                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
       President And Fellows Of Harvard College
 
<120>  Compositions And Methods For Identification, Assessment, 
       Prevention, And Treatment Of T-Cell Exhaustion Using CD39 
       Biomarkers And Modulators

<130>  DFS-141.25

<140>  PCT/US2015/055938
<141>  2015-10-16

<150>  62/065,192
<151>  2014-10-17

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  1533
<212>  DNA
<213>  Homo sapiens

<400>  1
atggaagata caaaggagtc taacgtgaag acattttgct ccaagaatat cctagccatc       60

cttggcttct cctctatcat agctgtgata gctttgcttg ctgtggggtt gacccagaac      120

aaagcattgc cagaaaacgt taagtatggg attgtgctgg atgcgggttc ttctcacaca      180

agtttataca tctataagtg gccagcagaa aaggagaatg acacaggcgt ggtgcatcaa      240

gtagaagaat gcagggttaa aggtcctgga atctcaaaat ttgttcagaa agtaaatgaa      300

ataggcattt acctgactga ttgcatggaa agagctaggg aagtgattcc aaggtcccag      360

caccaagaga cacccgttta cctgggagcc acggcaggca tgcggttgct caggatggaa      420

agtgaagagt tggcagacag ggttctggat gtggtggaga ggagcctcag caactacccc      480

tttgacttcc agggtgccag gatcattact ggccaagagg aaggtgccta tggctggatt      540

actatcaact atctgctggg caaattcagt cagaaaacaa ggtggttcag catagtccca      600

tatgaaacca ataatcagga aacctttgga gctttggacc ttgggggagc ctctacacaa      660

gtcacttttg taccccaaaa ccagactatc gagtccccag ataatgctct gcaatttcgc      720

ctctatggca aggactacaa tgtctacaca catagcttct tgtgctatgg gaaggatcag      780

gcactctggc agaaactggc caaggacatt caggttgcaa gtaatgaaat tctcagggac      840

ccatgctttc atcctggata taagaaggta gtgaacgtaa gtgaccttta caagaccccc      900

tgcaccaaga gatttgagat gactcttcca ttccagcagt ttgaaatcca gggtattgga      960

aactatcaac aatgccatca aagcatcctg gagctcttca acaccagtta ctgcccttac     1020

tcccagtgtg ccttcaatgg gattttcttg ccaccactcc agggggattt tggggcattt     1080

tcagcttttt actttgtgat gaagttttta aacttgacat cagagaaagt ctctcaggaa     1140

aaggtgactg agatgatgaa aaagttctgt gctcagcctt gggaggagat aaaaacatct     1200

tacgctggag taaaggagaa gtacctgagt gaatactgct tttctggtac ctacattctc     1260

tccctccttc tgcaaggcta tcatttcaca gctgattcct gggagcacat ccatttcatt     1320

ggcaagatcc agggcagcga cgccggctgg actttgggct acatgctgaa cctgaccaac     1380

atgatcccag ctgagcaacc attgtccaca cctctctccc actccaccta tgtcttcctc     1440

atggttctat tctccctggt ccttttcaca gtggccatca taggcttgct tatctttcac     1500

aagccttcat atttctggaa agatatggta tag                                  1533


<210>  2
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Asp Thr Lys Glu Ser Asn Val Lys Thr Phe Cys Ser Lys Asn 
1               5                   10                  15      


Ile Leu Ala Ile Leu Gly Phe Ser Ser Ile Ile Ala Val Ile Ala Leu 
            20                  25                  30          


Leu Ala Val Gly Leu Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys 
        35                  40                  45              


Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile 
    50                  55                  60                  


Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val His Gln 
65                  70                  75                  80  


Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln 
                85                  90                  95      


Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala 
            100                 105                 110         


Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu 
        115                 120                 125             


Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu 
    130                 135                 140                 


Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro 
145                 150                 155                 160 


Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala 
                165                 170                 175     


Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys 
            180                 185                 190         


Thr Arg Trp Phe Ser Ile Val Pro Tyr Glu Thr Asn Asn Gln Glu Thr 
        195                 200                 205             


Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val 
    210                 215                 220                 


Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg 
225                 230                 235                 240 


Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr 
                245                 250                 255     


Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val 
            260                 265                 270         


Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys 
        275                 280                 285             


Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg 
    290                 295                 300                 


Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly 
305                 310                 315                 320 


Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser 
                325                 330                 335     


Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro 
            340                 345                 350         


Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys 
        355                 360                 365             


Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu 
    370                 375                 380                 


Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser 
385                 390                 395                 400 


Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly 
                405                 410                 415     


Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp 
            420                 425                 430         


Ser Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala 
        435                 440                 445             


Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala 
    450                 455                 460                 


Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr Tyr Val Phe Leu 
465                 470                 475                 480 


Met Val Leu Phe Ser Leu Val Leu Phe Thr Val Ala Ile Ile Gly Leu 
                485                 490                 495     


Leu Ile Phe His Lys Pro Ser Tyr Phe Trp Lys Asp Met Val 
            500                 505                 510 


<210>  3
<211>  1554
<212>  DNA
<213>  Homo sapiens

<400>  3
atgaagggaa ccaaggacct gacaagccag cagaaggagt ctaacgtgaa gacattttgc       60

tccaagaata tcctagccat ccttggcttc tcctctatca tagctgtgat agctttgctt      120

gctgtggggt tgacccagaa caaagcattg ccagaaaacg ttaagtatgg gattgtgctg      180

gatgcgggtt cttctcacac aagtttatac atctataagt ggccagcaga aaaggagaat      240

gacacaggcg tggtgcatca agtagaagaa tgcagggtta aaggtcctgg aatctcaaaa      300

tttgttcaga aagtaaatga aataggcatt tacctgactg attgcatgga aagagctagg      360

gaagtgattc caaggtccca gcaccaagag acacccgttt acctgggagc cacggcaggc      420

atgcggttgc tcaggatgga aagtgaagag ttggcagaca gggttctgga tgtggtggag      480

aggagcctca gcaactaccc ctttgacttc cagggtgcca ggatcattac tggccaagag      540

gaaggtgcct atggctggat tactatcaac tatctgctgg gcaaattcag tcagaaaaca      600

aggtggttca gcatagtccc atatgaaacc aataatcagg aaacctttgg agctttggac      660

cttgggggag cctctacaca agtcactttt gtaccccaaa accagactat cgagtcccca      720

gataatgctc tgcaatttcg cctctatggc aaggactaca atgtctacac acatagcttc      780

ttgtgctatg ggaaggatca ggcactctgg cagaaactgg ccaaggacat tcaggttgca      840

agtaatgaaa ttctcaggga cccatgcttt catcctggat ataagaaggt agtgaacgta      900

agtgaccttt acaagacccc ctgcaccaag agatttgaga tgactcttcc attccagcag      960

tttgaaatcc agggtattgg aaactatcaa caatgccatc aaagcatcct ggagctcttc     1020

aacaccagtt actgccctta ctcccagtgt gccttcaatg ggattttctt gccaccactc     1080

cagggggatt ttggggcatt ttcagctttt tactttgtga tgaagttttt aaacttgaca     1140

tcagagaaag tctctcagga aaaggtgact gagatgatga aaaagttctg tgctcagcct     1200

tgggaggaga taaaaacatc ttacgctgga gtaaaggaga agtacctgag tgaatactgc     1260

ttttctggta cctacattct ctccctcctt ctgcaaggct atcatttcac agctgattcc     1320

tgggagcaca tccatttcat tggcaagatc cagggcagcg acgccggctg gactttgggc     1380

tacatgctga acctgaccaa catgatccca gctgagcaac cattgtccac acctctctcc     1440

cactccacct atgtcttcct catggttcta ttctccctgg tccttttcac agtggccatc     1500

ataggcttgc ttatctttca caagccttca tatttctgga aagatatggt atag           1554


<210>  4
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Lys Gly Thr Lys Asp Leu Thr Ser Gln Gln Lys Glu Ser Asn Val 
1               5                   10                  15      


Lys Thr Phe Cys Ser Lys Asn Ile Leu Ala Ile Leu Gly Phe Ser Ser 
            20                  25                  30          


Ile Ile Ala Val Ile Ala Leu Leu Ala Val Gly Leu Thr Gln Asn Lys 
        35                  40                  45              


Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser 
    50                  55                  60                  


Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn 
65                  70                  75                  80  


Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg Val Lys Gly Pro 
                85                  90                  95      


Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile Gly Ile Tyr Leu 
            100                 105                 110         


Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro Arg Ser Gln His 
        115                 120                 125             


Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly Met Arg Leu Leu 
    130                 135                 140                 


Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu Asp Val Val Glu 
145                 150                 155                 160 


Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile 
                165                 170                 175     


Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu 
            180                 185                 190         


Leu Gly Lys Phe Ser Gln Lys Thr Arg Trp Phe Ser Ile Val Pro Tyr 
        195                 200                 205             


Glu Thr Asn Asn Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala 
    210                 215                 220                 


Ser Thr Gln Val Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro 
225                 230                 235                 240 


Asp Asn Ala Leu Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr 
                245                 250                 255     


Thr His Ser Phe Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys 
            260                 265                 270         


Leu Ala Lys Asp Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro 
        275                 280                 285             


Cys Phe His Pro Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr 
    290                 295                 300                 


Lys Thr Pro Cys Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln 
305                 310                 315                 320 


Phe Glu Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile 
                325                 330                 335     


Leu Glu Leu Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe 
            340                 345                 350         


Asn Gly Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser 
        355                 360                 365             


Ala Phe Tyr Phe Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val 
    370                 375                 380                 


Ser Gln Glu Lys Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro 
385                 390                 395                 400 


Trp Glu Glu Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu 
                405                 410                 415     


Ser Glu Tyr Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln 
            420                 425                 430         


Gly Tyr His Phe Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly 
        435                 440                 445             


Lys Ile Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn 
    450                 455                 460                 


Leu Thr Asn Met Ile Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser 
465                 470                 475                 480 


His Ser Thr Tyr Val Phe Leu Met Val Leu Phe Ser Leu Val Leu Phe 
                485                 490                 495     


Thr Val Ala Ile Ile Gly Leu Leu Ile Phe His Lys Pro Ser Tyr Phe 
            500                 505                 510         


Trp Lys Asp Met Val 
        515         


<210>  5
<211>  1569
<212>  DNA
<213>  Homo sapiens

<400>  5
atggggaggg aagaactgtt cttgactttc agtttttcga gcgggtttca agagtctaac       60

gtgaagacat tttgctccaa gaatatccta gccatccttg gcttctcctc tatcatagct      120

gtgatagctt tgcttgctgt ggggttgacc cagaacaaag cattgccaga aaacgttaag      180

tatgggattg tgctggatgc gggttcttct cacacaagtt tatacatcta taagtggcca      240

gcagaaaagg agaatgacac aggcgtggtg catcaagtag aagaatgcag ggttaaaggt      300

cctggaatct caaaatttgt tcagaaagta aatgaaatag gcatttacct gactgattgc      360

atggaaagag ctagggaagt gattccaagg tcccagcacc aagagacacc cgtttacctg      420

ggagccacgg caggcatgcg gttgctcagg atggaaagtg aagagttggc agacagggtt      480

ctggatgtgg tggagaggag cctcagcaac tacccctttg acttccaggg tgccaggatc      540

attactggcc aagaggaagg tgcctatggc tggattacta tcaactatct gctgggcaaa      600

ttcagtcaga aaacaaggtg gttcagcata gtcccatatg aaaccaataa tcaggaaacc      660

tttggagctt tggaccttgg gggagcctct acacaagtca cttttgtacc ccaaaaccag      720

actatcgagt ccccagataa tgctctgcaa tttcgcctct atggcaagga ctacaatgtc      780

tacacacata gcttcttgtg ctatgggaag gatcaggcac tctggcagaa actggccaag      840

gacattcagg ttgcaagtaa tgaaattctc agggacccat gctttcatcc tggatataag      900

aaggtagtga acgtaagtga cctttacaag accccctgca ccaagagatt tgagatgact      960

cttccattcc agcagtttga aatccagggt attggaaact atcaacaatg ccatcaaagc     1020

atcctggagc tcttcaacac cagttactgc ccttactccc agtgtgcctt caatgggatt     1080

ttcttgccac cactccaggg ggattttggg gcattttcag ctttttactt tgtgatgaag     1140

tttttaaact tgacatcaga gaaagtctct caggaaaagg tgactgagat gatgaaaaag     1200

ttctgtgctc agccttggga ggagataaaa acatcttacg ctggagtaaa ggagaagtac     1260

ctgagtgaat actgcttttc tggtacctac attctctccc tccttctgca aggctatcat     1320

ttcacagctg attcctggga gcacatccat ttcattggca agatccaggg cagcgacgcc     1380

ggctggactt tgggctacat gctgaacctg accaacatga tcccagctga gcaaccattg     1440

tccacacctc tctcccactc cacctatgtc ttcctcatgg ttctattctc cctggtcctt     1500

ttcacagtgg ccatcatagg cttgcttatc tttcacaagc cttcatattt ctggaaagat     1560

atggtatag                                                             1569


<210>  6
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gly Arg Glu Glu Leu Phe Leu Thr Phe Ser Phe Ser Ser Gly Phe 
1               5                   10                  15      


Gln Glu Ser Asn Val Lys Thr Phe Cys Ser Lys Asn Ile Leu Ala Ile 
            20                  25                  30          


Leu Gly Phe Ser Ser Ile Ile Ala Val Ile Ala Leu Leu Ala Val Gly 
        35                  40                  45              


Leu Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val 
    50                  55                  60                  


Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro 
65                  70                  75                  80  


Ala Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys 
                85                  90                  95      


Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu 
            100                 105                 110         


Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile 
        115                 120                 125             


Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala 
    130                 135                 140                 


Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val 
145                 150                 155                 160 


Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln 
                165                 170                 175     


Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile 
            180                 185                 190         


Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Thr Arg Trp Phe 
        195                 200                 205             


Ser Ile Val Pro Tyr Glu Thr Asn Asn Gln Glu Thr Phe Gly Ala Leu 
    210                 215                 220                 


Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro Gln Asn Gln 
225                 230                 235                 240 


Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu Tyr Gly Lys 
                245                 250                 255     


Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly Lys Asp Gln 
            260                 265                 270         


Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala Ser Asn Glu 
        275                 280                 285             


Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys Val Val Asn 
    290                 295                 300                 


Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe Glu Met Thr 
305                 310                 315                 320 


Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn Tyr Gln Gln 
                325                 330                 335     


Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr Cys Pro Tyr 
            340                 345                 350         


Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu Gln Gly Asp 
        355                 360                 365             


Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe Leu Asn Leu 
    370                 375                 380                 


Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met Met Lys Lys 
385                 390                 395                 400 


Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr Ala Gly Val 
                405                 410                 415     


Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr Tyr Ile Leu 
            420                 425                 430         


Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser Trp Glu His 
        435                 440                 445             


Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly Trp Thr Leu 
    450                 455                 460                 


Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu Gln Pro Leu 
465                 470                 475                 480 


Ser Thr Pro Leu Ser His Ser Thr Tyr Val Phe Leu Met Val Leu Phe 
                485                 490                 495     


Ser Leu Val Leu Phe Thr Val Ala Ile Ile Gly Leu Leu Ile Phe His 
            500                 505                 510         


Lys Pro Ser Tyr Phe Trp Lys Asp Met Val 
        515                 520         


<210>  7
<211>  1410
<212>  DNA
<213>  Homo sapiens

<400>  7
atggaagata caaaggagtc taacgtgaag acattttgct ccaagaatat cctagccatc       60

