
                                SEQUENCE LISTING

<110> Thomas-Tikhonenko, Andrei
      Grupp, Stephan
      Maris, John
      Barrett, David
      Sotillo-Pineiro, Elena

<120> Compositions and Methods for Treating
  B-Lymphoid Malignancies
  

<130> 3460-P06104WO00

<140> PCT/US2015/055764   
<141> 2015-10-15  

<150> 62/064,131          
<151> 2014-10-15  

<160> 80

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 244
<212> DNA
<213> Artificial Sequence

<220> 
<223> DNA Fragment EcoRI/BglII CD19-ex2

<400> 1
gaattcacca ccatgccacc tcctcgcctc ctcttcttcc tcctcttcct cacccccatg 60
gaagtcaggc ccgaggaacc tctagtggtg aaggtggaag aggagctgtt ccggtggaat 120
gtttcggacc taggtggcct gggctgtggc ctgaagaaca ggtcctcaga gggccccagc 180
tccccttccg ggaagctcat gagccccaag ctgtatgtgt gggccaaaga ccgccctgag 240
atct                                                              244

<210> 2
<211> 1049
<212> DNA
<213> Artificial Sequence

<220> 
<223> DNA Fragment BglII/XhoI CD19-ex5-6

<400> 2
agatctggga gggagagcct ccgtgtctcc caccgaggga cagcctgaac cagagcctca 60
gccaggacct caccatggcc cctggctcca cactctggct gtcctgtggg gtaccccctg 120
actctgtgtc caggggcccc ctctcctgga cccatgtgca ccccaagggg cctaagtcat 180
tgctgagcct agagctgaag gacgatcgcc cggccagaga tatgtgggta atggagacgg 240
gtctgttgtt gccccgggcc acagctcaag acgctggaaa gtattattgt caccgtggca 300
acctgaccat gtcattccac ctggagatca ctgctcggcc agattcttca aagtgacgcc 360
tcccccagga agcgggcccc agaaccagta cgggaacgtg ctgtctctcc ccacacccac 420
ctcaggcctc ggacgcgccc agcgttgggc cgcaggcctg gggggcactg ccccgtctta 480
tggaaacccg agcagcgacg tccaggcgga tggagccttg gggtcccgga gcccgccggg 540
agtgggccca gaagaagagg aaggggaggg ctatgaggaa cctgacagtg aggaggactc 600
cgagttctat gagaacgact ccaaccttgg gcaggaccag ctctcccagg atggcagcgg 660
ctacgagaac cctgaggatg agcccctggg tcctgaggat gaagactcct tctccaacgc 720
tgagtcttat gagaacgagg atgaagagct gacccagccg gtcgccagga caatggactt 780
cctgagccct catgggtcag cctgggaccc cagccgggaa gcaacctccc tggggtccca 840
gtcctatgag gatatgagag gaatcctgta tgcagccccc cagctccgct ccattcgggg 900
ccagcctgga cccaatcatg aggaagatgc agactcttat gagaacatgg ataatcccga 960
tgggccagac ccagcctggg gaggaggggg ccgcatgggc acctggagca ccaggtgatc 1020
ctcaggtggc cagcctggat ctcctcgag                                   1049

<210> 3
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 3
gcaggggaat gacatgctct                                             20

<210> 4
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 4
attagcccag tgtccagcac                                             20

<210> 5
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 5
atgatgtgct ggacactggg                                             20

<210> 6
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 6
tccctgccac gctgttttat                                             20

<210> 7
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 7
tctactccaa ggggctcaca                                             20

<210> 8
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 8
actgcagcac agcgttatct                                             20

<210> 9
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 9
ggagagtctg accaccatgc                                             20

<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 10
ggacacagag tcagggggta                                             20

<210> 11
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 11
gagccccaag ctgtatgtgt                                             20

<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 12
gaagttgggg tttggggtga                                             20

<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 13
ttccctcgct tccaagacac                                             20

<210> 14
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 14
gggattgtca cagaccctgg                                             20

<210> 15
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 15
tgccagggtc tgtgacaatc                                             20

<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 16
aggctagagg aagactgggg                                             20

<210> 17
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 17
ccccagtctt cctctagcct                                             20

<210> 18
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 18
gaagaggaag tgcacggtga                                             20

<210> 19
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 19
aatgactgac cccaccagga                                             20

<210> 20
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 20
tgctcgggtt tccataagac                                             20

