                         SEQUENCE LISTING

<110>  Glenmark Pharmaceuticals SA
 
<120>  Antibodies that bind to CCR6 and their uses

<130>  PCT application

<150>  EP 14189374.3
<151>  2014-10-17

<160>  257   

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  1

Gly Phe Ser Phe Ser Asp Tyr Tyr Met Tyr 
1               5                   10  


<210>  2
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  2

Tyr Ile Thr Asn Gly Gly Ile Thr Tyr Tyr Pro Asp Thr Val Lys Gly 
1               5                   10                  15      


<210>  3
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  3

Thr Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr 
1               5                   10      


<210>  4
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  4

Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10              


<210>  5
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  5

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  6

Phe Gln Gly Ser His Val Pro Leu Thr 
1               5                   


<210>  7
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  7

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Ile Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Thr Asn Gly Gly Ile Thr Tyr Tyr Pro Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Arg Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  8
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  8

Asp Val Ile Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  9
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H11VH5-CH1FabHC

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Asn Gly Gly Ile Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220 


<210>  10
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H11VH5 IgG1

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Asn Gly Gly Ile Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  11
<211>  1125
<212>  DNA
<213>  Homo sapiens

<400>  11
atgagcgggg aatcaatgaa tttcagcgat gttttcgact ccagtgaaga ttattttgtg       60

tcagtcaata cttcatatta ctcagttgat tctgagatgt tactgtgctc cttgcaggag      120

gtcaggcagt tctccaggct atttgtaccg attgcctact ccttgatctg tgtctttggc      180

ctcctgggga atattctggt ggtgatcacc tttgcttttt ataagaaggc caggtctatg      240

acagacgtct atctcttgaa catggccatt gcagacatcc tctttgttct tactctccca      300

ttctgggcag tgagtcatgc cactggtgcg tgggttttca gcaatgccac gtgcaagttg      360

ctaaaaggca tctatgccat caactttaac tgcgggatgc tgctcctgac ttgcattagc      420

atggaccggt acatcgccat tgtacaggcg actaagtcat tccggctccg atccagaaca      480

ctaccgcgca gcaaaatcat ctgccttgtt gtgtgggggc tgtcagtcat catctccagc      540

tcaacttttg tcttcaacca aaaatacaac acccaaggca gcgatgtctg tgaacccaag      600

taccagactg tctcggagcc catcaggtgg aagctgctga tgttggggct tgagctactc      660

tttggtttct ttatcccttt gatgttcatg atattttgtt acacgttcat tgtcaaaacc      720

ttggtgcaag ctcagaattc taaaaggcac aaagccatcc gtgtaatcat agctgtggtg      780

cttgtgtttc tggcttgtca gattcctcat aacatggtcc tgcttgtgac ggctgcaaat      840

ttgggtaaaa tgaaccgatc ctgccagagc gaaaagctaa ttggctatac gaaaactgtc      900

acagaagtcc tggctttcct gcactgctgc ctgaaccctg tgctctacgc ttttattggg      960

cagaagttca gaaactactt tctgaagatc ttgaaggacc tgtggtgtgt gagaaggaag     1020

tacaagtcct caggcttctc ctgtgccggg aggtactcag aaaacatttc tcggcagacc     1080

agtgagaccg cagataacga caatgcgtcg tccttcacta tgtga                     1125


<210>  12
<211>  1104
<212>  DNA
<213>  Mus musculus

<400>  12
atgaattcca cagagtccta ctttggaacg gatgattatg acaacacaga gtattattct       60

attcctccag accatgggcc atgctcccta gaagaggtca gaaacttcac caaggtattt      120

gtgccaattg cctactcctt aatatgtgtc tttggcctcc tgggcaacat tatggtggtg      180

atgacctttg ccttctacaa gaaagccaga tccatgactg acgtctacct gttgaacatg      240

gccatcacag acatactctt tgtcctcacc ctaccgttct gggcagttac tcatgccacc      300

aacacttggg ttttcagcga tgcactgtgt aaactgatga aaggcacata tgcggtcaac      360

tttaactgtg ggatgctgct cctggcctgt atcagcatgg accggtacat tgccatcgtc      420

caggcaacca aatctttccg ggtacgctcc agaacactga cgcacagtaa ggtcatctgt      480

gtggcagtgt ggttcatctc catcatcatc tcaagcccta catttatctt caacaagaaa      540

tacgagctgc aggatcgtga tgtctgtgag ccacggtaca ggtctgtctc agagcccatc      600

acgtggaagc tgctgggtat gggactggag ctgttctttg ggttcttcac ccctttgctg      660

tttatggtgt tctgctatct gttcattatc aagaccttgg tgcaggccca gaactccaag      720

aggcacagag ccatccgagt cgtgatcgct gtggttctcg tgttcctggc ttgtcagatc      780

cctcacaaca tggtcctcct cgtgactgcg gtcaacacgg gcaaagtggg ccggagctgc      840

agcaccgaga aagtcctcgc ctacaccagg aacgtggccg aggtcctggc tttcctgcat      900

tgctgcctca accccgtgtt gtatgcgttt attggacaga aattcagaaa ctacttcatg      960

aagatcatga aggatgtgtg gtgtatgaga aggaagaata agatgcctgg cttcctctgt     1020

gcccgggttt actcggaaag ctacatctcc aggcagacca gtgagaccgt cgaaaatgat     1080

aatgcatcgt cctttaccat gtaa                                            1104


<210>  13
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human-Mouse CCR6 fusion

<400>  13

Met Ser Gly Glu Ser Met Asn Phe Ser Asp Val Phe Asp Ser Ser Glu 
1               5                   10                  15      


Asp Tyr Phe Val Ser Val Asn Thr Ser Tyr Tyr Ser Val Asp Ser Glu 
            20                  25                  30          


Met Leu Leu Cys Ser Leu Gln Glu Val Arg Gln Phe Ser Arg Leu Phe 
        35                  40                  45              


Val Pro Ile Ala Tyr Ser Leu Ile Cys Val Phe Gly Leu Leu Gly Asn 
    50                  55                  60                  


Ile Leu Val Val Ile Thr Phe Ala Phe Tyr Lys Lys Ala Arg Ser Met 
65                  70                  75                  80  


Thr Asp Val Tyr Leu Leu Asn Met Ala Ile Ala Asp Ile Leu Phe Val 
                85                  90                  95      


Leu Thr Leu Pro Phe Trp Ala Val Thr His Ala Thr Asn Thr Trp Val 
            100                 105                 110         


Phe Ser Asp Ala Leu Cys Lys Leu Leu Lys Gly Ile Tyr Ala Ile Asn 
        115                 120                 125             


Phe Asn Cys Gly Met Leu Leu Leu Thr Cys Ile Ser Met Asp Arg Tyr 
    130                 135                 140                 


Ile Ala Ile Val Gln Ala Thr Lys Ser Phe Arg Leu Arg Ser Arg Thr 
145                 150                 155                 160 


Leu Pro Arg Ser Lys Ile Ile Cys Leu Val Val Trp Gly Leu Ser Val 
                165                 170                 175     


Ile Ile Ser Ser Ser Thr Phe Val Phe Asn Gln Lys Tyr Asn Thr Gln 
            180                 185                 190         


Gly Ser Asp Val Cys Glu Pro Lys Tyr Gln Thr Val Ser Glu Pro Ile 
        195                 200                 205             


Arg Trp Lys Leu Leu Met Leu Gly Leu Glu Leu Leu Phe Gly Phe Phe 
    210                 215                 220                 


Ile Pro Leu Met Phe Met Ile Phe Cys Tyr Thr Phe Ile Val Lys Thr 
225                 230                 235                 240 


Leu Val Gln Ala Gln Asn Ser Lys Arg His Lys Ala Ile Arg Val Ile 
                245                 250                 255     


Ile Ala Val Val Leu Val Phe Leu Ala Cys Gln Ile Pro His Asn Met 
            260                 265                 270         


Val Leu Leu Val Thr Ala Ala Asn Leu Gly Lys Met Asn Arg Ser Cys 
        275                 280                 285             


Gln Ser Glu Lys Leu Ile Gly Tyr Thr Lys Thr Val Thr Glu Val Leu 
    290                 295                 300                 


Ala Phe Leu His Cys Cys Leu Asn Pro Val Leu Tyr Ala Phe Ile Gly 
305                 310                 315                 320 


Gln Lys Phe Arg Asn Tyr Phe Leu Lys Ile Leu Lys Asp Leu Trp Cys 
                325                 330                 335     


Val Arg Arg Lys Tyr Lys Ser Ser Gly Phe Ser Cys Ala Gly Arg Tyr 
            340                 345                 350         


Ser Glu Asn Ile Ser Arg Gln Thr Ser Glu Thr Ala Asp Asn Asp Asn 
        355                 360                 365             


Ala Ser Ser Phe Thr Met 
    370                 


<210>  14
<211>  1125
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human-Mouse CCR6 fusion

<400>  14
atgagcgggg aatcaatgaa tttcagcgat gttttcgact ccagtgaaga ttattttgtg       60

tcagtcaata cttcatatta ctcagttgat tctgagatgt tactgtgctc cttgcaggag      120

gtcaggcagt tctccaggct atttgtaccg attgcctact ccttgatctg tgtctttggc      180

ctcctgggga atattctggt ggtgatcacc tttgcttttt ataagaaggc caggtctatg      240

acagacgtct atctcttgaa catggccatt gcagacatcc tctttgttct tactctccca      300

ttctgggcag tgactcatgc caccaacact tgggttttca gcgatgcact gtgtaaattg      360

ctaaaaggca tctatgccat caactttaac tgcgggatgc tgctcctgac ttgcattagc      420

atggaccggt acatcgccat tgtacaggcg actaagtcat tccggctccg atccagaaca      480

ctaccgcgca gcaaaatcat ctgccttgtt gtgtgggggc tgtcagtcat catctccagc      540

tcaacttttg tcttcaacca aaaatacaac acccaaggca gcgatgtctg tgaacccaag      600

taccagactg tctcggagcc catcaggtgg aagctgctga tgttggggct tgagctactc      660

tttggtttct ttatcccttt gatgttcatg atattttgtt acacgttcat tgtcaaaacc      720

ttggtgcaag ctcagaattc taaaaggcac aaagccatcc gtgtaatcat agctgtggtg      780

cttgtgtttc tggcttgtca gattcctcat aacatggtcc tgcttgtgac ggctgcaaat      840

ttgggtaaaa tgaaccgatc ctgccagagc gaaaagctaa ttggctatac gaaaactgtc      900

acagaagtcc tggctttcct gcactgctgc ctgaaccctg tgctctacgc ttttattggg      960

cagaagttca gaaactactt tctgaagatc ttgaaggacc tgtggtgtgt gagaaggaag     1020

tacaagtcct caggcttctc ctgtgccggg aggtactcag aaaacatttc tcggcagacc     1080

agtgagaccg cagataacga caatgcgtcg tccttcacta tgtga                     1125


<210>  15
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human-Mouse CCR6 fusion

<400>  15

Met Ser Gly Glu Ser Met Asn Phe Ser Asp Val Phe Asp Ser Ser Glu 
1               5                   10                  15      


Asp Tyr Phe Val Ser Val Asn Thr Ser Tyr Tyr Ser Val Asp Ser Glu 
            20                  25                  30          


Met Leu Leu Cys Ser Leu Gln Glu Val Arg Gln Phe Ser Arg Leu Phe 
        35                  40                  45              


Val Pro Ile Ala Tyr Ser Leu Ile Cys Val Phe Gly Leu Leu Gly Asn 
    50                  55                  60                  


Ile Leu Val Val Ile Thr Phe Ala Phe Tyr Lys Lys Ala Arg Ser Met 
65                  70                  75                  80  


Thr Asp Val Tyr Leu Leu Asn Met Ala Ile Ala Asp Ile Leu Phe Val 
                85                  90                  95      


Leu Thr Leu Pro Phe Trp Ala Val Ser His Ala Thr Gly Ala Trp Val 
            100                 105                 110         


Phe Ser Asn Ala Thr Cys Lys Leu Leu Lys Gly Ile Tyr Ala Ile Asn 
        115                 120                 125             


Phe Asn Cys Gly Met Leu Leu Leu Thr Cys Ile Ser Met Asp Arg Tyr 
    130                 135                 140                 


Ile Ala Ile Val Gln Ala Thr Lys Ser Phe Arg Leu Arg Ser Arg Thr 
145                 150                 155                 160 


Leu Pro Arg Ser Lys Ile Ile Cys Leu Val Val Trp Gly Leu Ser Val 
                165                 170                 175     


Ile Ile Ser Ser Pro Thr Phe Ile Phe Asn Lys Lys Tyr Glu Leu Gln 
            180                 185                 190         


