                         SEQUENCE LISTING

<110>  President and Fellows of Harvard College
       Children's Medical Center Corporation
 
<120>  THERAPEUTIC USES OF GENOME EDITING WITH CRISPR/Cas SYSTEMS

<130>  HRVY-021-WO2

<140>  PCT/US2015/054747
<141>  2015-10-08

<150>  14/509,787
<151>  2014-10-08


<160>  598   

<170>  PatentIn version 3.5

<210>  1
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  1
tgacatcaat tattatacat cgg                                               23


<210>  2
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  2
cctgcctccg ctctactcac tgg                                               23


<210>  3
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  3
tactcactgg tgttcatctt tgg                                               23


<210>  4
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  4
ggtgttcatc tttggttttg tgg                                               23


<210>  5
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  5
gtgttcatct ttggttttgt ggg                                               23


<210>  6
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  6
tggttttgtg ggcaacatgc tgg                                               23


<210>  7
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  7
tcatcctgat aaactgcaaa agg                                               23


<210>  8
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  8
tgacatctac ctgctcaacc tgg                                               23


<210>  9
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  9
tccttcttac tgtccccttc tgg                                               23


<210>  10
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  10
ccttcttact gtccccttct ggg                                               23


<210>  11
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  11
ctcactatgc tgccgcccag tgg                                               23


<210>  12
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  12
tcactatgct gccgcccagt ggg                                               23


<210>  13
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  13
gctgccgccc agtgggactt tgg                                               23


<210>  14
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  14
acaatgtgtc aactcttgac agg                                               23


<210>  15
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  15
caatgtgtca actcttgaca ggg                                               23


<210>  16
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  16
ttgacagggc tctattttat agg                                               23


<210>  17
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  17
tattttatag gcttcttctc tgg                                               23


<210>  18
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  18
tcatcctcct gacaatcgat agg                                               23


<210>  19
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  19
cctgacaatc gataggtacc tgg                                               23


<210>  20
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  20
ctgtgtttgc tttaaaagcc agg                                               23


<210>  21
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  21
gtttgcttta aaagccagga cgg                                               23


<210>  22
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  22
aaagccagga cggtcacctt tgg                                               23


<210>  23
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  23
aagccaggac ggtcaccttt ggg                                               23


<210>  24
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  24
agccaggacg gtcacctttg ggg                                               23


<210>  25
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  25
caggacggtc acctttgggg tgg                                               23


<210>  26
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  26
tggtgacaag tgtgatcact tgg                                               23


<210>  27
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  27
ggtgacaagt gtgatcactt ggg                                               23


<210>  28
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  28
gacaagtgtg atcacttggg tgg                                               23


<210>  29
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  29
aagtgtgatc acttgggtgg tgg                                               23


<210>  30
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  30
gctgtgtttg cgtctctccc agg                                               23


<210>  31
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  31
tttaccagat ctcaaaaaga agg                                               23


<210>  32
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  32
catacagtca gtatcaattc tgg                                               23


<210>  33
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  33
gacattaaag atagtcatct tgg                                               23


<210>  34
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  34
acattaaaga tagtcatctt ggg                                               23


<210>  35
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  35
cattaaagat agtcatcttg ggg                                               23


<210>  36
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  36
aaagatagtc atcttggggc tgg                                               23


<210>  37
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  37
ggtcctgccg ctgcttgtca tgg                                               23


<210>  38
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  38
tgtcatggtc atctgctact cgg                                               23


<210>  39
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  39
gtcatggtca tctgctactc ggg                                               23


<210>  40
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  40
gaatcctaaa aactctgctt cgg                                               23


<210>  41
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  41
ggtgtcgaaa tgagaagaag agg                                               23


<210>  42
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  42
gaaatgagaa gaagaggcac agg                                               23


<210>  43
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  43
aaatgagaag aagaggcaca ggg                                               23


<210>  44
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  44
agaagaggca cagggctgtg agg                                               23


<210>  45
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  45
tgattgttta ttttctcttc tgg                                               23


<210>  46
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  46
gattgtttat tttctcttct ggg                                               23


<210>  47
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  47
ccttctcctg aacaccttcc agg                                               23


<210>  48
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  48
aacaccttcc aggaattctt tgg                                               23


<210>  49
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  49
ataattgcag tagctctaac agg                                               23


<210>  50
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  50
ttgcagtagc tctaacaggt tgg                                               23


<210>  51
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  51
caggttggac caagctatgc agg                                               23


<210>  52
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  52
atgcaggtga cagagactct tgg                                               23


<210>  53
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  53
tgcaggtgac agagactctt ggg                                               23


<210>  54
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  54
cccatcatct atgcctttgt cgg                                               23


<210>  55
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  55
ccatcatcta tgcctttgtc ggg                                               23


<210>  56
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  56
catcatctat gcctttgtcg ggg                                               23


<210>  57
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  57
ctgttctatt ttccagcaag agg                                               23


<210>  58
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  58
tcagtttaca cccgatccac tgg                                               23


<210>  59
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  59
cagtttacac ccgatccact ggg                                               23


<210>  60
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  60
agtttacacc cgatccactg ggg                                               23


<210>  61
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  61
cacccgatcc actggggagc agg                                               23


<210>  62
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  62
tggggagcag gaaatatctg tgg                                               23


<210>  63
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  63
ggggagcagg aaatatctgt ggg                                               23


<210>  64
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  64
taataattga tgtcatagat tgg                                               23


<210>  65
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  65
ttcacattga ttttttggca ggg                                               23


<210>  66
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  66
cttcacattg attttttggc agg                                               23


<210>  67
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  67
tttgcttcac attgattttt tgg                                               23


<210>  68
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  68
gtagagcgga ggcaggaggc ggg                                               23


<210>  69
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  69
agtagagcgg aggcaggagg cgg                                               23


<210>  70
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  70
gtgagtagag cggaggcagg agg                                               23


<210>  71
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  71
ccagtgagta gagcggaggc agg                                               23


<210>  72
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  72
aacaccagtg agtagagcgg agg                                               23