cttggcttct cctctatcat agctgtgata gctttgcttg ctgtggggtt gacccagaac      120

aaagcattgc cagaaaacgt taagtatggg attgtgctgg atgcgggttc ttctcacaca      180

agtttataca tctataagtg gccagcagaa aaggagaatg acacaggcgt ggtgcatcaa      240

gtagaagaat gcagggttaa aggtcctgga atctcaaaat ttgttcagaa agtaaatgaa      300

ataggcattt acctgactga ttgcatggaa agagctaggg aagtgattcc aaggtcccag      360

caccaagaga cacccgttta cctgggagcc acggcaggca tgcggttgct caggatggaa      420

agtgaagagt tggcagacag ggttctggat gtggtggaga ggagcctcag caactacccc      480

tttgacttcc agggtgccag gatcattact ggccaagagg aaggtgccta tggctggatt      540

actatcaact atctgctggg caaattcagt cagaaaacaa ggtggttcag catagtccca      600

tatgaaacca ataatcagga aacctttgga gctttggacc ttgggggagc ctctacacaa      660

gtcacttttg taccccaaaa ccagactatc gagtccccag ataatgctct gcaatttcgc      720

ctctatggca aggactacaa tgtctacaca catagcttct tgtgctatgg gaaggatcag      780

gcactctggc agaaactggc caaggacatt cagcagtttg aaatccaggg tattggaaac      840

tatcaacaat gccatcaaag catcctggag ctcttcaaca ccagttactg cccttactcc      900

cagtgtgcct tcaatgggat tttcttgcca ccactccagg gggattttgg ggcattttca      960

gctttttact ttgtgatgaa gtttttaaac ttgacatcag agaaagtctc tcaggaaaag     1020

gtgactgaga tgatgaaaaa gttctgtgct cagccttggg aggagataaa aacatcttac     1080

gctggagtaa aggagaagta cctgagtgaa tactgctttt ctggtaccta cattctctcc     1140

ctccttctgc aaggctatca tttcacagct gattcctggg agcacatcca tttcattggc     1200

aagatccagg gcagcgacgc cggctggact ttgggctaca tgctgaacct gaccaacatg     1260

atcccagctg agcaaccatt gtccacacct ctctcccact ccacctatgt cttcctcatg     1320

gttctattct ccctggtcct tttcacagtg gccatcatag gcttgcttat ctttcacaag     1380

ccttcatatt tctggaaaga tatggtatag                                      1410


<210>  8
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Asp Thr Lys Glu Ser Asn Val Lys Thr Phe Cys Ser Lys Asn 
1               5                   10                  15      


Ile Leu Ala Ile Leu Gly Phe Ser Ser Ile Ile Ala Val Ile Ala Leu 
            20                  25                  30          


Leu Ala Val Gly Leu Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys 
        35                  40                  45              


Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile 
    50                  55                  60                  


Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val His Gln 
65                  70                  75                  80  


Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln 
                85                  90                  95      


Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala 
            100                 105                 110         


Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu 
        115                 120                 125             


Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu 
    130                 135                 140                 


Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro 
145                 150                 155                 160 


Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala 
                165                 170                 175     


Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys 
            180                 185                 190         


Thr Arg Trp Phe Ser Ile Val Pro Tyr Glu Thr Asn Asn Gln Glu Thr 
        195                 200                 205             


Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val 
    210                 215                 220                 


Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg 
225                 230                 235                 240 


Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr 
                245                 250                 255     


Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Gln 
            260                 265                 270         


Phe Glu Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile 
        275                 280                 285             


Leu Glu Leu Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe 
    290                 295                 300                 


Asn Gly Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser 
305                 310                 315                 320 


Ala Phe Tyr Phe Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val 
                325                 330                 335     


Ser Gln Glu Lys Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro 
            340                 345                 350         


Trp Glu Glu Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu 
        355                 360                 365             


Ser Glu Tyr Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln 
    370                 375                 380                 


Gly Tyr His Phe Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly 
385                 390                 395                 400 


Lys Ile Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn 
                405                 410                 415     


Leu Thr Asn Met Ile Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser 
            420                 425                 430         


His Ser Thr Tyr Val Phe Leu Met Val Leu Phe Ser Leu Val Leu Phe 
        435                 440                 445             


Thr Val Ala Ile Ile Gly Leu Leu Ile Phe His Lys Pro Ser Tyr Phe 
    450                 455                 460                 


Trp Lys Asp Met Val 
465                 


<210>  9
<211>  1209
<212>  DNA
<213>  Homo sapiens

<400>  9
atggaaagag ctagggaagt gattccaagg tcccagcacc aagagacacc cgtttacctg       60

ggagccacgg caggcatgcg gttgctcagg atggaaagtg aagagttggc agacagggtt      120

ctggatgtgg tggagaggag cctcagcaac tacccctttg acttccaggg tgccaggatc      180

attactggcc aagaggaagg tgcctatggc tggattacta tcaactatct gctgggcaaa      240

ttcagtcaga aaacaaggtg gttcagcata gtcccatatg aaaccaataa tcaggaaacc      300

tttggagctt tggaccttgg gggagcctct acacaagtca cttttgtacc ccaaaaccag      360

actatcgagt ccccagataa tgctctgcaa tttcgcctct atggcaagga ctacaatgtc      420

tacacacata gcttcttgtg ctatgggaag gatcaggcac tctggcagaa actggccaag      480

gacattcagg ttgcaagtaa tgaaattctc agggacccat gctttcatcc tggatataag      540

aaggtagtga acgtaagtga cctttacaag accccctgca ccaagagatt tgagatgact      600

cttccattcc agcagtttga aatccagggt attggaaact atcaacaatg ccatcaaagc      660

atcctggagc tcttcaacac cagttactgc ccttactccc agtgtgcctt caatgggatt      720

ttcttgccac cactccaggg ggattttggg gcattttcag ctttttactt tgtgatgaag      780

tttttaaact tgacatcaga gaaagtctct caggaaaagg tgactgagat gatgaaaaag      840

ttctgtgctc agccttggga ggagataaaa acatcttacg ctggagtaaa ggagaagtac      900

ctgagtgaat actgcttttc tggtacctac attctctccc tccttctgca aggctatcat      960

ttcacagctg attcctggga gcacatccat ttcattggca agatccaggg cagcgacgcc     1020

ggctggactt tgggctacat gctgaacctg accaacatga tcccagctga gcaaccattg     1080

tccacacctc tctcccactc cacctatgtc ttcctcatgg ttctattctc cctggtcctt     1140

ttcacagtgg ccatcatagg cttgcttatc tttcacaagc cttcatattt ctggaaagat     1200

atggtatag                                                             1209


<210>  10
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Glu Arg Ala Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr 
1               5                   10                  15      


Pro Val Tyr Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu 
            20                  25                  30          


Ser Glu Glu Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu 
        35                  40                  45              


Ser Asn Tyr Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln 
    50                  55                  60                  


Glu Glu Gly Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys 
65                  70                  75                  80  


Phe Ser Gln Lys Thr Arg Trp Phe Ser Ile Val Pro Tyr Glu Thr Asn 
                85                  90                  95      


Asn Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln 
            100                 105                 110         


Val Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala 
        115                 120                 125             


Leu Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser 
    130                 135                 140                 


Phe Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys 
145                 150                 155                 160 


Asp Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His 
                165                 170                 175     


Pro Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro 
            180                 185                 190         


Cys Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile 
        195                 200                 205             


Gln Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu 
    210                 215                 220                 


Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile 
225                 230                 235                 240 


Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr 
                245                 250                 255     


Phe Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu 
            260                 265                 270         


Lys Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu 
        275                 280                 285             


Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr 
    290                 295                 300                 


Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His 
305                 310                 315                 320 


Phe Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile Gln 
                325                 330                 335     


Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn 
            340                 345                 350         


Met Ile Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr 
        355                 360                 365             


Tyr Val Phe Leu Met Val Leu Phe Ser Leu Val Leu Phe Thr Val Ala 
    370                 375                 380                 


Ile Ile Gly Leu Leu Ile Phe His Lys Pro Ser Tyr Phe Trp Lys Asp 
385                 390                 395                 400 


Met Val 
        


<210>  11
<211>  1119
<212>  DNA
<213>  Homo sapiens

<400>  11
atggaaagtg aagagttggc agacagggtt ctggatgtgg tggagaggag cctcagcaac       60

tacccctttg acttccaggg tgccaggatc attactggcc aagaggaagg tgcctatggc      120

tggattacta tcaactatct gctgggcaaa ttcagtcaga aaacaaggtg gttcagcata      180

gtcccatatg aaaccaataa tcaggaaacc tttggagctt tggaccttgg gggagcctct      240

acacaagtca cttttgtacc ccaaaaccag actatcgagt ccccagataa tgctctgcaa      300

tttcgcctct atggcaagga ctacaatgtc tacacacata gcttcttgtg ctatgggaag      360

gatcaggcac tctggcagaa actggccaag gacattcagg ttgcaagtaa tgaaattctc      420

agggacccat gctttcatcc tggatataag aaggtagtga acgtaagtga cctttacaag      480

accccctgca ccaagagatt tgagatgact cttccattcc agcagtttga aatccagggt      540

attggaaact atcaacaatg ccatcaaagc atcctggagc tcttcaacac cagttactgc      600

ccttactccc agtgtgcctt caatgggatt ttcttgccac cactccaggg ggattttggg      660

gcattttcag ctttttactt tgtgatgaag tttttaaact tgacatcaga gaaagtctct      720

caggaaaagg tgactgagat gatgaaaaag ttctgtgctc agccttggga ggagataaaa      780

acatcttacg ctggagtaaa ggagaagtac ctgagtgaat actgcttttc tggtacctac      840

attctctccc tccttctgca aggctatcat ttcacagctg attcctggga gcacatccat      900

ttcattggca agatccaggg cagcgacgcc ggctggactt tgggctacat gctgaacctg      960

accaacatga tcccagctga gcaaccattg tccacacctc tctcccactc cacctatgtc     1020

ttcctcatgg ttctattctc cctggtcctt ttcacagtgg ccatcatagg cttgcttatc     1080

tttcacaagc cttcatattt ctggaaagat atggtatag                            1119


<210>  12
<211>  1119
<212>  DNA
<213>  Homo sapiens

<400>  12
atggaaagtg aagagttggc agacagggtt ctggatgtgg tggagaggag cctcagcaac       60