Asp Arg Asp Val Cys Glu Pro Arg Tyr Arg Ser Val Ser Glu Pro Ile 
        195                 200                 205             


Thr Trp Lys Leu Leu Met Leu Gly Leu Glu Leu Leu Phe Gly Phe Phe 
    210                 215                 220                 


Ile Pro Leu Met Phe Met Ile Phe Cys Tyr Thr Phe Ile Val Lys Thr 
225                 230                 235                 240 


Leu Val Gln Ala Gln Asn Ser Lys Arg His Lys Ala Ile Arg Val Ile 
                245                 250                 255     


Ile Ala Val Val Leu Val Phe Leu Ala Cys Gln Ile Pro His Asn Met 
            260                 265                 270         


Val Leu Leu Val Thr Ala Ala Asn Leu Gly Lys Met Asn Arg Ser Cys 
        275                 280                 285             


Gln Ser Glu Lys Leu Ile Gly Tyr Thr Lys Thr Val Thr Glu Val Leu 
    290                 295                 300                 


Ala Phe Leu His Cys Cys Leu Asn Pro Val Leu Tyr Ala Phe Ile Gly 
305                 310                 315                 320 


Gln Lys Phe Arg Asn Tyr Phe Leu Lys Ile Leu Lys Asp Leu Trp Cys 
                325                 330                 335     


Val Arg Arg Lys Tyr Lys Ser Ser Gly Phe Ser Cys Ala Gly Arg Tyr 
            340                 345                 350         


Ser Glu Asn Ile Ser Arg Gln Thr Ser Glu Thr Ala Asp Asn Asp Asn 
        355                 360                 365             


Ala Ser Ser Phe Thr Met 
    370                 


<210>  16
<211>  1125
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human-Mouse CCR6 fusion

<400>  16
atgagcgggg aatcaatgaa tttcagcgat gttttcgact ccagtgaaga ttattttgtg       60

tcagtcaata cttcatatta ctcagttgat tctgagatgt tactgtgctc cttgcaggag      120

gtcaggcagt tctccaggct atttgtaccg attgcctact ccttgatctg tgtctttggc      180

ctcctgggga atattctggt ggtgatcacc tttgcttttt ataagaaggc caggtctatg      240

acagacgtct atctcttgaa catggccatt gcagacatcc tctttgttct tactctccca      300

ttctgggcag tgagtcatgc cactggtgcg tgggttttca gcaatgccac gtgcaagttg      360

ctaaaaggca tctatgccat caactttaac tgcgggatgc tgctcctgac ttgcattagc      420

atggaccggt acatcgccat tgtacaggcg actaagtcat tccggctccg atccagaaca      480

ctaccgcgca gcaaaatcat ctgccttgtt gtgtgggggc tgtcagtcat catctccagc      540

cctacattta tcttcaacaa gaaatacgag ctgcaggatc gtgatgtctg tgagccacgg      600

tacaggtctg tctcagagcc catcacgtgg aagctgctga tgttggggct tgagctactc      660

tttggtttct ttatcccttt gatgttcatg atattttgtt acacgttcat tgtcaaaacc      720

ttggtgcaag ctcagaattc taaaaggcac aaagccatcc gtgtaatcat agctgtggtg      780

cttgtgtttc tggcttgtca gattcctcat aacatggtcc tgcttgtgac ggctgcaaat      840

ttgggtaaaa tgaaccgatc ctgccagagc gaaaagctaa ttggctatac gaaaactgtc      900

acagaagtcc tggctttcct gcactgctgc ctgaaccctg tgctctacgc ttttattggg      960

cagaagttca gaaactactt tctgaagatc ttgaaggacc tgtggtgtgt gagaaggaag     1020

tacaagtcct caggcttctc ctgtgccggg aggtactcag aaaacatttc tcggcagacc     1080

agtgagaccg cagataacga caatgcgtcg tccttcacta tgtga                     1125


<210>  17
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human-Mouse CCR6 fusion

<400>  17

Met Ser Gly Glu Ser Met Asn Phe Ser Asp Val Phe Asp Ser Ser Glu 
1               5                   10                  15      


Asp Tyr Phe Val Ser Val Asn Thr Ser Tyr Tyr Ser Val Asp Ser Glu 
            20                  25                  30          


Met Leu Leu Cys Ser Leu Gln Glu Val Arg Gln Phe Ser Arg Leu Phe 
        35                  40                  45              


Val Pro Ile Ala Tyr Ser Leu Ile Cys Val Phe Gly Leu Leu Gly Asn 
    50                  55                  60                  


Ile Leu Val Val Ile Thr Phe Ala Phe Tyr Lys Lys Ala Arg Ser Met 
65                  70                  75                  80  


Thr Asp Val Tyr Leu Leu Asn Met Ala Ile Ala Asp Ile Leu Phe Val 
                85                  90                  95      


Leu Thr Leu Pro Phe Trp Ala Val Ser His Ala Thr Gly Ala Trp Val 
            100                 105                 110         


Phe Ser Asn Ala Thr Cys Lys Leu Leu Lys Gly Ile Tyr Ala Ile Asn 
        115                 120                 125             


Phe Asn Cys Gly Met Leu Leu Leu Thr Cys Ile Ser Met Asp Arg Tyr 
    130                 135                 140                 


Ile Ala Ile Val Gln Ala Thr Lys Ser Phe Arg Leu Arg Ser Arg Thr 
145                 150                 155                 160 


Leu Pro Arg Ser Lys Ile Ile Cys Leu Val Val Trp Gly Leu Ser Val 
                165                 170                 175     


Ile Ile Ser Ser Ser Thr Phe Val Phe Asn Gln Lys Tyr Asn Thr Gln 
            180                 185                 190         


Gly Ser Asp Val Cys Glu Pro Lys Tyr Gln Thr Val Ser Glu Pro Ile 
        195                 200                 205             


Arg Trp Lys Leu Leu Met Leu Gly Leu Glu Leu Leu Phe Gly Phe Phe 
    210                 215                 220                 


Ile Pro Leu Met Phe Met Ile Phe Cys Tyr Thr Phe Ile Val Lys Thr 
225                 230                 235                 240 


Leu Val Gln Ala Gln Asn Ser Lys Arg His Lys Ala Ile Arg Val Ile 
                245                 250                 255     


Ile Ala Val Val Leu Val Phe Leu Ala Cys Gln Ile Pro His Asn Met 
            260                 265                 270         


Val Leu Leu Val Thr Ala Ala Asn Thr Gly Lys Val Gly Arg Ser Cys 
        275                 280                 285             


Ser Thr Glu Lys Val Leu Ala Tyr Thr Arg Asn Val Ala Glu Val Leu 
    290                 295                 300                 


Ala Phe Leu His Cys Cys Leu Asn Pro Val Leu Tyr Ala Phe Ile Gly 
305                 310                 315                 320 


Gln Lys Phe Arg Asn Tyr Phe Leu Lys Ile Leu Lys Asp Leu Trp Cys 
                325                 330                 335     


Val Arg Arg Lys Tyr Lys Ser Ser Gly Phe Ser Cys Ala Gly Arg Tyr 
            340                 345                 350         


Ser Glu Asn Ile Ser Arg Gln Thr Ser Glu Thr Ala Asp Asn Asp Asn 
        355                 360                 365             


Ala Ser Ser Phe Thr Met 
    370                 


<210>  18
<211>  1125
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human-Mouse CCR6 fusion

<400>  18
atgagcgggg aatcaatgaa tttcagcgat gttttcgact ccagtgaaga ttattttgtg       60

tcagtcaata cttcatatta ctcagttgat tctgagatgt tactgtgctc cttgcaggag      120

gtcaggcagt tctccaggct atttgtaccg attgcctact ccttgatctg tgtctttggc      180

ctcctgggga atattctggt ggtgatcacc tttgcttttt ataagaaggc caggtctatg      240

acagacgtct atctcttgaa catggccatt gcagacatcc tctttgttct tactctccca      300

ttctgggcag tgagtcatgc cactggtgcg tgggttttca gcaatgccac gtgcaagttg      360

ctaaaaggca tctatgccat caactttaac tgcgggatgc tgctcctgac ttgcattagc      420

atggaccggt acatcgccat tgtacaggcg actaagtcat tccggctccg atccagaaca      480

ctaccgcgca gcaaaatcat ctgccttgtt gtgtgggggc tgtcagtcat catctccagc      540

tcaacttttg tcttcaacca aaaatacaac acccaaggca gcgatgtctg tgaacccaag      600

taccagactg tctcggagcc catcaggtgg aagctgctga tgttggggct tgagctactc      660

tttggtttct ttatcccttt gatgttcatg atattttgtt acacgttcat tgtcaaaacc      720

ttggtgcaag ctcagaattc taaaaggcac aaagccatcc gtgtaatcat agctgtggtg      780

cttgtgtttc tggcttgtca gattcctcat aacatggtcc tgcttgtgac ggctgcaaac      840

acgggcaaag tgggccggag ctgcagcacc gagaaagtcc tcgcctacac caggaacgtg      900

gccgaggtcc tggctttcct gcactgctgc ctgaaccctg tgctctacgc ttttattggg      960

cagaagttca gaaactactt tctgaagatc ttgaaggacc tgtggtgtgt gagaaggaag     1020

tacaagtcct caggcttctc ctgtgccggg aggtactcag aaaacatttc tcggcagacc     1080

agtgagaccg cagataacga caatgcgtcg tccttcacta tgtga                     1125


<210>  19
<211>  447
<212>  PRT
<213>  Mus musculus

<400>  19

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Ile Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Thr Asn Gly Gly Ile Thr Tyr Tyr Pro Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Arg Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  20
<211>  448
<212>  PRT
<213>  Mus musculus

<400>  20

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Thr Asn Gly Val Gly Asn Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Arg Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  21
<211>  448
<212>  PRT
<213>  Mus musculus

<400>  21

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Thr Thr Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Thr Asn Gly Val Gly Asn Thr Tyr Tyr Pro Asn Thr Val 
    50                  55                  60                  


Asn Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Arg Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Ile Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  22
<211>  448
<212>  PRT
<213>  Mus musculus

<400>  22

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Asn Gly Val Gly Asn Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Arg Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  23
<211>  448
<212>  PRT
<213>  Mus musculus

<400>  23

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Arg Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Thr Asn Asp Val Gly Lys Thr Tyr Tyr Ser Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Arg Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Ile Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  24
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH5IgG4S228PHC

<400>  24

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Asn Gly Gly Ile Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Leu Gly Lys 
    450     


<210>  25
<211>  219
<212>  PRT
<213>  Mus musculus

<400>  25

Asp Val Ile Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  26
<211>  219
<212>  PRT
<213>  Mus musculus

<400>  26

Asp Val Ile Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  27
<211>  219
<212>  PRT
<213>  Mus musculus

<400>  27

Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  28
<211>  219
<212>  PRT
<213>  Mus musculus

<400>  28

Asp Val Ile Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  29
<211>  219
<212>  PRT
<213>  Mus musculus

<400>  29

Asp Val Ile Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  30
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL1LC

<400>  30

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  31
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  31

Gly Phe Ser Phe Ser Asp Tyr Tyr Met Tyr 
1               5                   10  


<210>  32
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  32

Tyr Ile Thr Asn Gly Gly Ile Thr Tyr Tyr Pro Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  33
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  33

Thr Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr 
1               5                   10      


<210>  34
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  34

Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10              


<210>  35
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  35

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  36
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  36

Phe Gln Gly Ser His Val Pro Leu Thr 
1               5                   


<210>  37
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH5 IgG4 S228P HC variable

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Asn Gly Gly Ile Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  38
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL1 LC variable

<400>  38

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  39
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  39

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Thr Asn Gly Val Gly Asn Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Arg Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  40
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  40

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Thr Thr Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Thr Asn Gly Val Gly Asn Thr Tyr Tyr Pro Asn Thr Val 
    50                  55                  60                  


Asn Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Arg Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Ile Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  41
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  41

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Asn Gly Val Gly Asn Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Arg Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  42
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  42

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Arg Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Thr Asn Asp Val Gly Lys Thr Tyr Tyr Ser Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Arg Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Ile Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  43
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  43

Asp Val Ile Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  44
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  44

Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  45
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  45

Asp Val Ile Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  46
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  46

Asp Val Ile Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  47
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  47

Gly Phe Thr Phe Ser Asp Tyr Tyr Met Tyr 
1               5                   10  


<210>  48
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  48

Gly Phe Thr Phe Ser Asp Tyr Tyr Met Tyr 
1               5                   10  


<210>  49
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  49

Gly Phe Ser Phe Ser Asp Tyr Tyr Met Tyr 
1               5                   10  


<210>  50
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  50

Gly Phe Thr Phe Ser Asp Tyr Tyr Met Tyr 
1               5                   10  


<210>  51
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  51

Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10              


<210>  52
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  52

Gln Asn Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10              


<210>  53
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  53

Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10              


<210>  54
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  54

Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10              


<210>  55
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  55

Ile Thr Asn Gly Val Gly Asn Thr Tyr Tyr Pro Asp Thr Val Lys Gly 
1               5                   10                  15      


