                         SEQUENCE LISTING


<110>  AstraZeneca AB
 
<120>  COMBINATION

<130>  200252-WO-PCT

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  4978
<212>  DNA
<213>  Homo sapiens

<400>  1
ggtttccgga gctgcggcgg cgcagactgg gagggggagc cgggggttcc gacgtcgcag       60

ccgagggaac aagccccaac cggatcctgg acaggcaccc cggcttggcg ctgtctctcc      120

ccctcggctc ggagaggccc ttcggcctga gggagcctcg ccgcccgtcc ccggcacacg      180

cgcagccccg gcctctcggc ctctgccgga gaaacagttg ggacccctga ttttagcagg      240

atggcccaat ggaatcagct acagcagctt gacacacggt acctggagca gctccatcag      300

ctctacagtg acagcttccc aatggagctg cggcagtttc tggccccttg gattgagagt      360

caagattggg catatgcggc cagcaaagaa tcacatgcca ctttggtgtt tcataatctc      420

ctgggagaga ttgaccagca gtatagccgc ttcctgcaag agtcgaatgt tctctatcag      480

cacaatctac gaagaatcaa gcagtttctt cagagcaggt atcttgagaa gccaatggag      540

attgcccgga ttgtggcccg gtgcctgtgg gaagaatcac gccttctaca gactgcagcc      600

actgcggccc agcaaggggg ccaggccaac caccccacag cagccgtggt gacggagaag      660

cagcagatgc tggagcagca ccttcaggat gtccggaaga gagtgcagga tctagaacag      720

aaaatgaaag tggtagagaa tctccaggat gactttgatt tcaactataa aaccctcaag      780

agtcaaggag acatgcaaga tctgaatgga aacaaccagt cagtgaccag gcagaagatg      840

cagcagctgg aacagatgct cactgcgctg gaccagatgc ggagaagcat cgtgagtgag      900

ctggcggggc ttttgtcagc gatggagtac gtgcagaaaa ctctcacgga cgaggagctg      960

gctgactgga agaggcggca acagattgcc tgcattggag gcccgcccaa catctgccta     1020

gatcggctag aaaactggat aacgtcatta gcagaatctc aacttcagac ccgtcaacaa     1080

attaagaaac tggaggagtt gcagcaaaaa gtttcctaca aaggggaccc cattgtacag     1140

caccggccga tgctggagga gagaatcgtg gagctgttta gaaacttaat gaaaagtgcc     1200

tttgtggtgg agcggcagcc ctgcatgccc atgcatcctg accggcccct cgtcatcaag     1260

accggcgtcc agttcactac taaagtcagg ttgctggtca aattccctga gttgaattat     1320

cagcttaaaa ttaaagtgtg cattgacaaa gactctgggg acgttgcagc tctcagagga     1380

tcccggaaat ttaacattct gggcacaaac acaaaagtga tgaacatgga agaatccaac     1440

aacggcagcc tctctgcaga attcaaacac ttgaccctga gggagcagag atgtgggaat     1500

gggggccgag ccaattgtga tgcttccctg attgtgactg aggagctgca cctgatcacc     1560

tttgagaccg aggtgtatca ccaaggcctc aagattgacc tagagaccca ctccttgcca     1620

gttgtggtga tctccaacat ctgtcagatg ccaaatgcct gggcgtccat cctgtggtac     1680

aacatgctga ccaacaatcc caagaatgta aactttttta ccaagccccc aattggaacc     1740

tgggatcaag tggccgaggt cctgagctgg cagttctcct ccaccaccaa gcgaggactg     1800

agcatcgagc agctgactac actggcagag aaactcttgg gacctggtgt gaattattca     1860

gggtgtcaga tcacatgggc taaattttgc aaagaaaaca tggctggcaa gggcttctcc     1920

ttctgggtct ggctggacaa tatcattgac cttgtgaaaa agtacatcct ggccctttgg     1980

aacgaagggt acatcatggg ctttatcagt aaggagcggg agcgggccat cttgagcact     2040

aagcctccag gcaccttcct gctaagattc agtgaaagca gcaaagaagg aggcgtcact     2100

ttcacttggg tggagaagga catcagcggt aagacccaga tccagtccgt ggaaccatac     2160

acaaagcagc agctgaacaa catgtcattt gctgaaatca tcatgggcta taagatcatg     2220

gatgctacca atatcctggt gtctccactg gtctatctct atcctgacat tcccaaggag     2280

gaggcattcg gaaagtattg tcggccagag agccaggagc atcctgaagc tgacccaggt     2340

agcgctgccc catacctgaa gaccaagttt atctgtgtga caccaacgac ctgcagcaat     2400

accattgacc tgccgatgtc cccccgcact ttagattcat tgatgcagtt tggaaataat     2460

ggtgaaggtg ctgaaccctc agcaggaggg cagtttgagt ccctcacctt tgacatggag     2520

ttgacctcgg agtgcgctac ctcccccatg tgaggagctg agaacggaag ctgcagaaag     2580

atacgactga ggcgcctacc tgcattctgc cacccctcac acagccaaac cccagatcat     2640

ctgaaactac taactttgtg gttccagatt ttttttaatc tcctacttct gctatctttg     2700

agcaatctgg gcacttttaa aaatagagaa atgagtgaat gtgggtgatc tgcttttatc     2760

taaatgcaaa taaggatgtg ttctctgaga cccatgatca ggggatgtgg cggggggtgg     2820

ctagagggag aaaaaggaaa tgtcttgtgt tgttttgttc ccctgccctc ctttctcagc     2880

agctttttgt tattgttgtt gttgttctta gacaagtgcc tcctggtgcc tgcggcatcc     2940

ttctgcctgt ttctgtaagc aaatgccaca ggccacctat agctacatac tcctggcatt     3000

gcacttttta accttgctga catccaaata gaagatagga ctatctaagc cctaggtttc     3060

tttttaaatt aagaaataat aacaattaaa gggcaaaaaa cactgtatca gcatagcctt     3120

