                         SEQUENCE LISTING

<110>  Pioneer HiBred International
       Abad, Andre
       Dong, Hua
       Kapka-Kitzman, Deirdre
       Lo, Sue
       Shi, Xiaomei
       Wolfe, Thomas
       Zhou, Lan
 
<120>  INSECTICIDAL POLYPEPTIDES HAVING BROAD SPECTRUM ACTIVITY AND USES
        THEREOF

<130>  4803-WO-PCT

<150>  US 62/064712
<151>  2014-10-16

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  2112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized variant

<400>  1
atgggaggaa aaagtatgaa tcgaaataat caaggtgaat atgaaattat tgacgcttcc       60

acttgtggtt gttcgtcaga tgatgttgtt caatatcctt tggcaagaga tccgaatgct      120

gcattccaaa atatgaatta taaagattat ttgaaaatgt ctgacggaga ctacgtcgat      180

tcttatataa acccaggctt atctattggt cgtagagatg tgaccctaac tggagttggt      240

attgttgcgc taatagtagg gactttaggt ggtccagttg ggggtatagt aactggcttg      300

atttcctctc ttttaggatt attgtggcca agtaatgata atgatgtatg ggaagcattt      360

atggcacaaa tagaagagct aattgaacaa aggatagcag atcaagtagt aaggaatgca      420

ctcgataact taactggatt gcgcgattat tataatcaat acctattagc attggaggag      480

tggcaggaaa ggccgaacgc tgtaagatct accttagttt ttaatagatt tgaaaccctg      540

cattctcact ttgtaactag tatgccaagt tttggtagtg gccctggaag tgaaaggtat      600

gcggtacaat tgctgacagt ttatgcacaa gcggcaaatc tgcatttgtt attattaaga      660

gatgctgaca tttatggggc aaggtgggga cttcgtgaat ctcagattga tttatatttt      720

aatgagctac aaaatcgtac tcgtgattat accaatcatt gtgtaactgc gtacaataat      780

gggttagagg agatacgagg aacaagccct gcaagttggt tgaggtacca tcaattccgt      840

agagagacaa cactaatagc attggattta gtggcgatat tcccatatta caacgtacga      900

gaatatccaa ttggggtaaa tcctcagctt acacgtgatg tatatacaga tccaataggg      960

gttactttca gaagagaaga ttgggaaaca ggagtagaat gcagaccatg ggtaaatact     1020

ccttacatga gcttttcgga tcttgaaaat gcaataattc gtccaccaca tctatttgaa     1080

acattacgta atttaacaat tcatacaggt cgatataacc tagtaggagg ggcgagattt     1140

attgaaggat gggtcggaca ttctgtaaca aatactcgct tgggtaattc aacagtattt     1200

acaagtaatt atggttcttt gccacctcgt tttcaagttt ttaattttac taattttgat     1260

gtttaccaaa ttaatacgag agcagattct acaggtacct ttagaatccc tggatttgca     1320

gttacaaggg cccaattcat tccgggtggg acttattcag tagctcaccg agatccaggg     1380

gcatgtcaac aagattatga ttcaattgaa gagttaccaa gtctagaccc ggatgaacct     1440

attaatagaa gttatagtca tagattatcg catgttaccc tttataaata tactctctca     1500

gatacagatt atggagttat caattataca gattatggaa gtatgcctgc atatgtctgg     1560

acacatcgcg atgtggacct tactaacacg attactgcag atagaattac acaactccca     1620

ttagtaaagg catctacact acctgcgggt actactgtgg taaaaggccc aggatttaca     1680

ggaggagata tactccgaag aacaactaat ggaacatttg ggacattaca tgtaagggtt     1740

aattcaccat taacacaaca atatcgccta agagttcgtt ttgcctcaac aggaaatttc     1800

agtataaggg tactccgtgg agggacttct atcggtgatg ctagatttgg gagcacaatg     1860

aacagaggac aggaactaac ttacgaatcc tttgtcacaa gagagtttac tactactggt     1920

ccgttcaatc cgccttttac atttacacaa actcaagaaa ttctaacagt gaatgcagaa     1980

ggtgttagca ccggtggtga atattatata gatagtattg agattgttcc tgtaaatccg     2040

acgcgagagg cggaagagga tctagaagca gcgaagaaag cggtggcgag cttgtttaca     2100

cgtacaaggt aa                                                         2112


<210>  2
<211>  703
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of MP311FL

