                         SEQUENCE LISTING

<110>  Brogdon, Jennifer
       Cipolletta, Daniela
       Dranoff, Glenn
       Knee, Deborah
       Wang, Fei
 
<120>  COMPOSITIONS AND METHODS OF USE FOR AUGMENTED IMMUNE RESPONSE 
       AND CANCER THERAPY

<130>  PAT056489-WO-PCT

<150>  62/061,644
<151>  2014-10-08

<150>  62/220,764
<151>  2015-09-18

<150>  62/198,673
<151>  2015-07-29

<160>  113   

<170>  PatentIn version 3.5

<210>  1
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Gln His Gly Ala Met Gly Ala Phe Arg Ala Leu Cys Gly Leu 
1               5                   10                  15      


Ala Leu Leu Cys Ala Leu Ser Leu Gly Gln Arg Pro Thr Gly Gly Pro 
            20                  25                  30          


Gly Cys Gly Pro Gly Arg Leu Leu Leu Gly Thr Gly Thr Asp Ala Arg 
        35                  40                  45              


Cys Cys Arg Val His Thr Thr Arg Cys Cys Arg Asp Tyr Pro Gly Glu 
    50                  55                  60                  


Glu Cys Cys Ser Glu Trp Asp Cys Met Cys Val Gln Pro Glu Phe His 
65                  70                  75                  80  


Cys Gly Asp Pro Cys Cys Thr Thr Cys Arg His His Pro Cys Pro Pro 
                85                  90                  95      


Gly Gln Gly Val Gln Ser Gln Gly Lys Phe Ser Phe Gly Phe Gln Cys 
            100                 105                 110         


Ile Asp Cys Ala Ser Gly Thr Phe Ser Gly Gly His Glu Gly His Cys 
        115                 120                 125             


Lys Pro Trp Thr Asp Cys Thr Gln Phe Gly Phe Leu Thr Val Phe Pro 
    130                 135                 140                 


Gly Asn Lys Thr His Asn Ala Val Cys Val Pro Gly Ser Pro Pro Ala 
145                 150                 155                 160 


Glu Pro Leu Gly Trp Leu Thr Val Val Leu Leu Ala Val Ala Ala Cys 
                165                 170                 175     


Val Leu Leu Leu Thr Ser Ala Gln Leu Gly Leu His Ile Trp Gln Leu 
            180                 185                 190         


Arg Ser Gln Cys Met Trp Pro Arg Glu Thr Gln Leu Leu Leu Glu Val 
        195                 200                 205             


Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln Phe Pro Glu Glu Glu 
    210                 215                 220                 


Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg Leu Gly Asp Leu Trp 
225                 230                 235                 240 


Val 
    


<210>  2
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Gln His Gly Ala Met Gly Ala Phe Arg Ala Leu Cys Gly Leu 
1               5                   10                  15      


Ala Leu Leu Cys Ala Leu Ser Leu Gly Gln Arg Pro Thr Gly Gly Pro 
            20                  25                  30          


Gly Cys Gly Pro Gly Arg Leu Leu Leu Gly Thr Gly Thr Asp Ala Arg 
        35                  40                  45              


Cys Cys Arg Val His Thr Thr Arg Cys Cys Arg Asp Tyr Pro Gly Glu 
    50                  55                  60                  


Glu Cys Cys Ser Glu Trp Asp Cys Met Cys Val Gln Pro Glu Phe His 
65                  70                  75                  80  


Cys Gly Asp Pro Cys Cys Thr Thr Cys Arg His His Pro Cys Pro Pro 
                85                  90                  95      


Gly Gln Gly Val Gln Ser Gln Gly Lys Phe Ser Phe Gly Phe Gln Cys 
            100                 105                 110         


Ile Asp Cys Ala Ser Gly Thr Phe Ser Gly Gly His Glu Gly His Cys 
        115                 120                 125             


Lys Pro Trp Thr Asp Cys Cys Trp Arg Cys Arg Arg Arg Pro Lys Thr 
    130                 135                 140                 


Pro Glu Ala Ala Ser Ser Pro Arg Lys Ser Gly Ala Ser Asp Arg Gln 
145                 150                 155                 160 


Arg Arg Arg Gly Gly Trp Glu Thr Cys Gly Cys Glu Pro Gly Arg Pro 
                165                 170                 175     


Pro Gly Pro Pro Thr Ala Ala Ser Pro Ser Pro Gly Ala Pro Gln Ala 
            180                 185                 190         


Ala Gly Ala Leu Arg Ser Ala Leu Gly Arg Ala Leu Leu Pro Trp Gln 
        195                 200                 205             


Gln Lys Trp Val Gln Glu Gly Gly Ser Asp Gln Arg Pro Gly Pro Cys 
    210                 215                 220                 


Ser Ser Ala Ala Ala Ala Gly Pro Cys Arg Arg Glu Arg Glu Thr Gln 
225                 230                 235                 240 


Ser Trp Pro Pro Ser Ser Leu Ala Gly Pro Asp Gly Val Gly Ser 
                245                 250                 255 


<210>  3
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Gln His Gly Ala Met Gly Ala Phe Arg Ala Leu Cys Gly Leu 
1               5                   10                  15      