tacccctttg acttccaggg tgccaggatc attactggcc aagaggaagg tgcctatggc      120

tggattacta tcaactatct gctgggcaaa ttcagtcaga aaacaaggtg gttcagcata      180

gtcccatatg aaaccaataa tcaggaaacc tttggagctt tggaccttgg gggagcctct      240

acacaagtca cttttgtacc ccaaaaccag actatcgagt ccccagataa tgctctgcaa      300

tttcgcctct atggcaagga ctacaatgtc tacacacata gcttcttgtg ctatgggaag      360

gatcaggcac tctggcagaa actggccaag gacattcagg ttgcaagtaa tgaaattctc      420

agggacccat gctttcatcc tggatataag aaggtagtga acgtaagtga cctttacaag      480

accccctgca ccaagagatt tgagatgact cttccattcc agcagtttga aatccagggt      540

attggaaact atcaacaatg ccatcaaagc atcctggagc tcttcaacac cagttactgc      600

ccttactccc agtgtgcctt caatgggatt ttcttgccac cactccaggg ggattttggg      660

gcattttcag ctttttactt tgtgatgaag tttttaaact tgacatcaga gaaagtctct      720

caggaaaagg tgactgagat gatgaaaaag ttctgtgctc agccttggga ggagataaaa      780

acatcttacg ctggagtaaa ggagaagtac ctgagtgaat actgcttttc tggtacctac      840

attctctccc tccttctgca aggctatcat ttcacagctg attcctggga gcacatccat      900

ttcattggca agatccaggg cagcgacgcc ggctggactt tgggctacat gctgaacctg      960

accaacatga tcccagctga gcaaccattg tccacacctc tctcccactc cacctatgtc     1020

ttcctcatgg ttctattctc cctggtcctt ttcacagtgg ccatcatagg cttgcttatc     1080

tttcacaagc cttcatattt ctggaaagat atggtatag                            1119


<210>  13
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg 
1               5                   10                  15      


Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr 
            20                  25                  30          


Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu 
        35                  40                  45              


Gly Lys Phe Ser Gln Lys Thr Arg Trp Phe Ser Ile Val Pro Tyr Glu 
    50                  55                  60                  


Thr Asn Asn Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser 
65                  70                  75                  80  


Thr Gln Val Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp 
                85                  90                  95      


Asn Ala Leu Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr 
            100                 105                 110         


His Ser Phe Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu 
        115                 120                 125             


Ala Lys Asp Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys 
    130                 135                 140                 


Phe His Pro Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys 
145                 150                 155                 160 


Thr Pro Cys Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe 
                165                 170                 175     


Glu Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu 
            180                 185                 190         


Glu Leu Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn 
        195                 200                 205             


Gly Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala 
    210                 215                 220                 


Phe Tyr Phe Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser 
225                 230                 235                 240 


Gln Glu Lys Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp 
                245                 250                 255     


Glu Glu Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser 
            260                 265                 270         


Glu Tyr Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly 
        275                 280                 285             


Tyr His Phe Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys 
    290                 295                 300                 


Ile Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu 
305                 310                 315                 320 


Thr Asn Met Ile Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser His 
                325                 330                 335     


Ser Thr Tyr Val Phe Leu Met Val Leu Phe Ser Leu Val Leu Phe Thr 
            340                 345                 350         


Val Ala Ile Ile Gly Leu Leu Ile Phe His Lys Pro Ser Tyr Phe Trp 
        355                 360                 365             


Lys Asp Met Val 
    370         


<210>  14
<211>  1533
<212>  DNA
<213>  Mus musculus

<400>  14
atggaagata taaaggattc taaggtgaag agattttgct ccaaaaatat tctgatcatc       60

cttggtttca cctctatctt ggctgtgata gctttgattg ctgtgggact gacccagaac      120

aaacctttgc cagaaaatgt taagtatggg attgtgttgg atgcggggtc atctcacacc      180

aacctgtaca tctacaagtg gccggccgag aaggagaatg acacaggggt ggtgcagcag      240

ttagaggaat gccaagtgaa aggtcctgga atctcaaaat atgctcagaa aacagatgaa      300

atcggtgcgt acctggccga atgcatggaa ctgtccaccg aactgatacc aacatccaag      360

catcaccaga ctcctgtcta cctgggagcc acagcaggca tgcgcttgct tagaatggaa      420

agcgaacaat cggcagacga ggtcctggct gcagtgtcaa caagccttaa gagctacccc      480

tttgacttcc agggtgccaa gatcatcact ggacaagagg aaggtgccta tgggtggatt      540

actattaact atctgctggg cagattcact caggaacaga gttggctaag cctcatctca      600

gacagtcaga aacaggaaac ctttggcgct ttggatctcg gcggagcctc cacacagatc      660

accttcgtgc cccaaaacag cactatagag tccccagaaa actctctgca attccgtctc      720

tatggcgagg actatactgt gtacacacac agcttcctgt gctatgggaa ggatcaggct      780

ctctggcaga aactggccaa ggacattcag gtttcaagtg gtggcgtcct taaggaccca      840

tgctttaacc caggatacga gaaggttgtg aatgtaagtg agctctatgg cactccctgc      900

accaaaagat tcgaaaagaa gctaccattt gatcagtttc gaatccaggg cactggagac      960

tacgaacagt gccaccagag catccttgag ctcttcaaca acagccactg cccttactcc     1020

cagtgtgcct tcaatggcgt cttcctgcca cctctccatg ggagttttgg ggcgttttct     1080

gctttctact ttgtgatgga tttttttaag aaggtagcga aaaacagtgt catctctcag     1140

gagaaaatga ccgagataac aaaaaatttt tgctcaaaat cttgggaaga gacaaagaca     1200

tcttatcctt cagtaaagga gaagtacctg agtgagtact gcttctcggg cgcctacatc     1260

ctctctctcc tgcaaggcta taacttcaca gacagctcct gggaacagat tcattttatg     1320

ggcaagatca aagacagcaa cgcggggtgg actttgggct acatgctgaa cttgaccaac     1380

atgatcccag ctgaacagcc gttgtccccg cctctccctc actccaccta catcggcctc     1440

atggttctct tctccctgct cttggttgct gtggccatca caggcctgtt catctatagc     1500

aagccttcat atttctggaa agaggcagta tag                                  1533


<210>  15
<211>  510
<212>  PRT
<213>  Mus musculus

<400>  15

Met Glu Asp Ile Lys Asp Ser Lys Val Lys Arg Phe Cys Ser Lys Asn 
1               5                   10                  15      


Ile Leu Ile Ile Leu Gly Phe Thr Ser Ile Leu Ala Val Ile Ala Leu 
            20                  25                  30          


Ile Ala Val Gly Leu Thr Gln Asn Lys Pro Leu Pro Glu Asn Val Lys 
        35                  40                  45              


Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Asn Leu Tyr Ile 
    50                  55                  60                  


Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val Gln Gln 
65                  70                  75                  80  


Leu Glu Glu Cys Gln Val Lys Gly Pro Gly Ile Ser Lys Tyr Ala Gln 
                85                  90                  95      


Lys Thr Asp Glu Ile Gly Ala Tyr Leu Ala Glu Cys Met Glu Leu Ser 
            100                 105                 110         


Thr Glu Leu Ile Pro Thr Ser Lys His His Gln Thr Pro Val Tyr Leu 
        115                 120                 125             


Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Gln Ser 
    130                 135                 140                 


Ala Asp Glu Val Leu Ala Ala Val Ser Thr Ser Leu Lys Ser Tyr Pro 
145                 150                 155                 160 


Phe Asp Phe Gln Gly Ala Lys Ile Ile Thr Gly Gln Glu Glu Gly Ala 
                165                 170                 175     


Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Arg Phe Thr Gln Glu 
            180                 185                 190         


Gln Ser Trp Leu Ser Leu Ile Ser Asp Ser Gln Lys Gln Glu Thr Phe 
        195                 200                 205             


Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Ile Thr Phe Val Pro 
    210                 215                 220                 


Gln Asn Ser Thr Ile Glu Ser Pro Glu Asn Ser Leu Gln Phe Arg Leu 
225                 230                 235                 240 


Tyr Gly Glu Asp Tyr Thr Val Tyr Thr His Ser Phe Leu Cys Tyr Gly 
                245                 250                 255     


Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ser 
            260                 265                 270         


Ser Gly Gly Val Leu Lys Asp Pro Cys Phe Asn Pro Gly Tyr Glu Lys 
        275                 280                 285             


Val Val Asn Val Ser Glu Leu Tyr Gly Thr Pro Cys Thr Lys Arg Phe 
    290                 295                 300                 


Glu Lys Lys Leu Pro Phe Asp Gln Phe Arg Ile Gln Gly Thr Gly Asp 
305                 310                 315                 320 


Tyr Glu Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Asn Ser His 
                325                 330                 335     


Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Val Phe Leu Pro Pro Leu 
            340                 345                 350         


His Gly Ser Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Asp Phe 
        355                 360                 365             


Phe Lys Lys Val Ala Lys Asn Ser Val Ile Ser Gln Glu Lys Met Thr 
    370                 375                 380                 


Glu Ile Thr Lys Asn Phe Cys Ser Lys Ser Trp Glu Glu Thr Lys Thr 
385                 390                 395                 400 


Ser Tyr Pro Ser Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser 
                405                 410                 415     


Gly Ala Tyr Ile Leu Ser Leu Leu Gln Gly Tyr Asn Phe Thr Asp Ser 
            420                 425                 430         


Ser Trp Glu Gln Ile His Phe Met Gly Lys Ile Lys Asp Ser Asn Ala 
        435                 440                 445             


Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala 
    450                 455                 460                 


Glu Gln Pro Leu Ser Pro Pro Leu Pro His Ser Thr Tyr Ile Gly Leu 
465                 470                 475                 480 


Met Val Leu Phe Ser Leu Leu Leu Val Ala Val Ala Ile Thr Gly Leu 
                485                 490                 495     


Phe Ile Tyr Ser Lys Pro Ser Tyr Phe Trp Lys Glu Ala Val 
            500                 505                 510 


<210>  16
<211>  1536
<212>  DNA
<213>  Rattus norvegicus

<400>  16
atggaagata taaaggattc taaggtgaag agattttgct ccaaaaatat tctgatcatc       60

cttggtttct cctctgtctt ggctgtgata gctttgattg ctgtgggact gacccacaac      120

aaaccattgc cagaaaatgt taagtatggg attgtgctgg atgccgggtc gtctcacacc      180

aacctgtaca tctacaagtg gccggctgag aaggagaatg atacaggagt ggtgcagctg      240

ttagaagaat gccaagtgaa aggtcccgga atctcaaaat acgctcagaa aacagatgaa      300

atagctgcat atctggctga atgcatgaaa atgtccactg agcggatacc agcgtccaaa      360

cagcaccaga cacccgtgta cctgggagcc accgcgggca tgcgcttgct cagaatggaa      420

agcaagcaat cggcagacga agtcctggct gcagtgtcta ggagcctgaa gagctacccc      480

tttgacttcc agggcgccaa gatcatcact gggcaggagg aaggggccta tgggtggatt      540

actattaact atctgctggg cagattcact caggaacaga gttggctaaa cttcatctca      600

gacagccaga aacaggcaac ctttggcgct ttggatcttg gcggcagttc tacacaagtc      660

accttcgtgc ccctaaatca gactctagag gccccagaaa cctccctgca gttccgtctc      720

tacggcacgg actacaccgt gtacacacac agcttcctgt gctatgggaa ggatcaggca      780

ctctggcaga aactggccca ggacattcag gtttcaagtg gtgggattct caaggacccg      840

tgcttttacc caggatataa gaaggttgtg aatgtaagcg aactctatgg cactccctgc      900

accaagagat ttgagaagaa gctaccgttt aatcagtttc aagttcaggg cactggagat      960

tacgaacagt gccaccagag catcctcaag ttcttcaaca acagccactg cccttactcc     1020

cagtgtgcct tcaacggtgt ctttttacca cctctccagg ggagttttgg ggcattttct     1080

gctttctact ttgtgatgga cttttttaag aagatggcga acgacagtgt ctcctctcag     1140

gagaaaatga ctgagataac aaaaaacttt tgctcaaagc cttgggagga ggtaaaggca     1200

tcttatccta cagtaaagga gaagtacctg agtgaatact gtttctcggg gacctacatc     1260

ctgtctctcc ttctgcaagg ctataacttc acgggaacct cctgggacca gattcatttt     1320

atgggcaaga tcaaagacag caacgcaggg tggactttgg gctacatgct gaacttgacc     1380

aacatgatcc cagctgaaca gccattatcc ccgcctctcc ctcactccac ctacatcagc     1440

ctcatggttc tcttctccct ggtcttggtc gccatggtca tcacagggct gttcatcttt     1500

agcaagcctt cgtatttctg gaaagaggca gtatag                               1536


<210>  17
<211>  511
<212>  PRT
<213>  Rattus norvegicus

<400>  17

Met Glu Asp Ile Lys Asp Ser Lys Val Lys Arg Phe Cys Ser Lys Asn 
1               5                   10                  15      


Ile Leu Ile Ile Leu Gly Phe Ser Ser Val Leu Ala Val Ile Ala Leu 
            20                  25                  30          


Ile Ala Val Gly Leu Thr His Asn Lys Pro Leu Pro Glu Asn Val Lys 
        35                  40                  45              


Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Asn Leu Tyr Ile 
    50                  55                  60                  


Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val Gln Leu 
65                  70                  75                  80  


Leu Glu Glu Cys Gln Val Lys Gly Pro Gly Ile Ser Lys Tyr Ala Gln 
                85                  90                  95      


Lys Thr Asp Glu Ile Ala Ala Tyr Leu Ala Glu Cys Met Lys Met Ser 
            100                 105                 110         


Thr Glu Arg Ile Pro Ala Ser Lys Gln His Gln Thr Pro Val Tyr Leu 
        115                 120                 125             


Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Lys Gln Ser 
    130                 135                 140                 


Ala Asp Glu Val Leu Ala Ala Val Ser Arg Ser Leu Lys Ser Tyr Pro 
145                 150                 155                 160 


Phe Asp Phe Gln Gly Ala Lys Ile Ile Thr Gly Gln Glu Glu Gly Ala 
                165                 170                 175     


Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Arg Phe Thr Gln Glu 
            180                 185                 190         


Gln Ser Trp Leu Asn Phe Ile Ser Asp Ser Gln Lys Gln Ala Thr Phe 
        195                 200                 205             


Gly Ala Leu Asp Leu Gly Gly Ser Ser Thr Gln Val Thr Phe Val Pro 
    210                 215                 220                 


Leu Asn Gln Thr Leu Glu Ala Pro Glu Thr Ser Leu Gln Phe Arg Leu 
225                 230                 235                 240 


Tyr Gly Thr Asp Tyr Thr Val Tyr Thr His Ser Phe Leu Cys Tyr Gly 
                245                 250                 255     


Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Gln Asp Ile Gln Val Ser 
            260                 265                 270         


Ser Gly Gly Ile Leu Lys Asp Pro Cys Phe Tyr Pro Gly Tyr Lys Lys 
        275                 280                 285             


Val Val Asn Val Ser Glu Leu Tyr Gly Thr Pro Cys Thr Lys Arg Phe 
    290                 295                 300                 


Glu Lys Lys Leu Pro Phe Asn Gln Phe Gln Val Gln Gly Thr Gly Asp 
305                 310                 315                 320 


Tyr Glu Gln Cys His Gln Ser Ile Leu Lys Phe Phe Asn Asn Ser His 
                325                 330                 335     


Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Val Phe Leu Pro Pro Leu 
            340                 345                 350         


Gln Gly Ser Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Asp Phe 
        355                 360                 365             


Phe Lys Lys Met Ala Asn Asp Ser Val Ser Ser Gln Glu Lys Met Thr 
    370                 375                 380                 


