ctgaatatac agaacaagat acctgctcag      300

acaaagtcac ctgaagaaac tgataaagag aaagttcacc tctctgactc agaaaggaaa      360

atggacccag ccgaagagga tacaaatgtg tatactgaga aacactcaga cagtctgttt      420

aaacggacag aagtcctagc agctgtcatt gctggtggag ttattggctt tctctttgca      480

atttttctta tcctgctgtt ggtgtatcgc atgagaaaga aggatgaagg aagctatgac      540

cttggagaac gcaaaccatc cagtgctgct tatcagaagg cacctactaa ggagttttat      600

gcgtaa                                                                 606


<210>  9
<211>  609
<212>  DNA
<213>  Mus musculus

<400>  9
atgcagcgcg cgtggatcct gctcaccttg ggcttgatgg cctgtgtgtc cgcagagacg       60

agaacagagc tgacatccga taaggatatg taccttgaca atagctccat tgaggaagct      120

tcaggagtat atcctattga tgatgatgac tattcttctg cctcaggctc aggagctgat      180

gaagacatag agagtccagt tctgacaaca tcccaactga ttccaagaat cccactcact      240

agtgctgctt cccccaaagt ggaaaccatg acgttgaaga cacaaagcat tacacctgct      300

cagactgagt cacctgaaga aactgacaag gaggaagttg acatttctga ggcagaagag      360

aagctgggcc ctgctataaa aagcacagat gtgtacacgg agaaacattc agacaatctg      420

tttaaacgga cagaagttct agcagccgtc attgctggtg gtgtgatcgg ctttctcttt      480

gccattttcc tcatcctgct attggtgtac cgcatgcgga agaaagatga aggaagctac      540

gaccttggag aacgcaaacc atccagcgca gcttaccaga aggcacccac taaggagttt      600

tatgcataa                                                              609


<210>  10
<211>  1050
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA sequence of S2ED peptide used in the Examples

<400>  10
atgtccccta tactaggtta ttggaaaatt aagggccttg tgcaacccac tcgacttctt       60

ttggaatatc ttgaagaaaa atatgaagag catttgtatg agcgcgatga aggtgataaa      120

tggcgaaaca aaaagtttga attgggtttg gagtttccca atcttcctta ttatattgat      180

ggtgatgtta aattaacaca gtctatggcc atcatacgtt atatagctga caagcacaac      240

atgttgggtg gttgtccaaa agagcgtgca gagatttcaa tgcttgaagg agcggttttg      300

gatattagat acggtgtttc gagaattgca tatagtaaag actttgaaac tctcaaagtt      360

gattttctta gcaagctacc tgaaatgctg aaaatgttcg aagatcgttt atgtcataaa      420

acatatttaa atggtgatca tgtaacccat cctgacttca tgttgtatga cgctcttgat      480

gttgttttat acatggaccc aatgtgcctg gatgcgttcc caaaattagt ttgttttaaa      540

aaacgtattg aagctatccc acaaattgat aagtacttga aatccagcaa gtatatagca      600

tggcctttgc agggctggca agccacgttt ggtggtggcg accatcctcc aaaatcggat      660

ggttcaacta gtggttctgg tcatcaccat caccatcact ccgcgggtct ggtgccacgc      720

ggtagtactg caattggtat gaaagaaacc gctgctgcta aattcgaacg ccagcacatg      780

gacagcccag atctgggtac cggtggtggc tccggtgatg acgacgacaa ggagacgaga      840

acagagctga catccgataa ggatatgtac cttgacaata gctccattga ggaagcttca      900

ggagtatatc ctattgatga tgatgactat tcttctgcct caggctcagg agctgatgaa      960

gacatagaga gtccagttct gacaacatcc caacctgcta taaaaagcac agatgtgtac     1020

acggagaaac attcagacaa tctgttttaa                                      1050


<210>  11
<211>  1149
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA sequence of S2EDdeltaP124-F141 peptide used in the Examples