<210> 21
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 21
gaacttcgcc ccagaactga                                             20

<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 22
aagctgcaga gtaagctggg                                             20

<210> 23
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 23
cagccgggaa gcaacct                                                17

<210> 24
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 24
attgctccag aggttggcat                                             20

<210> 25
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 25
aatttttgtt tttaaaggat ttttt                                       25

<210> 26
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 26
ctacaaataa caaaacctcc acttc                                       25

<210> 27
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 27
ttgggttttt ttaaaataat ttttttt                                     27

<210> 28
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 28
aacaaaaacc aaacacaata atacac                                      26

<210> 29
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 29
agttttattt tggtgtttag gttgg                                       25

<210> 30
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 30
aaacacataa actccttctc aaaaa                                       25

<210> 31
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 31
tttgtgtaga aaatagaaat gaataaataa                                  30

<210> 32
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 32
aacaaaaacc taaaaaacac tcaac                                       25

<210> 33
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 33
gtagatattt atggttgagt gttttttagg                                  30

<210> 34
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 34
ttcctaaatt ttacaaataa aaaaataaaa                                  30

<210> 35
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 35
ggtttttatt agattttggg gtttt                                       25

<210> 36
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 36
taatatctct acaaccttcc ccaac                                       25

<210> 37
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 37
ccgaggaacc tctagtggtg aagg                                        24

<210> 38
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 38
ccacaggaca gccagagtgt gga                                         23

<210> 39
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 39
cctaagtcat tgctgagcct agagc                                       25

<210> 40
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 40
cgctgctcgg gtttccataa gacg                                        24

<210> 41
<211> 749
<212> DNA
<213> Artificial Sequence

<220> 
<223> XhoI/NotI CD19-int1-ex2-int2

<400> 41
ctcgaggaag ggattgaggc tggaaacttg agttgtggct gggtgtcctt ggctgagtaa 60
cttaccctct ctgagcctcc attttcttat ttgtaaaatt caggaaaggg ttggaaggac 120
tctgccggct cctccactcc cagcttttgg agtcctctgc tctataacct ggtgtgagga 180
gtcggggggc ttggaggtcc cccccaccca tgcccacacc tctctccctc tctctccaca 240
gagggagata acgctgtgct gcagtgcctc aaggggacct cagatggccc cactcagcag 300
ctgacctggt ctcgggagtc cccgcttaaa cccttcttaa aactcagcct ggggctgcca 360
ggcctgggaa tccacatgag gcccctggcc atctggcttt tcatcttcaa cgtctctcaa 420
cagatggggg gcttctacct gtgccagccg gggcccccct ctgagaaggc ctggcagcct 480
ggctggacag tcaatgtgga gggcagcggt gagggccggg ctggggcagg ggcaggagga 540
gagaagggag gccaccatgg acagaagagg tccgcggcca caatggagct ggagagaggg 600
gctggaggga ttgagggcga aactcggagc taggtgggca gactcctggg gcttcgtggc 660
ttcagtatga gctgcttcct gtccctctac ctctcactgt cttctctctc tctgcgggtc 720
tttgtctcta tttatctctg tgcggccgc                                   749

<210> 42
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 42
ggagagtctg accaccatgc                                             20

<210> 43
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 43
ggacacagag tcagggggta                                             20

<210> 44
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 44
aaggggccta agtcattgct                                             20

<210> 45
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 45
tgctcgggtt tccataagac                                             20

<210> 46
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 46
ggcccgagga acctcta                                                17

<210> 47
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 47
cagcagccag tgccatagta                                             20

<210> 48
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 48
cacccggctt tgcttttgtt                                             20

<210> 49
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 49
cggcagccac atagtgttct                                             20

<210> 50
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 50
cggagccgca gcccta                                                 16

<210> 51
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 51
ggtcgaccga gatcgagaac                                             20

<210> 52
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 52
agaacccggg agtaggagac                                             20

<210> 53
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 53
agccgaaaat gtagctgaag a                                           21

<210> 54
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 54
ggtaggctgg cagatacgtt                                             20

<210> 55
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 55
taacgatgct tcttcggcgg                                             20

<210> 56
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 56
agcatccccc aaagttcac                                              19

<210> 57
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 57
aagggacttc ctgtaacaac g                                           21

<210> 58
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 58
ggagagtctg accaccatgc                                             20