<210>  73
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  73
atgaacacca gtgagtagag cgg                                               23


<210>  74
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  74
ttttgcagtt tatcaggatg agg                                               23


<210>  75
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  75
tcagcctttt gcagtttatc agg                                               23


<210>  76
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR5 gRNA target site sequence

<400>  76
cagagatggc caggttgagc agg                                               23


<210>  77
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  77
aaaacaggtc agagatggcc agg                                               23


<210>  78
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  78
aaggaaaaac aggtcagaga tgg                                               23


<210>  79
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  79
ggacagtaag aaggaaaaac agg                                               23


<210>  80
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  80
cccagaaggg gacagtaaga agg                                               23


<210>  81
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  81
cagcatagtg agcccagaag ggg                                               23


<210>  82
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  82
gcagcatagt gagcccagaa ggg                                               23


<210>  83
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  83
ggcagcatag tgagcccaga agg                                               23


<210>  84
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  84
atttccaaag tcccactggg cgg                                               23


<210>  85
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  85
tgtatttcca aagtcccact ggg                                               23


<210>  86
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  86
ttgtatttcc aaagtcccac tgg                                               23


<210>  87
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  87
ggtacctatc gattgtcagg agg                                               23


<210>  88
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  88
ccaggtacct atcgattgtc agg                                               23


<210>  89
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  89
acacagcatg gacgacagcc agg                                               23


<210>  90
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  90
cttttaaagc aaacacagca tgg                                               23


<210>  91
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  91
caccccaaag gtgaccgtcc tgg                                               23


<210>  92
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  92
cacacttgtc accaccccaa agg                                               23


<210>  93
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  93
atctggtaaa gatgattcct ggg                                               23


<210>  94
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  94
gatctggtaa agatgattcc tgg                                               23


<210>  95
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  95
aagaccttct ttttgagatc tgg                                               23


<210>  96
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  96
gtatggaaaa tgagagctgc agg                                               23


<210>  97
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  97
cagaattgat actgactgta tgg                                               23


<210>  98
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  98
agatgactat ctttaatgtc tgg                                               23


<210>  99
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  99
tgaccatgac aagcagcggc agg                                               23


<210>  100
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  100
cagatgacca tgacaagcag cgg                                               23


<210>  101
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  101
gacaccgaag cagagttttt agg                                               23


<210>  102
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  102
gagaaaataa acaatcatga tgg                                               23


<210>  103
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  103
aggagaagga caatgttgta ggg                                               23


<210>  104
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  104
caggagaagg acaatgttgt agg                                               23


<210>  105
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  105
cctggaaggt gttcaggaga agg                                               23


<210>  106
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  106
agaattcctg gaaggtgttc agg                                               23


<210>  107
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  107
caggccaaag aattcctgga agg                                               23


<210>  108
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  108
tattcaggcc aaagaattcc tgg                                               23


<210>  109
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  109
tagagctact gcaattattc agg                                               23


<210>  110
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  110
tctctgtcac ctgcatagct tgg                                               23


<210>  111
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  111
cgacaaaggc atagatgatg ggg                                               23


<210>  112
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  112
ccgacaaagg catagatgat ggg                                               23


<210>  113
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  113
cccgacaaag gcatagatga tgg                                               23


<210>  114
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  114
tctgaacttc tccccgacaa agg                                               23


<210>  115
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  115
gcttttggaa gaagactaag agg                                               23


<210>  116
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  116
agcgtttggc aatgtgcttt tgg                                               23


<210>  117
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  117
acagcatttg cagaagcgtt tgg                                               23


<210>  118
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  118
ctcgctcggg agcctcttgc tgg                                               23


<210>  119
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  119
taaactgagc ttgctcgctc ggg                                               23


<210>  120
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  120
gtaaactgag cttgctcgct cgg                                               23


<210>  121
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  121
ttcctgctcc ccagtggatc ggg                                               23


<210>  122
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  122
tttcctgctc cccagtggat cgg                                               23


<210>  123
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  123
agatatttcc tgctccccag tgg                                               23


<210>  124
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  124
atcatcttta ccagatctca aaaagaag                                          28


<210>  125
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  125
aactctgctt cggtgtcgaa atgagaag                                          28


<210>  126
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  126
tctgcttcgg tgtcgaaatg agaagaag                                          28


<210>  127
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  127
catcatctat gcctttgtcg gggagaag                                          28


<210>  128
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  128
atgcctttgt cggggagaag ttcagaaa                                          28


<210>  129
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  129
agtgagccca gaaggggaca gtaagaag                                          28


<210>  130
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  130
ctgggcggca gcatagtgag cccagaag                                          28


<210>  131
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  131
gatgatgaag aagattccag agaagaag                                          28


<210>  132
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  132
gaggatgatg aagaagattc cagagaag                                          28


<210>  133
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  133
atcgattgtc aggaggatga tgaagaag                                          28


<210>  134
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  134
caatgttgta gggagcccag aagagaaa                                          28


<210>  135
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  135
aaggacaatg ttgtagggag cccagaag                                          28


<210>  136
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  136
agaattcctg gaaggtgttc aggagaag                                          28


<210>  137
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  137
gcgtttggca atgtgctttt ggaagaag                                          28


<210>  138
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  138
ctggaaaata gaacagcatt tgcagaag                                          28


<210>  139
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  CCR5 gRNA target site sequence

<400>  139
tcgggagcct cttgctggaa aatagaac                                          28


<210>  140
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  140
acttgaagac tcagactcag tgg                                               23


<210>  141
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  141
atgtccacct cgctttcctt tgg                                               23


<210>  142
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  142
cacctcgctt tcctttggag agg                                               23


<210>  143
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  143
ttcctttgga gaggatcttg agg                                               23


<210>  144
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  144
tttggagagg atcttgaggc tgg                                               23


<210>  145
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  145
gctggaccct ctgctcacag agg                                               23


<210>  146
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  146
tcacagaggt gagtgcgtgc tgg                                               23


<210>  147
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  147
cacagaggtg agtgcgtgct ggg                                               23


<210>  148
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  148
ggtgagtgcg tgctgggcag agg                                               23