<400>  11
atgtccccta tactaggtta ttggaaaatt aagggccttg tgcaacccac tcgacttctt       60

ttggaatatc ttgaagaaaa atatgaagag catttgtatg agcgcgatga aggtgataaa      120

tggcgaaaca aaaagtttga attgggtttg gagtttccca atcttcctta ttatattgat      180

ggtgatgtta aattaacaca gtctatggcc atcatacgtt atatagctga caagcacaac      240

atgttgggtg gttgtccaaa agagcgtgca gagatttcaa tgcttgaagg agcggttttg      300

gatattagat acggtgtttc gagaattgca tatagtaaag actttgaaac tctcaaagtt      360

gattttctta gcaagctacc tgaaatgctg aaaatgttcg aagatcgttt atgtcataaa      420

acatatttaa atggtgatca tgtaacccat cctgacttca tgttgtatga cgctcttgat      480

gttgttttat acatggaccc aatgtgcctg gatgcgttcc caaaattagt ttgttttaaa      540

aaacgtattg aagctatccc acaaattgat aagtacttga aatccagcaa gtatatagca      600

tggcctttgc agggctggca agccacgttt ggtggtggcg accatcctcc aaaatcggat      660

ggttcaacta gtggttctgg tcatcaccat caccatcact ccgcgggtct ggtgccacgc      720

ggtagtactg caattggtat gaaagaaacc gctgctgcta aattcgaacg ccagcacatg      780

gacagcccag atctgggtac cggtggtggc tccggtgatg acgacgacaa ggagacgaga      840

acagagctga catccgataa ggatatgtac cttgacaata gctccattga ggaagcttca      900

ggagtatatc ctattgatga tgatgactat tcttctgcct caggctcagg agctgatgaa      960

gacatagaga gtccagttct gacaacatcc caactgattc caagaatccc actcactagt     1020

gctgcttccc ccaaagtgga aaccatgacg ttgaagacac aaagcattac acctgctcag     1080

actgagtcac ctgaagaaac tgacaaggag gaagttgaca tttctgaggc agaagagaag     1140

ctgggctaa                                                             1149


<210>  12
<211>  1050
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA sequence of S2EDdeltaL73-G123 peptide used in the Examples

<400>  12
atgtccccta tactaggtta ttggaaaatt aagggccttg tgcaacccac tcgacttctt       60

ttggaatatc ttgaagaaaa atatgaagag catttgtatg agcgcgatga aggtgataaa      120

tggcgaaaca aaaagtttga attgggtttg gagtttccca atcttcctta ttatattgat      180

ggtgatgtta aattaacaca gtctatggcc atcatacgtt atatagctga caagcacaac      240

atgttgggtg gttgtccaaa agagcgtgca gagatttcaa tgcttgaagg agcggttttg      300

gatattagat acggtgtttc gagaattgca tatagtaaag actttgaaac tctcaaagtt      360

gattttctta gcaagctacc tgaaatgctg aaaatgttcg aagatcgttt atgtcataaa      420

acatatttaa atggtgatca tgtaacccat cctgacttca tgttgtatga cgctcttgat      480

gttgttttat acatggaccc aatgtgcctg gatgcgttcc caaaattagt ttgttttaaa      540

aaacgtattg aagctatccc acaaattgat aagtacttga aatccagcaa gtatatagca      600

tggcctttgc agggctggca agccacgttt ggtggtggcg accatcctcc aaaatcggat      660

ggttcaacta gtggttctgg tcatcaccat caccatcact ccgcgggtct ggtgccacgc      720

ggtagtactg caattggtat gaaagaaacc gctgctgcta aattcgaacg ccagcacatg      780

gacagcccag atctgggtac cggtggtggc tccggtgatg acgacgacaa ggagacgaga      840

acagagctga catccgataa ggatatgtac cttgacaata gctccattga ggaagcttca      900

ggagtatatc ctattgatga tgatgactat tcttctgcct caggctcagg agctgatgaa      960

gacatagaga gtccagttct gacaacatcc caacctgcta taaaaagcac agatgtgtac     1020

acggagaaac attcagacaa tctgttttaa                                      1050