<210> 59
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 59
actgcagcac agcgttatct                                             20

<210> 60
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 60
gagccccaag ctgtatgtgt                                             20

<210> 61
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 61
ggacacagag tcagggggta                                             20

<210> 62
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 62
gcctcctctt cttcctcctc tt                                          22

<210> 63
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 63
ccggaacagc tccccttcca ccttc                                       25

<210> 64
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 64
aaggggccta agtcattgct                                             20

<210> 65
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 65
cagcagccag tgccatagta                                             20

<210> 66
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 66
ccccaccagg agattcttca                                             20

<210> 67
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 67
tgctcgggtt tccataagac                                             20

<210> 68
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 68
tagtggtgaa ggtggaaggg gagctgttcc ggtg                             34

<210> 69
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 69
actcagcctg gggctgccag ggctggg                                     27

<210> 70
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 70
ctcggccagt actatggc                                               18

<210> 71
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 71
ctcggccaga ttcttcaa                                               18

<210> 72
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 72
gagggcagcg gggagctg                                               18

<210> 73
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 73
aaggtggaag gggagctg                                               18

<210> 74
<211> 266
<212> DNA
<213> Artificial Sequence

<220> 
<223> CD19-exon2

<400> 74
agggagataa cgctgtgctg cagtgcctca aggggacctc agatggcccc actcagcagc 60
tgacctggtc tcgggagtcc ccgcttaaac ccttcttaaa actcagcctg gggctgccag 120
gcctgggaat ccacatgagg cccctggcca tctggctttt catcttcaac gtctctcaac 180
agatgggggg cttctacctg tgccagccgg ggcccccctc tgagaaggcc tggcagcctg 240
gctggacagt caatgtggag ggcagc                                      266

<210> 75
<211> 11
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 75
tggggctgcc a                                                      11

<210> 76
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 76
tggcccctcc ggacagt                                                17

<210> 77
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 77
ccgggccccc ct                                                     12

<210> 78
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 78
cccctccgg                                                         9

<210> 79
<211> 1965
<212> DNA
<213> Homo sapiens

<400> 79
aggcccctgc ctgccccagc atcccctgcg cgaagctggg tgccccggag agtctgacca 60
ccatgccacc tcctcgcctc ctcttcttcc tcctcttcct cacccccatg gaagtcaggc 120
ccgaggaacc tctagtggtg aaggtggaag agggagataa cgctgtgctg cagtgcctca 180
aggggacctc agatggcccc actcagcagc tgacctggtc tcgggagtcc ccgcttaaac 240
ccttcttaaa actcagcctg gggctgccag gcctgggaat ccacatgagg cccctggcca 300
tctggctttt catcttcaac gtctctcaac agatgggggg cttctacctg tgccagccgg 360
ggcccccctc tgagaaggcc tggcagcctg gctggacagt caatgtggag ggcagcgggg 420
agctgttccg gtggaatgtt tcggacctag gtggcctggg ctgtggcctg aagaacaggt 480
cctcagaggg ccccagctcc ccttccggga agctcatgag ccccaagctg tatgtgtggg 540
ccaaagaccg ccctgagatc tgggagggag agcctccgtg tctcccaccg agggacagcc 600
tgaaccagag cctcagccag gacctcacca tggcccctgg ctccacactc tggctgtcct 660
gtggggtacc ccctgactct gtgtccaggg gccccctctc ctggacccat gtgcacccca 720
aggggcctaa gtcattgctg agcctagagc tgaaggacga tcgcccggcc agagatatgt 780
gggtaatgga gacgggtctg ttgttgcccc gggccacagc tcaagacgct ggaaagtatt 840
attgtcaccg tggcaacctg accatgtcat tccacctgga gatcactgct cggccagtac 900
tatggcactg gctgctgagg actggtggct ggaaggtctc agctgtgact ttggcttatc 960
tgatcttctg cctgtgttcc cttgtgggca ttcttcatct tcaaagagcc ctggtcctga 1020
ggaggaaaag aaagcgaatg actgacccca ccaggagatt cttcaaagtg acgcctcccc 1080
caggaagcgg gccccagaac cagtacggga acgtgctgtc tctccccaca cccacctcag 1140
gcctcggacg cgcccagcgt tgggccgcag gcctgggggg cactgccccg tcttatggaa 1200
acccgagcag cgacgtccag gcggatggag ccttggggtc ccggagcccg ccgggagtgg 1260
gcccagaaga agaggaaggg gagggctatg aggaacctga cagtgaggag gactccgagt 1320
tctatgagaa cgactccaac cttgggcagg accagctctc ccaggatggc agcggctacg 1380
agaaccctga ggatgagccc ctgggtcctg aggatgaaga ctccttctcc aacgctgagt 1440
cttatgagaa cgaggatgaa gagctgaccc agccggtcgc caggacaatg gacttcctga 1500
gccctcatgg gtcagcctgg gaccccagcc gggaagcaac ctccctgggg tcccagtcct 1560
atgaggatat gagaggaatc ctgtatgcag ccccccagct ccgctccatt cggggccagc 1620
ctggacccaa tcatgaggaa gatgcagact cttatgagaa catggataat cccgatgggc 1680
cagacccagc ctggggagga gggggccgca tgggcacctg gagcaccagg tgatcctcag 1740
gtggccagcc tggatctcct caagtcccca agattcacac ctgactctga aatctgaaga 1800
cctcgagcag atgatgccaa cctctggagc aatgttgctt aggatgtgtg catgtgtgta 1860
agtgtgtgtg tgtgtgtgtg tgtgtataca tgccagtgac acttccagtc ccctttgtat 1920
tccttaaata aactcaatga gctcttccaa tcctaaaaaa aaaaa                 1965