tctgtattta agaaacttaa gcagccgggc atggtggctc acgcctgtaa tcccagcact     3180

ttgggaggcc gaggcggatc ataaggtcag gagatcaaga ccatcctggc taacacggtg     3240

aaaccccgtc tctactaaaa gtacaaaaaa ttagctgggt gtggtggtgg gcgcctgtag     3300

tcccagctac tcgggaggct gaggcaggag aatcgcttga acctgagagg cggaggttgc     3360

agtgagccaa aattgcacca ctgcacactg cactccatcc tgggcgacag tctgagactc     3420

tgtctcaaaa aaaaaaaaaa aaaaaagaaa cttcagttaa cagcctcctt ggtgctttaa     3480

gcattcagct tccttcaggc tggtaattta tataatccct gaaacgggct tcaggtcaaa     3540

cccttaagac atctgaagct gcaacctggc ctttggtgtt gaaataggaa ggtttaagga     3600

gaatctaagc attttagact tttttttata aatagactta ttttcctttg taatgtattg     3660

gccttttagt gagtaaggct gggcagaggg tgcttacaac cttgactccc tttctccctg     3720

gacttgatct gctgtttcag aggctaggtt gtttctgtgg gtgccttatc agggctggga     3780

tacttctgat tctggcttcc ttcctgcccc accctcccga ccccagtccc cctgatcctg     3840

ctagaggcat gtctccttgc gtgtctaaag gtccctcatc ctgtttgttt taggaatcct     3900

ggtctcagga cctcatggaa gaagaggggg agagagttac aggttggaca tgatgcacac     3960

tatggggccc cagcgacgtg tctggttgag ctcagggaat atggttctta gccagtttct     4020

tggtgatatc cagtggcact tgtaatggcg tcttcattca gttcatgcag ggcaaaggct     4080

tactgataaa cttgagtctg ccctcgtatg agggtgtata cctggcctcc ctctgaggct     4140

ggtgactcct ccctgctggg gccccacagg tgaggcagaa cagctagagg gcctccccgc     4200

ctgcccgcct tggctggcta gctcgcctct cctgtgcgta tgggaacacc tagcacgtgc     4260

tggatgggct gcctctgact cagaggcatg gccggatttg gcaactcaaa accaccttgc     4320

ctcagctgat cagagtttct gtggaattct gtttgttaaa tcaaattagc tggtctctga     4380

attaaggggg agacgacctt ctctaagatg aacagggttc gccccagtcc tcctgcctgg     4440

agacagttga tgtgtcatgc agagctctta cttctccagc aacactcttc agtacataat     4500

aagcttaact gataaacaga atatttagaa aggtgagact tgggcttacc attgggttta     4560

aatcataggg acctagggcg agggttcagg gcttctctgg agcagatatt gtcaagttca     4620

tggccttagg tagcatgtat ctggtcttaa ctctgattgt agcaaaagtt ctgagaggag     4680

ctgagccctg ttgtggccca ttaaagaaca gggtcctcag gccctgcccg cttcctgtcc     4740

actgccccct ccccatcccc agcccagccg agggaatccc gtgggttgct tacctaccta     4800

taaggtggtt tataagctgc tgtcctggcc actgcattca aattccaatg tgtacttcat     4860

agtgtaaaaa tttatattat tgtgaggttt tttgtctttt tttttttttt ttttttttgg     4920

tatattgctg tatctacttt aacttccaga aataaacgtt atataggaac cgtaaaaa       4978


<210>  2
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide (AZD9150)

<400>  2
ctatttggat gtcagc                                                       16



<210>  3
<211>  108
<212>  PRT
<213>  Homo sapiens
<223>  MEDI4736 VL; Sequence 77 from PCT/US2010/058007

<400>  3

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Arg Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Leu Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  4
<211>  121
<212>  PRT
<213>  Homo sapiens
<223>  MEDI4736 VH; Sequence 72 from PCT/US2010/058007

<400>  4

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Gly Trp Phe Gly Glu Leu Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  5
<211>  5
<212>  PRT
<213>  Homo sapiens
<223>  MEDI4736 VH CDR1; Sequence 73 from PCT/US2010/058007

<400>  5

Arg Tyr Trp Met Ser 
1               5   


<210>  6
<211>  17
<212>  PRT
<213>  Homo sapiens
<223>  MEDI4736 VH CDR2;Sequence 74 from PCT/US2010/058007

<400>  6

Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    

<210>  7
<211>  12
<212>  PRT
<213>  Homo sapiens
<223>  MEDI4736 VH CDR3;Sequence 75 from PCT/US2010/058007

<400>  7

Glu Gly Gly Trp Phe Gly Glu Leu Ala Phe Asp Tyr 
1               5                   10          

     

<210>  8
<211>  12
<212>  PRT
<213>  Homo sapiens
<223>  MEDI4736 VL CDR1;Sequence 78 from PCT/US2010/058007

<400>  8

Arg Ala Ser Gln Arg Val Ser Ser Ser Tyr Leu Ala 
1               5                   10     



<210>  9
<211>  7
<212>  PRT
<213>  Homo sapiens
<223>  MEDI4736 VL CDR2;Sequence 79 from PCT/US2010/058007

<400>  9

Asp Ala Ser Ser Arg Ala Thr 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Homo sapiens
<223>  MEDI4736 VL CDR3;Sequence 80 from PCT/US2010/058007