Glu Ile Thr Lys Asn Phe Cys Ser Lys Pro Trp Glu Glu Val Lys Ala 
385                 390                 395                 400 


Ser Tyr Pro Thr Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser 
                405                 410                 415     


Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr Asn Phe Thr Gly 
            420                 425                 430         


Thr Ser Trp Asp Gln Ile His Phe Met Gly Lys Ile Lys Asp Ser Asn 
        435                 440                 445             


Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro 
    450                 455                 460                 


Ala Glu Gln Pro Leu Ser Pro Pro Leu Pro His Ser Thr Tyr Ile Ser 
465                 470                 475                 480 


Leu Met Val Leu Phe Ser Leu Val Leu Val Ala Met Val Ile Thr Gly 
                485                 490                 495     


Leu Phe Ile Phe Ser Lys Pro Ser Tyr Phe Trp Lys Glu Ala Val 
            500                 505                 510     


<210>  18
<211>  1542
<212>  DNA
<213>  Bos taurus

<400>  18
atggaagata gaagggaatc tgaactgaag gtattttgct ctaaaaacat actgagcata       60

cttggtttct cctgcatcat cgctgtgata gcattgctcg ctctggggct gacccagaac      120

aaagcactgc cagaaaatgt taagtttggg attgtgctgg atgcgggctc ctctcatacg      180

agtttgtaca tctatagatg gccggcagag aaggagaatg acacgggggt ggtgactcag      240

atagaagaat cgaacgttaa aggtcccgga atctcaggct ttgctaaaaa agtaaatgaa      300

atcaatgttt atctgacggc atgcatggaa agagcccaga aagtgattcc gtcaatccag      360

cacatggaaa cacctgtgta cctgggagcc acggccggca tgcggttgct ccggatggaa      420

aataaacaga tggcagacaa gatcctggct gcagttgcaa gcagcatcag cgagtacccc      480

tttgacttcc aaggtgccag aatcatcagt ggccaggagg aaggtgccta tggctggatt      540

actgtcaact atttgctggg caaattcact cagaaattga gttggtttaa cctgaagcca      600

agcaaagacg acactcagga aacctatgga gctttagacc ttgggggagc ctctacacaa      660

atcacttttg tgccccaaaa tgaaacgacc gagtctccaa acaacaacct gtacttccgc      720

ctctatggca agaactacag tgtatacaca cacagcttcc tgtgctatgg gaaggaccaa      780

gcacttttgc agaaactggc cctgggactt cagggtacaa atggaatcat ccatgagcca      840

tgctttcact caagatacat gaggaaaata aagatgagcg tcttaaacga aggtttctgt      900

accaagagac atgagttgaa ttcttcattt tatccactcg ttgacattga aatccgtggc      960

gctggaaact tccaacgatg tcggcaaagc atcattcaac tctttaacac cagttactgc     1020

ccttactcca gttgctcctt caatggggtt ttcttgccgc cactccatgg gcagtttggg     1080

gcattttcag ctttttacta tgtgatggag tttttaaacc ttacatcaga ggaatcagta     1140

tctgtggaac agttgactga gaagttggaa gagttctgcg cacagcgttg ggaagaggtg     1200

cagaagaatt ttggtgaagt gaaggagaaa tacctgagtg aatactgctt ttctggcacc     1260

tacatcctgg ttctcctcct gaatggctac cattttacag ctgagtcctg gaaaaatatt     1320

cacttcatga acaaggtccg gagcaccgac gttgggtgga ctttgggcta catgctgaac     1380

ctgaccaaca agattccagc tgaagagcca atgtccccac ccctccccca ctccacctat     1440

gtcttcctca tggtcctctt ctccctgatc ctgctcgcag tgatcatcgt aggcatagtt     1500

gtctttcaca agccttcgta tttctggaaa gacatggtat ag                        1542


<210>  19
<211>  513
<212>  PRT
<213>  Bos taurus

<400>  19

Met Glu Asp Arg Arg Glu Ser Glu Leu Lys Val Phe Cys Ser Lys Asn 
1               5                   10                  15      


Ile Leu Ser Ile Leu Gly Phe Ser Cys Ile Ile Ala Val Ile Ala Leu 
            20                  25                  30          


Leu Ala Leu Gly Leu Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys 
        35                  40                  45              


Phe Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile 
    50                  55                  60                  


Tyr Arg Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val Thr Gln 
65                  70                  75                  80  


Ile Glu Glu Ser Asn Val Lys Gly Pro Gly Ile Ser Gly Phe Ala Lys 
                85                  90                  95      


Lys Val Asn Glu Ile Asn Val Tyr Leu Thr Ala Cys Met Glu Arg Ala 
            100                 105                 110         


Gln Lys Val Ile Pro Ser Ile Gln His Met Glu Thr Pro Val Tyr Leu 
        115                 120                 125             


Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Asn Lys Gln Met 
    130                 135                 140                 


Ala Asp Lys Ile Leu Ala Ala Val Ala Ser Ser Ile Ser Glu Tyr Pro 
145                 150                 155                 160 


Phe Asp Phe Gln Gly Ala Arg Ile Ile Ser Gly Gln Glu Glu Gly Ala 
                165                 170                 175     


Tyr Gly Trp Ile Thr Val Asn Tyr Leu Leu Gly Lys Phe Thr Gln Lys 
            180                 185                 190         


Leu Ser Trp Phe Asn Leu Lys Pro Ser Lys Asp Asp Thr Gln Glu Thr 
        195                 200                 205             


Tyr Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Ile Thr Phe Val 
    210                 215                 220                 


Pro Gln Asn Glu Thr Thr Glu Ser Pro Asn Asn Asn Leu Tyr Phe Arg 
225                 230                 235                 240 


Leu Tyr Gly Lys Asn Tyr Ser Val Tyr Thr His Ser Phe Leu Cys Tyr 
                245                 250                 255     


Gly Lys Asp Gln Ala Leu Leu Gln Lys Leu Ala Leu Gly Leu Gln Gly 
            260                 265                 270         


Thr Asn Gly Ile Ile His Glu Pro Cys Phe His Ser Arg Tyr Met Arg 
        275                 280                 285             


Lys Ile Lys Met Ser Val Leu Asn Glu Gly Phe Cys Thr Lys Arg His 
    290                 295                 300                 


Glu Leu Asn Ser Ser Phe Tyr Pro Leu Val Asp Ile Glu Ile Arg Gly 
305                 310                 315                 320 


Ala Gly Asn Phe Gln Arg Cys Arg Gln Ser Ile Ile Gln Leu Phe Asn 
                325                 330                 335     


Thr Ser Tyr Cys Pro Tyr Ser Ser Cys Ser Phe Asn Gly Val Phe Leu 
            340                 345                 350         


Pro Pro Leu His Gly Gln Phe Gly Ala Phe Ser Ala Phe Tyr Tyr Val 
        355                 360                 365             


Met Glu Phe Leu Asn Leu Thr Ser Glu Glu Ser Val Ser Val Glu Gln 
    370                 375                 380                 


Leu Thr Glu Lys Leu Glu Glu Phe Cys Ala Gln Arg Trp Glu Glu Val 
385                 390                 395                 400 


Gln Lys Asn Phe Gly Glu Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys 
                405                 410                 415     


Phe Ser Gly Thr Tyr Ile Leu Val Leu Leu Leu Asn Gly Tyr His Phe 
            420                 425                 430         


Thr Ala Glu Ser Trp Lys Asn Ile His Phe Met Asn Lys Val Arg Ser 
        435                 440                 445             


Thr Asp Val Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Lys 
    450                 455                 460                 


Ile Pro Ala Glu Glu Pro Met Ser Pro Pro Leu Pro His Ser Thr Tyr 
465                 470                 475                 480 


Val Phe Leu Met Val Leu Phe Ser Leu Ile Leu Leu Ala Val Ile Ile 
                485                 490                 495     


Val Gly Ile Val Val Phe His Lys Pro Ser Tyr Phe Trp Lys Asp Met 
            500                 505                 510         