<210>  56
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  56

Ile Thr Asn Gly Val Gly Asn Thr Tyr Tyr Pro Asn Thr Val Asn Gly 
1               5                   10                  15      


<210>  57
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  57

Ile Ser Asn Gly Val Gly Asn Thr Tyr Tyr Pro Asp Thr Val Lys Gly 
1               5                   10                  15      


<210>  58
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  58

Ile Thr Asn Asp Val Gly Lys Thr Tyr Tyr Ser Asp Thr Val Lys Gly 
1               5                   10                  15      


<210>  59
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  59

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  60
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  60

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  61
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  61

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  62
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  62

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  63
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  63

Ala Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr 
1               5                   10      


<210>  64
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  64

Ala Ser Pro Ile Arg Gly Ala Trp Phe Ala Tyr 
1               5                   10      


<210>  65
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  65

Ala Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr 
1               5                   10      


<210>  66
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  66

Ala Ser Pro Ile Arg Gly Ala Trp Phe Ala Tyr 
1               5                   10      


<210>  67
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  67

Phe Gln Gly Ser His Val Pro Leu Thr 
1               5                   


<210>  68
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  68

Phe Gln Gly Ser His Val Pro Leu Thr 
1               5                   


<210>  69
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  69

Phe Gln Gly Ser His Val Pro Leu Thr 
1               5                   


<210>  70
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  70

Phe Gln Gly Ser His Val Pro Leu Thr 
1               5                   


<210>  71
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Ser Gly Glu Ser Met Asn Phe Ser Asp Val Phe Asp Ser Ser Glu 
1               5                   10                  15      


Asp Tyr Phe Val Ser Val Asn Thr Ser Tyr Tyr Ser Val Asp Ser Glu 
            20                  25                  30          


Met Leu Leu Cys Ser Leu Gln Glu Val Arg Gln Phe Ser Arg Leu Phe 
        35                  40                  45              


Val Pro Ile Ala Tyr Ser Leu Ile Cys Val Phe Gly Leu Leu Gly Asn 
    50                  55                  60                  


Ile Leu Val Val Ile Thr Phe Ala Phe Tyr Lys Lys Ala Arg Ser Met 
65                  70                  75                  80  


Thr Asp Val Tyr Leu Leu Asn Met Ala Ile Ala Asp Ile Leu Phe Val 
                85                  90                  95      


Leu Thr Leu Pro Phe Trp Ala Val Ser His Ala Thr Gly Ala Trp Val 
            100                 105                 110         


Phe Ser Asn Ala Thr Cys Lys Leu Leu Lys Gly Ile Tyr Ala Ile Asn 
        115                 120                 125             


Phe Asn Cys Gly Met Leu Leu Leu Thr Cys Ile Ser Met Asp Arg Tyr 
    130                 135                 140                 


Ile Ala Ile Val Gln Ala Thr Lys Ser Phe Arg Leu Arg Ser Arg Thr 
145                 150                 155                 160 


Leu Pro Arg Ser Lys Ile Ile Cys Leu Val Val Trp Gly Leu Ser Val 
                165                 170                 175     


Ile Ile Ser Ser Ser Thr Phe Val Phe Asn Gln Lys Tyr Asn Thr Gln 
            180                 185                 190         


Gly Ser Asp Val Cys Glu Pro Lys Tyr Gln Thr Val Ser Glu Pro Ile 
        195                 200                 205             


Arg Trp Lys Leu Leu Met Leu Gly Leu Glu Leu Leu Phe Gly Phe Phe 
    210                 215                 220                 


Ile Pro Leu Met Phe Met Ile Phe Cys Tyr Thr Phe Ile Val Lys Thr 
225                 230                 235                 240 


Leu Val Gln Ala Gln Asn Ser Lys Arg His Lys Ala Ile Arg Val Ile 
                245                 250                 255     


Ile Ala Val Val Leu Val Phe Leu Ala Cys Gln Ile Pro His Asn Met 
            260                 265                 270         


Val Leu Leu Val Thr Ala Ala Asn Leu Gly Lys Met Asn Arg Ser Cys 
        275                 280                 285             


Gln Ser Glu Lys Leu Ile Gly Tyr Thr Lys Thr Val Thr Glu Val Leu 
    290                 295                 300                 


Ala Phe Leu His Cys Cys Leu Asn Pro Val Leu Tyr Ala Phe Ile Gly 
305                 310                 315                 320 


Gln Lys Phe Arg Asn Tyr Phe Leu Lys Ile Leu Lys Asp Leu Trp Cys 
                325                 330                 335     


Val Arg Arg Lys Tyr Lys Ser Ser Gly Phe Ser Cys Ala Gly Arg Tyr 
            340                 345                 350         


Ser Glu Asn Ile Ser Arg Gln Thr Ser Glu Thr Ala Asp Asn Asp Asn 
        355                 360                 365             


Ala Ser Ser Phe Thr Met 
    370                 


<210>  72
<211>  367
<212>  PRT
<213>  Mus musculus

<400>  72

Met Asn Ser Thr Glu Ser Tyr Phe Gly Thr Asp Asp Tyr Asp Asn Thr 
1               5                   10                  15      


Glu Tyr Tyr Ser Ile Pro Pro Asp His Gly Pro Cys Ser Leu Glu Glu 
            20                  25                  30          


Val Arg Asn Phe Thr Lys Val Phe Val Pro Ile Ala Tyr Ser Leu Ile 
        35                  40                  45              


Cys Val Phe Gly Leu Leu Gly Asn Ile Met Val Val Met Thr Phe Ala 
    50                  55                  60                  


Phe Tyr Lys Lys Ala Arg Ser Met Thr Asp Val Tyr Leu Leu Asn Met 
65                  70                  75                  80  


Ala Ile Thr Asp Ile Leu Phe Val Leu Thr Leu Pro Phe Trp Ala Val 
                85                  90                  95      


Thr His Ala Thr Asn Thr Trp Val Phe Ser Asp Ala Leu Cys Lys Leu 
            100                 105                 110         


Met Lys Gly Thr Tyr Ala Val Asn Phe Asn Cys Gly Met Leu Leu Leu 
        115                 120                 125             


Ala Cys Ile Ser Met Asp Arg Tyr Ile Ala Ile Val Gln Ala Thr Lys 
    130                 135                 140                 


Ser Phe Arg Val Arg Ser Arg Thr Leu Thr His Ser Lys Val Ile Cys 
145                 150                 155                 160 


Val Ala Val Trp Phe Ile Ser Ile Ile Ile Ser Ser Pro Thr Phe Ile 
                165                 170                 175     


Phe Asn Lys Lys Tyr Glu Leu Gln Asp Arg Asp Val Cys Glu Pro Arg 
            180                 185                 190         


Tyr Arg Ser Val Ser Glu Pro Ile Thr Trp Lys Leu Leu Gly Met Gly 
        195                 200                 205             


Leu Glu Leu Phe Phe Gly Phe Phe Thr Pro Leu Leu Phe Met Val Phe 
    210                 215                 220                 


Cys Tyr Leu Phe Ile Ile Lys Thr Leu Val Gln Ala Gln Asn Ser Lys 
225                 230                 235                 240 


Arg His Arg Ala Ile Arg Val Val Ile Ala Val Val Leu Val Phe Leu 
                245                 250                 255     


Ala Cys Gln Ile Pro His Asn Met Val Leu Leu Val Thr Ala Val Asn 
            260                 265                 270         


Thr Gly Lys Val Gly Arg Ser Cys Ser Thr Glu Lys Val Leu Ala Tyr 
        275                 280                 285             


Thr Arg Asn Val Ala Glu Val Leu Ala Phe Leu His Cys Cys Leu Asn 
    290                 295                 300                 


Pro Val Leu Tyr Ala Phe Ile Gly Gln Lys Phe Arg Asn Tyr Phe Met 
305                 310                 315                 320 


Lys Ile Met Lys Asp Val Trp Cys Met Arg Arg Lys Asn Lys Met Pro 
                325                 330                 335     


Gly Phe Leu Cys Ala Arg Val Tyr Ser Glu Ser Tyr Ile Ser Arg Gln 
            340                 345                 350         


Thr Ser Glu Thr Val Glu Asn Asp Asn Ala Ser Ser Phe Thr Met 
        355                 360                 365         


<210>  73
<211>  366
<212>  PRT
<213>  Rattus rattus

<400>  73

Met Asn Phe Thr Glu Ala Asn Tyr Gly Met Glu Asp Tyr Thr Gly Ser 
1               5                   10                  15      


Asp Tyr Ser Met Phe Pro Glu Thr Glu Pro Cys Ser Leu Gln Glu Val 
            20                  25                  30          


Arg Asp Phe Thr Lys Val Phe Val Pro Ile Ala Tyr Ser Leu Ile Cys 
        35                  40                  45              


Val Phe Gly Leu Leu Gly Asn Ile Met Val Val Ile Thr Phe Ala Phe 
    50                  55                  60                  


Tyr Lys Lys Ala Arg Ser Met Thr Asp Val Tyr Leu Leu Asn Met Ala 
65                  70                  75                  80  


Ile Thr Asp Ile Leu Phe Val Leu Thr Leu Pro Phe Trp Ala Val Thr 
                85                  90                  95      


His Ala Thr Asp Thr Trp Ile Phe Gly Asn Thr Met Cys Lys Leu Met 
            100                 105                 110         


Lys Gly Thr Tyr Ala Val Asn Phe Asn Cys Gly Met Leu Leu Leu Ala 
        115                 120                 125             


Cys Ile Ser Met Asp Arg Tyr Ile Ala Ile Val Gln Ala Thr Lys Ser 
    130                 135                 140                 


Phe Arg Val Arg Ser Arg Thr Leu Thr His Ser Lys Val Ile Cys Leu 
145                 150                 155                 160 


Thr Val Trp Phe Val Ser Ile Ile Ile Ser Ser Pro Thr Phe Phe Phe 
                165                 170                 175     


Asn Lys Gln Tyr Lys Leu Gln Gly Arg Asp Val Cys Glu Pro Gln Tyr 
            180                 185                 190         


Lys Leu Val Ser Glu Pro Ile Thr Trp Lys Leu Leu Gly Met Gly Leu 
        195                 200                 205             


Glu Leu Leu Phe Gly Phe Phe Ile Pro Leu Leu Phe Met Val Phe Cys 
    210                 215                 220                 


Tyr Leu Phe Ile Ile Lys Thr Leu Val Gln Ala Gln Asn Ser Lys Arg 
225                 230                 235                 240 


His Arg Ala Ile Arg Val Val Ile Ala Val Val Leu Val Phe Leu Ala 
                245                 250                 255     


Cys Gln Ile Pro His Asn Met Val Leu Leu Val Thr Ala Ala Asn Thr 
            260                 265                 270         


Gly Lys Met Gly Arg Ser Cys Ser Ala Glu Lys Ala Leu Ala Tyr Ala 
        275                 280                 285             


Arg Asn Val Ala Glu Val Leu Ala Phe Leu His Cys Cys Leu Asn Pro 
    290                 295                 300                 


Val Leu Tyr Ala Phe Ile Gly Gln Lys Phe Arg Ser Tyr Phe Met Lys 
305                 310                 315                 320 


Ile Met Lys Asp Val Trp Cys Met Arg Arg Lys Ser Lys Val Pro Thr 
                325                 330                 335     


Phe Phe Cys Ala Arg Val Tyr Ser Glu Ser Tyr Ile Ser Arg Gln Thr 
            340                 345                 350         


Ser Glu Thr Val Glu Asn Asp Asn Ala Ser Ser Phe Thr Met 
        355                 360                 365     


<210>  74
<211>  374
<212>  PRT
<213>  Macaca mulatta

<400>  74

Met Ser Gly Glu Ser Met Asn Phe Ser Asp Val Phe Asp Ser Ser Glu 
1               5                   10                  15      


Asp Tyr Phe Ala Ser Val Asn Thr Ser Tyr Tyr Thr Val Asp Ser Glu 
            20                  25                  30          


Met Leu Leu Cys Thr Leu His Glu Val Arg Gln Phe Ser Arg Leu Phe 
        35                  40                  45              


Val Pro Ile Ala Tyr Ser Leu Ile Cys Val Phe Gly Leu Leu Gly Asn 
    50                  55                  60                  


Ile Leu Val Val Ile Thr Phe Ala Phe Tyr Lys Lys Ala Arg Ser Met 
65                  70                  75                  80  


Thr Asp Val Tyr Leu Leu Asn Met Ala Ile Ala Asp Ile Leu Phe Val 
                85                  90                  95      