<400>  10

Gln Gln Tyr Gly Ser Leu Pro Trp Thr 
1               5                   


<210>  11
<211>  16
<212>  DNA
<213>  Artificial sequence
<223>  Synthetic oligonucleotide (murine STAT3 ASO)

<400>  11
gaaattcatt cttcca                                                       16


<210>  12
<211>  16
<212>  DNA
<213>  Artificial sequence
<223>  Synthetic oligonucleotide (murine control ASO)

<400>  12
ggctactacg ccgtca                                                       16


<210>  13
<211>  139
<212>  PRT
<213>  Homo sapiens
<223>  Tremelimumab VL

<400>  13

Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
1               5                   10                  15      


Arg Ala Ser Gln Ser Ile Asn Ser Tyr Leu Asp Trp Tyr Gln Gln Lys 
            20                  25                  30          


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
        35                  40                  45              


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    50                  55                  60                  


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
65                  70                  75                  80  


Cys Gln Gln Tyr Tyr Ser Thr Pro Phe Thr Phe Gly Pro Gly Thr Lys 
                85                  90                  95      


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
            100                 105                 110         


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
        115                 120                 125             


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
    130                 135                 


<210>  14
<211>  167
<212>  PRT
<213>  Homo sapiens
<223>  Tremelimumab VH

<400>  14

Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser 
1               5                   10                  15      


Gly Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro 
            20                  25                  30          


Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn 
        35                  40                  45              


Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    50                  55                  60                  


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
65                  70                  75                  80  


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Pro Arg Gly Ala Thr Leu 
                85                  90                  95      


Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His 
                165         


<210>  15
<211>  10
<212>  PRT
<213>  Homo sapiens
<223>  Tremelimumab VH CDR1

<400>  15

Gly Phe Thr Phe Ser Ser Tyr Gly Met His 
1               5                   10  


<210>  16
<211>  15
<212>  PRT
<213>  Homo sapiens
<223>  Tremelimumab VH CDR2


<400>  16

Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  17
<211>  16
<212>  PRT
<213>  Homo sapiens
<223>  Tremelimumab VH CDR3

<400>  17

Asp Pro Arg Gly Ala Thr Leu Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


<210>  18
<211>  11
<212>  PRT
<213>  Homo sapiens
<223>  Tremelimumab VL CDR1

<400>  18

Arg Ala Ser Gln Ser Ile Asn Ser Tyr Leu Asp 
1               5                   10      


<210>  19
<211>  7
<212>  PRT
<213>  Homo sapiens
<223>  Tremelimumab VL CDR2

<400>  19

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  20
<211>  9
<212>  PRT
<213>  Homo sapiens
<223>  Tremelimumab VL CDR3

<400>  20

Gln Gln Tyr Tyr Ser Thr Pro Phe Thr 
1               5                   


<210>  21
<211>  223
<212>  PRT
<213>  Homo sapiens
<223>  CTLA-4 polypeptide - GenBank Accession No. AAL07473.1

<400>  21

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe 
                165                 170                 175     


Tyr Ser Phe Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys 
            180                 185                 190         


Arg Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu 
        195                 200                 205             


Pro Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
    210                 215                 220             


<210>  22
<211>  277
<212>  PRT
<213>  Homo sapiens
<223>  OX40 polypeptide

<400>  22

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
225                 230                 235                 240 


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                245                 250                 255     


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         


Thr Leu Ala Lys Ile 
        275         


<210>  23
<211>  183
<212>  PRT
<213>  Homo sapiens
<223>  OX40 ligand

<400>  23

Met Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly Asn Ala Ala Arg 
1               5                   10                  15      


Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu Val Ala Ser Val Ile Gln 
            20                  25                  30          


Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser 
        35                  40                  45              


Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val 
    50                  55                  60                  


Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln 
65                  70                  75                  80  


Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn 
                85                  90                  95      


Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu 
            100                 105                 110         


Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln 
        115                 120                 125             


Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr 
    130                 135                 140                 


Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu 
145                 150                 155                 160 


Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn 
                165                 170                 175     


Pro Gly Glu Phe Cys Val Leu 
            180             


<210>  24
<211>  410
<212>  PRT
<213>  Artificial sequence
<223>  OX40 ligand protein; corresponds to SEQ ID NO: 8 in U.S. Patent 
       7,959,925

<400>  24

Leu Ala Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
1               5                   10                  15      


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            20                  25                  30          


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        35                  40                  45              


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    50                  55                  60                  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
65                  70                  75                  80  


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                85                  90                  95      


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            100                 105                 110         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        115                 120                 125             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    130                 135                 140                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
145                 150                 155                 160 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                165                 170                 175     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            180                 185                 190         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        195                 200                 205             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    210                 215                 220                 


Ser Leu Ser Pro Gly Lys Glu Leu Leu Gly Gly Gly Ser Ile Lys Gln 
225                 230                 235                 240 


Ile Glu Asp Lys Ile Glu Glu Ile Leu Ser Lys Ile Tyr His Ile Glu 
                245                 250                 255     


Asn Glu Ile Ala Arg Ile Lys Lys Leu Ile Gly Glu Arg Gly His Gly 
            260                 265                 270         


Gly Gly Ser Asn Ser Gln Val Ser His Arg Tyr Pro Arg Phe Gln Ser 
        275                 280                 285             


Ile Lys Val Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu 
    290                 295                 300                 


Thr Ser Gln Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val 
305                 310                 315                 320 


Ile Ile Asn Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe 
                325                 330                 335     


Ser Gln Glu Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro 
            340                 345                 350         


Leu Phe Gln Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val Ala 
        355                 360                 365             


Ser Leu Thr Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn 
    370                 375                 380                 