Ala Leu Leu Cys Ala Leu Ser Leu Gly Gln Arg Pro Thr Gly Gly Pro 
            20                  25                  30          


Gly Cys Gly Pro Gly Arg Leu Leu Leu Gly Thr Gly Thr Asp Ala Arg 
        35                  40                  45              


Cys Cys Arg Val His Thr Thr Arg Cys Cys Arg Asp Tyr Pro Gly Glu 
    50                  55                  60                  


Glu Cys Cys Ser Glu Trp Asp Cys Met Cys Val Gln Pro Glu Phe His 
65                  70                  75                  80  


Cys Gly Asp Pro Cys Cys Thr Thr Cys Arg His His Pro Cys Pro Pro 
                85                  90                  95      


Gly Gln Gly Val Gln Ser Gln Gly Lys Phe Ser Phe Gly Phe Gln Cys 
            100                 105                 110         


Ile Asp Cys Ala Ser Gly Thr Phe Ser Gly Gly His Glu Gly His Cys 
        115                 120                 125             


Lys Pro Trp Thr Asp Cys Thr Gln Phe Gly Phe Leu Thr Val Phe Pro 
    130                 135                 140                 


Gly Asn Lys Thr His Asn Ala Val Cys Val Pro Gly Ser Pro Pro Ala 
145                 150                 155                 160 


Glu Pro Leu Gly Trp Leu Thr Val Val Leu Leu Ala Val Ala Ala Cys 
                165                 170                 175     


Val Leu Leu Leu Thr Ser Ala Gln Leu Gly Leu His Ile Trp Gln Leu 
            180                 185                 190         


Arg Lys Thr Gln Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala 
        195                 200                 205             


Arg Ser Cys Gln Phe Pro Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu 
    210                 215                 220                 


Glu Lys Gly Arg Leu Gly Asp Leu Trp Val 
225                 230                 


<210>  4
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  4

Cys Gly Pro Gly Arg Leu Leu Leu Gly Thr Gly Thr Asp Ala Arg Cys 
1               5                   10                  15      


Cys Arg Val His Thr Thr Arg Cys Cys Arg Asp Tyr Pro Gly Glu Glu 
            20                  25                  30          


Cys Cys Ser Glu Trp Asp Cys 
        35                  


<210>  5
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  5

Met Cys Val Gln Pro Glu Phe His Cys Gly Asp Pro Cys Cys Thr Thr 
1               5                   10                  15      


Cys Arg His His Pro Cys Pro Pro Gly Gln Gly Val Gln Ser Gln Gly 
            20                  25                  30          


Lys Phe Ser Phe Gly Phe Gln Cys 
        35                  40  


<210>  6
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  6

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Val Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Trp Gly Gly Gly Gly Thr Tyr Tyr Ala Ser Ser Val Met 
    50                  55                  60                  


Ala Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Ala Tyr Gly His Asp Gly Gly Phe Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  7
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  7

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Ser Ser Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gly Gln Ser Tyr Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  8
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  8

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Val Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Gly Gly Gly Thr Tyr Tyr Thr Ala Ser Leu Met 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Ala Tyr Gly His Asp Gly Gly Phe Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  9
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  9

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gly Gln Ser Tyr Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  10
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Val Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Trp Gly Gly Gly Gly Thr Tyr Tyr Ala Ser Ser Leu Met 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Ala Tyr Gly His Asp Gly Gly Phe Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  11
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  11

His His His His His His 
1               5       


<210>  12
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Val Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Gly Gly Gly Thr Tyr Tyr Thr Ser Ser Leu Met 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Ala Tyr Gly His Asp Gly Gly Phe Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  13

Ala Ala Gly Ala Ser His His His His His His 
1               5                   10      


<210>  14
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Val Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Gly Gly Gly Thr Tyr Tyr Thr Ser Ser Leu Met 
    50                  55                  60                  


Ala Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Ala Tyr Gly His Asp Gly Gly Phe Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  15

Gly Gly Gly Gly Ser 
1               5   


<210>  16
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  (E/Q)

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  (P/S)

<220>
<221>  VARIANT
<222>  (48)..(48)
<223>  (L/V)

<220>
<221>  VARIANT
<222>  (60)..(60)
<223>  (A/T)

<220>
<221>  VARIANT
<222>  (61)..(61)
<223>  (A/S)

<220>
<221>  VARIANT
<222>  (63)..(63)
<223>  (L/V)

<220>
<221>  VARIANT
<222>  (65)..(65)
<223>  (A/G)

<220>
<221>  VARIANT
<222>  (97)..(97)
<223>  (K/R)

<220>
<221>  VARIANT
<222>  (98)..(98)
<223>  (H/N)

<400>  16

Xaa Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Xaa Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Val Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Xaa 
        35                  40                  45              


Gly Val Ile Trp Gly Gly Gly Gly Thr Tyr Tyr Xaa Xaa Ser Xaa Met 
    50                  55                  60                  


Xaa Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Xaa Xaa Ala Tyr Gly His Asp Gly Gly Phe Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  17
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (27)..(27)
<223>  (E/Q)

<220>
<221>  VARIANT
<222>  (33)..(33)
<223>  (L/V)

<220>
<221>  VARIANT
<222>  (39)..(39)
<223>  (K/R)