Leu Thr Leu Pro Phe Trp Ala Val Ser His Ala Thr Gly Ala Trp Val 
            100                 105                 110         


Phe Ser Asn Ala Met Cys Lys Leu Met Lys Gly Ile Tyr Ala Ile Asn 
        115                 120                 125             


Phe Asn Cys Gly Met Leu Leu Leu Thr Cys Ile Ser Met Asp Arg Tyr 
    130                 135                 140                 


Ile Ala Ile Val Gln Ala Thr Lys Ser Phe Arg Leu Arg Tyr Arg Thr 
145                 150                 155                 160 


Leu Leu Arg Ser Lys Val Ile Cys Leu Ile Val Trp Gly Gly Ser Val 
                165                 170                 175     


Val Ile Ser Ser Ser Thr Phe Ile Phe Asn Gln Lys Tyr Asn Ile Gln 
            180                 185                 190         


Gly Ser Asp Val Cys Glu Pro Lys Tyr Gln Thr Val Ser Glu Pro Ile 
        195                 200                 205             


Lys Trp Lys Leu Leu Met Leu Gly Leu Glu Leu Leu Phe Gly Phe Phe 
    210                 215                 220                 


Ile Pro Leu Met Val Met Ile Phe Trp Tyr Met Phe Ile Val Lys Thr 
225                 230                 235                 240 


Leu Val Gln Ala Gln Asn Ser Lys Arg His Lys Ala Ile Arg Val Ile 
                245                 250                 255     


Ile Ala Val Val Leu Val Phe Leu Ala Cys Gln Ile Pro His Asn Met 
            260                 265                 270         


Val Leu Leu Val Thr Ala Ala Asn Leu Gly Asn Met Asn Arg Ser Cys 
        275                 280                 285             


His Ser Glu Lys Leu Leu Gly Tyr Thr Lys Thr Val Thr Glu Val Leu 
    290                 295                 300                 


Ala Phe Leu His Cys Cys Leu Asn Pro Val Leu Tyr Ala Phe Ile Gly 
305                 310                 315                 320 


Gln Lys Phe Arg Asn Tyr Phe Leu Lys Ile Met Lys Asp Leu Trp Cys 
                325                 330                 335     


Val Arg Arg Lys Tyr Lys Ser Ser Gly Phe Ser Cys Ala Gly Arg Tyr 
            340                 345                 350         


Ser Glu Asn Ile Ser Arg Gln Thr Ser Glu Thr Ala Asp Asn Asp Asn 
        355                 360                 365             


Ala Ser Ser Phe Thr Met 
    370                 


<210>  75
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH1 HC variable

<400>  75

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Thr Asn Gly Gly Ile Thr Tyr Tyr Pro Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  76
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Cys Cys Thr Lys Ser Leu Leu Leu Ala Ala Leu Met Ser Val Leu 
1               5                   10                  15      


Leu Leu His Leu Cys Gly Glu Ser Glu Ala Ala Ser Asn Phe Asp Cys 
            20                  25                  30          


Cys Leu Gly Tyr Thr Asp Arg Ile Leu His Pro Lys Phe Ile Val Gly 
        35                  40                  45              


Phe Thr Arg Gln Leu Ala Asn Glu Gly Cys Asp Ile Asn Ala Ile Ile 
    50                  55                  60                  


Phe His Thr Lys Lys Lys Leu Ser Val Cys Ala Asn Pro Lys Gln Thr 
65                  70                  75                  80  


Trp Val Lys Tyr Ile Val Arg Leu Leu Ser Lys Lys Val Lys Asn Met 
                85                  90                  95      


<210>  77
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  77

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  78
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  78

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  79
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  79

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  80
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  80

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys 
        


<210>  81
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  81

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg 
    


<210>  82
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  82

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro 
            100 


<210>  83
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  83

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro 
            100 


<210>  84
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  84

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Trp Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro 
            100 


<210>  85
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  85

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Val Ser Ser Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Ile His Leu Pro 
            100 


<210>  86
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  86

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Val Ser Ser Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Ile His Leu Pro 
            100 


<210>  87
<211>  720
<212>  DNA
<213>  Mus musculus

<400>  87
atggagagcc ctgcccagct gctgttcctg ctgctcctgt ggcttccgga cacccaggcc       60

gatgttataa tgacccagtc tccactctcc ctgcctgtca gtcttggaga tcaagcctcc      120

atctcttgca gatctagtca gagcattgta catagtaatg gaaacaccta tttagaatgg      180

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtctc caaccgattt      240

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      300

agcagagtgg aggctgagga tctgggactt tattactgct ttcaaggttc acatgttccg      360

ctcacgttcg gtgctgggac caagctggaa ataaaacgga ccgtggccgc tcccagcgtg      420

ttcatcttcc cccccagcga cgagcagctg aagagcggca ccgcctccgt ggtgtgcctg      480

ctgaacaact tctacccccg ggaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaaca gccaggaaag cgtcaccgag caggacagca aggactccac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggactgtc cagccccgtg accaagagct tcaacagggg cgagtgctga      720


<210>  88
<211>  1404
<212>  DNA
<213>  Mus musculus

<400>  88
atggagagcc ctgcccagct gctgttcctg ctgctcctgt ggcttccgga cacccaggcc       60

gaggtgaagc tggtggagtc tgggggaggc ttagtgcagc ctggagggtc cctgaaactc      120

tcctgtgcaa cttctggatt cagtttcagt gactattaca tgtattggat tcgccagact      180

ccagagaaga ggctggagtg ggtcgcatac attactaatg gtggtatcac ctattatcca      240

gacactgtaa agggccgatt caccatctcc agagacaatg ccaagaacac cctgtacctg      300

caaatgagcc gtctgaggtc tgaggacaca gccatgtatt actgtacaag tccattacgg      360

ggggcctggt ttgcttactg gggccaaggg actctggtca ctgtctcctc agcctccacc      420

aagggcccca gcgtgttccc cctggccccc agcagcaagt ctaccagcgg cggcacagca      480

gccctgggat gcctggtgaa ggactacttc cccgagcccg tgaccgtgag ctggaacagc      540

ggagccctga cctccggcgt gcacaccttc cccgccgtgc tgcagagcag cggcctgtac      600

agcctgagca gcgtggtgac cgtgcccagc agcagcctgg gcacccagac ctacatctgc      660

aacgtgaacc acaagcccag caacaccaag gtggacaaga aggtggagcc caagagctgc      720

gacaagaccc acacctgccc tccctgtcct gctcctgagc tgctcggcgg accctccgtg      780

ttcctgttcc cccccaagcc caaggacacc ctgatgatca gcaggacccc cgaggtgacc      840

tgcgtggtgg tggacgtgag ccacgaggac ccagaggtga agttcaactg gtacgtggac      900

ggcgtggagg tgcacaacgc caagaccaag cccagagagg aacagtacaa cagcacctac      960

agggtggtgt ccgtgctgac cgtgctgcac caggactggc tgaacggcaa agagtacaag     1020

tgcaaggtct ccaacaaggc cctgccagcc cccatcgaga aaaccatcag caaggccaag     1080

ggccagccac gggagcccca ggtgtacacc ctgcccccct cccgcgagga gatgaccaag     1140

aaccaggtgt ccctgacatg tctggtgaaa ggcttctacc ccagcgacat cgccgtggag     1200

tgggagagca acggccagcc cgagaacaac tacaagacca cccccccagt gctggacagc     1260

gacggcagct tcttcctgta cagcaagctg accgtggaca agagcaggtg gcagcagggc     1320

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagagc     1380

ctgagcctgt cccccggcaa gtga                                            1404


<210>  89
<211>  720
<212>  DNA
<213>  Mus musculus

<400>  89
atggagagcc ctgcccagct gctgttcctg ctgctcctgt ggcttccgga cacccaggcc       60

gatgttataa tgacccagtc tccactctcc ctgcctgtca gtcttggaga tcaagcctcc      120

atctcttgca gatctagtca gagcattgta catagtaatg gaaacaccta tttagaatgg      180

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtctc caaccgattt      240

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      300

agcagagtgg aggctgagga tctgggactt tattactgct ttcaaggttc acatgttccg      360

ctcacgttcg gtgctgggac caagctggaa ataaaacgga ccgtggccgc tcccagcgtg      420

ttcatcttcc cccccagcga cgagcagctg aagagcggca ccgcctccgt ggtgtgcctg      480

ctgaacaact tctacccccg ggaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaaca gccaggaaag cgtcaccgag caggacagca aggactccac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggactgtc cagccccgtg accaagagct tcaacagggg cgagtgctga      720


<210>  90
<211>  1407
<212>  DNA
<213>  Mus musculus

<400>  90
atggagagcc ctgcccagct gctgttcctg ctgctcctgt ggcttccgga cacccaggcc       60

gaggtgaagc tggtggagtc tgggggaggc ttagtgcagc ctggagggtc cctgaaactc      120

tcctgtgcaa cctctggatt cactttcagc gactattaca tgtattgggt tcgccagact      180

ccagagaaga ggctggagtg ggtcgcatac attactaatg gtgttggtaa cacctattat      240

ccagacactg taaagggccg attcaccatc tccagagaca atgccaagaa caccctgtac      300

ctgcaaatga gccgtctgaa gtctgaggac acagccatgt attactgtgc aagtccatta      360

cggggggcct ggtttgctta ctggggccaa gggactctgg tcactgtctc ctcagcctcc      420

accaagggcc ccagcgtgtt ccccctggcc cccagcagca agtctaccag cggcggcaca      480

gcagccctgg gatgcctggt gaaggactac ttccccgagc ccgtgaccgt gagctggaac      540

agcggagccc tgacctccgg cgtgcacacc ttccccgccg tgctgcagag cagcggcctg      600

tacagcctga gcagcgtggt gaccgtgccc agcagcagcc tgggcaccca gacctacatc      660

tgcaacgtga accacaagcc cagcaacacc aaggtggaca agaaggtgga gcccaagagc      720

tgcgacaaga cccacacctg ccctccctgt cctgctcctg agctgctcgg cggaccctcc      780

gtgttcctgt tcccccccaa gcccaaggac accctgatga tcagcaggac ccccgaggtg      840

acctgcgtgg tggtggacgt gagccacgag gacccagagg tgaagttcaa ctggtacgtg      900

gacggcgtgg aggtgcacaa cgccaagacc aagcccagag aggaacagta caacagcacc      960

tacagggtgg tgtccgtgct gaccgtgctg caccaggact ggctgaacgg caaagagtac     1020

aagtgcaagg tctccaacaa ggccctgcca gcccccatcg agaaaaccat cagcaaggcc     1080

aagggccagc cacgggagcc ccaggtgtac accctgcccc cctcccgcga ggagatgacc     1140

aagaaccagg tgtccctgac atgtctggtg aaaggcttct accccagcga catcgccgtg     1200

gagtgggaga gcaacggcca gcccgagaac aactacaaga ccaccccccc agtgctggac     1260

agcgacggca gcttcttcct gtacagcaag ctgaccgtgg acaagagcag gtggcagcag     1320

ggcaacgtgt tcagctgcag cgtgatgcac gaggccctgc acaaccacta cacccagaag     1380

agcctgagcc tgtcccccgg caagtga                                         1407


<210>  91
<211>  720
<212>  DNA
<213>  Mus musculus

<400>  91
atggagagcc ctgcccagct gctgttcctg ctgctcctgt ggcttccgga cacccaggcc       60

gatattgtac tcacccagtc tccactctcc ctgcctgtca gtcttggaga tcaagcctcc      120

atctcttgca gatctagtca gaacattgta catagtaatg gaaacactta tttagaatgg      180

tacctgcaga aaccaggcca gtctccgaag ctcctgatct acaaagtttc caaccgattt      240

tctggggttc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      300

agcagagtgg aggctgagga tctgggagtt tatttctgct ttcaaggttc acatgttccg      360

ctcacgttcg gtgctgggac caagctggaa ataaaacgga ccgtggccgc tcccagcgtg      420

ttcatcttcc cccccagcga cgagcagctg aagagcggca ccgcctccgt ggtgtgcctg      480

ctgaacaact tctacccccg ggaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaaca gccaggaaag cgtcaccgag caggacagca aggactccac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggactgtc cagccccgtg accaagagct tcaacagggg cgagtgctga      720