<400>  2

Met Gly Gly Lys Ser Met Asn Arg Asn Asn Gln Gly Glu Tyr Glu Ile 
1               5                   10                  15      


Ile Asp Ala Ser Thr Cys Gly Cys Ser Ser Asp Asp Val Val Gln Tyr 
            20                  25                  30          


Pro Leu Ala Arg Asp Pro Asn Ala Ala Phe Gln Asn Met Asn Tyr Lys 
        35                  40                  45              


Asp Tyr Leu Lys Met Ser Asp Gly Asp Tyr Val Asp Ser Tyr Ile Asn 
    50                  55                  60                  


Pro Gly Leu Ser Ile Gly Arg Arg Asp Val Thr Leu Thr Gly Val Gly 
65                  70                  75                  80  


Ile Val Ala Leu Ile Val Gly Thr Leu Gly Gly Pro Val Gly Gly Ile 
                85                  90                  95      


Val Thr Gly Leu Ile Ser Ser Leu Leu Gly Leu Leu Trp Pro Ser Asn 
            100                 105                 110         


Asp Asn Asp Val Trp Glu Ala Phe Met Ala Gln Ile Glu Glu Leu Ile 
        115                 120                 125             


Glu Gln Arg Ile Ala Asp Gln Val Val Arg Asn Ala Leu Asp Asn Leu 
    130                 135                 140                 


Thr Gly Leu Arg Asp Tyr Tyr Asn Gln Tyr Leu Leu Ala Leu Glu Glu 
145                 150                 155                 160 


Trp Gln Glu Arg Pro Asn Ala Val Arg Ser Thr Leu Val Phe Asn Arg 
                165                 170                 175     


Phe Glu Thr Leu His Ser His Phe Val Thr Ser Met Pro Ser Phe Gly 
            180                 185                 190         


Ser Gly Pro Gly Ser Glu Arg Tyr Ala Val Gln Leu Leu Thr Val Tyr 
        195                 200                 205             


Ala Gln Ala Ala Asn Leu His Leu Leu Leu Leu Arg Asp Ala Asp Ile 
    210                 215                 220                 


Tyr Gly Ala Arg Trp Gly Leu Arg Glu Ser Gln Ile Asp Leu Tyr Phe 
225                 230                 235                 240 


Asn Glu Leu Gln Asn Arg Thr Arg Asp Tyr Thr Asn His Cys Val Thr 
                245                 250                 255     


Ala Tyr Asn Asn Gly Leu Glu Glu Ile Arg Gly Thr Ser Pro Ala Ser 
            260                 265                 270         


Trp Leu Arg Tyr His Gln Phe Arg Arg Glu Thr Thr Leu Ile Ala Leu 
        275                 280                 285             


Asp Leu Val Ala Ile Phe Pro Tyr Tyr Asn Val Arg Glu Tyr Pro Ile 
    290                 295                 300                 


Gly Val Asn Pro Gln Leu Thr Arg Asp Val Tyr Thr Asp Pro Ile Gly 
305                 310                 315                 320 


Val Thr Phe Arg Arg Glu Asp Trp Glu Thr Gly Val Glu Cys Arg Pro 
                325                 330                 335     


Trp Val Asn Thr Pro Tyr Met Ser Phe Ser Asp Leu Glu Asn Ala Ile 
            340                 345                 350         


Ile Arg Pro Pro His Leu Phe Glu Thr Leu Arg Asn Leu Thr Ile His 
        355                 360                 365             


Thr Gly Arg Tyr Asn Leu Val Gly Gly Ala Arg Phe Ile Glu Gly Trp 
    370                 375                 380                 


Val Gly His Ser Val Thr Asn Thr Arg Leu Gly Asn Ser Thr Val Phe 
385                 390                 395                 400 


