                         SEQUENCE LISTING

<110>  DECIPHERA PHARMACEUTICALS, LLC
       FLYNN, Daniel L.
       KAUFMAN, Michael D.
       SMITH, Bryan D.
 
<120>  INHIBITION OF TUMOR CELL INTERACTIONS WITH THE MICROENVIRONMENT 
       RESULTING IN A REDUCTION IN TUMOR GROWTH AND DISEASE PROGRESSION

<130>  DECP-068/01WO

<150>  US 62/603,656
<151>  2014-10-14

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Leu Lys Arg Ala Asn Val Gln Arg Arg Met Ala Gln Ala Phe Gln 
1               5                   10                  15      


Asn Val Arg Glu Glu Pro Ala Val Gln Phe Asn Ser Gly Thr Leu Ala 
            20                  25                  30          


Leu Asn Arg Lys Val Lys Asn Asn Pro Asp Pro Thr Ile Tyr Pro Val 
        35                  40                  45              


Leu Asp Trp Asn Asp Ile Lys Phe Gln Asp Val Ile Gly Glu Gly Asn 
    50                  55                  60                  


Phe Gly Gln Val Leu Lys Ala Arg Ile Lys Lys Asp Gly Leu Arg Met 
65                  70                  75                  80  


Asp Ala Ala Ile Lys Arg Met Lys Glu Tyr Ala Ser Lys Asp Asp His 
                85                  90                  95      


Arg Asp Phe Ala Gly Glu Leu Glu Val Leu Cys Lys Leu Gly His His 
            100                 105                 110         


Pro Asn Ile Ile Asn Leu Leu Gly Ala Cys Glu His Arg Gly Tyr Leu 
        115                 120                 125             


Tyr Leu Ala Ile Glu Tyr Ala Pro His Gly Asn Leu Leu Asp Phe Leu 
    130                 135                 140                 


Arg Lys Ser Arg Val Leu Glu Thr Asp Pro Ala Phe Ala Ile Ala Asn 
145                 150                 155                 160 


Ser Thr Ala Ser Thr Leu Ser Ser Gln Gln Leu Leu His Phe Ala Ala 
                165                 170                 175     


Asp Val Ala Arg Gly Met Asp Tyr Leu Ser Gln Lys Gln Phe Ile His 
            180                 185                 190         


Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Gly Glu Asn Tyr Val Ala 
        195                 200                 205             


Lys Ile Ala Asp Phe Gly Leu Ser Arg Gly Gln Glu Val Tyr Val Lys 
    210                 215                 220                 


Lys Thr Met Gly Arg Leu Pro Val Arg Trp Met Ala Ile Glu Ser Leu 
225                 230                 235                 240 


Asn Tyr Ser Val Tyr Thr Thr Asn Ser Asp Val Trp Ser Tyr Gly Val 
                245                 250                 255     


Leu Leu Trp Glu Ile Val Ser Leu Gly Gly Thr Pro Tyr Cys Gly Met 
            260                 265                 270         


Thr Cys Ala Glu Leu Tyr Glu Lys Leu Pro Gln Gly Tyr Arg Leu Glu 
        275                 280                 285             


Lys Pro Leu Asn Cys Asp Asp Glu Val Tyr Asp Leu Met Arg Gln Cys 
    290                 295                 300                 


Trp Arg Glu Lys Pro Tyr Glu Arg Pro Ser Phe Ala Gln Ile Leu Val 
305                 310                 315                 320 


Ser Leu Asn Arg Met Leu Glu Glu Arg Lys Thr Tyr Val Asn Thr Thr 
                325                 330                 335     


Leu Tyr Glu Lys Phe Thr Tyr Ala Gly Ile Asp Cys Ser Ala Glu Glu 
            340                 345                 350         


Ala Ala 
        


<210>  2
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  2

Thr Val His Ile Asp Leu Ser Ala Leu Asn Pro Glu Leu Val Gln Ala 
1               5                   10                  15      


Val Gln His Val Val Ile Gly Pro Ser Ser Leu Ile Val His Phe Asn 
            20                  25                  30          


Glu Val Ile Gly Arg Gly His Phe Gly Cys Val Tyr His Gly Thr Leu 
        35                  40                  45              


Leu Asp Asn Asp Gly Lys Lys Ile His Cys Ala Val Lys Ser Leu Asn 
    50                  55                  60                  


Arg Ile Thr Asp Ile Gly Glu Val Ser Gln Phe Leu Thr Glu Gly Ile 
65                  70                  75                  80  


Ile Met Lys Asp Phe Ser His Pro Asn Val Leu Ser Leu Leu Gly Ile 
                85                  90                  95      


Cys Leu Arg Ser Glu Gly Ser Pro Leu Val Val Leu Pro Tyr Met Lys 
            100                 105                 110         