<220>
<221>  VARIANT
<222>  (60)..(60)
<223>  (D/A)

<400>  17

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Xaa Ser Val Ser Ser Asn 
            20                  25                  30          


Xaa Ala Trp Tyr Gln Gln Xaa Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Xaa Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gly Gln Ser Tyr Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  18
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  18

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  19
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  19
gcgtctagaa ctggatggtg ggaagatgg                                         29


<210>  20
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  20

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  21
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  21

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  22
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  22

Ser Tyr Gly Val Asp 
1               5   


<210>  23
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  23

Val Ile Trp Gly Gly Gly Gly Thr Tyr Tyr Ala Ser Ser Val Met Ala 
1               5                   10                  15      


<210>  24
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  24

Val Ile Trp Gly Gly Gly Gly Thr Tyr Tyr Thr Ala Ser Leu Met Gly 
1               5                   10                  15      


<210>  25
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  25

Val Ile Trp Gly Gly Gly Gly Thr Tyr Tyr Ala Ser Ser Leu Met Gly 
1               5                   10                  15      


<210>  26
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  26

Val Ile Trp Gly Gly Gly Gly Thr Tyr Tyr Thr Ser Ser Leu Met Gly 
1               5                   10                  15      


<210>  27
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  27

Val Ile Trp Gly Gly Gly Gly Thr Tyr Tyr Thr Ser Ser Leu Met Ala 
1               5                   10                  15      


<210>  28
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  (A/T)

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  (A/S)

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  (L/V)

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  (A/G)

<400>  28

Val Ile Trp Gly Gly Gly Gly Thr Tyr Tyr Xaa Xaa Ser Xaa Met Xaa 
1               5                   10                  15      


<210>  29
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  29

His Ala Tyr Gly His Asp Gly Gly Phe Ala Met Asp Tyr 
1               5                   10              


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  30

Arg Ala Ser Glu Ser Val Ser Ser Asn Val Ala 
1               5                   10      


<210>  31
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  31

Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 
1               5                   10      


<210>  32
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  (E/Q)

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  (L/V)

<400>  32

Arg Ala Ser Xaa Ser Val Ser Ser Asn Xaa Ala 
1               5                   10      


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  33

Gly Ala Ser Asn Arg Ala Thr 
1               5           


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  34

Gly Gln Ser Tyr Ser Tyr Pro Phe Thr 
1               5                   


<210>  35
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  35

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser 
            20                  25                  30  


<210>  36
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  36

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser 
            20                  25                  30  


<210>  37
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  (E/Q)

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  (P/S)

<400>  37

Xaa Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Xaa Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser 
            20                  25                  30  


<210>  38
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  38

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
1               5                   10                  


<210>  39
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  39

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly 
1               5                   10                  


<210>  40
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  (L/V)

<400>  40

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Xaa Gly 
1               5                   10                  


<210>  41
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (32)..(32)
<223>  (K/R)

<400>  41

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Xaa 
            20                  25                  30          


<210>  42
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  42

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  43
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  43

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210>  44
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  44

Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  45
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  45

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  46
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  (K/R)

<400>  46

Trp Tyr Gln Gln Xaa Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  47
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  47

Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  48
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  48

Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  49
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  (A/D)

<400>  49

Gly Ile Pro Xaa Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  50
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  50

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  51
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  51
caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccctcagc agctatggtg tggactgggt tcgccaggct      120

ccaggaaagg gtctggagtg ggtgggagtt atatggggtg gtggaggcac atattatgct      180

tcttctgtca tggccagatt caccatctcc agagacaatt ccaagaacac gctgtatctg      240

caaatgaaca gcctgagagc tgaggacacg gccgtgtatt actgcgccaa acatgcctat      300

ggccatgatg gcggctttgc tatggattat tggggccagg gtacccttgt gaccgtgagc      360

tca                                                                    363


<210>  52
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  52
gaaatagtga tgacgcagtc tccagccacc ctgtctgttt ctccaggaga aagagccacc       60

ctctcctgca gggccagtga gagtgttagc agtaatgtag cctggtacca gcagagacct      120

ggccaggcac ccaggctcct catctacggg gcatccaacc gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct      240

gaagattttg cagtgtacta ctgcggccag agctatagct atccatttac ctttggccag      300

ggcaccaagc ttgaaattaa g                                                321


<210>  53
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  53
caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccctcagc agctatggtg tggactgggt tcgccaggct      120

ccaggaaagg gtctggagtg gctgggagtt atatggggtg gtggaggcac atattatact      180

gcttctctca tgggcagatt caccatctcc agagacaatt ccaagaacac gctgtatctg      240

caaatgaaca gcctgagagc tgaggacacg gccgtgtatt actgcgccaa acatgcctat      300

ggccatgatg gcggctttgc tatggattat tggggccagg gtacccttgt gaccgtgagc      360

tca                                                                    363


<210>  54
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  54
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctacggg gcatccaacc gggccactgg catcccagac      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct      240

gaagattttg cagtttacta ctgcggccag agctatagct atccatttac ctttggccag      300

ggcaccaagc ttgaaattaa a                                                321


<210>  55
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  55
gaggtgcagc tggtggagtc cgggggaggc ttagttcagt ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccctcagc agctatggtg tggactgggt tcgccaggct      120