Thr Ser Asn Tyr Gly Ser Leu Pro Pro Arg Phe Gln Val Phe Asn Phe 
                405                 410                 415     


Thr Asn Phe Asp Val Tyr Gln Ile Asn Thr Arg Ala Asp Ser Thr Gly 
            420                 425                 430         


Thr Phe Arg Ile Pro Gly Phe Ala Val Thr Arg Ala Gln Phe Ile Pro 
        435                 440                 445             


Gly Gly Thr Tyr Ser Val Ala His Arg Asp Pro Gly Ala Cys Gln Gln 
    450                 455                 460                 


Asp Tyr Asp Ser Ile Glu Glu Leu Pro Ser Leu Asp Pro Asp Glu Pro 
465                 470                 475                 480 


Ile Asn Arg Ser Tyr Ser His Arg Leu Ser His Val Thr Leu Tyr Lys 
                485                 490                 495     


Tyr Thr Leu Ser Asp Thr Asp Tyr Gly Val Ile Asn Tyr Thr Asp Tyr 
            500                 505                 510         


Gly Ser Met Pro Ala Tyr Val Trp Thr His Arg Asp Val Asp Leu Thr 
        515                 520                 525             


Asn Thr Ile Thr Ala Asp Arg Ile Thr Gln Leu Pro Leu Val Lys Ala 
    530                 535                 540                 


Ser Thr Leu Pro Ala Gly Thr Thr Val Val Lys Gly Pro Gly Phe Thr 
545                 550                 555                 560 


Gly Gly Asp Ile Leu Arg Arg Thr Thr Asn Gly Thr Phe Gly Thr Leu 
                565                 570                 575     


His Val Arg Val Asn Ser Pro Leu Thr Gln Gln Tyr Arg Leu Arg Val 
            580                 585                 590         


Arg Phe Ala Ser Thr Gly Asn Phe Ser Ile Arg Val Leu Arg Gly Gly 
        595                 600                 605             


Thr Ser Ile Gly Asp Ala Arg Phe Gly Ser Thr Met Asn Arg Gly Gln 
    610                 615                 620                 


Glu Leu Thr Tyr Glu Ser Phe Val Thr Arg Glu Phe Thr Thr Thr Gly 
625                 630                 635                 640 


Pro Phe Asn Pro Pro Phe Thr Phe Thr Gln Thr Gln Glu Ile Leu Thr 
                645                 650                 655     


Val Asn Ala Glu Gly Val Ser Thr Gly Gly Glu Tyr Tyr Ile Asp Ser 
            660                 665                 670         


Ile Glu Ile Val Pro Val Asn Pro Thr Arg Glu Ala Glu Glu Asp Leu 
        675                 680                 685             


Glu Ala Ala Lys Lys Ala Val Ala Ser Leu Phe Thr Arg Thr Arg 
    690                 695                 700             


<210>  3
<211>  3525
<212>  DNA
<213>  Bacillus thuringiensis

<400>  3
atgaatcgaa ataatcaagg tgaatatgaa attattgacg cttccacttg tggttgttcg       60