Val 
    


<210>  20
<211>  1527
<212>  DNA
<213>  Xenopus laevis

<400>  20
atggacgaac caaaggctgc aaaacagaag aagacatggc acaaaaaagt cataatcttc       60

ctaggagctc tgtttgtctt gggtgttatc tctttagtcg caattgcagt agtgcagaat      120

aaacctcttc caaagaatat taagtatggc attgtgctgg acgctggttc gtcccatacc      180

agtgtgtata tatatgaatg gccggcagaa aaggaaaatg acaccggtgt tgtacagcag      240

ataaacgagt gcaaagttga aggcaacggt atatccagtt atggccacga gccactgaag      300

gccggtcttt ctctacagaa gtgtatgaat aaagcccgtc aggtcattcc tgagaagcag      360

caaagggaga caccagttta tttaggggcc acagcaggaa tgcgtttgct caggctaact      420

aatgcaacaa tggctgagga agtcctgtct tcagtggaaa atacgctgcg ttcctttccg      480

tttgattttc agggtgccag aataattaca ggacaagaag aaggcgctta tggatggatc      540

acaattaatt atctgcttgg aaactttatc caggattcag gttggttcaa atatatacca      600

aatttcaaac ccactgaaac ttccggtgca ctggatcttg gaggtgcttc aacacagatc      660

acctttgagt ccaaaagaga gattgaatcc caagaaaatt ccttgcactt ccgcctttat      720

ggtaaatcct atgatatcta tacacacagc tttctctgct atggaaagga ccaagctctg      780

cgccttcaga tagctaatag tataaaggat gcaacagatt ccatcctttt ggatccttgc      840

tttaactcag gatatagaag gaacgcaagc accaatgacc tctacagtag tccctgcata      900

tctaaactga ggataccaac agcacccagc accttagata ttagaggcac tggcaattat      960

cagctatgca agagaaatgt ccaggcaatc ttcaacagaa cacattgtac ttactcacat     1020

tgctctttta atggggtttt tcaaccaagt ttggatggca catttggggc attctcagca     1080

tattattttg ttatgaattt tttaaacctt accaatgagc aaatgtctct tgacaaagta     1140

aaagagacgg tagaaagaca ctgctccaga ccatgggacg aggtaaaaaa agactttcca     1200

aaaattaaag aaaaatacct gagtgaatac tgtttttctg gaacatatat attaaatctt     1260

cttgaatatg gatacggctt tagctctgaa aactggaacg atatcagatt tttaggcaag     1320

atcaaagaca gtgatgcagg atggacactt ggttatatgc tgaacctgac caatatgatc     1380

cctgcagagc tgccttattc tcctccgctg tcccacgctg gttacactgg acttatggtc     1440

ttcttctcca ttttgttagt ctgcattatt ttgacttgct ggctgagttt ccggaaacca     1500

aaatgtctac acaagggcat catctag                                         1527


<210>  21
<211>  508
<212>  PRT
<213>  Xenopus laevis

<400>  21

Met Asp Glu Pro Lys Ala Ala Lys Gln Lys Lys Thr Trp His Lys Lys 
1               5                   10                  15      


Val Ile Ile Phe Leu Gly Ala Leu Phe Val Leu Gly Val Ile Ser Leu 
            20                  25                  30          


Val Ala Ile Ala Val Val Gln Asn Lys Pro Leu Pro Lys Asn Ile Lys 
        35                  40                  45              


Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Val Tyr Ile 
    50                  55                  60                  


Tyr Glu Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val Gln Gln 
65                  70                  75                  80  


Ile Asn Glu Cys Lys Val Glu Gly Asn Gly Ile Ser Ser Tyr Gly His 
                85                  90                  95      


Glu Pro Leu Lys Ala Gly Leu Ser Leu Gln Lys Cys Met Asn Lys Ala 
            100                 105                 110         


Arg Gln Val Ile Pro Glu Lys Gln Gln Arg Glu Thr Pro Val Tyr Leu 
        115                 120                 125             


Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Leu Thr Asn Ala Thr Met 
    130                 135                 140                 


Ala Glu Glu Val Leu Ser Ser Val Glu Asn Thr Leu Arg Ser Phe Pro 
145                 150                 155                 160 


Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala 
                165                 170                 175     


Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Asn Phe Ile Gln Asp 
            180                 185                 190         


Ser Gly Trp Phe Lys Tyr Ile Pro Asn Phe Lys Pro Thr Glu Thr Ser 
        195                 200                 205             


Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Ile Thr Phe Glu Ser 
    210                 215                 220                 


Lys Arg Glu Ile Glu Ser Gln Glu Asn Ser Leu His Phe Arg Leu Tyr 
225                 230                 235                 240 


Gly Lys Ser Tyr Asp Ile Tyr Thr His Ser Phe Leu Cys Tyr Gly Lys 
                245                 250                 255     


Asp Gln Ala Leu Arg Leu Gln Ile Ala Asn Ser Ile Lys Asp Ala Thr 
            260                 265                 270         


Asp Ser Ile Leu Leu Asp Pro Cys Phe Asn Ser Gly Tyr Arg Arg Asn 
        275                 280                 285             


Ala Ser Thr Asn Asp Leu Tyr Ser Ser Pro Cys Ile Ser Lys Leu Arg 
    290                 295                 300                 


Ile Pro Thr Ala Pro Ser Thr Leu Asp Ile Arg Gly Thr Gly Asn Tyr 
305                 310                 315                 320 


Gln Leu Cys Lys Arg Asn Val Gln Ala Ile Phe Asn Arg Thr His Cys 
                325                 330                 335     


Thr Tyr Ser His Cys Ser Phe Asn Gly Val Phe Gln Pro Ser Leu Asp 
            340                 345                 350         


Gly Thr Phe Gly Ala Phe Ser Ala Tyr Tyr Phe Val Met Asn Phe Leu 
        355                 360                 365             


Asn Leu Thr Asn Glu Gln Met Ser Leu Asp Lys Val Lys Glu Thr Val 
    370                 375                 380                 


Glu Arg His Cys Ser Arg Pro Trp Asp Glu Val Lys Lys Asp Phe Pro 
385                 390                 395                 400 


Lys Ile Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr Tyr 
                405                 410                 415     


Ile Leu Asn Leu Leu Glu Tyr Gly Tyr Gly Phe Ser Ser Glu Asn Trp 
            420                 425                 430         


Asn Asp Ile Arg Phe Leu Gly Lys Ile Lys Asp Ser Asp Ala Gly Trp 
        435                 440                 445             


Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu Leu 
    450                 455                 460                 


Pro Tyr Ser Pro Pro Leu Ser His Ala Gly Tyr Thr Gly Leu Met Val 
465                 470                 475                 480 


Phe Phe Ser Ile Leu Leu Val Cys Ile Ile Leu Thr Cys Trp Leu Ser 
                485                 490                 495     


Phe Arg Lys Pro Lys Cys Leu His Lys Gly Ile Ile 
            500                 505             


<210>  22
<211>  1479
<212>  DNA
<213>  Danio rerio

<400>  22
atggaagtaa aagtcaaaaa cccatggcac aggccggttg tcatctttct gatggctgtt       60

gttgccgtgg ggattgtcat catggtatcc atttctgttg tccagcacaa gcctttaccc      120

caaaagtaca agtatggaat agtcctggat gccggctcct ctcacacctc tgtgtttatc      180

tataaatggc cagcagagaa agagaacaac acaggcatgg tacagcagca tcacacgtgc      240

aatgttaaag gcaaaggcat ctccagttac ttcgataaac cacatggggc tggtgcatct      300

ctggaggagt gcatgaagga ggccaaggag aaaatacctg ctcacagaca cagcgaaacc      360

cctgtctacc tgggagccac ggctggcatg agactgctca agatggagga tgaaatggcc      420

tcagaaaaag tgcttacctc cgttgcacat tcactgaaga cgtacccctt ctcctatcag      480

ggagctcgta tcctttcagg ccaagaggag ggagcttttg ggtggattac agtcaactac      540

cttagtgaaa acttgagaaa gcccgcaggc actcttggag ctctggacct tggtggagcc      600

tctactcaaa taaccttcgt acctcagcag attattgaat catctgacaa ttcgattgac      660

ttcagactgt atggaaatga ttatcatcta tacacccaca gctttctctg ttatgggaag      720

gaccaagctc tcaagcttgc tatggctgag aaattgcgct caacacctga caagacagat      780

gccattttgt taagggatcc ttgttttcat cctggatata acaccaccaa gacgcttgaa      840

agtgtcaata caccatgtat gaaaccactg aaaatgccaa aggagcagtt ctcccatgtg      900

gggcttggaa attggtctca gtgccaagaa tcaatcagaa aggtttttaa tactagccat      960

tgtccttatt caggctgctc attcaatggt gttttccaac ctactgttga aggaaaattt     1020

ggggcttttt ctgctttctt ttttgtaatg gactttttaa atctgaaaaa cgattcattg     1080

gacaaaacaa agcagaggct ggcaatgtac tgctctaccc catggcaaaa gattgtacaa     1140

gatcacccaa aagtaaaaga gaagtacctt tctgaatact gcttctcagc aacatacatt     1200

ctcactctcc tggaacatgg atacaatttc acctcagaca actggaacga catcaagttt     1260

atcaagaaga ttggagacag tgatgcaggc tggactttag gttacatgct taacctgacc     1320

aacatgattc cggctgaaga tccagacaag ccactgatgc ctcatggagg atacgtcaca     1380

tttatgatcc tcttctcact tttgatactc gtcctcatca ttatggccta catttatttc     1440

cgtcgcttta ctaaaacagc ccagaaagac attatttag                            1479


<210>  23
<211>  492
<212>  PRT
<213>  Danio rerio

<400>  23

Met Glu Val Lys Val Lys Asn Pro Trp His Arg Pro Val Val Ile Phe 
1               5                   10                  15      