ccaggaaagg gtctggagtg ggtgggagtt atatggggtg gtggaggcac atattatgct      180

tcttctctca tgggcagatt caccatctcc agagacaatt ccaagaacac gctgtatctg      240

caaatgaaca gcctgagagc tgaggacacg gccgtgtatt actgcgccaa acatgcctat      300

ggccatgatg gcggctttgc tatggattat tggggccagg gtacccttgt gaccgtgagc      360

tca                                                                    363


<210>  56
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  56
gaggtgcagc tggtggagtc cgggggaggc ttagttcagt ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccctcagc agctatggtg tggactgggt tcgccaggct      120

ccaggaaagg gtctggagtg gctgggagtt atatggggtg gtggaggcac atattatact      180

tcttctctca tgggcagatt caccatctcc agagacaatt ccaagaacac gctgtatctg      240

caaatgaaca gcctgagagc tgaggacacg gccgtgtatt actgcgccaa acatgcctat      300

ggccatgatg gcggctttgc tatggattat tggggccagg gtacccttgt gaccgtgagc      360

tca                                                                    363


<210>  57
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  57
gaggtgcagc tggtggagtc cgggggaggc ttagttcagt ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccctcagc agctatggtg tggactgggt tcgccaggct      120

ccaggaaagg gtctggagtg gctgggagtt atatggggtg gtggaggcac atattatact      180

tcttctctca tggccagatt caccatctcc agagacaatt ccaagaacac gctgtatctg      240

caaatgaaca gcctgagagc tgaggacacg gccgtgtatt actgcgccaa acatgcctat      300

ggccatgatg gcggctttgc tatggattat tggggccagg gtacccttgt gaccgtgagc      360

tca                                                                    363


<210>  58
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  58
aacattgtaa tgacccaatc tcccaaatcc atgtccatgt cagtaggaga gagggtcacc       60

ttgagctgca aggccagtga gaatgtggat acttttgtat cctggtatca acagaaacca      120

gaccactctc ctaaactact gatatacggg gcatccaacc ggtacactgg ggtccccgat      180

cgcttcacag gcagtggatc tgcaacagat ttcactctga ccatcagcag tgtgcaggct      240

gaagaccttg cagattatca ctgtggacag agttacagct atccattcac gttcggctcg      300

gggacaaagt tggaaataaa a                                                321


<210>  59
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  59

Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Asp Thr Phe 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Asp His Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Ser Tyr Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  60
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  60
caggtgcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc       60

acttgcactg tctctgggtt ttcattaagg agctatggtg tagactgggt tcgccagcct      120

ccaggaaagg gtctggagtg gctgggagtt atatggggtg gtggaggcac aaattataat      180

tcagctctca tggccaaact gagtatcagc aaagacaagt ccaagagcca agttttctta      240

aaaatgaaca gtctgcaaac tgatgacaca gccatgtact actgtgccaa acatgcctat      300

ggtcacgacg gcggttttgc tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tca                                                                    363


<210>  61
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  61

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Arg Ser Tyr 
            20                  25                  30          


Gly Val Asp Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ala Lys Leu Ser Ile Ser Lys Asp Lys Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Ala Tyr Gly His Asp Gly Gly Phe Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  62
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  62

Val Ile Trp Gly Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Met Ala 
1               5                   10                  15      


<210>  63
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  63

Lys Ala Ser Glu Asn Val Asp Thr Phe Val Ser 
1               5                   10      


<210>  64
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  64

Gly Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  65
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  65

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Val Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Trp Gly Gly Gly Gly Thr Tyr Tyr Ala Ser Ser Val Met 
    50                  55                  60                  


Ala Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Ala Tyr Gly His Asp Gly Gly Phe Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  66
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  66

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Ser Ser Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gly Gln Ser Tyr Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  67
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  67
caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccctcagc agctatggtg tggactgggt tcgccaggct      120

ccaggaaagg gtctggagtg ggtgggagtt atatggggtg gtggaggcac atattatgct      180

tcttctgtca tggccagatt caccatctcc agagacaatt ccaagaacac gctgtatctg      240

caaatgaaca gcctgagagc tgaggacacg gccgtgtatt actgcgccaa acatgcctat      300

ggccatgatg gcggctttgc tatggattat tggggccagg gtacccttgt gaccgtgagc      360

tcagctagca ccaagggccc cagcgtgttc cccctggccc ccagcagcaa gagcaccagc      420

ggcggcacag ccgccctggg ctgcctggtg aaggactact tccccgagcc cgtgaccgtg      480

tcctggaaca gcggagccct gacctccggc gtgcacacct tccccgccgt gctgcagagc      540

agcggcctgt acagcctgtc cagcgtggtg acagtgccca gcagcagcct gggcacccag      600

acctacatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gagagtggag      660

cccaagagct gcgacaagac ccacacctgc cccccctgcc cagccccaga gctgctgggc      720

ggaccctccg tgttcctgtt cccccccaag cccaaggaca ccctgatgat cagcaggacc      780

cccgaggtga cctgcgtggt ggtggacgtg agccacgagg acccagaggt gaagttcaac      840

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agcccagaga ggagcagtac      900