<210>  149
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  149
ctgggcagag gttttaaatt tgg                                               23


<210>  150
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  150
aggttttaaa tttggctcca agg                                               23


<210>  151
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  151
tggctccaag gaaagcatag agg                                               23


<210>  152
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  152
tccaaggaaa gcatagagga tgg                                               23


<210>  153
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  153
ccaaggaaag catagaggat ggg                                               23


<210>  154
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  154
caaggaaagc atagaggatg ggg                                               23


<210>  155
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  155
ggatggggtt cagacaacag tgg                                               23


<210>  156
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  156
gacaacagtg gaagaaagct agg                                               23


<210>  157
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  157
acaacagtgg aagaaagcta ggg                                               23


<210>  158
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  158
gtggaagaaa gctagggcct cgg                                               23


<210>  159
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  159
gaaagctagg gcctcggtga tgg                                               23


<210>  160
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  160
acccttgctt gatgatttcc agg                                               23


<210>  161
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  161
cttgcttgat gatttccagg agg                                               23


<210>  162
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  162
gatgatttcc aggaggatga agg                                               23


<210>  163
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  163
atgctgatcc caatgtagta agg                                               23


<210>  164
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  164
aatgtagtaa ggcagccaac agg                                               23


<210>  165
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  165
gccaacaggc gaagaaagcc agg                                               23


<210>  166
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  166
aggcgaagaa agccaggatg agg                                               23


<210>  167
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  167
agccaggatg aggatgactg tgg                                               23


<210>  168
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  168
tgaggatgac tgtggtcttg agg                                               23


<210>  169
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  169
gaggatgact gtggtcttga ggg                                               23


<210>  170
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  170
tcttgagggc cttgcgcttc tgg                                               23


<210>  171
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  171
tgagggcctt gcgcttctgg tgg                                               23


<210>  172
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  172
cttgcgcttc tggtggccct tgg                                               23


<210>  173
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  173
gcccttggag tgtgacagct tgg                                               23


<210>  174
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  174
ggagatgata atgcaatagc agg                                               23


<210>  175
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  175
tgataatgca atagcaggac agg                                               23


<210>  176
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  176
caggacagga tgacaatacc agg                                               23


<210>  177
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  177
acaggatgac aataccaggc agg                                               23


<210>  178
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  178
tgacaatacc aggcaggata agg                                               23


<210>  179
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  179
caaccatgat gtgctgaaac tgg                                               23


<210>  180
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  180
cacaaccacc cacaagtcat tgg                                               23


<210>  181
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  181
acaaccaccc acaagtcatt ggg                                               23


<210>  182
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  182
caaccaccca caagtcattg ggg                                               23


<210>  183
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  183
acaagtcatt ggggtagaag cgg                                               23


<210>  184
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  184
gtcatctgcc tcactgacgt tgg                                               23


<210>  185
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  185
gacgttggca aagatgaagt cgg                                               23


<210>  186
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  186
acgttggcaa agatgaagtc ggg                                               23


<210>  187
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  187
tgaagtcggg aatagtcagc agg                                               23


<210>  188
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  188
agtcgggaat agtcagcagg agg                                               23


<210>  189
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  189
gtcgggaata gtcagcagga ggg                                               23


<210>  190
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  190
ggaatagtca gcaggagggc agg                                               23


<210>  191
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  191
gaatagtcag caggagggca ggg                                               23


<210>  192
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  192
ttttcagcca acagcttcct tgg                                               23


<210>  193
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  193
cttccttggc ctctgactgt tgg                                               23


<210>  194
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  194
ccttggcctc tgactgttgg tgg                                               23


<210>  195
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  195
gcctctgact gttggtggcg tgg                                               23


<210>  196
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  196
actgttggtg gcgtggacga tgg                                               23


<210>  197
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  197
tggtggcgtg gacgatggcc agg                                               23


<210>  198
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  198
cgtggacgat ggccaggtag cgg                                               23


<210>  199
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  199
gtagcggtcc agactgatga agg                                               23


<210>  200
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  200
ggtccagact gatgaaggcc agg                                               23


<210>  201
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  201
gactgatgaa ggccaggatg agg                                               23


<210>  202
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  202
ggatgaggac actgctgtag agg                                               23


<210>  203
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  203
ggttgactgt gtagatgaca tgg                                               23


<210>  204
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  204
tgacatggac tgccttgcat agg                                               23


<210>  205
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  205
cccaaagtac cagtttgcca cgg                                               23


<210>  206
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  206
cacggcatca actgcccaga agg                                               23


<210>  207
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  207
acggcatcaa ctgcccagaa ggg                                               23


<210>  208
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  208
agggaagcgt gatgacaaag agg                                               23


<210>  209
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  209
gaagcgtgat gacaaagagg agg                                               23


<210>  210
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  210
cgtgatgaca aagaggaggt cgg                                               23


<210>  211
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  211
agaggaggtc ggccactgac agg                                               23


<210>  212
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  212
tcatgcttct cagtttcttc tgg                                               23


<210>  213
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  213
tcttctggta acccatgacc agg                                               23


<210>  214
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  214
aatgccagtt aagaagatga tgg                                               23


<210>  215
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  215
taagaagatg atggagtaga tgg                                               23


<210>  216
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  216
gaagatgatg gagtagatgg tgg                                               23


<210>  217
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  217
aagatgatgg agtagatggt ggg                                               23


<210>  218
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  218
tgatggagta gatggtgggc agg                                               23


<210>  219
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  219
tgaaattagc attttcttca cgg                                               23


<210>  220
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  220
agcattttct tcacggaaac agg                                               23


<210>  221
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  221
gcattttctt cacggaaaca ggg                                               23


<210>  222
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  222
acggaaacag ggttccttca tgg                                               23


<210>  223
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  223
gtcccctgag cccatttcct cgg                                               23


<210>  224
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  224
gaagtgtata tctgcaaaag agg                                               23


<210>  225
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  225
tatatctgca aaagaggcaa agg                                               23


<210>  226
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  226
ctgcaaaaga ggcaaaggaa tgg                                               23