tcagatgatg ttgttcaata tcctttggca agagatccga atgctgcatt ccaaaatatg      120

aattataaag attatttgaa aatgtctgac ggagactacg tcgattctta tataaaccca      180

ggcttatcta ttggtcgtag agatgtgacc ctaactggag ttggtattgt tgcgctaata      240

gtagggactt taggtggtcc agttgggggt atagtaactg gcttgatttc ctctctttta      300

ggattattgt ggccaagtaa tgataatgat gtatgggaag catttatggc acaaatagaa      360

gagctaattg aacaaaggat agcagatcaa gtagtaagga atgcactcga taacttaact      420

ggattgcgcg attattataa tcaataccta ttagcattgg aggagtggca ggaaaggccg      480

aacgctgtaa gatctacctt agtttttaat agatttgaaa ccctgcattc tcactttgta      540

acaagtatgc ctagctttgg tagtggccct ggaagtgaaa ggtatgcggt acaattgctg      600

acagtttatg cacaagcggc aaatctgcat ttgttattat taagagatgc tgacatttat      660

ggggcaaggt ggggacttcg tgaatctcag attgatttat attttaatga gctacaaaat      720

cgtacacgag attataccaa tcattgtgta actgcgtaca ataatgggtt agaggagata      780

cgaggaacaa gccctgcaag ttggttgagg taccatcaat tccgtagaga gacaacacta      840

atagcattgg atttagtggc gatattccca tattacaacg tacgagaata tccaattggg      900

gtaaatcctc agcttacacg tgatgtatat acagatccaa taggggttac tttcagaaga      960

gaagattggg aaacaggagt agaatgcaga ccatgggtaa atactcctta catgagcttt     1020

tcggatcttg aaaatgcaat aattcgtcca ccacatctat ttgaaacatt acgtaattta     1080

acaattcata caggtcgata taacctagta ggaggggcga gatttattga aggatgggtc     1140

ggacattctg taacaaatac tcgcttgggt aattcaacag tatttacaag taattatggt     1200

tctttgccac ctcgttttca agtttttaat tttactaatt ttgatgttta ccaaattaat     1260

acgagagcag attctacagg tacctttaga atccctggat ttgcagttac aagggcccaa     1320

ttcattccgg gtgggactta ttcagtagct caccgagatc caggggcatg tcaacaagat     1380

tatgattcaa ttgaagagtt accaagtcta gacccggatg aacctattaa tagaagttat     1440

agtcatagat tatcgcatgt taccctttat aaatatactc tctcagatac agattatgga     1500

gttatcaatt atacagatta tggaagtatg cctgcttatg tctggacaca tcgcgatgtg     1560

gaccttacta acacgattac tgcagataga attacacaac tcccattagt aaaggcatct     1620

acactacctg cgggtactac tgtggtaaaa ggcccaggat ttacaggagg agatatactc     1680

cgaagaacaa ctaatggaac atttgggaca ttacatgtaa gggttaattc accattaaca     1740

caacaatatc gcctaagagt tcgttttgcc tcaacaggaa atttcagtat aagggtactc     1800

cgtggaggga cttctatcgg tgatgctaga tttgggagca caatgaacag aggacaggaa     1860

ctaacttacg aatcctttgt cacaagagag tttactacta ctggtccgtt caatccgcct     1920

tttacattta cacaaactca agaaattcta acagtgaatg cagaaggtgt tagcaccggt     1980

ggtgaatatt atatagatag tattgagatt gttcctgtaa atccgacgcg agaggcggaa     2040

gaggatctag aagcagcgaa gaaagcggtg gcgagcttgt ttacacgtac aagggacgga     2100

ttacaagtaa atgtgacaga ttatcaagtc gatcaagcgg caaatttagt gtcatgctta     2160

tcagatgaac aatatgggca tgacaaaaag atgttattgg aagcggtaag agcggcaaaa     2220

cgcctcagcc gagaacgcaa cttacttcag gacccagatt ttaatacaat caatagtaca     2280

gaagaaaatg gatggaaagc aagtaacggc gttactatta gcgagggcgg tccattctat     2340

aaaggccgtg cgcttcagct agcaagcgca agagaaaatt acccaacata catttatcaa     2400

aaagtaaatg catcagagtt aaagccgtat acacgttata gactggatgg gttcgtgaag     2460

agtagtcaag atttagaaat tgatctcatt caccatcata aagtccatct cgtgaaaaat     2520

gtaccagata atttagtatc cgatacttac tcggatggtt cttgcagtgg aatgaatcga     2580

tgtgaggaac aacagatggt aaatgcgcaa ctggaaacag aacatcatca tccgatggat     2640

tgctgtgaag cggctcaaac acatgagttt tcttcctata ttaatacagg cgatctaaat     2700

tcaagtgtag atcaaggcat ttgggttgta ttgaaagttc gaacaaccga tggttatgcg     2760

acgctaggaa atcttgaatt ggtagaggtc ggaccgttat cgggtgaatc tctagaacgt     2820