aacagcacct acagggtggt gtccgtgctg accgtgctgc accaggactg gctgaacggc      960

aaggaataca agtgcaaggt ctccaacaag gccctgccag cccccatcga aaagaccatc     1020

agcaaggcca agggccagcc acgggagccc caggtgtaca ccctgccccc ctcccgggag     1080

gagatgacca agaaccaggt gtccctgacc tgtctggtga agggcttcta ccccagcgac     1140

atcgccgtgg agtgggagag caacggccag cccgagaaca actacaagac caccccccca     1200

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagtccagg     1260

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1320

acccagaaga gcctgagcct gtcccccggc aag                                  1353


<210>  68
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  68
gaaatagtga tgacgcagtc tccagccacc ctgtctgttt ctccaggaga aagagccacc       60

ctctcctgca gggccagtga gagtgttagc agtaatgtag cctggtacca gcagagacct      120

ggccaggcac ccaggctcct catctacggg gcatccaacc gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct      240

gaagattttg cagtgtacta ctgcggccag agctatagct atccatttac ctttggccag      300

ggcaccaagc ttgaaattaa gcgtacggtg gccgctccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcataag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210>  69
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  69

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Val Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Gly Gly Gly Thr Tyr Tyr Thr Ala Ser Leu Met 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Ala Tyr Gly His Asp Gly Gly Phe Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  70
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  70

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gly Gln Ser Tyr Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  71
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  71
caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccctcagc agctatggtg tggactgggt tcgccaggct      120

ccaggaaagg gtctggagtg gctgggagtt atatggggtg gtggaggcac atattatact      180

gcttctctca tgggcagatt caccatctcc agagacaatt ccaagaacac gctgtatctg      240

caaatgaaca gcctgagagc tgaggacacg gccgtgtatt actgcgccaa acatgcctat      300

ggccatgatg gcggctttgc tatggattat tggggccagg gtacccttgt gaccgtgagc      360

tcagctagca ccaagggccc cagcgtgttc cccctggccc ccagcagcaa gagcaccagc      420

ggcggcacag ccgccctggg ctgcctggtg aaggactact tccccgagcc cgtgaccgtg      480

tcctggaaca gcggagccct gacctccggc gtgcacacct tccccgccgt gctgcagagc      540

agcggcctgt acagcctgtc cagcgtggtg acagtgccca gcagcagcct gggcacccag      600

acctacatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gagagtggag      660

cccaagagct gcgacaagac ccacacctgc cccccctgcc cagccccaga gctgctgggc      720

ggaccctccg tgttcctgtt cccccccaag cccaaggaca ccctgatgat cagcaggacc      780

cccgaggtga cctgcgtggt ggtggacgtg agccacgagg acccagaggt gaagttcaac      840

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agcccagaga ggagcagtac      900

aacagcacct acagggtggt gtccgtgctg accgtgctgc accaggactg gctgaacggc      960

aaggaataca agtgcaaggt ctccaacaag gccctgccag cccccatcga aaagaccatc     1020

agcaaggcca agggccagcc acgggagccc caggtgtaca ccctgccccc ctcccgggag     1080

gagatgacca agaaccaggt gtccctgacc tgtctggtga agggcttcta ccccagcgac     1140

atcgccgtgg agtgggagag caacggccag cccgagaaca actacaagac caccccccca     1200

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagtccagg     1260

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1320

acccagaaga gcctgagcct gtcccccggc aag                                  1353


<210>  72
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  72
gaaatagtga tgacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctacggg gcatccaacc gggccactgg catcccagac      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct      240

gaagattttg cagtttacta ctgcggccag agctatagct atccatttac ctttggccag      300

ggcaccaagc ttgaaattaa acgtacggtg gccgctccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcataag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210>  73
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  73

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Val Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Trp Gly Gly Gly Gly Thr Tyr Tyr Ala Ser Ser Leu Met 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Ala Tyr Gly His Asp Gly Gly Phe Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  74
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  74
gaggtgcagc tggtggagtc cgggggaggc ttagttcagt ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccctcagc agctatggtg tggactgggt tcgccaggct      120

ccaggaaagg gtctggagtg ggtgggagtt atatggggtg gtggaggcac atattatgct      180

tcttctctca tgggcagatt caccatctcc agagacaatt ccaagaacac gctgtatctg      240

caaatgaaca gcctgagagc tgaggacacg gccgtgtatt actgcgccaa acatgcctat      300

ggccatgatg gcggctttgc tatggattat tggggccagg gtacccttgt gaccgtgagc      360

tcagctagca ccaagggccc cagcgtgttc cccctggccc ccagcagcaa gagcaccagc      420

ggcggcacag ccgccctggg ctgcctggtg aaggactact tccccgagcc cgtgaccgtg      480

tcctggaaca gcggagccct gacctccggc gtgcacacct tccccgccgt gctgcagagc      540

agcggcctgt acagcctgtc cagcgtggtg acagtgccca gcagcagcct gggcacccag      600

acctacatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gagagtggag      660

cccaagagct gcgacaagac ccacacctgc cccccctgcc cagccccaga gctgctgggc      720

ggaccctccg tgttcctgtt cccccccaag cccaaggaca ccctgatgat cagcaggacc      780

cccgaggtga cctgcgtggt ggtggacgtg agccacgagg acccagaggt gaagttcaac      840

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agcccagaga ggagcagtac      900