<210>  92
<211>  1407
<212>  DNA
<213>  Mus musculus

<400>  92
atggagagcc ctgcccagct gctgttcctg ctgctcctgt ggcttccgga cacccaggcc       60

gaggtgaagc tggtggagtc tgggggaggc ttagtgcagc ctggagggtc cctgaaactc      120

tcctgtacaa cctctggatt cactttcagt gactattata tgtattgggt tcgccagact      180

ccagagaaga ggctggagtg ggtcgcatac attactaatg gtgttggtaa tacctattat      240

ccaaacactg taaacggccg attcaccatc tccagagaca atgccaagaa cgccctgtac      300

ctgcaaatga gccgtctgaa gtctgaggac acagccatgt attactgtgc aagtccaata      360

cggggggcct ggtttgctta ctggggccaa gggactctgg tcactgtctc ctcagcctcc      420

accaagggcc ccagcgtgtt ccccctggcc cccagcagca agtctaccag cggcggcaca      480

gcagccctgg gatgcctggt gaaggactac ttccccgagc ccgtgaccgt gagctggaac      540

agcggagccc tgacctccgg cgtgcacacc ttccccgccg tgctgcagag cagcggcctg      600

tacagcctga gcagcgtggt gaccgtgccc agcagcagcc tgggcaccca gacctacatc      660

tgcaacgtga accacaagcc cagcaacacc aaggtggaca agaaggtgga gcccaagagc      720

tgcgacaaga cccacacctg ccctccctgt cctgctcctg agctgctcgg cggaccctcc      780

gtgttcctgt tcccccccaa gcccaaggac accctgatga tcagcaggac ccccgaggtg      840

acctgcgtgg tggtggacgt gagccacgag gacccagagg tgaagttcaa ctggtacgtg      900

gacggcgtgg aggtgcacaa cgccaagacc aagcccagag aggaacagta caacagcacc      960

tacagggtgg tgtccgtgct gaccgtgctg caccaggact ggctgaacgg caaagagtac     1020

aagtgcaagg tctccaacaa ggccctgcca gcccccatcg agaaaaccat cagcaaggcc     1080

aagggccagc cacgggagcc ccaggtgtac accctgcccc cctcccgcga ggagatgacc     1140

aagaaccagg tgtccctgac atgtctggtg aaaggcttct accccagcga catcgccgtg     1200

gagtgggaga gcaacggcca gcccgagaac aactacaaga ccaccccccc agtgctggac     1260

agcgacggca gcttcttcct gtacagcaag ctgaccgtgg acaagagcag gtggcagcag     1320

ggcaacgtgt tcagctgcag cgtgatgcac gaggccctgc acaaccacta cacccagaag     1380

agcctgagcc tgtcccccgg caagtga                                         1407


<210>  93
<211>  720
<212>  DNA
<213>  Mus musculus

<400>  93
atggagagcc ctgcccagct gctgttcctg ctgctcctgt ggcttccgga cacccaggcc       60

gatgttataa tgacccagtc tccactctcc ctgcctgtca gtcttggaga tcaagcctcc      120

atctcttgca gatctagtca gagcattgta catagtaatg gaaacaccta tttagaatgg      180

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtctc caaccgattt      240

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      300

agcagagtgg aggctgagga tctgggactt tattactgct ttcaaggttc acatgttccg      360

ctcacgttcg gtgctgggac caagctggaa ataaaacgga ccgtggccgc tcccagcgtg      420

ttcatcttcc cccccagcga cgagcagctg aagagcggca ccgcctccgt ggtgtgcctg      480

ctgaacaact tctacccccg ggaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaaca gccaggaaag cgtcaccgag caggacagca aggactccac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggactgtc cagccccgtg accaagagct tcaacagggg cgagtgctga      720


<210>  94
<211>  1407
<212>  DNA
<213>  Mus musculus

<400>  94
atggagagcc ctgcccagct gctgttcctg ctgctcctgt ggcttccgga cacccaggcc       60

gaggtgaagc tggtggaatc tgggggaggc ttagtgcagc ctggagggtc cctgaaactc      120

tcctgtgcaa cctctggatt ctctttcagt gactattaca tgtattgggt tcgccagact      180

ccagagaagg ggctggagtg ggtcgcatac attagtaatg gtgttggtaa cacctattat      240

ccagacactg taaagggccg attcaccatc tccagagaca atgccaagaa caccctgtac      300

ctgcaaatga gccgtctgaa gtctgaggac acagccatgt attactgtgc aagtccatta      360

cggggggcct ggtttgctta ctggggccaa gggactctgg tcactgtctc ctcagcctcc      420

accaagggcc ccagcgtgtt ccccctggcc cccagcagca agtctaccag cggcggcaca      480

gcagccctgg gatgcctggt gaaggactac ttccccgagc ccgtgaccgt gagctggaac      540

agcggagccc tgacctccgg cgtgcacacc ttccccgccg tgctgcagag cagcggcctg      600

tacagcctga gcagcgtggt gaccgtgccc agcagcagcc tgggcaccca gacctacatc      660

tgcaacgtga accacaagcc cagcaacacc aaggtggaca agaaggtgga gcccaagagc      720

tgcgacaaga cccacacctg ccctccctgt cctgctcctg agctgctcgg cggaccctcc      780

gtgttcctgt tcccccccaa gcccaaggac accctgatga tcagcaggac ccccgaggtg      840

acctgcgtgg tggtggacgt gagccacgag gacccagagg tgaagttcaa ctggtacgtg      900

gacggcgtgg aggtgcacaa cgccaagacc aagcccagag aggaacagta caacagcacc      960

tacagggtgg tgtccgtgct gaccgtgctg caccaggact ggctgaacgg caaagagtac     1020

aagtgcaagg tctccaacaa ggccctgcca gcccccatcg agaaaaccat cagcaaggcc     1080

aagggccagc cacgggagcc ccaggtgtac accctgcccc cctcccgcga ggagatgacc     1140

aagaaccagg tgtccctgac atgtctggtg aaaggcttct accccagcga catcgccgtg     1200

gagtgggaga gcaacggcca gcccgagaac aactacaaga ccaccccccc agtgctggac     1260

agcgacggca gcttcttcct gtacagcaag ctgaccgtgg acaagagcag gtggcagcag     1320

ggcaacgtgt tcagctgcag cgtgatgcac gaggccctgc acaaccacta cacccagaag     1380

agcctgagcc tgtcccccgg caagtga                                         1407


<210>  95
<211>  720
<212>  DNA
<213>  Mus musculus

<400>  95
atggagagcc ctgcccagct gctgttcctg ctgctcctgt ggcttccgga cacccaggcc       60

gatgttataa tgacccagtc tccactctcc ctgcctgtca gtcttggaga tcaagcctcc      120

atctcttgca gatctagtca gagcattgta catagtaatg gaaacaccta tttagaatgg      180

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtctc caaccgattt      240

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      300

agcagagtgg aggctgagga tctgggactt tattactgct ttcaaggttc acatgttccg      360

ctcacgttcg gtgctgggac caagctggaa ataaaacgga ccgtggccgc tcccagcgtg      420

ttcatcttcc cccccagcga cgagcagctg aagagcggca ccgcctccgt ggtgtgcctg      480

ctgaacaact tctacccccg ggaggccaag gtgcagtgga aggtggacaa cgccctgcag      540

agcggcaaca gccaggaaag cgtcaccgag caggacagca aggactccac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggactgtc cagccccgtg accaagagct tcaacagggg cgagtgctga      720


<210>  96
<211>  1407
<212>  DNA
<213>  Mus musculus

<400>  96
atggagagcc ctgcccagct gctgttcctg ctgctcctgt ggcttccgga cacccaggcc       60

gaggtgaagc tggtggagtc tgggggaggc ttagtgcagc ctggagggtc cctgaaactc      120

tcctgtgcaa cctctggatt cactttcagt gactattaca tgtattgggt tcgccagact      180

ccagagagga ggctggagtg ggtcgcatac attactaatg atgttggtaa aacctattat      240

tcagacactg taaagggccg attcaccatc tccagagata atgccaagaa caccctgtac      300

ctacaaatga gtcgtctgaa gtctgaggac acagccatgt attactgtgc aagtccaata      360

cggggggcct ggtttgctta ctggggccaa gggactctgg tcactgtctc ctcagcctcc      420

accaagggcc ccagcgtgtt ccccctggcc cccagcagca agtctaccag cggcggcaca      480

gcagccctgg gatgcctggt gaaggactac ttccccgagc ccgtgaccgt gagctggaac      540

agcggagccc tgacctccgg cgtgcacacc ttccccgccg tgctgcagag cagcggcctg      600

tacagcctga gcagcgtggt gaccgtgccc agcagcagcc tgggcaccca gacctacatc      660

tgcaacgtga accacaagcc cagcaacacc aaggtggaca agaaggtgga gcccaagagc      720

tgcgacaaga cccacacctg ccctccctgt cctgctcctg agctgctcgg cggaccctcc      780

gtgttcctgt tcccccccaa gcccaaggac accctgatga tcagcaggac ccccgaggtg      840

acctgcgtgg tggtggacgt gagccacgag gacccagagg tgaagttcaa ctggtacgtg      900

gacggcgtgg aggtgcacaa cgccaagacc aagcccagag aggaacagta caacagcacc      960

tacagggtgg tgtccgtgct gaccgtgctg caccaggact ggctgaacgg caaagagtac     1020

aagtgcaagg tctccaacaa ggccctgcca gcccccatcg agaaaaccat cagcaaggcc     1080

aagggccagc cacgggagcc ccaggtgtac accctgcccc cctcccgcga ggagatgacc     1140

aagaaccagg tgtccctgac atgtctggtg aaaggcttct accccagcga catcgccgtg     1200

gagtgggaga gcaacggcca gcccgagaac aactacaaga ccaccccccc agtgctggac     1260

agcgacggca gcttcttcct gtacagcaag ctgaccgtgg acaagagcag gtggcagcag     1320

ggcaacgtgt tcagctgcag cgtgatgcac gaggccctgc acaaccacta cacccagaag     1380

agcctgagcc tgtcccccgg caagtga                                         1407


<210>  97
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4H11 VL1 LC Nucleotide

<400>  97
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg atccactggt       60

gatgtcgtga tgacccagag ccccctgagc ctgcctgtga cactgggaca gcctgccagc      120

atcagctgca gatccagcca gagcatcgtg cacagcaacg gcaataccta tctggaatgg      180

tatcagcagc ggcctggcca gtcccccaga ctgctgatct acaaggtgtc caaccggttc      240

agcggcgtgc ccgacagatt ttctggctct ggcagcggca ccgacttcac cctgaagatc      300

tcccgggtgg aagccgagga cgtgggcgtg tactactgtt ttcaaggcag ccacgtgccc      360

ctgaccttcg gccagggaac aaagctggaa atcaagcgta cggtggccgc tcccagcgtg      420

ttcatcttcc cccccagcga cgagcagctg aagagcggca ccgcctccgt ggtgtgcctg      480

ctgaacaact tctacccccg ggaggccaag gtgcagtgga aggtggacaa cgccctccag      540

agcggcaaca gccaggaaag cgtcaccgag caggacagca aggactccac ctacagcctg      600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      660

gtgacccacc agggcctgtc cagccccgtg accaagagct tcaaccgggg cgagtgctga      720

taa                                                                    723


<210>  98
<211>  1398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4H11 VH5 IgG4 S228P Nucleotide

<400>  98
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg atccactggt       60

gaagtgcagc tggtggaatc tggcggcgga ctggtgcagc ctggcggatc tctgagactg      120

agctgtgccg ccagcggctt cagcttcagc gactactaca tgtactgggt gcgccaggcc      180

cctggcaagg gactggaatg ggtgtcctac atcaccaacg gcggcatcac ctactacccc      240

gactccgtga agggccggtt caccatcagc cgggacaaca gcaagaacac cctgtacctg      300

cagatgaaca gcctgcgggc cgaggacacc gccgtgtact actgtaccag ccccctgaga      360

ggcgcttggt ttgcctattg gggccagggc accctcgtga ccgtgtctag tgcgtcgacc      420

aagggcccca gcgtgttccc cctggccccc tgcagcagaa gcaccagcga gtccacagcc      480

gccctgggct gtctggtgaa ggactacttc cccgagcccg tgaccgtgtc ctggaacagc      540

ggagccctga ccagcggcgt gcacaccttc cccgccgtgc tgcagagcag cggcctgtac      600

agcctgagca gcgtggtgac agtgcccagc agcagcctgg gcaccaagac ctacacctgc      660

aacgtggacc acaagcccag caacaccaag gtggacaaga gggtggagag caagtacggc      720

ccaccctgcc ccccatgccc agcccccgag ttcctgggcg gaccctccgt gttcctgttc      780

ccccccaagc ccaaggacac cctgatgatc agcaggaccc ccgaggtgac ctgcgtggtg      840

gtggacgtga gccaggagga cccagaggtc cagttcaact ggtacgtgga cggcgtggag      900

gtgcacaacg ccaagaccaa gcccagagag gagcagttta acagcaccta cagggtggtg      960

tccgtgctga ccgtgctgca ccaggactgg ctgaacggca aggaatacaa gtgcaaggtc     1020

tccaacaagg gcctgcccag ctccatcgag aaaaccatca gcaaggccaa gggccagcca     1080

cgggagcccc aggtgtacac cctgccaccc tcccaggagg agatgaccaa gaaccaggtg     1140

tccctgacct gcctggtgaa gggcttctac cccagcgaca tcgccgtgga gtgggagagc     1200

aacggccagc ccgagaacaa ctacaagacc acccccccag tgctggacag cgacggcagc     1260

ttcttcctgt acagcaggct gaccgtggac aagtccaggt ggcaggaggg caacgtcttt     1320

agctgcagcg tgatgcacga ggccctgcac aaccactaca cccagaagag cctgagcctg     1380

tccctgggca agtgatag                                                   1398


<210>  99
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  99
gaggctagcc accatgagcg gggaatcaat gaa                                    33