gaacaaaggg ataatgcgaa atggagtgca gagctaggaa gaaagcgtgc agaaacagat     2880

cgcgtgtatc aagatgccaa acaatccatc aatcatttat ttgtggatta tcaagatcaa     2940

caattaaatc cagaaatagg gatggcagat attattgacg ctcaaaatct tgtcgcatca     3000

atttcagatg tgtatagcga tgcagtactg caaatccctg gaattaacta tgagatttac     3060

acagagctat ccaatcgctt acaacaagca tcgtatctgt atacgtctcg aaatgcggtg     3120

caaaatgggg actttaacag cggtctagat agttggaatg caacaggggg ggctacggta     3180

caacaggatg gcaatacgca tttcttagtt ctttctcatt gggatgcaca agtttctcaa     3240

caatttagag tgcagccgaa ttgtaaatat gtattacgtg taacagcaga gaaagtaggc     3300

ggcggagacg gatacgtgac aatccgggat ggtgctcatc atacagaaaa gctaacattt     3360

aatgcatgtg attatgatat aaatggcacg tacgtgactg ataatacgta tctaacaaaa     3420

gaagtggtat tctattcaca tacagaacac atgtgggtag aggtaagtga aacagaaggt     3480

gcatttcata tagatagtat tgaattcgtt gaaacagaaa agtaa                     3525


<210>  4
<211>  1174
<212>  PRT
<213>  Bacillus thuringiensis

<400>  4

Met Asn Arg Asn Asn Gln Gly Glu Tyr Glu Ile Ile Asp Ala Ser Thr 
1               5                   10                  15      


Cys Gly Cys Ser Ser Asp Asp Val Val Gln Tyr Pro Leu Ala Arg Asp 
            20                  25                  30          


Pro Asn Ala Ala Phe Gln Asn Met Asn Tyr Lys Asp Tyr Leu Lys Met 
        35                  40                  45              


Ser Asp Gly Asp Tyr Val Asp Ser Tyr Ile Asn Pro Gly Leu Ser Ile 
    50                  55                  60                  


Gly Arg Arg Asp Val Thr Leu Thr Gly Val Gly Ile Val Ala Leu Ile 
65                  70                  75                  80  


Val Gly Thr Leu Gly Gly Pro Val Gly Gly Ile Val Thr Gly Leu Ile 
                85                  90                  95      


Ser Ser Leu Leu Gly Leu Leu Trp Pro Ser Asn Asp Asn Asp Val Trp 
            100                 105                 110         


Glu Ala Phe Met Ala Gln Ile Glu Glu Leu Ile Glu Gln Arg Ile Ala 
        115                 120                 125             


Asp Gln Val Val Arg Asn Ala Leu Asp Asn Leu Thr Gly Leu Arg Asp 
    130                 135                 140                 


Tyr Tyr Asn Gln Tyr Leu Leu Ala Leu Glu Glu Trp Gln Glu Arg Pro 
145                 150                 155                 160 


Asn Ala Val Arg Ser Thr Leu Val Phe Asn Arg Phe Glu Thr Leu His 
                165                 170                 175     


Ser His Phe Val Thr Ser Met Pro Ser Phe Gly Ser Gly Pro Gly Ser 
            180                 185                 190         


Glu Arg Tyr Ala Val Gln Leu Leu Thr Val Tyr Ala Gln Ala Ala Asn 
        195                 200                 205             


Leu His Leu Leu Leu Leu Arg Asp Ala Asp Ile Tyr Gly Ala Arg Trp 
    210                 215                 220                 


Gly Leu Arg Glu Ser Gln Ile Asp Leu Tyr Phe Asn Glu Leu Gln Asn 
225                 230                 235                 240 


Arg Thr Arg Asp Tyr Thr Asn His Cys Val Thr Ala Tyr Asn Asn Gly 
                245                 250                 255     


Leu Glu Glu Ile Arg Gly Thr Ser Pro Ala Ser Trp Leu Arg Tyr His 
            260                 265                 270         


Gln Phe Arg Arg Glu Thr Thr Leu Ile Ala Leu Asp Leu Val Ala Ile 
        275                 280                 285             


Phe Pro Tyr Tyr Asn Val Arg Glu Tyr Pro Ile Gly Val Asn Pro Gln 
    290                 295                 300                 