<210>  227
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  227
ctctccaaag gaaagcgagg tgg                                               23


<210>  228
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  228
atcctctcca aaggaaagcg agg                                               23


<210>  229
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  229
agcctcaaga tcctctccaa agg                                               23


<210>  230
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  230
cactcacctc tgtgagcaga ggg                                               23


<210>  231
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  231
gcactcacct ctgtgagcag agg                                               23


<210>  232
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  232
cccatcctct atgctttcct tgg                                               23


<210>  233
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  233
caagtggatt tccatcaccg agg                                               23


<210>  234
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  234
ttgagaacac tgtgcacaag tgg                                               23


<210>  235
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  235
tcctggaaat catcaagcaa ggg                                               23


<210>  236
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  236
ctcctggaaa tcatcaagca agg                                               23


<210>  237
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  237
catcgactcc ttcatcctcc tgg                                               23


<210>  238
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  238
gttggctgcc ttactacatt ggg                                               23


<210>  239
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  239
tgttggctgc cttactacat tgg                                               23


<210>  240
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  240
tcctggcttt cttcgcctgt tgg                                               23


<210>  241
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  241
gaccacagtc atcctcatcc tgg                                               23


<210>  242
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  242
caagggccac cagaagcgca agg                                               23


<210>  243
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  243
tccaagctgt cacactccaa ggg                                               23


<210>  244
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  244
ctccaagctg tcacactcca agg                                               23


<210>  245
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  245
atggttggcc ttatcctgcc tgg                                               23


<210>  246
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  246
cagtttcagc acatcatggt tgg                                               23


<210>  247
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  247
gttccagttt cagcacatca tgg                                               23


<210>  248
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  248
ctaccccaat gacttgtggg tgg                                               23


<210>  249
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  249
cttctacccc aatgacttgt ggg                                               23


<210>  250
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  250
gcttctaccc caatgacttg tgg                                               23


<210>  251
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  251
catctttgcc aacgtcagtg agg                                               23


<210>  252
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  252
aggtggtcta tgttggcgtc tgg                                               23


<210>  253
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  253
gctgaaaagg tggtctatgt tgg                                               23


<210>  254
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  254
gaagctgttg gctgaaaagg tgg                                               23


<210>  255
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  255
aaggaagctg ttggctgaaa agg                                               23


<210>  256
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  256
tcagaggcca aggaagctgt tgg                                               23


<210>  257
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  257
ccaccaacag tcagaggcca agg                                               23


<210>  258
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  258
tccacgccac caacagtcag agg                                               23


<210>  259
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  259
catcagtctg gaccgctacc tgg                                               23


<210>  260
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  260
catcctggcc ttcatcagtc tgg                                               23


<210>  261
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  261
ctacagcagt gtcctcatcc tgg                                               23


<210>  262
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  262
ctttgggaac ttcctatgca agg                                               23


<210>  263
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  263
ccgtggcaaa ctggtacttt ggg                                               23


<210>  264
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  264
gccgtggcaa actggtactt tgg                                               23


<210>  265
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  265
cagttgatgc cgtggcaaac tgg                                               23


<210>  266
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  266
cttctgggca gttgatgccg tgg                                               23


<210>  267
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  267
tgtcatcacg cttcccttct ggg                                               23


<210>  268
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  268
ttgtcatcac gcttcccttc tgg                                               23


<210>  269
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  269
gtacaggctg cacctgtcag tgg                                               23


<210>  270
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  270
gaagcatgac ggacaagtac agg                                               23


<210>  271
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  271
gaagaaactg agaagcatga cgg                                               23


<210>  272
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  272
ggattggtca tcctggtcat ggg                                               23


<210>  273
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  273
tggattggtc atcctggtca tgg                                               23


<210>  274
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  274
gggcaatgga ttggtcatcc tgg                                               23


<210>  275
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  275
tggcattgtg ggcaatggat tgg                                               23


<210>  276
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  276
ttaactggca ttgtgggcaa tgg                                               23


<210>  277
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  277
atcttcttaa ctggcattgt ggg                                               23


<210>  278
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  278
catcttctta actggcattg tgg                                               23


<210>  279
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  279
tactccatca tcttcttaac tgg                                               23


<210>  280
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  280
aggggactat gactccatga agg                                               23


<210>  281
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  281
caccgaggaa atgggctcag ggg                                               23


<210>  282
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  282
acaccgagga aatgggctca ggg                                               23


<210>  283
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  283
tacaccgagg aaatgggctc agg                                               23


<210>  284
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  284
gataactaca ccgaggaaat ggg                                               23


<210>  285
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  285
agataactac accgaggaaa tgg                                               23


<210>  286
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  286
cacttcagat aactacaccg agg                                               23


<210>  287
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  287
gatggggttc agacaacagt ggaagaaa                                          28


<210>  288
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  288
gtagtaaggc agccaacagg cgaagaaa                                          28


<210>  289
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  289
aaccacccac aagtcattgg ggtagaag                                          28


<210>  290
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  290
gtttgccacg gcatcaactg cccagaag                                          28


<210>  291
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  291
tccattgccc acaatgccag ttaagaag                                          28


<210>  292
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  292
catcaagcaa gggtgtgagt ttgagaac                                          28


<210>  293
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  293
gctgtcacac tccaagggcc accagaag                                          28


<210>  294
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  294
tcatgggtta ccagaagaaa ctgagaag                                          28


<210>  295
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  295
catcctggtc atgggttacc agaagaaa                                          28


<210>  296
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  296
ggtcatcctg gtcatgggtt accagaag                                          28


<210>  297
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  CXCR4 gRNA target site sequence

<400>  297
atgaaggaac cctgtttccg tgaagaaa                                          28


<210>  298
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  298
gtcttgctcg agatgtgatg                                                   20


<210>  299
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  gRNA

<400>  299
taaattcttt gctgacctgc                                                   20


<210>  300
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  gRNA

<400>  300
tagatccatt cctatgactg                                                   20


<210>  301
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  gRNA

<400>  301
cttcagtctg ataaaatcta                                                   20