Thr Ser Leu Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile 
385                 390                 395                 400 


His Gln Asn Pro Gly Glu Phe Cys Val Leu 
                405                 410 


<210>  25
<211>  107
<212>  PRT
<213>  Homo sapiens
<223>  humanised anti-OX40 antibody VL
<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Lys Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Ser Ala Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  26
<211>  107
<212>  PRT
<213>  Homo sapiens
<223>  humanised anti-OX40 antibody VL
<400>  26

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Lys Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Arg Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Ser Ala Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  27
<211>  121
<212>  PRT
<213>  Homo sapiens
<223>  humanised anti-OX40 antibody VH
<400>  27

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys His Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Asn Gly Ile Thr Tyr His Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Asn Arg Asp Thr Ser Lys Asn Gln Tyr Ser Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Lys Tyr Asp Tyr Asp Gly Gly His Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  28
<211>  451
<212>  PRT
<213>  Homo sapiens
<223>  humanised anti-Ox40 antibody heavy chain

<400>  28

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys His Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Asn Gly Ile Thr Tyr His Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Asn Arg Asp Thr Ser Lys Asn Gln Tyr Ser Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Lys Tyr Asp Tyr Asp Gly Gly His Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  29
<211>  214
<212>  PRT
<213>  Homo sapiens
<223>  humanised anti-OX40 antibody Light chain

<400>  29

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Lys Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Ser Ala Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  30
<211>  412
<212>  PRT
<213>  Homo sapiens
<223>  humanised anti-OX40 antibody

<400>  30

Ala Pro Leu Ala Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Glu Leu Leu Gly Gly Gly Ser Ile 
225                 230                 235                 240 


Lys Gln Ile Glu Asp Lys Ile Glu Glu Ile Leu Ser Lys Ile Tyr His 
                245                 250                 255     


Ile Glu Asn Glu Ile Ala Arg Ile Lys Lys Leu Ile Gly Glu Arg Gly 
            260                 265                 270         


His Gly Gly Gly Ser Asn Ser Gln Val Ser His Arg Tyr Pro Arg Phe 
        275                 280                 285             


Gln Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe 
    290                 295                 300                 


Ile Leu Thr Ser Gln Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn 
305                 310                 315                 320 


Ser Val Ile Ile Asn Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly 
                325                 330                 335     


Tyr Phe Ser Gln Glu Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu 
            340                 345                 350         


Glu Pro Leu Phe Gln Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met 
        355                 360                 365             


Val Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr 
    370                 375                 380                 


Asp Asn Thr Ser Leu Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile 
385                 390                 395                 400 


Leu Ile His Gln Asn Pro Gly Glu Phe Cys Val Leu 
                405                 410         



<210>  31
<211>  1206
<212>  DNA
<213>  Homo sapiens
<223>  DNA Sequence of huIgG4FcPTF2OX40L (5 to 3 Open Reading Frame)

<400>  31
gagagcaagt acggccctcc ctgcccccct tgccctgccc ccgagttcct gggcggacct       60

agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagcag aacccccgag      120

gtgacctgcg tggtggtgga cgtgtcccag gaggaccccg aggtccagtt taattggtac      180

gtggacggcg tggaagtgca taacgccaag accaagccca gagaggagca gttcaacagc      240

acctacagag tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggaa      300

tacaagtgca aggtctccaa caagggcctg cctagcagca tcgagaagac catcagcaag      360

gccaagggcc agccacggga gccccaggtc tacaccctgc cacctagcca agaggagatg      420

accaagaacc aggtgtccct gacctgtctg gtgaaaggct tctatcccag cgatatcgcc      480

gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg      540

gacagcgacg gcagcttctt cctgtactcc agactgaccg tggacaagtc cagatggcag      600

gagggcaacg tcttcagctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag      660

aagtccctga gcctgagcct gggcaaggac caggataaga tcgaggctct gtcctccaag      720

gtgcagcagc tggaacggtc catcggcctg aaggacctgg ccatggctga cctggaacag      780

aaagtgctgg aaatggaagc ctccacacag gtgtcacaca gatacccccg gatccagtcc      840

attaaggtgc agttcaccga gtacaagaaa gagaagggct ttatcctgac ctcccagaaa      900

gaggacgaga tcatgaaggt gcagaacaac tccgtgatca tcaactgcga cgggttctac      960

ctgatctccc tgaagggcta cttcagccag gaagtgaaca tctccctgca ctaccagaag     1020

gacgaggaac ccctgttcca gctgaagaaa gtgcggagcg tgaactccct gatggtggcc     1080

tctctgacct acaaggacaa ggtgtacctg aacgtgacca ccgacaacac ctccctggac     1140

gacttccacg tgaacggcgg cgagctgatc ctgatccacc agaaccctgg cgagttctgc     1200

gtgctg                                                                1206


<210>  32
<211>  402
<212>  PRT
<213>  Homo Sapiens
<223>  Amino Acid Sequence of huIgG4FcPTF2OX40L (N to C terminus)

<400>  32

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys Asp Gln Asp Lys Ile Glu Ala Leu Ser Ser Lys 
225                 230                 235                 240 


Val Gln Gln Leu Glu Arg Ser Ile Gly Leu Lys Asp Leu Ala Met Ala 
                245                 250                 255     


Asp Leu Glu Gln Lys Val Leu Glu Met Glu Ala Ser Thr Gln Val Ser 
            260                 265                 270         


His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe Thr Glu Tyr 
        275                 280                 285             


Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp Glu Ile 
    290                 295                 300                 


Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp Gly Phe Tyr 
305                 310                 315                 320 


Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile Ser Leu 
                325                 330                 335     


His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys Val Arg 
            340                 345                 350         


Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp Lys Val 
        355                 360                 365             


Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe His Val 
    370                 375                 380                 


Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly Glu Phe Cys 
385                 390                 395                 400 


Val Leu 
        


<210>  33
<211>  1206
<212>  DNA
<213>  Homo sapiens
<223>  DNA Sequence of huIgG4FcPTF2OX40L F180A (5 to 3 Open Reading Frame)

<400>  33
gagagcaagt acggccctcc ctgcccccct tgccctgccc ccgagttcct gggcggacct       60

agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagcag aacccccgag      120

gtgacctgcg tggtggtgga cgtgtcccag gaggaccccg aggtccagtt taattggtac      180

gtggacggcg tggaagtgca taacgccaag accaagccca gagaggagca gttcaacagc      240

acctacagag tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggaa      300

tacaagtgca aggtctccaa caagggcctg cctagcagca tcgagaagac catcagcaag      360

gccaagggcc agccacggga gccccaggtc tacaccctgc cacctagcca agaggagatg      420

accaagaacc aggtgtccct gacctgtctg gtgaaaggct tctatcccag cgatatcgcc      480

gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg      540

gacagcgacg gcagcttctt cctgtactcc agactgaccg tggacaagtc cagatggcag      600

gagggcaacg tcttcagctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag      660

aagtccctga gcctgagcct gggcaaggac caggataaga tcgaggctct gtcctccaag      720

gtgcagcagc tggaacggtc catcggcctg aaggacctgg ccatggctga cctggaacag      780

aaagtgctgg aaatggaagc ctccacacag gtgtcacaca gatacccccg gatccagtcc      840

attaaggtgc agttcaccga gtacaagaaa gagaagggct ttatcctgac ctcccagaaa      900

gaggacgaga tcatgaaggt gcagaacaac tccgtgatca tcaactgcga cgggttctac      960

ctgatctccc tgaagggcta cttcagccag gaagtgaaca tctccctgca ctaccagaag     1020

gacgaggaac ccctgttcca gctgaagaaa gtgcggagcg tgaactccct gatggtggcc     1080

tctctgacct acaaggacaa ggtgtacctg aacgtgacca ccgacaacac ctccctggac     1140

gacttccacg tgaacggcgg cgagctgatc ctgatccacc agaaccctgg cgaggcctgc     1200

gtgctg                                                                1206


<210>  34
<211>  1206
<212>  PRT
<213>  Homo Sapiens
<223>  Amino Acid Sequence of huIgG4PFcTF2OX40L F180A (N to C terminus)

<400>  34

Gly Ala Gly Ala Gly Cys Ala Ala Gly Thr Ala Cys Gly Gly Cys Cys 
1               5                   10                  15      


Cys Thr Cys Cys Cys Thr Gly Cys Cys Cys Cys Cys Cys Thr Thr Gly 
            20                  25                  30          


Cys Cys Cys Thr Gly Cys Cys Cys Cys Cys Gly Ala Gly Thr Thr Cys 
        35                  40                  45              


Cys Thr Gly Gly Gly Cys Gly Gly Ala Cys Cys Thr Ala Gly Cys Gly 
    50                  55                  60                  


Thr Gly Thr Thr Cys Cys Thr Gly Thr Thr Cys Cys Cys Cys Cys Cys 
65                  70                  75                  80  


Cys Ala Ala Gly Cys Cys Cys Ala Ala Gly Gly Ala Cys Ala Cys Cys 
                85                  90                  95      


Cys Thr Gly Ala Thr Gly Ala Thr Cys Ala Gly Cys Ala Gly Ala Ala 
            100                 105                 110         


Cys Cys Cys Cys Cys Gly Ala Gly Gly Thr Gly Ala Cys Cys Thr Gly 
        115                 120                 125             


Cys Gly Thr Gly Gly Thr Gly Gly Thr Gly Gly Ala Cys Gly Thr Gly 
    130                 135                 140                 


Thr Cys Cys Cys Ala Gly Gly Ala Gly Gly Ala Cys Cys Cys Cys Gly 
145                 150                 155                 160 


Ala Gly Gly Thr Cys Cys Ala Gly Thr Thr Thr Ala Ala Thr Thr Gly 
                165                 170                 175     


Gly Thr Ala Cys Gly Thr Gly Gly Ala Cys Gly Gly Cys Gly Thr Gly 
            180                 185                 190         


Gly Ala Ala Gly Thr Gly Cys Ala Thr Ala Ala Cys Gly Cys Cys Ala 
        195                 200                 205             


Ala Gly Ala Cys Cys Ala Ala Gly Cys Cys Cys Ala Gly Ala Gly Ala 
    210                 215                 220                 


Gly Gly Ala Gly Cys Ala Gly Thr Thr Cys Ala Ala Cys Ala Gly Cys 
225                 230                 235                 240 


Ala Cys Cys Thr Ala Cys Ala Gly Ala Gly Thr Gly Gly Thr Gly Thr 
                245                 250                 255     


Cys Cys Gly Thr Gly Cys Thr Gly Ala Cys Cys Gly Thr Gly Cys Thr 
            260                 265                 270         


Gly Cys Ala Cys Cys Ala Gly Gly Ala Cys Thr Gly Gly Cys Thr Gly 
        275                 280                 285             


Ala Ala Cys Gly Gly Cys Ala Ala Gly Gly Ala Ala Thr Ala Cys Ala 
    290                 295                 300                 


Ala Gly Thr Gly Cys Ala Ala Gly Gly Thr Cys Thr Cys Cys Ala Ala 
305                 310                 315                 320 


Cys Ala Ala Gly Gly Gly Cys Cys Thr Gly Cys Cys Thr Ala Gly Cys 
                325                 330                 335     