Leu Met Ala Val Val Ala Val Gly Ile Val Ile Met Val Ser Ile Ser 
            20                  25                  30          


Val Val Gln His Lys Pro Leu Pro Gln Lys Tyr Lys Tyr Gly Ile Val 
        35                  40                  45              


Leu Asp Ala Gly Ser Ser His Thr Ser Val Phe Ile Tyr Lys Trp Pro 
    50                  55                  60                  


Ala Glu Lys Glu Asn Asn Thr Gly Met Val Gln Gln His His Thr Cys 
65                  70                  75                  80  


Asn Val Lys Gly Lys Gly Ile Ser Ser Tyr Phe Asp Lys Pro His Gly 
                85                  90                  95      


Ala Gly Ala Ser Leu Glu Glu Cys Met Lys Glu Ala Lys Glu Lys Ile 
            100                 105                 110         


Pro Ala His Arg His Ser Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala 
        115                 120                 125             


Gly Met Arg Leu Leu Lys Met Glu Asp Glu Met Ala Ser Glu Lys Val 
    130                 135                 140                 


Leu Thr Ser Val Ala His Ser Leu Lys Thr Tyr Pro Phe Ser Tyr Gln 
145                 150                 155                 160 


Gly Ala Arg Ile Leu Ser Gly Gln Glu Glu Gly Ala Phe Gly Trp Ile 
                165                 170                 175     


Thr Val Asn Tyr Leu Ser Glu Asn Leu Arg Lys Pro Ala Gly Thr Leu 
            180                 185                 190         


Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Ile Thr Phe Val Pro 
        195                 200                 205             


Gln Gln Ile Ile Glu Ser Ser Asp Asn Ser Ile Asp Phe Arg Leu Tyr 
    210                 215                 220                 


Gly Asn Asp Tyr His Leu Tyr Thr His Ser Phe Leu Cys Tyr Gly Lys 
225                 230                 235                 240 


Asp Gln Ala Leu Lys Leu Ala Met Ala Glu Lys Leu Arg Ser Thr Pro 
                245                 250                 255     


Asp Lys Thr Asp Ala Ile Leu Leu Arg Asp Pro Cys Phe His Pro Gly 
            260                 265                 270         


Tyr Asn Thr Thr Lys Thr Leu Glu Ser Val Asn Thr Pro Cys Met Lys 
        275                 280                 285             


Pro Leu Lys Met Pro Lys Glu Gln Phe Ser His Val Gly Leu Gly Asn 
    290                 295                 300                 


Trp Ser Gln Cys Gln Glu Ser Ile Arg Lys Val Phe Asn Thr Ser His 
305                 310                 315                 320 


Cys Pro Tyr Ser Gly Cys Ser Phe Asn Gly Val Phe Gln Pro Thr Val 
                325                 330                 335     


Glu Gly Lys Phe Gly Ala Phe Ser Ala Phe Phe Phe Val Met Asp Phe 
            340                 345                 350         


Leu Asn Leu Lys Asn Asp Ser Leu Asp Lys Thr Lys Gln Arg Leu Ala 
        355                 360                 365             


Met Tyr Cys Ser Thr Pro Trp Gln Lys Ile Val Gln Asp His Pro Lys 
    370                 375                 380                 


Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Ala Thr Tyr Ile 
385                 390                 395                 400 


Leu Thr Leu Leu Glu His Gly Tyr Asn Phe Thr Ser Asp Asn Trp Asn 
                405                 410                 415     


Asp Ile Lys Phe Ile Lys Lys Ile Gly Asp Ser Asp Ala Gly Trp Thr 
            420                 425                 430         


Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu Asp Pro 
        435                 440                 445             


Asp Lys Pro Leu Met Pro His Gly Gly Tyr Val Thr Phe Met Ile Leu 
    450                 455                 460                 


Phe Ser Leu Leu Ile Leu Val Leu Ile Ile Met Ala Tyr Ile Tyr Phe 
465                 470                 475                 480 


Arg Arg Phe Thr Lys Thr Ala Gln Lys Asp Ile Ile 
                485                 490         


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: HLA Class I tetramer 
       peptide"

<400>  24

Gly Ile Asp Pro Asn Ile Arg Thr Gly Val 
1               5                   10  


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: HLA Class I tetramer 
       peptide"

<400>  25

Lys Leu Val Ala Leu Gly Ile Asn Ala Val 
1               5                   10  


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: HLA Class I tetramer 
       peptide"

<400>  26

Ala Thr Asp Ala Leu Met Thr Gly Tyr 
1               5                   


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: HLA Class I tetramer 
       peptide"

<400>  27

Arg Glu Ile Ser Val Pro Ala Glu Ile Leu 
1               5                   10  


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: HLA Class I tetramer 
       peptide"

<400>  28

Gly Pro Arg Leu Gly Val Arg Ala Thr 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: HLA Class I tetramer 
       peptide"

<400>  29

Val Leu Ser Asp Phe Lys Thr Trp Leu 
1               5                   


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: HLA Class I tetramer 
       peptide"

<400>  30

Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
1               5                   10  


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: HLA Class I tetramer 
       peptide"

<400>  31

Ala Arg Met Ile Leu Met Thr His Phe 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: HLA Class I tetramer 
       peptide"

<400>  32

Cys Ile Asn Gly Val Cys Trp Thr Val 
1               5                   


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: HLA Class I tetramer 
       peptide"

<400>  33

Asn Leu Val Pro Met Val Ala Thr Cys 
1               5                   


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: HLA Class I tetramer 
       peptide"

<400>  34

Gly Leu Cys Thr Leu Val Ala Met Leu 
1               5                   


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: HLA Class I tetramer 
       peptide"

<400>  35

Arg Tyr Pro Leu Thr Phe Gly Trp 
1               5               


<210>  36
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: HLA Class I tetramer 
       peptide"

<400>  36

Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe 
1               5                   10      


<210>  37
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: HLA Class I tetramer 
       peptide"

<400>  37

Asp Arg Phe Tyr Lys Thr Leu Arg Ala 
1               5                   


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: HLA Class I tetramer 
       peptide"

<400>  38

His Pro Val His Ala Gly Pro Ile Ala 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: HLA Class I tetramer 
       peptide"

<400>  39

Asp Arg Phe Tyr Lys Thr Leu Arg Ala 
1               5                   


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: HLA Class I tetramer 
       peptide"

<400>  40

Ser Leu Tyr Asn Thr Val Ala Thr Leu 
1               5                   


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: HLA Class I tetramer 
       peptide"

<400>  41

Thr Pro Gln Asp Leu Asn Thr Met Leu 
1               5                   


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: HLA Class I tetramer 
       peptide"

<400>  42

Ser Leu Tyr Asn Thr Val Ala Thr Leu 
1               5                   


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: HLA Class I tetramer 
       peptide"

<400>  43

Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe 
1               5                   10      


<210>  44
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: HLA Class I tetramer 
       peptide"

<400>  44

Glu Ile Tyr Lys Arg Trp Ile Ile 
1               5               


<210>  45
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: HLA Class I tetramer 
       peptide"

<400>  45

Val Pro Leu Arg Pro Met Thr Tyr 
1               5               


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: HLA Class I tetramer 
       peptide"

<400>  46

Gly Pro Gly His Lys Ala Arg Val Leu 
1               5                   


<210>  47
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: HLA Class I tetramer 
       peptide"

<400>  47

Ser Gly Val Glu Asn Pro Gly Gly Tyr Cys Leu 
1               5                   10