<210>  302
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  gRNA

<400>  302
tttgatgtaa tccagcaggt                                                   20


<210>  303
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  gRNA

<400>  303
cacagagggc tacaatgtga                                                   20


<210>  304
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  304
gtagagcgga ggcaggaggc ggg                                               23


<210>  305
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  305
gtgagtagag cggaggcagg agg                                               23


<210>  306
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  306
ggtgttcatc tttggttttg tgg                                               23


<210>  307
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  307
gtgttcatct ttggttttgt ggg                                               23


<210>  308
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  308
ggacagtaag aaggaaaaac agg                                               23


<210>  309
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  309
gctgccgccc agtgggactt tgg                                               23


<210>  310
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  310
gcagcatagt gagcccagaa ggg                                               23


<210>  311
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  311
ggcagcatag tgagcccaga agg                                               23


<210>  312
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  312
ggtacctatc gattgtcagg agg                                               23


<210>  313
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  313
gtttgcttta aaagccagga cgg                                               23


<210>  314
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  314
ggtgacaagt gtgatcactt ggg                                               23


<210>  315
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  315
gacaagtgtg atcacttggg tgg                                               23


<210>  316
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  316
gctgtgtttg cgtctctccc agg                                               23


<210>  317
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  317
gatctggtaa agatgattcc tgg                                               23


<210>  318
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  318
gtatggaaaa tgagagctgc agg                                               23


<210>  319
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  319
gacattaaag atagtcatct tgg                                               23


<210>  320
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  320
ggtcctgccg ctgcttgtca tgg                                               23


<210>  321
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  321
gtcatggtca tctgctactc ggg                                               23


<210>  322
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  322
gaatcctaaa aactctgctt cgg                                               23


<210>  323
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  323
ggtgtcgaaa tgagaagaag agg                                               23


<210>  324
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  324
gacaccgaag cagagttttt agg                                               23


<210>  325
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  325
gaaatgagaa gaagaggcac agg                                               23


<210>  326
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  326
gattgtttat tttctcttct ggg                                               23


<210>  327
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  327
gagaaaataa acaatcatga tgg                                               23


<210>  328
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  328
gcttttggaa gaagactaag agg                                               23


<210>  329
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  329
gtaaactgag cttgctcgct cgg                                               23


<210>  330
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  330
ggggagcagg aaatatctgt ggg                                               23


<210>  331
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  331
acaatgtgtc aactcttgac agg                                               23


<210>  332
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  332
tcactatgct gccgcccagt ggg                                               23


<210>  333
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Target site sequence with NGG

<400>  333
ggtacctatc gattgtcagg agg                                               23



<210>  334
<211>  1368
<212>  PRT
<213>  Unknown

<220>
<223>  CAS protein

<400>  334

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             



<210>  335
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  335
tcccttcctg cctcatttca ggtgaataca tcaagacctg gaggcca                     47


<210>  336
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  336
tcccttcctg cctcatttca ggtgaataca tcaagacctg gaggcca                     47


<210>  337
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  337
tgctggctcg gctgccctga ggttgctcaa tcaagcacag gtttcaa                     47


<210>  338
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  338
tgctggctcg gctgccctga ggttgctcaa tcaagcacag gtttcaa                     47


<210>  339
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  339
taacagcgat gctgaccccc tgtgcctcta ccacttctat gaccaga                     47


<210>  340
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  340
cgatgctgac cccctgtgcc tctaccactt ctatgaccag atggacc                     47


<210>  341
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  341
tggtccttgc tgtgttctct gcggtgcttg gctccctgca gtttgggta                   49


<210>  342
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  342
tggtccttgc tgtgttctct gcggtgcttg gctccctgca gtttgggta                   49


<210>  343
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  343
tgggcgacag atgcgaaaga aacgagttcc agtgccaaga cgggaaa                     47


<210>  344
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  344
gaaacgagtt ccagtgccaa gacgggaaat gcatctccta caagtgg                     47


<210>  345
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  345
tcagagagga cactgcagtt gtccgtgcta gtagccttcg cttctgga                    48


<210>  346
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  346
tcagagagga cactgcagtt gtccgtgcta gtagccttcg cttctgga                    48


<210>  347
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  347
tgatgatctc agaggctcag tatccttgtc ctgggttgga gatagca                     47


<210>  348
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  348
tgatgatctc agaggctcag tatccttgtc ctgggttgga gatagca                     47


<210>  349
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  349
tggtaattat gacttttgga cagtccaagc tatatcgaag gtgagatca                   49


<210>  350
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  350
tggtaattat gacttttgga cagtccaagc tatatcgaag gtgagatca                   49


<210>  351
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  351
tcccttcctg cctcatttca ggtgaataca tcaagacctg gaggcca                     47


<210>  352
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  352
tcccttcctg cctcatttca ggtgaataca tcaagacctg gaggcca                     47


<210>  353
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  353
ctatgccctg cctcatttca ggtgaagatg aaatccctgg agcttgg                     47


<210>  354
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  354
ctccctgggc tgcaccatag tga                                               23


<210>  355
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  355
gaccttgtga agatgattcc tgg                                               23


<210>  356
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  356
gatctgggga agaggattcc agg                                               23


<210>  357
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  357
agattgtgta tactcttgac tag                                               23


<210>  358
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  358
ccaggaatca tctctacgat atc                                               23


<210>  359
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  359
cctggaattc tctttactag atc                                               23


<210>  360
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  360
ccggggagag gcgcggacac agc                                               23


<210>  361
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  361
ccagggagag acggaaccaa aac                                               23


<210>  362
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  362
gatctgatac agatgattca tgg                                               23


<210>  363
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  363
ctgggaatca tctttacaag atg                                               23


<210>  364
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  364
tgaatatcct gtcgcccagt cag                                               23


<210>  365
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  365
ccacccaagt gatcactctt cct                                               23


<210>  366
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  366
aggaagagtg atcacttggg tgg                                               23


<210>  367
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  367
tctgtgtttt tgtctctccc cag                                               23


<210>  368
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  368
aggaagagtg atcacttggg tgg                                               23