aacagcacct acagggtggt gtccgtgctg accgtgctgc accaggactg gctgaacggc      960

aaggaataca agtgcaaggt ctccaacaag gccctgccag cccccatcga aaagaccatc     1020

agcaaggcca agggccagcc acgggagccc caggtgtaca ccctgccccc ctcccgggag     1080

gagatgacca agaaccaggt gtccctgacc tgtctggtga agggcttcta ccccagcgac     1140

atcgccgtgg agtgggagag caacggccag cccgagaaca actacaagac caccccccca     1200

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagtccagg     1260

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1320

acccagaaga gcctgagcct gtcccccggc aag                                  1353


<210>  75
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  75

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Val Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Gly Gly Gly Thr Tyr Tyr Thr Ser Ser Leu Met 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Ala Tyr Gly His Asp Gly Gly Phe Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  76
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  76
gaggtgcagc tggtggagtc cgggggaggc ttagttcagt ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccctcagc agctatggtg tggactgggt tcgccaggct      120

ccaggaaagg gtctggagtg gctgggagtt atatggggtg gtggaggcac atattatact      180

tcttctctca tgggcagatt caccatctcc agagacaatt ccaagaacac gctgtatctg      240

caaatgaaca gcctgagagc tgaggacacg gccgtgtatt actgcgccaa acatgcctat      300

ggccatgatg gcggctttgc tatggattat tggggccagg gtacccttgt gaccgtgagc      360

tcagctagca ccaagggccc cagcgtgttc cccctggccc ccagcagcaa gagcaccagc      420

ggcggcacag ccgccctggg ctgcctggtg aaggactact tccccgagcc cgtgaccgtg      480

tcctggaaca gcggagccct gacctccggc gtgcacacct tccccgccgt gctgcagagc      540

agcggcctgt acagcctgtc cagcgtggtg acagtgccca gcagcagcct gggcacccag      600

acctacatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gagagtggag      660

cccaagagct gcgacaagac ccacacctgc cccccctgcc cagccccaga gctgctgggc      720

ggaccctccg tgttcctgtt cccccccaag cccaaggaca ccctgatgat cagcaggacc      780

cccgaggtga cctgcgtggt ggtggacgtg agccacgagg acccagaggt gaagttcaac      840

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agcccagaga ggagcagtac      900

aacagcacct acagggtggt gtccgtgctg accgtgctgc accaggactg gctgaacggc      960

aaggaataca agtgcaaggt ctccaacaag gccctgccag cccccatcga aaagaccatc     1020

agcaaggcca agggccagcc acgggagccc caggtgtaca ccctgccccc ctcccgggag     1080

gagatgacca agaaccaggt gtccctgacc tgtctggtga agggcttcta ccccagcgac     1140

atcgccgtgg agtgggagag caacggccag cccgagaaca actacaagac caccccccca     1200

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagtccagg     1260

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1320

acccagaaga gcctgagcct gtcccccggc aag                                  1353


<210>  77
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  77

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Val Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Gly Gly Gly Thr Tyr Tyr Thr Ser Ser Leu Met 
    50                  55                  60                  


Ala Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Ala Tyr Gly His Asp Gly Gly Phe Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  78
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  78
gaggtgcagc tggtggagtc cgggggaggc ttagttcagt ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt ctccctcagc agctatggtg tggactgggt tcgccaggct      120

ccaggaaagg gtctggagtg gctgggagtt atatggggtg gtggaggcac atattatact      180

tcttctctca tggccagatt caccatctcc agagacaatt ccaagaacac gctgtatctg      240

caaatgaaca gcctgagagc tgaggacacg gccgtgtatt actgcgccaa acatgcctat      300

ggccatgatg gcggctttgc tatggattat tggggccagg gtacccttgt gaccgtgagc      360

tcagctagca ccaagggccc cagcgtgttc cccctggccc ccagcagcaa gagcaccagc      420

ggcggcacag ccgccctggg ctgcctggtg aaggactact tccccgagcc cgtgaccgtg      480

tcctggaaca gcggagccct gacctccggc gtgcacacct tccccgccgt gctgcagagc      540

agcggcctgt acagcctgtc cagcgtggtg acagtgccca gcagcagcct gggcacccag      600

acctacatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gagagtggag      660

cccaagagct gcgacaagac ccacacctgc cccccctgcc cagccccaga gctgctgggc      720

ggaccctccg tgttcctgtt cccccccaag cccaaggaca ccctgatgat cagcaggacc      780

cccgaggtga cctgcgtggt ggtggacgtg agccacgagg acccagaggt gaagttcaac      840

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agcccagaga ggagcagtac      900