Ala Gly Cys Ala Thr Cys Gly Ala Gly Ala Ala Gly Ala Cys Cys Ala 
            340                 345                 350         


Thr Cys Ala Gly Cys Ala Ala Gly Gly Cys Cys Ala Ala Gly Gly Gly 
        355                 360                 365             


Cys Cys Ala Gly Cys Cys Ala Cys Gly Gly Gly Ala Gly Cys Cys Cys 
    370                 375                 380                 


Cys Ala Gly Gly Thr Cys Thr Ala Cys Ala Cys Cys Cys Thr Gly Cys 
385                 390                 395                 400 


Cys Ala Cys Cys Thr Ala Gly Cys Cys Ala Ala Gly Ala Gly Gly Ala 
                405                 410                 415     


Gly Ala Thr Gly Ala Cys Cys Ala Ala Gly Ala Ala Cys Cys Ala Gly 
            420                 425                 430         


Gly Thr Gly Thr Cys Cys Cys Thr Gly Ala Cys Cys Thr Gly Thr Cys 
        435                 440                 445             


Thr Gly Gly Thr Gly Ala Ala Ala Gly Gly Cys Thr Thr Cys Thr Ala 
    450                 455                 460                 


Thr Cys Cys Cys Ala Gly Cys Gly Ala Thr Ala Thr Cys Gly Cys Cys 
465                 470                 475                 480 


Gly Thr Gly Gly Ala Gly Thr Gly Gly Gly Ala Gly Ala Gly Cys Ala 
                485                 490                 495     


Ala Cys Gly Gly Cys Cys Ala Gly Cys Cys Cys Gly Ala Gly Ala Ala 
            500                 505                 510         


Cys Ala Ala Cys Thr Ala Cys Ala Ala Gly Ala Cys Cys Ala Cys Cys 
        515                 520                 525             


Cys Cys Cys Cys Cys Thr Gly Thr Gly Cys Thr Gly Gly Ala Cys Ala 
    530                 535                 540                 


Gly Cys Gly Ala Cys Gly Gly Cys Ala Gly Cys Thr Thr Cys Thr Thr 
545                 550                 555                 560 


Cys Cys Thr Gly Thr Ala Cys Thr Cys Cys Ala Gly Ala Cys Thr Gly 
                565                 570                 575     


Ala Cys Cys Gly Thr Gly Gly Ala Cys Ala Ala Gly Thr Cys Cys Ala 
            580                 585                 590         


Gly Ala Thr Gly Gly Cys Ala Gly Gly Ala Gly Gly Gly Cys Ala Ala 
        595                 600                 605             


Cys Gly Thr Cys Thr Thr Cys Ala Gly Cys Thr Gly Cys Thr Cys Cys 
    610                 615                 620                 


Gly Thr Gly Ala Thr Gly Cys Ala Cys Gly Ala Gly Gly Cys Cys Cys 
625                 630                 635                 640 


Thr Gly Cys Ala Cys Ala Ala Cys Cys Ala Cys Thr Ala Cys Ala Cys 
                645                 650                 655     


Cys Cys Ala Gly Ala Ala Gly Thr Cys Cys Cys Thr Gly Ala Gly Cys 
            660                 665                 670         


Cys Thr Gly Ala Gly Cys Cys Thr Gly Gly Gly Cys Ala Ala Gly Gly 
        675                 680                 685             


Ala Cys Cys Ala Gly Gly Ala Thr Ala Ala Gly Ala Thr Cys Gly Ala 
    690                 695                 700                 


Gly Gly Cys Thr Cys Thr Gly Thr Cys Cys Thr Cys Cys Ala Ala Gly 
705                 710                 715                 720 


Gly Thr Gly Cys Ala Gly Cys Ala Gly Cys Thr Gly Gly Ala Ala Cys 
                725                 730                 735     


Gly Gly Thr Cys Cys Ala Thr Cys Gly Gly Cys Cys Thr Gly Ala Ala 
            740                 745                 750         


Gly Gly Ala Cys Cys Thr Gly Gly Cys Cys Ala Thr Gly Gly Cys Thr 
        755                 760                 765             


Gly Ala Cys Cys Thr Gly Gly Ala Ala Cys Ala Gly Ala Ala Ala Gly 
    770                 775                 780                 


Thr Gly Cys Thr Gly Gly Ala Ala Ala Thr Gly Gly Ala Ala Gly Cys 
785                 790                 795                 800 


Cys Thr Cys Cys Ala Cys Ala Cys Ala Gly Gly Thr Gly Thr Cys Ala 
                805                 810                 815     


Cys Ala Cys Ala Gly Ala Thr Ala Cys Cys Cys Cys Cys Gly Gly Ala 
            820                 825                 830         


Thr Cys Cys Ala Gly Thr Cys Cys Ala Thr Thr Ala Ala Gly Gly Thr 
        835                 840                 845             


Gly Cys Ala Gly Thr Thr Cys Ala Cys Cys Gly Ala Gly Thr Ala Cys 
    850                 855                 860                 


Ala Ala Gly Ala Ala Ala Gly Ala Gly Ala Ala Gly Gly Gly Cys Thr 
865                 870                 875                 880 


Thr Thr Ala Thr Cys Cys Thr Gly Ala Cys Cys Thr Cys Cys Cys Ala 
                885                 890                 895     


Gly Ala Ala Ala Gly Ala Gly Gly Ala Cys Gly Ala Gly Ala Thr Cys 
            900                 905                 910         


Ala Thr Gly Ala Ala Gly Gly Thr Gly Cys Ala Gly Ala Ala Cys Ala 
        915                 920                 925             