<210>  100
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  100
aggggcatcg attcacatag tgaaggacga cgc                                    33


<210>  101
<211>  1126
<212>  DNA
<213>  Homo sapiens

<400>  101
atgagcgggg aatcaatgaa tttcagcgat gttttcgact ccagtgaaga ttattttgtg       60

tcagtcaata cttcatatta ctcagttgat tctgagatgt tactgtgctc cttgcaggag      120

gtcaggcagt tctccaggct atttgtaccg attgcctact ccttgatctg tgtctttggc      180

ctcctgggga atattctggt ggtgatcacc tttgcttttt ataagaaggc caggtctatg      240

acagacgtct atctcttgaa catggccatt gcagacatcc tctttgttct tactctccca      300

ttctgggcag tgagtcatgc caccggtgcg tgggttttca gcaatgccac gtgcaagttg      360

ctaaaaggca tctatgccat caactttaac tgcgggatgc tgctcctgac ttgcattagc      420

atggaccggt acatcgccat tgtacaggcg actaagtcat tccggctccg atccagaaca      480

ctaccgcgca gcaaaatcat ctgccttgtt gtgtgggggc tgtcagtcat catctccagc      540

tcaacttttg tcttcaacca aaaatacaac acccaaggca gcgatgtctg tgaacccaag      600

taccagactg tctcggagcc catcaggtgg aagctgctga tgttggggct tgagctactc      660

tttggtttct ttatcccttt gatgttcatg atattttgtt acacgttcat tgtcaaaacc      720

ttggtgcaag ctcagaattc taaaaggcac aaagccatcc gtgtaatcat agctgtggtg      780

cttgtgtttc tggcttgtca gattcctcat aacatggtcc tgcttgtgac ggctgcaaat      840

ttgggtaaaa tgaaccgatc ctgccagagc gaaaagctaa ttggctatac gaaaactgtc      900

acagaagtcc tggctttcct gcactgctgc ctgaaccctg tgctctacgc ttttattggg      960

cagaagttca gaaactactt tctgaagatc ttgaaggacc tgtggtgtgt gagaaggaag     1020

tacaagtcct caggcttctc ctgtgccggg aggtactcag aaaacatttc tcggcagacc     1080

agtgagaccg cagataacga caatgcgtcg tccttcacta tgtgaa                    1126


<210>  102
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  102
gtgatcgcca tggcgtcgac cgakgtrmag cttcaggagt c                           41


<210>  103
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  103
gtgatcgcca tggcgtcgac cgaggtbcag ctbcagcagt c                           41


<210>  104
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  104
gtgatcgcca tggcgtcgac ccaggtgcag ctgaagsart c                           41


<210>  105
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  105
gtgatcgcca tggcgtcgac cgaggtccar ctgcaacart c                           41


<210>  106
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  106
gtgatcgcca tggcgtcgac ccaggtycag ctbcagcart c                           41


<210>  107
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  107
gtgatcgcca tggcgtcgac ccaggtycar ctgcagcart c                           41


<210>  108
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  108
gtgatcgcca tggcgtcgac ccaggtccac gtgaagcart c                           41


<210>  109
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  109
gtgatcgcca tggcgtcgac cgaggtgaas stggtggart c                           41


<210>  110
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  110
gtgatcgcca tggcgtcgac cgavgtgawg stggtggagt c                           41


<210>  111
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  111
gtgatcgcca tggcgtcgac cgaggtgcag stggtggart c                           41


<210>  112
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  112
gtgatcgcca tggcgtcgac cgakgtgcam ctggtggart c                           41


<210>  113
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  113
gtgatcgcca tggcgtcgac cgaggtgaag ctgatggart c                           41


<210>  114
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  114
gtgatcgcca tggcgtcgac cgaggtgcar cttgttgart c                           41


<210>  115
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  115
gtgatcgcca tggcgtcgac cgargtraag cttctcgart c                           41


<210>  116
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  116
gtgatcgcca tggcgtcgac cgaagtgaar sttgaggart c                           41


<210>  117
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  117
gtgatcgcca tggcgtcgac ccaggttact ctraaasart c                           41


<210>  118
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  118
gtgatcgcca tggcgtcgac ccaggtccaa ctvcagcarc c                           41


<210>  119
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  119
gtgatcgcca tggcgtcgac cgatgtgaac ttggaasart c                           41


<210>  120
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  120
gtgatcgcca tggcgtcgac cgaggtgaag gtcatcgart c                           41


<210>  121
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  121
cctccaccac tcgagcccga ggaaacggtg accgtggt                               38


<210>  122
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  122
cctccaccac tcgagcccga ggagactgtg agagtggt                               38


<210>  123
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  123
cctccaccac tcgagcccgc agagacagtg accagagt                               38


<210>  124
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  124
cctccaccac tcgagcccga ggagacggtg actgaggt                               38


<210>  125
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  125
ggcggtggcg ctagcgayat ccagctgact cagcc                                  35


<210>  126
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  126
ggcggtggcg ctagccaaat tgttctcacc cagtc                                  35


<210>  127
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  127
ggcggtggcg ctagcgayat tgtgmtmact cagtc                                  35


<210>  128
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  128
ggcggtggcg ctagcgayat tgtgytraca cagtc                                  35


<210>  129
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  129
ggcggtggcg ctagcgayat tgtratgacm cagtc                                  35


<210>  130
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  130
ggcggtggcg ctagcgayat tmagatramc cagtc                                  35


<210>  131
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  131
ggcggtggcg ctagcgayat tcagatgayd cagtc                                  35


<210>  132
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  132
ggcggtggcg ctagcgayat ycagatgaca cagac                                  35


<210>  133
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  133
ggcggtggcg ctagcgayat tgttctcawc cagtc                                  35


<210>  134
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  134
ggcggtggcg ctagcgayat tgwgctsacc caatc                                  35


<210>  135
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  135
ggcggtggcg ctagcgayat tstratgacc cartc                                  35


<210>  136
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  136
ggcggtggcg ctagcgayrt tktgatgacc carac                                  35


<210>  137
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  137
ggcggtggcg ctagcgayat tgtgatgacb cagkc                                  35


<210>  138
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  138
ggcggtggcg ctagcgayat tgtgataacy cagga                                  35


<210>  139
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  139
ggcggtggcg ctagcgayat tgtgatgacc cagwt                                  35


<210>  140
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  140
ggcggtggcg ctagcgayat tgtgatgaca caacc                                  35


<210>  141
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  141
ggcggtggcg ctagcgayat tttgctgact cagtc                                  35


<210>  142
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  142
ggcggtggcg ctagcgaaac aactgtgacc cagtc                                  35


<210>  143
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  143
ggcggtggcg ctagcgaaaa tgtkctsacc cagtc                                  35


<210>  144
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  144
ggcggtggcg ctagccaggc tgttgtgact caggaatc                               38


<210>  145
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  145
atgctgacgc ggccgcacgt ttkatttcca gcttgg                                 36


<210>  146
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  146
atgctgacgc ggccgcacgt tttatttcca actttg                                 36


<210>  147
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  147
atgctgacgc ggccgcacgt ttcagctcca gcttgg                                 36


<210>  148
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  148
atgctgacgc ggccgcacct aggacagtca gtttgg                                 36


<210>  149
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  149
gtaaaacgac ggccagt                                                      17


<210>  150
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  150
aacagctatg accatg                                                       16


<210>  151
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  151
taatacgact cactatagg                                                    19


<210>  152
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  152
gatttaggtg acactatag                                                    19


<210>  153
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  153
gatcgctagc caccatgagc ggggaatcaa tgaa                                   34


<210>  154
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  154
gatcctcgag tcatcacata gtgaaggacg acg                                    33


<210>  155
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  155
catcgctgaa aacccaagtg ttggtggcat gagtcactgc ccagaatggg agagtaag         58


<210>  156
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  156
aacacttggg ttttcagcga tgcactgtgt aaattgctaa aaggcatcta tgccatca         58


<210>  157
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  157
ctcacagaca tcacgatcct gcagctcgta tttcttgttg aagataaatg tagggctgga       60

gatgatgact gacagccccc ac                                                82


<210>  158
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  158
gatcgtgatg tctgtgagcc acggtacagg tctgtctcag agcccatcac gtggaagctg       60

ctgatgttgg ggcttgagct ac                                                82


<210>  159
<211>  71
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  159
cgaggacttt ctcggtgctg cagctccggc ccactttgcc cgtgtttgca gccgtcacaa       60

gcaggaccat g                                                            71


<210>  160
<211>  71
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  160
gcaccgagaa agtcctcgcc tacaccagga acgtggccga ggtcctggct ttcctgcact       60

gctgcctgaa c                                                            71


<210>  161
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  161
agaggctagc caccatgaat tccacagagt ccta                                   34


<210>  162
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  162
caaggagtag gcaatcggta caaatacctt ggtgaagttt ctgac                       45


<210>  163
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  163
aaacttcacc aaggtatttg taccgattgc ctactccttg atctg                       45


<210>  164
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  164
caattggcac aaatagcctg gagaactgcc tgacctcctg                             40


<210>  165
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  165
tcaggcagtt ctccaggcta tttgtgccaa ttgcctactc                             40


<210>  166
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  166
ccgcgatcct cgagtcatta catggtaaag gacgatgcat tatca                       45


<210>  167
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFvformatcDNAof4H11VH1andVL1

<400>  167
gaagtgcagc tggtggaatc tggcggcgga ctggtgcagc ctggcggatc tctgagactg       60

agctgtgcca ccagcggctt cagcttcagc gactactaca tgtactgggt gcgccaggcc      120

cctggcaagg gactggaatg ggtggcctac atcaccaacg gcggcatcac ctactacccc      180

gacaccgtga agggccggtt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgcgggc cgaggacacc gccgtgtact actgtaccag ccccctgaga      300

ggcgcttggt ttgcctattg gggccagggc accaccgtga ccgtgtctag tggaggcgga      360

ggatctggcg gcggaggaag tggcggaggg ggatctgggg gaggcggatc tgatgtcgtg      420

atgacccaga gccccctgag cctgcctgtg acactgggac agcctgccag catcagctgc      480

agatccagcc agagcatcgt gcacagcaac ggcaatacct atctggaatg gtatcagcag      540

cggcctggcc agtcccccag actgctgatc tacaaggtgt ccaaccggtt cagcggcgtg      600

cccgacagat tttctggctc tggcagcggc accgacttca ccctgaagat ctcccgggtg      660

gaagccgagg acgtgggcgt gtactactgt tttcaaggca gccacgtgcc cctgaccttc      720

ggccagggaa caaagctgga aatcaag                                          747


<210>  168
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hsCCR6-mmNterm

<400>  168

Met Asn Ser Thr Glu Ser Tyr Phe Gly Thr Asp Asp Tyr Asp Asn Thr 
1               5                   10                  15      


Glu Tyr Tyr Ser Ile Pro Pro Asp His Gly Pro Cys Ser Leu Glu Glu 
            20                  25                  30          


Val Arg Asn Phe Thr Lys Val Phe Val Pro Ile Ala Tyr Ser Leu Ile 
        35                  40                  45              


Cys Val Phe Gly Leu Leu Gly Asn Ile Leu Val Val Ile Thr Phe Ala 
    50                  55                  60                  


Phe Tyr Lys Lys Ala Arg Ser Met Thr Asp Val Tyr Leu Leu Asn Met 
65                  70                  75                  80  


Ala Ile Ala Asp Ile Leu Phe Val Leu Thr Leu Pro Phe Trp Ala Val 
                85                  90                  95      


Ser His Ala Thr Gly Ala Trp Val Phe Ser Asn Ala Thr Cys Lys Leu 
            100                 105                 110         


Leu Lys Gly Ile Tyr Ala Ile Asn Phe Asn Cys Gly Met Leu Leu Leu 
        115                 120                 125             