His Gly Asp Leu Arg Asn Phe Ile Arg Asn Glu Thr His Asn Pro Thr 
        115                 120                 125             


Val Lys Asp Leu Ile Gly Phe Gly Leu Gln Val Ala Lys Gly Met Lys 
    130                 135                 140                 


Tyr Leu Ala Ser Lys Lys Phe Val His Arg Asp Leu Ala Ala Arg Asn 
145                 150                 155                 160 


Cys Met Leu Asp Glu Lys Phe Thr Val Lys Val Ala Asp Phe Gly Leu 
                165                 170                 175     


Ala Arg Asp Met Tyr Asp Lys Glu Tyr Tyr Ser Val His Asn Lys Thr 
            180                 185                 190         


Gly Ala Lys Leu Pro Val Lys Trp Met Ala Leu Glu Ser Leu Gln Thr 
        195                 200                 205             


Gln Lys Phe Thr Thr Lys Ser Asp Val Trp Ser Phe Gly Val Leu Leu 
    210                 215                 220                 


Trp Glu Leu Met Thr Arg Gly Ala Pro Pro Tyr Pro Asp Val Asn Thr 
225                 230                 235                 240 


Phe Asp Ile Thr Val Tyr Leu Leu Gln Gly Arg Arg Leu Leu Gln Pro 
                245                 250                 255     


Glu Tyr Cys Pro Asp Pro Leu Tyr Glu Val Met Leu Lys Cys Trp His 
            260                 265                 270         


Pro Lys Ala Glu Met Arg Pro Ser Phe Ser Glu Leu Val Ser Arg Ile 
        275                 280                 285             


Ser Ala Ile Phe Ser Thr Phe Ile Gly Glu His Tyr Val His Val Asn 
    290                 295                 300                 


Ala Thr Tyr Val Asn Val Lys 
305                 310     


<210>  3
<211>  315
<212>  PRT
<213>  Homo sapiens

<400>  3

Asp Pro Asp Glu Leu Pro Leu Asp Glu His Cys Glu Arg Leu Pro Tyr 
1               5                   10                  15      


Asp Ala Ser Lys Trp Glu Phe Pro Arg Asp Arg Leu Lys Leu Gly Lys 
            20                  25                  30          


Pro Leu Gly Arg Gly Ala Phe Gly Gln Val Ile Glu Ala Asp Ala Phe 
        35                  40                  45              


Gly Ile Asp Lys Thr Ala Thr Cys Arg Thr Val Ala Val Lys Met Leu 
    50                  55                  60                  


Lys Glu Gly Ala Thr His Ser Glu His Arg Ala Leu Met Ser Glu Leu 
65                  70                  75                  80  


Lys Ile Leu Ile His Ile Gly His His Leu Asn Val Val Asn Leu Leu 
                85                  90                  95      


Gly Ala Cys Thr Lys Pro Gly Gly Pro Leu Met Val Ile Val Glu Phe 
            100                 105                 110         


Cys Lys Phe Gly Asn Leu Ser Thr Tyr Leu Arg Ser Lys Arg Asn Glu 
        115                 120                 125             


Phe Val Pro Tyr Lys Val Ala Pro Glu Asp Leu Tyr Lys Asp Phe Leu 
    130                 135                 140                 


Thr Leu Glu His Leu Ile Cys Tyr Ser Phe Gln Val Ala Lys Gly Met 
145                 150                 155                 160 


Glu Phe Leu Ala Ser Arg Lys Cys Ile His Arg Asp Leu Ala Ala Arg 
                165                 170                 175     


Asn Ile Leu Leu Ser Glu Lys Asn Val Val Lys Ile Cys Asp Phe Gly 
            180                 185                 190         


Leu Ala Arg Asp Ile Tyr Lys Asp Pro Asp Tyr Val Arg Lys Gly Asp 
        195                 200                 205             


Ala Arg Leu Pro Leu Lys Trp Met Ala Pro Glu Thr Ile Phe Asp Arg 
    210                 215                 220                 


Val Tyr Thr Ile Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp 
225                 230                 235                 240 


Glu Ile Phe Ser Leu Gly Ala Ser Pro Tyr Pro Gly Val Lys Ile Asp 
                245                 250                 255     


Glu Glu Phe Cys Arg Arg Leu Lys Glu Gly Thr Arg Met Arg Ala Pro 
            260                 265                 270         


Asp Tyr Thr Thr Pro Glu Met Tyr Gln Thr Met Leu Asp Cys Trp His 
        275                 280                 285             


Gly Glu Pro Ser Gln Arg Pro Thr Phe Ser Glu Leu Val Glu His Leu 
    290                 295                 300                 


Gly Asn Leu Leu Gln Ala Asn Ala Gln Gln Asp 
305                 310                 315 