aacagcacct acagggtggt gtccgtgctg accgtgctgc accaggactg gctgaacggc      960

aaggaataca agtgcaaggt ctccaacaag gccctgccag cccccatcga aaagaccatc     1020

agcaaggcca agggccagcc acgggagccc caggtgtaca ccctgccccc ctcccgggag     1080

gagatgacca agaaccaggt gtccctgacc tgtctggtga agggcttcta ccccagcgac     1140

atcgccgtgg agtgggagag caacggccag cccgagaaca actacaagac caccccccca     1200

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagtccagg     1260

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1320

acccagaaga gcctgagcct gtcccccggc aag                                  1353


<210>  79
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  79

Gly Phe Ser Leu Arg Ser Tyr 
1               5           


<210>  80
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  80

Trp Gly Gly Gly Gly 
1               5   


<210>  81
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  81

Ser Glu Asn Val Asp Thr Phe 
1               5           


<210>  82
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  82

Gly Ala Ser 
1           


<210>  83
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  83

Ser Tyr Ser Tyr Pro Phe 
1               5       


<210>  84
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  84

Gly Phe Ser Leu Ser Ser Tyr 
1               5           


<210>  85
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  85

Ser Glu Ser Val Ser Ser Asn 
1               5           


<210>  86
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  86

Ser Gln Ser Val Ser Ser Asn 
1               5           


<210>  87
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  (E/Q)

<400>  87

Ser Xaa Ser Val Ser Ser Asn 
1               5           


<210>  88
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  88

Arg Pro Thr Gly Gly Pro Gly Cys Gly Pro Gly Arg Leu Leu Gly Thr 
1               5                   10                  15      


Gly Thr Asp Ala Arg Cys Cys Arg Val His Thr Thr Arg Cys Cys Arg 
            20                  25                  30          


Asp Tyr Pro Gly Glu Glu Cys Cys Ser Glu Trp Asp Cys Met Cys Val 
        35                  40                  45              


Gln Pro Glu Phe His Cys Gly Asp 
    50                  55      


<210>  89
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  89

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Arg Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys 
        


<210>  90
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  90

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  91
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  91

Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10                  15  


<210>  92
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  92

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95  


<210>  93
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  93

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  94
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  94

Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10          


<210>  95
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  95
gggtctagac accatggctg tcttggggct gctcttc                                37


<210>  96
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  96
gcgtctagaa yctccacaca caggrrccag tggatagac                              39


<210>  97
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  97
gggtctagac accatggagw cacakwctca ggtctttrta                             40


<210>  98
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  98

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys 
                85              


<210>  99
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  99

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Val Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Trp Gly Gly Gly Gly Thr Tyr Tyr Ala Ser Ser Leu Met 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Ala Tyr Gly His Asp Gly Gly Phe Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  100
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  100

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Val Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Trp Gly Gly Gly Gly Thr Tyr Tyr Ala Ser Ser Leu Met 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Ala Tyr Gly His Asp Gly Gly Phe Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  101
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  101
gaggtgcagc tggtggaatc tggcggcgga ctggtgcagt ccggcggctc tctgagactg       60

tcttgcgctg cctccggctt ctccctgtcc tcttacggcg tggactgggt gcgacaggcc      120

cctggcaagg gcctggaatg ggtgggagtg atctggggcg gaggcggcac ctactacgcc      180

tcttccctga tgggccggtt caccatctcc cgggacaact ccaagaacac cctgtacctg      240

cagatgaact ccctgcgggc cgaggacacc gccgtgtact actgcgccag acacgcctac      300

ggccacgacg gcggcttcgc catggattat tggggccagg gcaccctggt gacagtgtcc      360

tcc                                                                    363


<210>  102
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  102
gagatcgtga tgacccagtc ccccgccacc ctgtctgtgt ctcccggcga gagagccacc       60

ctgagctgca gagcctccga gtccgtgtcc tccaacgtgg cctggtatca gcagagacct      120

ggtcaggccc ctcggctgct gatctacggc gcctctaacc gggccaccgg catccctgcc      180

agattctccg gctccggcag cggcaccgac ttcaccctga ccatctcccg gctggaaccc      240

gaggacttcg ccgtgtacta ctgcggccag tcctactcat accccttcac cttcggccag      300

ggcaccaagc tggaaatcaa g                                                321


<210>  103
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  103
gaggtgcagc tggtggaatc tggcggcgga ctggtgcagt ccggcggctc tctgagactg       60

tcttgcgctg cctccggctt ctccctgtcc tcttacggcg tggactgggt gcgacaggcc      120

cctggcaagg gcctggaatg ggtgggagtg atctggggcg gaggcggcac ctactacgcc      180

tcttccctga tgggccggtt caccatctcc cgggacaact ccaagaacac cctgtacctg      240

cagatgaact ccctgcgggc cgaggacacc gccgtgtact actgcgccag acacgcctac      300

ggccacgacg gcggcttcgc catggattat tggggccagg gcaccctggt gacagtgtcc      360

tccgctagca ccaagggccc aagtgtgttt cccctggccc ccagcagcaa gtctacttcc      420

ggcggaactg ctgccctggg ttgcctggtg aaggactact tccccgagcc cgtgacagtg      480

tcctggaact ctggggctct gacttccggc gtgcacacct tccccgccgt gctgcagagc      540

agcggcctgt acagcctgag cagcgtggtg acagtgccct ccagctctct gggaacccag      600

acctatatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gagagtggag      660

cccaagagct gcgacaagac ccacacctgc cccccctgcc cagctccaga actgctggga      720

gggccttccg tgttcctgtt cccccccaag cccaaggaca ccctgatgat cagcaggacc      780

cccgaggtga cctgcgtggt ggtggacgtg tcccacgagg acccagaggt gaagttcaac      840

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agcccagaga ggagcagtac      900