Leu Thr Arg Asp Val Tyr Thr Asp Pro Ile Gly Val Thr Phe Arg Arg 
305                 310                 315                 320 


Glu Asp Trp Glu Thr Gly Val Glu Cys Arg Pro Trp Val Asn Thr Pro 
                325                 330                 335     


Tyr Met Ser Phe Ser Asp Leu Glu Asn Ala Ile Ile Arg Pro Pro His 
            340                 345                 350         


Leu Phe Glu Thr Leu Arg Asn Leu Thr Ile His Thr Gly Arg Tyr Asn 
        355                 360                 365             


Leu Val Gly Gly Ala Arg Phe Ile Glu Gly Trp Val Gly His Ser Val 
    370                 375                 380                 


Thr Asn Thr Arg Leu Gly Asn Ser Thr Val Phe Thr Ser Asn Tyr Gly 
385                 390                 395                 400 


Ser Leu Pro Pro Arg Phe Gln Val Phe Asn Phe Thr Asn Phe Asp Val 
                405                 410                 415     


Tyr Gln Ile Asn Thr Arg Ala Asp Ser Thr Gly Thr Phe Arg Ile Pro 
            420                 425                 430         


Gly Phe Ala Val Thr Arg Ala Gln Phe Ile Pro Gly Gly Thr Tyr Ser 
        435                 440                 445             


Val Ala His Arg Asp Pro Gly Ala Cys Gln Gln Asp Tyr Asp Ser Ile 
    450                 455                 460                 


Glu Glu Leu Pro Ser Leu Asp Pro Asp Glu Pro Ile Asn Arg Ser Tyr 
465                 470                 475                 480 


Ser His Arg Leu Ser His Val Thr Leu Tyr Lys Tyr Thr Leu Ser Asp 
                485                 490                 495     


Thr Asp Tyr Gly Val Ile Asn Tyr Thr Asp Tyr Gly Ser Met Pro Ala 
            500                 505                 510         


Tyr Val Trp Thr His Arg Asp Val Asp Leu Thr Asn Thr Ile Thr Ala 
        515                 520                 525             


Asp Arg Ile Thr Gln Leu Pro Leu Val Lys Ala Ser Thr Leu Pro Ala 
    530                 535                 540                 


Gly Thr Thr Val Val Lys Gly Pro Gly Phe Thr Gly Gly Asp Ile Leu 
545                 550                 555                 560 


Arg Arg Thr Thr Asn Gly Thr Phe Gly Thr Leu His Val Arg Val Asn 
                565                 570                 575     


Ser Pro Leu Thr Gln Gln Tyr Arg Leu Arg Val Arg Phe Ala Ser Thr 
            580                 585                 590         


Gly Asn Phe Ser Ile Arg Val Leu Arg Gly Gly Thr Ser Ile Gly Asp 
        595                 600                 605             


Ala Arg Phe Gly Ser Thr Met Asn Arg Gly Gln Glu Leu Thr Tyr Glu 
    610                 615                 620                 


Ser Phe Val Thr Arg Glu Phe Thr Thr Thr Gly Pro Phe Asn Pro Pro 
625                 630                 635                 640 


Phe Thr Phe Thr Gln Thr Gln Glu Ile Leu Thr Val Asn Ala Glu Gly 
                645                 650                 655     


Val Ser Thr Gly Gly Glu Tyr Tyr Ile Asp Ser Ile Glu Ile Val Pro 
            660                 665                 670         


Val Asn Pro Thr Arg Glu Ala Glu Glu Asp Leu Glu Ala Ala Lys Lys 
        675                 680                 685             


Ala Val Ala Ser Leu Phe Thr Arg Thr Arg Asp Gly Leu Gln Val Asn 
    690                 695                 700                 


Val Thr Asp Tyr Gln Val Asp Gln Ala Ala Asn Leu Val Ser Cys Leu 
705                 710                 715                 720 


Ser Asp Glu Gln Tyr Gly His Asp Lys Lys Met Leu Leu Glu Ala Val 
                725                 730                 735     


Arg Ala Ala Lys Arg Leu Ser Arg Glu Arg Asn Leu Leu Gln Asp Pro 
            740                 745                 750         


