                         SEQUENCE LISTING

<110>  Flynn, Daniel L.
       Kaufman, Michael
       Smith, Bryan
 
<120>  INHIBITION OF TRK KINASE MEDIATED TUMOR GROWTH AND DISEASE 
       PROGRESSION

<130>  DECP-067/01WO

<150>  US 62/063,660
<151>  2014-10-14

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Lys Cys Gly Arg Arg Asn Lys Phe Gly Ile Asn Arg Pro Ala Val 
1               5                   10                  15      


Leu Ala Pro Glu Asp Gly Leu Ala Met Ser Leu His Phe Met Thr Leu 
            20                  25                  30          


Gly Gly Ser Ser Leu Ser Pro Thr Glu Gly Lys Gly Ser Gly Leu Gln 
        35                  40                  45              


Gly His Ile Ile Glu Asn Pro Gln Tyr Phe Ser Asp Ala Cys Val His 
    50                  55                  60                  


His Ile Lys Arg Arg Asp Ile Val Leu Lys Trp Glu Leu Gly Glu Gly 
65                  70                  75                  80  


Ala Phe Gly Lys Val Phe Leu Ala Glu Cys His Asn Leu Leu Pro Glu 
                85                  90                  95      


Gln Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys Glu Ala Ser Glu 
            100                 105                 110         


Ser Ala Arg Gln Asp Phe Gln Arg Glu Ala Glu Leu Leu Thr Met Leu 
        115                 120                 125             


Gln His Gln His Ile Val Arg Phe Phe Gly Val Cys Thr Glu Gly Arg 
    130                 135                 140                 


Pro Leu Leu Met Val Phe Glu Tyr Met Arg His Gly Asp Leu Asn Arg 
145                 150                 155                 160 


Phe Leu Arg Ser His Gly Pro Asp Ala Lys Leu Leu Ala Gly Gly Glu 
                165                 170                 175     


Asp Val Ala Pro Gly Pro Leu Gly Leu Gly Gln Leu Leu Ala Val Ala 
            180                 185                 190         


Ser Gln Val Ala Ala Gly Met Val Tyr Leu Ala Gly Leu His Phe Val 
        195                 200                 205             


His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Gln Gly Leu Val 
    210                 215                 220                 


Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Ile Tyr Ser Thr Asp 
225                 230                 235                 240 


Tyr Tyr Arg Val Gly Gly Arg Thr Met Leu Pro Ile Arg Trp Met Pro 
                245                 250                 255     


Pro Glu Ser Ile Leu Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val Trp 
            260                 265                 270         


Ser Phe Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln Pro 
        275                 280                 285             


Trp Tyr Gln Leu Ser Asn Thr Glu Ala Ile Asp Cys Ile Thr Gln Gly 
    290                 295                 300                 


Arg Glu Leu Glu Arg Pro Arg Ala Cys Pro Pro Glu Val Tyr Ala Ile 
305                 310                 315                 320 


Met Arg Gly Cys Trp Gln Arg Glu Pro Gln Gln Arg His Ser Ile Lys 
                325                 330                 335     


Asp Val His Ala Arg Leu Gln Ala Leu Ala Gln Ala Pro Pro Val Tyr 
            340                 345                 350         


Leu Asp Val Leu Gly Lys Gly Val Glu Ala Cys Gln Leu Gly Thr Asp 
        355                 360                 365             


Asp Tyr Asp Ile Pro Thr Thr His His His His His His 
    370                 375                 380     


<210>  2
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Ile Glu Asn Pro Gln Tyr Phe Gly Ile Thr Asn Ser Gln Leu 
1               5                   10                  15      


Lys Pro Asp Thr Phe Val Gln His Ile Lys Arg His Asn Ile Val Leu 
            20                  25                  30          


Lys Arg Glu Leu Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu 
        35                  40                  45              


Cys Tyr Asn Leu Cys Pro Glu Gln Asp Lys Ile Leu Val Ala Val Lys 
    50                  55                  60                  


Thr Leu Lys Asp Ala Ser Asp Asn Ala Arg Lys Asp Phe His Arg Glu 
65                  70                  75                  80  


Ala Glu Leu Leu Thr Asn Leu Gln His Glu His Ile Val Lys Phe Tyr 
                85                  90                  95      


Gly Val Cys Val Glu Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met 
            100                 105                 110         


Lys His Gly Asp Leu Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala 
        115                 120                 125             


Val Leu Met Ala Glu Gly Asn Pro Pro Thr Glu Leu Thr Gln Ser Gln 
    130                 135                 140                 