Ala Cys Thr Cys Cys Gly Thr Gly Ala Thr Cys Ala Thr Cys Ala Ala 
    930                 935                 940                 


Cys Thr Gly Cys Gly Ala Cys Gly Gly Gly Thr Thr Cys Thr Ala Cys 
945                 950                 955                 960 


Cys Thr Gly Ala Thr Cys Thr Cys Cys Cys Thr Gly Ala Ala Gly Gly 
                965                 970                 975     


Gly Cys Thr Ala Cys Thr Thr Cys Ala Gly Cys Cys Ala Gly Gly Ala 
            980                 985                 990         


Ala Gly Thr Gly Ala Ala Cys Ala  Thr Cys Thr Cys Cys  Cys Thr Gly 
        995                 1000                 1005             


Cys Ala  Cys Thr Ala Cys Cys  Ala Gly Ala Ala Gly  Gly Ala Cys 
    1010                 1015                 1020             


Gly Ala  Gly Gly Ala Ala Cys  Cys Cys Cys Thr Gly  Thr Thr Cys 
    1025                 1030                 1035             


Cys Ala  Gly Cys Thr Gly Ala  Ala Gly Ala Ala Ala  Gly Thr Gly 
    1040                 1045                 1050             


Cys Gly  Gly Ala Gly Cys Gly  Thr Gly Ala Ala Cys  Thr Cys Cys 
    1055                 1060                 1065             


Cys Thr  Gly Ala Thr Gly Gly  Thr Gly Gly Cys Cys  Thr Cys Thr 
    1070                 1075                 1080             


Cys Thr  Gly Ala Cys Cys Thr  Ala Cys Ala Ala Gly  Gly Ala Cys 
    1085                 1090                 1095             


Ala Ala  Gly Gly Thr Gly Thr  Ala Cys Cys Thr Gly  Ala Ala Cys 
    1100                 1105                 1110             


Gly Thr  Gly Ala Cys Cys Ala  Cys Cys Gly Ala Cys  Ala Ala Cys 
    1115                 1120                 1125             


Ala Cys  Cys Thr Cys Cys Cys  Thr Gly Gly Ala Cys  Gly Ala Cys 
    1130                 1135                 1140             


Thr Thr  Cys Cys Ala Cys Gly  Thr Gly Ala Ala Cys  Gly Gly Cys 
    1145                 1150                 1155             


Gly Gly  Cys Gly Ala Gly Cys  Thr Gly Ala Thr Cys  Cys Thr Gly 
    1160                 1165                 1170             


Ala Thr  Cys Cys Ala Cys Cys  Ala Gly Ala Ala Cys  Cys Cys Thr 
    1175                 1180                 1185             


Gly Gly  Cys Gly Ala Gly Gly  Cys Cys Thr Gly Cys  Gly Thr Gly 
    1190                 1195                 1200             


Cys Thr  Gly 
    1205     


<210>  35
<211>  1200
<212>  DNA
<213>  Homo sapiens
<223>  DNA Sequence of huIgG1TF2OX40L (5 to 3 Open Reading Frame)

<400>  35
gataagaccc acacctgtcc cccttgtcct gcccctgaac tgctgggcgg accttccgtg       60

ttcctgttcc ccccaaagcc caaggacacc ctgatgatct cccggacccc cgaagtgacc      120

tgcgtggtgg tggatgtgtc ccacgaggac cctgaagtga agttcaattg gtacgtggac      180

ggcgtggaag tgcacaacgc caagaccaag cccagagagg aacagtacaa ctccacctac      240

cgggtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa agagtacaag      300

tgcaaggtgt ccaacaaggc cctgcctgcc cccatcgaaa agaccatctc caaggccaag      360

ggccagcccc gggaacccca ggtgtacaca ctgcccccta gccgggaaga gatgaccaag      420

aaccaggtgt ccctgacctg tctcgtgaag ggcttctacc cctccgatat cgccgtggaa      480

tgggagtcca acggccagcc tgagaacaac tacaagacca ccccccctgt gctggactcc      540

gacggctcat tcttcctgta ctccaagctg acagtggaca agtcccggtg gcagcagggc      600

aacgtgttct cctgctccgt gatgcacgag gccctgcaca accactacac ccagaagtcc      660

ctgtccctga gccccggcaa ggaccaggat aagatcgagg ctctgtcctc caaggtgcag      720

cagctggaac ggtccatcgg cctgaaggac ctggccatgg ctgacctgga acagaaagtg      780

ctggaaatgg aagcctccac acaggtgtca cacagatacc cccggatcca gtccattaag      840

gtgcagttca ccgagtacaa gaaagagaag ggctttatcc tgacctccca gaaagaggac      900

gagatcatga aggtgcagaa caactccgtg atcatcaact gcgacgggtt ctacctgatc      960

tccctgaagg gctacttcag ccaggaagtg aacatctccc tgcactacca gaaggacgag     1020

gaacccctgt tccagctgaa gaaagtgcgg agcgtgaact ccctgatggt ggcctctctg     1080

acctacaagg acaaggtgta cctgaacgtg accaccgaca acacctccct ggacgacttc     1140

cacgtgaacg gcggcgagct gatcctgatc caccagaacc ctggcgagtt ctgcgtgctg     1200


<210>  36
<211>  400
<212>  PRT
<213>  Homo sapiens
<223>  Amino Acid Sequence of huIgG1FcTF2OX40L (N to C terminus)

<400>  36



Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Asp Gln Asp Lys Ile Glu Ala Leu Ser Ser Lys Val Gln 
225                 230                 235                 240 


Gln Leu Glu Arg Ser Ile Gly Leu Lys Asp Leu Ala Met Ala Asp Leu 
                245                 250                 255     