<210> 80
<211> 556
<212> PRT
<213> Homo Sapiens

<400> 80
Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met
 1               5                  10                  15      
Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp
            20                  25                  30          
Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln
        35                  40                  45              
Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu
    50                  55                  60                  
Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile
65                  70                  75                  80  
Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu
                85                  90                  95      
Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr
            100                 105                 110         
Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp
        115                 120                 125             
Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro
    130                 135                 140                 
Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala
145                 150                 155                 160 
Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro
                165                 170                 175     
Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro
            180                 185                 190         
Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser
        195                 200                 205             
Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser
    210                 215                 220                 
Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp
225                 230                 235                 240 
Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala
                245                 250                 255     
Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu
            260                 265                 270         
Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly
        275                 280                 285             
Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu
    290                 295                 300                 
Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg
305                 310                 315                 320 
Arg Lys Arg Lys Arg Met Thr Asp Pro Thr Arg Arg Phe Phe Lys Val
                325                 330                 335     
Thr Pro Pro Pro Gly Ser Gly Pro Gln Asn Gln Tyr Gly Asn Val Leu
            340                 345                 350         
Ser Leu Pro Thr Pro Thr Ser Gly Leu Gly Arg Ala Gln Arg Trp Ala
        355                 360                 365             
Ala Gly Leu Gly Gly Thr Ala Pro Ser Tyr Gly Asn Pro Ser Ser Asp
    370                 375                 380                 
Val Gln Ala Asp Gly Ala Leu Gly Ser Arg Ser Pro Pro Gly Val Gly
385                 390                 395                 400 
Pro Glu Glu Glu Glu Gly Glu Gly Tyr Glu Glu Pro Asp Ser Glu Glu
                405                 410                 415     
Asp Ser Glu Phe Tyr Glu Asn Asp Ser Asn Leu Gly Gln Asp Gln Leu
            420                 425                 430         
Ser Gln Asp Gly Ser Gly Tyr Glu Asn Pro Glu Asp Glu Pro Leu Gly
        435                 440                 445             
Pro Glu Asp Glu Asp Ser Phe Ser Asn Ala Glu Ser Tyr Glu Asn Glu
    450                 455                 460                 
Asp Glu Glu Leu Thr Gln Pro Val Ala Arg Thr Met Asp Phe Leu Ser
465                 470                 475                 480 
Pro His Gly Ser Ala Trp Asp Pro Ser Arg Glu Ala Thr Ser Leu Gly
                485                 490                 495     
Ser Gln Ser Tyr Glu Asp Met Arg Gly Ile Leu Tyr Ala Ala Pro Gln
            500                 505                 510         
Leu Arg Ser Ile Arg Gly Gln Pro Gly Pro Asn His Glu Glu Asp Ala
        515                 520                 525             
Asp Ser Tyr Glu Asn Met Asp Asn Pro Asp Gly Pro Asp Pro Ala Trp
    530                 535                 540                 
Gly Gly Gly Gly Arg Met Gly Thr Trp Ser Thr Arg
545                 550                 555     