Met Leu His Ile Ala Gln Gln Ile Ala Ala Gly Met Val Tyr Leu Ala 
145                 150                 155                 160 


Ser Gln His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val 
                165                 170                 175     


Gly Glu Asn Leu Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp 
            180                 185                 190         


Val Tyr Ser Thr Asp Tyr Tyr Arg Val Gly Gly His Thr Met Leu Pro 
        195                 200                 205             


Ile Arg Trp Met Pro Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr 
    210                 215                 220                 


Glu Ser Asp Val Trp Ser Leu Gly Val Val Leu Trp Glu Ile Phe Thr 
225                 230                 235                 240 


Tyr Gly Lys Gln Pro Trp Tyr Gln Leu Ser Asn Asn Glu Val Ile Glu 
                245                 250                 255     


Cys Ile Thr Gln Gly Arg Val Leu Gln Arg Pro Arg Thr Cys Pro Gln 
            260                 265                 270         


Glu Val Tyr Glu Leu Met Leu Gly Cys Trp Gln Arg Glu Pro His Met 
        275                 280                 285             


Arg Lys Asn Ile Lys Gly Ile His Thr Leu Leu Gln Asn Leu Ala Lys 
    290                 295                 300                 


Ala Ser Pro Val Tyr Leu Asp Ile Leu Gly Lys Gly Gly Arg Ala Asp 
305                 310                 315                 320 


Pro Ala Phe Leu Tyr Lys Val Val Arg Met Asn Glu Asp Leu Gly Lys 
                325                 330                 335     


Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Arg Thr Gly His 
            340                 345                 350         


His His His His His 
        355         


<210>  3
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Val Ile Glu Asn Pro Gln Tyr Phe Arg Gln Gly His Asn Cys His 
1               5                   10                  15      


Lys Pro Asp Thr Tyr Val Gln His Ile Lys Arg Arg Asp Ile Val Leu 
            20                  25                  30          


Lys Arg Glu Leu Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu 
        35                  40                  45              


Cys Tyr Asn Leu Ser Pro Thr Lys Asp Lys Met Leu Val Ala Val Lys 
    50                  55                  60                  


Ala Leu Lys Asp Pro Thr Leu Ala Ala Arg Lys Asp Phe Gln Arg Glu 
65                  70                  75                  80  


Ala Glu Leu Leu Thr Asn Leu Gln His Glu His Ile Val Lys Phe Tyr 
                85                  90                  95      


Gly Val Cys Gly Asp Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met 
            100                 105                 110         


Lys His Gly Asp Leu Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala 
        115                 120                 125             


Met Ile Leu Val Asp Gly Gln Pro Arg Gln Ala Lys Gly Glu Leu Gly 
    130                 135                 140                 


Leu Ser Gln Met Leu His Ile Ala Ser Gln Ile Ala Ser Gly Met Val 
145                 150                 155                 160 


Tyr Leu Ala Ser Gln His Phe Val His Arg Asp Leu Ala Thr Arg Asn 
                165                 170                 175     


Cys Leu Val Gly Ala Asn Leu Leu Val Lys Ile Gly Asp Phe Gly Met 
            180                 185                 190         


Ser Arg Asp Val Tyr Ser Thr Asp Tyr Tyr Arg Val Gly Gly His Thr 
        195                 200                 205             


Met Leu Pro Ile Arg Trp Met Pro Pro Glu Ser Ile Met Tyr Arg Lys 
    210                 215                 220                 


Phe Thr Thr Glu Ser Asp Val Trp Ser Phe Gly Val Ile Leu Trp Glu 
225                 230                 235                 240 


Ile Phe Thr Tyr Gly Lys Gln Pro Trp Phe Gln Leu Ser Asn Thr Glu 
                245                 250                 255     


Val Ile Glu Cys Ile Thr Gln Gly Arg Val Leu Glu Arg Pro Arg Val 
            260                 265                 270         


Cys Pro Lys Glu Val Tyr Asp Val Met Leu Gly Cys Trp Gln Arg Glu 
        275                 280                 285             


Pro Gln Gln Arg Leu Asn Ile Lys Glu Ile Tyr Lys Ile Leu His Ala 
    290                 295                 300                 


Leu Gly Lys Ala Thr Pro Ile Tyr Leu Asp Ile Leu Gly Lys Gly Gly 
305                 310                 315                 320 


Arg Ala Asp Pro Ala Phe Leu Tyr Lys Val Val Arg Met Asn Glu Asp 
                325                 330                 335     


Leu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Arg 
            340                 345                 350         


Thr Gly His His His His His His 
        355                 360 