Thr Cys Ile Ser Met Asp Arg Tyr Ile Ala Ile Val Gln Ala Thr Lys 
    130                 135                 140                 


Ser Phe Arg Leu Arg Ser Arg Thr Leu Pro Arg Ser Lys Ile Ile Cys 
145                 150                 155                 160 


Leu Val Val Trp Gly Leu Ser Val Ile Ile Ser Ser Ser Thr Phe Val 
                165                 170                 175     


Phe Asn Gln Lys Tyr Asn Thr Gln Gly Ser Asp Val Cys Glu Pro Lys 
            180                 185                 190         


Tyr Gln Thr Val Ser Glu Pro Ile Arg Trp Lys Leu Leu Met Leu Gly 
        195                 200                 205             


Leu Glu Leu Leu Phe Gly Phe Phe Ile Pro Leu Met Phe Met Ile Phe 
    210                 215                 220                 


Cys Tyr Thr Phe Ile Val Lys Thr Leu Val Gln Ala Gln Asn Ser Lys 
225                 230                 235                 240 


Arg His Lys Ala Ile Arg Val Ile Ile Ala Val Val Leu Val Phe Leu 
                245                 250                 255     


Ala Cys Gln Ile Pro His Asn Met Val Leu Leu Val Thr Ala Ala Asn 
            260                 265                 270         


Leu Gly Lys Met Asn Arg Ser Cys Gln Ser Glu Lys Leu Ile Gly Tyr 
        275                 280                 285             


Thr Lys Thr Val Thr Glu Val Leu Ala Phe Leu His Cys Cys Leu Asn 
    290                 295                 300                 


Pro Val Leu Tyr Ala Phe Ile Gly Gln Lys Phe Arg Asn Tyr Phe Leu 
305                 310                 315                 320 


Lys Ile Leu Lys Asp Leu Trp Cys Val Arg Arg Lys Tyr Lys Ser Ser 
                325                 330                 335     


Gly Phe Ser Cys Ala Gly Arg Tyr Ser Glu Asn Ile Ser Arg Gln Thr 
            340                 345                 350         


Ser Glu Thr Ala Asp Asn Asp Asn Ala Ser Ser Phe Thr Met 
        355                 360                 365     


<210>  169
<211>  1101
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hsCCR6-mmNtermDNA

<400>  169
atgaattcca cagagtccta ctttggaacg gatgattatg acaacacaga gtattattct       60

attcctccag accatgggcc atgctcccta gaagaggtca gaaacttcac caaggtattt      120

gtaccgattg cctactcctt gatctgtgtc tttggcctcc tggggaatat tctggtggtg      180

atcacctttg ctttttataa gaaggccagg tctatgacag acgtctatct cttgaacatg      240

gccattgcag acatcctctt tgttcttact ctcccattct gggcagtgag tcatgccact      300

ggtgcgtggg ttttcagcaa tgccacgtgc aagttgctaa aaggcatcta tgccatcaac      360

tttaactgcg ggatgctgct cctgacttgc attagcatgg accggtacat cgccattgta      420

caggcgacta agtcattccg gctccgatcc agaacactac cgcgcagcaa aatcatctgc      480

cttgttgtgt gggggctgtc agtcatcatc tccagctcaa cttttgtctt caaccaaaaa      540

tacaacaccc aaggcagcga tgtctgtgaa cccaagtacc agactgtctc ggagcccatc      600

aggtggaagc tgctgatgtt ggggcttgag ctactctttg gtttctttat ccctttgatg      660

ttcatgatat tttgttacac gttcattgtc aaaaccttgg tgcaagctca gaattctaaa      720

aggcacaaag ccatccgtgt aatcatagct gtggtgcttg tgtttctggc ttgtcagatt      780

cctcataaca tggtcctgct tgtgacggct gcaaatttgg gtaaaatgaa ccgatcctgc      840

cagagcgaaa agctaattgg ctatacgaaa actgtcacag aagtcctggc tttcctgcac      900

tgctgcctga accctgtgct ctacgctttt attgggcaga agttcagaaa ctactttctg      960

aagatcttga aggacctgtg gtgtgtgaga aggaagtaca agtcctcagg cttctcctgt     1020

gccgggaggt actcagaaaa catttctcgg cagaccagtg agaccgcaga taacgacaat     1080

gcgtcgtcct tcactatgtg a                                               1101


<210>  170
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mmCCR6-hsNterm

<400>  170

Met Ser Gly Glu Ser Met Asn Phe Ser Asp Val Phe Asp Ser Ser Glu 
1               5                   10                  15      


Asp Tyr Phe Val Ser Val Asn Thr Ser Tyr Tyr Ser Val Asp Ser Glu 
            20                  25                  30          


Met Leu Leu Cys Ser Leu Gln Glu Val Arg Gln Phe Ser Arg Leu Phe 
        35                  40                  45              


Val Pro Ile Ala Tyr Ser Leu Ile Cys Val Phe Gly Leu Leu Gly Asn 
    50                  55                  60                  


Ile Met Val Val Met Thr Phe Ala Phe Tyr Lys Lys Ala Arg Ser Met 
65                  70                  75                  80  


Thr Asp Val Tyr Leu Leu Asn Met Ala Ile Thr Asp Ile Leu Phe Val 
                85                  90                  95      


Leu Thr Leu Pro Phe Trp Ala Val Thr His Ala Thr Asn Thr Trp Val 
            100                 105                 110         


Phe Ser Asp Ala Leu Cys Lys Leu Met Lys Gly Thr Tyr Ala Val Asn 
        115                 120                 125             


Phe Asn Cys Gly Met Leu Leu Leu Ala Cys Ile Ser Met Asp Arg Tyr 
    130                 135                 140                 


Ile Ala Ile Val Gln Ala Thr Lys Ser Phe Arg Val Arg Ser Arg Thr 
145                 150                 155                 160 


Leu Thr His Ser Lys Val Ile Cys Val Ala Val Trp Phe Ile Ser Ile 
                165                 170                 175     


Ile Ile Ser Ser Pro Thr Phe Ile Phe Asn Lys Lys Tyr Glu Leu Gln 
            180                 185                 190         


Asp Arg Asp Val Cys Glu Pro Arg Tyr Arg Ser Val Ser Glu Pro Ile 
        195                 200                 205             


Thr Trp Lys Leu Leu Gly Met Gly Leu Glu Leu Phe Phe Gly Phe Phe 
    210                 215                 220                 


Thr Pro Leu Leu Phe Met Val Phe Cys Tyr Leu Phe Ile Ile Lys Thr 
225                 230                 235                 240 


Leu Val Gln Ala Gln Asn Ser Lys Arg His Arg Ala Ile Arg Val Val 
                245                 250                 255     


Ile Ala Val Val Leu Val Phe Leu Ala Cys Gln Ile Pro His Asn Met 
            260                 265                 270         


Val Leu Leu Val Thr Ala Val Asn Thr Gly Lys Val Gly Arg Ser Cys 
        275                 280                 285             


Ser Thr Glu Lys Val Leu Ala Tyr Thr Arg Asn Val Ala Glu Val Leu 
    290                 295                 300                 


Ala Phe Leu His Cys Cys Leu Asn Pro Val Leu Tyr Ala Phe Ile Gly 
305                 310                 315                 320 


Gln Lys Phe Arg Asn Tyr Phe Met Lys Ile Met Lys Asp Val Trp Cys 
                325                 330                 335     


Met Arg Arg Lys Asn Lys Met Pro Gly Phe Leu Cys Ala Arg Val Tyr 
            340                 345                 350         


Ser Glu Ser Tyr Ile Ser Arg Gln Thr Ser Glu Thr Val Glu Asn Asp 
        355                 360                 365             


Asn Ala Ser Ser Phe Thr Met 
    370                 375 


<210>  171
<211>  1128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mmCCR6-hsNtermDNA

<400>  171
atgagcgggg aatcaatgaa tttcagcgat gttttcgact ccagtgaaga ttattttgtg       60

tcagtcaata cttcatatta ctcagttgat tctgagatgt tactgtgctc cttgcaggag      120

gtcaggcagt tctccaggct atttgtgcca attgcctact ccttaatatg tgtctttggc      180

ctcctgggca acattatggt ggtgatgacc tttgccttct acaagaaagc cagatccatg      240

actgacgtct acctgttgaa catggccatc acagacatac tctttgtcct caccctaccg      300

ttctgggcag ttactcatgc caccaacact tgggttttca gcgatgcact gtgtaaactg      360

atgaaaggca catatgcggt caactttaac tgtgggatgc tgctcctggc ctgtatcagc      420

atggaccggt acattgccat cgtccaggca accaaatctt tccgggtacg ctccagaaca      480

ctgacgcaca gtaaggtcat ctgtgtggca gtgtggttca tctccatcat catctcaagc      540

cctacattta tcttcaacaa gaaatacgag ctgcaggatc gtgatgtctg tgagccacgg      600

tacaggtctg tctcagagcc catcacgtgg aagctgctgg gtatgggact ggagctgttc      660

tttgggttct tcaccccttt gctgtttatg gtgttctgct atctgttcat tatcaagacc      720

ttggtgcagg cccagaactc caagaggcac agagccatcc gagtcgtgat cgctgtggtt      780

ctcgtgttcc tggcttgtca gatccctcac aacatggtcc tcctcgtgac tgcggtcaac      840

acgggcaaag tgggccggag ctgcagcacc gagaaagtcc tcgcctacac caggaacgtg      900

gccgaggtcc tggctttcct gcattgctgc ctcaaccccg tgttgtatgc gtttattgga      960

cagaaattca gaaactactt catgaagatc atgaaggatg tgtggtgtat gagaaggaag     1020

aataagatgc ctggcttcct ctgtgcccgg gtttactcgg aaagctacat ctccaggcag     1080

accagtgaga ccgtcgaaaa tgataatgca tcgtccttta ccatgtaa                  1128


<210>  172
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hsCCR6 N-terminal sequence

<400>  172

Met Asn Phe Ser Asp Val Phe Asp Ser Ser Glu Asp Tyr Asp Asn Thr 
1               5                   10                  15      


Glu Tyr Tyr Ser Val Asp Ser Glu Met Leu Leu Cys Ser Leu Gly Glu 
            20                  25                  30          


Val Arg Gln Phe Ser Arg Leu 
        35                  


<210>  173
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H11 VH1 heavy chain IgG1

<400>  173

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Thr Asn Gly Gly Ile Thr Tyr Tyr Pro Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  174
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mmCCR6Nterminalsequence

<400>  174

Met Asn Ser Thr Glu Ser Tyr Phe Gly Thr Asp Asp Tyr Asp Asn Thr 
1               5                   10                  15      


Glu Tyr Tyr Ser Ile Pro Pro Asp His Gly Pro Cys Ser Leu Gly Glu 
            20                  25                  30          


Val Arg Gln Phe Ser Arg Leu 
        35                  


<210>  175
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimera 4H11 heavy chain IgG1

<400>  175

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Ile Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Thr Asn Gly Gly Ile Thr Tyr Tyr Pro Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Arg Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  176
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimera 4H11 light chain

<400>  176

Asp Val Ile Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  177
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H11 VH2

<400>  177

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Thr Asn Gly Gly Ile Thr Tyr Tyr Pro Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  178
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H11 VH3

<400>  178

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Asn Gly Gly Ile Thr Tyr Tyr Pro Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  179
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H11 VH4

<400>  179

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Asn Gly Gly Ile Thr Tyr Tyr Pro Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  180
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutantmmCCR6block1hsCCR6

<400>  180

Met Asn Phe Ser Asp Val Phe Asp Ser Ser Glu Asp Tyr Asp Asn Thr 
1               5                   10                  15      


Glu Tyr Tyr Ser Ile Pro Pro Asp His Gly Pro Cys Ser Leu Glu Glu 
            20                  25                  30          


Val Arg Asn Phe Thr Lys Val 
        35                  


<210>  181
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H11 VL2

<400>  181

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  182
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H11 VL3

<400>  182

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  183
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  411VH2heavychainIgG1

<400>  183

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Thr Asn Gly Gly Ile Thr Tyr Tyr Pro Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  184
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH3 heavy chain IgG1

<400>  184

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Asn Gly Gly Ile Thr Tyr Tyr Pro Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  185
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutantmmCCR6block2hsCCR6

<400>  185

Met Asn Ser Thr Glu Ser Tyr Phe Gly Thr Asp Asp Tyr Asp Asn Thr 
1               5                   10                  15      


Glu Tyr Tyr Ser Val Asp Ser Glu Met Leu Leu Cys Ser Leu Glu Glu 
            20                  25                  30          


Val Arg Asn Phe Thr Lys Val 
        35                  


<210>  186
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H11 VL2 light chain

<400>  186

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  187
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H11 VL3 light chain

<400>  187

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  188
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human CCR6-Fc