aacagcacct acagggtggt gtccgtgctg accgtgctgc accaggactg gctgaacggc      960

aaagaataca agtgcaaagt ctccaacaag gccctgccag ccccaatcga aaagacaatc     1020

agcaaggcca agggccagcc acgggagccc caggtgtaca ccctgccccc cagccgggag     1080

gagatgacca agaaccaggt gtccctgacc tgtctggtga agggcttcta ccccagcgat     1140

atcgccgtgg agtgggagag caacggccag cccgagaaca actacaagac caccccccca     1200

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagtccagg     1260

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1320

acccagaagt ccctgagcct gagccccggc aag                                  1353


<210>  104
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  104
gagatcgtga tgacccagtc ccccgccacc ctgtctgtgt ctcccggcga gagagccacc       60

ctgagctgca gagcctccga gtccgtgtcc tccaacgtgg cctggtatca gcagagacct      120

ggtcaggccc ctcggctgct gatctacggc gcctctaacc gggccaccgg catccctgcc      180

agattctccg gctccggcag cggcaccgac ttcaccctga ccatctcccg gctggaaccc      240

gaggacttcg ccgtgtacta ctgcggccag tcctactcat accccttcac cttcggccag      300

ggcaccaagc tggaaatcaa gcgtacggtg gccgctccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

ccccgggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcataag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210>  105
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  105

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Val Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Trp Gly Gly Gly Gly Thr Tyr Tyr Ala Ser Ser Leu Met 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ala Tyr Gly His Asp Gly Gly Phe Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  106
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  106

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Gly Val Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Trp Gly Gly Gly Gly Thr Tyr Tyr Ala Ser Ser Leu Met 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ala Tyr Gly His Asp Gly Gly Phe Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  107
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  107
gaggtgcagc tggtggaatc aggcggcgga ctggtgcagt caggcggtag cctgagactg       60

agctgcgccg cctccggctt tagcctgtct agctacggcg tggactgggt ccgacaggcc      120

cctggcaaag gcctggagtg ggtcggagtg atctggggcg gaggcggaac ctactacgcc      180

tctagcctga tgggccggtt cactatctct agggacaact ctaagaacac cctgtacctg      240

cagatgaact cactgagagc cgaggacacc gccgtctact actgcgctag aaacgcctac      300

ggtcacgacg gcggcttcgc tatggactac tggggtcagg gcaccctggt caccgtgagt      360

tca                                                                    363


<210>  108
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  108
gaggtgcagc tggtggaatc aggcggcgga ctggtgcagt caggcggtag cctgagactg       60

agctgcgccg cctccggctt tagcctgtct agctacggcg tggactgggt ccgacaggcc      120

cctggcaaag gcctggagtg ggtcggagtg atctggggcg gaggcggaac ctactacgcc      180

tctagcctga tgggccggtt cactatctct agggacaact ctaagaacac cctgtacctg      240

cagatgaact cactgagagc cgaggacacc gccgtctact actgcgctag aaacgcctac      300

ggtcacgacg gcggcttcgc tatggactac tggggtcagg gcaccctggt caccgtgagt      360

tcagctagca ctaagggccc aagtgtgttt cccctggccc ccagcagcaa gtctacttcc      420

ggcggaactg ctgccctggg ttgcctggtg aaggactact tccccgagcc cgtgacagtg      480

tcctggaact ctggggctct gacttccggc gtgcacacct tccccgccgt gctgcagagc      540

agcggcctgt acagcctgag cagcgtggtg acagtgccct ccagctctct gggaacccag      600

acctatatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gagagtggag      660

cccaagagct gcgacaagac ccacacctgc cccccctgcc cagctccaga actgctggga      720

gggccttccg tgttcctgtt cccccccaag cccaaggaca ccctgatgat cagcaggacc      780

cccgaggtga cctgcgtggt ggtggacgtg tcccacgagg acccagaggt gaagttcaac      840

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agcccagaga ggagcagtac      900

aacagcacct acagggtggt gtccgtgctg accgtgctgc accaggactg gctgaacggc      960

aaagaataca agtgcaaagt ctccaacaag gccctgccag ccccaatcga aaagacaatc     1020

agcaaggcca agggccagcc acgggagccc caggtgtaca ccctgccccc cagccgggag     1080

gagatgacca agaaccaggt gtccctgacc tgtctggtga agggcttcta ccccagcgat     1140

atcgccgtgg agtgggagag caacggccag cccgagaaca actacaagac caccccccca     1200

gtgctggaca gcgacggcag cttcttcctg tacagcaagc tgaccgtgga caagtccagg     1260

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1320

acccagaagt ccctgagcct gagccccggc aag                                  1353


<210>  109
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  109

Asn Ala Tyr Gly His Asp Gly Gly Phe Ala Met Asp Tyr 
1               5                   10              


<210>  110
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  110
tctggcgcag taatacacgg cc                                                22


<210>  111
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  degenerate trinucleotide codon sequence nnk

<400>  111
nnkgcctatg gccatgatgg cg                                                22


<210>  112
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  112
gcctttctct ccacagg                                                      17


<210>  113
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  113
ggcaaacaac agatggctgg                                                   20