<210>  369
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  369
ccacccaagt gatcactctt cct                                               23


<210>  370
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  370
ctaggaatca tcttccccag atg                                               23


<210>  371
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  371
tctgtggaaa agatgattcc aag                                               23


<210>  372
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  372
gttcttgtta agatgattcc tgg                                               23


<210>  373
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  373
ggcatgtttc atcacttggg ggg                                               23


<210>  374
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  374
gggctggtaa agatgtttcc agg                                               23


<210>  375
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  375
gacaagtgtg atcacctggt tgg                                               23


<210>  376
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  376
gctgtgtttg cttctgtccc agg                                               23


<210>  377
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  377
ccaggaatca tctttactaa atg                                               23


<210>  378
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  378
tcactatgct gccgcccagt ggg                                               23


<210>  379
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  379
gctgccgccc agtgggactt tgg                                               23


<210>  380
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  380
acaatgtgtc aactcttgac agg                                               23


<210>  381
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  381
gacaagtgtg atcacttggg tgg                                               23


<210>  382
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  382
gctgtgtttg cgtctctccc agg                                               23


<210>  383
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  383
ccaggaatca tctttaccag atc                                               23


<210>  384
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  384
acaaggggtc aactctggac aag                                               23


<210>  385
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  385
cccactgggc tgcagcatcc tgg                                               23


<210>  386
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  386
ccagcgcgtg acgcaaacac agc                                               23


<210>  387
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  387
acaatgtgtc accttttaac tgg                                               23


<210>  388
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  388
acaatatttc aacacttgac aag                                               23


<210>  389
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  389
cttggagtca tctttgccac atc                                               23


<210>  390
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  390
gacaagcgtg atcccatggg gag                                               23


<210>  391
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  391
cctcccaagt aatcaccctt ttc                                               23


<210>  392
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  392
cccaagtccc actggcaggt ggc                                               23


<210>  393
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  393
gctatgtgtt aactcttgac aag                                               23


<210>  394
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  394
ccactatggt gcctcccagt cag                                               23


<210>  395
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  395
tcactctgct gctgtccagt ggg                                               23


<210>  396
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  396
actctgtcct gccgcccagt gag                                               23


<210>  397
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  397
cttggaatca tctctacctg att                                               23


<210>  398
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  398
cccaagtccc actgggtgac atg                                               23


<210>  399
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  399
ctaaggagag aggcacacac agc                                               23


<210>  400
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  400
ccagggaggg acgcaaaccc agc                                               23


<210>  401
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  401
cttctcaagt gatcccactg gtc                                               23


<210>  402
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  402
cctgagagag aagcaaacac aga                                               23


<210>  403
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  403
cttaggaaag acgcaaacat agc                                               23


<210>  404
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  404
acattgatta aactcttgac tag                                               23


<210>  405
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  405
acaaagttta aactcttgag cag                                               23


<210>  406
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  406
cttcccaagt gattacactt tat                                               23


<210>  407
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  407
cccactgggg cgcagcctag tga                                               23


<210>  408
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  408
cttgtcaaga tttgccacat tat                                               23


<210>  409
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  409
ccttggtgag aggcaaacac agc                                               23


<210>  410
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  410
cctactgggc gtcagcactg tgt                                               23


<210>  411
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  411
tcactatgca gcaccccagt ggg                                               23


<210>  412
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  412
ccaggcatct tctttaccag ctc                                               23


<210>  413
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  413
ctcactgggc tgcagcattg ggg                                               23


<210>  414
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  414
ccagggagag acgcagaaac aac                                               23


<210>  415
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  415
tacatgagta atcacttggg gag                                               23


<210>  416
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  416
ctccccaagt gattactcat gta                                               23


<210>  417
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  417
cagaggtgtg atcacttggg cag                                               23


<210>  418
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  418
cttcccatgt gataacactt gtc                                               23


<210>  419
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  419
cctgagagag aggcaaacac atc                                               23


<210>  420
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  420
ccacgaatcc tctttaccaa atc                                               23


<210>  421
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  421
cctgagggtg cgtctctccc ggg                                               23


<210>  422
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  422
gctgtgtgct cgtctctccc tgg                                               23


<210>  423
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  423
gctgcggccc agcgggacct ggg                                               23


<210>  424
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  424
gctgtacttg ggtctctccc cag                                               23


<210>  425
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  425
gccgtgtttt cctctctccc aag                                               23


<210>  426
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  426
cccactgggc tgcagaatac aga                                               23


<210>  427
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  427
ccccccagga gatcacattt gtc                                               23


<210>  428
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  428
gctgccggac agtgggacct ggg                                               23


<210>  429
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  429
ctgactggac ggcaccttag tga                                               23


<210>  430
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  430
gctgtctttt cctctctccc tgg                                               23


<210>  431
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  431
ccagaaataa tctttaccag ctc                                               23


<210>  432
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  432
gctgtgtttg tgcctccccc agg                                               23


<210>  433
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  433
acaatgtgtt ggctcttgac tag                                               23


<210>  434
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  434
gacaagtctg atcattttgg ggg                                               23


<210>  435
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  435
ccacggagaa acacaaacac agc                                               23


<210>  436
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  436
aaaatgtgtc aactcttgat tag                                               23


<210>  437
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  437
tctgtgtttg cctctctctc agg                                               23


<210>  438
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  438
acaatgtgcc agctctggac tag                                               23


<210>  439
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  439
gacaagtatg agcacttggt aag                                               23


<210>  440
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  440
gactagtgtg ttctcttggg aag                                               23


<210>  441
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  441
gacatgtgta aacacttggg aag                                               23


<210>  442
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  442
ccaaagtccc actgggtgac atc                                               23


<210>  443
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  443
cctgtgagag gctcaaacac agc                                               23


<210>  444
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  444
ccgcagtccc actgtgcggc acc                                               23


<210>  445
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  445
gacaagtgtg ttcacttctg cag                                               23


<210>  446
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  446
gatttgggaa agatcattcc agg                                               23


<210>  447
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  447
gctttggtaa agttgattcc tag                                               23


<210>  448
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  448
aaactgtgat aactcttgac tgg                                               23