Asp Phe Asn Thr Ile Asn Ser Thr Glu Glu Asn Gly Trp Lys Ala Ser 
        755                 760                 765             


Asn Gly Val Thr Ile Ser Glu Gly Gly Pro Phe Tyr Lys Gly Arg Ala 
    770                 775                 780                 


Leu Gln Leu Ala Ser Ala Arg Glu Asn Tyr Pro Thr Tyr Ile Tyr Gln 
785                 790                 795                 800 


Lys Val Asn Ala Ser Glu Leu Lys Pro Tyr Thr Arg Tyr Arg Leu Asp 
                805                 810                 815     


Gly Phe Val Lys Ser Ser Gln Asp Leu Glu Ile Asp Leu Ile His His 
            820                 825                 830         


His Lys Val His Leu Val Lys Asn Val Pro Asp Asn Leu Val Ser Asp 
        835                 840                 845             


Thr Tyr Ser Asp Gly Ser Cys Ser Gly Met Asn Arg Cys Glu Glu Gln 
    850                 855                 860                 


Gln Met Val Asn Ala Gln Leu Glu Thr Glu His His His Pro Met Asp 
865                 870                 875                 880 


Cys Cys Glu Ala Ala Gln Thr His Glu Phe Ser Ser Tyr Ile Asn Thr 
                885                 890                 895     


Gly Asp Leu Asn Ser Ser Val Asp Gln Gly Ile Trp Val Val Leu Lys 
            900                 905                 910         


Val Arg Thr Thr Asp Gly Tyr Ala Thr Leu Gly Asn Leu Glu Leu Val 
        915                 920                 925             


Glu Val Gly Pro Leu Ser Gly Glu Ser Leu Glu Arg Glu Gln Arg Asp 
    930                 935                 940                 


Asn Ala Lys Trp Ser Ala Glu Leu Gly Arg Lys Arg Ala Glu Thr Asp 
945                 950                 955                 960 


Arg Val Tyr Gln Asp Ala Lys Gln Ser Ile Asn His Leu Phe Val Asp 
                965                 970                 975     


Tyr Gln Asp Gln Gln Leu Asn Pro Glu Ile Gly Met Ala Asp Ile Ile 
            980                 985                 990         


Asp Ala Gln Asn Leu Val Ala Ser  Ile Ser Asp Val Tyr  Ser Asp Ala 
        995                 1000                 1005             


Val Leu  Gln Ile Pro Gly Ile  Asn Tyr Glu Ile Tyr  Thr Glu Leu 
    1010                 1015                 1020             


Ser Asn  Arg Leu Gln Gln Ala  Ser Tyr Leu Tyr Thr  Ser Arg Asn 
    1025                 1030                 1035             


Ala Val  Gln Asn Gly Asp Phe  Asn Ser Gly Leu Asp  Ser Trp Asn 
    1040                 1045                 1050             


Ala Thr  Gly Gly Ala Thr Val  Gln Gln Asp Gly Asn  Thr His Phe 
    1055                 1060                 1065             


Leu Val  Leu Ser His Trp Asp  Ala Gln Val Ser Gln  Gln Phe Arg 
    1070                 1075                 1080             


Val Gln  Pro Asn Cys Lys Tyr  Val Leu Arg Val Thr  Ala Glu Lys 
    1085                 1090                 1095             


Val Gly  Gly Gly Asp Gly Tyr  Val Thr Ile Arg Asp  Gly Ala His 
    1100                 1105                 1110             


His Thr  Glu Lys Leu Thr Phe  Asn Ala Cys Asp Tyr  Asp Ile Asn 
    1115                 1120                 1125             


Gly Thr  Tyr Val Thr Asp Asn  Thr Tyr Leu Thr Lys  Glu Val Val 
    1130                 1135                 1140             


Phe Tyr  Ser His Thr Glu His  Met Trp Val Glu Val  Ser Glu Thr 
    1145                 1150                 1155             


Glu Gly  Ala Phe His Ile Asp  Ser Ile Glu Phe Val  Glu Thr Glu 
    1160                 1165                 1170             


Lys 
    