Glu Gln Lys Val Leu Glu Met Glu Ala Ser Thr Gln Val Ser His Arg 
            260                 265                 270         


Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys Lys 
        275                 280                 285             


Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp Glu Ile Met Lys 
    290                 295                 300                 


Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp Gly Phe Tyr Leu Ile 
305                 310                 315                 320 


Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile Ser Leu His Tyr 
                325                 330                 335     


Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys Val Arg Ser Val 
            340                 345                 350         


Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr Leu 
        355                 360                 365             


Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe His Val Asn Gly 
    370                 375                 380                 


Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly Glu Phe Cys Val Leu 
385                 390                 395                 400 


<210>  37
<211>  1248
<212>  DNA
<213>  Mus musculis
<223>  DNA Sequence of mouse construct mIgG1mTF2mOX40L (5 to 3 Open Reading Frame)

<400>  37
gtgcctagag attgcggctg caagccctgc atctgcaccg tgcccgaggt gtccagcgtg       60

ttcatcttcc cacccaagcc caaggacgtg ctgaccatca ccctgacccc caaagtgacc      120

tgcgtggtgg tggacatcag caaggacgac cccgaggtgc agttcagttg gttcgtggac      180

gacgtggaag tgcacaccgc ccagacccag cccagagagg aacagttcaa cagcaccttc      240

agaagcgtgt ccgagctgcc catcatgcac caggactggc tgaacggcaa agaattcaag      300

tgcagagtga acagcgccgc cttccctgcc cccatcgaga aaaccatcag caagaccaag      360

ggcagaccca aggcccccca ggtgtacacc atccccccac ccaaagaaca gatggccaag      420

gacaaggtgt ccctgacctg catgatcacc gatttcttcc cagaggacat caccgtggaa      480

tggcagtgga acggccagcc cgccgagaac tacaagaaca cccagcccat catggacacc      540

gacggcagct acttcgtgta cagcaagctg aacgtgcaga agtccaactg ggaggccggc      600

aacaccttca cctgtagcgt gctgcacgag ggcctgcaca accaccacac cgagaagtcc      660

ctgagccaca gccccggcaa gcggctggac caggacaaga tcgaggccct gagcaacaag      720

gtgcagcagc tggaacggtc tatcggcctg aaggacctgg ctatggccga cctggaacag      780

aaagtgtctg agctggaagt gtccaccagc agccccgcca aggaccctcc catccagaga      840

ctgagaggcg ccgtgaccag atgcgaggac ggccagctgt tcatcagcag ctacaagaac      900

gagtaccaga ccatggaagt gcagaacaac agcgtggtca tcaagtgcga cggcctgtac      960

atcatctacc tcaagggcag cttcttccag gaagtgaaga tcgacctgca cttcagagag     1020

gaccacaacc ccatcagcat ccccatgctg aacgacggca gacggatcgt gttcaccgtg     1080

gtggctagcc tggccttcaa ggacaaagtg tatctgaccg tgaacgcccc cgacaccctg     1140

tgcgagcatc tgcagatcaa cgacggcgag ctgatcgtgg tgcagctgac ccccggctac     1200

tgtgcccctg agggcagcta ccacagcacc gtgaaccagg tgcccctg                  1248


<210>  38
<211>  416
<212>  PRT
<213>  Mus musculis
<223>  Amino Acid Sequence of mouse construct mIgG1FcmTF2mOX40L (N to C terminus)

<400>  38

Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu 
1               5                   10                  15      


Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr 
            20                  25                  30          


Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys 
        35                  40                  45              


Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val 
    50                  55                  60                  


His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
65                  70                  75                  80  


Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val 
        115                 120                 125             


Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser 
    130                 135                 140                 


Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu 
145                 150                 155                 160 


Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro 
                165                 170                 175     


Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val 
            180                 185                 190         


Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu 
        195                 200                 205             


His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser 
    210                 215                 220                 


Pro Gly Lys Arg Leu Asp Gln Asp Lys Ile Glu Ala Leu Ser Asn Lys 
225                 230                 235                 240 


Val Gln Gln Leu Glu Arg Ser Ile Gly Leu Lys Asp Leu Ala Met Ala 
                245                 250                 255     


Asp Leu Glu Gln Lys Val Ser Glu Leu Glu Val Ser Thr Ser Ser Pro 
            260                 265                 270         


Ala Lys Asp Pro Pro Ile Gln Arg Leu Arg Gly Ala Val Thr Arg Cys 
        275                 280                 285             


Glu Asp Gly Gln Leu Phe Ile Ser Ser Tyr Lys Asn Glu Tyr Gln Thr 
    290                 295                 300                 


Met Glu Val Gln Asn Asn Ser Val Val Ile Lys Cys Asp Gly Leu Tyr 
305                 310                 315                 320 


Ile Ile Tyr Leu Lys Gly Ser Phe Phe Gln Glu Val Lys Ile Asp Leu 
                325                 330                 335     


His Phe Arg Glu Asp His Asn Pro Ile Ser Ile Pro Met Leu Asn Asp 
            340                 345                 350         


Gly Arg Arg Ile Val Phe Thr Val Val Ala Ser Leu Ala Phe Lys Asp 
        355                 360                 365             


Lys Val Tyr Leu Thr Val Asn Ala Pro Asp Thr Leu Cys Glu His Leu 
    370                 375                 380                 


Gln Ile Asn Asp Gly Glu Leu Ile Val Val Gln Leu Thr Pro Gly Tyr 
385                 390                 395                 400 


Cys Ala Pro Glu Gly Ser Tyr His Ser Thr Val Asn Gln Val Pro Leu 
                405                 410                 415     