<210>  449
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  449
cctaagtccc actggccgaa agt                                               23


<210>  450
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  450
gttctggtca agatgactcc tgg                                               23


<210>  451
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  451
cccaggaccc actgggcagc agc                                               23


<210>  452
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  452
aaaatctgtc aactcttgaa tag                                               23


<210>  453
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  453
ctcatcagga gtggacacat tgt                                               23


<210>  454
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  454
ccagggggac acgcaaacac tgc                                               23


<210>  455
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  455
tcactttgct gccagccagt tgg                                               23


<210>  456
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  456
ctgaagtccc actgggtggg tgt                                               23


<210>  457
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  457
gcaccagccc agtgggactt cag                                               23


<210>  458
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  458
ccagggaaag aggcaagcac agc                                               23


<210>  459
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  459
ccactataca cccgcccagt cag                                               23


<210>  460
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  460
ccattgtgct gccgcccagc cag                                               23


<210>  461
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  461
gatctggaag agatgattcc aag                                               23


<210>  462
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  462
cccgggaggg aggcaaaaac agc                                               23


<210>  463
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  463
gctgagtctg ggtctctccc cag                                               23


<210>  464
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  464
cctggaatgt tctttcccag atc                                               23


<210>  465
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  465
gacaggtgtg agcactttgg gag                                               23


<210>  466
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  466
gacacttgtg atgacttggg tag                                               23


<210>  467
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  467
ctttggagag acgcagacac tgc                                               23


<210>  468
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  468
ctacccaagt gttcatattt gtc                                               23


<210>  469
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  469
ccagaaatca tgtttaccag ctc                                               23


<210>  470
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  470
ctggagtccc actgcgcggc agc                                               23


<210>  471
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  471
cctgggaaag gcgcaaacac agc                                               23


<210>  472
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  472
gatctgataa aggtgagtcc agg                                               23


<210>  473
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  473
gcaagttgct gccgcccagt ggg                                               23


<210>  474
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  474
gcagtgtgtg ggtctctccc agg                                               23


<210>  475
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  475
ccaaagtcgc actggcctgc agc                                               23


<210>  476
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  476
gatctgggag agaagattcc agg                                               23


<210>  477
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  477
ccagaaaaga gttgacacat agt                                               23


<210>  478
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  478
cctgccaagg gttgacacat ggt                                               23


<210>  479
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  479
gacaagtgtc ataactttgg aag                                               23


<210>  480
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  480
ataatgtgtc aaccctggac cag                                               23


<210>  481
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  481
ccaaagaccc actggacggc agc                                               23


<210>  482
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  482
ccaactggcc ggcagcctgg tga                                               23


<210>  483

<400>  483
000

<210>  484
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  484
tatgctgccg cccagtggga ctttggaaat acaatgtgtc aactc                       45


<210>  485
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  485
ggctgtgttt gcgtctctcc caggaatcat ctttaccaga tctca                       45


<210>  486
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  486
tatgctgccg cccagtggga                                                   20


<210>  487
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  487
atcatcttta ccagatctca aaaag                                             25


<210>  488
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  488
gagttgacac attgtatttc caaag                                             25


<210>  489
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  489
atcatcttta ccagatctca                                                   20


<210>  490
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  490
tcctgggaga gacgcaaaca cagcc                                             25


<210>  491
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  491
tggctgtgtt tgcgtctctc ccagg                                             25


<210>  492
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  492
catcatcttt accagatctc aaaaa                                             25


<210>  493
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  493
tttggaaata caatgtgtca actct                                             25


<210>  494
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  494
tcatctttac cagatctcaa aaaga                                             25


<210>  495
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  495
gctgtgtttg cgtctctccc aggaa                                             25


<210>  496
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  496
actttggaaa tacaatgtgt caact                                             25


<210>  497
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  497
tggaaataca atgtgtcaac tcttg                                             25


<210>  498
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  498
gtggctgtgt ttgcgtctct cccag                                             25


<210>  499
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  499
tcctttggaa atacaatgtg tcaac                                             25


<210>  500
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  500
atctttacca gatctcaaaa agaag                                             25


<210>  501
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  501
tggtggctgt gtttgcgtct ctccc                                             25


<210>  502
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  502
aatcatcttt accagatctc aaaaa                                             25


<210>  503
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  503
tcactatgct gccgcccagt gggaa                                             25


<210>  504
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  504
aatgtgtcaa ctcttgacag ggctc                                             25


<210>  505
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  505
ttggaaatac aatgtgtcaa ctctt                                             25


<210>  506
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  506
gagttacatg atcccccatg ttgtg                                             25


<210>  507
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  507
gtggtggctg tgtttgcgtc tcccc                                             25


<210>  508
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  508
ggctgtgttt gcgtctctcc caggtatcat ctttaccaga tctca                       45


<210>  509
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  509
catctttacc agatctcaaa aagaa                                             25


<210>  510
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  510
aatacaatgt gtcaactctt gacag                                             25


<210>  511
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  511
atacaatgtg tcaactcttg acagg                                             25


<210>  512
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  512
tatgctgccg cccagtggga ttttggaaat acaatgtttc aactc                       45


<210>  513
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  513
atacaatgtg tcaactcttg acagggctct attttatagg cttct                       45


<210>  514
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  514
ggctcactat gctgccgccc agtgggactt tggaaataca atgtg                       45


<210>  515
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  515
ggctcactat gctgccgccc                                                   20


<210>  516
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  516
gacagggctc tattttatag gcttc                                             25


<210>  517
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  517
tgacagggct ctattttata ggctt                                             25


<210>  518
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  518
ttgacagggc tctattttat aggct                                             25


<210>  519
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  519
aatacaatgt gtcaactct                                                    19


<210>  520
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  520
gacagggctc tattttatag gcttct                                            26


<210>  521
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  521
ggctcactat gctgccgccc agggggactt tggaaataca atgtg                       45


<210>  522
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  522
gggactttgg aaatacaatg tgtca                                             25


<210>  523
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  523
ccggcaaaca aaccaccgc                                                    19