<400>  188

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Met Ser Gly Glu Ser Met Asn Phe Ser Asp Val Phe 
            20                  25                  30          


Asp Ser Ser Glu Asp Tyr Phe Val Ser Val Asn Thr Ser Tyr Tyr Ser 
        35                  40                  45              


Val Asp Ser Glu Met Leu Leu Cys Ser Leu Gln Glu Val Arg Gln Phe 
    50                  55                  60                  


Ser Arg Leu Gly Gly Gly Gly Thr Asp Lys Thr His Thr Cys Pro Pro 
65                  70                  75                  80  


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                85                  90                  95      


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            100                 105                 110         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        115                 120                 125             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    130                 135                 140                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
145                 150                 155                 160 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                165                 170                 175     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            180                 185                 190         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        195                 200                 205             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    210                 215                 220                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
225                 230                 235                 240 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                245                 250                 255     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            260                 265                 270         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        275                 280                 285             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    290                 295                 


<210>  189
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cyno CCR6-Fc

<400>  189

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Met Ser Gly Glu Ser Met Asn Phe Ser Asp Val Phe 
            20                  25                  30          


Asp Ser Ser Glu Asp Tyr Phe Ala Ser Val Asn Thr Ser Tyr Tyr Thr 
        35                  40                  45              


Val Asp Ser Glu Met Leu Leu Cys Thr Leu His Glu Val Arg Gln Phe 
    50                  55                  60                  


Ser Arg Leu Gly Gly Gly Gly Thr Asp Lys Thr His Thr Cys Pro Pro 
65                  70                  75                  80  


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                85                  90                  95      


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            100                 105                 110         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        115                 120                 125             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    130                 135                 140                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
145                 150                 155                 160 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                165                 170                 175     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            180                 185                 190         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        195                 200                 205             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    210                 215                 220                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
225                 230                 235                 240 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                245                 250                 255     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            260                 265                 270         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        275                 280                 285             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    290                 295                 


<210>  190
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Affinity matured CDRH2

<400>  190

Tyr Ile Thr Thr Gly Gly Arg Thr Tyr Tyr Pro Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  191
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 G29A

<400>  191

Gln Ser Ile Val His Ser Asn Ala Asn Thr Tyr Leu Glu 
1               5                   10              


<210>  192
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 G8

<400>  192

Phe Gln Gly Thr Tyr Leu Pro Leu Thr 
1               5                   


<210>  193
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 C9

<400>  193

Phe Gln Gly Thr Tyr Tyr Pro Leu Thr 
1               5                   


<210>  194
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G8 G29A igG1 HC

<400>  194

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Asn Gly Gly Ile Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  195
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G8 G29A IgG1 LC

<400>  195

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Ala Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Thr Tyr Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  196
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C9 G29A IgG1 HC

<400>  196

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Asn Gly Gly Ile Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  197
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C9 G29A IgG1 LC

<400>  197

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Ala Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Thr Tyr Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  198
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3G8 G29A IgG1 HC

<400>  198

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Thr Gly Gly Arg Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Glu 
        435                 440                 445         1   


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
            5                   10                  15          


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr Tyr 
        20                  25                  30              


Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
    35                  40                  45                  


Tyr Ile Thr Thr Gly Gly Arg Thr Tyr Tyr Pro Asp Ser Val Lys Gly 
50                  55                  60                  65  


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
                70                  75                  80      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ser 
            85                  90                  95          


Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
        100                 105                 110             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    115                 120                 125                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
130                 135                 140                 145 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                150                 155                 160     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            165                 170                 175         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        180                 185                 190             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    195                 200                 205                 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
210                 215                 220                 225 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                230                 235                 240     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            245                 250                 255         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        260                 265                 270             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    275                 280                 285                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
290                 295                 300                 305 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                310                 315                 320     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            325                 330                 335         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        340                 345                 350             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    355                 360                 365                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
370                 375                 380                 385 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                390                 395                 400     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            405                 410                 415         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        420                 425                 430             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    435                 440                 445         


<210>  199
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3G8 G29A IgG1 LC

<400>  199

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Ala Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Thr Tyr Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  200
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3C9 G29A IgG1 HC

<400>  200

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Thr Gly Gly Arg Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  201
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3C9 G29A IgG1 LC

<400>  201

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Ala Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Thr Tyr Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  202
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G8 G29A Fab HC

<400>  202

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Asn Gly Gly Ile Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220 


<210>  203
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G8 G29A Fab LC

<400>  203

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Ala Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Thr Tyr Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  204
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C9 G29A Fab HC

<400>  204

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Asn Gly Gly Ile Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220 


<210>  205
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C9 G29A Fab LC

<400>  205

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Ala Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Thr Tyr Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  206
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3G8 G29A Fab HC

<400>  206

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Thr Gly Gly Arg Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220 


<210>  207
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3G8 G29A Fab LC

<400>  207

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Ala Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Thr Tyr Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  208
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3C9 G29A Fab HC

<400>  208

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Thr Gly Gly Arg Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220 


<210>  209
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3C9 G29A Fab LC

<400>  209

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Ala Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Thr Tyr Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  210
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G8 G29A IgG4 S228P HC

<400>  210

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Asn Gly Gly Ile Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 


<210>  211
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G8 G29A IgG4 S228P LC

<400>  211

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Ala Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Thr Tyr Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  212
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C9 G29A IgG4 S228P HC

<400>  212

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Asn Gly Gly Ile Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 


<210>  213
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C9 G29A IgG4 S228P LC

<400>  213

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Ala Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Thr Tyr Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  214
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3G8 G29A IgG4 S228P HC

<400>  214

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Thr Gly Gly Arg Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 


<210>  215
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3G8 G29A IgG4 S228P LC

<400>  215

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Ala Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Thr Tyr Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  216
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3C9 G29A IgG4 S228P HC

<400>  216

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Thr Gly Gly Arg Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 


<210>  217
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3C9 G29A IgG4 S228P LC

<400>  217

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Ala Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Thr Tyr Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  218
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H11 VH5 (N82AS)/VL1 monovalent HC

<400>  218

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Asn Gly Gly Ile Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Lys Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Ala Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Lys Leu Val Cys Leu 
        355                 360                 365             


Val Thr Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Tyr Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Ser Leu Val Ser Trp Leu Asn Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  219
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H11 VH5 (N82AS)/VL1 monovalent LC

<400>  219

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  220
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H11 VH5 (N82AS)/VL1 monovalent Fc

<400>  220

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Glu Val 
        115                 120                 125             


Ala Thr Phe Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Thr 
    130                 135                 140                 


Leu Val Cys Leu Val Thr Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Asp Pro Pro 
                165                 170                 175     


Leu Leu Glu Ser Gln Gly Ser Phe Ala Leu Ser Ser Arg Leu Arg Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  221
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G8 G29A monovalent HC

<400>  221

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Asn Gly Gly Ile Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Lys Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Ala Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Lys Leu Val Cys Leu 
        355                 360                 365             


Val Thr Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Tyr Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Ser Leu Val Ser Trp Leu Asn Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  222
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G8 G29A monovalent LC

<400>  222

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Ala Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Thr Tyr Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  223
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G8 G29A monovalent Fc

<400>  223

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Glu Val 
        115                 120                 125             


Ala Thr Phe Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Thr 
    130                 135                 140                 


Leu Val Cys Leu Val Thr Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Asp Pro Pro 
                165                 170                 175     


Leu Leu Glu Ser Gln Gly Ser Phe Ala Leu Ser Ser Arg Leu Arg Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  224
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C9 G29A monovalent HC

<400>  224

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Asn Gly Gly Ile Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Lys Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Ala Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Lys Leu Val Cys Leu 
        355                 360                 365             


Val Thr Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Tyr Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Ser Leu Val Ser Trp Leu Asn Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  225
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C9 G29A monovalent LC

<400>  225

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Ala Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Thr Tyr Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  226
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C9 G29A monovalent Fc

<400>  226

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Glu Val 
        115                 120                 125             


Ala Thr Phe Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Thr 
    130                 135                 140                 


Leu Val Cys Leu Val Thr Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Asp Pro Pro 
                165                 170                 175     


Leu Leu Glu Ser Gln Gly Ser Phe Ala Leu Ser Ser Arg Leu Arg Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  227
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3G8 G29A monovalent HC

<400>  227

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Thr Gly Gly Arg Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Lys Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Ala Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Lys Leu Val Cys Leu 
        355                 360                 365             


Val Thr Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Tyr Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Ser Leu Val Ser Trp Leu Asn Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  228
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3G8 G29A monovalent LC

<400>  228

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Ala Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Thr Tyr Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  229
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3G8 G29A monovalent Fc

<400>  229

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Glu Val 
        115                 120                 125             


Ala Thr Phe Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Thr 
    130                 135                 140                 


Leu Val Cys Leu Val Thr Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Asp Pro Pro 
                165                 170                 175     


Leu Leu Glu Ser Gln Gly Ser Phe Ala Leu Ser Ser Arg Leu Arg Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  230
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3C9 G29A monovalent HC

<400>  230

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Thr Gly Gly Arg Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Lys Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Ala Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Lys Leu Val Cys Leu 
        355                 360                 365             


Val Thr Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Tyr Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Ser Leu Val Ser Trp Leu Asn Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  231
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3C9 G29A monovalent LC

<400>  231

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Ala Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Thr Tyr Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  232
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B3C9 G29A monovalent Fc

<400>  232

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Glu Val 
        115                 120                 125             


Ala Thr Phe Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Thr 
    130                 135                 140                 


Leu Val Cys Leu Val Thr Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Asp Pro Pro 
                165                 170                 175     


Leu Leu Glu Ser Gln Gly Ser Phe Ala Leu Ser Ser Arg Leu Arg Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  233
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H11 VH5/VL1 Fab HC

<400>  233

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Asn Gly Gly Ile Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220 


<210>  234
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H11 VH5/VL1 Fab LC

<400>  234

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  235
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H11 VH5/VL1 IgG4 S228P HC

<400>  235

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Asn Gly Gly Ile Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 


<210>  236
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4H11 VH5/VL1 IgG4 S228P LC

<400>  236

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  237
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH5/VL1 scFv

<400>  237

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Asn Gly Gly Ile Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Thr Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu 
    130                 135                 140                 


Pro Val Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln 
145                 150                 155                 160 


Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln 
                165                 170                 175     


Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg 
            180                 185                 190         


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr 
    210                 215                 220                 


Tyr Cys Phe Gln Gly Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys Arg 
                245     


<210>  238
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCDR1 VH5 extended

<400>  238

Gly Phe Ser Phe Ser Asp Tyr Tyr Met Tyr Trp 
1               5                   10      


<210>  239
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCDR2 standard

<400>  239

Ile Thr Asn Gly Gly Ile Thr 
1               5           


<210>  240
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCDR2 B3 standard

<400>  240

Ile Thr Thr Gly Gly Arg Thr 
1               5           


<210>  241
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCDR2 VH5 B3 extended

<400>  241

Trp Val Ser Tyr Ile Thr Thr Gly Gly Arg Thr Tyr Tyr Pro Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  242
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCDR2 4H11 B3 extended

<400>  242

Trp Val Ala Tyr Ile Thr Thr Gly Gly Arg Thr Tyr Tyr Pro Asp Thr 
1               5                   10                  15      


Val Lys Gly 
            


<210>  243
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lCDR1 VL1 standard

<400>  243

Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  244
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lCDR1 VL1 extended

<400>  244

Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


Trp Tyr 
        


<210>  245
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lCDR1 G29A standard

<400>  245

Gln Ser Ile Val His Ser Asn Ala Asn Thr Tyr 
1               5                   10      


<210>  246
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lCDR1 G29A extended

<400>  246

Arg Ser Ser Gln Ser Ile Val His Ser Asn Ala Asn Thr Tyr Leu Glu 
1               5                   10                  15      


Trp Tyr 
        


<210>  247
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lCDR2 standard

<400>  247

Lys Val Ser 
1           


<210>  248
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lCDR2 extended

<400>  248

Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
1               5                   10      


<210>  249
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hevay chain variable region IgG4 B3

<400>  249

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Thr Thr Gly Gly Arg Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Pro Leu Arg Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  250
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light VL1 G8

<400>  250

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Thr Tyr Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  251
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light VL1 G29A G8

<400>  251

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Ala Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Thr Tyr Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  252
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light VL1 C9

<400>  252

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Thr Tyr Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  253
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light VL1 G29A C9

<400>  253

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Ala Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Thr Tyr Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  254
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCDR2 4H11 extended

<400>  254

Trp Val Ala Tyr Ile Thr Asn Gly Gly Ile Thr Tyr Tyr Pro Asp Thr 
1               5                   10                  15      


Val Lys Gly 
            


<210>  255
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCDR2 VH5 extended

<400>  255

Trp Val Ser Tyr Ile Thr Asn Gly Gly Ile Thr Tyr Tyr Pro Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  256
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lCDR1 4H11

<400>  256

Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


Trp Tyr 
        


<210>  257
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lCDR2 4H11

<400>  257

Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
1               5                   10      