<210>  524
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  524
gaaatacaat gtgtcaact                                                    19


<210>  525
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  525
tcactataca atgtgtcaag ac                                                22


<210>  526
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  526
agggctctat tttataggct tct                                               23


<210>  527
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  527
aaatacaatg tgtcaactc                                                    19


<210>  528
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  528
aacagggctc tattttatag gcttc                                             25


<210>  529
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  529
atacaatgtg tcaactcttg acaaggctct attttatagg cttct                       45


<210>  530
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  530
cccagtggga ctttggaaaa                                                   20


<210>  531
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  531
acagggctct attttatagg cttct                                             25


<210>  532
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  532
atacaatgtg tcaactcct                                                    19


<210>  533
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  533
atacaatgtg tcaactctc                                                    19


<210>  534
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  534
ggctcactat gctgccgccc agtgggactt tggaaataca atgtg                       45


<210>  535
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  535
gggtggtggc tgtgtttgcg tctctcccag gaatcatctt tacca                       45


<210>  536
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  536
ttctgggctc actatgctgc cgccc                                             25


<210>  537
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  537
cccaggaatc atctttacca                                                   20


<210>  538
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  538
ggctcactat gctgccgccc                                                   20


<210>  539
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  539
cccaggaatc atctttacca gatct                                             25


<210>  540
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  540
tcccaggaat catctttacc agatc                                             25


<210>  541
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  541
tctgggctca ctatgctgcc gccct                                             25


<210>  542
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  542
agagacgcaa acacagccac caccc                                             25


<210>  543
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  543
cacattgtat ttccaaagtc ccact                                             25


<210>  544
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  544
aatgtgtcaa ctcttgacag ggctc                                             25


<210>  545
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  545
acattgtatt tccaaagtcc cactt                                             25


<210>  546
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  546
tagtgggact ttggaaatac aatgt                                             25


<210>  547
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  547
ggtggtggct gtgtttgcgt ctctt                                             25


<210>  548
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  548
cttctgggct cactatgctg ccgcc                                             25


<210>  549
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  549
gctgtttcct gtgtgaaatt gttat                                             25


<210>  550
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  550
cccttctggg ctcactatgc tgccg                                             25


<210>  551
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  551
aggaatcatc tttaccagat ctcaa                                             25


<210>  552
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  552
ccaggaatca tctttaccag atctc                                             25


<210>  553
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  553
ttactgtcgt ccatgctgtg tttgc                                             25


<210>  554
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  554
tcccaggaat catctttacc a                                                 21


<210>  555
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  555
ttaccagatc tcaaaaagaa ggtct                                             25


<210>  556
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  556
tgtataccgt cgacctctag ctaga                                             25


<210>  557
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  557
cagtgggact ttggaaatac aatgt                                             25


<210>  558
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  558
tgggactttg gaaatacaat gtgtc                                             25


<210>  559
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  559
aatacaatgt gtcaactctt gacag                                             25


<210>  560
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  560
tctcccagga atcatcttta ccaga                                             25


<210>  561
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  561
tgggctcact atgctgccgc cctct                                             25


<210>  562
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  562
tactgtcccc ttctgggctc actat                                             25


<210>  563
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  563
tgggtggtgg ctgtgtttgc gtctt                                             25


<210>  564
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  564
acttgggtgg tggctgtgtt tgcgt                                             25


<210>  565
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  565
aagtgggact ttggaaatac aatgt                                             25


<210>  566
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  566
gtgggacttt ggaaatacaa tgtgt                                             25


<210>  567
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  567
tcttcatcat cctcctgaca atcga                                             25


<210>  568
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  568
ttataggctt cttctctgga atctt                                             25


<210>  569
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  569
ttcttcgatc agtctaaaaa tggct                                             25


<210>  570
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  570
catctttacc agatctcaaa aagaa                                             25


<210>  571
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  571
aataggcttc ttctctggaa tcttc                                             25


<210>  572
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  572
tttggggtgg tgacaagtgt gatca                                             25


<210>  573
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  573
ttaaaagcca ggacggtcac ctttg                                             25


<210>  574
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  574
tgtttgcgtc tctcccagga atcat                                             25


<210>  575
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  575
agtgtgatca cttgggtggt ggctg                                             25


<210>  576
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  576
tctggaatct tcttcatcat cctcc                                             25


<210>  577
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  577
ggctcactat gctgccgccc tgtgggactt tggaaataca atgtg                       45


<210>  578
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  578
tttggaaata caatgtgtca actct                                             25


<210>  579
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  579
cccaagaatc atctttacca gatct                                             25


<210>  580
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  580
ccttctgggc tcactatgct gccgc                                             25


<210>  581
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  581
tgggtggtgg ctgtgtttgc gtctc                                             25


<210>  582
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  582
acaatgtgtc aactcttgac agggc                                             25


<210>  583
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  583
gtgggacttt ggaaattcaa tgtgt                                             25


<210>  584
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  584
gcccaggaat catctttacc agatc                                             25


<210>  585
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  585
ggctgtgttt gcgtctctcc aggaa                                             25


<210>  586
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  586
tcttactgtc cccttctgcg tctct                                             25


<210>  587
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  587
ggtggtggct gtgtttgcgt ctctc                                             25


<210>  588
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  588
ccaggaatca tctttactaa atg                                               23


<210>  589
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  589
ccaggcatct tctttaccag ctc                                               23


<210>  590
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  590
aaaatgtgtc aactcttgat tag                                               23


<210>  591
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  591
cccactgggc tgcagaatac aga                                               23


<210>  592
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  592
tctgtgtttg cctctctctc agg                                               23


<210>  593
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  593
cccgggaggg aggcaaaaac agc                                               23


<210>  594
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  594
actgtctccc tgtagaaaac tgg                                               23


<210>  595
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  595
catttagtaa agatgattcc tgg                                               23


<210>  596
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  596
gcattttctg ttctctgaag t                                                 21


<210>  597
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  597
tcactaggca tgctgccaga gc                                                22


<210>  598
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  target sequence

<400>  598
gctgtgtttg cttctgtccc agg                                               23


